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3-alpha-D-glucopyranosyl-1,2-di-palmitoylglycerol + CDP-choline
CMP + 3-(6-O-cholinephosphoryl-alpha-D-glucopyranosyl)-1,2-dipalmitoylglycerol
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + phosphatidylcholine
-
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
CDP-choline + 1,2-dilinolenoyl-sn-glycerol
CMP + 1,2-dilinolenoylphosphatidylcholine
-
-
-
-
?
CDP-choline + 1,2-dioleoyl-sn-glycerol
?
-
the most preferred diacylglycerol substrate is 18:0/20:4 diacylglycerol, followed by 18:0/22:6 diacylglycerol. The specific activities for 18:0/20:4 diacylglycerol and 18:0/22:6 diacylglycerol are 26 and 14fold higher than those of other diacylglycerol species
-
-
?
CDP-choline + 1,2-dioleoyl-sn-glycerol
CMP + 1,2-dioleoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
CDP-choline + 1,2-dipalmitoyl-sn-glycerol
CMP + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
CDP-choline + 1-arachidoyl-2-oleoyl-sn-glycerol
CMP + 1-arachidoyl-2-oleoyl-sn-glycerophosphocholine
-
-
-
-
?
CDP-choline + 1-batyl-2-acetyl-sn-glycerol
CMP + 1-batyl-2-acetyl-sn-glycero-3-phosphocholine
-
-
-
-
?
CDP-choline + 1-chimyl-2-acetyl-sn-glycerol
CMP + 1-chimyl-2-acetyl-sn-glycero-3-phosphocholine
-
-
-
-
?
CDP-choline + 1-heptadecanoyl-2-oleoyl-sn-glycerol
CMP + 1-heptadecanoyl-2-oleoyl-sn-glycerophosphocholine
-
-
-
-
?
CDP-choline + 1-hexadecanoyl-2-octadecanoyl-sn-glycerol
CMP + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
CDP-choline + 1-hexadecyl-2-acetyl-sn-glycerol
CMP + 1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine
-
-
-
-
?
CDP-choline + 1-hexadecyl-2-octadecanoyl-sn-glycerol
CMP + 1-hexadecyl-2-octadecanoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
CDP-choline + 1-hexadecyl-2-octadecenoyl-sn-glycerol
CMP + 1-hexadecyl-2-octadecenoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
CDP-choline + 1-lauroyl-2-oleoyl-sn-glycerol
CMP + 1-lauroyl-2-oleoyl-sn-glycerophosphocholine
-
-
-
-
?
CDP-choline + 1-myristoyl-2-oleoyl-sn-glycerol
CMP + 1-myristoyl-2-oleoyl-sn-glycerophosphocholine
-
-
-
-
?
CDP-choline + 1-nonadecanoyl-2-oleoyl-sn-glycerol
CMP + 1-nonadecanoyl-2-oleoyl-sn-glycerophosphocholine
-
-
-
-
?
CDP-choline + 1-O-alkyl-2-acetyl-sn-glycerol
CMP + 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine
CDP-choline + 1-O-hexadecyl-2-acetyl-sn-glycerol
CMP + 1-O-hexadecyl-2-acetyl-sn-glycero-phosphocholine
-
-
-
-
?
CDP-choline + 1-palmitoyl-2-linoleoylglycerol
CMP + 1-palmitoyl-2-linoleoylglycero-3-phosphocholine
CDP-choline + 1-palmitoyl-2-oleoyl-sn-glycerol
CMP + 1-palmitoyl-2-oleoyl-sn-glycerophosphocholine
-
-
-
-
?
CDP-choline + 1-pentadecanoyl-2-oleoyl-sn-glycerol
CMP + 1-pentadecanoyl-2-oleoyl-sn-glycerophosphocholine
-
-
-
-
?
CDP-choline + 1-selachyl-2-acetyl-sn-glycerol
CMP + 1-selachyl-2-acetyl-sn-glycero-3-phosphocholine
-
-
-
-
?
CDP-choline + 1-stearoyl-2-oleoyl-sn-glycerol
CMP + 1-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
CDP-choline + 1-stearoyl-2-oleoyl-sn-glycerol
CMP + 1-stearoyl-2-oleoyl-sn-glycerophosphocholine
-
-
-
-
?
CDP-choline + 1-tridecanoyl-2-oleoyl-sn-glycerol
CMP + 1-tridecanoyl-2-oleoyl-sn-glycerophosphocholine
-
-
-
-
?
CDP-choline + bacterial 1,2-diacyl-sn-glycerol
CMP + phosphatidylethanolamine
-
-
-
-
?
CDP-choline + didecanoylglycerol
CMP + didecanoylglycerophosphocholine
CDP-choline + didodecanoylglycerol
CMP + didodecanoylglycerophosphocholine
-
-
-
-
?
CDP-choline + dihexanoylglycerol
CMP + dihexanoylglycerophosphocholine
CDP-choline + dimyristoyl-sn-glycerol
CMP + dimyristoyl-sn-glycerophosphocholine
-
-
-
-
?
CDP-choline + dioctanoylglycerol
CMP + dioctanoylglycerophosphocholine
-
at 5-10% of the activity with dioleoylglycerol or egg diglycerides
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
CDP-choline + sn-1,2-dioleoylglycerol
CMP + ?
-
-
-
-
?
CDP-ethanolamine + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylethanolamine
CDP-ethanolamine + 1,2-diacylglycerol
CMP + phosphatidylethanolamine
CMP + a phosphatidylcholine
CDP-choline + 1,2-diacylglycerol
-
-
-
r
CMP + phosphatidylcholine
?
CMP + phosphatidylcholine
CDP-choline + 1,2-diacylglycerol
dCDP-choline + 1,2-diacylglycerol
CMP + 1,2-diacylglycero-3-phosphocholine
-
-
-
-
?
additional information
?
-
3-alpha-D-glucopyranosyl-1,2-di-palmitoylglycerol + CDP-choline
CMP + 3-(6-O-cholinephosphoryl-alpha-D-glucopyranosyl)-1,2-dipalmitoylglycerol
-
-
-
?
3-alpha-D-glucopyranosyl-1,2-di-palmitoylglycerol + CDP-choline
CMP + 3-(6-O-cholinephosphoryl-alpha-D-glucopyranosyl)-1,2-dipalmitoylglycerol
-
-
-
?
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
enzyme phosphatidylcholine diacylglycerol cholinephosphotransferase catalyzes the interconversion between phosphatidylcholine and diacylglycerol
-
-
r
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
r
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
preferred substrates in decreasing order: di-10:0 diacylglycerol, di-16:1 diacylglycerol, di-8:0 diacylglycerol, di-18:1 diacylglycerol, 16:0/22:6 diacylglycerol
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
preferred substrates in decreasing order, activation by Mg2+: di18:1-diacylglycerol, 16:0/22:6-diacylglycerol, 16:0/18:1-diacylglycerol, 18:0/20:4-diacylglycerol, di16:0-diacylglycerol, preferred substrates in decreasing order, activation by Mn2+: di10:0-diacylglycerol, 18:1/2:0-diacylglycerol, 16:0/22:6-diacylglycerol, di18:1-diacylglycerol, di16:0-diacylglycerol, di14:1-diacylglycerol, di16:1-diacylglycerol
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
preferred substrates: di-18:1-diacylglycerol, di-16:1-diacylglycerol, 16:0/18:1-diacylglycerol, 16:0/22:6-diacylglycerol
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-dipalmitoyl-sn-glycerol
CMP + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
-
preferred substrate over other disaturated species
-
-
?
CDP-choline + 1,2-dipalmitoyl-sn-glycerol
CMP + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
-
poor substrate
-
-
?
CDP-choline + 1-O-alkyl-2-acetyl-sn-glycerol
CMP + 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine
-
platelet activating factor (PAF) de novo biosynthesis
-
-
?
CDP-choline + 1-O-alkyl-2-acetyl-sn-glycerol
CMP + 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine
-
37°C, 20 min, pH 8, in presence of 15 mM dithiothreitol, 5 mM EDTA, 20 mM MgCl2, 1 mg/ml bovine serum albumin
analysis by thin-layer chromatography
-
?
CDP-choline + 1-palmitoyl-2-linoleoylglycerol
CMP + 1-palmitoyl-2-linoleoylglycero-3-phosphocholine
-
preferred substrate
-
-
?
CDP-choline + 1-palmitoyl-2-linoleoylglycerol
CMP + 1-palmitoyl-2-linoleoylglycero-3-phosphocholine
-
preferred substrate
-
-
?
CDP-choline + didecanoylglycerol
CMP + didecanoylglycerophosphocholine
-
-
-
-
?
CDP-choline + didecanoylglycerol
CMP + didecanoylglycerophosphocholine
-
at 5-10% of the activity with dioleoylglycerol or egg diglycerides
-
-
?
CDP-choline + dihexanoylglycerol
CMP + dihexanoylglycerophosphocholine
-
-
-
-
?
CDP-choline + dihexanoylglycerol
CMP + dihexanoylglycerophosphocholine
-
at 5-10% of the activity with dioleoylglycerol or egg diglycerides
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
dithiothreitol-sensitive activity
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
final reaction in synthesis of phosphatidylcholine
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
dithiothreitol-sensitive activity
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
final reaction in synthesis of phosphatidylcholine
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
final reaction in synthesis of phosphatidylcholine
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
dithiothreitol-sensitive activity
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
final reaction in synthesis of phosphatidylcholine
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
dithiothreitol-sensitive activity
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
final reaction in synthesis of phosphatidylcholine
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
final reaction in synthesis of phosphatidylcholine
-
-
r
CDP-ethanolamine + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylethanolamine
-
-
-
r
CDP-ethanolamine + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylethanolamine
-
-
-
r
CDP-ethanolamine + 1,2-diacylglycerol
CMP + phosphatidylethanolamine
-
-
-
r
CDP-ethanolamine + 1,2-diacylglycerol
CMP + phosphatidylethanolamine
-
-
-
-
r
CDP-ethanolamine + 1,2-diacylglycerol
CMP + phosphatidylethanolamine
-
preferred substrates in decreasing order: di-18:1 diacylglycerol, di-16:1 diacylglycerol, 16:0/18:1 diacylglycerol, 16:0/22:6 diacylglycerol
-
-
?
CDP-ethanolamine + 1,2-diacylglycerol
CMP + phosphatidylethanolamine
-
preferred substrates: 16:0/18:1 diacylglycerol, di-18:1 diacylglycerol, di-18:1 diacylglycerol
-
-
?
CMP + phosphatidylcholine
?
-
-
-
-
?
CMP + phosphatidylcholine
?
-
principal pathway for degradation of phosphatidylcholine, particularly during brain ischemia, followed by hydrolysis of diacylglycerols by the lipase
-
-
?
CMP + phosphatidylcholine
CDP-choline + 1,2-diacylglycerol
-
-
-
-
r
CMP + phosphatidylcholine
CDP-choline + 1,2-diacylglycerol
-
-
-
-
r
additional information
?
-
-
little or no specificity across a range of different diacylglycerol substrates
-
-
?
additional information
?
-
-
PDCT accepts substrates with different desaturation levels. PDCT is unable to use diacylglycerols with ricineoleyl groups, and the presence of this substrate also inhibits PDCT from using other diacylglycerol moieties
-
-
-
additional information
?
-
-
little or no specificity across a range of different diacylglycerol substrates
-
-
?
additional information
?
-
-
significant preference for unsaturated diacylglycerols over saturated sialylglycerols
-
-
?
additional information
?
-
-
little or no specificity across a range of different diacylglycerol substrates
-
-
?
additional information
?
-
the enzyme has dual specificity for both CDP-choline and CDP-ethanolamine, EC 2.7.8.1
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
lacks specificity for the type of diglyceride
-
-
?
additional information
?
-
-
dithiothreitol-insensitive activity
-
-
?
additional information
?
-
-
final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway
-
-
?
additional information
?
-
-
overview: substrate specificity
-
-
?
additional information
?
-
-
ultimate step in the Kennedy pathway for the genesis of de novo synthesized phosphatidylcholine
-
-
?
additional information
?
-
the enzyme is specific for CDP-choline, no activity with CDP-ethanolamine. The reaction occurs at the hydrophobic-hydrophilic interface of membranes which impacts kinetic behavior
-
-
?
additional information
?
-
-
overview: substrate specificity
-
-
?
additional information
?
-
no substrates: 16:0(O)/2:0-diacylglycerol, 16:0(O)/20:4-diacylglycerol
-
-
?
additional information
?
-
-
no substrates: 16:0(O)/2:0-diacylglycerol, 16:0(O)/20:4-diacylglycerol
-
-
?
additional information
?
-
-
ultimate step in the Kennedy pathway for the genesis of de novo synthesized phosphatidylcholine
-
-
?
additional information
?
-
-
dithiothreitol-insensitive activity
-
-
?
additional information
?
-
-
dithiothreitol-insensitive activity
-
-
?
additional information
?
-
-
final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway
-
-
?
additional information
?
-
-
final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway
-
-
?
additional information
?
-
-
increase in cholinephosphotransferase gene expression with cadmium in all cell lines, significant increase in 11-9-1-4 cells and MCF-12F cells. Cell lines MCF-12F, MCF-7, BT-549 and 11-9-1-4 show mutations in their nucleotide sequence as the result of cadmium treatment. The effect of cadmium is highest in MCF-12F cell line that shows a total of six mutations
-
-
?
additional information
?
-
the enzyme has dual specificity for both CDP-choline and CDP-ethanolamine, EC 2.7.8.1
-
-
?
additional information
?
-
the enzyme has dual specificity for both CDP-choline and CDP-ethanolamine, EC 2.7.8.1
-
-
?
additional information
?
-
the enzyme is specific for CDP-choline, no activity with CDP-ethanolamine. The reaction occurs at the hydrophobic-hydrophilic interface of membranes which impacts kinetic behavior
-
-
?
additional information
?
-
the enzyme is specific for CDP-choline, no activity with CDP-ethanolamine. The reaction occurs at the hydrophobic-hydrophilic interface of membranes which impacts kinetic behavior
-
-
?
additional information
?
-
-
overview: substrate specificity
-
-
?
additional information
?
-
-
ultimate step in the Kennedy pathway for the genesis of de novo synthesized phosphatidylcholine
-
-
?
additional information
?
-
-
renal mRNA expression of cholinephosphotransferase 1 may be involved in the development and/or progression of diabetic nephropathy
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
role of enzyme in de novo and remodeling pathways
-
-
?
additional information
?
-
-
dithiothreitol-insensitive activity
-
-
?
additional information
?
-
-
final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
specificity overview
-
-
?
additional information
?
-
-
specificity overview
-
-
?
additional information
?
-
-
specificity overview
-
-
?
additional information
?
-
-
overview: substrate specificity
-
-
?
additional information
?
-
-
higher activity with 16:0 and 18:1 substrates than with 18:0 substrates
-
-
?
additional information
?
-
-
influence of saturated fatty acids on the enzyme activities depends on their location at the C-1 or C-2 position of glycerol
-
-
?
additional information
?
-
-
no substrate: 1,3-diC18:1-glycerol ether
-
-
?
additional information
?
-
-
no substrate: 1,2-diC18:1-glycerol ether
-
-
?
additional information
?
-
-
no substrate: AMP
-
-
?
additional information
?
-
-
1-acyl-2-oleoylglycerols, ranging from 1-lauroyl to 1-heptadecanoyl species are equally well utilized, fully saturated diacylglycerols like dipalmitoylglycerol are poorly utilized, several 1-oleoyl-2-saturated types of diacylglycerol are effectively used
-
-
?
additional information
?
-
-
dithiothreitol-insensitive enzyme prefers a lipid substrate with 16:0 or 18:1 sn-1-alkyl chains
-
-
?
additional information
?
-
-
short chain esters at the sn-2 position (acetate or propionate) are utilized
-
-
?
additional information
?
-
-
a marked preference of the enzyme for the 1-palmitoyl over the 1-stearoyl homologue is observed with all 4 unsaturation classes of diacylglycerols
-
-
?
additional information
?
-
-
no substrate: UMP
-
-
?
additional information
?
-
-
substrates are 1,2-diacylglycerols containing fatty acids 6, 12 and 14 carbons in length
-
-
?
additional information
?
-
-
no substrate: analogs with acetamide or methoxy substituents at the sn-2-position
-
-
?
additional information
?
-
-
the reversibility of phosphoethanolamine transferase and phosphocholine transferase permits the interconversion of diacylglycerol moieties of choline and ethanolamine glycerophospholipids
-
-
?
additional information
?
-
-
ultimate step in the Kennedy pathway for the genesis of de novo synthesized phosphatidylcholine
-
-
?
additional information
?
-
-
renal dithiothreitol-insensitive enzyme could be a potentially important enzyme in the regulation of systemic blood pressure
-
-
?
additional information
?
-
-
last step in de novo synthesis of diacylglycerophosphocholine
-
-
?
additional information
?
-
-
dithiothreitol-insensitive activity
-
-
?
additional information
?
-
-
dithiothreitol-insensitive activity
-
-
?
additional information
?
-
-
final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway
-
-
?
additional information
?
-
-
final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway
-
-
?
additional information
?
-
-
final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway
-
-
?
additional information
?
-
-
significant selectivity which may be of considerable importance in maintaining the characteristic composition of fatty acyl chains in membrane phospholipids
-
-
?
additional information
?
-
-
little or no specificity across a range of different diacylglycerol substrates
-
-
?
additional information
?
-
-
specificity overview
-
-
?
additional information
?
-
-
overview: substrate specificity
-
-
?
additional information
?
-
-
ultimate step in the Kennedy pathway for the genesis of de novo synthesized phosphatidylcholine
-
-
?
additional information
?
-
the enzyme is specific for CDP-choline, no activity with CDP-ethanolamine. The reaction occurs at the hydrophobic-hydrophilic interface of membranes which impacts kinetic behavior
-
-
?
additional information
?
-
-
the enzyme is specific for CDP-choline, no activity with CDP-ethanolamine. The reaction occurs at the hydrophobic-hydrophilic interface of membranes which impacts kinetic behavior
-
-
?
additional information
?
-
-
lipogenic enzyme is involved in biosynthesis of triacylglycerol. The low dietary n-3/n-6 polyunsaturated fatty acid ratio presented in the vegetable oil diet does not sifnificantly affect enzyme activity
-
-
?
additional information
?
-
-
no selectivity towards the molecular species of the endogenous pool of diacylglycerols
-
-
?
additional information
?
-
-
utilizes 1-myristyl phosphatidylcholine most rapidly and, in decreasing order the 1-palmitoyl and 1-stearyl species
-
-
?
additional information
?
-
-
utilizes without marked selectivity the endogenous 1,2-diacylglycerol species differing in the degree of unsaturation
-
-
?
additional information
?
-
-
dithiothreitol-insensitive activity
-
-
?
additional information
?
-
-
final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3-alpha-D-glucopyranosyl-1,2-di-palmitoylglycerol + CDP-choline
CMP + 3-(6-O-cholinephosphoryl-alpha-D-glucopyranosyl)-1,2-dipalmitoylglycerol
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + phosphatidylcholine
-
-
-
-
?
CDP-choline + 1-O-alkyl-2-acetyl-sn-glycerol
CMP + 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine
-
platelet activating factor (PAF) de novo biosynthesis
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
CDP-ethanolamine + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylethanolamine
CMP + phosphatidylcholine
?
additional information
?
-
3-alpha-D-glucopyranosyl-1,2-di-palmitoylglycerol + CDP-choline
CMP + 3-(6-O-cholinephosphoryl-alpha-D-glucopyranosyl)-1,2-dipalmitoylglycerol
-
-
-
?
3-alpha-D-glucopyranosyl-1,2-di-palmitoylglycerol + CDP-choline
CMP + 3-(6-O-cholinephosphoryl-alpha-D-glucopyranosyl)-1,2-dipalmitoylglycerol
-
-
-
?
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
enzyme phosphatidylcholine diacylglycerol cholinephosphotransferase catalyzes the interconversion between phosphatidylcholine and diacylglycerol
-
-
r
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + sn-1,2-diacylglycerol
?
-
dithiothreitol-sensitive activity
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
final reaction in synthesis of phosphatidylcholine
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
dithiothreitol-sensitive activity
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
final reaction in synthesis of phosphatidylcholine
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
final reaction in synthesis of phosphatidylcholine
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
dithiothreitol-sensitive activity
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
final reaction in synthesis of phosphatidylcholine
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
dithiothreitol-sensitive activity
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
final reaction in synthesis of phosphatidylcholine
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
final reaction in synthesis of phosphatidylcholine
-
-
r
CDP-ethanolamine + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylethanolamine
-
-
-
r
CDP-ethanolamine + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylethanolamine
-
-
-
r
CMP + phosphatidylcholine
?
-
-
-
-
?
CMP + phosphatidylcholine
?
-
principal pathway for degradation of phosphatidylcholine, particularly during brain ischemia, followed by hydrolysis of diacylglycerols by the lipase
-
-
?
additional information
?
-
the enzyme has dual specificity for both CDP-choline and CDP-ethanolamine, EC 2.7.8.1
-
-
?
additional information
?
-
-
dithiothreitol-insensitive activity
-
-
?
additional information
?
-
-
final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway
-
-
?
additional information
?
-
-
ultimate step in the Kennedy pathway for the genesis of de novo synthesized phosphatidylcholine
-
-
?
additional information
?
-
-
ultimate step in the Kennedy pathway for the genesis of de novo synthesized phosphatidylcholine
-
-
?
additional information
?
-
-
dithiothreitol-insensitive activity
-
-
?
additional information
?
-
-
dithiothreitol-insensitive activity
-
-
?
additional information
?
-
-
final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway
-
-
?
additional information
?
-
-
final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway
-
-
?
additional information
?
-
-
increase in cholinephosphotransferase gene expression with cadmium in all cell lines, significant increase in 11-9-1-4 cells and MCF-12F cells. Cell lines MCF-12F, MCF-7, BT-549 and 11-9-1-4 show mutations in their nucleotide sequence as the result of cadmium treatment. The effect of cadmium is highest in MCF-12F cell line that shows a total of six mutations
-
-
?
additional information
?
-
-
ultimate step in the Kennedy pathway for the genesis of de novo synthesized phosphatidylcholine
-
-
?
additional information
?
-
-
renal mRNA expression of cholinephosphotransferase 1 may be involved in the development and/or progression of diabetic nephropathy
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
role of enzyme in de novo and remodeling pathways
-
-
?
additional information
?
-
-
dithiothreitol-insensitive activity
-
-
?
additional information
?
-
-
final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway
-
-
?
additional information
?
-
-
the reversibility of phosphoethanolamine transferase and phosphocholine transferase permits the interconversion of diacylglycerol moieties of choline and ethanolamine glycerophospholipids
-
-
?
additional information
?
-
-
ultimate step in the Kennedy pathway for the genesis of de novo synthesized phosphatidylcholine
-
-
?
additional information
?
-
-
renal dithiothreitol-insensitive enzyme could be a potentially important enzyme in the regulation of systemic blood pressure
-
-
?
additional information
?
-
-
last step in de novo synthesis of diacylglycerophosphocholine
-
-
?
additional information
?
-
-
dithiothreitol-insensitive activity
-
-
?
additional information
?
-
-
dithiothreitol-insensitive activity
-
-
?
additional information
?
-
-
final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway
-
-
?
additional information
?
-
-
final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway
-
-
?
additional information
?
-
-
final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway
-
-
?
additional information
?
-
-
significant selectivity which may be of considerable importance in maintaining the characteristic composition of fatty acyl chains in membrane phospholipids
-
-
?
additional information
?
-
-
ultimate step in the Kennedy pathway for the genesis of de novo synthesized phosphatidylcholine
-
-
?
additional information
?
-
-
lipogenic enzyme is involved in biosynthesis of triacylglycerol. The low dietary n-3/n-6 polyunsaturated fatty acid ratio presented in the vegetable oil diet does not sifnificantly affect enzyme activity
-
-
?
additional information
?
-
-
dithiothreitol-insensitive activity
-
-
?
additional information
?
-
-
final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Banas, A.; Dahlqvist, A.; Stahl, U.; Lenman, M.; Stymne, S.
The involvement of phospholipid:diacylglycerol acyltransferases in triacylglycerol production
Biochem. Soc. Trans.
28
703-705
2000
Ricinus communis, Crepis palaestina, Crepis rubra
brenda
Gasull, T.; Sarri, E.; DeGregorio-Rocasolano, N.; Trullas, R.
NMDA receptor overactivation inhibits phospholipid synthesis by decreasing choline-ethanolamine phosphotransferase activity
J. Neurosci.
23
4100-4107
2003
Rattus norvegicus
brenda
Lee, T.C.; Blank, M.L.; Fitzgerald, V.; Snyder, F.
Formation of alkylacyl- and diacylglycerophosphocholines via diradylglycerol cholinephosphotransferase in rat liver
Biochim. Biophys. Acta
713
479-483
1982
Rattus norvegicus
brenda
Coleman, R.; Bell, R.M.
Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities
J. Biol. Chem.
252
3050-3056
1977
Rattus norvegicus
brenda
Renooij, W.; Snyder, F.
Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues
Biochim. Biophys. Acta
663
545-556
1981
Rattus norvegicus
brenda
Ghosh, S.; Oten, P.W.; Mukherjee, S.; Das, S.K.
Study of properties of cholinephosphotransferase from fetal guinea pig lung mitochondria and microsomes
Mol. Cell. Biochem.
101
157-166
1991
Cavia porcellus
brenda
Wilson, A.C.; Barran, L.R.
Study of the properties of choline phoshotransferase from fetal guinea pig lung mitochondria and microsomes
Trans. Br. Mycol. Soc.
85
141-144
1985
Fusarium oxysporum
-
brenda
Parthasarathy, S.; Cady, R.K.; Kraushaar, D.S.; Sladek, N.E.; Bauman, W.J.
Inhibition of diacylglycerol:CDPcholine cholinephosphotransferase activity by dimethylaminoethyl p-chlorophenoxyacetate
Lipids
13
161-164
1978
Rattus norvegicus
brenda
Lee, T.C.; Snyder, F.
1-Alkyl-2-acetyl-sn-glycerol cholinephosphotransferase
Methods Enzymol.
209
279-283
1992
Gallus gallus, Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
brenda
Cornell, R.B.
Cholinephosphotransferase from mammalian sources
Methods Enzymol.
209
267-272
1992
Rattus norvegicus
brenda
Lianos, E.A.; Zanglis, A.
Biosynthesis and metabolism of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine in rat glomerular mesangial cells
J. Biol. Chem.
262
8990-8993
1987
Rattus norvegicus
brenda
Woodard, D.S.; Lee, T.c.; Snyder, F.
The final step in the de novo biosynthesis of platelet-activating factor. Properties of a unique CDP-choline:1-alkyl-2-acetyl-sn-glycerol choline-phosphotransferase in microsomes from the renal inner medulla of rats
J. Biol. Chem.
262
2520-2527
1987
Rattus norvegicus
brenda
Heller, R.; Bussolino, F.; Ghigo, D.; Garbarino, G.; Pescarmona, G.; Till, U.; Bosia, A.
Stimulation of platelet-activating factor synthesis in human endothelial cells by activation of the de novo pathway. Phorbol 12-myristate 13-acetate activates 1-alkyl-2-lyso-sn-glycero-3-phosphate:acetyl-CoA acetyltransferase and dithiothreitol-insensitive 1-alkyl-2-acetyl-sn-glycerol:CDP-choline cholinephosphotransferase
J. Biol. Chem.
266
21358-21361
1991
Homo sapiens
brenda
Tsoukatos, D.C.; Tselepis, A.D.; Lekka, M.E.
Studies on the subcellular distribution of 1-O-alkyl-2-acetyl-sn-glycero phosphocholine (PAF) and on the enzymic activities involved in its biosynthesis within the ciliate Tetrahymena pyriformis
Biochim. Biophys. Acta
1170
258-264
1993
Tetrahymena pyriformis
brenda
Ishidate, K.; Matsuo, R.; Nakazawa, Y.
CDPcholine:1,2-diacylglycerol cholinephosphotransferase from rat liver microsomes. I. Solubilization and characterization of the partially purified enzyme and the possible existence of an endogenous inhibitor
Lipids
28
89-96
1993
Rattus norvegicus
brenda
O, K.; Choy, P.C.
Solubilization and partial purification of cholinephosphotransferase in hamster tissues
Lipids
25
122-124
1990
Mesocricetus auratus
brenda
Mantel, C.R.; Schulz, A.R.; Miyazawa, K.; Broxmeyer, H.E.
Kinetic selectivity of cholinephosphotransferase in mouse liver: the Km for CDP-choline depends on diacylglycerol structure
Biochem. J.
289
815-820
1993
Mus musculus
-
brenda
Bru, R.; Blchliger, E.; Luisi, P.L.
sn-1,2-Diacylglycerol cholinephosphotransferase from pig liver: mixed micellar assay and kinetic analysis of the partially pure enzyme
Arch. Biochem. Biophys.
307
295-303
1993
Sus scrofa
brenda
Goracci, G.; Francescangeli, E.; Horrocks, L.A.; Porcellati, G.
The reverse reaction of cholinephosphotransferase in rat brain microsomes. A new pathway for degradation of phosphatidylcholine
Biochim. Biophys. Acta
664
373-379
1981
Rattus norvegicus
brenda
Pontoni, G.; Manna, C.; Salluzzo, A.; Del Piano, L.; Gallett, P.; De Rosa, M.; Zappia, V.
Studies on enzyme-substrate interactions of cholinephosphotransferase from rat liver
Biochim. Biophys. Acta
836
222-232
1985
Rattus norvegicus
brenda
Cornell, R.; MaxLennan, D.H.
Solubilization and reconstitution of cholinephosphotransferase from sarcoplasmic reticulum: stabilization of solubilized enzyme by diacylglycerol and glycerol
Biochim. Biophys. Acta
821
97-105
1985
Oryctolagus cuniculus
brenda
Wang, P.; Dechatelet, L.R.; Waite, M.
Enzymes of phospholipid synthesis in Bacillus Calmette-Guerin induced rabbit alveolar macrophage. Characterization and localization of cytidine diphosphocholine phosphotransferase and monoacylphospholipid acyltransferase
Biochim. Biophys. Acta
450
311-321
1976
Oryctolagus cuniculus
brenda
Baker, R.R.; Chang, H.Y.
Cholinephosphotransferase activities in microsomes and neuronal nuclei isolated from immature rabbit cerebral cortex: the use of endogenously generated diacylglycerols as substrate
Can. J. Biochem.
60
724-733
1982
Oryctolagus cuniculus
brenda
Kanoh, H.; Ohno, K.
1,2-Diacylglycerol: CDPcholine cholinephosphotransferase
Methods Enzymol.
71
536-546
1981
Rattus norvegicus
-
brenda
Dorman, R.V.; Bischoff, S.B.; Terrian, D.M.
Choline and ethanolamine phosphotransferase activities in glomerular particles isolated from bovine cerebellar cortex
Neurochem. Res.
11
1167-1179
1986
Bos taurus
brenda
Binaglia, L.; Roberti, R.; Vecchini, A.; De Meo, G.; Porcellati, G.
Temperature-dependence of choline phosphotransferase and ethanolamine phosphotransferase in rat brain microsomes
Ital. J. Biochem.
29
43-45
1980
Rattus norvegicus
brenda
Sribney, M.; Lyman, E.M.
Stimulation of phosphorylcholine-glyceride transferase activity by unsaturated fatty acids
Can. J. Biochem.
51
1479-1486
1973
Gallus gallus
brenda
Hjelmstad, R.H.; Bell, R.M.
Choline- and ethanolaminephosphotransferases from Saccharomyces cerevisiae
Methods Enzymol.
209
272-279
1992
Saccharomyces cerevisiae
brenda
Justin, A.M.; Demandre, C.; Tremolieres, A.; Mazliak, P.
No discrimination by choline- and ethanolamine phosphotransferases from potato tuber microsomes in molecular species of endogenous diacylglycerols
Biochim. Biophys. Acta
836
1-7
1985
Solanum tuberosum
-
brenda
Goracci, G.; Francescangeli, E.; Horrocks, L.A.; Porcellati, G.
A comparison of the reversibility of phosphoethanolamine transferase and phosphocholine transferase in rat brain microsomes
Biochim. Biophys. Acta
876
387-391
1986
Rattus norvegicus
brenda
Taniguchi, S.; Morikawa, S.; Hayashi, H.; Fujii, K.; Mori, H.; Fujiwara, M.; Fujiwara, M.
Effects of Ca2+ on ethanolaminephosphotransferase and cholinephosphotransferase in rabbit platelets
J. Biochem.
100
485-491
1986
Oryctolagus cuniculus
brenda
Justin, A.M.; Demandre, C.; Mazliak, P.
Choline- and ethanolaminephosphotransferases from pea leaf and soya beans discriminate 1-palmitoyl-2-linoleoyldiacylglycerol as preferred substrate
Biochim. Biophys. Acta
922
364-371
1987
Glycine max, Pisum sativum
-
brenda
Smith, J.D.
Differential selectivity of cholinephosphotransferase and ethanolaminephosphotransferase of Tetrahymena for diacylglycerol and alkylacylglycerol
J. Biol. Chem.
260
2064-2068
1985
Tetrahymena thermophila
brenda
Hjelmstad, R.H.; Bell, R.M.
sn-1,2-Diacylglycerol choline- and ethanolaminephosphotransferases in Saccharomyces cerevisiae. Mixed micellar analysis of the CPT1 and EPT1 gene products
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