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Reference on EC 1.8.1.12 - trypanothione-disulfide reductase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cunningham, M.L.; Zvelebil, M.J.J.M.; Fairlamb, A.H.
Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals
Eur. J. Biochem.
221
285-295
1994
Crithidia fasciculata
Manually annotated by BRENDA team
Krauth-Siegel, R.L.; Jockers-Scheruebl, M.C.; Becker, K.; Schirmer, R.H.
NADPH-dependent disulphide reductases
Biochem. Soc. Trans.
17
315-317
1989
Crithidia fasciculata, Trypanosoma congolense, Trypanosoma cruzi
Manually annotated by BRENDA team
Stoll, V.S.; Simpson, S.J.; Krauth-Siegel, R.L.; Walsh, C.T.; Pai, E.F.
Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity
Biochemistry
36
6437-6447
1997
Homo sapiens, Trypanosoma cruzi
Manually annotated by BRENDA team
Montrichard, F.; Le Guen, F.; Laval-Martin, D.L.; Davioud-Charvet, E.
Evidence for the co-existence of glutathione reductase and trypanothione reductase in the non-trypanosomatid Euglenozoa: Euglena gracilis Z
FEBS Lett.
442
29-33
1999
Euglena gracilis, Euglena gracilis Z
Manually annotated by BRENDA team
Gallwitz, H.; Bonse, S.; Martinez-Cruz, A.; Schlichting, I.; Schumacher, K.; Krauth-Siegel, R.L.
Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies
J. Med. Chem.
42
364-372
1999
Trypanosoma cruzi
Manually annotated by BRENDA team
Taylor, M.C.; Chapman, C.J.; Kelly, J.M.; Fairlamb, A.H.; Miles, M.A.
Cloning by expression of a cDNA corresponding to Leishmania donovani trypanothione reductase
Biochem. Soc. Trans.
17
579-580
1989
Crithidia fasciculata, Leishmania aethiopica, Leishmania donovani, Trypanosoma brucei, Trypanosoma congolense, Trypanosoma cruzi
-
Manually annotated by BRENDA team
Sullivan, F.X.; Shames, S.L.; Walsh, C.T.
Expression of Trypanosoma congolense trypanothione reductase in Escherichia coli: overproduction, purification, and characterization
Biochemistry
28
4986-4992
1989
Crithidia fasciculata, Trypanosoma congolense, Trypanosoma cruzi
Manually annotated by BRENDA team
Fairlamb, A.H.; Henderson, G.B.; Cerami, A.
Trypanothione is the primary target for arsenical drugs against African trypanosomes
Proc. Natl. Acad. Sci. USA
86
2607-2611
1989
Crithidia fasciculata, Trypanosoma brucei
Manually annotated by BRENDA team
Jockers-Scheruebl, M.C.; Schirmer, R.H.; Krauth-Siegel, R.L.
Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds
Eur. J. Biochem.
180
267-272
1989
Trypanosoma cruzi
Manually annotated by BRENDA team
Henderson, G.B.; Ulrich, P.; Fairlamb, A.H.; Rosenberg, I.; Pereira, M.; Sela, M.; Cerami, A.
Subversive substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease
Proc. Natl. Acad. Sci. USA
85
5374-5378
1988
Crithidia fasciculata, Trypanosoma cruzi
Manually annotated by BRENDA team
Shames, S.L.; Kimmel, B.E.; Peoples, O.P.; Agabian, N.; Walsh, C.T.
Trypanothione reductase of Trypanosoma congolense: gene isolation, primary sequence determination, and comparison to glutathione reductase
Biochemistry
27
5014-5019
1988
Trypanosoma congolense
Manually annotated by BRENDA team
Henderson, G.B.; Fairlamb, A.H.; Ulrich, P.; Cerami, A.
Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata
Biochemistry
26
3023-3027
1987
Crithidia fasciculata
Manually annotated by BRENDA team
Krauth-Siegel, R.L.; Enders, B.; Henderson, G.B.; Fairlamb, A.H.; Schirmer, R.H.
Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme
Eur. J. Biochem.
164
123-128
1987
Trypanosoma cruzi
Manually annotated by BRENDA team
Shames, S.L.; Fairlamb, A.H.; Cerami, A.; Walsh, C.T.
Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases
Biochemistry
25
3519-3526
1986
Crithidia fasciculata
Manually annotated by BRENDA team
Garrard, E.A.; Borman, E.C.; Cook, B.N.; Pike, E.J.; Alberg, D.G.
Inhibition of trypanothione reductase by substrate analogues
Org. Lett.
2
3639-3642
2000
Trypanosoma cruzi
Manually annotated by BRENDA team
Blumenstiel, K.; Schoneck, R.; Yardley, V.; Croft, S.L.; Krauth-Siegel, R.L.
Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase
Biochem. Pharmacol.
58
1791-1799
1999
Trypanosoma congolense, Trypanosoma cruzi
Manually annotated by BRENDA team
Zheng, R.; Cenas, N.; Blanchard, J.S.
Catalytic and potentiometric characterization of E201D and E201Q mutants of Trypanosoma congolense trypanothione reductase
Biochemistry
34
12697-12703
1995
Trypanosoma congolense
Manually annotated by BRENDA team
Bond, C.S.; Zhang, Y.; Berriman, M.; Cunningham, M.L.; Fairlamb, A.H.; Hunter, W.N.
Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors
Structure
7
81-89
1999
Trypanosoma cruzi
Manually annotated by BRENDA team
Davioud-Charvet, E.; Becker, K.; Landry, V.; Gromer, S.; Loge, C.; Sergheraert, C.
Synthesis of 5,5'-dithiobis(2-nitrobenzamides) as alternative substrates for trypanothione reductase and thioredoxin reductase: a microtiter colorimetric assay for inhibitor screening
Anal. Biochem.
268
1-8
1999
Trypanosoma cruzi
Manually annotated by BRENDA team
Kelly, J.M.; Taylor, M.C.; Smith, K.; Hunter, K.J.; Fairlamb, A.H.
Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which over-express trypanothione reductase. Sensitivity towards agents that are thought to induce oxidative stress
Eur. J. Biochem.
218
29-37
1993
Leishmania donovani, Trypanosoma cruzi
Manually annotated by BRENDA team
Ponasik, J.A.; Strickland, C.; Faerman, C.; Savvides, S.; Karplus, P.A.; Ganem, B.
Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase
Biochem. J.
311
371-375
1995
Crithidia fasciculata
-
Manually annotated by BRENDA team
Cunningham, M.L.; Fairlamb, A.H.
Trypanothione reductase from Leishmania donovani. Purification, characterization and inhibition by trivalent antimonials
Eur. J. Biochem.
230
460-468
1995
Leishmania donovani
Manually annotated by BRENDA team
Borges, A.; Cunningham, M.L.; Tovar, J.; Fairlamb, A.H.
Site-directed mutagenesis of the redox-active cysteines of Trypanosoma cruzi trypanothione reductase
Eur. J. Biochem.
228
745-752
1995
Trypanosoma cruzi, Trypanosoma cruzi Silvio
Manually annotated by BRENDA team
El-Waer, A.F.; Smith, K.; McKie, J.H.; Benson, T.; Fairlamb, A.H.; Douglas, K.T.
The glutamyl binding site of trypanothione reductase from Crithidia fasciculata: enzyme kinetic properties of.gamma-glutamyl-modified substrate analogs
Biochim. Biophys. Acta
1203
93-98
1993
Crithidia fasciculata, Trypanosoma congolense
Manually annotated by BRENDA team
Salmon-Chemin, L.; Buisine, E.; Yardley, V.; Kohler, S.; Debreu, M.A.; Landry, V.; Sergheraert, C.; Croft, S.L.; Krauth-Siegel, R.L.; Davioud-Charvet, E.
2- And 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: Synthesis and correlation between redox cycling activities and in vitro cytotoxicity
J. Med. Chem.
44
548-565
2001
Leishmania donovani, Leishmania infantum, Trypanosoma brucei, Trypanosoma cruzi (P28593), Trypanosoma cruzi
Manually annotated by BRENDA team
Bonse, S.; Richards, J.M.; Ross, S.A.; Lowe, G.; Krauth-Siegel, R.L.
(2,2':6',2''-Terpyridine)platinum(II) complexes are irreversible inhibitors of Trypanosoma cruzi trypanothione reductase but not of human glutathione reductase
J. Med. Chem.
43
4812-4821
2000
Trypanosoma cruzi
Manually annotated by BRENDA team
Bonse, S.; Santelli-Rouvier, C.; Barbe, J.; Krauth-Siegel, R.L.
Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships
J. Med. Chem.
42
5448-5454
1999
Trypanosoma cruzi
Manually annotated by BRENDA team
Tovar, J.; Wilkinson, S.; Mottram, J.C.; Fairlamb, A.H.
Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus
Mol. Microbiol.
29
653-660
1998
Leishmania donovani
Manually annotated by BRENDA team
Fournet, A.; Inchausti, A.; Yaluff, G.; Royas De Arias, A.; Guinaudeau, H.; Bruneton, J.; Breidenbach, M.A.; Karplus, P.A.; Faerman, C.H.
Trypanocidal bisbenzylisoquinoline alkaloids are inhibitors of trypanothione reductase
J. Enzyme Inhib.
13
1-9
1998
Trypanosoma cruzi
Manually annotated by BRENDA team
Bonnet, B.; Soullez, D.; Davioud-Charvet, E.; Landry, V.; Horvath, D.; Sergheraert, C.
New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi trypanothione reductase
Bioorg. Med. Chem.
5
1249-1256
1997
Trypanosoma cruzi
Manually annotated by BRENDA team
Hamilton, C.J.; Saravanamuthu, A.; Fairlamb, A.H.; Eggleston, I.M.
Benzofuranyl 3,5-bis-polyamine derivatives as time-dependent inhibitors of trypanothione reductase
Bioorg. Med. Chem.
11
3683-3693
2003
Trypanosoma cruzi
Manually annotated by BRENDA team
Tamayo, E.M.; Iturbe, A.; Hernandez, E.; Hurtado, G.; de Lourdes Gutierrez, X.M.; Rosales, J.L.; Woolery, M.; Ondarza, R.N.
Trypanothione reductase from the human parasite Entamoeba histolytica: a new drug target
Biotechnol. Appl. Biochem.
41
105-115
2005
Entamoeba histolytica (Q8MZR8), Entamoeba histolytica
Manually annotated by BRENDA team
Saravanamuthu, A.; Vickers, T.J.; Bond, C.S.; Peterson, M.R.; Hunter, W.N.; Fairlamb, A.H.
Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design
J. Biol. Chem.
279
29493-29500
2004
no activity in Homo sapiens, Trypanosoma cruzi
Manually annotated by BRENDA team
Castro-Pinto, D.B.; Echevarria, A.; Genestra, M.S.; Cysne-Finkelstein, L.; Leon, L.L.
Trypanothione reductase activity is prominent in metacyclic promastigotes and axenic amastigotes of Leishmania amazonesis. Evaluation of its potential as a therapeutic target
J. Enzyme Inhib. Med. Chem.
19
57-63
2004
Leishmania amazonensis
Manually annotated by BRENDA team
Inhoff, O.; Richards, J.M.; Briet, J.W.; Lowe, G.; Krauth-Siegel, R.L.
Coupling of a competitive and an irreversible ligand generates mixed type inhibitors of Trypanosoma cruzi trypanothione reductase
J. Med. Chem.
45
4524-4530
2002
Trypanosoma cruzi
Manually annotated by BRENDA team
Mittal, M.K.; Misra, S.; Owais, M.; Goyal, N.
Expression, purification, and characterization of Leishmania donovani trypanothione reductase in Escherichia coli
Protein Expr. Purif.
40
279-286
2005
Leishmania donovani (Q95PT6), Leishmania donovani, Leishmania donovani Dd8 (Q95PT6)
Manually annotated by BRENDA team
Dixon, M.J.; Maurer, R.I.; Biggi, C.; Oyarzabal, J.; Essex, J.W.; Bradley, M.
Mechanism and structure-activity relationships of norspermidine-based peptidic inhibitors of trypanothione reductase
Bioorg. Med. Chem.
13
4513-4526
2005
Trypanosoma cruzi
Manually annotated by BRENDA team
Hamilton, C.J.; Saravanamuthu, A.; Poupat, C.; Fairlamb, A.H.; Eggleston, I.M.
Time-dependent inhibitors of trypanothione reductase: analogues of the spermidine alkaloid lunarine and related natural products
Bioorg. Med. Chem.
14
2266-2278
2006
Lunaria biennis
Manually annotated by BRENDA team
Holloway, G.A.; Baell, J.B.; Fairlamb, A.H.; Novello, P.M.; Parisot, J.P.; Richardson, J.; Watson, K.G.; Street, I.P.
Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening
Bioorg. Med. Chem. Lett.
17
1422-1427
2006
Trypanosoma brucei, Trypanosoma brucei rhodesiense
Manually annotated by BRENDA team
Romao, P.R.; Tovar, J.; Fonseca, S.G.; Moraes, R.H.; Cruz, A.K.; Hothersall, J.S.; Noronha-Dutra, A.A.; Ferreira, S.H.; Cunha, F.Q.
Glutathione and the redox control system trypanothione/trypanothione reductase are involved in the protection of Leishmania spp. against nitrosothiol-induced cytotoxicity
Braz. J. Med. Biol. Res.
39
355-363
2006
Leishmania amazonensis, Leishmania amazonensis MPRO/BR/72/M1841-LV-79, Leishmania braziliensis, Leishmania braziliensis MHOM/BR/75/M2904, Leishmania donovani, Leishmania donovani MHOM/ET/67/HU3, Leishmania major, Leishmania major LV-39
Manually annotated by BRENDA team
Ondarza, R.N.; Hurtado, G.; Tamayo, E.; Iturbe, A.; Hernandez, E.
Naegleria fowleri: a free-living highly pathogenic amoeba contains trypanothione/trypanothione reductase and glutathione/glutathione reductase systems
Exp. Parasitol.
114
141-146
2006
Naegleria fowleri
Manually annotated by BRENDA team
Ondarza, R.N.; Iturbe, A.; Hernandez, E.
The effects by neuroleptics, antimycotics and antibiotics on disulfide reducing enzymes from the human pathogens Acanthamoeba polyphaga and Naegleria fowleri
Exp. Parasitol.
115
41-47
2007
Naegleria fowleri
Manually annotated by BRENDA team
Meiering, S.; Inhoff, O.; Mies, J.; Vincek, A.; Garcia, G.; Kramer, B.; Dormeyer, M.; Krauth-Siegel, R.L.
Inhibitors of Trypanosoma cruzi trypanothione reductase revealed by virtual screening and parallel synthesis
J. Med. Chem.
48
4793-4802
2005
Trypanosoma cruzi
Manually annotated by BRENDA team
Lee, B.; Bauer, H.; Melchers, J.; Ruppert, T.; Rattray, L.; Yardley, V.; Davioud-Charvet, E.; Krauth-Siegel, R.L.
Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate
J. Med. Chem.
48
7400-7410
2005
Trypanosoma cruzi
Manually annotated by BRENDA team
Parveen, S.; Khan, M.O.; Austin, S.E.; Croft, S.L.; Yardley, V.; Rock, P.; Douglas, K.T.
Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide
J. Med. Chem.
48
8087-8097
2005
Trypanosoma cruzi
Manually annotated by BRENDA team
de Oliveira, R.B.; Vaz, A.B.; Alves, R.O.; Liarte, D.B.; Donnici, C.L.; Romanha, A.J.; Zani, C.L.
Arylfurans as potential Trypanosoma cruzi trypanothione reductase inhibitors
Mem. Inst. Oswaldo Cruz
101
169-173
2006
Trypanosoma cruzi
Manually annotated by BRENDA team
Castro-Pinto, D.B.; Genestra, M.; Menezes, G.B.; Waghabi, M.; Goncalves, A.; De Nigris Del Cistia, C.; SantAnna, C.M.; Leon, L.L.; Mendonca-Lima, L.
Cloning and expression of trypanothione reductase from a New World Leishmania species
Arch. Microbiol.
189
375-384
2008
Leishmania amazonensis (Q0GU43), Leishmania amazonensis
Manually annotated by BRENDA team
Blackie, M.A.; Saravanamuthu, A.; Fairlamb, A.H.; Chibale, K.
Inhibition of trypanothione reductase and glutathione reductase by ferrocenic 4-aminoquinoline ureas
ARKIVOC
2008
52-60
2008
Leishmania donovani, Trypanosoma brucei rhodesiense, Trypanosoma cruzi
-
Manually annotated by BRENDA team
Galarreta, B.C.; Sifuentes, R.; Carrillo, A.K.; Sanchez, L.; Amado, M.d.e.l.R.; Maruenda, H.
The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors
Bioorg. Med. Chem.
16
6689-6695
2008
Leishmania amazonensis, Trypanosoma cruzi
Manually annotated by BRENDA team
Martyn, D.C.; Jones, D.C.; Fairlamb, A.H.; Clardy, J.
High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity
Bioorg. Med. Chem. Lett.
17
1280-1283
2007
Trypanosoma brucei
Manually annotated by BRENDA team
Singh, B.K.; Sarkar, N.; Jagannadham, M.V.; Dubey, V.K.
Modeled structure of trypanothione reductase of Leishmania infantum
BMB Rep.
41
444-447
2008
Leishmania infantum
Manually annotated by BRENDA team
Stump, B.; Kaiser, M.; Brun, R.; Krauth-Siegel, R.L.; Diederich, F.
Betraying the parasites redox system: diaryl sulfide-based inhibitors of trypanothione reductase: subversive substrates and antitrypanosomal properties
ChemMedChem
2
1708-1712
2007
Trypanosoma brucei rhodesiense
Manually annotated by BRENDA team
Cota, B.B.; Rosa, L.H.; Caligiorne, R.B.; Rabello, A.L.; Almeida Alves, T.M.; Rosa, C.A.; Zani, C.L.
Altenusin, a biphenyl isolated from the endophytic fungus Alternaria sp., inhibits trypanothione reductase from Trypanosoma cruzi
FEMS Microbiol. Lett.
285
177-182
2008
Leishmania amazonensis, Trypanosoma cruzi
Manually annotated by BRENDA team
Castro-Pinto, D.B.; Lima, E.L.; Cunha, A.S.; Genestra, M.; De Leo, R.M.; Monteiro, F.; Leon, L.L.
Leishmania amazonensis trypanothione reductase: evaluation of the effect of glutathione analogs on parasite growth, infectivity and enzyme activity
J. Enzyme Inhib. Med. Chem.
22
71-75
2007
Leishmania amazonensis
Manually annotated by BRENDA team
Czechowicz, J.A.; Wilhelm, A.K.; Spalding, M.D.; Larson, A.M.; Engel, L.K.; Alberg, D.G.
The synthesis and inhibitory activity of dethiotrypanothione and analogues against trypanothione reductase
J. Org. Chem.
72
3689-3693
2007
Trypanosoma cruzi
Manually annotated by BRENDA team
Cota, B.B.; Rosa, L.H.; Fagundes, E.M.; Martins-Filho, O.A.; Correa-Oliveira, R.; Romanha, A.J.; Rosa, C.A.; Zani, C.L.
A potent trypanocidal component from the fungus Lentinus strigosus inhibits trypanothione reductase and modulates PBMC proliferation
Mem. Inst. Oswaldo Cruz
103
263-270
2008
Trypanosoma cruzi
Manually annotated by BRENDA team
Iribarne, F.; Gonzalez, M.; Cerecetto, H.; Aguilera, S.; Tapia, O.; Paulino, M.
Interaction energies of nitrofurans with trypanothione reductase and glutathione reductase studied by molecular docking
Theochem
818
7-22
2007
Trypanosoma cruzi
-
Manually annotated by BRENDA team
Rai, S.; Dwivedi, U.N.; Goyal, N.
Leishmania donovani trypanothione reductase: role of urea and guanidine hydrochloride in modulation of functional and structural properties
Biochim. Biophys. Acta
1794
1474-1484
2009
Leishmania donovani
Manually annotated by BRENDA team
Cavalli, A.; Lizzi, F.; Bongarzone, S.; Brun, R.; Luise Krauth-Siegel, R.; Bolognesi, M.L.
Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase
Bioorg. Med. Chem. Lett.
19
3031-3035
2009
Trypanosoma cruzi
Manually annotated by BRENDA team
Porcal, W.; Hernandez, P.; Boiani, L.; Boiani, M.; Ferreira, A.; Chidichimo, A.; Cazzulo, J.J.; Olea-Azar, C.; Gonzalez, M.; Cerecetto, H.
New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle
Bioorg. Med. Chem.
16
6995-7004
2008
Trypanosoma cruzi
Manually annotated by BRENDA team
Stump, B.; Eberle, C.; Schweizer, W.; Kaiser, M.; Brun, R.; Krauth-Siegel, R.; Lentz, D.; Diederich, F.
Pentafluorosulfanyl as a novel building block for enzyme inhibitors: Trypanothione reductase inhibition and antiprotozoal activities of diarylamines
ChemBioChem
10
79-83
2009
Trypanosoma cruzi (P28593)
Manually annotated by BRENDA team
Richardson, J.L.; Nett, I.R.; Jones, D.C.; Abdille, M.H.; Gilbert, I.H.; Fairlamb, A.H.
Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis
ChemMedChem
4
1333-1340
2009
Trypanosoma brucei
Manually annotated by BRENDA team
Patterson, S.; Jones, D.C.; Shanks, E.J.; Frearson, J.A.; Gilbert, I.H.; Wyatt, P.G.; Fairlamb, A.H.
Synthesis and evaluation of 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase
ChemMedChem
4
1341-1353
2009
Trypanosoma brucei, Trypanosoma brucei BSF 427
Manually annotated by BRENDA team
Eberle, C.; Burkhard, J.A.; Stump, B.; Kaiser, M.; Brun, R.; Krauth-Siegel, R.L.; Diederich, F.
Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on mepacrine-conjugated diaryl sulfide scaffolds
ChemMedChem
4
2034-2044
2009
Plasmodium falciparum, Trypanosoma brucei rhodesiense, Trypanosoma cruzi (P28593), Trypanosoma cruzi, Trypanosoma cruzi Tulahuen C4 (P28593), Trypanosoma brucei rhodesiense STIB900
Manually annotated by BRENDA team
Perez-Pineiro, R.; Burgos, A.; Jones, D.C.; Andrew, L.C.; Rodriguez, H.; Suarez, M.; Fairlamb, A.H.; Wishart, D.S.
Development of a novel virtual screening cascade protocol to identify potential trypanothione reductase inhibitors
J. Med. Chem.
52
1670-1680
2009
Trypanosoma cruzi (P28593), Trypanosoma cruzi, Trypanosoma brucei (P39051), Trypanosoma brucei
Manually annotated by BRENDA team
da Rocha Pita, S.S.; Cirino, J.J.; de Alencastro, R.B.; Castro, H.C.; Rodrigues, C.R.; Albuquerque, M.G.
Molecular docking of a series of peptidomimetics in the trypanothione binding site of T. cruzi trypanothione reductase
J. Mol. Graph. Model.
28
330-335
2009
Trypanosoma cruzi (P28593), Trypanosoma cruzi
Manually annotated by BRENDA team
Iribarne, F.; Paulino, M.; Aguilera, S.; Tapia, O.
Assaying phenothiazine derivatives as trypanothione reductase and glutathione reductase inhibitors by theoretical docking and Molecular Dynamics studies
J. Mol. Graph. Model.
28
371-381
2009
Trypanosoma cruzi (P28593), Trypanosoma cruzi
Manually annotated by BRENDA team
Jones, D.C.; Ariza, A.; Chow, W.H.; Oza, S.L.; Fairlamb, A.H.
Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi
Mol. Biochem. Parasitol.
169
12-19
2010
Trypanosoma brucei (P39051), Trypanosoma brucei
Manually annotated by BRENDA team
Stump, B.; Eberle, C.; Kaiser, M.; Brun, R.; Krauth-Siegel, R.L.; Diederich, F.
Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities
Org. Biomol. Chem.
6
3935-3947
2008
Plasmodium falciparum, Trypanosoma brucei rhodesiense, Trypanosoma brucei rhodesiense STIB900
Manually annotated by BRENDA team
Baiocco, P.; Franceschini, S.; Ilari, A.; Colotti, G.
Trypanothione reductase from Leishmania infantum: cloning, expression, purification, crystallization and preliminary X-ray data analysis
Protein Pept. Lett.
16
196-200
2009
Leishmania infantum
Manually annotated by BRENDA team
Holloway, G.A.; Charman, W.N.; Fairlamb, A.H.; Brun, R.; Kaiser, M.; Kostewicz, E.; Novello, P.M.; Parisot, J.P.; Richardson, J.; Street, I.P.; Watson, K.G.; Baell, J.B.
Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity
Antimicrob. Agents Chemother.
53
2824-2833
2009
Trypanosoma cruzi, Trypanosoma cruzi Silvio X10/1
Manually annotated by BRENDA team
Spinks, D.; Shanks, E.J.; Cleghorn, L.A.; McElroy, S.; Jones, D.; James, D.; Fairlamb, A.H.; Frearson, J.A.; Wyatt, P.G.; Gilbert, I.H.
Investigation of trypanothione reductase as a drug target in Trypanosoma brucei
ChemMedChem
4
2060-2069
2009
Trypanosoma brucei
Manually annotated by BRENDA team
Walton, J.G.; Jones, D.C.; Kiuru, P.; Durie, A.J.; Westwood, N.J.; Fairlamb, A.H.
Synthesis and evaluation of indatraline-based inhibitors for trypanothione reductase
ChemMedChem
6
321-328
2011
Trypanosoma brucei
Manually annotated by BRENDA team
Eberle, C.; Lauber, B.S.; Fankhauser, D.; Kaiser, M.; Brun, R.; Krauth-Siegel, R.L.; Diederich, F.
Improved inhibitors of trypanothione reductase by combination of motifs: synthesis, inhibitory potency, binding mode, and antiprotozoal activities
ChemMedChem
6
292-301
2011
Leishmania donovani, Plasmodium falciparum, Trypanosoma brucei rhodesiense, Trypanosoma cruzi (P28593)
Manually annotated by BRENDA team
Venkatesan, S.K.; Shukla, A.K.; Dubey, V.K.
Molecular docking studies of selected tricyclic and quinone derivatives on trypanothione reductase of Leishmania infantum
J. Comput. Chem.
31
2463-2475
2010
Leishmania infantum (A4HSF7), Leishmania infantum
Manually annotated by BRENDA team
Shukla, A.K.; Patra, S.; Dubey, V.K.
Biophysical and folding parameters of trypanothione reductase from Leishmania infantum
Appl. Biochem. Biotechnol.
165
13-23
2011
Leishmania infantum
Manually annotated by BRENDA team
Rodrigues, R.F.; Castro-Pinto, D.; Echevarria, A.; dos Reis, C.M.; Del Cistia, C.N.; SantAnna, C.M.; Teixeira, F.; Castro, H.; Canto-Cavalheiro, M.; Leon, L.L.; Tomas, A.
Investigation of trypanothione reductase inhibitory activity by 1,3,4-thiadiazolium-2-aminide derivatives and molecular docking studies
Bioorg. Med. Chem.
20
1760-1766
2012
Leishmania amazonensis, Leishmania braziliensis, Leishmania infantum, Trypanosoma cruzi, Trypanosoma cruzi Y, Leishmania amazonensis MHOM/BR/LTB0016, Leishmania infantum MHOM/MA67ITMAP263, Leishmania braziliensis MCAN/BR/98/R619
Manually annotated by BRENDA team
Toro, M.A.; Sanchez-Murcia, P.A.; Moreno, D.; Ruiz-Santaquiteria, M.; Alzate, J.F.; Negri, A.; Camarasa, M.J.; Gago, F.; Velazquez, S.; Jimenez-Ruiz, A.
Probing the dimerization interface of Leishmania infantum trypanothione reductase with site-directed mutagenesis and short peptides
ChemBioChem
14
1212-1217
2013
Leishmania infantum (A4HSF7), Leishmania infantum
Manually annotated by BRENDA team
Baiocco, P.; Poce, G.; Alfonso, S.; Cocozza, M.; Porretta, G.C.; Colotti, G.; Biava, M.; Moraca, F.; Botta, M.; Yardley, V.; Fiorillo, A.; Lantella, A.; Malatesta, F.; Ilari, A.
Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography
ChemMedChem
8
1175-1183
2013
Leishmania infantum (A4HSF7), Leishmania infantum
Manually annotated by BRENDA team
Colotti, G.; Ilari, A.; Fiorillo, A.; Baiocco, P.; Cinellu, M.A.; Maiore, L.; Scaletti, F.; Gabbiani, C.; Messori, L.
Metal-based compounds as prospective antileishmanial agents: inhibition of trypanothione reductase by selected gold complexes
ChemMedChem
8
1634-1637
2013
Leishmania infantum
Manually annotated by BRENDA team
Lazarin-Bidoia, D.; Desoti, V.C.; Ueda-Nakamura, T.; Dias Filho, B.P.; Nakamura, C.V.; Silva, S.O.
Further evidence of the trypanocidal action of eupomatenoid-5: confirmation of involvement of reactive oxygen species and mitochondria owing to a reduction in trypanothione reductase activity
Free Radic. Biol. Med.
60
17-28
2013
Trypanosoma cruzi
Manually annotated by BRENDA team
Mutlu, O.
Molecular modeling, structural analysis and identification of ligand binding sites of trypanothione reductase from Leishmania mexicana
J. Vector Borne Dis.
50
38-44
2013
Leishmania mexicana (E9AKE1), Leishmania mexicana, Leishmania mexicana MHOM/GT/2001/U1103 (E9AKE1)
Manually annotated by BRENDA team
Arias, D.G.; Herrera, F.E.; Garay, A.S.; Rodrigues, D.; Forastieri, P.S.; Luna, L.E.; Buergi, M.D.; Prieto, C.; Iglesias, A.A.; Cravero, R.M.; Guerrero, S.A.
Rational design of nitrofuran derivatives Synthesis and valuation as inhibitors of Trypanosoma cruzi trypanothione reductase
Eur. J. Med. Chem.
125
1088-1097
2017
Trypanosoma cruzi (V5AJG2), Trypanosoma cruzi, Trypanosoma cruzi Dm28c (V5AJG2)
Manually annotated by BRENDA team
Ferreira, L.G.; Andricopulo, A.D.
Inhibitors of Trypanosoma brucei trypanothione reductase comparative molecular field analysis modeling and structural basis for selective inhibition
Future Med. Chem.
5
1753-1762
2013
Trypanosoma brucei brucei (Q389T8), Trypanosoma brucei brucei 927/4 GUTat10.1 (Q389T8)
Manually annotated by BRENDA team
Pandey, R.K.; Sharma, D.; Bhatt, T.K.; Sundar, S.; Prajapati, V.K.
Developing imidazole analogues as potential inhibitor for Leishmania donovani trypanothione reductase virtual screening, molecular docking, dynamics and ADMET approach
J. Biomol. Struct. Dyn.
33
2541-2553
2015
Leishmania donovani
Manually annotated by BRENDA team
Pandey, R.K.; Kumbhar, B.V.; Srivastava, S.; Malik, R.; Sundar, S.; Kunwar, A.; Prajapati, V.K.
Febrifugine analogues as Leishmania donovani trypanothione reductase inhibitors binding energy analysis assisted by molecular docking, ADMET and molecular dynamics simulation
J. Biomol. Struct. Dyn.
35
141-158
2017
Leishmania donovani
Manually annotated by BRENDA team
Saccoliti, F.; Angiulli, G.; Pupo, G.; Pescatori, L.; Madia, V.N.; Messore, A.; Colotti, G.; Fiorillo, A.; Scipione, L.; Gramiccia, M.; Di Muccio, T.; Di Santo, R.; Costi, R.; Ilari, A.
Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives
J. Enzyme Inhib. Med. Chem.
32
304-310
2017
Leishmania infantum (A4HSF7), Leishmania infantum
Manually annotated by BRENDA team
Chacon-Vargas, K.F.; Nogueda-Torres, B.; Sanchez-Torres, L.E.; Suarez-Contreras, E.; Villalobos-Rocha, J.C.; Torres-Martinez, Y.; Lara-Ramirez, E.E.; Fiorani, G.; Krauth-Siegel, R.L.; Bolognesi, M.L.; Monge, A.; Rivera, G.
Trypanocidal activity of quinoxaline 1,4 di-N-oxide derivatives as trypanothione reductase inhibitors
Molecules
22
220
2017
Trypanosoma cruzi (P28593)
Manually annotated by BRENDA team
Argueelles, A.J.; Cordell, G.A.; Maruenda, H.
Molecular docking and binding mode analysis of plant alkaloids as in vitro and in silico inhibitors of trypanothione reductase from Trypanosoma cruzi
Nat. Prod. Commun.
11
57-62
2016
Trypanosoma cruzi
Manually annotated by BRENDA team
Beig, M.; Oellien, F.; Garoff, L.; Noack, S.; Krauth-Siegel, R.L.; Selzer, P.M.
Trypanothione reductase a target protein for a combined in vitro and in silico screening approach
PLoS Negl. Trop. Dis.
9
e0003773
2015
Trypanosoma brucei brucei
Manually annotated by BRENDA team
Revuelto, A.; Ruiz-Santaquiteria, M.; de Lucio, H.; Gamo, A.; Carriles, A.A.; Gutierrez, K.J.; Sanchez-Murcia, P.A.; Hermoso, J.A.; Gago, F.; Camarasa, M.J.; Jimenez-Ruiz, A.; Velazquez, S.
Pyrrolopyrimidine vs imidazole-phenyl-thiazole scaffolds in nonpeptidic dimerization inhibitors of Leishmania infantum trypanothione reductase
ACS Infect. Dis.
5
873-891
2019
Leishmania infantum (A4HSF7), Leishmania infantum
Manually annotated by BRENDA team
Etxebeste-Mitxeltorena, M.; Plano, D.; Espuelas, S.; Moreno, E.; Aydillo, C.; Jimenez-Ruiz, A.; Soriano, J.C.G.; Sanmartin, C.
New amides containing selenium as potent Leishmanicidal agents targeting trypanothione reductase
Antimicrob. Agents Chemother.
65
e00524-20
2020
Leishmania infantum (A4HSF7), Leishmania infantum
Manually annotated by BRENDA team
Tiwari, N.; Tanwar, N.; Munde, M.
Molecular insights into trypanothione reductase-inhibitor interaction A structure-based review
Arch. Pharm.
351
e1700373
2018
Leishmania infantum (A4HSF7)
Manually annotated by BRENDA team
De Gasparo, R.; Brodbeck-Persch, E.; Bryson, S.; Hentzen, N.B.; Kaiser, M.; Pai, E.F.; Krauth-Siegel, R.L.; Diederich, F.
Biological evaluation and X-ray co-crystal structures of cyclohexylpyrrolidine ligands for trypanothione reductase, an enzyme from the redox metabolism of Trypanosoma
ChemMedChem
13
957-967
2018
Trypanosoma cruzi, Trypanosoma brucei brucei (Q389T8), Trypanosoma brucei brucei 927/4 GUTat10.1 (Q389T8)
Manually annotated by BRENDA team
Ghosh, A.K.; Saini, S.; Das, S.; Mandal, A.; Sardar, A.H.; Ansari, M.Y.; Abhishek, K.; Kumar, A.; Singh, R.; Verma, S.; Equbal, A.; Ali, V.; Das, P.
Glucose-6-phosphate dehydrogenase and trypanothione reductase interaction protects Leishmania donovani from metalloid mediated oxidative stress
Free Radic. Biol. Med.
106
10-23
2017
Leishmania donovani (P39050), Leishmania donovani
Manually annotated by BRENDA team
da Silva, A.D.; Dos Santos, J.A.; Machado, P.A.; Alves, L.A.; Laque, L.C.; de Souza, V.C.; Coimbra, E.S.; Capriles, P.V.S.Z.
Insights about resveratrol analogs against trypanothione reductase of Leishmania braziliensis Molecular modeling, computational docking and in vitro antileishmanial studies
J. Biomol. Struct. Dyn.
37
2960-2969
2019
Leishmania braziliensis
Manually annotated by BRENDA team
Vazquez, K.; Paulino, M.; Salas, C.O.; Zarate-Ramos, J.J.; Vera, B.; Rivera, G.
Trypanothione reductase a target for the development of anti-Trypanosoma cruzi drugs
Mini Rev. Med. Chem.
17
939-946
2017
Trypanosoma cruzi (P28593), Trypanosoma cruzi
Manually annotated by BRENDA team
Rodriguez-Becerra, J.; Caceres-Jensen, L.; Hernandez-Ramos, J.; Barrientos, L.
Identification of potential trypanothione reductase inhibitors among commercially available beta-carboline derivatives using chemical space, lead-like and drug-like filters, pharmacophore models and molecular docking
Mol. Divers.
21
697-711
2017
Trypanosoma cruzi (P28593), Trypanosoma cruzi
Manually annotated by BRENDA team
Lenz, M.; Krauth-Siegel, R.L.; Schmidt, T.J.
Natural sesquiterpene lactones of the 4,15-iso-atriplicolide type are inhibitors of trypanothione reductase
Molecules
24
3737
2019
Trypanosoma brucei rhodesiense, Trypanosoma cruzi (P28593)
Manually annotated by BRENDA team
Maamri, S.; Benarous, K.; Yousfi, M.
Identification of 3-methoxycarpachromene and masticadienonic acid as new target inhibitors against trypanothione reductase from Leishmania infantum using molecular docking and ADMET prediction
Molecules
26
3335
2021
Leishmania infantum (A4HSF7), Leishmania infantum
Manually annotated by BRENDA team
Coro-Bermello, J.; Lopez-Rodriguez, E.; Alfonso-Ramos, J.; Alonso, D.; Ojeda-Carralero, G.; Prado, G.; Moreno-Castillo, E.
Identification of novel thiadiazin derivatives as potentially selective inhibitors towards trypanothione reductase from Trypanosoma cruzi by molecular docking using the numerical index poses ratio Pr and the binding mode analysis
SN Appl. Sci.
3
376
2021
Trypanosoma cruzi (P28593)
-
Manually annotated by BRENDA team