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Information on EC 2.7.7.60 - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

for references in articles please use BRENDA:EC2.7.7.60
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IUBMB Comments
The enzyme from Escherichia coli requires Mg2+ or Mn2+. ATP or UTP can replace CTP, but both are less effective. GTP and TTP are not substrates. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here).
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
2-C-methyl erythritol 4-phosphate cytidylyltransferase, 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase, 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 2-C-methyl-D-erythritol-4-phosphate cytidylyltransferase, 2-C-methylerythritol 4-cytidylyltransferase, 2C-methyl-D-erythritol-4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2-C-methyl-D-erythritol synthetase, 4-diphosphocytidyl-2-C-methylerythritol synthase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, CDP-ME synthetase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
show the reaction diagram
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