Reference on EC 1.8.4.11 - peptide-methionine (S)-S-oxide reductase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Grimaud, R.; Ezraty, B.; Mitchell, J.K.; Lafitte, D.; Briand, C.; Derrick, P.J.; Barras, F.
Repair of oxidized proteins: identification of a new methionine sulfoxide reductase
J. Biol. Chem.
276
48915-48920
2001
Escherichia coli
Manually annotated by BRENDA team
Moskovitz, J.; Bar-Noy, S.; Williams, W.M.; Requena, J.; Berlett, B.S.; Stadtman, E.R.
Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals
Proc. Natl. Acad. Sci. USA
98
12920-12925
2001
Mus musculus
Manually annotated by BRENDA team
Brot, N.; Weissbach, L.; Werth, J.; Weissbach, H.
Enzymatic reduction of protein-bound methionine sulfoxide
Proc. Natl. Acad. Sci. USA
78
2155-2158
1981
Escherichia coli, Escherichia coli Z19
Manually annotated by BRENDA team
Wizemann, T.M.; Moskovitz, J.; Pearce, B.J.; Cundell, D.; Arvidson, C.G.; So, M.; Weissbach, H.; Brot, N.; Masure, H.R.
Peptide methionine-sulfoxide reductase contributes to the maintenance of adhesions in three major pathogens
Proc. Natl. Acad. Sci. USA
93
7985-7990
1996
Escherichia coli, Neisseria gonorrhoeae, Neisseria gonorrhoeae MS11A, Streptococcus pneumoniae, Streptococcus pneumoniae R6x
Manually annotated by BRENDA team
Moskovitz, J.; Poston, J.M.; Berlett, B.S.; Nosworthy, N.J.; Szczepanowski, R.; Stadtman, E.R.
Identification and characterization of a putative active site for peptide methionine sulfoxide reductase (MsrA) and its substrate stereospecificity
J. Biol. Chem.
275
14167-14172
2000
Escherichia coli, Saccharomyces cerevisiae
Manually annotated by BRENDA team
Lowther, W.T.; Brot, N.; Weissbach, H.; Honek, J.F.; Matthews, B.W.
Thiol-disulfide exchange is involved in the catalytic mechanism of peptide methionine sulfoxide reductase
Proc. Natl. Acad. Sci. USA
97
6463-6468
2000
Bos taurus
Manually annotated by BRENDA team
St.John, G.; Brot, N.; Ruan, J.; Erdjument-Bromage, H.; Tempst, P.; Weissbach, H.; Nathan, C.
Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates
Proc. Natl. Acad. Sci. USA
98
9901-9906
2001
Escherichia coli, Mycobacterium tuberculosis
Manually annotated by BRENDA team
Dhandayuthapani, S.; Blaylock, M.W.; Bebear, C.M.; Rasmussen, W.G.; Baseman, J.B.
Peptide methionine sulfoxide reductase (MsrA) is a virulence determinant in Mycoplasma genitalium
J. Bacteriol.
183
5645-5650
2001
Mycoplasma genitalium
Manually annotated by BRENDA team
Ruan, H.; Tang, X.D.; Chen, M.L.; Joiner, M.A.; Sun, G.; Brot, N.; Weissbach, H.; Heinemann, S.H.; Iverson, L.; Wu, C.F.; Hoshi, T.
High-quality life extension by the enzyme peptide methionine sulfoxide reductase
Proc. Natl. Acad. Sci. USA
99
2748-2753
2002
Bos taurus
Manually annotated by BRENDA team
Olry, A.; Boschi-Muller, S.; Marraud, M.; Sanglier-Cianferani, S.; Van Dorsselear, A.; Branlant, G.
Characterization of the methionine sulfoxide reductase activities of PILB, a probable virulence factor from Neisseria meningitidis
J. Biol. Chem.
277
12016-12022
2002
Neisseria meningitidis
Manually annotated by BRENDA team
Hansel, A.; Kuschel, L.; Hehl, S.; Lemke, C.; Agricola, H.J.; Hoshi, T.; Heinemann, S.H.
Mitochondrial targeting of the human peptide methionine sulfoxide reductase (MSRA), an enzyme involved in the repair of oxidized proteins
FASEB J.
16
911-913
2002
Homo sapiens (Q9UJ68)
Manually annotated by BRENDA team
Weissbach, H.; Etienne, F.; Hoshi, T.; Heinemann, S.H.; Lowther, W.T.; Matthews, B.; St John, G.; Nathan, C.; Brot, N.
Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function
Arch. Biochem. Biophys.
397
172-178
2002
Escherichia coli, Streptococcus pneumoniae
Manually annotated by BRENDA team
Lee, B.C.; Lee, Y.K.; Lee, H.J.; Stadtman, E.R.; Lee, K.H.; Chung, N.
Cloning and characterization of antioxidant enzyme methionine sulfoxide-S-reductase from Caenorhabditis elegans
Arch. Biochem. Biophys.
434
275-281
2005
Caenorhabditis elegans, Caenorhabditis elegans (O02089)
Manually annotated by BRENDA team
Moskovitz, J.; Singh, V.K.; Requena, J.; Wilkinson, B.J.; Jayaswal, R.K.; Stadtman, E.R.
Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity
Biochem. Biophys. Res. Commun.
290
62-65
2002
Staphylococcus aureus
Manually annotated by BRENDA team
Spector, D.; Etienne, F.; Brot, N.; Weissbach, H.
New membrane-associated and soluble peptide methionine sulfoxide reductases in Escherichia coli
Biochem. Biophys. Res. Commun.
302
284-289
2003
Escherichia coli
Manually annotated by BRENDA team
Etienne, F.; Resnick, L.; Sagher, D.; Brot, N.; Weissbach, H.
Reduction of Sulindac to its active metabolite, sulindac sulfide: assay and role of the methionine sulfoxide reductase system
Biochem. Biophys. Res. Commun.
312
1005-1010
2003
Bos taurus, Escherichia coli
Manually annotated by BRENDA team
Vougier, S.; Mary, J.; Friguet, B.
Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells
Biochem. J.
373
531-537
2003
Rattus norvegicus
Manually annotated by BRENDA team
Weissbach, H.; Resnick, L.; Brot, N.
Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage
Biochim. Biophys. Acta
1703
203-212
2005
Bos taurus, Dickeya chrysanthemi, Drosophila melanogaster, Escherichia coli, Haemophilus influenzae, Helicobacter pylori, Homo sapiens, Mus musculus, Neisseria gonorrhoeae, Neisseria meningitidis, Saccharomyces cerevisiae, Streptococcus gordonii, Streptococcus pneumoniae
Manually annotated by BRENDA team
Moskovitz, J.
Methionine sulfoxide reductases: ubiquitous enzymes involved in antioxidant defense, protein regulation, and prevention of aging-associated diseases
Biochim. Biophys. Acta
1703
213-219
2005
Arabidopsis thaliana, Escherichia coli, Homo sapiens, Mus musculus, Saccharomyces cerevisiae, Staphylococcus aureus, Sus scrofa
Manually annotated by BRENDA team
Ezraty, B.; Aussel, L.; Barras, F.
Methionine sulfoxide reductases in prokaryotes
Biochim. Biophys. Acta
1703
221-229
2005
Aggregatibacter actinomycetemcomitans, Bacillus subtilis, Dickeya chrysanthemi, Escherichia coli, Helicobacter pylori, Mycobacterium tuberculosis, Mycolicibacterium smegmatis, Mycoplasma genitalium, Neisseria gonorrhoeae, Neisseria meningitidis, no activity in Aquifex aeolicus, no activity in Thermotoga maritima, Sinorhizobium meliloti, Staphylococcus aureus, Vibrio cholerae
Manually annotated by BRENDA team
Boschi-Muller, S.; Olry, A.; Antoine, M.; Branlant, G.
The enzymology and biochemistry of methionine sulfoxide reductases
Biochim. Biophys. Acta
1703
231-238
2005
Bacillus subtilis, Escherichia coli, Neisseria meningitidis, Xanthomonas campestris
Manually annotated by BRENDA team
Kauffmann, B.; Aubry, A.; Favier, F.
The three-dimensional structures of peptide methionine sulfoxide reductases: current knowledge and open questions
Biochim. Biophys. Acta
1703
249-260
2005
Bacillus subtilis, Bos taurus (P54149), Deinococcus radiodurans, Escherichia coli (P0A744), Mycobacterium tuberculosis (P9WJM5), Mycobacterium tuberculosis H37Rv (P9WJM5), Neisseria gonorrhoeae (P14930), Neisseria meningitidis, Solanum lycopersicum
Manually annotated by BRENDA team
Petropoulos, I.; Friguet, B.
Protein maintenance in aging and replicative senescence: a role for the peptide methionine sulfoxide reductases
Biochim. Biophys. Acta
1703
261-266
2005
Drosophila melanogaster, Escherichia coli, Homo sapiens, Rattus norvegicus, Saccharomyces cerevisiae
Manually annotated by BRENDA team
Picot, C.R.; Perichon, M.; Cintrat, J.C.; Friguet, B.; Petropoulos, I.
The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts
FEBS Lett.
558
74-78
2004
Homo sapiens
Manually annotated by BRENDA team
Tamburro, A.; Robuffo, I.; Heipieper, H.J.; Allocati, N.; Rotilio, D.; Di Ilio, C.; Favaloro, B.
Expression of glutathione S-transferase and peptide methionine sulphoxide reductase in Ochrobactrum anthropi is correlated to the production of reactive oxygen species caused by aromatic substrates
FEMS Microbiol. Lett.
241
151-156
2004
Ochrobactrum anthropi
Manually annotated by BRENDA team
Taylor, A.B.; Benglis, D.M., Jr.; Dhandayuthapani, S.; Hart, P.J.
Structure of Mycobacterium tuberculosis methionine sulfoxide reductase A in complex with protein-bound methionine
J. Bacteriol.
185
4119-4126
2003
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Antoine, M.; Boschi-Muller, S.; Branlant, G.
Kinetic characterization of the chemical steps involved in the catalytic mechanism of methionine sulfoxide reductase A from Neisseria meningitidis
J. Biol. Chem.
278
45352-45357
2003
Neisseria meningitidis
Manually annotated by BRENDA team
Vougier, S.; Mary, J.; Dautin, N.; Vinh, J.; Friguet, B.; Ladant, D.
Essential role of methionine residues in calmodulin binding to Bordetelle pertussis adenylate cyclase, as probed by selective oxidation and repair by the peptide methionine sulfoxide reductases
J. Biol. Chem.
279
30210-30218
2004
Rattus norvegicus
Manually annotated by BRENDA team
Singh, V.K.; Moskovitz, J.
Multiple methionine sulfoxide reductase genes in Staphylococcus aureus: expression of activity and roles in tolerance of oxidative stress
Microbiology
149
2739-2747
2003
Staphylococcus aureus
Manually annotated by BRENDA team
Stadtman, E.R.; Moskovitz, J.; Berlett, B.S.; Levine, R.L.
Cyclic axidation and reduction of protein methionine residues is an important antioxidant mechanism
Mol. Cell. Biochem.
2347235
3-9
2002
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Alamuri, P.; Maier, R.J.
Methionine sulphoxide reductase is an important antioxidant enzyme in the gastric pathogen Helicobacter pylori
Mol. Microbiol.
53
1397-1406
2004
Helicobacter pylori
Manually annotated by BRENDA team
Lowther, W.T.; Weissbach, H.; Etienne, F.; Brot, N.; Matthews, B.W.
The mirrored methionine sulfoxide reductases of Neisseria gonorrhoeae pilB
Nat. Struct. Biol.
9
348-352
2002
Neisseria gonorrhoeae (P14930)
Manually annotated by BRENDA team
Gustavsson, N.; Kokke, B.P.; Harndahl, U.; Silow, M.; Bechtold, U.; Poghosyan, Z.; Murphy, D.; Boelens, W.C.; Sundby, C.
A peptide methionine sulfoxide reductase highly expressed in photosynthetic tissue in Arabidopsis thaliana can protect the chaperone-like activity of a chloroplast-localized small heat shock protein
Plant J.
29
545-553
2002
Arabidopsis thaliana
Manually annotated by BRENDA team
Romero, H.M.; Berlett, B.S.; Jensen, P.J.; Pell, E.J.; Tien, M.
Investigations into the role of the plastidial peptide methionine sulfoxide reductase in response to oxidative stress in Arabidopsis
Plant Physiol.
136
3784-3794
2004
Arabidopsis thaliana (P54150)
Manually annotated by BRENDA team
In, O.; Berberich, T.; Romdhane, S.; Feierabend, J.
Changes in gene expression during dehardening of cold-hardened winter rye (Secale cereale L.) leaves and potential role of a peptide methionine sulfoxide reductase in cold-acclimation
Planta
220
941-950
2005
Secale cereale
Manually annotated by BRENDA team
Koc, A.; Gasch, A.P.; Rutherford, J.C.; Kim, H.Y.; Gladyshev, V.N.
Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging
Proc. Natl. Acad. Sci. USA
101
7999-8004
2004
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Manually annotated by BRENDA team
Kantorow, M.; Hawse, J.R.; Cowell, T.L.; Benhamed, S.; Pizarro, G.O.; Reddy, V.N.; Hejtmancik, J.F.
Methionine sulfoxide reductase A is important for lens cell viability and resistance to oxidative stress
Proc. Natl. Acad. Sci. USA
101
9654-9659
2004
Homo sapiens
Manually annotated by BRENDA team
Tete-Favier, F.; Cobessi, D.; Leonard, G.A.; Azza, S.; Talfournier, F.; Boschi-Muller, S.; Branlant, G.; Aubry, A.
Crystallization and preliminary X-ray diffraction studies of the peptide methionine sulfoxide reductase from Escherichia coli
Acta Crystallogr. Sect. D
56
1194-1197
2000
Escherichia coli
Manually annotated by BRENDA team
Schallreuter, K.U.; Rubsam, K.; Chavan, B.; Zothner, C.; Gillbro, J.M.; Spencer, J.D.; Wood, J.M.
Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus
Biochem. Biophys. Res. Commun.
342
145-152
2006
Homo sapiens
Manually annotated by BRENDA team
Kim, H.Y.; Gladyshev, V.N.
Role of structural and functional elements of mouse methionine-S-sulfoxide reductase in its subcellular distribution
Biochemistry
44
8059-8067
2005
Mus musculus
Manually annotated by BRENDA team
Kim, H.Y.; Gladyshev, V.N.
Alternative first exon splicing regulates subcellular distribution of methionine sulfoxide reductases
BMC Mol. Biol.
7
11
2006
Drosophila melanogaster (P08761), Homo sapiens, Homo sapiens (Q9UJ68), Mus musculus (Q9D6Y7)
Manually annotated by BRENDA team
Moskovitz, J.
Roles of methionine suldfoxide reductases in antioxidant defense, protein regulation and survival
Curr. Pharm. Des.
11
1451-1457
2005
Arabidopsis thaliana, Escherichia coli, Homo sapiens, Mus musculus, Saccharomyces cerevisiae, Staphylococcus aureus, Sus scrofa
Manually annotated by BRENDA team
Lee, J.W.; Gordiyenko, N.V.; Marchetti, M.; Tserentsoodol, N.; Sagher, D.; Alam, S.; Weissbach, H.; Kantorow, M.; Rodriguez, I.R.
Gene structure, localization and role in oxidative stress of methionine sulfoxide reductase A (MSRA) in the monkey retina
Exp. Eye Res.
82
816-827
2006
Macaca mulatta
Manually annotated by BRENDA team
Kuschel, L.; Hansel, A.; Schonherr, R.; Weissbach, H.; Brot, N.; Hoshi, T.; Heinemann, S.H.
Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA)
FEBS Lett.
456
17-21
1999
Homo sapiens
Manually annotated by BRENDA team
Hanbauer, I.; Moskovitz, J.
The yeast cytosolic thioredoxins are involved in the regulation of methionine sulfoxide reductase A
Free Radic. Biol. Med.
40
1391-1396
2006
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4743
Manually annotated by BRENDA team
Beraud, S.; Bersch, B.; Brutscher, B.; Gans, P.; Barras, F.; Blackledge, M.
Direct structure determination using residual dipolar couplings: reaction-site conformation of methionine sulfoxide reductase in solution
J. Am. Chem. Soc.
124
13709-13715
2002
Dickeya chrysanthemi, Escherichia coli (P0A744)
Manually annotated by BRENDA team
Vattanaviboon, P.; Seeanukun, C.; Whangsuk, W.; Utamapongchai, S.; Mongkolsuk, S.
Important role for methionine sulfoxide reductase in the oxidative stress response of Xanthomonas campestris pv. phaseoli
J. Bacteriol.
187
5831-5836
2005
Xanthomonas campestris (Q8VS50)
Manually annotated by BRENDA team
Ogawa, F.; Sander, C.S.; Hansel, A.; Oehrl, W.; Kasperczyk, H.; Elsner, P.; Shimizu, K.; Heinemann, S.H.; Thiele, J.J.
The repair enzyme peptide methionine-S-sulfoxide reductase is expressed in human epidermis and upregulated by UVA radiation
J. Invest. Dermatol.
126
1128-1134
2006
Homo sapiens
Manually annotated by BRENDA team
Mintz, K.P.; Moskovitz, J.; Wu, H.; Fives-Taylor, P.M.
Peptide methionine sulfoxide reductase (MsrA) is not a major virulence determinant for the oral pathogen Actinobacillus actinomycetemcomitans
Microbiology
148
3695-3703
2002
Aggregatibacter actinomycetemcomitans (Q9AL99)
Manually annotated by BRENDA team
Romero, H.M.; Pell, E.J.; Tien, M.
Expression profile analysis and biochemical properties of the peptide methionine sulfoxide reductase A (PMSRA) gene family in Arabidopsis
Plant Sci.
170
705-714
2006
Arabidopsis thaliana (P54150), Arabidopsis thaliana (Q9SL43)
-
Manually annotated by BRENDA team
Yermolaieva, O.; Xu, R.; Schinstock, C.; Brot, N.; Weissbach, H.; Heinemann, S.H.; Hoshi, T.
Methionine sulfoxide reductase A protects neuronal cells against brief hypoxia/reoxygenation
Proc. Natl. Acad. Sci. USA
101
1159-1164
2004
Bos taurus
Manually annotated by BRENDA team
Moskovitz, J.; Flescher, E.; Berlett, B.S.; Azare, J.; Poston, J.M.; Stadtman, E.R.
Overexpression of peptide-methionine sulfoxide reductase in Saccharomyces cerevisiae and human T cells provides them with high resistance to oxidative stress
Proc. Natl. Acad. Sci. USA
95
14071-14075
1998
Saccharomyces cerevisiae
Manually annotated by BRENDA team
El Hassouni, M.; Chambost, J.P.; Expert, D.; Van Gijsegem, F.; Barras, F.
The minimal gene set member msrA, encoding peptide methionine sulfoxide reductase, is a virulence determinant of the plant pathogen Erwinia chrysanthemi
Proc. Natl. Acad. Sci. USA
96
887-892
1999
Dickeya chrysanthemi
Manually annotated by BRENDA team
Skaar, E.P.; Tobiason, D.M.; Quick, J.; Judd, R.C.; Weissbach, H.; Etienne, F.; Brot, N.; Seifert, H.S.
The outer membrane localization of the Neisseria gonorrhoeae MsrA/B is involved in survival against reactive oxygen species
Proc. Natl. Acad. Sci. USA
99
10108-10113
2002
Neisseria gonorrhoeae, Neisseria gonorrhoeae MS11
Manually annotated by BRENDA team
Cabreiro, F.; Picot, C.R.; Perichon, M.; Friguet, B.; Petropoulos, I.
Overexpression of methionine sulfoxide reductases A and B2 protects MOLT-4 cells against zinc-induced oxidative stress
Antioxid. Redox Signal.
11
215-225
2009
Homo sapiens (A6NCQ5)
Manually annotated by BRENDA team
Boschi-Muller, S.; Gand, A.; Branlant, G.
The methionine sulfoxide reductases: Catalysis and substrate specificities
Arch. Biochem. Biophys.
474
266-273
2008
Escherichia coli, Neisseria meningitidis (Q9JWM8)
Manually annotated by BRENDA team
Roesijadi, G.; Rezvankhah, S.; Binninger, D.M.; Weissbach, H.
Ecdysone induction of MsrA protects against oxidative stress in Drosophila
Biochem. Biophys. Res. Commun.
354
511-516
2007
Drosophila melanogaster
Manually annotated by BRENDA team
Kim, H.Y.; Kim, J.R.
Thioredoxin as a reducing agent for mammalian methionine sulfoxide reductases B lacking resolving cysteine
Biochem. Biophys. Res. Commun.
371
490-494
2008
Mus musculus (Q9D6Y7)
Manually annotated by BRENDA team
Kim, H.Y.; Gladyshev, V.N.
Methionine sulfoxide reductases: selenoprotein forms and roles in antioxidant protein repair in mammals
Biochem. J.
407
321-329
2007
Bos taurus, Escherichia coli, Homo sapiens, Mus musculus (Q9D6Y7), Mycobacterium tuberculosis, Neisseria gonorrhoeae, Neisseria meningitidis, Populus trichocarpa
Manually annotated by BRENDA team
Chen, B.; Markillie, L.M.; Xiong, Y.; Mayer, M.U.; Squier, T.C.
Increased catalytic efficiency following gene fusion of bifunctional methionine sulfoxide reductase enzymes from Shewanella oneidensis
Biochemistry
46
14153-14161
2007
Shewanella oneidensis
Manually annotated by BRENDA team
Le, D.T.; Liang, X.; Fomenko, D.E.; Raza, A.S.; Chong, C.K.; Carlson, B.A.; Hatfield, D.L.; Gladyshev, V.N.
Analysis of methionine/selenomethionine oxidation and methionine sulfoxide reductase function using methionine-rich proteins and antibodies against their oxidized forms
Biochemistry
47
6685-6694
2008
Mus musculus (Q9D6Y7)
Manually annotated by BRENDA team
Quinternet, M.; Tsan, P.; Neiers, F.; Beaufils, C.; Boschi-Muller, S.; Averlant-Petit, M.C.; Branlant, G.; Cung, M.T.
Solution structure and dynamics of the reduced and oxidized forms of the N-terminal domain of PilB from Neisseria meningitidis
Biochemistry
47
8577-8589
2008
Neisseria meningitidis
Manually annotated by BRENDA team
Cabreiro, F.; Picot, C.R.; Perichon, M.; Mary, J.; Friguet, B.; Petropoulos, I.
Identification of proteins undergoing expression level modifications in WI-38 SV40 fibroblasts overexpressing methionine sulfoxide reductase A
Biochimie
89
1388-1395
2007
Homo sapiens, Homo sapiens (Q9UJ68)
Manually annotated by BRENDA team
Zhang, X.H.; Weissbach, H.
Origin and evolution of the protein-repairing enzymes methionine sulphoxide reductases
Biol. Rev. Camb. Philos. Soc.
83
249-257
2008
Clostridium tetani, Clostridium tetani E88, Ferroplasma acidarmanus, Haloarcula marismortui, Halobacterium salinarum, Halobacterium salinarum NRC 1, Methanococcoides burtonii, Methanococcus maripaludis, Methanosarcina acetivorans, Methanosarcina barkeri, Methanosarcina barkeri Fusaro / DSM 804, Methanosarcina mazei, Methanothermobacter thermautotrophicus, Natronomonas pharaonis, no activity in Aeropyrum pernix K1, no activity in Archaeoglobus fulgidus DSM 4304, no activity in Bifidobacterium longum, no activity in Bifidobacterium longum NCC2705, no activity in Methanocaldococcus jannaschii, no activity in Methanopyrus kandleri, no activity in Methanopyrus kandleri AV19, no activity in Nanoarchaeum equitans, no activity in Nanoarchaeum equitans Kin4-M, no activity in Pyrobaculum aerophilum, no activity in Pyrobaculum aerophilum IM2, no activity in Pyrococcus abyssi, no activity in Pyrococcus abyssi GE5, no activity in Pyrococcus furiosus, no activity in Pyrococcus horikoshii, no activity in Pyrococcus horikoshii OT3, no activity in Sulfolobus tokodaii, no activity in Sulfolobus tokodaii 7, no activity in Thermoplasma acidophilum, no activity in Thermoplasma volcanium, no activity in Thermoplasma volcanium GSS1, Picrophilus torridus, Saccharolobus solfataricus, Saccharolobus solfataricus P2, Sulfolobus acidocaldarius, Thermococcus kodakarensis
Manually annotated by BRENDA team
Lei, K.F.; Wang, Y.F.; Zhu, X.Q.; Lu, P.C.; Sun, B.S.; Jia, H.L.; Ren, N.; Ye, Q.H.; Sun, H.C.; Wang, L.; Tang, Z.Y.; Qin, L.X.
Identification of MSRA gene on chromosome 8p as a candidate metastasis suppressor for human hepatitis B virus-positive hepatocellular carcinoma
BMC Cancer
7
172
2007
Homo sapiens
Manually annotated by BRENDA team
You, C.; Sekowska, A.; Francetic, O.; Martin-Verstraete, I.; Wang, Y.; Danchin, A.
Spx mediates oxidative stress regulation of the methionine sulfoxide reductases operon in Bacillus subtilis
BMC Microbiol.
8
128
2008
Bacillus subtilis
Manually annotated by BRENDA team
Pal, R.; Oien, D.B.; Ersen, F.Y.; Moskovitz, J.
Elevated levels of brain-pathologies associated with neurodegenerative diseases in the methionine sulfoxide reductase A knockout mouse
Exp. Brain Res.
180
765-774
2007
Mus musculus, Mus musculus (Q9D6Y7)
Manually annotated by BRENDA team
Picot, C.R.; Moreau, M.; Juan, M.; Noblesse, E.; Nizard, C.; Petropoulos, I.; Friguet, B.
Impairment of methionine sulfoxide reductase during UV irradiation and photoaging
Exp. Gerontol.
42
859-863
2007
Homo sapiens, Homo sapiens (Q9UJ68), Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Oien, D.B.; Osterhaus, G.L.; Latif, S.A.; Pinkston, J.W.; Fulks, J.; Johnson, M.; Fowler, S.C.; Moskovitz, J.
MsrA knockout mouse exhibits abnormal behavior and brain dopamine levels
Free Radic. Biol. Med.
45
193-200
2008
Mus musculus, Mus musculus (Q9D6Y7)
Manually annotated by BRENDA team
Liu, F.; Hindupur, J.; Nguyen, J.L.; Ruf, K.J.; Zhu, J.; Schieler, J.L.; Bonham, C.C.; Wood, K.V.; Davisson, V.J.; Rochet, J.C.
Methionine sulfoxide reductase A protects dopaminergic cells from Parkinsons disease-related insults
Free Radic. Biol. Med.
45
242-255
2008
Bos taurus (P54149)
Manually annotated by BRENDA team
Haenold, R.; Wassef, R.; Hansel, A.; Heinemann, S.H.; Hoshi, T.
Identification of a new functional splice variant of the enzyme methionine sulphoxide reductase A (MSRA) expressed in rat vascular smooth muscle cells
Free Radic. Res.
41
1233-1245
2007
Rattus norvegicus (Q923M1)
Manually annotated by BRENDA team
Moskovitz, J.
Prolonged selenium-deficient diet in MsrA knockout mice causes enhanced oxidative modification to proteins and affects the levels of antioxidant enzymes in a tissue-specific manner
Free Radic. Res.
41
162-171
2007
Mus musculus (Q9D6Y7)
Manually annotated by BRENDA team
Fukushima, E.; Shinka, Y.; Fukui, T.; Atomi, H.; Imanaka, T.
Methionine sulfoxide reductase from the hyperthermophilic archaeon Thermococcus kodakaraensis, an enzyme designed to function at suboptimal growth temperatures
J. Bacteriol.
189
7134-7144
2007
Thermococcus kodakarensis
Manually annotated by BRENDA team
Gand, A.; Antoine, M.; Boschi-Muller, S.; Branlant, G.
Characterization of the amino acids involved in substrate specificity of methionine sulfoxide reductase A
J. Biol. Chem.
282
20484-20491
2007
Neisseria meningitidis
Manually annotated by BRENDA team
Schallreuter, K.U.; Ruebsam, K.; Gibbons, N.C.; Maitland, D.J.; Chavan, B.; Zothner, C.; Rokos, H.; Wood, J.M.
Methionine sulfoxide reductases A and B are deactivated by hydrogen peroxide (H2O2) in the epidermis of patients with vitiligo
J. Invest. Dermatol.
128
808-815
2008
Homo sapiens
Manually annotated by BRENDA team
Ranaivoson, F.M.; Antoine, M.; Kauffmann, B.; Boschi-Müller, S.; Aubry, A.; Branlant, G.; Favier, F.
A structural analysis of the catalytic mechanism of methionine sulfoxide reductase A from Neisseria meningitidis
J. Mol. Biol.
377
268-280
2008
Neisseria meningitidis, Neisseria meningitidis (Q9JWM8)
Manually annotated by BRENDA team
Wassef, R.; Haenold, R.; Hansel, A.; Brot, N.; Heinemann, S.H.; Hoshi, T.
Methionine sulfoxide reductase A and a dietary supplement S-methyl-L-cysteine prevent Parkinsons-like symptoms
J. Neurosci.
27
12808-12816
2007
Homo sapiens, Homo sapiens (Q9UJ68)
Manually annotated by BRENDA team
Atack, J.M.; Kelly, D.J.
Contribution of the stereospecific methionine sulphoxide reductases MsrA and MsrB to oxidative and nitrosative stress resistance in the food-borne pathogen Campylobacter jejuni
Microbiology
154
2219-2230
2008
Campylobacter jejuni, Campylobacter jejuni NCTC 11168
Manually annotated by BRENDA team
Minniti, A.N.; Cataldo, R.; Trigo, C.; Vasquez, L.; Mujica, P.; Leighton, F.; Inestrosa, N.C.; Aldunate, R.
Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans
Aging Cell
8
690-705
2009
Caenorhabditis elegans, Caenorhabditis elegans N2
Manually annotated by BRENDA team
Ogawa, F.; Shimizu, K.; Hara, T.; Muroi, E.; Komura, K.; Takenaka, M.; Hasegawa, M.; Fujimoto, M.; Takehara, K.; Sato, S.
Autoantibody against one of the antioxidant repair enzymes, methionine sulfoxide reductase A, in systemic sclerosis: association with pulmonary fibrosis and vascular damage
Arch. Dermatol. Res.
302
27-35
2010
Homo sapiens, Homo sapiens (Q9UJ68)
Manually annotated by BRENDA team
Brennan, L.A.; Lee, W.; Giblin, F.J.; David, L.L.; Kantorow, M.
Methionine sulfoxide reductase A (MsrA) restores alpha-crystallin chaperone activity lost upon methionine oxidation
Biochim. Biophys. Acta
1790
1665-1672
2009
Homo sapiens (Q9UJ68), Mus musculus (Q9D6Y7)
Manually annotated by BRENDA team
Salmon, A.B.; Perez, V.I.; Bokov, A.; Jernigan, A.; Kim, G.; Zhao, H.; Levine, R.L.; Richardson, A.
Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span
FASEB J.
23
3601-3608
2009
Mus musculus
Manually annotated by BRENDA team
Soriani, F.M.; Kress, M.R.; Fagundes de Gouvea, P.; Malavazi, I.; Savoldi, M.; Gallmetzer, A.; Strauss, J.; Goldman, M.H.; Goldman, G.H.
Functional characterization of the Aspergillus nidulans methionine sulfoxide reductases (msrA and msrB)
Fungal Genet. Biol.
46
410-417
2009
Aspergillus nidulans
Manually annotated by BRENDA team
Pascual, I.; Larrayoz, I.M.; Rodriguez, I.R.
Retinoic acid regulates the human methionine sulfoxide reductase A (MSRA) gene via two distinct promoters
Genomics
93
62-71
2009
Homo sapiens, Homo sapiens (Q9UJ68)
Manually annotated by BRENDA team
Le, H.T.; Chaffotte, A.F.; Demey-Thomas, E.; Vinh, J.; Friguet, B.; Mary, J.
Impact of hydrogen peroxide on the activity, structure, and conformational stability of the oxidized protein repair enzyme methionine sulfoxide reductase A
J. Mol. Biol.
393
58-66
2009
Rattus norvegicus (Q923M1)
Manually annotated by BRENDA team
Oien, D.B.; Osterhaus, G.L.; Lundquist, B.L.; Fowler, S.C.; Moskovitz, J.
Caloric restriction alleviates abnormal locomotor activity and dopamine levels in the brain of the methionine sulfoxide reductase A knockout mouse
Neurosci. Lett.
468
38-41
2010
Mus musculus, Mus musculus (Q9D6Y7)
Manually annotated by BRENDA team
Kim, H.Y.; Zhang, Y.; Lee, B.C.; Kim, J.R.; Gladyshev, V.N.
The selenoproteome of Clostridium sp. OhILAs: characterization of anaerobic bacterial selenoprotein methionine sulfoxide reductase A
Proteins
74
1008-1017
2009
Clostridium sp., Clostridium sp. OhILAs
Manually annotated by BRENDA team
Kwak, G.H.; Choi, S.H.; Kim, H.Y.
Dimethyl sulfoxide elevates hydrogen peroxide-mediated cell death in Saccharomyces cerevisiae by inhibiting the antioxidant function of methionine sulfoxide reductase A
BMB Rep.
43
622-628
2010
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Manually annotated by BRENDA team
Zhao, H.; Kim, G.; Liu, C.; Levine, R.L.
Transgenic mice overexpressing methionine sulfoxide reductase A: characterization of embryonic fibroblasts
Free Radic. Biol. Med.
49
641-648
2010
Mus musculus, Mus musculus (Q9D6Y7)
Manually annotated by BRENDA team
Arias, D.G.; Cabeza, M.S.; Erben, E.D.; Carranza, P.G.; Lujan, H.D.; Tellez Inon, M.T.; Iglesias, A.A.; Guerrero, S.A.
Functional characterization of methionine sulfoxide reductase A from Trypanosoma spp.
Free Radic. Biol. Med.
50
37-46
2010
Trypanosoma cruzi, Trypanosoma cruzi CL Brener
Manually annotated by BRENDA team
Kim, J.I.; Choi, S.H.; Jung, K.J.; Lee, E.; Kim, H.Y.; Park, K.M.
Protective role of methionine sulfoxide reductase A against ischemia/reperfusion injury in mouse kidney and its involvement in the regulation of trans-sulfuration pathway
Antioxid. Redox Signal.
18
2241-2250
2013
Mus musculus
Manually annotated by BRENDA team
Kwak, G.H.; Hwang, K.Y.; Kim, H.Y.
Analyses of methionine sulfoxide reductase activities towards free and peptidyl methionine sulfoxides
Arch. Biochem. Biophys.
527
1-5
2012
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Dokainish, H.M.; Gauld, J.W.
A molecular dynamics and quantum mechanics/molecular mechanics study of the catalytic reductase mechanism of methionine sulfoxide reductase A: formation and reduction of a sulfenic acid
Biochemistry
52
1814-1827
2013
Mycobacterium tuberculosis, Mycobacterium tuberculosis (P9WJM5), Mycobacterium tuberculosis H37Rv (P9WJM5)
Manually annotated by BRENDA team
Couturier, J.; Vignols, F.; Jacquot, J.P.; Rouhier, N.
Glutathione- and glutaredoxin-dependent reduction of methionine sulfoxide reductase A
FEBS Lett.
586
3894-3899
2012
Gracilaria gracilis
Manually annotated by BRENDA team
Lim, J.C.; Kim, G.; Levine, R.L.
Stereospecific oxidation of calmodulin by methionine sulfoxide reductase A
Free Radic. Biol. Med.
61C
257-264
2013
Mus musculus
Manually annotated by BRENDA team
Lim, J.C.; Gruschus, J.M.; Ghesquiere, B.; Kim, G.; Piszczek, G.; Tjandra, N.; Levine, R.L.
Characterization and solution structure of mouse myristoylated methionine sulfoxide reductase A
J. Biol. Chem.
287
25589-25595
2012
Mus musculus
Manually annotated by BRENDA team
Jia, P.; Zhang, C.; Jia, Y.; Webster, K.A.; Huang, X.; Kochegarov, A.A.; Lemanski, S.L.; Lemanski, L.F.
Identification of a truncated form of methionine sulfoxide reductase A expressed in mouse embryonic stem cells
J. Biomed. Sci.
18
46
2011
Mus musculus
Manually annotated by BRENDA team
Lim, J.C.; You, Z.; Kim, G.; Levine, R.L.
Methionine sulfoxide reductase A is a stereospecific methionine oxidase
Proc. Natl. Acad. Sci. USA
108
10472-10477
2011
Homo sapiens
Manually annotated by BRENDA team
Dai, C.; Han, W.; Wang, M.H.
Two highly homologous methionine sulfoxide reductase A from tomato (Solanum lycopersicum), exhibit distinct catalytic properties
Protein J.
31
285-292
2012
Solanum lycopersicum (G3JX11), Solanum lycopersicum (P54153), Solanum lycopersicum
Manually annotated by BRENDA team
Liu, L.; Wang, M.H.
Expression and biological properties of a novel methionine sulfoxide reductase A in tobacco (Nicotiana tabacum)
Protein J.
32
266-274
2013
Nicotiana tabacum
Manually annotated by BRENDA team
Kim, J.Y.; Kim, Y.; Kwak, G.H.; Oh, S.Y.; Kim, H.Y.
Over-expression of methionine sulfoxide reductase A in the endoplasmic reticulum increases resistance to oxidative and ER stresses
Acta Biochim. Biophys. Sin. (Shanghai)
46
415-419
2014
Mus musculus (Q9D6Y7)
Manually annotated by BRENDA team
Guan, X.L.; Wu, P.F.; Wang, S.; Zhang, J.J.; Shen, Z.C.; Luo, H.; Chen, H.; Long, L.H.; Chen, J.G.; Wang, F.
Dimethyl sulfide protects against oxidative stress and extends lifespan via a methionine sulfoxide reductase A-dependent catalytic mechanism
Aging Cell
16
226-236
2017
Caenorhabditis elegans (O02089), Drosophila melanogaster, Rattus norvegicus
Manually annotated by BRENDA team
Moskovitz, J.; Du, F.; Bowman, C.F.; Yan, S.S.
Methionine sulfoxide reductase A affects beta-amyloid solubility and mitochondrial function in a mouse model of Alzheimer's disease
Am. J. Physiol. Endocrinol. Metab.
310
E388-E393
2016
Mus musculus
Manually annotated by BRENDA team
Minniti, A.N.; Arrazola, M.S.; Bravo-Zehnder, M.; Ramos, F.; Inestrosa, N.C.; Aldunate, R.
The protein oxidation repair enzyme methionine sulfoxide reductase a modulates Abeta aggregation and toxicity in vivo
Antioxid. Redox Signal.
22
48-62
2015
Caenorhabditis elegans, Caenorhabditis elegans (O02089)
Manually annotated by BRENDA team
Si, M.; Zhang, L.; Chaudhry, M.T.; Ding, W.; Xu, Y.; Chen, C.; Akbar, A.; Shen, X.; Liu, S.J.
Corynebacterium glutamicum methionine sulfoxide reductase A uses both mycoredoxin and thioredoxin for regeneration and oxidative stress resistance
Appl. Environ. Microbiol.
81
2781-2796
2015
Corynebacterium glutamicum, Corynebacterium glutamicum (Q8NLL5), Corynebacterium glutamicum DSM 20300 (Q8NLL5)
Manually annotated by BRENDA team
Lee, E.H.; Kwak, G.H.; Kim, M.J.; Kim, H.Y.; Hwang, K.Y.
Structural analysis of 1-Cys type selenoprotein methionine sulfoxide reductase A
Arch. Biochem. Biophys.
545
1-8
2014
Alkaliphilus oremlandii (A8MI53), Alkaliphilus oremlandii, Alkaliphilus oremlandii OhILAs (A8MI53)
Manually annotated by BRENDA team
Kriznik, A.; Boschi-Muller, S.; Branlant, G.
Kinetic evidence that methionine sulfoxide reductase A can reveal its oxidase activity in the presence of thioredoxin
Arch. Biochem. Biophys.
548
54-59
2014
Escherichia coli, Escherichia coli (P0A744)
Manually annotated by BRENDA team
Kim, M.J.; Jeong, J.; Jeong, J.; Hwang, K.Y.; Lee, K.J.; Kim, H.Y.
Mechanism of 1-Cys type methionine sulfoxide reductase A regeneration by glutaredoxin
Biochem. Biophys. Res. Commun.
457
567-571
2015
Alkaliphilus oremlandii (A8MI53), Alkaliphilus oremlandii, Alkaliphilus oremlandii OhILAs (A8MI53)
Manually annotated by BRENDA team
Singh, M.P.; Kim, K.Y.; Kim, H.Y.
Methionine sulfoxide reductase A deficiency exacerbates acute liver injury induced by acetaminophen
Biochem. Biophys. Res. Commun.
484
189-194
2017
Mus musculus (Q9D6Y7)
Manually annotated by BRENDA team
Kim, G.; Levine, R.L.
A methionine residue promotes hyperoxidation of the catalytic cysteine of mouse methionine sulfoxide reductase A
Biochemistry
55
3586-3593
2016
Homo sapiens, Homo sapiens (Q9UJ68), Mus musculus, Mus musculus (Q9D6Y7)
Manually annotated by BRENDA team
Han, A.R.; Kim, M.J.; Kwak, G.H.; Son, J.; Hwang, K.Y.; Kim, H.Y.
Essential role of the linker region in the higher catalytic efficiency of a bifunctional MsrA-MsrB fusion protein
Biochemistry
55
5117-5127
2016
Treponema denticola (Q73PT7), Treponema denticola, Treponema denticola ATCC 35405 (Q73PT7)
Manually annotated by BRENDA team
Enache, T.; Oliveira-Brett, A.
Peptide methionine sulfoxide reductase A (MsrA) Direct electrochemical oxidation on carbon electrodes
Bioelectrochemistry
89
11-18
2013
Escherichia coli (P0A744)
Manually annotated by BRENDA team
Zhu, Q.; El-Mergawy, R.G.; Zhou, Y.; Chen, C.; Heinemann, S.H.; Schoenherr, R.; Robaa, D.; Sippl, W.; Scriba, G.K.
Stereospecific capillary electrophoresis assays using pentapeptide substrates for the study of Aspergillus nidulans methionine sulfoxide reductase A and mutant enzymes
Electrophoresis
37
2083-2090
2016
Aspergillus nidulans
Manually annotated by BRENDA team
Wu, P.; Zhang, Z.; Guan, X.; Li, Y.; Zeng, J.; Zhang, J.; Long, L.; Hu, Z.; Wang, F.; Chen, J.
A specific and rapid colorimetric method to monitor the activity of methionine sulfoxide reductase A
Enzyme Microb. Technol.
53
391-397
2013
Rattus norvegicus (Q923M1)
Manually annotated by BRENDA team
Saha, S.; Hashino, M.; Suzuki, J.; Uda, A.; Watanabe, K.; Shimizu, T.; Watarai, M.
Contribution of methionine sulfoxide reductase B (MsrB) to Francisella tularensis infection in mice
FEMS Microbiol. Lett.
364
0000
2017
Francisella tularensis subsp. holarctica (A0A0B6CP33)
Manually annotated by BRENDA team
Dun, Y.; Vargas, J.; Brot, N.; Finnemann, S.C.
Independent roles of methionine sulfoxide reductase A in mitochondrial ATP synthesis and as antioxidant in retinal pigment epithelial cells
Free Radic. Biol. Med.
65
1340-1351
2013
Rattus norvegicus
Manually annotated by BRENDA team
Trivedi, R.N.; Agarwal, P.; Kumawat, M.; Pesingi, P.K.; Gupta, V.K.; Goswami, T.K.; Mahawar, M.
Methionine sulfoxide reductase A (MsrA) contributes to Salmonella Typhimurium survival against oxidative attack of neutrophils
Immunobiology
220
1322-1327
2015
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Benoit, S.L.; Bayyareddy, K.; Mahawar, M.; Sharp, J.S.; Maier, R.J.
Alkyl hydroperoxide reductase repair by Helicobacter pylori methionine sulfoxide reductase
J. Bacteriol.
195
5396-5401
2013
Helicobacter pylori
Manually annotated by BRENDA team
Lee, E.H.; Lee, K.; Kwak, G.H.; Park, Y.S.; Lee, K.J.; Hwang, K.Y.; Kim, H.Y.
Evidence for the dimerization-mediated catalysis of methionine sulfoxide reductase A from Clostridium oremlandii
PLoS ONE
10
e0131523
2015
Alkaliphilus oremlandii (A8MI53), Alkaliphilus oremlandii, Alkaliphilus oremlandii OhILAs (A8MI53)
Manually annotated by BRENDA team
Sansom, F.M.; Tang, L.; Ralton, J.E.; Saunders, E.C.; Naderer, T.; McConville, M.J.
Leishmania major methionine sulfoxide reductase A is required for resistance to oxidative stress and efficient replication in macrophages
PLoS ONE
8
e56064
2013
Leishmania major, Leishmania major (Q4QIH2)
Manually annotated by BRENDA team
Dixit, S.K.; Hota, D.P.; Rajan, P.; Mishra, P.K.; Goswami, T.K.; Mahawar, M.
Salmonella Typhimurium methionine sulfoxide reductase A (MsrA) prefers TrxA in repairing methionine sulfoxide
Prep. Biochem. Biotechnol.
47
137-142
2017
Salmonella enterica (S5PLQ5)
Manually annotated by BRENDA team