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EC Tree
IUBMB Comments D-Glucose 6-phosphate can act as acceptor, forming alpha-D-glucose 1,6-bisphosphate.
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
pgm2l1, phosphoglucomutase 2, glucose-1,6-bisphosphate synthase,
more
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glucose 1,6-diphosphate synthase
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glucose-1,6-bisphosphate synthetase
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3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate
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phospho group transfer
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3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase
D-Glucose 6-phosphate can act as acceptor, forming alpha-D-glucose 1,6-bisphosphate.
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3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
3-phospho-D-glyceroyl phosphate + D-glucose 6-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
3-phospho-D-glyceroyl phosphate + D-mannose 1-phosphate
3-phospho-D-glycerate + D-mannose 1,6-bisphosphate
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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i.e. 1,3-diphosphoglycerate
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3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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specific for 3-phospho-D-glyceroyl phosphate
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3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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no acceptor activity mannose 6-phosphate
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3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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i.e. 1,3-diphosphoglycerate
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3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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no phosphoryl donors are acetyl phosphate, ATP, phosphoenolpyruvate, creatine phosphate, fructose 1,6-diphosphate
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3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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little or no acceptor activity: glucose, glucose 6-sulfate, glucosamine 6-phosphate, 2-deoxy-glucose 6-phosphate, 3-phosphoglycerate, galactose or fructose monophosphates
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3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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no acceptor activity mannose 6-phosphate
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3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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responsible for glucose 1,6-diphosphate biosynthesis in brain
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3-phospho-D-glyceroyl phosphate + D-glucose 6-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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3-phospho-D-glyceroyl phosphate + D-glucose 6-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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phosphorylation at 56% the rate of glucose 1-phosphate
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3-phospho-D-glyceroyl phosphate + D-mannose 1-phosphate
3-phospho-D-glycerate + D-mannose 1,6-bisphosphate
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3-phospho-D-glyceroyl phosphate + D-mannose 1-phosphate
3-phospho-D-glycerate + D-mannose 1,6-bisphosphate
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phosphorylation at 81% the rate of glucose 1-phosphate
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3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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responsible for glucose 1,6-diphosphate biosynthesis in brain
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r
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Ca2+
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requirement, can be replaced by Mg2+, Mn2+, Zn2+, Ni2+, Co2+, Cd2+
Cd2+
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requirement, can be replaced by Mg2+, Mn2+, Ca2+, Zn2+, Ni2+, Co2+
Mn2+
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requirement, can be replaced by Mg2+, Ca2+, Zn2+, Ni2+, Co2+, Cd2+
Ni2+
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requirement, can be replaced by Mg2+, Mn2+, Ca2+, Zn2+, Co2+, Cd2+
Co2+
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tightly bound, can replace Zn2+
Co2+
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requirement, can be replaced by Mg2+, Mn2+, Ca2+, Zn2+, Ni2+, Cd2+
Mg2+
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Mg2+
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no activation of enzyme in Zn-form
Mg2+
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activation, easily dissociates from enzyme protein
Mg2+
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requirement, can be replaced by Mn2+, Ca2+, Zn2+, Ni2+, Co2+, Cd2+
Zn2+
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Zn-form of the enzyme: tightly bound, about 65% of brain enzyme in Zn-form
Zn2+
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requirement, can be replaced by Mg2+, Mn2+, Ca2+, Ni2+, Co2+, Cd2+
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2,3-bisphosphoglycerate
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0.2 mM, strong inhibitor
D-fructose 1,6-diphosphate
D-Glucose 1,6-bisphosphate
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0.01 mM, 50% inhibition
D-glucose 1,6-diphosphate
glycerate 2,3-diphosphate
glycerol 3-phosphate
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0.2 mM, strong inhibitor
Li+
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strong, dilution, Co2+ or Zn2+ protects, not Ca2+, Mg2+ or Mn2+
additional information
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no inhibition by adipate or succinate
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D-fructose 1,6-diphosphate
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strong, liver
D-fructose 1,6-diphosphate
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D-fructose 1,6-diphosphate
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D-glucose 1,6-diphosphate
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D-glucose 1,6-diphosphate
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glycerate 2,3-diphosphate
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strong, liver
glycerate 2,3-diphosphate
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glycerate 2,3-diphosphate
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Glycerate 3-phosphate
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Glycerate 3-phosphate
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weak
phosphate
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phosphoenolpyruvate
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strong
phosphoenolpyruvate
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strong
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glucose-1,6-bisphosphate synthase deficiency
Impaired glucose-1,6-biphosphate production due to bi-allelic PGM2L1 mutations is associated with a neurodevelopmental disorder.
Sarcoma
Mapping the sheep genome: production of characterized sheep x hamster cell hybrids.
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0.000087 - 0.00045
3-phospho-D-glyceroyl 1-phosphate
0.009 - 0.16
D-glucose 1-phosphate
0.015 - 0.061
D-glucose 6-phosphate
0.000087
3-phospho-D-glyceroyl 1-phosphate
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23°C, pH 8, Mg2+-enzyme in brain
0.000091
3-phospho-D-glyceroyl 1-phosphate
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23°C, pH 8, Zn2+-enzyme in brain
0.00023
3-phospho-D-glyceroyl 1-phosphate
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25°C, pH 7.5, liver enzyme peak I
0.00028
3-phospho-D-glyceroyl 1-phosphate
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25°C, pH 7.5, liver enzyme peak II
0.00045
3-phospho-D-glyceroyl 1-phosphate
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25°C, pH 7.5, erythrocyte enzyme
0.009
D-glucose 1-phosphate
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25°C, pH 7.5, liver enzyme peak I
0.059
D-glucose 1-phosphate
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25°C, pH 7.5, liver enzyme peak II
0.09
D-glucose 1-phosphate
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23°C, pH 8, Mg2+- and Zn2+-enzyme in brain
0.16
D-glucose 1-phosphate
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25°C, pH 7.5, erythrocyte enzyme
0.015
D-glucose 6-phosphate
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25°C, pH 7.5, liver enzyme peak I
0.061
D-glucose 6-phosphate
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25°C, pH 7.5, liver enzyme peak II
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0.136
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erythrocyte enzyme
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7.3 - 8.7
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about half-maximal activity at pH 7.3 and 8.7
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25
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assay at
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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PGM2L_HUMAN
622
0
70442
Swiss-Prot
other Location (Reliability: 1 )
PGM2L_MOUSE
621
0
70279
Swiss-Prot
other Location (Reliability: 1 )
PGM2L_PONAB
622
0
70456
Swiss-Prot
other Location (Reliability: 1 )
A0A291SRH8_STRMQ
582
0
61034
TrEMBL
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A0A086PUM0_TOXGO
597
0
65880
TrEMBL
Mitochondrion (Reliability: 4 )
D1A257_THECD
Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / KCTC 9072 / NBRC 15933 / NCIMB 10081 / Henssen B9)
558
0
58581
TrEMBL
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D5WY15_KYRT2
Kyrpidia tusciae (strain DSM 2912 / NBRC 15312 / T2)
584
0
63502
TrEMBL
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D3EBS1_GEOS4
Geobacillus sp. (strain Y412MC10)
575
0
62676
TrEMBL
-
A0A086LKE9_TOXGO
597
0
65850
TrEMBL
Mitochondrion (Reliability: 4 )
D2SG68_GEOOG
Geodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 / KCC A-0152 / KCTC 9177 / NBRC 13315 / NRRL B-3577 / G-20)
539
0
56117
TrEMBL
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D5U3R4_BRAM5
Brachyspira murdochii (strain ATCC 51284 / DSM 12563 / 56-150)
563
0
63005
TrEMBL
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A0A378XBL5_PANTH
573
0
61961
TrEMBL
-
D2C6S7_THENR
Thermotoga naphthophila (strain ATCC BAA-489 / DSM 13996 / JCM 10882 / RKU-10)
471
0
53017
TrEMBL
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A0A061IBN9_CRIGR
179
0
20043
TrEMBL
other Location (Reliability: 1 )
D6ZCD2_SEGRD
Segniliparus rotundus (strain ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578)
558
0
58685
TrEMBL
-
A0A2G8XS23_TOXGO
597
0
65947
TrEMBL
Mitochondrion (Reliability: 4 )
A0A8M1NEU2_DANRE
619
0
69308
TrEMBL
other Location (Reliability: 2 )
C6D5B6_PAESJ
Paenibacillus sp. (strain JDR-2)
570
0
62278
TrEMBL
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D2PKI1_KRIFD
Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)
545
0
56888
TrEMBL
-
A0A425HP89_TOXGO
597
0
65880
TrEMBL
Mitochondrion (Reliability: 4 )
D5UUP4_TSUPD
Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / CCUG 35730 / CIP 100753 / JCM 10117 / KCTC 9821 / NBRC 16120 / NCIMB 702349 / NCTC 13040)
541
0
55782
TrEMBL
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D5UKW8_CELFN
Cellulomonas flavigena (strain ATCC 482 / DSM 20109 / BCRC 11376 / JCM 18109 / NBRC 3775 / NCIMB 8073 / NRS 134)
614
0
63553
TrEMBL
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C5CGT0_KOSOT
Kosmotoga olearia (strain ATCC BAA-1733 / DSM 21960 / TBF 19.5.1)
549
0
61925
TrEMBL
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A0A125YJC3_TOXGG
Toxoplasma gondii (strain ATCC 50853 / GT1)
597
0
65896
TrEMBL
Mitochondrion (Reliability: 4 )
D6Y5R5_THEBD
Thermobispora bispora (strain ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / KCTC 9307 / NBRC 14880 / R51)
545
0
56985
TrEMBL
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D2BD39_STRRD
Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
547
0
56438
TrEMBL
-
A0A086JFY0_TOXGO
597
0
65896
TrEMBL
Mitochondrion (Reliability: 4 )
C8XE97_NAKMY
Nakamurella multipartita (strain ATCC 700099 / DSM 44233 / CIP 104796 / JCM 9543 / NBRC 105858 / Y-104)
561
0
58402
TrEMBL
-
A0A086JVP4_TOXGO
597
0
65896
TrEMBL
Mitochondrion (Reliability: 4 )
B9PVD0_TOXGV
Toxoplasma gondii (strain ATCC 50861 / VEG)
597
0
65896
TrEMBL
Mitochondrion (Reliability: 4 )
N0CV77_STRMI
546
0
57047
TrEMBL
-
D3Q7Y0_STANL
Stackebrandtia nassauensis (strain DSM 44728 / CIP 108903 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)
553
0
58378
TrEMBL
-
D3EMH3_GEOS4
Geobacillus sp. (strain Y412MC10)
572
0
62670
TrEMBL
-
A0A086PRB5_TOXGO
597
0
65880
TrEMBL
Mitochondrion (Reliability: 4 )
A0A086KGP6_TOXGO
597
0
65896
TrEMBL
Mitochondrion (Reliability: 4 )
D0LDW6_GORB4
Gordonia bronchialis (strain ATCC 25592 / DSM 43247 / BCRC 13721 / JCM 3198 / KCTC 3076 / NBRC 16047 / NCTC 10667)
562
0
58919
TrEMBL
-
S8GS96_TOXGM
Toxoplasma gondii (strain ATCC 50611 / Me49)
597
0
65882
TrEMBL
Mitochondrion (Reliability: 4 )
A0A139XK63_TOXGO
597
0
65896
TrEMBL
Mitochondrion (Reliability: 4 )
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expression in Escherichia coli as fusion protein with a polyHis tag at their N-terminus
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Rose, I.A.; Warms, J.V.B.; Kaklij, G.
A specific enzyme for glucose 1,6-bisphosphate synthesis
J. Biol. Chem.
250
3466-3470
1975
Mus musculus
brenda
Ueda, M.; Hirose, M.; Sasaki, R.; Chiba, H.
Regulation of glucose 1,6-bisphosphate level in liver. III. Purification and properties of bovine glucose 1,6-bisphosphate synthase
J. Biochem.
83
1721-1730
1978
Bos taurus
brenda
Rose, I.A.; Warms, J.V.B.; Wong, L.J.
Inhibitors of glucose-1,6-bisphosphate synthase
J. Biol. Chem.
252
4262-4268
1977
Bos taurus
brenda
Maliekal, P.; Sokolova, T.; Vertommen, D.; Veiga-da-Cunha, M.; Van Schaftingen, E.
Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the alpha-D-phosphohexomutase family
J. Biol. Chem.
282
31844-31851
2007
Homo sapiens
brenda
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