Information on EC 1.7.2.7 - hydrazine synthase

for references in articles please use BRENDA:EC1.7.2.7
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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.7.2.7
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RECOMMENDED NAME
GeneOntology No.
hydrazine synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
hydrazine + H2O + 3 ferricytochrome c = nitric oxide + ammonium + 3 ferrocytochrome c
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
ammonia oxidation II (anaerobic)
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Nitrogen metabolism
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Microbial metabolism in diverse environments
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SYSTEMATIC NAME
IUBMB Comments
hydrazine:ferricytochrome-c oxidoreductase
The enzyme, characterized from anaerobic ammonia oxidizers (anammox bacteria), is one of only two enzymes that are known to form an N-N bond (the other being EC 1.7.1.14, nitric oxide reductase [NAD(P)+, nitrous oxide-forming]). The enzyme from the bacterium Candidatus Kuenenia stuttgartiensis is heterotrimeric and contains multiple c-type cytochromes.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain KSU-1 is enriched from activated sludge collected from a wastewater treatment plant installed in the Kumamoto city, Japan
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Manually annotated by BRENDA team
strain KSU-1 is enriched from activated sludge collected from a wastewater treatment plant installed in the Kumamoto city, Japan
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
from the in situ microbial community in an oligotrophic, brackish environment of the Bothnian Sea sediment
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
hydrazine + H2O + ferricytochrome c
nitric oxide + ammonium + ferrocytochrome c
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
hydrazine + H2O + ferricytochrome c
nitric oxide + ammonium + ferrocytochrome c
show the reaction diagram
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
menaquinone
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predominant menaquinone is MK-7
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.33
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Ca. Jettenia caeni cells, pH not specified in the publication, 37°C
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
heterotrimer
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Q Sepharose chromatography and Superdex 200 gel filtration
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene hzsA, cloned from the in situ microbial community in an oligotrophic, brackish environment of the Bothnian Sea sediment, DNA and amino acid sequence determination and analysis, sequence comparisons. The sequence shows high similarity to uncultured Scalindua spp. originating from the marine sediments in Guyamas Basin (AGV76990)
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
a nitrite shock of 500 mg leads to a decrease in mRNA level; nitrite shocks of up to 400 mg lead to an increase in mRNA level
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
diagnostics