Disease on EC 1.8.4.11 - peptide-methionine (S)-S-oxide reductase

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DISEASE
TITLE OF PUBLICATION
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Alzheimer Disease
Effect of Punicalagin and Resveratrol on Methionine Sulfoxide Reductase: A Possible Protective Contribution against Alzheimer's Disease.
Methionine sulfoxide reductase A affects ?-amyloid solubility and mitochondrial function in a mouse model of Alzheimer's disease.
Arthritis, Rheumatoid
Association of the methionine sulfoxide reductase A rs10903323 gene polymorphism with cardiovascular disease in patients with rheumatoid arthritis.
MSRA polymorphism is associated with the risk of rheumatoid arthritis in a Chinese population.
Atherosclerosis
Hepatic overexpression of methionine sulfoxide reductase A reduces atherosclerosis in apolipoprotein E-deficient mice.
Breast Neoplasms
Methionine sulfoxide reductase A down-regulation in human breast cancer cells results in a more aggressive phenotype.
Cardiovascular Diseases
Association of the methionine sulfoxide reductase A rs10903323 gene polymorphism with cardiovascular disease in patients with rheumatoid arthritis.
Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription.
Cataract
Methionine sulfoxide reductase A (MsrA) restores alpha-crystallin chaperone activity lost upon methionine oxidation.
Silencing of the methionine sulfoxide reductase A gene results in loss of mitochondrial membrane potential and increased ROS production in human lens cells.
Coronary Artery Disease
Methionine sulfoxide reductase A rs10903323 G/A polymorphism is associated with increased risk of coronary artery disease in a Chinese population.
Diphtheria
Corynebacterium diphtheriae methionine sulfoxide reductase A exploits a unique mycothiol redox relay mechanism.
Hearing Loss
Methionine Sulfoxide Reductase A Knockout Mice Show Progressive Hearing Loss and Sensitivity to Acoustic Trauma.
Hearing Loss, Noise-Induced
Methionine Sulfoxide Reductase A Knockout Mice Show Progressive Hearing Loss and Sensitivity to Acoustic Trauma.
Heart Rupture
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.
Infections
Vibrio cholerae ensures function of host proteins required for virulence through consumption of luminal methionine sulfoxide.
Insulin Resistance
Methionine sulfoxide reductase A affects insulin resistance by protecting insulin receptor function.
Methionine sulfoxide reductase B1 deficiency does not increase high-fat diet-induced insulin resistance in mice.
MsrA Overexpression Targeted to the Mitochondria, but Not Cytosol, Preserves Insulin Sensitivity in Diet-Induced Obese Mice.
Leukemia
Overexpression of mitochondrial methionine sulfoxide reductase B2 protects leukemia cells from oxidative stress-induced cell death and protein damage.
Liposarcoma
miR-193b-regulated signaling networks serve as tumor suppressors in liposarcoma and promote adipogenesis in adipose-derived stem cells.
Mycoses
Comparison of pathogen-induced expression and efficacy of two amphibian antimicrobial peptides, MsrA2 and temporin A, for engineering wide-spectrum disease resistance in tobacco.
Myocardial Infarction
A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation.
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.
nadph dehydrogenase (quinone) deficiency
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.
Neoplasm Metastasis
Identification of MSRA gene on chromosome 8p as a candidate metastasis suppressor for human hepatitis B virus-positive hepatocellular carcinoma.
Neoplasms
Methionine sulfoxide reductase A down-regulation in human breast cancer cells results in a more aggressive phenotype.
Neuroblastoma
Oxidation of methionine 35 reduces toxicity of the amyloid beta-peptide(1-42) in neuroblastoma cells (IMR-32) via enzyme methionine sulfoxide reductase A expression and function.
Resveratrol preconditioning increases methionine sulfoxide reductases A expression and enhances resistance of human neuroblastoma cells to neurotoxins.
Neurodegenerative Diseases
Elevated levels of brain-pathologies associated with neurodegenerative diseases in the methionine sulfoxide reductase A knockout mouse.
Obesity
Association study of common polymorphisms in MSRA, TFAP2B, MC4R, NRXN3, PPARGC1A, TMEM18, SEC16B, HOXB5 and OLFM4 genes with obesity-related traits among Portuguese children.
Methionine sulfoxide reductase A affects insulin resistance by protecting insulin receptor function.
Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population.
Obesity, Abdominal
Implications of central obesity-related variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on quantitative metabolic traits in adult Danes.
peptide-methionine (s)-s-oxide reductase deficiency
Methionine sulfoxide reductase A deficiency exacerbates acute liver injury induced by acetaminophen.
Methionine Sulfoxide Reductase A Deficiency Exacerbates Cisplatin-Induced Nephrotoxicity via Increased Mitochondrial Damage and Renal Cell Death.
Methionine sulfoxide reductase A deficiency exacerbates progression of kidney fibrosis induced by unilateral ureteral obstruction.
Pulmonary Fibrosis
Autoantibody against one of the antioxidant repair enzymes, methionine sulfoxide reductase A, in systemic sclerosis: association with pulmonary fibrosis and vascular damage.
Reperfusion Injury
Myristoylated Methionine Sulfoxide Reductase A Protects the Heart from Ischemia-Reperfusion Injury.
Scleroderma, Systemic
Autoantibody against one of the antioxidant repair enzymes, methionine sulfoxide reductase A, in systemic sclerosis: association with pulmonary fibrosis and vascular damage.
Shock, Septic
Methionine sulfoxide reductase A protects against lipopolysaccharide-induced septic shock via negative regulation of the proinflammatory responses.
Tuberculosis
A natural carbohydrate substrate for Mycobacterium tuberculosis methionine sulfoxide reductase A.
Structure of Mycobacterium tuberculosis methionine sulfoxide reductase A in complex with protein-bound methionine.
Ureteral Obstruction
Methionine sulfoxide reductase A deficiency exacerbates progression of kidney fibrosis induced by unilateral ureteral obstruction.
Vascular Diseases
Deletion of Methionine Sulfoxide Reductase A Does Not Affect Atherothrombosis but Promotes Neointimal Hyperplasia and Extracellular Signal-Regulated Kinase 1/2 Signaling.
Vitiligo
Decreased methionine sulphoxide reductase A expression renders melanocytes more sensitive to oxidative stress: a possible cause for melanocyte loss in vitiligo.
Methionine sulfoxide reductases A and B are deactivated by hydrogen peroxide (H2O2) in the epidermis of patients with vitiligo.