Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl = N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl = N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
mechanism
-
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl = N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
mechanism
-
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl = N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
mechanism
-
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl = N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
mechanism
-
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl = N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
mechanism
-
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl = N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
a single cytosolic protein catalyzes N-acetylation, O-acetylation and N,O-acetylation
-
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl = N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
a single cytosolic protein catalyzes N-acetylation, O-acetylation and N,O-acetylation
-
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl = N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
a single cytosolic protein catalyzes N-acetylation, O-acetylation and N,O-acetylation
-
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl = N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
a single cytosolic protein catalyzes N-acetylation, O-acetylation and N,O-acetylation
-
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl = N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
ratio of N-acetylation of arylamines, O-aectylation of arylhydroxylamines and N,O-acetylation of arylhydroxamic acids, which are all performed by a single protein, may be highly dependent on the conformation of the enzyme
-
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl = N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
7-acetyl-N-hydroxy-2-acetylaminofluorene + 4-aminoazobenzene
7-acetyl-N-hydroxy-2-aminofluorene + N-acetoxy-4-aminoazobenzene
-
-
-
-
?
7-bromo-N-hydroxy-2-acetylaminofluorene + 4-aminoazobenzene
7-bromo-N-hydroxy-2-aminofluorene + N-acetoxy-4-aminoazobenzene
-
-
-
-
?
7-ethoxy-N-hydroxy-2-acetylaminofluorene + 4-aminoazobenzene
7-ethoxy-N-hydroxy-2-aminofluorene + N-acetoxy-4-aminoazobenzene
-
-
-
-
?
7-ethyl-N-hydroxy-2-acetylaminofluorene + 4-aminoazobenzene
7-ethyl-N-hydroxy-2-aminofluorene + N-acetoxy-4-aminoazobenzene
-
-
-
-
?
acetyl-CoA + 4-aminoveratrole
CoA + N-acetyl-4-aminoveratrole
-
-
-
?
acetyl-CoA + 4-anisidine
CoA + N-acetyl-4-anisidine
-
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + N-acetyl-4-iodoaniline
-
-
-
?
N-hydroxy-2-acetylaminofluorene + 4-aminoazobenzene
N-hydroxy-2-aminofluorene + N-acetoxy-4-aminoazobenzene
-
-
-
-
?
N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl
N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl
N-hydroxy-2-propylaminofluorene + ?
?
-
i.e. N-hydroxy-N2-fluorenylpropionamide
-
-
?
N-hydroxy-4-acetylaminobiphenyl + 4-aminoazobenzene
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminoazobenzene
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
additional information
?
-
N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl
N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl
-
-
-
?
N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl
N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl
-
-
-
?
N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl
N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl
-
-
-
?
N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl
N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl
-
-
-
r
N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl
N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl
-
-
-
-
?
N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl
N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl
-
-
-
-
?
N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl
N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl
-
-
-
?
N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl
N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl
-
-
-
?
N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl
N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl
-
i.e. N-hydroxy-N2-fluorenylacetamide, not mammary gland enzyme
-
-
?
N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl
N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl
-
-
-
-
?
N-hydroxy-4-acetylaminobiphenyl + 4-aminoazobenzene
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminoazobenzene
-
-
-
?
N-hydroxy-4-acetylaminobiphenyl + 4-aminoazobenzene
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminoazobenzene
-
-
-
-
?
N-hydroxy-4-acetylaminobiphenyl + 4-aminoazobenzene
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminoazobenzene
-
-
?
N-hydroxy-4-acetylaminobiphenyl + 4-aminoazobenzene
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminoazobenzene
-
-
-
?
N-hydroxy-4-acetylaminobiphenyl + 4-aminoazobenzene
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminoazobenzene
-
-
-
?
N-hydroxy-4-acetylaminobiphenyl + 4-aminoazobenzene
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminoazobenzene
-
-
-
-
?
N-hydroxy-4-acetylaminobiphenyl + 4-aminoazobenzene
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminoazobenzene
-
-
?
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
-
-
r
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
S-acetyl-CoA cannot replace N-hydroxy-4-acetylaminobiphenyl
-
?
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
S-acetyl-CoA cannot replace N-hydroxy-4-acetylaminobiphenyl
-
?
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
S-acetyl-CoA cannot replace N-hydroxy-4-acetylaminobiphenyl
-
?
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
S-acetyl-CoA cannot replace N-hydroxy-4-acetylaminobiphenyl
-
?
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
transfers the N-acetyl group of some aromatic acethydroxamic acids to the O-position of some aromatic hydroxylamines
-
-
?
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
noninducible, no known natural substrate in rat
-
-
?
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
noninducible, no known natural substrate in rat
-
-
?
additional information
?
-
-
important for the activation of urinary metabolites of carcinogenic arylamines for the initiation of bladder carcinogenesis in the dog
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
7-substituted-N-hydroxy-2-acetylamino fluorenes form adducts with DNA, which is inhibited by addition of ascorbic acid, 4-(2-biphenyl)-2-hydroxytetronic acid, and partly by N-tert-butyl-alpha-phenylnitrone, triethylphosphite, potassium O-ethylxanthate, thiourea, and N-acetylmethionine, not in case of 7-acetyl-N-hydroxy-2-acetylamino fluorene
-
-
?
additional information
?
-
-
metabolic activation by isoforms 1 and 2 of 3-nitrobenzanthrone and N-acetyl-N-hydroxy-3-aminobenzantrone, 2 compounds with high mutagenic and genotoxic potential, formation of DNA adducts
-
-
?
additional information
?
-
-
acetohydroxamic acids with the N-atom of the hydroxamic acid group attached directly to aliphatic or cycloalkyl groups are no substrates or inhibitors
-
-
?
additional information
?
-
-
acetohydroxamic acids with the N-atom of the hydroxamic acid group attached directly to aliphatic or cycloalkyl groups are no substrates or inhibitors
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
additional information
?
-
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
transfers the N-acetyl group of some aromatic acethydroxamic acids to the O-position of some aromatic hydroxylamines
-
-
?
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
noninducible, no known natural substrate in rat
-
-
?
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl
N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
noninducible, no known natural substrate in rat
-
-
?
additional information
?
-
-
important for the activation of urinary metabolites of carcinogenic arylamines for the initiation of bladder carcinogenesis in the dog
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
metabolic activation by isoforms 1 and 2 of 3-nitrobenzanthrone and N-acetyl-N-hydroxy-3-aminobenzantrone, 2 compounds with high mutagenic and genotoxic potential, formation of DNA adducts
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-(fluoren-2-yl)-2-propen-1-one
-
irreversible and selective inactivation
7-Substituted N-hydroxy-2-acetamidofluorenes
-
residues: H, halo, CN, acetoxy, methoxy, ethoxy, butoxy, inhibition kinetics
N-Acetamido-N-hydroxy-7-methoxyfluorene
-
inhibition kinetics
N-Hydroxy-2-acetylaminofluorene
N-Hydroxy-4-acetylaminobiphenyl
trans-N-Hydroxy-4-acetylaminostilbene
additional information
-
no inhibition by paraoxon
-
N-Hydroxy-2-acetylaminofluorene
-
irreversible, suicide substrate
N-Hydroxy-2-acetylaminofluorene
-
irreversible, suicide substrate
N-Hydroxy-4-acetylaminobiphenyl
-
-
N-Hydroxy-4-acetylaminobiphenyl
-
-
trans-N-Hydroxy-4-acetylaminostilbene
-
no protection by GSH, cysteine or N-acetylmethionine
trans-N-Hydroxy-4-acetylaminostilbene
-
no protection by GSH, cysteine or N-acetylmethionine
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Hein, D.; Doll, M.; Rustan, T.; Ferguson, R.
Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: effects of 7 specific NAT2 nucleic acid substitutions
Cancer Res.
55
3531-3536
1995
Homo sapiens
brenda
Sinclair, J.; Delgoda, R.; Noble, M.; Jarmin, S.; Goh, N.; Sim, E.
Purification, characterization and crystallization of an N-hydroxyarylamine O-acetyltransferase from Salmonella typhimurium
Protein Expr. Purif.
12
371-380
1998
Salmonella enterica subsp. enterica serovar Typhimurium
brenda
Hein, D.W.
Acetylator genotype and arylamine-induced carcinogenesis
Biochim. Biophys. Acta
948
37-66
1988
Oryctolagus cuniculus, Mesocricetus auratus, no activity in Cavia porcellus, no activity in Mus musculus, Rattus norvegicus
brenda
Bartsch, H.; Dworkin, C.; Miller, E.C.; Miller, J.A.
Formation of electrophilic N-acetoxyarylamines in cytosols from rat mammary gland and other tissues by transacetylation from the carcinogen N-hydroxy-4-acetylaminobiphenyl
Biochim. Biophys. Acta
304
42-55
1973
Rattus norvegicus
brenda
Banks, R.B.; Hanna, P.E.
Arylhydroxamic acid N,O-acyltransferase. Apparent suicide inactivation by carcinogenic N-arylhydroxamic acids
Biochem. Biophys. Res. Commun.
91
1423-1429
1979
Mesocricetus auratus, Rattus norvegicus
brenda
Allaben, W.T.; King, C.M.
The purification of rat liver arylhydroxamic acid N,O-acyltransferase
J. Biol. Chem.
259
12128-12134
1984
Rattus norvegicus, Rattus norvegicus Sprague-Dawley CD
brenda
Marhevka, V.C.; Ebner, N.A.; Sehon, R.D.; Hanna, P.E.
Mechanism-based inactivation of N-arylhydroxamic acid N,O-acyltransferase by 7-substituted-N-hydroxy-2-acetamidofluorenes
J. Med. Chem.
28
18-24
1985
Mesocricetus auratus
brenda
Elfarra, A.A.; Yeh, H.M.; Hanna, P.E.
Synthesis and evaluation of N-(phenylalkyl)acetohydroxamic acids as potential substrates for N-arylhydroxamic acid N,O-acyltransferase
J. Med. Chem.
25
1189-1192
1982
Mesocricetus auratus, Rattus norvegicus
brenda
King, C.M.
Mechanism of reaction, tissue distribution, and inhibition of arylhydroxamic acid acyltransferase
Cancer Res.
34
1503-1515
1974
Rattus norvegicus
brenda
Land, S.J.; King, C.M.
Characterization of rat hepatic acetyltransferase
Environ. Health Perspect.
102
91-93
1994
Rattus norvegicus
-
brenda
Hanna, P.E.
N-acetyltransferases, O-acetyltransferases, and N,O-acetyltransferases: enzymology and bioactivation
Adv. Pharmacol.
27
401-430
1994
Homo sapiens, Mesocricetus auratus, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
brenda
Arlt, V.M.; Glatt, H.; Muckel, E.; Pabel, U.; Sorg, B.L.; Schmeiser, H.H.; Phillips, D.H.
Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase
Carcinogenesis
23
1937-1945
2002
Homo sapiens
brenda
Jones, R.F.; Land, S.J.; King, C.M.
Recombinant rat and hamster N-acetyltransferases-1 and -2: relative rates of N-acetylation of arylamines and N,O-acyl transfer with arylhydroxamic acids
Carcinogenesis
17
1729-1733
1996
Mesocricetus auratus (P50292), Mesocricetus auratus (P50293), Rattus norvegicus (P50297), Rattus norvegicus (P50298)
brenda
Sone, T.; Zukowski, K.; Land, S.J.; Kin, C.M.; Martin, B.M.; Pohl, L.R.; Wang, C.Y.
Characteristics of a purified dog hepatic microsomal N,O-acyltransferase
Carcinogenesis
15
595-599
1994
Canis lupus familiaris, Homo sapiens, Rattus norvegicus
brenda
Boteju, L.W.; Hanna, P.E.
Bioactivation of N-hydroxy-2-acetylaminofluorenes by N,O-acyltransferase: substituent effects on covalent binding to DNA
Carcinogenesis
14
1651-1657
1993
Homo sapiens
brenda