Reference on EC 1.6.2.4 - NADPH-hemoprotein reductase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Honeck, H.; Schunck, W.H.; Riege, P.; Muller, H.G.
The cytochrome P-450 alkane monooxygenase system of the yeast Lodderomyces elongisporus: purification and some properties of the NADPH-cytochrome P-450 reductase
Biochem. Biophys. Res. Commun.
106
1318-1324
1982
Lodderomyces elongisporus
Feyereisen, R.; Durst, F.
Ecdysterone biosynthesis: a microsomal cytochrome-P-450-linked ecdysone 20-monooxygenase from tissues of the African migratory locust
Eur. J. Biochem.
88
37-47
1978
Locusta migratoria migratorioides
Kojima, H.; Takahashi, K.; Sakane, F.; Koyama, J.
Purification and characterization of NADPH-cytochrome c reductase from porcine polymorphonuclear leukocytes
J. Biochem.
102
1083-1088
1987
Sus scrofa
Kurzban, G.P.; Howarth, J.; Palmer, G.; Strobel, H.W.
NADPH-cytochrome P-450 reductase. Physical properties and redox behavior in the absence of the FAD moiety
J. Biol. Chem.
265
12272-12279
1990
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Laporte, F.; Doussiere, J.; Vignais, P.V.
Properties of the NADPH dehydrogenase component of the oxidase complex from rabbit peritoneal neutrophils: reconstitution of an oxidase activity with the dehydrogenase component and a membrane extract
Biochem. Biophys. Res. Commun.
167
790-797
1990
Oryctolagus cuniculus
Laporte, F.; Doussiere, J.; Vignais, P.V.
Characterization of multiple active forms of the NADPH dehydrogenase component of the oxidase complex from rabbit peritoneal neutrophils by photolabeling with an arylazido derivative of NADP+
Biochem. Biophys. Res. Commun.
168
78-84
1990
Oryctolagus cuniculus
Vibet, A.; Dintinger, T.; Maboundou, J.C.; Gaillard, J.L.; Divoux, D.; Silberzahn, P.
Estrogen synthetase in the horse. Comparison of equine placental and rat liver NADPH-cytrochrome c (P-450) reductase activities
FEBS Lett.
261
31-34
1990
Equus caballus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Benveniste, I.; Lesot, A.; Hasenfratz, M.; Durst, F.
Immunochemical characterization of NADPH-cytochrome P-450 reductase from Jerusalem artichoke and other higher plants
Biochem. J.
259
847-853
1989
Saccharomyces cerevisiae, Helianthus tuberosus, Embryophyta, Locusta migratoria migratorioides, Rattus norvegicus, Sus scrofa
Kurokawa, T.; Fukumori, Y.; Yamanaka, T.
Purification of a flavoprotein having NADPH-cytochrome c reductase and transhydrogenase activities from Nitrobacter winogradskyi and its molecular and enzymatic properties
Arch. Microbiol.
148
95-99
1987
Nitrobacter winogradskyi
-
Ardies, C.M.; Lasker, J.M.; Bloswick, B.P.; Lieber, C.S.
Purification of NADPH:cytochrome c (cytochrome P-450) reductase from hamster liver microsomes by detergent extraction and affinity chromatography
Anal. Biochem.
162
39-46
1987
Mesocricetus auratus, Rattus norvegicus
Benveniste, I.; Gabriac, B.; Durst, F.
Purification and characterization of the NADPH-cytochrome P-450 (cytochrome c) reductase from higher-plant microsomal fraction
Biochem. J.
235
365-373
1986
Helianthus tuberosus
Takahashi, N.; Saito, T.; Goda, Y.; Tomita, K.
Characterization of microsomal NADPH-dependent aldehyde reductase from rat brain
J. Biochem.
99
513-519
1986
Rattus norvegicus, Rattus norvegicus Wistar
Kuwada, M.; Ohsawa, Y.; Horie, S.
Purification of NADPH-cytochrome c reductase from swine testis microsomes by chromatofocusing and characterization of the purified reductase
Biochim. Biophys. Acta
830
45-51
1985
Sus scrofa
Kuwahara, T.; White, R.A.; Agosin, M.
A cytosolic FAD-containing enzyme catalyzing cytochrome c reduction in Trypanosoma cruzi. I. Purification and some properties
Arch. Biochem. Biophys.
239
18-28
1985
Trypanosoma cruzi
Laurila, H.; K. ppeli, O.; Fiechter, A.
The cytochrome P450-containing monooxygenase of Trichosporon cutaneum: occurrence and properties
Arch. Microbiol.
140
257-259
1984
Cutaneotrichosporon cutaneum
Sakane, F.; Takahashi, K.; Koyama, J.
Purification and characterization of a membrane-bound NADPH-cytochrome c reductase capable of catalyzing menadione-dependent O2- formation in guinea pig polymorphonuclear leukocytes
J. Biochem.
96
671-678
1984
Cavia porcellus
Sierralta, W.D.; Szendro, P.I.
Characterization of microsomal subfractions from porcine endometrium cells
Hoppe-Seyler's Z. Physiol. Chem.
364
1329-1335
1983
Sus scrofa
Shephard, E.A.; Pike, S.F.; Rabin, B.R.; Phillips, I.R.
A rapid one-step purification of NADPH-cytochrome c (P-450) reductase from rat liver microsomes
Anal. Biochem.
129
430-433
1983
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Jayanthi, C.R.; Madyastha, P.; Madyastha, K.M.
Microsomal 11alpha-hydroxylation of progesterone in Aspergillus ochraceus: Part I: Characterization of the hydroxylase system
Biochem. Biophys. Res. Commun.
106
1262-1268
1982
Aspergillus ochraceus
Kamimura, K.; Tsuchiya, E.; Miyakawa, T.; Fuki, S.; Hirata, A.
Isolation and characterization of the nuclei from Saccharomyces cerevisiae
Curr. Microbiol.
6
175-180
1981
Saccharomyces cerevisiae
-
Bertrand, J.C.; Gilewicz, M.; Bazin, H.; Azoulay, E.
Purified detergent-solubilized NADPH-cytochrome c (P-450) reductase from Candida tropicalis grown on alkanes
Biochem. Biophys. Res. Commun.
94
889-893
1980
Candida tropicalis
Crankshaw, D.L.; Hetnarski, K.; Wilkinson, C.F.
Purification and characterization of NADPH--cytochrome c reductase from the midgut of the southern armyworm (Spodoptera eridania)
Biochem. J.
181
593-605
1979
Rattus norvegicus, Spodoptera eridania, Rattus norvegicus Sprague-Dawley
Bertrand, J.C.; Gilewicz, M.; Bazin, H.; Zacek, M.; Azoulay, E.
Partial purification of cytochrome P-450 of Candida tropicalis and reconstitution of hydroxylase activity
FEBS Lett.
105
143-146
1979
Candida tropicalis
Tryon, E.; Cress, M.C.; Hamada, M.; Kuby, S.A.
Studies on NADPH-cytochrome c reductase I: Isolation and several properties of the crystalline enzyme from ale yeast
Arch. Biochem. Biophys.
197
104-118
1979
Saccharomyces cerevisiae
Madyastha, K.M.; Coscia, C.J.
Detergent-solubilized NADPH-cytochrome c(P-450) reductase from the higher plant, Catharanthus roseus. Purification and characterization
J. Biol. Chem.
254
2419-2427
1979
Catharanthus roseus
Kulkoski, J.A.; Weber, J.L.; Ghazarian, J.G.
NADPH-cytochrome c reductase in outer membrane of kidney mitochondria. Purification and properties
Arch. Biochem. Biophys.
192
539-547
1979
Gallus gallus
Bertrand, J.C.; Bazin, H.; Zacek, M.; Gilewicz, M.; Azoulay, E.
NADPH-cytochrome c reductase of Candida tropicalis grown on alkane
Eur. J. Biochem.
93
237-243
1979
Candida tropicalis
Zimmermann, J.J.; Kasper, C.B.
Immunological and biochemical characterization of nuclear envelope reduced nicotinamide adenine dinucleotide phosphate-cytochrome c oxidoreductase
Arch. Biochem. Biophys.
190
726-735
1978
Rattus norvegicus
Kubota, S.; Yoshida, Y.; Kumaoka, H.; Furumichi, A.
Studies on the microsomal electron-transport system of anaerobically grown yeast. V. Purification and characterization of NADPH-cytochrome c reductase
J. Biochem.
81
197-205
1977
Saccharomyces cerevisiae
Yasukochi, Y.; Masters, B.S.S.
Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography
J. Biol. Chem.
251
5337-5344
1976
Rattus norvegicus, Sus scrofa
Arinc, E.; Philpot, R.M.
Preparation and properties of partially purified pulmonary cytochrome P-450 from rabbits
J. Biol. Chem.
251
3213-3220
1976
Oryctolagus cuniculus
Masters, B.S.S.; Prough, R.A.; Kamin, H.
Properties of the stable aerobic and anaerobic half-reduced states of NADPH-cytochrome c reductase
Biochemistry
14
607-613
1975
Rattus norvegicus, Sus scrofa
Fan, L.L.; Masters, B.S.S.
Properties of purified kidney microsomal NADPH-cytochrome c reductase
Arch. Biochem. Biophys.
165
665-671
1974
Sus scrofa
Teschke, R.; Hasumura, Y.; Lieber, C.S.
Hepatic microsomal ethanol-oxidizing system: solubilization, isolation, and characterization
Arch. Biochem. Biophys.
163
404-415
1974
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Betz, G.; Roper, M.; Tsai, P.
Steroid 17,20-lyase from testis microsomes: participation of NADPH cytochrome c reductase
Arch. Biochem. Biophys.
163
318-323
1974
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Iyanagi, T.
Some properties of kidney cortex and splenic microsomal NADPH-cytochrome c reductase
FEBS Lett.
46
51-54
1974
Sus scrofa
Golf, S.W.; Graef, V.; Staudinger, H.
Solubilization and purification of the NADPH-cytochrome reductase from rat liver microsomes
Hoppe-Seyler's Z. Physiol. Chem.
355
1063-1069
1974
Rattus norvegicus, Rattus norvegicus Wistar
Yoshida, Y.; Kumaoka, H.; Sato, R.
Studies on the microsomal electron-transport system of anaerobically grown yeast. I. Intracellular localization and characterization
J. Biochem.
75
1201-1210
1974
Saccharomyces cerevisiae
Ichihara, K.; Kusunose, E.; Kusunose, M.
Some properties of NADPH-cytochrome c reductase reconstitutively active in fatty-acid omega-hydroxylation
Eur. J. Biochem.
38
463-472
1973
Sus scrofa
Iyanagi, T.; Mason, H.S.
Some properties of hepatic reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase
Biochemistry
12
2297-2308
1973
Oryctolagus cuniculus
Poole, R.K.; Nicholl, W.G.; Howells, L.; Lloyd, D.
The microsomal fraction from Tetrahymena pyriformis strain ST: characterization and subfractionation
J. Gen. Microbiol.
68
283-294
1971
Tetrahymena pyriformis
Omura, T.; Takesue, S.
A new method for simultaneous purification of cytochrome b5 and NADPH-cytochrome c reductase from rat liver microsomes
J. Biochem.
67
249-257
1970
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Aoyama, Y.; Yoshida, Y.; Kubota, S.; Kamaoka, H.; Furumichi, A.
NADPH-cytochrome P-450 reductase of yeast microsomes
Arch. Biochem. Biophys.
185
362-369
1978
Saccharomyces cerevisiae
Cooper, M.B.; Craft, J.A.; Estall, M.R.; Rabin, B.R.
Asymmetric distribution of cytochrome P-450 and NADPH-cytochrome P-450 (cytochrome c) reductase in vesicles from smooth endoplasmic reticulum of rat liver
Biochem. J.
190
737-746
1980
Rattus norvegicus
Mayer, R.T.; Durrant, J.L.
Purified NADPH cytochrome P-450 reductase. Interaction with hepatic microsomes and phospholipid vesicles
J. Biol. Chem.
254
4177-4185
1979
Musca domestica
Osawa, Y.; Higashiyama, T.; Nakamura, T.
Species specificity of estrogen biosynthesis in pregnancy. Immunochemical difference of placental NADPH-cytochrome c (P-450) reductase in human, baboon and horse
J. Steroid Biochem.
15
449-452
1981
Homo sapiens
Yasukochi, Y.; Masters, B.S.S.
Tetramer-dimer dissociation in homoglobin and the Bohr effect
J. Biol. Chem.
251
5537-5544
1976
Rattus norvegicus
Masters, B.S.S.; Williams, C.H.; Kamin, H.
Preparation and properties of microsomal TPNH-cytochrome c reductase from pig liver
Methods Enzymol.
10
565-573
1967
Sus scrofa
-
Maisterrena, B.; Comte, J.; Gautheron, D.C.
Purification of pig heart mitochondrial membranes, enzymatic and morphological characterization as compared to microsomes
Biochim. Biophys. Acta
367
115-126
1974
Sus scrofa
Mull, R.H.; Voigt, T.; Flemming, K.
Characterization of microsomal electron transport components from control, phenobarbital, and 3-methylcholantrene treated mice: I. Distribution of electron transport components in ammonium sulfate fractions from mouse liver microsomes
Biochem. Biophys. Res. Commun.
64
1098-1106
1975
Mus musculus, Mus musculus NMRI/Kisslegg
Day, D.A.; Wiskich, J.T.
Isolation and properties of the outer membrane of plant mitochondria
Arch. Biochem. Biophys.
171
117-123
1975
Brassica rapa
Erecinska, M.
Cytochrome c Interaction with membranes, formylated cytochrome c1
Arch. Biochem. Biophys.
169
199-208
1975
Rattus norvegicus
Bowles, D.J.; Kauss, H.
Characterization, enzymatic and lectin properties of isolated membranes from Phaseolus aureus
Biochim. Biophys. Acta
443
360-374
1976
Vigna radiata var. radiata
Gilkes, N.R.; Weeks, G.
The purification and characterization of Dictyostelium discoideum plasma membranes
Biochim. Biophys. Acta
464
142-156
1977
Dictyostelium discoideum
Gilkes, N.R.; Weeks, G.
An improved procedure for the purification of plasma membranes from Dictyostelium discoideum
Can. J. Biochem.
55
1233-1236
1977
Dictyostelium discoideum
Mull, R.H.; Schgaguler, M.; Mnig, H.; Voigt, T.; Flemming, K.
Characterization of microsomal electron transport components from control, phenobarbital- and 3-methylcholantrene-treated mice, III. Improved resolution and quantitation of major components in ammonium sulfate fractions from total liver microsomes
Biochim. Biophys. Acta
462
671-688
1977
Mus musculus, Mus musculus NMRI/Kisslegg
Yoshida, Y.; Aoyama, Y.; Kumaoka, H.; Kubota, S.
A highly purified preparation of cytochrome P-450 from microsomes of anaerobically grown yeast
Biochem. Biophys. Res. Commun.
78
1005-1010
1977
Saccharomyces cerevisiae
Dialameh, G.H.
Isolation and partial purification of cytochrome-P-450 from induced rat liver
Biochem. Biophys. Res. Commun.
81
19-23
1978
Rattus norvegicus
Yoshida, T.; Kikuchi, G.
Purification and properties of heme oxygenase from rat liver microsomes
J. Biol. Chem.
254
4487-4491
1979
Sus scrofa
Kitada, M.; Yamazaki, C.; Hirota, K.; Kitagawa, H.
Purification of cytochrome P-450 from liver microsomes of phenobarbital-treated guinea pigs
Biochem. Biophys. Res. Commun.
93
1020-1026
1980
Cavia porcellus
Hara, T.; Taniguchi, M.
Relationship between changes in properties and contents of riboflavin derivatives of NADPH-cytochrome P-450 reductase in the liver microsomes of riboflavin-deficient rats
J. Biochem.
97
473-482
1985
Rattus norvegicus, Rattus norvegicus Wistar
Gut, J.; Kawato, S.; Cherry, R.J.; Winterhalter, K.H.; Richter, C.
Lipid peroxidation decreases the rotational mobility of cytochrome P-450 in rat liver microsomes
Biochim. Biophys. Acta
817
217-228
1985
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Lindeskog, P.; Haaparanta, T.; Norgard, M.; Glaumann, H.; Hansson, T.; Gustafsson J.
Isolation of rat intestinal microsomes: Partial characterisation of mucosal cytochrome P-450
Arch. Biochem. Biophys.
244
492-501
1986
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Dupuy, C.; Kaniewski, J.; Deme, D.; Pommier, J.; Virion, A.
NADPH-dependent H2O2 generation catalyzed by thyroid plasma membranes
Eur. J. Biochem.
185
597-603
1989
Sus scrofa
Shoun, H.; Sudo, Y.; Sato, K.; Beppu, T.
Components of the Cytochrome P-450 Monooxygenase System of the Fungus, Fusarium oxysporun: Conditions for Induction and Isolation of Cytochrome b5
Agric. Biol. Chem.
53
2153-2161
1989
Fusarium oxysporum
-
Arinc, E.; Sen, A.
Characterization of Cytochrome P450 dependent mixed-fuction oxidase system of gilthead seabream (sparus aurata; sparidae) liver
Comp. Biochem. Physiol. B
104
133-139
1993
Sparus aurata
-
Balvers, W.G.; Boersma, M.G.; Vervoort, J.; Ouwehand, A.; Rietjens, I.M.C.M.
A specific interaction between NADPH-cytochrome reductase and phosphatidylserine and phosphatidylinositol
Eur. J. Biochem.
218
1021-1029
1993
Rattus norvegicus, Rattus norvegicus Wistar
White, R.D.; Hahn, M.E.; Lockhart, W.L.; Stegeman, J.J.
Catalytic and Immunochemical Characterization of Hepatic Microsomal cytochromes P450 in Beluga Whale (Delphinapterus leucas)
Toxicol. Appl. Pharmacol.
126
45-57
1994
Delphinapterus leucas
Lee, C.A.; Kadwell, S.H.; Kost, T.A.; Serabjit-Singh, C.J.
CYP3A4 expressed by insect cells infected with a recombinant baculovirus containing both CYP3A4 and human NADPH-cytochrome P450 reductase is catalytically similar to human liver microsomal CYP3A4
Arch. Biochem. Biophys.
319
157-167
1995
Homo sapiens, Spodoptera frugiperda, Trichoplusia ni
Murataliev, M.B.; Feyereisen, R.
Functional interactions in cytochrome P450BM3. Fatty acid substrate binding alters electron-transfer properties of the flavoprotein domain
Biochemistry
35
15029-15037
1996
Priestia megaterium
McGuire, J.J.; Anderson, D.J.; McDonald, B.J.; Narayanasami, R.; Bennett, B.M.
Inhibition of NADPH-Cytochrome P450 Reductase and Glyceryl Trinitrate Biotransformation by Diphenyleneiodonium Sulfate
Biochem. Pharmacol.
56
881-893
1998
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Pritchard, M.P.; Glancey, M.J.; Blake, J.A.R.; Gilham, D.E.; Burchell, B.; Wolf, C.R.; Friedberg, T.
Functional co-expression of CYP2D6 and human NADPH-cytochrome P450 reductase in Escherichia coli
Pharmacogenetics
8
33-42
1998
Homo sapiens
Venkateswarlu, K.; Lamb, D.C.; Kelly, D.E.; Manning, N.J.; Kelly, S.L.
The N-terminal membrane domain of yeast NADPH-cytochrome P450 (CYP) oxidoreductase is not required for catalytic activity in steril biosynthesis or in reconstitution of CYP activity
J. Biol. Chem.
273
4492-4496
1998
Saccharomyces cerevisiae, Homo sapiens, Saccharomyces cerevisiae JL20
Shen, A.L.; Porter, T.D.; Wilson, T.E.; Kasper, C.B.
Structural analysis of the FMN binding domain of NADPH-cytochrome P-450 oxidoreductase by site-directed mutagenesis
J. Biol. Chem.
264
7584-7589
1989
Rattus norvegicus
Shen, A.L.; Kasper, C.B.
Differential contributions of NADPH-Cytochrome P450 oxidoreductase FAD binding site residues to flavin binding and catalysis
J. Biol. Chem.
275
41087-41091
2000
Rattus norvegicus (P00388)
Menting, J.G.T.; Cornish, E.; Scopes, R.K.
Purification and Partial Characterization of NADPH-cytochrome c reductase from Petunia hybrida flowers
Plant Physiol.
106
643-650
1994
Petunia x hybrida
Stiborova, M.; Schmeiser, H.H.; Frei, E.
Oxidation of xenobiotics by plant microsomes, a reconstituted cytochrome P450 system and peroxidase: a comparative study
Phytochemistry
54
353-362
2000
Tulipa fosteriana
Kutty, R.K.; Maines, M.D.
Characterization of an NADH-dependent haem-degrading system in ox heart mitochondria
Biochem. J.
246
467-474
1987
Rattus norvegicus
Ichinose, H.; Wariishi, H.; Tanaka, H.
Identification and heterologous expression of the cytochrome P450 oxidoreductase from the white-rot basidiomycete Coriolus versicolor
Appl. Microbiol. Biotechnol.
59
658-664
2002
Trametes versicolor (Q8X1W0), Trametes versicolor, Trametes versicolor IFO 30340 (Q8X1W0)
Warrilow, A.G.; Lamb, D.C.; Kelly, D.E.; Kelly, S.L.
Phanerochaete chrysosporium NADPH-cytochrome P450 reductase kinetic mechanism
Biochem. Biophys. Res. Commun.
299
189-195
2002
Phanerodontia chrysosporium
Gutierrez, A.; Grunau, A.; Paine, M.; Munro, A.W.; Wolf, C.R.; Roberts, G.C.; Scrutton, N.S.
Electron transfer in human cytochrome P450 reductase
Biochem. Soc. Trans.
31
497-501
2003
Homo sapiens
Munro, A.W.; Noble, M.A.; Robledo, L.; Daff, S.N.; Chapman, S.K.
Determination of the redox properties of human NADPH-cytochrome P450 reductase
Biochemistry
40
1956-1963
2003
Homo sapiens
Gutierrez, A.; Munro, A.W.; Grunau, A.; Wolf, C.R.; Scrutton, N.S.; Roberts, G.C.
Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues
Eur. J. Biochem.
270
2612-2621
2003
Homo sapiens
Faist, V.; Lindenmeier, M.; Geisler, C.; Erbersdobler, H.F.; Hofmann, T.
Influence of molecular weight fractions isolated from roasted malt on the enzyme activities of NADPH-cytochrome c-reductase and glutathione-S-transferase in Caco-2 cells
J. Agric. Food Chem.
50
602-606
2002
Homo sapiens
Arinc, E.; Celik, H.
Biochemical characteristics of purified beef liver NADPH-cytochrome P450 reductase
J. Biochem. Mol. Toxicol.
16
286-297
2002
Bos taurus, Ovis aries
Makovec, T.; Breskvar, K.
Catalytic and immunochemical properties of NADPH-cytochrome P450 reductase from fungus Rhizopus nigricans
J. Steroid Biochem. Mol. Biol.
82
89-96
2002
Rhizopus stolonifer
Mohammed, A.; Agard, J.
The occurrence of NADPH-ferrihemoprotein reductase in Corbula caribea, from a natural oil seep at La Brea, Trinidad
Mar. Pollut. Bull.
48
784-789
2004
Corbula caribea
Gu, J.; Cui, H.; Behr, M.; Zhang, L.; Zhang, Q.Y.; Yang, W.; Hinson, J.A.; Ding, X.
In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa
Mol. Pharmacol.
67
623-630
2005
Mus musculus
Yamazaki, Y.; Fujita, K.; Nakayama, K.; Suzuki, A.; Nakamura, K.; Yamazaki, H.; Kamataki, T.
Establishment of ten strains of genetically engineered Salmonella typhimurium TA1538 each co-expressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase sensitive to various promutagens
Mutat. Res.
562
151-162
2004
Homo sapiens
Osman, A.M.; van Noort, P.C.M.
Activation of paraquat in the earthworm Allolobophora chlorotica is mediated by NAD(P)H-cytochrome c reductase activities
Pestic. Biochem. Physiol.
79
101-110
2004
Allolobophora chlorotica
-
Dudka, J.
Decrease in NADPH-cytochrome P450 reductase activity of the human heart, liver and lungs in the presence of alpha-lipoic acid
Ann. Nutr. Metab.
50
121-125
2006
Homo sapiens
Dudka, J.; Jodynis-Liebert, J.; Korobowicz, E.; Burdan, F.; Korobowicz, A.; Szumilo, J.; Tokarska, E.; Klepacz, R.; Murias, M.
Activity of NADPH-cytochrome P-450 reductase of the human heart, liver and lungs in the presence of (-)-epigallocatechin gallate, quercetin and resveratrol: an in vitro study
Basic Clin. Pharmacol. Toxicol.
97
74-79
2005
Homo sapiens
Vatsis, K.P.; Coon, M.J.
Oxidative aldehyde deformylation catalyzed by NADPH-cytochrome P450 reductase and the flavoprotein domain of neuronal nitric oxide synthase
Biochem. Biophys. Res. Commun.
337
1107-1111
2005
Rattus norvegicus
Bonina, T.A.; Gilep, A.A.; Estabrook, R.W.; Usanov, S.A.
Engineering of proteolytically stable NADPH-cytochrome P450 reductase
Biochemistry
70
357-365
2005
Rattus norvegicus
Begleiter, A.; Leith, M.K.; Patel, D.; Hasinoff, B.B.
Role of NADPH cytochrome P450 reductase in activation of RH1
Cancer Chemother. Pharmacol.
60
713-723
2007
Homo sapiens
Kostrzewa-Nowak, D.; Paine, M.J.; Korytowska, A.; Serwatka, K.; Piotrowska, S.; Wolf, C.R.; Tarasiuk, J.
Bioreductive activation of mitoxantrone by NADPH cytochrome P450 reductase. Implications for increasing its ability to inhibit the growth of sensitive and multidrug resistant leukaemia HL60 cells
Cancer Lett.
245
252-262
2007
Homo sapiens
Hasinoff, B.B.; Begleiter, A.
The reductive activation of the antitumor drug RH1 to its semiquinone free radical by NADPH cytochrome P450 reductase and by HCT116 human colon cancer cells
Free Radic. Res.
40
974-978
2006
Homo sapiens
Higashimoto, Y.; Sato, H.; Sakamoto, H.; Takahashi, K.; Palmer, G.; Noguchi, M.
The reactions of heme- and verdoheme-heme oxygenase-1 complexes with FMN-depleted NADPH-cytochrome P450 reductase. Electrons required for verdoheme oxidation can be transferred through a pathway not involving FMN
J. Biol. Chem.
281
31659-31667
2006
Rattus norvegicus
Liu, K.H.; Kim, M.J.; Jeon, B.H.; Shon, J.H.; Cha, I.J.; Cho, K.H.; Lee, S.S.; Shin, J.G.
Inhibition of human cytochrome P450 isoforms and NADPH-CYP reductase in vitro by 15 herbal medicines, including Epimedii herba
J. Clin. Pharm. Ther.
31
83-91
2006
Homo sapiens
Mori, T.; Yamazaki, A.; KInoshita, T.; Imaoka, S.
Purification of NADPH-P450 reductase (NPR) from Xenopus laevis and the developmental change in NPR expression
Life Sci.
79
247-251
2006
Xenopus laevis
Cheng, J.; Wan, D.F.; Gu, J.R.; Gong, Y.; Yang, S.L.; Hao, D.C.; Yang, L.
Establishment of a yeast system that stably expresses human cytochrome P450 reductase: application for the study of drug metabolism of cytochrome P450s in vitro
Protein Expr. Purif.
47
467-476
2006
Homo sapiens
Yim, S.K.; Jung, H.C.; Pan, J.G.; Kang, H.S.; Ahn, T.; Yun, C.H.
Functional expression of mammalian NADPH-cytochrome P450 oxidoreductase on the cell surface of Escherichia coli
Protein Expr. Purif.
49
292-298
2006
Rattus norvegicus
Lamb, D.C.; Kim, Y.; Yermalitskaya, L.V.; Yermalitsky, V.N.; Lepesheva, G.I.; Kelly, S.L.; Waterman, M.R.; Podust, L.M.
A second FMN binding site in yeast NADPH-cytochrome P450 reductase suggests a mechanism of electron transfer by diflavin reductases
Structure
14
51-61
2006
Saccharomyces cerevisiae (P16603)
Bozcaarmutlu, A.; Arinc, E.
Effect of mercury, cadmium, nickel, chromium and zinc on kinetic properties of NADPH-cytochrome P450 reductase purified from leaping mullet (Liza saliens)
Toxicol. in Vitro
21
408-416
2006
Chelon saliens
Li, L.; Porter, T.D.
Hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase
Arch. Biochem. Biophys.
461
76-84
2007
Mus musculus
Kranendonk, M.; Marohnic, C.C.; Panda, S.P.; Duarte, M.P.; Oliveira, J.S.; Masters, B.S.; Rueff, J.
Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley-Bixler syndrome variants of cytochrome P450 oxidoreductase
Arch. Biochem. Biophys.
475
93-99
2008
Homo sapiens
Sarapusit, S.; Xia, C.; Misra, I.; Rongnoparut, P.; Kim, J.J.
NADPH-cytochrome P450 oxidoreductase from the mosquito Anopheles minimus: kinetic studies and the influence of Leu86 and Leu219 on cofactor binding and protein stability
Arch. Biochem. Biophys.
477
53-59
2008
Anopheles minimus
Higashimoto, Y.; Sugishima, M.; Sato, H.; Sakamoto, H.; Fukuyama, K.; Palmer, G.; Noguchi, M.
Mass spectrometric identification of lysine residues of heme oxygenase-1 that are involved in its interaction with NADPH-cytochrome P450 reductase
Biochem. Biophys. Res. Commun.
367
852-858
2008
Rattus norvegicus (P00388)
Guise, C.P.; Wang, A.T.; Theil, A.; Bridewell, D.J.; Wilson, W.R.; Patterson, A.V.
Identification of human reductases that activate the dinitrobenzamide mustard prodrug PR-104A: a role for NADPH:cytochrome P450 oxidoreductase under hypoxia
Biochem. Pharmacol.
74
810-820
2007
Homo sapiens
Inui, H.; Maeda, A.; Ohkawa, H.
Molecular characterization of specifically active recombinant fused enzymes consisting of CYP3A4, NADPH-cytochrome P450 oxidoreductase, and cytochrome b5
Biochemistry
46
10213-10221
2007
Saccharomyces cerevisiae
Huber, W.J.; Backes, W.L.
Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase
Biochemistry
46
12212-12219
2007
Rattus norvegicus
Grunau, A.; Geraki, K.; Grossmann, J.G.; Gutierrez, A.
Conformational dynamics and the energetics of protein-ligand interactions: role of interdomain loop in human cytochrome P450 reductase
Biochemistry
46
8244-8255
2007
Homo sapiens
Gonzalez-Kristeller, D.C.; Farage, L.; Fiorini, L.C.; Loomis, W.F.; da Silva, A.M.
The P450 oxidoreductase, RedA, controls development beyond the mound stage in Dictyostelium discoideum
BMC Dev. Biol.
8
8-8
2008
Dictyostelium discoideum
Haiman, C.A.; Setiawan, V.W.; Xia, L.Y.; Le Marchand, L.; Ingles, S.A.; Ursin, G.; Press, M.F.; Bernstein, L.; John, E.M.; Henderson, B.E.
A variant in the cytochrome p450 oxidoreductase gene is associated with breast cancer risk in African Americans
Cancer Res.
67
3565-3568
2007
Homo sapiens
Weng, Y.; Fang, C.; Turesky, R.J.; Behr, M.; Kaminsky, L.S.; Ding, X.
Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice
Cancer Res.
67
7825-7832
2007
Mus musculus
Cherala, G.; Shapiro, B.H.; Dmello, A.P.
Effect of perinatal low protein diets on the ontogeny of select hepatic cytochrome p450 enzymes and cytochrome p450 reductase in the rat
Drug Metab. Dispos.
35
1057-1063
2007
Rattus norvegicus
Fang, C.; Gu, J.; Xie, F.; Behr, M.; Yang, W.; Abel, E.D.; Ding, X.
Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity
Drug Metab. Dispos.
36
1722-1728
2008
Mus musculus
Reed, J.R.; Brignac-Huber, L.M.; Backes, W.L.
Physical incorporation of NADPH-cytochrome P450 reductase and cytochrome P450 into phospholipid vesicles using glycocholate and Bio-Beads
Drug Metab. Dispos.
36
582-588
2008
Oryctolagus cuniculus
Flueck, C.E.; Pandey, A.V.; Huang, N.; Agrawal, V.; Miller, W.L.
P450 oxidoreductase deficiency - a new form of congenital adrenal hyperplasia
Endocr. Dev.
13
67-81
2008
Homo sapiens
Brenner, S.; Hay, S.; Munro, A.W.; Scrutton, N.S.
Inter-flavin electron transfer in cytochrome P450 reductase - effects of solvent and pH identify hidden complexity in mechanism
FEBS J.
275
4540-4557
2008
Homo sapiens
Van Bogaert, I.N.; Develter, D.; Soetaert, W.; Vandamme, E.J.
Cloning and characterization of the NADPH cytochrome P450 reductase gene (CPR) from Candida bombicola
FEMS Yeast Res.
7
922-928
2007
Starmerella bombicola (A5Y0M3), Starmerella bombicola
Yao, H.T.; Chang, Y.W.; Lan, S.J.; Yeh, T.K.
The inhibitory effect of tannic acid on cytochrome P450 enzymes and NADPH-CYP reductase in rat and human liver microsomes
Food Chem. Toxicol.
46
645-653
2008
Homo sapiens, Rattus norvegicus
Wang, Y.; Gray, J.P.; Mishin, V.; Heck, D.E.; Laskin, D.L.; Laskin, J.D.
Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity
Free Radic. Biol. Med.
44
1169-1179
2008
Rattus norvegicus
Flck, C.E.; Nicolo, C.; Pandey, A.V.
Clinical, structural and functional implications of mutations and polymorphisms in human NADPH P450 oxidoreductase
Fundam. Clin. Pharmacol.
21
399-410
2007
Homo sapiens
Lah, L.; Krasevec, N.; Trontelj, P.; Komel, R.
High diversity and complex evolution of fungal cytochrome P450 reductase: cytochrome P450 systems
Fungal Genet. Biol.
45
446-458
2008
Eremothecium gossypii, Aspergillus fumigatus, Aspergillus nidulans, Aspergillus niger, Aspergillus oryzae, Aspergillus terreus, Botrytis cinerea, Saccharomyces cerevisiae, Candida albicans, Debaryomyces hansenii, [Candida] glabrata, Yarrowia lipolytica, Chaetomium globosum, Coccidioides immitis, Fusarium graminearum, Kluyveromyces lactis, Pyricularia grisea, Neurospora crassa, Phytophthora sojae, Rhizopus arrhizus, Sclerotinia sclerotiorum, Ustilago maydis, Parastagonospora nodorum, Phytophthora ramorum, Schizosaccharomyces pombe (P36587), Phanerodontia chrysosporium (Q9HDG2)
Bozcaarmutlu, A.
Mechanism of inhibition of purified leaping mullet (Liza saliens) NADPH-cytochrome P450 reductase by toxic metals: aluminum and thallium
J. Biochem. Mol. Toxicol.
21
340-347
2007
Chelon saliens
Mao, W.; Rupasinghe, S.G.; Zangerl, A.R.; Berenbaum, M.R.; Schuler, M.A.
Allelic variation in the Depressaria pastinacella CYP6AB3 protein enhances metabolism of plant allelochemicals by altering a proximal surface residue and potential interactions with cytochrome P450 reductase
J. Biol. Chem.
282
10544-10552
2007
Musca domestica
Scott, R.R.; Gomes, L.G.; Huang, N.; Van Vliet, G.; Miller, W.L.
Apparent manifesting heterozygosity in P450 oxidoreductase deficiency and its effect on coexisting 21-hydroxylase deficiency
J. Clin. Endocrinol. Metab.
92
2318-2322
2007
Homo sapiens
Kaewpa, D.; Boonsuepsakul, S.; Rongnoparut, P.
Functional expression of mosquito NADPH-cytochrome P450 reductase in Escherichia coli
J. Econ. Entomol.
100
946-953
2007
Anopheles minimus (A4ZIT2)
Mutch, D.M.; Klocke, B.; Morrison, P.; Murray, C.A.; Henderson, C.J.; Seifert, M.; Williamson, G.
The disruption of hepatic cytochrome P450 reductase alters mouse lipid metabolism
J. Proteome Res.
6
3976-3984
2007
Mus musculus
Portal, P.; Villamil, S.F.; Alonso, G.D.; De Vas, M.G.; Flawia, M.M.; Torres, H.N.; Paveto, C.
Multiple NADPH-cytochrome P450 reductases from Trypanosoma cruzi suggested role on drug resistance
Mol. Biochem. Parasitol.
160
42-51
2008
Trypanosoma cruzi (Q003G7), Trypanosoma cruzi (Q003G8), Trypanosoma cruzi (Q0MRD4), Trypanosoma cruzi
Dhir, V.; Ivison, H.E.; Krone, N.; Shackleton, C.H.; Doherty, A.J.; Stewart, P.M.; Arlt, W.
Differential inhibition of CYP17A1 and CYP21A2 activities by the P450 oxidoreductase mutant A287P
Mol. Endocrinol.
21
1958-1968
2007
Homo sapiens
Brankova, L.; Ivanov, S.; Alexieva, V.
The induction of microsomal NADPH:cytochrome P450 and NADH:cytochrome b5 reductases by long-term salt treatment of cotton (Gossypium hirsutum L.) and bean (Phaseolus vulgaris L.) plants
Plant Physiol. Biochem.
45
691-695
2007
Gossypium hirsutum, Phaseolus vulgaris
Huang, N.; Agrawal, V.; Giacomini, K.M.; Miller, W.L.
Genetics of P450 oxidoreductase: sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations
Proc. Natl. Acad. Sci. USA
105
1733-1738
2008
Homo sapiens
Hamann, T.; Mller, B.L.
Improved cloning and expression of cytochrome P450s and cytochrome P450 reductase in yeast
Protein Expr. Purif.
56
121-127
2007
Sorghum bicolor
Yim, S.K.; Jung, H.C.; Yun, C.H.; Pan, J.G.
Functional expression in Bacillus subtilis of mammalian NADPH-cytochrome P450 oxidoreductase and its spore-display
Protein Expr. Purif.
63
5-11
2008
Rattus norvegicus
Tyden, E.; Olsen, L.; Tallkvist, J.; Tjaelve, H.; Larsson, P.
Cytochrome P450 3A, NADPH cytochrome P450 reductase and cytochrome b5 in the upper airways in horse
Res. Vet. Sci.
85
80-85
2008
Equus caballus
Stiborova, M.; Arlt, V.M.; Henderson, C.J.; Wolf, C.R.; Kotrbova, V.; Moserova, M.; Hudecek, J.; Phillips, D.H.; Frei, E.
Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouse
Toxicol. Appl. Pharmacol.
226
318-327
2008
Mus musculus
Martinez, V.G.; Williams, K.J.; Stratford, I.J.; Clynes, M.; OConnor, R.
Overexpression of cytochrome P450 NADPH reductase sensitises MDA 231 breast carcinoma cells to 5-fluorouracil: possible mechanisms involved
Toxicol. In Vitro
22
582-588
2008
Homo sapiens
Girvan, H.M.; Toogood, H.; Littleford, R.E.; Seward, H.E.; Smith, W.E.; Ekanem, I.; Leys, D.; Cheesman, M.; Munro, A.W.
Novel heme coordination variants of flavocytochrome P450 BM3
Biochem. J.
417
65-76
2009
Priestia megaterium (P14779), Priestia megaterium
Aigrain, L.; Pompon, D.; Truan, G.; Morera, S.
Cloning, purification, crystallization and preliminary X-ray analysis of a chimeric NADPH-cytochrome P450 reductase
Acta Crystallogr. Sect. F
65
210-212
2009
Saccharomyces cerevisiae /Homo sapiens (P16603)
Mast, N.; Liao, W.L.; Pikuleva, I.A.; Turko, I.V.
Combined use of mass spectrometry and heterologous expression for identification of membrane-interacting peptides in cytochrome P450 46A1 and NADPH-cytochrome P450 oxidoreductase
Arch. Biochem. Biophys.
483
81-89
2009
Rattus norvegicus (P00388)
Hall, C.N.; Keynes, R.G.; Garthwaite, J.
Cytochrome P450 oxidoreductase participates in nitric oxide consumption by rat brain
Biochem. J.
419
411-418
2009
Rattus norvegicus
Huber III, W.J.; Scruggs, B.A.; Backes, W.L.
C-Terminal membrane spanning region of human heme oxygenase-1 mediates a time-dependent complex formation with cytochrome P450 reductase
Biochemistry
48
190-197
2009
Rattus norvegicus
Kim, D.H.; Yim, S.K.; Kim, K.H.; Ahn, T.; Yun, C.H.
Continuous spectrofluorometric and spectrophotometric assays for NADPH-cytochrome P450 reductase activity using 5-cyano-2,3-ditolyl tetrazolium chloride
Biotechnol. Lett.
31
271-275
2009
Rattus norvegicus
Locuson, C.W.; Ethell, B.T.; Voice, M.; Lee, D.; Feenstra, K.L.
Evaluation of Escherichia coli membrane preparations of canine CYP1A1, 2B11, 2C21, 2C41, 2D15, 3A12, and 3A26 with coexpressed canine cytochrome P450 reductase
Drug Metab. Dispos.
37
457-461
2009
Canis lupus familiaris
Gan, L.; von Moltke, L.L.; Trepanier, L.A.; Harmatz, J.S.; Greenblatt, D.J.; Court, M.H.
Role of NADPH-cytochrome P450 reductase and cytochrome-b5/NADH-b5 reductase in variability of CYP3A activity in human liver microsomes
Drug Metab. Dispos.
37
90-96
2009
Homo sapiens
Aigrain, L.; Pompon, D.; Morera, S.; Truan, G.
Structure of the open conformation of a functional chimeric NADPH cytochrome P450 reductase
EMBO Rep.
10
742-747
2009
Homo sapiens, Saccharomyces cerevisiae (P16603)
Hamdane, D.; Xia, C.; Im, S.C.; Zhang, H.; Kim, J.J.; Waskell, L.
Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450
J. Biol. Chem.
284
11374-11384
2009
Rattus norvegicus (P00388)
Iijima, S.; Ohishi, A.; Ohzeki, T.
Cytochrome P450 oxidoreductase deficiency with Antley-Bixler syndrome: steroidogenic capacities
J. Pediatr. Endocrinol. Metab.
22
469-475
2009
Homo sapiens
Schmidt, K.; Hughes, C.; Chudek, J.A.; Goodyear, S.R.; Aspden, R.M.; Talbot, R.; Gundersen, T.E.; Blomhoff, R.; Henderson, C.; Wolf, C.R.; Tickle, C.
Cholesterol metabolism: the main pathway acting downstream of cytochrome P450 oxidoreductase in skeletal development of the limb
Mol. Cell. Biol.
29
2716-2729
2009
Mus musculus
Guengerich, F.P.; Martin, M.V.; Sohl, C.D.; Cheng, Q.
Measurement of cytochrome P450 and NADPH-cytochrome P450 reductase
Nat. Protoc.
4
1245-1251
2009
Rattus norvegicus
Gomes, A.M.; Winter, S.; Klein, K.; Turpeinen, M.; Schaeffeler, E.; Schwab, M.; Zanger, U.M.
Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation
Pharmacogenomics
10
579-599
2009
Homo sapiens (P16435), Homo sapiens
Schwarz, H.; Liu, B.; Peters, S.; Barillas, W.; Beerhues, L.
Purification, cDNA cloning and functional expression of NADPH-cytochrome P450 reductase from Centaurium erythraea cell cultures
Plant Biol.
11
300-306
2009
Centaurium erythraea (Q6PLI6)
Eberle, D.; Ullmann, P.; Werck-Reichhart, D.; Petersen, M.
cDNA cloning and functional characterisation of CYP98A14 and NADPH:cytochrome P450 reductase from Coleus blumei involved in rosmarinic acid biosynthesis
Plant Mol. Biol.
69
239-253
2009
Coleus scutellarioides (C0Z3X6)
Inaoka, Y.; Yazawa, T.; Mizutani, T.; Kokame, K.; Kangawa, K.; Uesaka, M.; Umezawa, A.; Miyamoto, K.
Regulation of P450 oxidoreductase by gonadotropins in rat ovary and its effect on estrogen production
Reprod. Biol. Endocrinol.
6
62
2008
Homo sapiens (P16435), Homo sapiens, Rattus norvegicus (P00388)
Ivanov, A.S.; Gnedenko, O.V.; Molnar, A.A.; Archakov, A.I.; Podust, L.M.
FMN binding site of yeast NADPH-cytochrome P450 reductase exposed at the surface is highly specific
ACS Chem. Biol.
5
767-776
2010
Saccharomyces cerevisiae
Sarapusit, S.; Pethuan, S.; Rongnoparut, P.
Mosquito NADPH-cytochrome P450 oxidoreductase: kinetics and role of phenylalanine amino acid substitutions at leu86 and leu219 in CYP6AA3-mediated deltamethrin metabolism
Arch. Insect Biochem. Physiol.
73
232-244
2010
Anopheles minimus
Park, H.G.; Lim, Y.R.; Eun, C.Y.; Han, S.; Han, J.S.; Cho, K.S.; Chun, Y.J.; Kim, D.
Candida albicans NADPH-P450 reductase: expression, purification, and characterization of recombinant protein
Biochem. Biophys. Res. Commun.
396
534-538
2010
Candida albicans
Grinkova, Y.V.; Denisov, I.G.; Sligar, S.G.
Functional reconstitution of monomeric CYP3A4 with multiple cytochrome P450 reductase molecules in Nanodiscs
Biochem. Biophys. Res. Commun.
398
194-198
2010
Rattus norvegicus
Pandey, A.V.; Flueck, C.E.; Mullis, P.E.
Altered heme catabolism by heme oxygenase-1 caused by mutations in human NADPH cytochrome P450 reductase
Biochem. Biophys. Res. Commun.
400
374-378
2010
Homo sapiens
Farooq, Y.; Roberts, G.C.
Kinetics of electron transfer between NADPH-cytochrome P450 reductase and cytochrome P450 3A4
Biochem. J.
432
485-493
2010
Homo sapiens
Jang, H.H.; Jamakhandi, A.P.; Sullivan, S.Z.; Yun, C.H.; Hollenberg, P.F.; Miller, G.P.
Beta sheet 2-alpha helix C loop of cytochrome P450 reductase serves as a docking site for redox partners
Biochim. Biophys. Acta
1804
1285-1293
2010
Rattus norvegicus
Laursen, T.; Jensen, K.; Moller, B.L.
Conformational changes of the NADPH-dependent cytochrome P450 reductase in the course of electron transfer to cytochromes P450
Biochim. Biophys. Acta
1814
132-138
2011
Rattus norvegicus
Feidt, D.M.; Klein, K.; Nuessler, A.; Zanger, U.M.
RNA-interference approach to study functions of NADPH: cytochrome P450 oxidoreductase in human hepatocytes
Chem. Biodivers.
6
2084-2091
2009
Homo sapiens
Ellis, J.; Gutierrez, A.; Barsukov, I.L.; Huang, W.C.; Grossmann, J.G.; Roberts, G.C.
Domain motion in cytochrome P450 reductase: conformational equilibria revealed by NMR and small-angle X-ray scattering
J. Biol. Chem.
284
36628-36637
2009
Homo sapiens
Bumpus, N.N.; Hollenberg, P.F.
Cross-linking of human cytochrome P450 2B6 to NADPH-cytochrome P450 reductase: Identification of a potential site of interaction
J. Inorg. Biochem.
104
485-488
2010
Homo sapiens
Flueck, C.E.; Mullis, P.E.; Pandey, A.V.
Modeling of human P450 oxidoreductase structure by in silico mutagenesis and MD simulation
Mol. Cell. Endocrinol.
313
17-22
2009
Rattus norvegicus (P00388), Homo sapiens (P16435), Homo sapiens
Brignac-Huber, L.; Reed, J.R.; Backes, W.L.
Organization of NADPH-cytochrome P450 reductase and CYP1A2 in the endoplasmic reticulum - microdomain localization affects monooxygenase function
Mol. Pharmacol.
79
549-557
2011
Oryctolagus cuniculus
Jensen, K.; Moller, B.L.
Plant NADPH-cytochrome P450 oxidoreductases
Phytochemistry
71
132-141
2010
Ammi majus, Arabidopsis thaliana, Artemisia annua, Capsicum annuum, Catharanthus roseus, Centaurium erythraea, Chlamydomonas reinhardtii, Coleus scutellarioides, Eschscholzia californica, Glycine max, Gossypium hirsutum, Helianthus tuberosus, Hypericum androsaemum, Lotus japonicus, Ophiorrhiza pumila, Oryza sativa, Papaver somniferum, Petroselinum crispum, Physcomitrium patens, Pisum sativum, Populus trichocarpa x Populus deltoides, Pseudotsuga menziesii, Ricinus communis, Selaginella moellendorffii, Sorghum bicolor, Stevia rebaudiana, Taxus chinensis, Taxus cuspidata, Triticum aestivum, Vicia sativa, Vigna radiata, Vitis vinifera, Zea mays
Yang, C.Q.; Lu, S.; Mao, Y.B.; Wang, L.J.; Chen, X.Y.
Characterization of two NADPH: cytochrome P450 reductases from cotton (Gossypium hirsutum)
Phytochemistry
71
27-35
2010
Gossypium hirsutum (C0LLU4), Gossypium hirsutum (C0LLU5), Gossypium hirsutum
Gray, J.P.; Mishin, V.; Heck, D.E.; Laskin, D.L.; Laskin, J.D.
Inhibition of NADPH cytochrome P450 reductase by the model sulfur mustard vesicant 2-chloroethyl ethyl sulfide is associated with increased production of reactive oxygen species
Toxicol. Appl. Pharmacol.
247
76-82
2010
Homo sapiens, Mus musculus, Rattus norvegicus
Christensen, H.; Hestad, A.L.; Molden, E.; Mathiesen, L.
CYP3A5-mediated metabolism of midazolam in recombinant systems is highly sensitive to NADPH-cytochrome P450 reductase activity
Xenobiotica
41
1-5
2011
Homo sapiens
Girhard, M.; Tieves, F.; Weber, E.; Smit, M.S.; Urlacher, V.B.
Cytochrome P450 reductase from Candida apicola: versatile redox partner for bacterial P450s
Appl. Microbiol. Biotechnol.
97
1625-1635
2013
Starmerella apicola (H2ER12), Starmerella apicola, Starmerella apicola ATCC 96134 (H2ER12)
Im, S.C.; Waskell, L.
The interaction of microsomal cytochrome P450 2B4 with its redox partners, cytochrome P450 reductase and cytochrome b5
Arch. Biochem. Biophys.
507
144-153
2011
Homo sapiens
Iyanagi, T.; Xia, C.; Kim, J.J.
NADPH-cytochrome P450 oxidoreductase: prototypic member of the diflavin reductase family
Arch. Biochem. Biophys.
528
72-89
2012
Homo sapiens, Rattus norvegicus
Polusani, S.R.; Kar, R.; Riquelme, M.A.; Masters, B.S.; Panda, S.P.
Regulation of gap junction function and Connexin 43 expression by cytochrome P450 oxidoreductase (CYPOR)
Biochem. Biophys. Res. Commun.
411
490-495
2011
Homo sapiens, Mus musculus
Kenaan, C.; Zhang, H.; Shea, E.V.; Hollenberg, P.F.
Uncovering the role of hydrophobic residues in cytochrome P450-cytochrome P450 reductase interactions
Biochemistry
50
3957-3967
2011
Rattus norvegicus
Liu, S.; Liang, Q.M.; Huang, Y.J.; Yuan, X.; Zhou, W.W.; Qiao, F.; Cheng, J.; Gurr, G.M.; Zhu, Z.R.
Cloning, functional characterization, and expression profiles of NADPH-cytochrome P450 reductase gene from the Asiatic rice striped stem borer, Chilo suppressalis (Lepidoptera: Pyralidae)
Comp. Biochem. Physiol. B
166
225-231
2013
Chilo suppressalis (R4UB73)
Zhou, X.; Li, M.; Sheng, C.; Qiu, X.
NADPH-cytochrome P450 oxidoreductase from the chicken (Gallus gallus): sequence characterization, functional expression and kinetic study
Comp. Biochem. Physiol. C
153
53-59
2011
Gallus gallus (F1P2T2), Gallus gallus
Pottier, M.A.; Bozzolan, F.; Chertemps, T.; Jacquin-Joly, E.; Lalouette, L.; Siaussat, D.; Maibeche-Coisne, M.
Cytochrome P450s and cytochrome P450 reductase in the olfactory organ of the cotton leafworm Spodoptera littoralis
Insect Mol. Biol.
21
568-580
2012
Spodoptera littoralis
Xia, C.; Hamdane, D.; Shen, A.L.; Choi, V.; Kasper, C.B.; Pearl, N.M.; Zhang, H.; Im, S.C.; Waskell, L.; Kim, J.J.
Conformational changes of NADPH-cytochrome P450 oxidoreductase are essential for catalysis and cofactor binding
J. Biol. Chem.
286
16246-16260
2011
Rattus norvegicus (P00388)
DAgostino, J.; Ding, X.; Zhang, P.; Jia, K.; Fang, C.; Zhu, Y.; Spink, D.C.; Zhang, Q.Y.
Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes
J. Biol. Chem.
287
17777-17788
2012
Mus musculus
Lee, H.; Park, H.G.; Lim, Y.R.; Lee, I.S.; Kim, B.J.; Seong, C.H.; Chun, Y.J.; Kim, D.
Functional expression and characterization of recombinant NADPH-P450 reductase from Malassezia globosa
J. Microbiol. Biotechnol.
22
141-146
2012
Malassezia globosa (A8PYK0), Malassezia globosa
Manoj, K.M.; Gade, S.K.; Mathew, L.
Cytochrome P450 reductase: a harbinger of diffusible reduced oxygen species
PLoS ONE
5
e13272
2010
Homo sapiens
Rana, S.; Lattoo, S.K.; Dhar, N.; Razdan, S.; Bhat, W.W.; Dhar, R.S.; Vishwakarma, R.
NADPH-cytochrome P450 reductase: molecular cloning and functional characterization of two paralogs from Withania somnifera (L.) dunal
PLoS ONE
8
e57068
2013
Withania somnifera (D6P3J1), Withania somnifera (I1E3I6), Withania somnifera
Price, C.L.; Warrilow, A.G.; Parker, J.E.; Mullins, J.G.; Nes, W.D.; Kelly, D.E.; Kelly, S.L.
Novel substrate specificity and temperature-sensitive activity of Mycosphaerella graminicola CYP51 supported by the native NADPH cytochrome P450 reductase
Appl. Environ. Microbiol.
81
3379-3386
2015
Zymoseptoria tritici
Meints, C.E.; Parke, S.M.; Wolthers, K.R.
Proximal FAD histidine residue influences interflavin electron transfer in cytochrome P450 reductase and methionine synthase reductase
Arch. Biochem. Biophys.
547
18-26
2014
Homo sapiens
Whitelaw, D.A.; Tonkin, R.; Meints, C.E.; Wolthers, K.R.
Kinetic analysis of electron flux in cytochrome P450 reductases reveals differences in rate-determining steps in plant and mammalian enzymes
Arch. Biochem. Biophys.
584
107-115
2015
Arabidopsis thaliana, Homo sapiens, Artemisia annua
Mothersole, R.G.; Meints, C.E.; Louder, A.; Wolthers, K.R.
Role of active site loop in coenzyme binding and flavin reduction in cytochrome P450 reductase
Arch. Biochem. Biophys.
606
111-119
2016
Homo sapiens (P16435), Homo sapiens
Lehr, M.; Fabian, J.; Hanekamp, W.
Involvement of microsomal NADPH-cytochrome P450 reductase in metabolic reduction of drug ketones
Biopharm. Drug Dispos.
36
398-404
2015
Homo sapiens
Simtchouk, S.; Eng, J.L.; Meints, C.E.; Makins, C.; Wolthers, K.R.
Kinetic analysis of cytochrome P450 reductase from Artemisia annua reveals accelerated rates of NADH-dependent flavin reduction
FEBS J.
280
6627-6642
2013
Artemisia annua
Niu, G.; Zhao, S.; Wang, L.; Dong, W.; Liu, L.; He, Y.
Structure of the Arabidopsis thaliana NADPH-cytochrome P450 reductase 2 (ATR2) provides insight into its function
FEBS J.
284
754-765
2017
Arabidopsis thaliana
Shinkai, Y.; Nishihara, Y.; Amamiya, M.; Wakayama, T.; Li, S.; Kikuchi, T.; Nakai, Y.; Shimojo, N.; Kumagai, Y.
NADPH-cytochrome P450 reductase-mediated denitration reaction of 2,4,6-trinitrotoluene to yield nitrite in mammals
Free Radic. Biol. Med.
91
178-187
2016
Rattus norvegicus
Bhat, W.W.; Rana, S.; Dhar, N.; Razdan, S.; Pandith, S.A.; Vishwakarma, R.; Lattoo, S.K.
An inducible NADPH-cytochrome P450 reductase from Picrorhiza kurrooa - an imperative redox partner of cytochrome P450 enzymes
Funct. Integr. Genomics
14
381-399
2014
Picrorhiza kurrooa (G9JVI0)
Chen, X.; Zhang, Y.
Identification and characterization of NADPH-dependent cytochrome P450 reductase gene and cytochrome b5 gene from Plutella xylostella possible involvement in resistance to beta-cypermethrin
Gene
558
208-214
2015
Plutella xylostella
Spencer, A.L.; Bagai, I.; Becker, D.F.; Zuiderweg, E.R.; Ragsdale, S.W.
Protein/protein interactions in the mammalian heme degradation pathway heme oxygenase-2, cytochrome P450 reductase, and biliverdin reductase
J. Biol. Chem.
289
29836-29858
2014
Homo sapiens
Huang, R.; Zhang, M.; Rwere, F.; Waskell, L.; Ramamoorthy, A.
Kinetic and structural characterization of the interaction between the FMN binding domain of cytochrome P450 reductase and cytochrome c
J. Biol. Chem.
290
4843-4855
2015
Rattus norvegicus
Milhim, M.; Gerber, A.; Neunzig, J.; Hannemann, F.; Bernhardt, R.
A novel NADPH-dependent flavoprotein reductase from Bacillus megaterium acts as an efficient cytochrome P450 reductase
J. Biotechnol.
231
83-94
2016
Priestia megaterium, Priestia megaterium DSM319
Zhao, C.; Feng, X.; Tang, T.; Qiu, L.
Isolation and expression analysis of CYP9A11 and cytochrome P450 reductase gene in the beet armyworm (Lepidoptera Noctuidae)
J. Insect Sci.
15
122
2015
Spodoptera exigua (F1DI27), Spodoptera exigua
Suwanchaichinda, C.; Sun, D.; Brattsten, L.B.
Identification and analysis of NADPH-cytochrome P450 reductase in Aedes sollicitans (Diptera Culicidae)
J. Med. Entomol.
51
958-963
2014
Ochlerotatus sollicitans (B8Y644)
Hu, L.; Lv, J.F.; Zhuo, W.; Zhang, C.M.; Zhou, H.H.; Fan, L.
Effect of NADPH-cytochrome P450 reductase on all-trans-retinoic acid efficacy and cytochrome P450 26A1 expression in human myeloid leukaemia HL-60 cells
J. Pharm. Pharmacol.
68
1193-1202
2016
Homo sapiens
Galanie, S.; Smolke, C.
Optimization of yeast-based production of medicinal protoberberine alkaloids
Microb. Cell Fact.
14
144
2015
Arabidopsis thaliana (Q9SB48)
Zhao, C.; Tang, T.; Feng, X.; Qiu, L.
Cloning and characterisation of NADPH-dependent cytochrome P450 reductase gene in the cotton bollworm, Helicoverpa armigera
Pest Manag. Sci.
70
130-139
2014
Helicoverpa armigera (E0A3A7), Helicoverpa armigera
Sintupachee, S.; Promden, W.; Ngamrojanavanich, N.; Sitthithaworn, W.; De-Eknamkul, W.
Functional expression of a putative geraniol 8-hydroxylase by reconstitution of bacterially expressed plant CYP76F45 and NADPH-cytochrome P450 reductase CPR I from Croton stellatopilosus Ohba
Phytochemistry
118
204-215
2015
Croton stellatopilosus
Lee, G.Y.; Kim, H.M.; Ma, S.H.; Park, S.H.; Joung, Y.H.; Yun, C.H.
Heterologous expression and functional characterization of the NADPH-cytochrome P450 reductase from Capsicum annuum
Plant Physiol. Biochem.
82
116-122
2014
Capsicum annuum (A0A0N6XHR4), Capsicum annuum (B5LAU2)
Sintupachee, S.; Ngamrojanavanich, N.; Sitthithaworn, W.; De-Eknamkul, W.
Molecular cloning, bacterial expression and functional characterisation of cytochrome P450 monooxygenase, CYP97C27, and NADPH-cytochrome P450 reductase, CPR I, from Croton stellatopilosus Ohba
Plant Sci.
229
131-141
2014
Croton stellatopilosus (A0A0A8KYF2), Croton stellatopilosus
Qu, X.; Pu, X.; Chen, F.; Yang, Y.; Yang, L.; Zhang, G.; Luo, Y.
Molecular cloning, heterologous expression, and functional characterization of an NADPH-cytochrome P450 reductase gene from Camptotheca acuminata, a camptothecin-producing plant
PLoS ONE
10
e0135397
2015
Camptotheca acuminata (A0A0D5BVX3)
Tsai, F.M.; Chen, M.L.; Wang, L.K.; Lee, M.C.
H-rev107 regulates cytochrome P450 reductase activity and increases lipid accumulation
PLoS ONE
10
e0138586
2015
Mus musculus
Wang, K.; Peng, X.; Zuo, Y.; Li, Y.; Chen, M.
Molecular cloning, expression pattern and polymorphisms of NADPH-cytochrome P450 reductase in the bird cherry-oat aphid Rhopalosiphum padi (L.)
PLoS ONE
11
e0154633
2016
Rhopalosiphum padi (A0A172R1D8)
Gocek, E.; Marchwicka, A.; Bujko, K.; Marcinkowska, E.
NADPH-cytochrome P450 reductase is regulated by all-trans retinoic acid and by 1,25-dihydroxyvitamin D3 in human acute myeloid leukemia cells
PLoS ONE
9
e91752
2014
Homo sapiens
Etzerodt, T.; Wetterhorn, K.; Dionisio, G.; Rayment, I.
Functional characterization of a soluble NADPH-cytochrome P450 reductase from Fusarium graminearum
Protein Expr. Purif.
138
69-75
2017
Fusarium graminearum, Fusarium graminearum PH-1
Shi, L.; Zhang, J.; Shen, G.; Xu, Z.; Wei, P.; Zhang, Y.; Xu, Q.; He, L.
Silencing NADPH-cytochrome P450 reductase results in reduced acaricide resistance in Tetranychus cinnabarinus (Boisduval)
Sci. Rep.
5
15581
2015
Tetranychus cinnabarinus (A0A0K0PSZ5), Tetranychus cinnabarinus
Huang, Y.; Lu, X.P.; Wang, L.L.; Wei, D.; Feng, Z.J.; Zhang, Q.; Xiao, L.F.; Dou, W.; Wang, J.J.
Functional characterization of NADPH-cytochrome P450 reductase from Bactrocera dorsalis Possible involvement in susceptibility to malathion
Sci. Rep.
5
18394
2015
Bactrocera dorsalis (A0A034WP73), Bactrocera dorsalis
Dai, Y.; Zhen, J.; Zhang, X.; Zhong, Y.; Liu, S.; Sun, Z.; Guo, Y.; Wu, Q.
Analysis of the complex formation, interaction and electron transfer pathway between the open conformation of NADPH-cytochrome P450 reductase and aromatase
Steroids
101
116-124
2015
Rattus norvegicus (P00388)
Kuzu, M.; Ciftci, M.
Purification and characterization of NADPH-cytochrome P450 reductase from lake van fish liver microsomes and investigation of some chemical and metals effects on the enzyme activity
Turk. J. Chem.
39
149-158
2015
Alburnus tarichi
-
Davydov, R.M.; Jennings, G.; Hoffman, B.M.; Podust, L.M.
Short-lived neutral FMN and FAD semiquinones are transient intermediates in cryo-reduced yeast NADPH-cytochrome P450 reductase
Arch. Biochem. Biophys.
673
108080
2019
Saccharomyces cerevisiae (P16603), Saccharomyces cerevisiae ATCC 204508 (P16603)
Hubbard, P.A.; Xia, C.; Shen, A.L.; Kim, J.P.
Structural and kinetic investigations of the carboxy terminus of NADPH-cytochrome P450 oxidoreductase
Arch. Biochem. Biophys.
701
108792
2021
Homo sapiens (P16435)
Song, W.; Yan, S.; Li, Y.; Feng, S.; Zhang, J.J.; Li, J.R.
Functional characterization of squalene epoxidase and NADPH-cytochrome P450 reductase in Dioscorea zingiberensis
Biochem. Biophys. Res. Commun.
509
822-827
2019
Dioscorea zingiberensis
Xia, C.; Shen, A.L.; Duangkaew, P.; Kotewong, R.; Rongnoparut, P.; Feix, J.; Kim, J.P.
Structural and functional studies of the membrane-binding domain of NADPH-cytochrome P450 oxidoreductase
Biochemistry
58
2408-2418
2019
Homo sapiens (P16435)
Campelo, D.; Lautier, T.; Urban, P.; Esteves, F.; Bozonnet, S.; Truan, G.; Kranendonk, M.
The hinge segment of human NADPH-cytochrome P450 reductase in conformational switching The critical role of ionic strength
Front. Pharmacol.
8
755
2017
Homo sapiens (P16435)
Hussain, R.; Ahmed, M.; Khan, T.A.; Akhter, Y.
Augmentation of cytochrome P450 monooxygenase catalysis on its interaction with NADPH-cytochrome P450 reductase FMN domain from Trichoderma brevicompactum
Int. J. Biochem. Cell Biol.
103
74-80
2018
Trichoderma brevicompactum
Lin, H.; Wang, J.; Qi, M.; Guo, J.; Rong, Q.; Tang, J.; Wu, Y.; Ma, X.; Huang, L.
Molecular cloning and functional characterization of multiple NADPH-cytochrome P450 reductases from Andrographis paniculata
Int. J. Biol. Macromol.
102
208-217
2017
Andrographis paniculata (A0A1S6LKK3), Andrographis paniculata (A0A1S6LKK9), Andrographis paniculata
Nemeikaite-Ceniene, A.; Sarlauskas, J.; Miseviciene, L.; Maroziene, A.; Jonusiene, V.; Lesanavicius, M.; Cenas, N.
Aerobic cytotoxicity of aromatic N-oxides the role of NAD(P)H quinone oxidoreductase (NQO1)
Int. J. Mol. Sci.
21
8754
2020
Rattus norvegicus (P00388)
Barnaba, C.; Martinez, M.J.; Taylor, E.; Barden, A.O.; Brozik, J.A.
Single-protein tracking reveals that NADPH mediates the insertion of cytochrome P450 reductase into a biomimetic of the endoplasmic reticulum
J. Am. Chem. Soc.
139
5420-5430
2017
Homo sapiens
Tsou, C.Y.; Matsunaga, S.; Okada, S.
Molecular cloning and functional characterization of NADPH-dependent cytochrome P450 reductase from the green microalga Botryococcus braunii, B race
J. Biosci. Bioeng.
125
30-37
2018
Botryococcus braunii
Park, H.G.; Lim, Y.R.; Han, S.; Jeong, D.; Kim, D.
Enhanced purification of recombinant rat NADPH-P450 reductase by using a hexahistidine-tag
J. Microbiol. Biotechnol.
27
983-989
2017
Rattus norvegicus (P00388)
Chen, C.; Pi, W.; Zhang, Y.; Nie, C.X.; Liang, J.; Ma, X.; Wang, Y.; Ge, W.; Zhang, W.J.
Effect of a functional recombinant cytochrome P450 enzyme of Helicoverpa armigera on gossypol metabolism co-expressed with NADPH-cytochrome P450 reductase in Pichia pastoris
Pestic. Biochem. Physiol.
155
15-25
2019
Helicoverpa armigera (E0A3A7)
Adesanya, A.W.; Cardenas, A.; Lavine, M.D.; Walsh, D.B.; Lavine, L.C.; Zhu, F.
RNA interference of NADPH-cytochrome P450 reductase increases susceptibilities to multiple acaricides in Tetranychus urticae
Pestic. Biochem. Physiol.
165
104550
2020
Tetranychus urticae (T1KRF9)
html completed
