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1-acyl-glycerone 3-phosphate + a long-chain alcohol
an alkyl-glycerone 3-phosphate + a long-chain acid anion
1-acylglycerone 3-phosphate + long-chain alcohol
alkylglycerone 3-phosphate + long-chain acid anion + H+
1-O-hexadecyldihydroxyacetone phosphate + hexadecanol
long-chain acid anion + 1-O-hexadecyldihydroxyacetone phosphate
-
-
-
-
?
oleoyldihydroxyacetone phosphate + hexadecanol
oleate + 1-O-hexadecyldihydroxyacetone phosphate
-
-
-
-
?
palmitoyldihydroxyacetone phosphate + hexadecanol
1-O-hexadecyldihydroxyacetone phosphate + palmitate
palmitoyldihydroxyacetone phosphate + octadecanol
palmitate + 1-O-octadecyldihydroxyacetone phosphate
stearoyldihydroxyacetone phosphate + hexadecanol
stearate + 1-O-hexadecyldihydroxyacetone phosphate
stearoyldihydroxyacetone phosphate + octadecanol
stearate + 1-O-octadecyldihydroxyacetone phosphate
-
-
-
-
?
additional information
additional information
-
1-acyl-glycerone 3-phosphate + a long-chain alcohol
an alkyl-glycerone 3-phosphate + a long-chain acid anion
-
-
-
-
?
1-acyl-glycerone 3-phosphate + a long-chain alcohol
an alkyl-glycerone 3-phosphate + a long-chain acid anion
-
-
-
-
?
1-acylglycerone 3-phosphate + long-chain alcohol
alkylglycerone 3-phosphate + long-chain acid anion + H+
-
-
-
-
?
1-acylglycerone 3-phosphate + long-chain alcohol
alkylglycerone 3-phosphate + long-chain acid anion + H+
-
1-acylglycerone 3-phosphate is acyldihydroxyacetone phosphate, the ester-linked fatty acid of the substrate is cleaved and replaced by a long-chain alcohol in the ether
-
?
1-acylglycerone 3-phosphate + long-chain alcohol
alkylglycerone 3-phosphate + long-chain acid anion + H+
-
forms the ether bond found in alkyl and alk-1-enyl glycerolipids
-
-
?
1-acylglycerone 3-phosphate + long-chain alcohol
alkylglycerone 3-phosphate + long-chain acid anion + H+
-
first committed step in biosynthesis of ether-linked glycerolipids
-
-
?
1-acylglycerone 3-phosphate + long-chain alcohol
alkylglycerone 3-phosphate + long-chain acid anion + H+
-
2 separate alkylglycerone-phosphate synthases, one in microsomes and another in peroxisomes might be engaged in biosynthesis of 1-O-alkylglycerolipids in rat liver
-
-
?
palmitoyldihydroxyacetone phosphate + hexadecanol
1-O-hexadecyldihydroxyacetone phosphate + palmitate
-
-
-
-
?
palmitoyldihydroxyacetone phosphate + hexadecanol
1-O-hexadecyldihydroxyacetone phosphate + palmitate
-
-
-
ir
palmitoyldihydroxyacetone phosphate + hexadecanol
1-O-hexadecyldihydroxyacetone phosphate + palmitate
-
-
-
-
?
palmitoyldihydroxyacetone phosphate + hexadecanol
1-O-hexadecyldihydroxyacetone phosphate + palmitate
-
-
-
?
palmitoyldihydroxyacetone phosphate + hexadecanol
1-O-hexadecyldihydroxyacetone phosphate + palmitate
-
-
-
-
?
palmitoyldihydroxyacetone phosphate + octadecanol
palmitate + 1-O-octadecyldihydroxyacetone phosphate
-
-
-
-
?
palmitoyldihydroxyacetone phosphate + octadecanol
palmitate + 1-O-octadecyldihydroxyacetone phosphate
-
-
-
-
?
palmitoyldihydroxyacetone phosphate + octadecanol
palmitate + 1-O-octadecyldihydroxyacetone phosphate
-
-
-
-
?
palmitoyldihydroxyacetone phosphate + octadecanol
palmitate + 1-O-octadecyldihydroxyacetone phosphate
-
-
-
?
stearoyldihydroxyacetone phosphate + hexadecanol
stearate + 1-O-hexadecyldihydroxyacetone phosphate
-
-
-
-
?
stearoyldihydroxyacetone phosphate + hexadecanol
stearate + 1-O-hexadecyldihydroxyacetone phosphate
-
-
-
?
additional information
additional information
-
-
overview on substrate specificity
-
-
?
additional information
additional information
-
-
overview on substrate specificity
-
-
?
additional information
additional information
-
-
-
-
-
?
additional information
additional information
-
-
specific for acyldihydroxyacetone phosphate, acyldihydroxyacetone or 1-acyl-sn-glycerol 3-phosphate cannot substitute for acyldihydroxyacetone phosphate, the acyl group chain length in acyldihydroxyacetone phosphate should be C12 or longer
-
-
?
additional information
additional information
-
-
alkyldihydroxyacetone phosphate synthase also catalyzes the following reactions: 1. acyl exchange reaction in which palmitic acid is incorporated into palmitoyldihydroxyacetone phosphate, 2. alkyl exchange reaction in which hexadecanol is incorporated into hexadecyldihydroxyacetone phosphate
-
-
?
additional information
additional information
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-
-
two reaction products: alkylglycerone phosphate and alkylglycerone, alkylglycerone phosphate is mainly synthesized by the peroxisomal synthase, whereas the inverse proportion is observed with the microsomal enzyme
?
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alkylglycerone-phosphate synthase deficiency
Alkyl-dihydroxyacetonephosphate synthase.
alkylglycerone-phosphate synthase deficiency
Human alkyldihydroxyacetonephosphate synthase deficiency: a new peroxisomal disorder.
Alzheimer Disease
Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease.
Breast Neoplasms
Computer-aided drug design and inhibitive effect of a novel nitrogenous heterocyclic compound and its mechanism on glioma U251 cells and breast cancer MCF-7 cells.
Carcinoma
Alkylglyceronephosphate synthase (AGPS) alters lipid signaling pathways and supports chemotherapy resistance of glioma and hepatic carcinoma cell lines.
Carcinoma
Role and mechanism of the alkylglycerone phosphate synthase in suppressing the invasion potential of human glioma and hepatic carcinoma cells in vitro.
Chondrodysplasia Punctata, Rhizomelic
Ether lipid biosynthesis: alkyl-dihydroxyacetonephosphate synthase protein deficiency leads to reduced dihydroxyacetonephosphate acyltransferase activities.
Chondrodysplasia Punctata, Rhizomelic
Immunological analyses of alkyl-dihydroxyacetone-phosphate synthase in human peroxisomal disorders.
Chondrodysplasia Punctata, Rhizomelic
Stability of alkyl-dihydroxyacetonephosphate synthase in human control and peroxisomal disorder fibroblasts.
Chondrodysplasia Punctata, Rhizomelic
The crucial step in ether phospholipid biosynthesis: structural basis of a noncanonical reaction associated with a peroxisomal disorder.
Glioma
Alkylglyceronephosphate synthase (AGPS) alters lipid signaling pathways and supports chemotherapy resistance of glioma and hepatic carcinoma cell lines.
Glioma
Computer-aided drug design and inhibitive effect of a novel nitrogenous heterocyclic compound and its mechanism on glioma U251 cells and breast cancer MCF-7 cells.
Glioma
Effect of alkylglycerone phosphate synthase on the expression levels of lncRNAs in glioma cells and its functional prediction.
Glioma
Role and mechanism of the alkylglycerone phosphate synthase in suppressing the invasion potential of human glioma and hepatic carcinoma cells in vitro.
Glioma
The effect of benzyl isothiocyanate and its computer-aided design derivants targeting alkylglycerone phosphate synthase on the inhibition of human glioma U87MG cell line.
Glioma
Tudor-staphylococcal nuclease regulates the expression and biological function of alkylglycerone phosphate synthase via nuclear factor-?B and microRNA-127 in human glioma U87MG cells.
Infections
The pathogenic white-rot fungus Heterobasidion parviporum triggers non-specific defence responses in the bark of Norway spruce.
Motor Neuron Disease
Nuclear lipidome is altered in amyotrophic lateral sclerosis: A pilot study.
Neoplasms
Alkylglyceronephosphate synthase (AGPS) alters lipid signaling pathways and supports chemotherapy resistance of glioma and hepatic carcinoma cell lines.
Neoplasms
Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells.
Neoplasms
Effect of alkylglycerone phosphate synthase on the expression levels of lncRNAs in glioma cells and its functional prediction.
Neoplasms
Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity.
Neoplasms
Inhibitory effect of isothiocyanate derivant targeting AGPS by computer-aid drug design on proliferation of glioma and hepatic carcinoma cells.
Neoplasms
Role and mechanism of the alkylglycerone phosphate synthase in suppressing the invasion potential of human glioma and hepatic carcinoma cells in vitro.
Neoplasms
Tudor-staphylococcal nuclease regulates the expression and biological function of alkylglycerone phosphate synthase via nuclear factor-?B and microRNA-127 in human glioma U87MG cells.
Peroxisomal Disorders
Alkyl-dihydroxyacetonephosphate synthase. Fate in peroxisome biogenesis disorders and identification of the point mutation underlying a single enzyme deficiency.
Peroxisomal Disorders
Human alkyldihydroxyacetonephosphate synthase deficiency: a new peroxisomal disorder.
Peroxisomal Disorders
Immunological analyses of alkyl-dihydroxyacetone-phosphate synthase in human peroxisomal disorders.
Peroxisomal Disorders
Immunological localization and tissue distribution of alkyldihydroxyacetonephosphate synthase and deficiency of the enzyme in peroxisomal disorders.
Peroxisomal Disorders
Stability of alkyl-dihydroxyacetonephosphate synthase in human control and peroxisomal disorder fibroblasts.
Peroxisomal Disorders
The crucial step in ether phospholipid biosynthesis: structural basis of a noncanonical reaction associated with a peroxisomal disorder.
Protein Deficiency
Ether lipid biosynthesis: alkyl-dihydroxyacetonephosphate synthase protein deficiency leads to reduced dihydroxyacetonephosphate acyltransferase activities.
Refsum Disease, Infantile
Infantile Refsum disease: deficiency of catalase-containing particles (peroxisomes), alkyldihydroxyacetone phosphate synthase and peroxisomal beta-oxidation enzyme proteins.
Thyroid Neoplasms
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.
Tuberculosis
A single amino acid substitution uncouples catalysis and allostery in an essential biosynthetic enzyme in Mycobacterium tuberculosis.
Tuberculosis
DAHP synthase from Mycobacterium tuberculosis H37Rv: cloning, expression, and purification of functional enzyme.
Tuberculosis
Evolving the naturally compromised chorismate mutase from Mycobacterium tuberculosis to top performance.
Tuberculosis
Inhibition of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis: in silico screening and in vitro validation.
Tuberculosis
The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes.
Zellweger Syndrome
Alkyl dihydroxyacetone phosphate synthase in human fibroblasts and its deficiency in Zellweger syndrome.
Zellweger Syndrome
Defective lipid remodeling of GPI anchors in peroxisomal disorders, Zellweger syndrome, and rhizomelic chondrodysplasia punctata.
Zellweger Syndrome
Immunological analyses of alkyl-dihydroxyacetone-phosphate synthase in human peroxisomal disorders.
Zellweger Syndrome
Isolation of animal cell mutants deficient in plasmalogen biosynthesis and peroxisome assembly.
Zellweger Syndrome
Properties of the enzymes catalyzing the biosynthesis of lysophosphatidate and its ether analog in cultured fibroblasts from Zellweger syndrome patients and normal controls.
Zellweger Syndrome
Stability of alkyl-dihydroxyacetonephosphate synthase in human control and peroxisomal disorder fibroblasts.
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malfunction
-
in plasmalogen-deficient Chinese hamster ovary mutant, ZPEG251, alkyl-dihydroxyacetonephosphate synthase, is defective. ADAPS mRNA is barely detectable by Northern blot and RT-PCR analyses. Defect of ADAPS expression is also assessed by immunoblot. Ectopic expression of ADAPS-EGFP, enhances the plasmalogen level
malfunction
-
AGPS protein level and phosphatidylethanolamine plasmalogen level are decreased in amyloid-beta protein precursor-deficient cells and brains, overview
malfunction
-
AGPS protein level and phosphatidylethanolamine plasmalogen level are decreased in amyloid-beta protein precursor-deficient cells and brains, overview
malfunction
cataracts and male infertility in blind sterile 2 (bs2) mice are caused by a spontaneous hypomorphic mutation in gene agp. Infertility in bs2 mice is due to the aberrant formation of multicellular cellular clusters that undergo apoptosis. The majority of Agps knock-out mice die embryonically. Correlations of RCDP3 and bs2 phenotypes, detailed overview
malfunction
knockdown of enzyme AGPS restores the drug sensitivity in glioma U-87MG/DDP and hepatic carcinoma Hep-G2/ADM cell lines. Silencing of AGPS leads to reduced cellular level of lysophosphatidic acid, lysophosphatidic acid-ether and prostaglandin E2, which can fuel aggressive and progress of cancer. Knockdown of AGPS also results in downregulation of multi-drug resistance proteins and anti-apoptosis proteins
malfunction
mutations in alkylglycerone phosphate synthase cause rhizomelic chondrodysplasia punctata, RCDP type 3 (RCDP3), a genetically heterogeneous autosomal recessive syndrome characterized by congenital cataracts, shortening of the proximal limbs, neurological abnormalities, seizures, growth delays, and severe intellectual disability. RCDP children die in the first decade of life due to respiratory complications, clinical phenotypes. Correlations of RCDP3 and bs2 phenotypes, detailed overview
malfunction
silencing of AGPS leads to reduced cellular level of lysophosphatidic acid, lysophosphatidic acid-ether and prostaglandin E2, which can fuel aggressive and progress of cancer. Effect of AGPS on adhesion, invasion and cell cycle of glioma and hepatic carcinoma cells, overview
malfunction
AGPS silencing suppresses the proliferation and migration potential of glioma U87MG cells, and suppresses the expression of the circular RNAs circ-ubiquitin-associated protein 2, circ-zinc finger protein 292 and circ-homeodomain-interacting protein kinase 3, and the long non-coding RNAs H19 imprinted maternally expressed transcript (non-protein coding), colon cancer-associated transcript 1 (non-protein coding) and hepatocellular carcinoma upregulated long non-coding RNA
malfunction
effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO are investigated using circRNAs microarray
malfunction
knockdown of alkylglycerone-phosphate synthase leads to an overall reduction of ether lipid levels, as well as oncogenic signaling molecules, such as LPAe, PAFe and eicosanoids
malfunction
knockdown of alkylglycerone-phosphate synthase leads to an overall reduction of ether lipid levels, as well as oncogenic signaling molecules, such as LPAe, PAFe and eicosanoids, and it shows lower tumor growth rates in xenograft mice
malfunction
-
cataracts and male infertility in blind sterile 2 (bs2) mice are caused by a spontaneous hypomorphic mutation in gene agp. Infertility in bs2 mice is due to the aberrant formation of multicellular cellular clusters that undergo apoptosis. The majority of Agps knock-out mice die embryonically. Correlations of RCDP3 and bs2 phenotypes, detailed overview
-
metabolism
-
alkyl-dihydroxyacetonephosphate-synthase, AGPS, is a rate limiting enzyme in plasmalogen synthesis, catalyzing the initial committed step in plasmalogen synthesis, phosphatidylethanolamine plasmalogen de novo synthesis, overview. Plasmalogens are major brain lipids
metabolism
-
alkyl-dihydroxyacetonephosphate-synthase, AGPS, is a rate limiting enzyme in plasmalogen synthesis, catalyzing the initial committed step in plasmalogen synthesis, phosphatidylethanolamine plasmalogen de novo synthesis, overview. Plasmalogens are major brain lipids
metabolism
NF-kappaB and miR-127 may be the mediators of Tudor-SN-regulated AGPS via the mTOR signaling pathway
metabolism
positive correlation between the expression of alkylglycerone phosphate synthase (AGPS) and the malignant phenotype of thyroid cancer cell lines is identified. The inactivation of AGPS is able to decrease the malignancy of cancer, and inhibits tumor growth and invasion. AGPS is able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity
physiological function
Vitis vinifera x Vitis vinifera
-
involved in aromatic amino acid metabolism
physiological function
-
involved in aromatic amino acid metabolism
physiological function
-
plasmalogens are decreased as a consequence of Alzheimer's disease and regulated by amyloid-beta precursor protein processing under physiological conditions. Under the pathological situation of Alzheimer's disease, increased amyloid-beta levels lead to increased reactive oxidative species production, reduced AGPS protein and plasmalogen level, overview. Alterations in amyloid precursor protein-dependent changes of AGPS expression result in reduced protein and plasmalogen levels
physiological function
enzyme AGPS negatively regulates the invasion potential of glioma and hepatic carcinoma cells by modulating the expression of relevant genes and activity of the MAPK pathway. The MAPK signaling pathway is an important cell signaling pathway, involved in the regulation of many fundamental cellular processes
physiological function
the enzyme catalyzes the critical step in ether lipid synthesis
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Hardeman, D.; Van den Bosch, H.
Rat liver dihydroxyacetone-phosphate acyltransferase: enzyme characteristics and localization studies
Biochim. Biophys. Acta
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1988
Rattus norvegicus
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Alkyldihydroxyacetone-P synthase. Solubilization, partial purification, new assay method, and evidence for a ping-pong mechanism
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Alkyldihydroxyacetonephosphate synthase
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Alkyldihydroxyacetonephosphate synthase from guinea pig liver peroxisomes
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Cavia porcellus
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Brown, A.J.; Snyder, F.
The mechanism of alkyldihydroxyacetone-P synthase. Formation of [3H]H2O from acyl[1-R-3H]dihydroxyacetone-P by purified alkyldihydroxyacetone-P synthase in the absence of acylhydrolase activity
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258
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Mus musculus
brenda
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Ether lipid synthesis: purification and identification of alkyl dihydroxyacetone phosphate synthase from guinea-pig liver
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1993
Bos taurus, Cavia porcellus, Homo sapiens, Pan troglodytes, Rattus norvegicus
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Rabert, U.; Vlkl, A.; Debuch, H.
Distribution of alkylglycerone-phosphate synthase in subcellular fractions of rat liver
Biol. Chem. Hoppe-Seyler
367
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Rattus norvegicus
brenda
Gunawan, J.; Rabert, U.; Vlkl, A.; Debuch, H.
Kinetic studies of alkyl-dihydroxyacetone-phosphate (alkyl-glycerone-phosphate) synthase in peroxisomes of rat liver
Biol. Chem. Hoppe-Seyler
371
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1990
Rattus norvegicus
brenda
Biermann, J.; Schoonderwoerd, K.; Hom, M.L.; Luthjens, L.H.; Van den Bosch, H.
The native molecular size of alkyl-dihydroxyacetonephosphate synthase and dihydroxyacetone phosphate acyltransferase
Biochim. Biophys. Acta
1393
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1998
Cavia porcellus
brenda
De Vet, E.C.J.M.; Van Den Bosch, H.
Characterization of recombinant guinea pig alkyl-dihydroxyacetonephosphate synthase expressed in Escherichia coli. Kinetics, chemical modification and mutagenesis
Biochim. Biophys. Acta
1436
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1999
Cavia porcellus
brenda
Van den Bosch, H.; de Vet, E.C.J.M.
Alkyl-dihydroxyacetonephosphate synthase
Biochim. Biophys. Acta
1348
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1997
Cavia porcellus, Homo sapiens, Mus musculus
brenda
Zomer, A.W.M.; Opperdoes, F.R.; van den Bosch, H.
Alkyl dihydroxyacetone phosphate synthase in glycosomes of Trypanosoma brucei
Biochim. Biophys. Acta
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1995
Trypanosoma brucei (O97157), Trypanosoma brucei
brenda
De Vet, E.C.J.M.; Van den Bosch, H.
Alkyl-dihydroxyacetonephosphate synthase
Cell Biochem. Biophys.
32
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2000
Caenorhabditis elegans, Cavia porcellus, Homo sapiens
-
brenda
Biermann, J.; Gootjes, J.; Wanders, R.J.A.; Van den Bosch, H.
Stability of alkyl-dihydroxyacetonephosphate synthase in human control and peroxisomal disorder fibroblasts
IUBMB Life
48
635-639
1999
Homo sapiens
brenda
De Vet, E.C.J.M.; Biermann, J.; Van Den Bosch, H.
Immunological localization and tissue distribution of alkyldihydroxyacetonephosphate synthase and deficiency of the enzyme in peroxisomal disorders
Eur. J. Biochem.
247
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1997
Cavia porcellus
brenda
De Vet, E.C.J.M.; Ijlst, L.; Oostheim, W.; Wanders, R.J.A.; Van Den Bosch, H.
Alkyl-dihydroxyacetonephosphate synthase. Fate in peroxisome biogenesis disorders and identification of the point mutation underlying a single enzyme deficiency
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273
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1998
Homo sapiens
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Biermann, J.; Just, W.W.; Wanders, R.J.A.; Van den Bosch, H.
Alkyl-dihydroxyacetone phosphate synthase and dihydroxyacetone phosphate acyltransferase form a protein complex in peroxisomes
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261
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1999
Cavia porcellus
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De Vet, E.C.J.M.; Hilkes, Y.H.A.; Fraaije, M.W.; Van den Bosch, H.
Alkyl-dihydroxyacetonephosphate synthase: Presence and role of flavin adenine dinucleotide
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275
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2000
Cavia porcellus
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Mueller, W.E.G.; Klemt, M.; Thakur, N.L.; Schroeder, H.C.; Aiello, A.; D'Esposito, M.; Menna, M.; Fattorusso, E.
Molecular/chemical ecology in sponges: evidence for an adaptive antibacterial response in Suberites domuncula
Mar. Biol.
144
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2004
Suberites domuncula
-
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Honsho, M.; Yagita, Y.; Kinoshita, N.; Fujiki, Y.
Isolation and characterization of mutant animal cell line defective in alkyl-dihydroxyacetonephosphate synthase: localization and transport of plasmalogens to post-Golgi compartments
Biochim. Biophys. Acta
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2008
Cricetulus griseus
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Battilana, J.; Costantini, L.; Emanuelli, F.; Sevini, F.; Segala, C.; Moser, S.; Velasco, R.; Versini, G.; Stella Grando, M.
The 1-deoxy-D: -xylulose 5-phosphate synthase gene co-localizes with a major QTL affecting monoterpene content in grapevine
Theor. Appl. Genet.
118
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2009
Vitis vinifera x Vitis vinifera, Vitis vinifera x Vitis riparia
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Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimers disease
J. Neurochem.
116
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2011
Homo sapiens, Mus musculus
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Zhu, Y.; Liu, X.J.; Yang, P.; Zhao, M.; Lv, L.X.; Zhang, G.D.; Wang, Q.; Zhang, L.
Alkylglyceronephosphate synthase (AGPS) alters lipid signaling pathways and supports chemotherapy resistance of glioma and hepatic carcinoma cell lines
Asian Pac. J. Cancer Prev.
15
3219-3226
2014
Homo sapiens (O00116)
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Liegel, R.P.; Ronchetti, A.; Sidjanin, D.J.
Alkylglycerone phosphate synthase (AGPS) deficient mice: models for rhizomelic chondrodysplasia punctate type 3 (RCDP3) malformation syndrome
Mol. Genet. Metab. Rep.
1
299-311
2014
Homo sapiens (O00116), Homo sapiens, Mus musculus (Q8C0I1), Mus musculus, Mus musculus C57/BL6J (Q8C0I1)
brenda
Zhu, Y.; Zhu, L.; Lu, L.; Zhang, L.; Zhang, G.; Wang, Q.; Yang, P.
Role and mechanism of the alkylglycerone phosphate synthase in suppressing the invasion potential of human glioma and hepatic carcinoma cells in vitro
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32
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2014
Homo sapiens (O00116), Homo sapiens
brenda
Zhang, Y.; Jia, J.; Li, Y.; Chen, Y.G.; Huang, H.; Qiao, Y.; Zhu, Y.
Tudor-staphylococcal nuclease regulates the expression and biological function of alkylglycerone phosphate synthase via nuclear factor-kappaB and microRNA-127 in human glioma U87MG cells
Oncol. Lett.
15
9553-9558
2018
Homo sapiens (O00116), Homo sapiens
brenda
Yang, B.; Li, X.; He, L.; Zhu, Y.
Computer-aided design of temozolomide derivatives based on alkylglycerone phosphate synthase structure with isothiocyanate and their pharmacokinetic/toxicity prediction and anti-tumor activity in vitro
Biomed. Rep.
8
235-240
2018
Dictyostelium discoideum (O96759)
brenda
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Development of alkyl glycerone phosphate synthase inhibitors Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells
Eur. J. Med. Chem.
163
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2019
Homo sapiens (O00116), Cavia porcellus (P97275)
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Hou, S.; Tan, J.; Yang, B.; He, L.; Zhu, Y.
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO
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15
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2018
Homo sapiens (O00116), Homo sapiens
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Zhu, Y.; Han, Y.; Ma, Y.; Yang, P.
ADME/toxicity prediction and antitumor activity of novel nitrogenous heterocyclic compounds designed by computer targeting of alkylglycerone phosphate synthase
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1431-1438
2018
Homo sapiens (O00116)
brenda