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Information on EC 2.9.1.2 - O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase

for references in articles please use BRENDA:EC2.9.1.2

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IUBMB Comments

A pyridoxal-phosphate protein . In archaea and eukarya selenocysteine formation is achieved by a two-step process: EC 2.7.1.164 (O-phosphoseryl-tRNASec kinase) phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase.

The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
  • 2.9.1.2
  • selenoproteins
  • autoantibodies
  • sec-trnasec
  • ama-m2
  • cerebello-cerebral
  • sep-trna:sec-trna
  • trna-dependent
  • anti-soluble
  • trnasersec
  • secisbp2
  • selenoproteome
  • efsec
  • anti-smooth
  • anti-liver
  • selenoenzymes
  • sephs2

Synonyms
sepsecs, sla/lp, o-phosphoseryl-trna:selenocysteinyl-trna synthase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
O-phospho-L-seryl-tRNASec + selenophosphate + H2O = L-selenocysteinyl-tRNASec + 2 phosphate
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
L-selenocysteine biosynthesis II (archaea and eukaryotes)
Highest Expressing Human Cell Lines
Cell Line Links Gene Links