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IUBMB CommentsThe enzyme in brain transfers long-chain acyl residues to the endogenous myelin proteolipid
The expected taxonomic range for this enzyme is: Rattus norvegicus
Synonyms
Acyl-protein synthetase, myelin PLP acyltransferase, synthetase, acyl protein,
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Acyl-protein synthetase
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myelin PLP acyltransferase
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synthetase, acyl protein
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palmitoyl-CoA + [myelin proteolipid] = CoA + O-palmitoyl-[myelin proteolipid]
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Acyl group transfer
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palmitoyl-CoA:[myelin-proteolipid] O-palmitoyltransferase
The enzyme in brain transfers long-chain acyl residues to the endogenous myelin proteolipid
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myristoyl-CoA + myelin proteolipid protein
CoA + myelin proteolipid O-myristoylprotein
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low activity
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oleoyl-CoA + myelin proteolipid protein
CoA + myelin proteolipid O-oleoylprotein
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palmitoyl-CoA + myelin proteolipid protein
CoA + myelin proteolipid O-palmitoylprotein
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stearoyl-CoA + myelin proteolipid protein
CoA + myelin proteolipid O-stearoylprotein
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additional information
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enzyme is probably involved in the acylation of endogenous myelin proteolipid protein
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palmitoyl-CoA + myelin proteolipid protein
CoA + myelin proteolipid O-palmitoylprotein
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additional information
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enzyme is probably involved in the acylation of endogenous myelin proteolipid protein
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Sodium dodecyl sulfate
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at concentration 0.5%: 92% loss of activity
Tween 20
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inhibits slightly at 0.5%
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dithiothreitol
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1 mM, slightly stimulates
Nonidet P-40
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stimulates at 0.05%
octyl glucoside
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slight stimulation
sodium deoxycholate
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stimulates at 0.5%
Triton X-100
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0.1%, stimulates
Tween 20
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0.05%, slight stimulation
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6 - 8
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25% of maximal activity at pH 6, 90% of maximal activity at pH 8
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10 - 50
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45% of maximal acticity at 10°C, 75% of maximal activity at 50°C
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brenda
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labeled product also found in vitro in brain tissue slices
brenda
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75
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5 min, complete loss of activity
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freezing and thawing causes marked decrease in activity
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Bizzozero, O.A.; McGarry, J.F.; Lees, M.B.
Acylation of endogenous myelin proteolipid protein with different acyl-CoAs
J. Biol. Chem.
262
2138-2145
1987
Rattus norvegicus
brenda
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