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Information on EC 2.5.1.52 - L-mimosine synthase for references in articles please use BRENDA:EC2.5.1.52
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EC Tree
IUBMB Comments Brings about the biosynthesis of L-mimosine in plants of the Mimosa and Leucaena genera. Not identical with EC 2.5.1.51, beta-pyrazolylalanine synthase.
The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
Synonyms
EC 4.2.99.15, O3-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl), synthase, L-mimosine,
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EC 4.2.99.15
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formerly
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O3-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl)
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synthase, L-mimosine
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O-acetyl-L-serine + 3,4-dihydroxypyridine = 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate
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aminopropanoyl-group transfer
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O3-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase
Brings about the biosynthesis of L-mimosine in plants of the Mimosa and Leucaena genera. Not identical with EC 2.5.1.51, beta-pyrazolylalanine synthase.
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O-succinyl-L-serine + 3,4-dihydroxypyridine
3-(3,4-dihydroxypyridin-1-yl)-L-alanine + succinate
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60% of the activity with O-acetylserine
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?
O-sulfo-L-serine + 3,4-dihydroxypyridine
3-(3,4-dihydroxypyridin-1-yl)-L-alanine + sulfate
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32% of the activity with O-acetyl-L-serine
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O3-acetyl-L-serine + 3,4-dihydroxypyridine
3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate
O3-acetyl-L-serine + 3-amino-1,2,4-triazole
3-(3-amino-1,2,4-triazol-1-yl)-L-alanine + acetate
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30% of the activity with 3,4-dihydroxypyridine
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O3-acetyl-L-serine + N-hydroxyurea
ureidoserine + acetate
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13% of the activity with 3,4-dihydroxypyridine
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O3-acetyl-L-serine + pyrazole
3-(pyrazol-1-yl)-L-alanine + acetate
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82% of the activity with 3,4-dihydroxypyridine
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additional information
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O3-acetyl-L-serine + 3,4-dihydroxypyridine
3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate
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i.e. L-mimosine
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O3-acetyl-L-serine + 3,4-dihydroxypyridine
3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate
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best substrates
i.e. L-mimosine
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O3-acetyl-L-serine + 3,4-dihydroxypyridine
3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate
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involved in biosynthesis of heterocyclic beta-substituted alanines, brings about the biosynthesis of L-mimosine
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additional information
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no activity with O-phospho-L-serine and L-Ser
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additional information
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no activity with O-phospho-L-serine and L-Ser
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additional information
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no activity with alpha,beta-diaminopropionic acid
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O3-acetyl-L-serine + 3,4-dihydroxypyridine
3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate
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involved in biosynthesis of heterocyclic beta-substituted alanines, brings about the biosynthesis of L-mimosine
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pyridoxal 5'-phosphate
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requirement, enzyme bound, 1 mol pyridoxal 5'-phosphate per mol subunit
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additional information
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no substrate inhibition
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5
3,4-dihydroxypyridine
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7.8
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reaction with 3,4-dihydroxypyridine
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brenda
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brenda
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cotyledons removed
brenda
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CYSK_CITLA
325
0
34343
Swiss-Prot
E4NKY0_HALBP
Halogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 / PR3)
340
0
36007
TrEMBL
D2Q947_BIFDB
Bifidobacterium dentium (strain ATCC 27534 / DSM 20436 / JCM 1195 / Bd1)
336
0
36363
TrEMBL
A0A1S7SGV8_9RHIZ
318
0
34722
TrEMBL
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32000
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2 * 32000, SDS-PAGE
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dimer
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2 * 32000, SDS-PAGE
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partial, to near homogeneity
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Murakoshi, I.; Kuramoto, H.; Haginiwa, J.
The enzymic synthesis of beta-substituted alanines
Phytochemistry
11
177-182
1972
Leucaena leucocephala
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brenda
Murakoshi, I.; Ikegami, F.; Hinuma, Y.; Hanma, Y.
Purification and characterization of L-mimosine synthase from Leucaema leucocephala
Phytochemistry
23
1905-1908
1984
Leucaena leucocephala
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brenda
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2.5.1.52 L-mimosine synthase
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