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Information on EC 2.3.1.256 - N-terminal methionine Nalpha-acetyltransferase NatC

for references in articles please use BRENDA:EC2.3.1.256
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IUBMB Comments
N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic, and may also play a role in membrane targeting and gene silencing. The NatC complex is found in all eukaryotic organisms, and specifically targets N-terminal L-methionine residues attached to bulky hydrophobic residues at the second position, including Leu, Ile, Phe, Trp, and Tyr residues.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
mak10, mak3p, naa30, nat12, naa38, naa35, mak31p, mak31, hnaa30, n-terminal acetyltransferase complex c, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + an N-terminal-L-methionyl-L-isoleucyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA
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acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[protein] + CoA
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acetyl-CoA + an N-terminal-L-methionyl-L-phenylalanyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA
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acetyl-CoA + an N-terminal-L-methionyl-L-tryptophyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA
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acetyl-CoA + an N-terminal-L-methionyl-L-tyrosyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA
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(5)
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PATHWAY SOURCE
PATHWAYS
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