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Disease on EC 2.4.99.6 - N-acetyllactosaminide alpha-2,3-sialyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Habitual
Expression of the Carbohydrate Lewis Antigen, Sialyl Lewis A, Sialyl Lewis X, Lewis X, and Lewis Y in the Placental Villi of Patients With Unexplained Miscarriages.
Abortion, Spontaneous
Expression of the Carbohydrate Lewis Antigen, Sialyl Lewis A, Sialyl Lewis X, Lewis X, and Lewis Y in the Placental Villi of Patients With Unexplained Miscarriages.
Adenocarcinoma
?2,3-sialyltransferase ST3Gal IV promotes migration and metastasis in pancreatic adenocarcinoma cells and tends to be highly expressed in pancreatic adenocarcinoma tissues.
alpha2,3-sialyltransferase ST3Gal III modulates pancreatic cancer cell motility and adhesion in vitro and enhances its metastatic potential in vivo.
Knockdown of ?2,3-Sialyltransferases Impairs Pancreatic Cancer Cell Migration, Invasion and E-selectin-Dependent Adhesion.
Pancreatic cancer cell glycosylation regulates cell adhesion and invasion through the modulation of ?2?1 integrin and E-cadherin function.
ST3Gal IV Mediates the Growth and Proliferation of Cervical Cancer Cells In Vitro and In Vivo Via the Notch/p21/CDKs Pathway.
Autoimmune Diseases
The expanding role of ?2-3 sialylation for leukocyte trafficking in vivo.
Breast Neoplasms
Multiplex reverse transcription polymerase chain reaction assessment of sialyltransferase expression in human breast cancer.
Prognostic value of tumoral sialyltransferase expression and circulating E-selectin concentrations in node-negative breast cancer patients.
Regulation of sialyltransferase expression by estradiol and 4-OH-tamoxifen in the human breast cancer cell MCF-7.
ST3Gal III modulates breast cancer cell adhesion and invasion by altering the expression of invasion-related molecules.
ST3Gal IV Mediates the Growth and Proliferation of Cervical Cancer Cells In Vitro and In Vivo Via the Notch/p21/CDKs Pathway.
Carcinogenesis
Glycosyltransferase expression in human colonic tissue examined by oligonucleotide arrays.
Carcinoma
"Aberrant sialylation plays a significant role in oral squamous cell carcinoma progression".
Altered mRNA expression of glycosyltransferases in human colorectal carcinomas and liver metastases.
Altered mRNA expression of glycosyltransferases in human gastric carcinomas.
Altered mRNA expression of sialyltransferase in squamous cell carcinomas of the cervix.
Carcinoembryonic antigen carrying SLeX as a new biomarker of more aggressive gastric carcinomas.
Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line.
Clinical significance of ST3Gal IV expression in human renal cell carcinoma.
Cloning and expression of SAT-3 involved in SA-Le(x) biosynthesis: inhibition studies with polyclonal antibody against GST-SAT-3 fusion protein.
DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer.
Expression of sialyltransferase family members in cervix squamous cell carcinoma correlates with lymph node metastasis.
Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells.
ST3Gal IV Mediates the Growth and Proliferation of Cervical Cancer Cells In Vitro and In Vivo Via the Notch/p21/CDKs Pathway.
Up-regulation of a set of glycosyltransferase genes in human colorectal cancer.
Carcinoma, Hepatocellular
Differences in CD75s- and iso-CD75s-ganglioside content and altered mRNA expression of sialyltransferases ST6GAL1 and ST3GAL6 in human hepatocellular carcinomas and nontumoral liver tissues.
Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene.
Sialyltransferase ST3GAL6 mediates the effect of microRNA-26a on cell growth, migration, and invasion in hepatocellular carcinoma through the protein kinase B/mammalian target of rapamycin pathway.
Carcinoma, Renal Cell
Clinical significance of ST3Gal IV expression in human renal cell carcinoma.
Carcinoma, Squamous Cell
Altered mRNA expression of sialyltransferase in squamous cell carcinomas of the cervix.
Expression of sialyltransferase family members in cervix squamous cell carcinoma correlates with lymph node metastasis.
Colorectal Neoplasms
Sialyltransferase activity and hepatic tumor growth in a nude mouse model of colorectal cancer metastases.
Up-regulation of a set of glycosyltransferase genes in human colorectal cancer.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
A novel nonsense and inactivating variant of ST3GAL3 in two infant siblings suffering severe epilepsy and expressing circulating CA19.9.
Epilepsy
A novel nonsense and inactivating variant of ST3GAL3 in two infant siblings suffering severe epilepsy and expressing circulating CA19.9.
Congenital Disorders of Glycosylation from a Neurological Perspective.
Phenotype of ST3GAL3 deficient patients: A case and review of the literature.
Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy.
Epilepsy, Temporal Lobe
Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy.
Hypertension, Pulmonary
Multiplex reverse transcription polymerase chain reaction assessment of sialyltransferase expression in peripheral blood mononuclear cells in systemic sclerosis.
Influenza in Birds
The expression pattern and histological distribution of sialyltransferases ST3Gal III in yellow chicken.
Intellectual Disability
A novel variant of ST3GAL3 causes non-syndromic autosomal recessive intellectual disability in Iranian patients.
Phenotype of ST3GAL3 deficient patients: A case and review of the literature.
ST3GAL3 mutations impair the development of higher cognitive functions.
Leukemia
UDP-GlcNAc:Galbeta1-->3GalNAc (GlcNAc to GalNAc) beta1-->6N-acetylglucosaminyltransferase holds a key role on the control of CD15s expression in human pre-B lymphoid cell lines.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Downregulation of miR-224 and let-7i contribute to cell survival and chemoresistance in chronic myeloid leukemia cells by regulating ST3GAL IV expression.
Lymphatic Metastasis
Expression of sialyltransferase family members in cervix squamous cell carcinoma correlates with lymph node metastasis.
Melanoma
Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line.
Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids.
Mouth Neoplasms
"Aberrant sialylation plays a significant role in oral squamous cell carcinoma progression".
Multiple Myeloma
lncRNA ST3GAL6?AS1 promotes invasion by inhibiting hnRNPA2B1?mediated ST3GAL6 expression in multiple myeloma.
Targeting Selectins and Their Ligands in Cancer.
The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma.
n-acetyllactosaminide alpha-2,3-sialyltransferase deficiency
A patient-specific induced pluripotent stem cell model for West syndrome caused by ST3GAL3 deficiency.
Phenotype of ST3GAL3 deficient patients: A case and review of the literature.
Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands.
The sialyltransferase ST3Gal-IV guides murine T-cell progenitors to the thymus.
West syndrome caused by ST3Gal-III deficiency.
Neoplasm Metastasis
"Aberrant sialylation plays a significant role in oral squamous cell carcinoma progression".
?2,3-sialyltransferase ST3Gal IV promotes migration and metastasis in pancreatic adenocarcinoma cells and tends to be highly expressed in pancreatic adenocarcinoma tissues.
alpha2,3-sialyltransferase ST3Gal III modulates pancreatic cancer cell motility and adhesion in vitro and enhances its metastatic potential in vivo.
Correlation of glycosyltransferases mRNA expression in extrahepatic bile duct carcinoma with clinical pathological characteristics.
Expression of sialyltransferase family members in cervix squamous cell carcinoma correlates with lymph node metastasis.
Glycosyltransferase expression in human colonic tissue examined by oligonucleotide arrays.
Knockdown of ?2,3-Sialyltransferases Impairs Pancreatic Cancer Cell Migration, Invasion and E-selectin-Dependent Adhesion.
Neoplasms
?2,3-sialyltransferase ST3Gal IV promotes migration and metastasis in pancreatic adenocarcinoma cells and tends to be highly expressed in pancreatic adenocarcinoma tissues.
Alpha2,3-sialyltransferase III knockdown sensitized ovarian cancer cells to cisplatin-induced apoptosis.
alpha2,3-sialyltransferase ST3Gal III modulates pancreatic cancer cell motility and adhesion in vitro and enhances its metastatic potential in vivo.
Altered mRNA expression of glycosyltransferases in human colorectal carcinomas and liver metastases.
Clinical relevance of sialyltransferases ST6GAL-I and ST3GAL-III in gastric cancer.
Clinical significance of ST3Gal IV expression in human renal cell carcinoma.
Correlation between Heterogeneous Expression of Sialyltransferases and MUC16 in Ovarian Tumor Tissues.
Correlation of glycosyltransferases mRNA expression in extrahepatic bile duct carcinoma with clinical pathological characteristics.
Differences in CD75s- and iso-CD75s-ganglioside content and altered mRNA expression of sialyltransferases ST6GAL1 and ST3GAL6 in human hepatocellular carcinomas and nontumoral liver tissues.
Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells.
Glycosyltransferases as marker genes for the quantitative polymerase chain reaction-based detection of circulating tumour cells from blood samples of patients with breast cancer undergoing adjuvant therapy.
Hypoxia and serum deprivation induces glycan alterations in triple negative breast cancer cells.
Identification of glycogene-type and validation of ST3GAL6 as a biomarker predicts clinical outcome and cancer cell invasion in urinary bladder cancer.
LncRNA ST3Gal6-AS1/ST3Gal6 axis mediates colorectal cancer progression by regulating ?-2,3 sialylation via PI3K/Akt signaling.
Multiplex reverse transcription polymerase chain reaction assessment of sialyltransferase expression in human breast cancer.
Pancreatic cancer cell glycosylation regulates cell adhesion and invasion through the modulation of ?2?1 integrin and E-cadherin function.
Prognostic value of tumoral sialyltransferase expression and circulating E-selectin concentrations in node-negative breast cancer patients.
Pseudomonas aeruginosa pyocyanin modulates mucin glycosylation with sialyl-Lewis(x) to increase binding to airway epithelial cells.
Sialyltransferase ST3GAL6 mediates the effect of microRNA-26a on cell growth, migration, and invasion in hepatocellular carcinoma through the protein kinase B/mammalian target of rapamycin pathway.
Siglec1-expressing subcapsular sinus macrophages provide soil for melanoma lymph node metastasis.
Targeting Selectins and Their Ligands in Cancer.
The expanding role of ?2-3 sialylation for leukocyte trafficking in vivo.
The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.
The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma.
Unexpected distribution of CA19.9 and other type 1 chain Lewis antigens in normal and cancer tissues of colon and pancreas: Importance of the detection method and role of glycosyltransferase regulation.
Ovarian Neoplasms
Alpha2,3-sialyltransferase III knockdown sensitized ovarian cancer cells to cisplatin-induced apoptosis.
Altered mRNA expressions of sialyltransferases in ovarian cancers.
Correlation between Heterogeneous Expression of Sialyltransferases and MUC16 in Ovarian Tumor Tissues.
ST3Gal3 confers paclitaxel?mediated chemoresistance in ovarian cancer cells by attenuating caspase?8/3 signaling.
Pancreatic Neoplasms
alpha2,3-sialyltransferase ST3Gal III modulates pancreatic cancer cell motility and adhesion in vitro and enhances its metastatic potential in vivo.
Pneumonia
Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice.
Prostatic Neoplasms
Analysis of the specificity of sialyltransferases toward mucin core 2, globo, and related structures. identification of the sialylation sequence and the effects of sulfate, fucose, methyl, and fluoro substituents of the carbohydrate chain in the biosynthesis of selectin and siglec ligands, and novel sialylation by cloned alpha2,3(O)sialyltransferase.
Pterygium
Alteration of sialyl Lewis epitope expression in pterygium.
Seizures
Differential expression of mRNAs for sialyltransferase isoenzymes induced in the hippocampus of mouse following kindled seizures.
Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy.
Spasms, Infantile
A patient-specific induced pluripotent stem cell model for West syndrome caused by ST3GAL3 deficiency.
West syndrome caused by ST3Gal-III deficiency.
Stomach Neoplasms
Altered mRNA expressions of sialyltransferases in human gastric cancer tissues.
Analysis of the Effect of Increased ?2,3-Sialylation on RTK Activation in MKN45 Gastric Cancer Spheroids Treated with Crizotinib.
Carcinoembryonic antigen carrying SLeX as a new biomarker of more aggressive gastric carcinomas.
Clinical relevance of sialyltransferases ST6GAL-I and ST3GAL-III in gastric cancer.
DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer.
Thrombocytopenia
Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands.
Urinary Bladder Neoplasms
Identification of glycogene-type and validation of ST3GAL6 as a biomarker predicts clinical outcome and cancer cell invasion in urinary bladder cancer.
Uterine Cervical Neoplasms
Altered mRNA expression of sialyltransferase in squamous cell carcinomas of the cervix.
Expression of sialyltransferase family members in cervix squamous cell carcinoma correlates with lymph node metastasis.
ST3Gal IV Mediates the Growth and Proliferation of Cervical Cancer Cells In Vitro and In Vivo Via the Notch/p21/CDKs Pathway.