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Information on EC 2.6.1.123 - 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming)

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EC Tree
IUBMB Comments
The enzyme, characterized from the bacterium Bacillus subtilis, is a heterodimer. The PabA subunit acts successively on two molecules of L-glutamine, hydrolysing each to L-glutamate and ammonia (cf. EC 3.5.1.2, glutaminase). The ammonia molecules are channeled to the active site of PabB, which catalyses the formation of 4-amino-4-deoxychorismate from chorismate in two steps via the intermediate 2-amino-4-deoxychorismate. cf. EC 2.6.1.85, aminodeoxychorismate synthase.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
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Synonyms
ADC synthase, ADCS, PabAB, PabB, Smlt1032, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2S)-2-amino-4-deoxychorismate + NH3 = 4-amino-4-deoxychorismate + NH3
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(1c)
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2 L-glutamine + 2 H2O = 2 L-glutamate + 2 NH3
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(1a)
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chorismate + 2 L-glutamine + H2O = 4-amino-4-deoxychorismate + 2 L-glutamate + ammonia
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overall reaction
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chorismate + NH3 = (2S)-2-amino-4-deoxychorismate + H2O
show the reaction diagram
(1b)
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PATHWAY SOURCE
PATHWAYS
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