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(6Z,10E,14E,18E,22E)-3,7,15,19,23,27-hexamethyl-11-[(naphthalen-1-ylamino)methyl]octacosa-6,10,14,18,22,26-hexaen-1-yl dihydrogen phosphate + dolichyl phosphate
?
-
-
-
-
?
(6Z,10Z,14Z,18Z,22E,26E)-3,7,11,15,19,23,27-heptamethyl-30-(naphthalen-1-ylamino)triaconta-6,10,14,18,22,26-hexaen-1-yl dihydrogen phosphate + dolichyl phosphate
?
-
-
-
-
?
(6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-3,7,11,15,19,23,27,31,35,39-decamethyl-42-(naphthalen-1-ylamino)dotetraconta-6,10,14,18,22,26,30,34,38-nonaen-1-yl dihydrogen phosphate + dolichyl phosphate
?
-
-
-
-
?
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
GDP-alpha-D-mannose + farnesyl phosphate
GDP + farnesyl beta-D-mannosyl phosphate
-
less efficient than dolichol phosphate
-
-
?
GDP-mannose + C110-dolichyl phosphate
GDP + C110-dolichyl D-mannosyl phosphate
-
-
-
-
?
GDP-mannose + C120-dolichyl phosphate
GDP + C120-dolichyl D-mannosyl phosphate
-
-
-
-
?
GDP-mannose + C55-undecaprenyl phosphate
GDP + C55-undecaprenyl D-mannosyl phosphate
-
-
-
-
?
GDP-mannose + C85-dolichyl phosphate
GDP + C85-dolichyl D-mannosyl phosphate
-
-
-
-
?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
GDPmannose + (S)-3-methyloctadecanyl phosphate
GDP + (S)-3-methyloctadecanyl D-mannosyl phosphate
-
-
-
-
?
GDPmannose + C100 alpha-dihydropolyprenyl phosphate
GDP + C100 alpha-dihydropolyprenyl D-mannosyl phosphate
-
-
-
-
?
GDPmannose + C55 alpha-dihydropolyprenyl phosphate
GDP + C55 alpha-dihydropolyprenyl D-mannosyl phosphate
-
-
-
-
?
GDPmannose + C55-polyisoprenol
GDP + D-mannosyl-C55-polyisopropenol
-
-
-
-
?
GDPmannose + C80 alpha-dihydropolyprenyl phosphate
GDP + C80 alpha-dihydropolyprenyl D-mannosyl phosphate
-
-
-
-
?
GDPmannose + cetyl phosphate
GDP + cetyl D-mannosyl phosphate
-
less efficient than dolichol phosphate
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
GDPmannose + phytanyl phosphate
GDP + phytanyl D-mannosyl phosphate
-
at 60-70% of the activity with dolichyl phosphate
-
-
?
additional information
?
-
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
-
-
-
?
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
GDP-alpha-D-mannose binding structure analysis, overview
-
-
?
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
-
-
-
?
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
GDP-alpha-D-mannose binding structure analysis, overview
-
-
?
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
-
-
-
?
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
GDP-alpha-D-mannose binding structure analysis, overview
-
-
?
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
-
-
-
?
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
GDP-alpha-D-mannose binding structure analysis, overview
-
-
?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
-
?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
-
?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
-
?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
-
?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
cAMP-dependent protein kinase is essential for upregulating the Dol-P-Man synthase activity and consequently the Glc3Man9GlcNAc-PP-Dol biosymthesis and protein N-glycosylation in cAMP-responsive cells
-
-
?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
-
?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
the enzyme transfers mannose from the water soluble cytoplasmic donor GDP-Man, to the membrane bound, extremely hydrophobic, and long-chain polyisoprenoid acceptor, dolichyl-phosphate
-
-
?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
or synthetic analogs of dolichyl phosphate
-
-
?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
-
?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
r
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
essential enzyme in glycoprotein biosynthesis
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
cAMP-mediated protein phosphorylation of microsomal membranes increases mannosylphosphodolichol synthase activity
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
the enzyme is involved in glycoconjugate biosynthesis
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
synthesis of dolichol-phosphate mannose, a key mannosyl donor for the biosynthesis of N-linked oligosaccharides as well as for O-linked oligosaccharides on yeast glycoproteins
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
r
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
additional information
?
-
-
two binding proteins, DPMS2 and DPMS3 serve as membrane anchors for DPMS1 or provide catalytic assistance. Recombinant DPMS1 alone does not catalyze dolichyl D-mannosyl phosphate synthesis
-
-
?
additional information
?
-
-
activities of fluorescent labeled dolichyl-phosphate derivatives
-
-
?
additional information
?
-
-
branching of lipid phosphates is essential for substrates of the enzyme, transfer of mannose occurs even if only branching at C3 is present
-
-
?
additional information
?
-
-
increased availability of GDP-mannose corrects glycosylation defects in the endoplasmic reticulum, such as dolichyl D-mannosyl phosphate formation in dolichyl-phosphate beta-D-mannosyltransferase mutants of Saccharomyces cerevisiae
-
-
?
additional information
?
-
-
glycosylphosphatidylinositol anchor biosynthesis
-
-
?
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evolution
PfDPMS is a membrane enzymes of the GT2 family. All known bona fide DPMSs use GDP-Man as donor substrate. Proposed model of substrate binding and product release
evolution
-
PfDPMS is a membrane enzymes of the GT2 family. All known bona fide DPMSs use GDP-Man as donor substrate. Proposed model of substrate binding and product release
-
evolution
-
PfDPMS is a membrane enzymes of the GT2 family. All known bona fide DPMSs use GDP-Man as donor substrate. Proposed model of substrate binding and product release
-
evolution
-
PfDPMS is a membrane enzymes of the GT2 family. All known bona fide DPMSs use GDP-Man as donor substrate. Proposed model of substrate binding and product release
-
malfunction
-
loss-of-function mutations and RNA interference-mediated reduction of DPMS1 expression in Arabidopsis causes a wrinkled seed coat phenotype and most remarkably enhanced hypersensitivity to ammonium that is manifested by extensive chlorosis and a strong reduction of root growth
malfunction
failure to produce or utilize dolichyl mannosyl phosphate compromises organism viability
malfunction
-
failure to produce or utilize dolichyl mannosyl phosphate compromises organism viability
-
malfunction
-
failure to produce or utilize dolichyl mannosyl phosphate compromises organism viability
-
malfunction
-
failure to produce or utilize dolichyl mannosyl phosphate compromises organism viability
-
metabolism
-
dolichyl phosphate mannose synthase is a key enzyme in the O-glycosylation pathway
metabolism
the enzyme is involved in dolichylphosphate mannose biosynthesis
metabolism
-
the enzyme is involved in dolichylphosphate mannose biosynthesis
-
metabolism
-
the enzyme is involved in dolichylphosphate mannose biosynthesis
-
metabolism
-
the enzyme is involved in dolichylphosphate mannose biosynthesis
-
physiological function
-
high level of expression of (GlcNAc-beta-(1,4)-GlcNAc) 1-4-beta-GlcNAc-NeuAc glycans on the external surface of the capillary endothelial cells overexpressing DPMS. Increased cellular proliferation and accelerated healing of the wound induced by mechanical stress of the DPMS-overexpressing clone unequivocally supports a role of DPMS in angiogenesis
physiological function
-
overexpression of DPMS accelerates angiogenesis, a higher rate of cellular proliferation in DPMS overexpressing cells compared to the pEGFP-N1 vector and the parental cells
physiological function
-
elevated activity of overexpressed Saccharomyces cerevisiae dolichyl phosphate mannose synthase enhances biocontrol abilities of Trichoderma atroviride
physiological function
-
overexpression of DPMS1 in Arabidopsis thaliana results in disorganized stem morphology and vascular bundle arrangements, wrinkled seed coat, and constitutive ER stress response
physiological function
subunits Dpm1 and Dpm3 function as host dependency factors for Dengue virus and other related flaviviruses such as Zika virus. Mutation in the DXD motif of Dpm1, which is essential for its catalytic activity, abolishes DPMS-mediated Dengue virus infection. Genetic ablation of mannosyltransferase ALG3 renders cells poorly susceptible to Dengue virus. In cells deficient for DPMS activity, viral RNA amplification is hampered and truncated oligosaccharides are transferred to the viral precursor of the M protein and E glycoproteins, affecting their proper folding
physiological function
transient depletion of the Dpm genes, the resulting morphant embryos show early death, muscle disorganization, low dolichol-phosphate mannose synthase complex activity, and increased levels of apoptotic nuclei, together with hypoglycosylated alpha-dystroglycan in muscle fibers
physiological function
the membrane protein dolichylphosphate mannose synthase (DPMS) catalyzes the reaction whereby mannose is transferred from GDP-mannose to the dolichol carrier dolichyl phosphate (Dol-P), to yield dolichyl mannosyl phosphate (Dol-P-Man). Lipid binding couples to movements of interface helices, metal binding, and acceptor loop dynamics to control critical events leading to Dol-P-Man synthesis
physiological function
-
the membrane protein dolichylphosphate mannose synthase (DPMS) catalyzes the reaction whereby mannose is transferred from GDP-mannose to the dolichol carrier dolichyl phosphate (Dol-P), to yield dolichyl mannosyl phosphate (Dol-P-Man). Lipid binding couples to movements of interface helices, metal binding, and acceptor loop dynamics to control critical events leading to Dol-P-Man synthesis
-
physiological function
-
the membrane protein dolichylphosphate mannose synthase (DPMS) catalyzes the reaction whereby mannose is transferred from GDP-mannose to the dolichol carrier dolichyl phosphate (Dol-P), to yield dolichyl mannosyl phosphate (Dol-P-Man). Lipid binding couples to movements of interface helices, metal binding, and acceptor loop dynamics to control critical events leading to Dol-P-Man synthesis
-
physiological function
-
the membrane protein dolichylphosphate mannose synthase (DPMS) catalyzes the reaction whereby mannose is transferred from GDP-mannose to the dolichol carrier dolichyl phosphate (Dol-P), to yield dolichyl mannosyl phosphate (Dol-P-Man). Lipid binding couples to movements of interface helices, metal binding, and acceptor loop dynamics to control critical events leading to Dol-P-Man synthesis
-
additional information
structure-function analysis, and structural comparison with related enzymes, detailed overview. The IF helices IFH1 and IFH2 are important for activity
additional information
-
structure-function analysis, and structural comparison with related enzymes, detailed overview. The IF helices IFH1 and IFH2 are important for activity
additional information
-
structure-function analysis, and structural comparison with related enzymes, detailed overview. The IF helices IFH1 and IFH2 are important for activity
-
additional information
-
structure-function analysis, and structural comparison with related enzymes, detailed overview. The IF helices IFH1 and IFH2 are important for activity
-
additional information
-
structure-function analysis, and structural comparison with related enzymes, detailed overview. The IF helices IFH1 and IFH2 are important for activity
-
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Riedell, W.E.; Miernyk, J.A.
Glycoprotein synthesis in maize endosperm cells. The nucleoside diphosphate-sugar:dolichol-phosphate glycosyltransferase
Plant Physiol.
87
420-426
1988
Zea mays
brenda
Babczinski, P.; Haselbeck, A.; Tanner, W.
Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and characterization of the solubilized enzyme
Eur. J. Biochem.
105
509-515
1980
Saccharomyces cerevisiae
brenda
Palamarczyk, G.; Lehle, L.; Mankowski, T.; Chojnacki, T.; Tanner, W.
Specificity of solubilized yeast glycosyl transferases for polyprenyl derivatives
Eur. J. Biochem.
105
517-523
1980
Saccharomyces cerevisiae
brenda
Haselbeck, A.
Purification of GDP mannose:dolichyl-phosphate O-beta-D-mannosyltransferase from Saccharomyces cerevisiae
Eur. J. Biochem.
181
663-668
1989
Saccharomyces cerevisiae
brenda
Bretthauer, R.K.; Wu, S.; Irwin, W.E.
Enzymatic transfer of mannose from guanosine diphosphate mannose to dolichol phosphate in yeast (Hansenula holstii). A possible step in mannan synthesis
Biochim. Biophys. Acta
304
736-747
1973
Nakazawaea holstii
brenda
Richards, J.B.; Hemming, F.W.
The transfer of mannose from guanosine diphosphate mannose to dolichol phosphate and protein by pig liver endoplasmic reticulum
Biochem. J.
130
77-93
1972
Sus scrofa
brenda
Jensen, J.W.; Schutzbach, J.S.
Characterization of mannosyl-transfer reactions catalyzed by dolichyl-mannosyl-phosphate-synthase
Carbohydr. Res.
149
199-208
1986
Rattus norvegicus
brenda
Jensen, J.W.; Schutzbach, J.S.
Activation of dolichyl-phospho-mannose synthase by phospholipids
Eur. J. Biochem.
153
41-48
1985
Rattus norvegicus
brenda
Gasnier, F.; Rousson, R.; Lerme, F.; Vaganay, E.; Louisot, P.; Gateau-Roesch, O.
Mitochondrial dolichyl-phosphate mannose synthase. Purification and immunogold localization by electron microscopy
Eur. J. Biochem.
206
853-858
1992
Mus musculus
brenda
Gasnier, F.; Louisot, P.; Gateau-Roesch, O.
Topological orientation of mitochondrial GDPmannose: dolichyl-monophosphate mannosyltransferase in the outer membrane
Biochim. Biophys. Acta
980
339-347
1989
Mus musculus
brenda
Kruszewska, J.; Palamarczyk, G.; Kubicek, C.P.
Mannosyl-phospho-dolichol synthase from Trichoderma reesei is activated by protein kinase dependent phosphorylation in vitro
FEMS Microbiol. Lett.
80
81-86
1991
Trichoderma reesei, Trichoderma reesei QM 9414
-
brenda
McDowell, W.; Schwarz, R.T.
Specificity of GDP-Man:dolichyl-phosphate mannosyltransferase for the guanosine diphosphate esters of mannose analogues containing deoxy and deoxyfluoro substituents
FEBS Lett.
243
413-416
1989
Gallus gallus
brenda
Gasnier, F.; Morelis, R.; Louisot, P.; Gateau, O.
Purification and properties of a mannosyltransferase solubilized from mitochondrial outer membranes
Biochim. Biophys. Acta
925
297-304
1987
Mus musculus
brenda
Tomita, Y.; Motokawa, Y.
GDPmannose dolicholphosphate mannosyltransferase of chicken liver mitochondria
Biochim. Biophys. Acta
842
176-183
1985
Gallus gallus
brenda
Carlo, P.L.; Villemez, C.L.
Solubilization and properties of polyprenyl phosphate: GDP-D-mannose mannosyl transferase
Arch. Biochem. Biophys.
198
117-123
1979
Acanthamoeba castellanii
brenda
Wilson, I.B.H.; Taylor, J.P.; Webberley, M.C.; Turner, N.J.; Flitsch, S.L.
A novel mono-branched lipid phosphate acts as a substrate for dolichyl phosphate mannose synthetase
Biochem. J.
295
195-201
1993
Saccharomyces cerevisiae
-
brenda
Schutzbach, J.S.; Zimmerman, J.W.; Forsee, W.T.
The purification and characterization of recombinant yeast dolichyl-phosphate-mannose synthase. Site-directed mutagenesis of the putative dolichol recognition sequence
J. Biol. Chem.
268
24190-24196
1993
Saccharomyces cerevisiae
brenda
Banerjee, D.K.; Kousvelari, E.E.; Baum, B.J.
cAMP-mediated protein phosphorylation of microsomal membranes increases mannosylphosphodolichol synthase activity
Proc. Natl. Acad. Sci. USA
84
6389-6393
1987
Rattus norvegicus
brenda
Colussi, P.A.; Taron, C.H.; Mack, J.C.; Orlean, P.
Human and Saccharomyces cerevisiae dolichol phosphate mannose synthases represent two classes of the enzyme, but both function in Schizosaccharomyces pombe
Proc. Natl. Acad. Sci. USA
94
7873-7878
1997
Saccharomyces cerevisiae, Homo sapiens (O60762), Homo sapiens
brenda
Maeda, Y.; Tanaka, S.; Hino, J.; Kangawa, K.; Kinoshita, T.
Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3
EMBO J.
19
2475-2482
2000
Homo sapiens
brenda
Xing, J.; Forsee, W.T.; Lamani, E.; Maltsev, S.D.; Danilov, L.L.; Shibaev, V.N.; Schutzbach, J.S.; Cheung, H.C.; Jedrzejas, M.J.
Investigations of the active site of Saccharomyces cerevisiae dolichyl-phosphate-mannose synthase using fluorescent labeled dolichyl-phosphate derivatives
Biochemistry
39
7886-7894
2000
Saccharomyces cerevisiae
brenda
Villagomez-Castro, J.C.; Calvo-Mendez, C.; Flores-Carreon, A.; Lopez-Romero, E.
Partial purification and characterization of dolichol phosphate mannose synthase from Entamoeba histolytica
Glycobiology
10
1311-1316
2000
Entamoeba histolytica
brenda
Tempone, A.J.; Furtado, D.R.; Gimba, E.R.T.; Oliveira, F.M.B.; Rumjanek, F.D.
Dolichol phosphate mannose synthase is differentially expressed in male and female worms of Schistosoma mansoni
Comp. Biochem. Physiol. B
131B
465-474
2002
Schistosoma mansoni
-
brenda
Zimmerman, J.W.; Robbins, P.W.
The hydrophobic domain of dolichyl-phosphate-mannose synthase is not essential for enzyme activity or growth in Saccharomyces cerevisiae
J. Biol. Chem.
268
16746-16753
1993
Saccharomyces cerevisiae
brenda
Mazhari-Tabrizi, R.; Eckert, V.; Blank, M.; Mueller, R.; Mumberg, D.; Funk, M.; Schwarz, R.T.
Cloning and functional expression of glycosyltransferases from parasitic protozoans by heterologous complementation in yeast: the dolichol phosphate mannose synthase from Trypanosoma brucei brucei
Biochem. J.
316
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