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Information on EC 3.1.1.106 - O-acetyl-ADP-ribose deacetylase

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.106 O-acetyl-ADP-ribose deacetylase
IUBMB Comments
The enzyme, characterized from the bacterium Escherichia coli and from human cells, removes the acetyl group from either the 2'' or 3'' position of O-acetyl-ADP-ribose, which are formed by the action of EC 2.3.1.286, protein acetyllysine N-acetyltransferase. The human enzyme can also remove ADP-D-ribose from phosphorylated double stranded DNA adducts.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
macrod2, macrod1, c6orf130, adp-ribosyl hydrolase, macrodomain 1, oaadpr hydrolase, o-acetyl-adp-ribose deacetylase, macrod-like protein, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2''-O-acetyl-ADP-D-ribose + H2O = ADP-D-ribose + acetate
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(2)
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3''-O-acetyl-ADP-D-ribose + H2O = ADP-D-ribose + acetate
show the reaction diagram
(1)
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