Disease on EC 2.7.4.9 - dTMP kinase
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Acquired Immunodeficiency Syndrome
Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation.
Anthrax
Synthesis and biological evaluation of inhibitors of thymidine monophosphate kinase from Bacillus anthracis.
Ataxia Telangiectasia
Thymidylate kinase is critical for DNA repair via ATM-dependent Tip60 complex formation.
Carcinoma, Hepatocellular
Growth inhibition of Kirkman-Robbins hepatoma by 1-(1,3-dihydroxy-2-propoxymethyl)-5,6-tetramethyleneuracil and possible mechanism of its biological activity.
Carcinoma, Hepatocellular
Metabolism of 5-fluorouracil in sensitive and resistant tumor cells.
Carcinoma, Hepatocellular
Purification and properties of thymidine monophosphate kinase from mouse hepatoma.
Colonic Neoplasms
Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status.
Embryo Loss
Enzymatic activities leading to pyrimidine nucleotide biosynthesis from cell-free extracts of Rickettsia typhi.
Herpes Simplex
An optimized thymidylate kinase assay, based on enzymatically synthesized 5-[125I]iododeoxyuridine monophosphate and its application to an immunological study of herpes simplex virus thymidine-thymidylate kinases.
HIV Infections
Decrease in thymidylate kinase activity in peripheral blood mononuclear cells from HIV-infected individuals.
Hypersensitivity
Substitution of an alanine residue for glycine 146 in TMP kinase from Escherichia coli is responsible for bacterial hypersensitivity to bromodeoxyuridine.
Infections
Vaccinia virus encodes a thymidylate kinase gene: sequence and transcriptional mapping.
Latent Infection
Low levels of herpes simplex virus thymidine- thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model.
Neoplasms
Activities of various enzymes of pyrimidine nucleotide and DNA syntheses in normal and neoplastic human tissues.
Neoplasms
An optimized thymidylate kinase assay, based on enzymatically synthesized 5-[125I]iododeoxyuridine monophosphate and its application to an immunological study of herpes simplex virus thymidine-thymidylate kinases.
Neoplasms
Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy.
Neoplasms
Growth inhibition of Kirkman-Robbins hepatoma by 1-(1,3-dihydroxy-2-propoxymethyl)-5,6-tetramethyleneuracil and possible mechanism of its biological activity.
Neoplasms
Metabolism of pyrimidine nucleotides in various tissues and tumor cells from rodents.
Neoplasms
The engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis offers efficient bystander cell killing for suicide gene therapy of cancer.
Neoplasms
Tumor cells require thymidylate kinase to prevent dUTP incorporation during DNA repair.
Neuroblastoma
Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth.
Prostatic Neoplasms
The engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis offers efficient bystander cell killing for suicide gene therapy of cancer.
Pseudorabies
Equine herpes virus 1 and pseudorabies virus resistance to 2'-fluoropyrimidine analogs and to bromovinyldeoxyuridine: implications for dTMP kinase activity.
Tuberculosis
1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors.
Tuberculosis
1-(Piperidin-3-yl)thymine amides as inhibitors of M. tuberculosis thymidylate kinase.
Tuberculosis
3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.
Tuberculosis
3D-QSAR studies on antitubercular thymidine monophosphate kinase inhibitors based on different alignment methods.
Tuberculosis
A new family of inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.
Tuberculosis
A virtual screening approach for thymidine monophosphate kinase inhibitors as antitubercular agents based on docking and pharmacophore models.
Tuberculosis
Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans.
Tuberculosis
Computer-assisted combinatorial design of bicyclic thymidine analogs as inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.
Tuberculosis
Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors.
Tuberculosis
Design of Thymidine Analogues Targeting Thymidilate Kinase of Mycobacterium tuberculosis.
Tuberculosis
Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone.
Tuberculosis
Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.
Tuberculosis
Drug design and identification of potent leads against Mycobacterium tuberculosis thymidine monophosphate kinase.
Tuberculosis
Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.
Tuberculosis
Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Tuberculosis
Identification of novel antimycobacterial chemical agents through the in silico multi-conformational structure-based drug screening of a large-scale chemical library.
Tuberculosis
Knowledge based identification of potent antitubercular compounds using structure based virtual screening and structure interaction fingerprints.
Tuberculosis
Mycobacterium tuberculosis thymidylate kinase: structural studies of intermediates along the reaction pathway.
Tuberculosis
Optimization of Structure Based Virtual Screening Protocols Against Thymidine Monophosphate Kinase Inhibitors as Antitubercular Agents.
Tuberculosis
Pharmacophore optimization and design of competitive inhibitors of Thymidine Monophosphate Kinase through molecular modeling studies.
Tuberculosis
Rational Design and 3D-Pharmacophore Mapping of 5'-Thiourea-Substituted alpha-Thymidine Analogues as Mycobacterial TMPK Inhibitors.
Tuberculosis
Rational Design of 5'-Thiourea-Substituted alpha-Thymidine Analogues as Thymidine Monophosphate Kinase Inhibitors Capable of Inhibiting Mycobacterial Growth.
Tuberculosis
Structural and chemical basis for enhanced affinity to a series of mycobacterial thymidine monophosphate kinase inhibitors: fragment-based QSAR and QM/MM docking studies.
Tuberculosis
Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors.
Tuberculosis
Structure-based in-silico rational design of a selective peptide inhibitor for thymidine monophosphate kinase of mycobacterium tuberculosis.
Tuberculosis
Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity.
Tuberculosis
Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M. tuberculosis thymidylate kinase.
Tuberculosis
Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors.
Tuberculosis
Synthesis and Evaluation of 6-Aza-2'-deoxyuridine Monophosphate Analogs as Inhibitors of Thymidylate Synthases, and as Substrates or Inhibitors of Thymidine Monophosphate Kinase in Mycobacterium tuberculosis.
Tuberculosis
Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Tuberculosis
Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase.
Tuberculosis
Synthesis of sulfamide analogues of deoxthymidine monophosphate as potential inhibitors of mycobacterial cell wall biosynthesis.
Tuberculosis
Tetrahydro-2-furanyl-2,4(1H,3H)-pyrimidinedione derivatives as novel antibacterial compounds against
Tuberculosis
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Tuberculosis
X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1.95 A resolution.
Vaccinia
Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy.
Vaccinia
Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast.
Vaccinia
Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase.
Vaccinia
Preventing the return of smallpox: molecular modeling studies on thymidylate kinase from Variola virus.
Vaccinia
Vaccinia virus encodes a thymidylate kinase gene: sequence and transcriptional mapping.
Vaccinia
Vaccinia virus encodes an active thymidylate kinase that complements a cdc8 mutant of Saccharomyces cerevisiae.
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