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Information on EC 2.7.7.65 - diguanylate cyclase

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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.65 diguanylate cyclase
IUBMB Comments
A GGDEF-domain-containing protein that requires Mg2+ or Mn2+ for activity. The enzyme can be activated by BeF3, a phosphoryl mimic, which results in dimerization . Dimerization is required but is not sufficient for diguanylate-cyclase activity . Cyclic di-3',5'-guanylate is an intracellular signalling molecule that controls motility and adhesion in bacterial cells. It was first identified as having a positive allosteric effect on EC 2.4.1.12, cellulose synthase (UDP-forming) .
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
AdrA, ALL2874, atu1060, atu1297, BifA, CdgA, CdgB, CelR, Chp8, cyclic dimeric GMP [c-di-GMP] B, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 GTP = 2 diphosphate + cyclic di-3',5'-guanylate
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