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(25R)-3beta-hydroxycholest-5-en-27-oate + H2O
?
-
-
-
-
?
2-(diethylamino)-4H-3,1-benzoxazin-4-one + H2O
?
-
-
-
?
2-(diethylamino)-4H-thieno[2,3-d][1,3]oxazin-4-one + H2O
?
-
-
-
?
2-(diethylamino)-4H-thieno[2,3-d][1,3]thiazin-4-one + H2O
?
-
-
-
?
2-(diethylamino)-5,6,7,8-tetrahydro-4H-[1]benzothieno[2,3-d][1,3]oxazin-4-one + H2O
?
-
-
-
?
2-(diethylamino)-6,7-dihydro-4H,5H-cyclopenta[4,5]thieno[2,3-d][1,3]oxazin-4-one + H2O
?
-
-
-
?
2-(diethylamino)-6,7-dihydro-4H,5H-cyclopenta[4,5]thieno[2,3-d][1,3]thiazin-4-one + H2O
?
-
-
-
?
2-(dimethylamino)-1,5,6,7-tetrahydro-2H,4H-cyclopenta(4,5)thieno(2,3-d)(1,3)oxazin-4-one + H2O
?
-
-
-
-
?
4-methylumbelliferyl butyrate + H2O
4-methylumbelliferol + butyrate
4-methylumbelliferyl oleate + H2O
4-methylumbelliferol + oleate
-
-
-
-
?
4-methylumbelliferyl oleate + H2O
4-methylumbelliferone + oleic acid
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
4-nitrophenyl myristate + H2O
4-nitrophenol + myristate
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
acylglycerols + H2O
? + fatty acids
-
-
-
?
bis(2-ethylhexyl) phthalate + H2O
mono(2-ethylhexyl)phthalate + ?
cholesterol + oleate
cholesteryl oleate + H2O
-
100% esterification with 50 units of enzyme after 20 h. The enzyme is largely independent of water content in the synthesis of cholesteryl oleate, and it achieves near-complete esterification in the presence of an equimolar excess of oleate
-
-
?
cholesterol acetate + H2O
cholesterol + acetic acid
cholesterol butyrate + H2O
cholesterol + butyric acid
cholesterol decanoate + H2O
cholesterol + decanoic acid
cholesterol ester + H2O
cholesterol + fatty acid
-
hydrolysis level greatly exceeds the synthesis level, enzyme can simultaneously perform synthesis and hydrolysis reactions
-
r
cholesterol hexanoate + H2O
cholesterol + hexanoic acid
29% of the activity with cholesteryl linoleate
-
-
?
cholesterol linoleate + H2O
cholesterol + linoleic acid
-
-
-
?
cholesterol oleate + H2O
cholesterol + oleic acid
cholesterol palmitate + H2O
cholesterol + palmitic acid
5% of the activity with cholesteryl linoleate
-
-
?
cholesteryl acetate + H2O
cholesterol + acetate
cholesteryl acetate + H2O
cholesterol + acetic acid
cholesteryl arachidonate + H2O
cholesterol + arachidonic acid
cholesteryl butyrate + H2O
cholesterol + butanoic acid
cholesteryl butyrate + H2O
cholesterol + butyrate
cholesteryl caprate + H2O
cholesterol + caprate
cholesteryl caprinate + H2O
cholesterol + caprinate
-
-
-
?
cholesteryl caproate + H2O
cholesterol + caproate
cholesteryl caprylate + H2O
cholesterol + caprylate
cholesteryl caprylate + H2O
cholesterol + caprylic acid
-
-
-
?
cholesteryl decanoate + H2O
cholesterol + decanoate
-
-
-
-
?
cholesteryl eicosenoate + H2O
cholesterol + eicosenoic acid
cholesteryl elaidate + H2O
cholesterol + elaidate
-
-
-
?
cholesteryl erucate + H2O
cholesterol + erucic acid
cholesteryl esters + H2O
cholesterol + fatty acid
cholesteryl hexanoate + H2O
cholesterol + hexanoate
-
-
-
-
?
cholesteryl laurate + H2O
cholesterol + laurate
cholesteryl laurate + H2O
cholesterol + lauric acid
cholesteryl linoleate + H2O
cholesterol + linoleate
cholesteryl linoleate + H2O
cholesterol + linoleic acid
cholesteryl linolenate + H2O
cholesterol + linolenic acid
cholesteryl myristate + H2O
cholesterol + myristate
cholesteryl myristate + H2O
cholesterol + myristic acid
cholesteryl nervonate + H2O
cholesterol + nervonic acid
cholesteryl oleate
cholesterol + oleate
cholesteryl oleate + H2O
cholesterol + oleate
cholesteryl oleate + H2O
cholesterol + oleic acid
cholesteryl palmitate + H2O
cholesterol + palmitate
cholesteryl palmitate + H2O
cholesterol + palmitic acid
cholesteryl propionate + H2O
cholesterol + propionate
cholesteryl stearate + H2O
cholesterol + stearate
cholesteryl stearate + H2O
cholesterol + stearic acid
cholesteryl valerate + H2O
cholesterol + valeric acid
-
-
-
?
di-n-butyl phthalate + H2O
?
di-n-hexyl phthalate + H2O
?
di-n-pentyl phthalate + H2O
?
di-n-propyl phthalate + H2O
?
dicyclohexyl phthalate + H2O
?
diethyl phthalate + H2O
?
diolein + H2O
monooleoylglycerol + oleic acid
-
-
-
?
fat-soluble vitamin esters + H2O
vitamin + ?
lipoyl 4-aminobenzoate + H2O
4-aminobenzoate + lipoic acid
monoolein + H2O
glycerol + oleic acid
-
-
-
?
monooleoylalkylglycerol + H2O
alkylglycerol + oleic acid
-
-
-
?
n-butyl benzyl phthalate + H2O
?
nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
-
-
-
?
oleic acid + cholesterol
cholesteryl oleate
-
-
-
r
oleic acid + retinol
retinyl oleate
-
-
-
r
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
p-nitrophenyl acetate + H2O
p-nitrophenol + acetic acid
p-nitrophenyl butyrate + H2O
p-nitrophenol + butanoic acid
p-nitrophenyl butyrate + H2O
p-nitrophenol + butyrate
p-nitrophenyl caproate + H2O
p-nitrophenol + capric acid
-
-
-
-
?
p-nitrophenyl caprylate + H2O
p-nitrophenol + caprylic acid
-
activity increases with more lipophilic substrates
-
?
p-nitrophenyl hexanoate + H2O
p-nitrophenol + hexanoic acid
p-nitrophenyl laurate + H2O
p-nitrophenol + laurate
-
-
-
-
?
p-nitrophenyl laurate + H2O
p-nitrophenol + lauric acid
92% of the activity with cholesteryl linoleate
-
-
?
p-nitrophenyl myristate + H2O
p-nitrophenol + myristic acid
p-nitrophenyl octanoate + H2O
p-nitrophenol + octanoic acid
p-nitrophenyl palmitate + H2O
p-nitrophenol + palmitic acid
p-nitrophenyl propionate + H2O
p-nitrophenol + propionic acid
17% of the activity with cholesteryl linoleate
-
-
?
p-nitrophenyl stearate + H2O
p-nitrophenol + stearic acid
38% of the activity with cholesteryl linoleate
-
-
?
p-nitrophenyllactate + H2O
p-nitrophenol + lactic acid
-
-
-
?
p-nitrophenylmyristate + H2O
p-nitrophenol + myristic acid
-
-
-
?
palmityl oleate + H2O
palmitol + oleate
retinyl palmitate + H2O
retinol + palmitate
-
-
-
r
sitosterol oleate + H2O
sitosterol + oleate
-
about 60% activity compared to cholesteryl oleate
-
-
?
sitosterol palmitate + H2O
sitosterol + palmitate
-
about 30% activity compared to cholesteryl oleate
-
-
?
sitosterol stearate + H2O
sitosterol + stearate
-
about 30% activity compared to cholesteryl oleate
-
-
?
stigmastanol oleate + H2O
stigmastanol + oleate
-
about 65% activity compared to cholesteryl oleate
-
-
?
stigmastanol palmitate + H2O
stigmastanol + palmitate
-
about 30% activity compared to cholesteryl oleate
-
-
?
stigmastanol stearate + H2O
stigmastanol + stearate
-
about 20% activity compared to cholesteryl oleate
-
-
?
stigmasterol + stearate
stigmasteryl stearate + H2O
-
-
-
-
?
stigmasterol oleate + H2O
stigmasterol + oleate
-
about 35% activity compared to cholesteryl oleate
-
-
?
stigmasterol palmitate + H2O
stigmasterol + palmitate
-
about 15% activity compared to cholesteryl oleate
-
-
?
stigmasterol stearate + H2O
stigmasterol + stearate
-
about 15% activity compared to cholesteryl oleate
-
-
?
stigmasteryl oleate + H2O
stigmasterol + oleate
-
-
-
-
?
tocopherol acetate + H2O
tocopherol + acetate
-
-
-
r
triacetin + H2O
? + acetic acid
triacylglycerol + H2O
diacylglycerol + carboxylic acid
-
-
-
?
tributyrin + H2O
dibutyrin + butyrate
tributyrin + H2O
dibutyrylglycerol + butanoic acid
-
-
-
?
triolein + H2O
diolein + oleate
triolein + H2O
dioleoylglycerol + oleic acid
additional information
?
-
4-methylumbelliferyl butyrate + H2O
4-methylumbelliferol + butyrate
-
-
-
?
4-methylumbelliferyl butyrate + H2O
4-methylumbelliferol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
-
?
4-nitrophenyl myristate + H2O
4-nitrophenol + myristate
-
-
-
?
4-nitrophenyl myristate + H2O
4-nitrophenol + myristate
-
-
-
-
?
4-nitrophenyl myristate + H2O
4-nitrophenol + myristate
-
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
-
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
-
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
-
-
?
bis(2-ethylhexyl) phthalate + H2O
mono(2-ethylhexyl)phthalate + ?
-
complete hydrolysis within 15 min
-
-
?
bis(2-ethylhexyl) phthalate + H2O
mono(2-ethylhexyl)phthalate + ?
-
complete hydrolysis within 15 min
-
-
?
cholesterol acetate + H2O
cholesterol + acetic acid
3% of the activity with cholesteryl linoleate
-
-
?
cholesterol acetate + H2O
cholesterol + acetic acid
3% of the activity with cholesteryl linoleate
-
-
?
cholesterol butyrate + H2O
cholesterol + butyric acid
18% of the activity with cholesteryl linoleate
-
-
?
cholesterol butyrate + H2O
cholesterol + butyric acid
18% of the activity with cholesteryl linoleate
-
-
?
cholesterol decanoate + H2O
cholesterol + decanoic acid
34% of the activity with cholesteryl linoleate
-
-
?
cholesterol decanoate + H2O
cholesterol + decanoic acid
34% of the activity with cholesteryl linoleate
-
-
?
cholesterol oleate + H2O
cholesterol + oleic acid
53% of the activity with cholesteryl linoleate
-
-
?
cholesterol oleate + H2O
cholesterol + oleic acid
53% of the activity with cholesteryl linoleate
-
-
?
cholesteryl acetate + H2O
cholesterol + acetate
-
-
-
-
?
cholesteryl acetate + H2O
cholesterol + acetate
-
-
-
-
?
cholesteryl acetate + H2O
cholesterol + acetate
-
-
-
?
cholesteryl acetate + H2O
cholesterol + acetate
-
-
-
?
cholesteryl acetate + H2O
cholesterol + acetate
-
low activity, 6% of the activity with cholesteryl linoleate
-
?
cholesteryl acetate + H2O
cholesterol + acetate
-
-
-
?
cholesteryl acetate + H2O
cholesterol + acetate
-
-
-
?
cholesteryl acetate + H2O
cholesterol + acetate
-
-
-
-
?
cholesteryl acetate + H2O
cholesterol + acetate
-
-
-
-
?
cholesteryl acetate + H2O
cholesterol + acetate
-
-
-
?
cholesteryl acetate + H2O
cholesterol + acetate
-
-
-
?
cholesteryl acetate + H2O
cholesterol + acetate
-
-
-
-
?
cholesteryl acetate + H2O
cholesterol + acetate
-
-
-
-
?
cholesteryl acetate + H2O
cholesterol + acetate
-
9% activity compared to linoleate
-
-
?
cholesteryl acetate + H2O
cholesterol + acetate
-
-
-
-
?
cholesteryl acetate + H2O
cholesterol + acetate
-
9% activity compared to linoleate
-
-
?
cholesteryl acetate + H2O
cholesterol + acetic acid
-
-
-
?
cholesteryl acetate + H2O
cholesterol + acetic acid
-
very slowly hydrolyzed by acid cholesterol esterase, only hydrolyzed by neutral cholestrol esterase at pH 8.0
-
?
cholesteryl acetate + H2O
cholesterol + acetic acid
-
-
-
-
?
cholesteryl arachidonate + H2O
cholesterol + arachidonic acid
-
-
-
?
cholesteryl arachidonate + H2O
cholesterol + arachidonic acid
-
-
-
?
cholesteryl butyrate + H2O
cholesterol + butanoic acid
-
-
-
?
cholesteryl butyrate + H2O
cholesterol + butanoic acid
-
very slowly hydrolyzed by acid cholesterol esterase, only hydrolyzed by neutral cholesterol esterase at pH 8.0
-
?
cholesteryl butyrate + H2O
cholesterol + butyrate
-
-
-
-
?
cholesteryl butyrate + H2O
cholesterol + butyrate
-
-
-
?
cholesteryl butyrate + H2O
cholesterol + butyrate
-
low activity, 8% of the activity with cholesteryl linoleate
-
?
cholesteryl butyrate + H2O
cholesterol + butyrate
-
-
-
-
?
cholesteryl butyrate + H2O
cholesterol + butyrate
-
121% activity compared to linoleate
-
-
?
cholesteryl caprate + H2O
cholesterol + caprate
-
40% of the activity with cholesteryl linoleate
-
?
cholesteryl caprate + H2O
cholesterol + caprate
-
-
-
-
?
cholesteryl caprate + H2O
cholesterol + caprate
-
21% activity compared to linoleate
-
-
?
cholesteryl caproate + H2O
cholesterol + caproate
-
-
-
-
?
cholesteryl caproate + H2O
cholesterol + caproate
-
-
-
?
cholesteryl caproate + H2O
cholesterol + caproate
-
22% of the activity with cholesteryl linoleate
-
?
cholesteryl caproate + H2O
cholesterol + caproate
-
-
-
-
?
cholesteryl caproate + H2O
cholesterol + caproate
-
37% activity compared to linoleate
-
-
?
cholesteryl caprylate + H2O
cholesterol + caprylate
-
62% of the activity with cholesteryl linoleate
-
?
cholesteryl caprylate + H2O
cholesterol + caprylate
-
-
-
-
?
cholesteryl caprylate + H2O
cholesterol + caprylate
-
79% activity compared to linoleate
-
-
?
cholesteryl eicosenoate + H2O
cholesterol + eicosenoic acid
-
-
-
?
cholesteryl eicosenoate + H2O
cholesterol + eicosenoic acid
-
-
-
?
cholesteryl erucate + H2O
cholesterol + erucic acid
-
-
13-docosenoic acid
?
cholesteryl erucate + H2O
cholesterol + erucic acid
-
-
13-docosenoic acid
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
-
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
-
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
important rate-limiting step in steroidogenesis
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
important rate-limiting step in steroidogenesis
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
important rate-limiting step in steroidogenesis
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
supplies free cholesterol as a precursor for steroidogenesis in steroid-producing tissues
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
supplies free cholesterol as a precursor for steroidogenesis in steroid-producing tissues
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
involvement in arteriosclerosis
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
-
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
-
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
shows also lipoamidase activity
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
acid cholesterol esterase hydrolized only long-chain cholesteryl esters, activity is low for substrate concentration below the critical micelle concentration
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
mediating cholesterol absorption through the gastrointestinal tract, digestion and absorption of dietary fats
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
important role in fat digestion in infants
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
important role in fat digestion in infants
-
r
cholesteryl esters + H2O
cholesterol + fatty acid
-
involvement in arteriosclerosis
-
r
cholesteryl esters + H2O
cholesterol + fatty acid
-
-
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
-
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
involvement in arteriosclerosis
-
r
cholesteryl esters + H2O
cholesterol + fatty acid
-
-
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
-
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
important rate-limiting step in steroidogenesis
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
long-chain fatty acid cholesterol esters more easily synthesized, synthetic activity highest in chloroform, activity enhanced in degree of unsaturation of fatty acids
-
r
cholesteryl esters + H2O
cholesterol + fatty acid
-
-
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
-
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
-
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
-
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
-
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
-
-
ir
cholesteryl esters + H2O
cholesterol + fatty acid
-
-
-
r
cholesteryl esters + H2O
cholesterol + fatty acid
-
shows also lipoamidase activity
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
mediating cholesterol absorption through the gastrointestinal tract, digestion and absorption of dietary fats
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
mediating cholesterol absorption through the gastrointestinal tract, digestion and absorption of dietary fats
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
involvement in inhibition of spermatogenesis
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
involvement in inhibition of spermatogenesis
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
fatty acid binding site more hydrophobic than steroid binding site
-
r
cholesteryl esters + H2O
cholesterol + fatty acid
-
important role in fat digestion in infants
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
important role in fat digestion in infants
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
important role in fat digestion in infants
-
r
cholesteryl esters + H2O
cholesterol + fatty acid
-
involvement in arteriosclerosis
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
involvement in arteriosclerosis
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
involvement in arteriosclerosis
-
r
cholesteryl esters + H2O
cholesterol + fatty acid
-
involvement in arteriosclerosis
-
r
cholesteryl esters + H2O
cholesterol + fatty acid
-
hydrolytic activity toward liposomal and microcrystallic substrates
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
-
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
-
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
-
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
-
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
-
-
?
cholesteryl esters + H2O
cholesterol + fatty acid
-
absoprtion of free cholesterol
-
r
cholesteryl esters + H2O
cholesterol + fatty acid
-
fatty acid binding site more hydrophobic than steroid binding site
-
r
cholesteryl esters + H2O
cholesterol + fatty acid
-
important role in fat digestion in infants
-
r
cholesteryl laurate + H2O
cholesterol + laurate
-
-
-
-
?
cholesteryl laurate + H2O
cholesterol + laurate
-
41% of the activity with cholesteryl linoleate
-
?
cholesteryl laurate + H2O
cholesterol + laurate
-
-
-
-
?
cholesteryl laurate + H2O
cholesterol + laurate
-
35% activity compared to linoleate
-
-
?
cholesteryl laurate + H2O
cholesterol + lauric acid
-
-
-
?
cholesteryl laurate + H2O
cholesterol + lauric acid
-
-
-
r
cholesteryl linoleate + H2O
cholesterol + linoleate
-
best substrate
-
-
?
cholesteryl linoleate + H2O
cholesterol + linoleate
-
best substrate
-
-
?
cholesteryl linoleate + H2O
cholesterol + linoleate
-
best substrate
-
?
cholesteryl linoleate + H2O
cholesterol + linoleate
-
-
-
-
?
cholesteryl linoleate + H2O
cholesterol + linoleate
-
-
-
?
cholesteryl linoleate + H2O
cholesterol + linoleate
-
best substrate
-
?
cholesteryl linoleate + H2O
cholesterol + linoleate
-
-
-
?
cholesteryl linoleate + H2O
cholesterol + linoleate
-
-
-
?
cholesteryl linoleate + H2O
cholesterol + linoleate
-
-
-
-
?
cholesteryl linoleate + H2O
cholesterol + linoleate
-
-
-
-
?
cholesteryl linoleate + H2O
cholesterol + linoleate
-
-
-
?
cholesteryl linoleate + H2O
cholesterol + linoleate
-
-
-
?
cholesteryl linoleate + H2O
cholesterol + linoleate
-
-
-
-
?
cholesteryl linoleate + H2O
cholesterol + linoleate
-
100% activity
-
-
?
cholesteryl linoleate + H2O
cholesterol + linoleate
-
100% activity
-
-
?
cholesteryl linoleate + H2O
cholesterol + linoleic acid
-
-
-
-
?
cholesteryl linoleate + H2O
cholesterol + linoleic acid
-
-
-
-
?
cholesteryl linoleate + H2O
cholesterol + linoleic acid
-
most suitable substrate
-
?
cholesteryl linoleate + H2O
cholesterol + linoleic acid
-
-
-
?
cholesteryl linoleate + H2O
cholesterol + linoleic acid
-
-
-
-
?
cholesteryl linoleate + H2O
cholesterol + linoleic acid
-
synthesis of cholesterol linoleate from polyethylene glycol-modified enzyme only in water-immiscible solvents
-
r
cholesteryl linoleate + H2O
cholesterol + linoleic acid
-
activity lower than with oleate esters
-
r
cholesteryl linoleate + H2O
cholesterol + linoleic acid
-
-
-
-
?
cholesteryl linoleate + H2O
cholesterol + linoleic acid
-
-
-
-
?
cholesteryl linolenate + H2O
cholesterol + linolenic acid
-
-
-
-
?
cholesteryl linolenate + H2O
cholesterol + linolenic acid
-
-
-
-
?
cholesteryl linolenate + H2O
cholesterol + linolenic acid
-
-
-
-
?
cholesteryl myristate + H2O
cholesterol + myristate
-
58% of the activity with cholesteryl linoleate
-
?
cholesteryl myristate + H2O
cholesterol + myristate
-
-
-
?
cholesteryl myristate + H2O
cholesterol + myristate
-
-
-
-
?
cholesteryl myristate + H2O
cholesterol + myristate
-
-
-
?
cholesteryl myristate + H2O
cholesterol + myristate
-
-
-
-
?
cholesteryl myristate + H2O
cholesterol + myristate
-
42% activity compared to linoleate
-
-
?
cholesteryl myristate + H2O
cholesterol + myristic acid
-
-
-
r
cholesteryl myristate + H2O
cholesterol + myristic acid
-
-
-
-
?
cholesteryl myristate + H2O
cholesterol + myristic acid
-
-
-
-
?
cholesteryl nervonate + H2O
cholesterol + nervonic acid
-
especially for temperature-labile cholesteryl esterase
-
?
cholesteryl nervonate + H2O
cholesterol + nervonic acid
-
-
-
?
cholesteryl oleate
cholesterol + oleate
-
-
-
?
cholesteryl oleate
cholesterol + oleate
-
-
-
?
cholesteryl oleate
cholesterol + oleate
-
the cholesterol which is incorporated into brush border membrane is not esterified
-
?
cholesteryl oleate
cholesterol + oleate
-
-
-
?
cholesteryl oleate
cholesterol + oleate
-
the cholesterol which is incorporated into brush border membrane is not esterified
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
92% of the activity with cholesteryl linoleate
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
100% activity, best substrate
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
21% activity compared to linoleate
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
21% activity compared to linoleate
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
r
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
r
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
r
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
ir
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
r
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
r
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
r
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
r
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
r
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
ir
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
r
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
r
cholesteryl palmitate + H2O
cholesterol + palmitate
-
-
-
-
?
cholesteryl palmitate + H2O
cholesterol + palmitate
-
-
-
-
?
cholesteryl palmitate + H2O
cholesterol + palmitate
-
-
-
?
cholesteryl palmitate + H2O
cholesterol + palmitate
-
-
-
?
cholesteryl palmitate + H2O
cholesterol + palmitate
-
75% of the activity with cholesteryl linoleate
-
?
cholesteryl palmitate + H2O
cholesterol + palmitate
-
-
-
?
cholesteryl palmitate + H2O
cholesterol + palmitate
-
-
-
?
cholesteryl palmitate + H2O
cholesterol + palmitate
-
-
-
-
?
cholesteryl palmitate + H2O
cholesterol + palmitate
-
-
-
-
?
cholesteryl palmitate + H2O
cholesterol + palmitate
-
-
-
?
cholesteryl palmitate + H2O
cholesterol + palmitate
-
-
-
?
cholesteryl palmitate + H2O
cholesterol + palmitate
-
about 50% activity compared to cholesteryl oleate
-
-
?
cholesteryl palmitate + H2O
cholesterol + palmitate
-
-
-
-
?
cholesteryl palmitate + H2O
cholesterol + palmitate
-
38% activity compared to linoleate
-
-
?
cholesteryl palmitate + H2O
cholesterol + palmitate
-
-
-
-
?
cholesteryl palmitate + H2O
cholesterol + palmitate
-
38% activity compared to linoleate
-
-
?
cholesteryl palmitate + H2O
cholesterol + palmitic acid
-
-
-
-
?
cholesteryl palmitate + H2O
cholesterol + palmitic acid
-
-
-
-
?
cholesteryl palmitate + H2O
cholesterol + palmitic acid
-
low activity
-
?
cholesteryl palmitate + H2O
cholesterol + palmitic acid
-
-
-
-
?
cholesteryl palmitate + H2O
cholesterol + palmitic acid
-
-
-
r
cholesteryl palmitate + H2O
cholesterol + palmitic acid
-
-
-
-
?
cholesteryl palmitate + H2O
cholesterol + palmitic acid
-
-
-
-
?
cholesteryl propionate + H2O
cholesterol + propionate
-
-
-
?
cholesteryl propionate + H2O
cholesterol + propionate
-
-
-
-
?
cholesteryl stearate + H2O
cholesterol + stearate
-
-
-
?
cholesteryl stearate + H2O
cholesterol + stearate
-
-
-
?
cholesteryl stearate + H2O
cholesterol + stearate
-
80% of the activity with cholesteryl linoleate
-
?
cholesteryl stearate + H2O
cholesterol + stearate
-
-
-
?
cholesteryl stearate + H2O
cholesterol + stearate
-
-
-
-
?
cholesteryl stearate + H2O
cholesterol + stearate
-
-
-
?
cholesteryl stearate + H2O
cholesterol + stearate
-
about 45% activity compared to cholesteryl oleate
-
-
?
cholesteryl stearate + H2O
cholesterol + stearate
-
-
-
-
?
cholesteryl stearate + H2O
cholesterol + stearate
-
18% activity compared to linoleate
-
-
?
cholesteryl stearate + H2O
cholesterol + stearate
-
-
-
-
?
cholesteryl stearate + H2O
cholesterol + stearic acid
-
-
-
-
?
cholesteryl stearate + H2O
cholesterol + stearic acid
-
-
-
-
?
cholesteryl stearate + H2O
cholesterol + stearic acid
-
-
-
-
?
cholesteryl stearate + H2O
cholesterol + stearic acid
-
-
-
r
cholesteryl stearate + H2O
cholesterol + stearic acid
-
-
-
?
cholesteryl stearate + H2O
cholesterol + stearic acid
-
-
-
-
?
cholesteryl stearate + H2O
cholesterol + stearic acid
-
-
-
-
?
cholesteryl stearate + H2O
cholesterol + stearic acid
-
-
-
?
di-n-butyl phthalate + H2O
?
-
complete hydrolysis within 15 min
-
-
?
di-n-butyl phthalate + H2O
?
-
complete hydrolysis within 15 min
-
-
?
di-n-hexyl phthalate + H2O
?
-
complete hydrolysis within 15 min
-
-
?
di-n-hexyl phthalate + H2O
?
-
complete hydrolysis within 15 min
-
-
?
di-n-pentyl phthalate + H2O
?
-
complete hydrolysis within 15 min
-
-
?
di-n-pentyl phthalate + H2O
?
-
complete hydrolysis within 15 min
-
-
?
di-n-propyl phthalate + H2O
?
-
complete hydrolysis within 15 min
-
-
?
di-n-propyl phthalate + H2O
?
-
complete hydrolysis within 15 min
-
-
?
dicyclohexyl phthalate + H2O
?
-
complete hydrolysis within 6 h
-
-
?
dicyclohexyl phthalate + H2O
?
-
complete hydrolysis within 6 h
-
-
?
diethyl phthalate + H2O
?
-
complete hydrolysis within 15 min
-
-
?
diethyl phthalate + H2O
?
-
complete hydrolysis within 15 min
-
-
?
fat-soluble vitamin esters + H2O
vitamin + ?
-
-
-
?
fat-soluble vitamin esters + H2O
vitamin + ?
-
-
-
?
fat-soluble vitamin esters + H2O
vitamin + ?
-
-
-
?
lipoyl 4-aminobenzoate + H2O
4-aminobenzoate + lipoic acid
-
-
-
?
lipoyl 4-aminobenzoate + H2O
4-aminobenzoate + lipoic acid
-
-
-
?
n-butyl benzyl phthalate + H2O
?
-
complete hydrolysis within 30 min
-
-
?
n-butyl benzyl phthalate + H2O
?
-
complete hydrolysis within 30 min
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
5% of the activity with cholesteryl linoleate
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
5% of the activity with cholesteryl linoleate
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
-
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
-
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetic acid
-
-
-
r
p-nitrophenyl acetate + H2O
p-nitrophenol + acetic acid
-
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetic acid
-
-
-
r
p-nitrophenyl acetate + H2O
p-nitrophenol + acetic acid
-
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetic acid
-
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetic acid
-
low activity
-
r
p-nitrophenyl acetate + H2O
p-nitrophenol + acetic acid
-
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetic acid
-
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetic acid
-
-
-
ir
p-nitrophenyl butyrate + H2O
p-nitrophenol + butanoic acid
-
-
-
?
p-nitrophenyl butyrate + H2O
p-nitrophenol + butanoic acid
-
-
-
?
p-nitrophenyl butyrate + H2O
p-nitrophenol + butanoic acid
-
-
-
?
p-nitrophenyl butyrate + H2O
p-nitrophenol + butanoic acid
-
-
-
?
p-nitrophenyl butyrate + H2O
p-nitrophenol + butanoic acid
-
-
-
?
p-nitrophenyl butyrate + H2O
p-nitrophenol + butanoic acid
-
-
-
?
p-nitrophenyl butyrate + H2O
p-nitrophenol + butanoic acid
-
-
-
?
p-nitrophenyl butyrate + H2O
p-nitrophenol + butanoic acid
-
-
-
?
p-nitrophenyl butyrate + H2O
p-nitrophenol + butanoic acid
-
-
-
?
p-nitrophenyl butyrate + H2O
p-nitrophenol + butanoic acid
-
-
-
?
p-nitrophenyl butyrate + H2O
p-nitrophenol + butanoic acid
-
-
-
r
p-nitrophenyl butyrate + H2O
p-nitrophenol + butyrate
-
-
-
-
?
p-nitrophenyl butyrate + H2O
p-nitrophenol + butyrate
-
-
-
-
?
p-nitrophenyl hexanoate + H2O
p-nitrophenol + hexanoic acid
53% of the activity with cholesteryl linoleate
-
-
?
p-nitrophenyl hexanoate + H2O
p-nitrophenol + hexanoic acid
-
-
-
-
?
p-nitrophenyl myristate + H2O
p-nitrophenol + myristic acid
100% of the activity with cholesteryl linoleate
-
-
?
p-nitrophenyl myristate + H2O
p-nitrophenol + myristic acid
-
-
-
-
?
p-nitrophenyl octanoate + H2O
p-nitrophenol + octanoic acid
79% of the activity with cholesteryl linoleate
-
-
?
p-nitrophenyl octanoate + H2O
p-nitrophenol + octanoic acid
-
-
-
-
?
p-nitrophenyl palmitate + H2O
p-nitrophenol + palmitic acid
68% of the activity with cholesteryl linoleate
-
-
?
p-nitrophenyl palmitate + H2O
p-nitrophenol + palmitic acid
-
-
-
?
p-nitrophenyl palmitate + H2O
p-nitrophenol + palmitic acid
-
-
-
-
?
palmityl oleate + H2O
palmitol + oleate
-
-
-
-
?
palmityl oleate + H2O
palmitol + oleate
-
-
-
-
?
triacetin + H2O
? + acetic acid
-
-
-
?
triacetin + H2O
? + acetic acid
-
-
-
?
tributyrin + H2O
dibutyrin + butyrate
-
-
-
?
tributyrin + H2O
dibutyrin + butyrate
-
-
-
?
triolein + H2O
diolein + oleate
-
-
-
-
?
triolein + H2O
diolein + oleate
-
-
-
?
triolein + H2O
diolein + oleate
-
best substrate
-
?
triolein + H2O
diolein + oleate
-
positional specificity for sn-2-position, lower affinity for the sn-1- and sn-3-position
-
?
triolein + H2O
diolein + oleate
-
-
-
-
?
triolein + H2O
dioleoylglycerol + oleic acid
-
-
-
?
triolein + H2O
dioleoylglycerol + oleic acid
-
-
-
?
triolein + H2O
dioleoylglycerol + oleic acid
-
-
-
?
triolein + H2O
dioleoylglycerol + oleic acid
-
-
-
?
triolein + H2O
dioleoylglycerol + oleic acid
-
-
-
?
triolein + H2O
dioleoylglycerol + oleic acid
-
-
-
r
triolein + H2O
dioleoylglycerol + oleic acid
-
-
-
?
triolein + H2O
dioleoylglycerol + oleic acid
-
-
-
r
triolein + H2O
dioleoylglycerol + oleic acid
-
-
-
?
triolein + H2O
dioleoylglycerol + oleic acid
-
-
-
?
triolein + H2O
dioleoylglycerol + oleic acid
-
-
-
?
triolein + H2O
dioleoylglycerol + oleic acid
-
-
-
r
additional information
?
-
-
rank of the relative rates of hydrolysis by Acinetobacter sp. strain CHE4-1 enzyme are linoleate > oleate > acetate > palmitate > butyrate > laurate > caproate
-
-
?
additional information
?
-
-
rank of the relative rates of hydrolysis by Acinetobacter sp. strain CHE4-1 enzyme are linoleate > oleate > acetate > palmitate > butyrate > laurate > caproate
-
-
?
additional information
?
-
-
enzyme is involved in fatty acid catabolism
-
?
additional information
?
-
-
the enzyme accelerates the incorporation of cholesterol into human adenocarcinomal Caco-2 cells, which is not influenced by addition of exogenous oleic acid, the enzyme also significantly increases the incorporation of cholesterol into the intestinal brush border membranes of rat
-
?
additional information
?
-
-
enzyme catalyzes cleavage of fatty acid residues in both the sn-1 and sn-2 positions of phospholipids
-
-
?
additional information
?
-
-
in aqueous dispersion, reaction proceeds slowly. Addition of surfactant Thesit accelerates initial reaction rate
-
-
?
additional information
?
-
-
the enzyme accelerates the incorporation of cholesterol into human adenocarcinomal Caco-2 cells, which is not influenced by addition of exogenous oleic acid
-
?
additional information
?
-
-
neutral lipid metabolism in macrophages contributes to organ inflammation and pathogenesis
-
-
?
additional information
?
-
-
neutral cholesterol ester hydrolase is not a target of protein kinase A
-
-
?
additional information
?
-
-
CRL1 slowly hydrolyzes 6-chloro-2-pyrones
-
?
additional information
?
-
-
enzyme prefers substrates of long-chain fatty acids and unsaturated fatty acids
-
?
additional information
?
-
-
no activity with triacetin, enzyme activity increases with increasing chain lebgth and number of double bonds, no interfacial activation
-
?
additional information
?
-
-
the enzyme does not hydrolyze bis(2-ethylhexyl) phthalate, diethyl phthalate, di-n-propyl phthalate, di-n-butyl phthalate, di-n-pentyl phthalate, di-n-hexyl phthalate, n-butyl benzyl phthalate and dicyclohexyl phthalate
-
-
?
additional information
?
-
-
the enzyme within the pancreatic juice significantly increased the incorporation of cholesterol into the intestinal brush border membranes of rat
-
?
additional information
?
-
-
the enzyme is also active on fatty acid esters of methanol and 4-nitrophenol
-
-
?
additional information
?
-
-
the enzyme catalyzes reactions between cholesterol and methyl oleate/triolein. The degree of esterification of cholesterol with methyl oleate is 31% at the most after 19 h. The use of triolein as acyl donor results in lower esterification
-
-
?
additional information
?
-
-
the hydrolytic activity of the enzyme increases from cholesterol acetate to caproate, then decreases sharply from caproate to caprate, with a further gradual decrease through stearate. In esterification there is virtually no activity with short-chain free fatty acids from acetate through caproate, a marked increase with caprylate, and a constant level from caprylate through stearate
-
-
?
additional information
?
-
-
the enzyme catalyzes reactions between cholesterol and methyl oleate/triolein. The degree of esterification of cholesterol with methyl oleate is 31% at the most after 19 h. The use of triolein as acyl donor results in lower esterification
-
-
?
additional information
?
-
-
the hydrolytic activity of the enzyme increases from cholesterol acetate to caproate, then decreases sharply from caproate to caprate, with a further gradual decrease through stearate. In esterification there is virtually no activity with short-chain free fatty acids from acetate through caproate, a marked increase with caprylate, and a constant level from caprylate through stearate
-
-
?
additional information
?
-
-
the enzyme is also active on fatty acid esters of methanol and 4-nitrophenol
-
-
?
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(+)-AS115
non-selective inhibitor
(-)-AS115
non-selective inhibitor
(1-ethoxy-7-methoxy-1-oxido-1H-2,1-benzoxaphosphinin-3-yl)methanol
-
-
(1R, alphaR)-2'-N-alpha-methylbenzylcarbamyl-1,1'-bi-2-naphthol
-
-
(1R, alphaS)-2'-N-alpha-methylbenzylcarbamyl-1,1'-bi-2-naphthol
-
-
(1S, alphaR)-2'-N-alpha-methylbenzylcarbamyl-1,1'-bi-2-naphthol
-
-
(1S, alphaS)-2'-N-alpha-methylbenzylcarbamyl-1,1'-bi-2-naphthol
-
-
(R)-2'-N-butylcarbamyl-1,1'-bi-naphthol
-
-
(R)-endo-2-norbornyl-N-n-butyl-carbamate
-
-
(R)-exo-2-norbornyl-N-n-butylcarbamate
-
the R-enantiomer is 6.8times more potent than the S-enantiomer
(S)-2'-N-butylcarbamyl-1,1'-bi-naphthol
-
-
(S)-endo-2-norbornyl-N-n-butyl-carbamate
-
the S-enantiomer is 4.6times more potent than the R-enantiomer
(S)-exo-2-norbornyl-N-n-butylcarbamate
-
-
1-ethoxy-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
-
-
1-ethoxy-3-phenyl-4-(phenylethynyl)-1H-2,1-benzoxaphosphinine 1-oxide
-
-
1-ethoxy-4-iodo-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
-
-
1-ethoxy-4-iodo-7-methoxy-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
-
-
1-ethoxy-7-methoxy-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
-
-
2'-[(phenylcarbamoyl)oxy]biphenyl-2-yl octadecylcarbamate
-
-
2-(1H-indol-3-yl)-6-nitro-4-phenylquinoline
-
competitive mixed-type inhibitor
2-(2,3-dichlorophenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(2,4-difluorophenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(2,4-dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(2,5-difluorophenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(2,6-difluorophenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(2-bromophenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(2-fluorophenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(2-iodophenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(3,4-difluorophenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one
-
-
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
-
-
2-(3,4-dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(3,5-difluorophenyl)-4H-naphtho[1,2-b]pyran-4-one
mixed-type inhibition. A-12 fits well in the catalytic site and is stabilized by hydrophobic interactions. It completely blocks the catalytic assembly of the enzyme and prevents it to participate in ester hydrolysis mechanism. The favorable binding confor
2-(3,5-dinitrophenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(3-bromophenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(3-bromophenyl)-6-chloro-4-phenylquinoline
-
-
2-(3-bromophenyl)-6-nitro-4-phenylquinoline
-
-
2-(3-chlorophenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(3-fluorophenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(3-methoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(3-nitrophenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(4-bromophenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(4-fluorophenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(4-hydroxyphenyl)-6-nitro-4-phenylquinoline
-
-
2-(4-iodophenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(4-methoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(4-methylphenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(4-methylphenyl)-6-nitro-4-phenylquinoline
-
-
2-(4-nitrophenyl)-4H-naphtho[1,2-b]pyran-4-one
-
2-(5,6,7,8)-tetrahydronaphthyl-N-hexyl carbamate
-
biphasic inhibition time-course
2-(diethylamino)-4H-(1)benzothieno(2,3-d)(1,3)oxazin-4-one
-
-
2-(diethylamino)-4H-3,1-benzoxazin-4-one
-
substrate inhibitor
2-(diethylamino)-4H-thieno[2,3-d][1,3]oxazin-4-one
-
substrate inhibitor
2-(diethylamino)-4H-thieno[2,3-d][1,3]thiazin-4-one
-
substrate inhibitor
2-(diethylamino)-5,6,7,8-tetrahydro-4H-[1]benzothieno[2,3-d][1,3]oxazin-4-one
-
substrate inhibitor
2-(diethylamino)-5,6-dimethyl-4H-thieno(2,3-d)(1,3)oxazin-4-one
-
-
2-(diethylamino)-5-isopropyl-4H-thieno(2,3-d)(1,3)oxazin-4-one
-
-
2-(diethylamino)-5-methyl-5,6,7,8-tetrahydro-4H-(1)benzothieno(2,3-d)(1,3)oxazin-4-one
-
-
2-(diethylamino)-6,7,8,9-tetrahydro-4H,5H-cyclohepta(4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
-
2-(diethylamino)-6,7-dihydro-4H,5H-cyclopenta(4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
i.e. DO-3, significant inhibition of cleavage of cholesteryl esters in high density lipoproteins
2-(diethylamino)-6,7-dihydro-4H,5H-cyclopenta[4,5]thieno[2,3-d][1,3]oxazin-4-one
-
substrate inhibitor
2-(diethylamino)-6,7-dihydro-4H,5H-cyclopenta[4,5]thieno[2,3-d][1,3]thiazin-4-one
-
substrate inhibitor
2-(dimethylamino)-1,2,5,6,7,8-hexahydro-4H-(1)benzothieno(2,3-d)(1,3)oxazin-4-one
-
-
2-(dimethylamino)-1,5,6,7-tetrahydro-2H,4H-cyclopenta(4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
-
2-(dimethylamino)-1,5,6,8-tetrahydro-2H,4H-thiopyrano(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
-
2-(dimethylamino)-5,6,7,8-tetrahydro-4H-[1]benzothieno[2,3-d][1,3]oxazin-4-one
2-(dimethylamino)-6,7-dihydro-4H,5H-cyclopenta[4,5]thieno[2,3-d][1,3]oxazin-4-one
2-morpholin-4-yl-5,6,7,8-tetrahydro-4H-1-benzothieno(2,3-d)(1,3)oxazin-4-one
-
-
2-naphthyl-N-butyl carbamate
2-phenyl-4H-naphtho[1,2-b]pyran-4-one
-
2-[2-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one
-
2-[2-fluoro-4-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one
-
2-[2-fluoro-6-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one
-
2-[3,4-bis[(diethoxyphosphinyl)oxy]phenyl]-4-oxo-4H-1-benzopyran-3,5,7-triyl phosphoric acid hexaethyl ester
-
-
2-[3,4-bis[(diethoxyphosphinyl)oxy]phenyl]-5-hydroxy-4-oxo-4H-1-benzopyran-3,7-diyl phosphoric acid tetraethyl ester
-
-
2-[3,4-bis[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-5,7-diyl tetraethyl bis(phosphate)
-
-
2-[3,5-bis(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one
-
2-[3-(chloromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one
-
2-[3-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one
-
2-[3-fluoro-5-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one
-
2-[3-[(diethoxyphosphinyl)oxy]-4-methoxy-phenyl]-4-oxo-4H-1-benzopyran-5,7-diyl phosphoric acid tetraethyl ester
-
-
2-[4-(chloromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one
-
2-[4-(dimethylamino)phenyl]-4H-naphtho[1,2-b]pyran-4-one
-
2-[4-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one
-
2-[4-fluoro-2-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one
-
2-[4-fluoro-3-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one
-
2-[4-[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-5,7-diyl tetraethyl bis(phosphate)
-
-
2-[5-fluoro-2-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one
-
2-[7-chloro-1-ethoxy-3-(4-ethylphenyl)-1-oxido-1H-2,1-benzoxaphosphinin-4-yl]-1-phenylethanone
-
-
2-[[4-(diethoxyphosphinyl)oxy]phenyl]-5-hydroxy-4-oxo-4H-1-benzopyran-7-yl phosphoric acid diethyl ester
-
-
3,3'-[4-([2-[(4-chlorophenyl)carbonyl]hydrazinyl]sulfonyl)-1,2-oxazole-3,5-diyl]bis(N-hydroxypropanamide)
-
-
3-(2,3-dichlorophenyl)-1H-benzo[f]chromen-1-one
-
3-(2,4-difluorophenyl)-1H-benzo[f]chromen-1-one
-
3-(2,4-dimethoxyphenyl)-1H-benzo[f]chromen-1-one
-
3-(2,5-difluorophenyl)-1H-benzo[f]chromen-1-one
-
3-(2,6-difluorophenyl)-1H-benzo[f]chromen-1-one
-
3-(2-(trifluoromethyl)phenyl)-1H-benzo[f]chromen-1-one
-
3-(2-bromoethoxy)-4-chloro-7-nitro-1H-isochromen-1-one
-
-
3-(2-bromoethoxy)-7-nitro-1H-isochromen-1-one
-
-
3-(2-bromophenyl)-1H-benzo[f]chromen-1-one
-
3-(2-cyclohexylethoxy)-4-trifluoroacetylisocoumarin
-
-
3-(2-cyclohexylethoxy)-7-nitroisocoumarin
-
-
3-(2-fluoro-4-(trifluoromethyl)phenyl)-1H-benzo[f]chromen-1-one
-
3-(2-fluoro-6-(trifluoromethyl)phenyl)-1H-benzo[f]chromen-1-one
-
3-(2-fluorophenyl)-1H-benzo[f]chromen-1-one
-
3-(2-iodophenyl)-1H-benzo[f]chromen-1-one
-
3-(3,4-difluorophenyl)-1H-benzo[f]chromen-1-one
-
3-(3,4-dimethoxyphenyl)-1H-benzo[f]chromen-1-one
-
3-(3,5-bis(trifluoromethyl)phenyl)-1H-benzo[f]chromen-1-one
-
3-(3,5-difluorophenyl)-1H-benzo[f]chromen-1-one
-
3-(3,5-dinitrophenyl)-1H-benzo[f]chromen-1-one
-
3-(3-(acetoxy)phenyl)-1H-benzo[f]chromen-1-one
-
3-(3-(chloromethyl)phenyl)-1H-benzo[f]chromen-1-one
-
3-(3-(trifluoromethyl)phenyl)-1H-benzo[f]chromen-1-one
-
3-(3-bromophenyl)-1H-benzo[f]chromen-1-one
-
3-(3-bromopropoxy)-4-chloro-7-nitro-1H-isochromen-1-one
-
-
3-(3-bromopropoxy)-7-nitro-1H-isochromen-1-one
-
-
3-(3-chlorophenyl)-1H-benzo[f]chromen-1-one
-
3-(3-fluoro-5-(trifluoromethyl)phenyl)-1H-benzo[f]chromen-1-one
-
3-(3-fluorophenyl)-1H-benzo[f]chromen-1-one
-
3-(3-nitrophenyl)-1H-benzo[f]chromen-1-one
-
3-(3-trifluoromethoxyphenyl)-1H-benzo[f]chromen-1-one
-
3-(4-(acetoxy)phenyl)-1H-benzo[f]chromen-1-one
-
3-(4-(chloromethyl)phenyl)-1H-benzo[f]chromen-1-one
-
3-(4-(dimethylamino)phenyl)-1H-benzo[f]chromen-1-one
-
3-(4-(trifluoromethyl)phenyl)-1H-benzo[f]chromen-1-one
-
3-(4-bromophenyl)-1H-benzo[f]chromen-1-one
-
3-(4-fluoro-2-(trifluoromethyl)phenyl)-1H-benzo[f]chromen-1-one
-
3-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-benzo[f]chromen-1-one
-
3-(4-fluorophenyl)-1H-benzo[f]chromen-1-one
-
3-(4-iodophenyl)-1H-benzo[f]chromen-1-one
-
3-(4-methoxyphenyl)-1H-benzo[f]chromen-1-one
-
3-(4-nitrophenyl)-1H-benzo[f]chromen-1-one
-
3-(4-oxo-4H-naphtho[1,2-b]pyran-2-yl)phenyl acetate
-
3-(4-trifluoromethoxyphenyl)-1H-benzo[f]chromen-1-one
-
3-(5-fluoro-2-(trifluoromethyl)phenyl)-1H-benzo[f]chromen-1-one
-
3-benzyl-6-chloro-2-pyrone
-
less selective, potent inhibitor
3-butoxy-4-chloroisocoumarin
-
-
3-butyl-1H-2,1-benzoxaphosphinin-1-ol 1-oxide
-
-
3-butyl-7-chloro-1-ethoxy-1H-2,1-benzoxaphosphinine 1-oxide
-
-
3-cyclohexylmethoxy-7-nitroisocoumarin
-
-
3-cyclohexylmethyl-4-(trifluoroacetyl)isocoumarin
-
-
3-p-tolyl-1H-benzo[f]chromen-1-one
-
3-phenyl-1H-2,1-benzoxaphosphinin-1-ol 1-oxide
-
-
3-phenyl-1H-benzo[f]chromen-1-one
-
3-propoxy-4-(trifluoroacetyl)isocoumarin
-
-
3-[[4-(diethoxyphosphinyl)oxy]phenyl]-4-oxo-4H-1-benzopyran-5,7-diyl phosphoric acid tetraethyl ester
-
-
3-[[4-(diethoxyphosphinyl)oxy]phenyl]-4-oxo-4H-1-benzopyran-7-yl phosphoric acid diethyl ester
-
-
3-[[4-(diethoxyphosphinyl)oxy]phenyl]-5-hydroxy-4-oxo-4H-1-benzopyran-7-yl phosphoric acid diethyl ester
-
-
4,7-dichloro-1-ethoxy-3-(4-ethylphenyl)-1H-2,1-benzoxaphosphinine 1-oxide
-
-
4,7-dichloro-1-ethoxy-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
-
-
4,7-dichloro-3-cyclopropyl-1-ethoxy-1H-2,1-benzoxaphosphinine 1-oxide
-
-
4,7-dichloro-3-phenyl-1H-2,1-benzoxaphosphinin-1-ol 1-oxide
-
-
4-(4-oxo-4H-naphtho[1,2-b]pyran-2-yl)phenyl acetate
-
4-bromo-1-ethoxy-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
-
-
4-bromo-1-ethoxy-7-methoxy-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
-
-
4-bromo-3-phenyl-1H-2,1-benzoxaphosphinin-1-ol 1-oxide
-
-
4-bromo-7-chloro-1-ethoxy-3-(4-ethylphenyl)-1H-2,1-benzoxaphosphinine 1-oxide
-
-
4-bromo-7-chloro-1-ethoxy-3-(4-methoxyphenyl)-1H-2,1-benzoxaphosphinine 1-oxide
-
-
4-bromo-7-chloro-1-ethoxy-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
-
-
4-bromo-7-methoxy-3-phenyl-1H-2,1-benzoxaphosphinin-1-ol 1-oxide
-
-
4-chloro-1-ethoxy-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
-
-
4-chloro-1-ethoxy-7-methoxy-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
-
-
4-chloro-3-(2-cyclohexylethoxy)-7-nitroisocoumarin
-
-
4-chloro-3-(2-cyclohexylethoxy)isocoumarin
-
-
4-chloro-3-(2-cyclopentylethoxy)isocoumarin
-
-
4-chloro-3-(3-cyclohexylpropoxy)isocoumarin
-
-
4-chloro-3-(3-cyclopentylpropoxy)-1H-isochromen-1-one
-
-
4-chloro-3-(3-cyclopentylpropoxy)isocoumarin
-
potent reversible inhibitor
4-chloro-3-(4-cyclohexylbutoxy)-1H-isochromen-1-one
-
-
4-chloro-3-(4-cyclohexylbutoxy)isocoumarin
-
potent reversible inhibitor
4-chloro-3-(4-cyclohexylcyclohexyloxy)isocoumarin
-
-
4-chloro-3-(5-cyclohexylpentoxy)isocoumarin
-
-
4-chloro-3-(cyclohexylmethoxy)isocoumarin
-
-
4-chloro-3-(cyclopentylmethoxy)isocoumarin
-
-
4-chloro-3-(cyclopentyloxy)isocoumarin
-
-
4-chloro-3-cyclohexylmethoxy-7-nitroisocoumarin
-
-
4-chloro-3-cyclopropyl-1-ethoxy-7-methoxy-1H-2,1-benzoxaphosphinine 1-oxide
-
-
4-chloro-3-methoxy-7-nitroisocoumarin
-
-
4-chloro-3-phenyl-1H-2,1-benzoxaphosphinin-1-ol 1-oxide
-
-
4-chloro-3-propoxyisocoumarin
-
-
4-chloro-7-cyclohexanecarboxamide-3-methoxyisocoumarin
-
-
4-nitrophenyl-N-allyl carbamate
-
mechanism of inhibition by these pseudo-substrate inhibitors, via a 2-step reaction including the formation of a tetrahedral enzyme-inhibitor adduct and the formation of the carbamyl-enzyme, inhibition kinetics
4-nitrophenyl-N-butyl carbamate
-
mechanism of inhibition by these pseudo-substrate inhibitors, via a 2-step reaction including the formation of a tetrahedral enzyme-inhibitor adduct and the formation of the carbamyl-enzyme, inhibition kinetics
4-nitrophenyl-N-chloroethyl carbamate
-
mechanism of inhibition by these pseudo-substrate inhibitors, via a 2-step reaction including the formation of a tetrahedral enzyme-inhibitor adduct and the formation of the carbamyl-enzyme, inhibition kinetics
4-nitrophenyl-N-hexyl carbamate
-
mechanism of inhibition by these pseudo-substrate inhibitors, via a 2-step reaction including the formation of a tetrahedral enzyme-inhibitor adduct and the formation of the carbamyl-enzyme, inhibition kinetics
4-nitrophenyl-N-methylphenyl carbamate
-
mechanism of inhibition by these pseudo-substrate inhibitors, via a 2-step reaction including the formation of a tetrahedral enzyme-inhibitor adduct and the formation of the carbamyl-enzyme, inhibition kinetics
4-nitrophenyl-N-octyl carbamate
-
mechanism of inhibition by these pseudo-substrate inhibitors, via a 2-step reaction including the formation of a tetrahedral enzyme-inhibitor adduct and the formation of the carbamyl-enzyme, inhibition kinetics
4-oxo-2-phenyl-4H-1-benzopyran-5,6,7-triyl phosphoric acid hexaethyl ester
-
-
4-oxo-2-phenyl-4H-1-benzopyran-7-yl phosphoric acid dimethyl ester
-
-
4-[3,5-bis(trifluoromethyl)phenyl]-N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]piperazine-1-carboxamide
5,5-dithiobis(2-nitrobenzoic acid)
-
80% inhibition at 10 mM
5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one
-
-
5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
-
-
5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
-
-
5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-6,7-diyl phosphoric acid tetraethyl ester
-
-
5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl phosphoric acid diethyl ester
-
-
5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl phosphoric acid dimethyl ester
-
-
5-[3,5-bis[3-(1H-imidazol-5-yl)propyl]-1,2-oxazol-4-yl]-3-[[(4-chlorophenyl)sulfonyl]methyl]-1,2,4-oxadiazole
-
-
6-chloro-2,4-diphenylquinoline
-
-
6-chloro-2-(1H-indol-3-yl)-4-phenylquinoline
-
-
6-chloro-2-(4-hydroxyphenyl)-4-phenylquinoline
-
-
6-chloro-2-(4-methoxyphenyl)-4-phenylquinoline
-
-
6-chloro-2-(4-methylphenyl)-4-phenylquinoline
-
-
6-chloro-3-(1-ethyl-2-cyclohexyl)-2-pyrone
-
selective, potent, and reversible inhibitor, not toxic in vivo, enzyme inhibition effectively reduces cholesterol uptake in vivo
6-chloro-3-(2-cyclohexylethyl)-2H-pyran-2-one
6-chloro-3-(2-cyclopentylethyl)-2H-pyran-2-one
6-chloro-3-(2-cyclopentylethyl)-5-methyl-2H-pyran-2-one
6-chloro-3-(2-phenylethyl)-2H-pyran-2-one
6-chloro-3-(3-cyclohexylpropyl)-2H-pyran-2-one
6-chloro-3-(4-cyclohexylbutyl)-2H-pyran-2-one
6-chloro-3-(cyclohexylmethyl)-2H-pyran-2-one
6-chloro-3-cyclohexyl-2H-pyran-2-one
6-chloro-3-cyclopentyl-2H-pyran-2-one
6-chloro-5-(2-cyclohexylethyl)-3-methyl-2H-pyran-2-one
6-chloro-5-methyl-3-(2-phenylethyl)-2H-pyran-2-one
6-nitro-2,4-diphenylquinoline
-
-
7-amino-3-(2-bromoethoxy)-4-chloro-1H-isochromen-1-one
-
-
7-amino-3-(2-bromoethoxy)isocoumarin
-
-
7-amino-4-chloro-3-methoxyisocoumarin
-
-
7-benzamido-4-chloro-3-methoxyisocoumarin
-
-
7-chloro-1-ethoxy-3-(4-ethylphenyl)-1H-2,1-benzoxaphosphinine 1-oxide
-
-
7-chloro-1-ethoxy-3-(4-ethylphenyl)-4-(phenylethynyl)-1H-2,1-benzoxaphosphinine 1-oxide
-
-
7-chloro-1-ethoxy-3-(4-ethylphenyl)-4-iodo-1H-2,1-benzoxaphosphinine 1-oxide
-
-
7-chloro-1-ethoxy-3-(4-nitrophenyl)-1H-2,1-benzoxaphosphinine 1-oxide
-
-
7-chloro-1-ethoxy-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
-
-
7-chloro-1-ethoxy-4-iodo-3-(4-methoxyphenyl)-1H-2,1-benzoxaphosphinine 1-oxide
-
-
7-chloro-1-ethoxy-4-iodo-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
-
-
7-chloro-3-(4-ethylphenyl)-1H-2,1-benzoxaphosphinin-1-ol 1-oxide
-
-
7-chloro-3-phenyl-1H-2,1-benzoxaphosphinin-1-ol 1-oxide
-
-
7-methoxy-3-phenyl-1H-2,1-benzoxaphosphinin-1-ol 1-oxide
-
-
albumin
-
50% inhibition by addition of 0.015-0.045 mg, increasing inhibition after heat treatment of albumin
-
Alkaline phosphatase
-
65% inhibition
-
amlodipine
-
mixed-type, study on kinetics in presence of Triton X-100 or taurocholate
aryl-N-alkyl carbamates
-
AS115
nonspecific inhibitor, the enzyme is about 85% inhibited by 0.01 mM AS115
benzene-1,2-di-N-benzylcarbamate
-
pseudo substrate inhibitor
benzene-1,2-di-N-n-butylcarbamate
-
pseudo substrate inhibitor
benzene-1,2-di-N-n-hexylcarbamate
-
pseudo substrate inhibitor
benzene-1,2-di-N-n-octylcarbamate
-
pseudo substrate inhibitor
benzene-1,2-di-N-t-butylcarbamate
-
pseudo substrate inhibitor
benzene-1,3-di-N-benzylcarbamate
-
pseudo substrate inhibitor
benzene-1,3-di-N-n-butylcarbamate
-
pseudo substrate inhibitor
benzene-1,3-di-N-n-hexylcarbamate
-
pseudo substrate inhibitor
benzene-1,3-di-N-n-octylcarbamate
-
pseudo substrate inhibitor
benzene-1,3-di-N-t-butylcarbamate
-
pseudo substrate inhibitor
benzene-1,4-di-N-benzylcarbamate
-
pseudo substrate inhibitor
benzene-1,4-di-N-n-butylcarbamate
-
pseudo substrate inhibitor
benzene-1,4-di-N-n-hexylcarbamate
-
pseudo substrate inhibitor
benzene-1,4-di-N-octylcarbamates
-
pseudo substrate inhibitor
benzene-1,4-di-N-t-butylcarbamate
-
pseudo substrate inhibitor
besylate
-
mixed-type, study on kinetics in presence of Triton X-100 or taurocholate
bisphenol A dimethacrylate
-
computational study on inhibitory effect. Bisphenol A dimethacrylate mimics chemical properties of reported enzyme inhibitors, particularly concerning maximum oxygen valency and molecular shape/size
bisphenol A methacrylate
-
competitive inhibition
brefeldin A
-
inhibition to 80%-90% of secreted enzyme into the medium of HepG2 cells
cardiolipin
-
inhibitory if included as aqueous sonicated dispersions at 2.5 mg/ml
Cd2+
-
very potent inhibitor
Chloropromazine
-
50% inhibition at 0.05 mM
cholate
-
activity decreases gradually from 5 to 40 mM cholate
cholesterol
-
80-100% inhibition at 0.01-0.15 mM
cholesteryl esters
-
inhibition at 0.2 mM with cholesteryl-stearate, -oleate, -eicosenoate, -arachidonate, -erucate and -nervonate
cytosolic protein factor
-
deoxycholate
-
0.1% v/v, hydrolysis not detectable
diethyl 4-oxo-2-phenyl-4H-chromen-6-yl phosphate
-
-
diethyl 4-oxo-2-phenyl-4H-chromen-7-yl phosphate
-
-
diethyl phosphate
-
70% ihibition at 0.3 mM
diethyldicarbonate
-
complete inactivation at 2 mM
diisopropylfluorophosphate
dimethyl 5-hydroxy-4-oxo-2-phenyl-4H-chromen-4',7-yl phosphate
-
-
dodecylboronic acid
-
50% inhibition at 1 mM
E600
-
strong for neutral cholesterol esterases
Fe3+
-
56% inhibition at 10 mM
heparin
-
50% inhibition for CEase-ISF II at 0.025 mM, no inhibition for CEase-IF I
hydralazine hydrochloride
-
mixed-type, study on kinetics in presence of Triton X-100 or taurocholate
iodoacetamide
-
modest inactivation
lovastatin
-
mixed-type, study on kinetics in presence of Triton X-100 or taurocholate
methyl 3-[(2-ethoxy-2-oxoethyl)(methyl)sulfamoyl]-5-[2-(1H-pyrrol-2-yl)ethyl]thiophene-2-carboxylate
-
-
MgSO4
-
abolishes activity at 0.15 M
monensin
-
inhibition to 50%-60% of secreted enzyme into the medium of HepG2 cells
N,N,N',N'-tetra(prop-2-en-1-yl)propane-1,3-disulfonamide
-
-
N-(3,5-dichlorophenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
N-(3,5-difluorophenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
N-(3,5-dimethoxyphenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
N-(3,5-dimethylphenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
N-(3,5-dinitrophenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
N-(4-bromophenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
N-(4-chlorophenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
N-[3',5'-bis(trifluoromethyl)[1,1'-biphenyl]-2-yl]-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
N-[3',5'-bis(trifluoromethyl)[1,1'-biphenyl]-3-yl]-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
N-[3',5'-bis(trifluoromethyl)[1,1'-biphenyl]-4-yl]-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
N-[3,5-bis(trifluoromethyl)phenyl]-5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)pentanamide
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]urea
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[3-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)propyl]urea
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[3-[(3aR,4S,7R,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]propyl]urea
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[3-[(3aR,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl]propyl]urea
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[3-[(3aR,7aS)-1,3-dioxooctahydro-2H-isoindol-2-yl]propyl]urea
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]urea
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)pentyl]urea
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-4-phenylpiperazine-1-carboxamide
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-N'-(4-fluorophenyl)urea
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-N'-(4-methoxyphenyl)urea
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-N'-(4-methylphenyl)urea
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-N'-(4-nitrophenyl)urea
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-N'-phenylurea
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-N'-[4-(trifluoromethyl)phenyl]urea
Na+
-
93% residual activity at mM
NaN3
-
93.6% residual activity at 1 mM
nifedipine
-
mixed-type, study on kinetics in presence of Triton X-100 or taurocholate
O-butyl phenylcarbamothioate
-
-
oleate
-
25-40% inhibition at 0.002-0.003 mM
p-bromophenacylbromide
-
strong inhibition at 0.2 mM
p-chloromercuribenzoic acid
p-chloromercuriphenyl sulfonic acid
-
0.2 mM strongly inhibitory
p-nitrophenyl-N-dodecyl-carbamate
-
80%-85% inhibition at 0.002-0.005 mM
p-nitrophenyl-N-octyl-carbamate
-
80%-85% inhibition at 0.002-0.005 mM
paraoxon
selective inhibitor
phenyl-n-butylboronic acid
-
tight-binding competetive inhibitor
phenylboronic acid
-
50% inhibition at 10 mM
Phenylmethylsulfonylfluoride
phosphatidic acid
-
slight inhibition
phosphatidylcholine
-
slightly inhibitory at higher concentrations
phosphatidylethanolamine
-
-
phosphatidylinositol
-
inhibitory if included as aqueous sonicated dispersions at 2.5 mg/ml
simvastatin
-
mixed-type, study on kinetics in presence of Triton X-100 or taurocholate
sodium cholate
-
50% inhibition at 0.05-0.1% v/v
sodium deoxycholate
-
complete inhibition
Sodium dodecyl sulfate
-
complete inactivation
testosterone
-
19% inhibition at 0.035 mM
tetraethyl 4-oxo-2-phenyl-4H-chromene-5,7-diyl bis(phosphate)
-
-
Tween 60
-
48% inhibition at 1%
wine polyphenolic extract
-
Zn2+
-
at very low concentrations
2-(dimethylamino)-5,6,7,8-tetrahydro-4H-[1]benzothieno[2,3-d][1,3]oxazin-4-one
noncompetitive inhibition
2-(dimethylamino)-5,6,7,8-tetrahydro-4H-[1]benzothieno[2,3-d][1,3]oxazin-4-one
-
2-(dimethylamino)-6,7-dihydro-4H,5H-cyclopenta[4,5]thieno[2,3-d][1,3]oxazin-4-one
noncompetitive inhibition
2-(dimethylamino)-6,7-dihydro-4H,5H-cyclopenta[4,5]thieno[2,3-d][1,3]oxazin-4-one
-
2-mercaptoethanol
1 mM, 77% residual activity
2-mercaptoethanol
-
1 mM, 94% residual activity
2-naphthyl-N-butyl carbamate
-
biphasic time course, reversible non-covalent enzyme-carbamate complex
2-naphthyl-N-butyl carbamate
-
inhibition by 80% at 0.125 mM
4-[3,5-bis(trifluoromethyl)phenyl]-N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]piperazine-1-carboxamide
65.2% activity compared to control, at 0.025 mM
4-[3,5-bis(trifluoromethyl)phenyl]-N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]piperazine-1-carboxamide
95.3% activity compared to control, at 0.025 mM
6-chloro-3-(2-cyclohexylethyl)-2H-pyran-2-one
-
-
6-chloro-3-(2-cyclohexylethyl)-2H-pyran-2-one
-
competitive
6-chloro-3-(2-cyclohexylethyl)-2H-pyran-2-one
-
-
6-chloro-3-(2-cyclopentylethyl)-2H-pyran-2-one
-
competitive
6-chloro-3-(2-cyclopentylethyl)-2H-pyran-2-one
-
-
6-chloro-3-(2-cyclopentylethyl)-5-methyl-2H-pyran-2-one
-
competitive
6-chloro-3-(2-cyclopentylethyl)-5-methyl-2H-pyran-2-one
-
-
6-chloro-3-(2-phenylethyl)-2H-pyran-2-one
-
competitive
6-chloro-3-(2-phenylethyl)-2H-pyran-2-one
-
-
6-chloro-3-(3-cyclohexylpropyl)-2H-pyran-2-one
-
competitive
6-chloro-3-(3-cyclohexylpropyl)-2H-pyran-2-one
-
-
6-chloro-3-(4-cyclohexylbutyl)-2H-pyran-2-one
-
competitive
6-chloro-3-(4-cyclohexylbutyl)-2H-pyran-2-one
-
-
6-chloro-3-(cyclohexylmethyl)-2H-pyran-2-one
-
competitive
6-chloro-3-(cyclohexylmethyl)-2H-pyran-2-one
-
-
6-chloro-3-cyclohexyl-2H-pyran-2-one
-
competitive
6-chloro-3-cyclohexyl-2H-pyran-2-one
-
-
6-chloro-3-cyclopentyl-2H-pyran-2-one
-
-
6-chloro-3-cyclopentyl-2H-pyran-2-one
-
competitive
6-chloro-3-cyclopentyl-2H-pyran-2-one
-
-
6-chloro-5-(2-cyclohexylethyl)-3-methyl-2H-pyran-2-one
-
competitive
6-chloro-5-(2-cyclohexylethyl)-3-methyl-2H-pyran-2-one
-
-
6-chloro-5-methyl-3-(2-phenylethyl)-2H-pyran-2-one
-
competitive
6-chloro-5-methyl-3-(2-phenylethyl)-2H-pyran-2-one
-
-
Ag+
-
23.4% residual activity at 1 mM
Ag+
1 mM, 72% residual activity
Ag+
1 mM, 81% residual activity
Ag+
-
1 mM, 80% residual activity
Ag+
-
1 mM, 75% residual activity
Ag+
1 mM, 75% residual activity
ammonium chloride
-
slightly inhibitory
ammonium chloride
-
25% inhibition
ammonium chloride
-
slightly inhibitory
aryl-N-alkyl carbamates
-
-
-
aryl-N-alkyl carbamates
-
-
-
Ca2+
-
50% inhibition at 5 mM
Ca2+
-
complete inactivation at 10 mM
Ca2+
-
18% inhibition at 1 mM
Chloroquine
-
90% inhibition at 30 mM
Chloroquine
-
90% inhibition at 30 mM
cholic acid
-
0.3%, 50% residual activity
cholic acid
0.3%, 85% residual activity
Cu2+
1 mM, 61% residual activity
Cu2+
-
strong inhibition at 2 mM
Cu2+
-
at very low concentrations
cytosolic protein factor
-
unknown protein in macrophages
-
cytosolic protein factor
-
sexual differences in level of inhibitory activity, pregnancy and lactation lead to decreased activity of the inhibitory protein, level of inhibitory protein responses to hormonal and nutritional status of females
-
deoxycholic acid
0.3%, 40% residual activity
deoxycholic acid
-
0.3%, 25% residual activity
deoxycholic acid
-
1 mM, 60% inhibition
deoxycholic acid
0.3%, 33% residual activity
diisopropylfluorophosphate
-
50% inhibition at 0.005 mM
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
modifies a serine residue at the active site
diisopropylfluorophosphate
-
30% inhibition at 0.2 mM
diisopropylfluorophosphate
-
complete inhibition above 0.1 mM
dithiothreitol
-
65.3% residual activity at 1 mM
dithiothreitol
-
for neutral cholesterol esterase with pH optimum at 6.0 and for acid cholesterol esterase
dithiothreitol
1 mM, complete loss of activity
dithiothreitol
-
1 mM, complete loss of activity
dithiothreitol
-
1 mM, 0% residual activity
dithiothreitol
1 mM, complete loss of activity
EDTA
-
inhibition only for neutral cholesterol esterases
EDTA
-
20% inhibition at 10 mM
enolase
-
inhibitory effect by binding cholesteryl oleate to enolase
-
enolase
-
inhibitory effect by binding cholesteryl oleate to enolase; more insensitive against inhibition, competitive inhibition
-
enolase
-
inhibitory effect by binding cholesteryl oleate to enolase; non-competitive inhibition, activity in liver microsomes more sensitive to inhibition
-
Hg2+
-
22.9% residual activity at 1 mM
Hg2+
-
50% inhibition at 0.01 mM
Hg2+
1 mM, 11% residual activity
Hg2+
-
strong for acid and less for neutral cholesterol esterases
Hg2+
-
54% inhibition at 10 mM
Hg2+
1 mM, complete loss of activity
Hg2+
-
1 mM, 40% residual activity
Hg2+
-
1 mM, 50% residual activity
Hg2+
1 mM, 50% residual activity
iodoacetate
-
acid and neutral cholesterol esterases
iodoacetate
-
100% inhibition at 50 mM
KCl
-
25% inhibition at 0.15 M
KCl
1 mM, 90% residual activity
Mg2+
-
44% inhibition at 5 mM
Mg2+
-
11% inhibition at 1 mM
N-(3,5-dichlorophenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
104% activity compared to control, at 0.025 mM
N-(3,5-dichlorophenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
100% activity compared to control, at 0.025 mM
N-(3,5-difluorophenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
103% activity compared to control, at 0.025 mM
N-(3,5-difluorophenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
88.4% activity compared to control, at 0.025 mM
N-(3,5-dimethoxyphenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
110% activity compared to control, at 0.025 mM
N-(3,5-dimethoxyphenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
103% activity compared to control, at 0.025 mM
N-(3,5-dimethylphenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
105% activity compared to control, at 0.025 mM
N-(3,5-dimethylphenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
94.7% activity compared to control, at 0.025 mM
N-(3,5-dinitrophenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
80.5% activity compared to control, at 0.025 mM
N-(3,5-dinitrophenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
85.3% activity compared to control, at 0.025 mM
N-(4-bromophenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
104% activity compared to control, at 0.025 mM
N-(4-bromophenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
94.5% activity compared to control, at 0.025 mM
N-(4-chlorophenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
112% activity compared to control, at 0.025 mM
N-(4-chlorophenyl)-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
64.0% activity compared to control, at 0.025 mM
N-ethylmaleimide
-
for acid and neutral cholesterol esterases
N-ethylmaleimide
-
50% inhibition at 50 mM in 10 min
N-ethylmaleimide
-
modest inactivation
N-ethylmaleimide
-
complete loss of activity
N-ethylmaleimide
-
72% inhibition at 3 mM
N-ethylmaleimide
-
complete loss of activity
N-[3',5'-bis(trifluoromethyl)[1,1'-biphenyl]-2-yl]-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
72.5% activity compared to control, at 0.025 mM
N-[3',5'-bis(trifluoromethyl)[1,1'-biphenyl]-2-yl]-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
87.8% activity compared to control, at 0.025 mM
N-[3',5'-bis(trifluoromethyl)[1,1'-biphenyl]-3-yl]-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
100% activity compared to control, at 0.025 mM
N-[3',5'-bis(trifluoromethyl)[1,1'-biphenyl]-3-yl]-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
73.5% activity compared to control, at 0.025 mM
N-[3',5'-bis(trifluoromethyl)[1,1'-biphenyl]-4-yl]-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
90.2% activity compared to control, at 0.025 mM
N-[3',5'-bis(trifluoromethyl)[1,1'-biphenyl]-4-yl]-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
58.2% activity compared to control, at 0.025 mM
N-[3,5-bis(trifluoromethyl)phenyl]-5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)pentanamide
81.3% activity compared to control, at 0.025 mM; 91.1% activity compared to control, at 0.025 mM
N-[3,5-bis(trifluoromethyl)phenyl]-5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)pentanamide
71.8% activity compared to control, at 0.025 mM; 90.8% activity compared to control, at 0.025 mM
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]urea
97.4% activity compared to control, at 0.025 mM
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]urea
108% activity compared to control, at 0.025 mM
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[3-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)propyl]urea
64.8% activity compared to control, at 0.025 mM
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[3-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)propyl]urea
71.0% activity compared to control, at 0.025 mM
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
noncompetitive inhibition, 64.1% activity compared to control, at 0.025 mM
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
5.25% activity compared to control, at 0.025 mM
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[3-[(3aR,4S,7R,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]propyl]urea
84.8% activity compared to control, at 0.025 mM
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[3-[(3aR,4S,7R,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]propyl]urea
96.6% activity compared to control, at 0.025 mM
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[3-[(3aR,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl]propyl]urea
72.4% activity compared to control, at 0.025 mM
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[3-[(3aR,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl]propyl]urea
82.9% activity compared to control, at 0.025 mM
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[3-[(3aR,7aS)-1,3-dioxooctahydro-2H-isoindol-2-yl]propyl]urea
80.6% activity compared to control, at 0.025 mM
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[3-[(3aR,7aS)-1,3-dioxooctahydro-2H-isoindol-2-yl]propyl]urea
89.1% activity compared to control, at 0.025 mM
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]urea
competitive inhibition, 68.5% activity compared to control, at 0.025 mM
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]urea
15.6% activity compared to control, at 0.025 mM
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)pentyl]urea
49.3% activity compared to control, at 0.025 mM
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)pentyl]urea
22.5% activity compared to control, at 0.025 mM
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-4-phenylpiperazine-1-carboxamide
106% activity compared to control, at 0.025 mM
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-4-phenylpiperazine-1-carboxamide
101% activity compared to control, at 0.025 mM
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-N'-(4-fluorophenyl)urea
107% activity compared to control, at 0.025 mM
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-N'-(4-fluorophenyl)urea
101% activity compared to control, at 0.025 mM
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-N'-(4-methoxyphenyl)urea
107% activity compared to control, at 0.025 mM
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-N'-(4-methoxyphenyl)urea
90.4% activity compared to control, at 0.025 mM
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-N'-(4-methylphenyl)urea
105% activity compared to control, at 0.025 mM
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-N'-(4-methylphenyl)urea
100% activity compared to control, at 0.025 mM
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-N'-(4-nitrophenyl)urea
85.3% activity compared to control, at 0.025 mM
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-N'-(4-nitrophenyl)urea
76.5% activity compared to control, at 0.025 mM
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-N'-phenylurea
108% activity compared to control, at 0.025 mM
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-N'-phenylurea
107% activity compared to control, at 0.025 mM
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-N'-[4-(trifluoromethyl)phenyl]urea
116% activity compared to control, at 0.025 mM
N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-N'-[4-(trifluoromethyl)phenyl]urea
92.5% activity compared to control, at 0.025 mM
NaCl
-
acid and neutral cholesterol esterases
NaCl
-
25% inhibition at 0.15 M
NaCl
-
31% inhibition at 1 mM
NaCl
31% inhibition at 1 mM
NaCl
-
44% inhibition at 0.5 M
NaF
-
50% inhibition at 3 mM
NaF
-
abolishes activity at 0.15 M
NaF
-
65% inhibition at 5 mM
NaF
-
54% inhibition at 1 mM
p-chloromercuribenzoate
-
76% inhibition at 1 mM
p-chloromercuribenzoate
-
84% inhibition at 0.25 mM
p-chloromercuribenzoate
-
1 mM, 78% residual activity
p-chloromercuribenzoic acid
1 mM, 75% residual activity
p-chloromercuribenzoic acid
-
1 mM, 87% residual activity
p-chloromercuribenzoic acid
1 mM, 78% residual activity
p-hydroxymercuribenzoate
-
strongest inactivation for acid cholesterol esterase, modest for neutral cholesterol esterase with pH optimum 6.0
p-hydroxymercuribenzoate
-
50% inhibition at 0.2-0.4 mM
p-mercuribenzoate
-
30% inhibition at 3 mM
p-mercuribenzoate
-
60% inhibition
p-mercuribenzoate
-
15% and 80% inhibition at 1 and 8.3 mM, partially reversed by addition of DTT
Phenylmethylsulfonylfluoride
-
30% inhibition at 0.2 mM
Phenylmethylsulfonylfluoride
-
50% inhibition at 0.1 mM
Phenylmethylsulfonylfluoride
-
marked inhibition after preincubation with taurocholat
phosphatidylserine
-
complete inhibition at 0.05 mM for cholesteryl oleate hydrolysis, for triolein hydrolysis 65% inhibition, p-nitrophenyl butyrate hydrolysis not affected
phosphatidylserine
-
inhibitory if included as aqueous sonicated dispersions at 2.5 mg/ml
progesterone
-
marked inhibition, additive effect if chloroquine is present
progesterone
-
38% inhibition at 0.06 mM
progesterone
-
marked inhibition, additive effect if chloroquine is present
Protamine sulfate
-
18% inhibition at 500 mg/ml
-
Protamine sulfate
-
55% inhibition at 0.36 M
-
resveratrol
-
-
SDS
-
50.3% residual activity at 0.1% (w/v)
SDS
-
33% inhibition at 1%
sodium taurocholic acid
-
marked inhibition above 0.015 mM
sodium taurocholic acid
-
inhibition higher than 2.5 mM for cholesteryl oleate and triolein hydrolysis
taurocholate
-
inhibits CRL1, not CRL3
Triton X-100
-
39% inhibition at 0.1%
Triton X-100
-
0.1% v/v, 12% substrate hydrolyzed in the presence of bile salts
Triton X-100
-
complete inactivation
Triton X-100
-
20% inactivation at 20 mM
Triton X-100
-
inhibition above 0.1% w/v
Tween 20
-
15% inhibition at 1%
Tween 20
0.3%, 25% residual activity
Tween 20
-
0.3%, 50% residual activity
Tween 20
0.3%, 45% residual activity
Tween 40
-
40% inhibition at 1%
Tween 40
-
0.1% v/v, hydrolysis not detectable
Tween 80
-
90.1% residual activity at 1 mM
Tween 80
-
51% inhibition at 1%
Tween 80
-
0.3%, 90% residual activity
Tween 80
0.3%, 30% residual activity
wine polyphenolic extract
-
-
-
wine polyphenolic extract
-
-
-
additional information
-
not inhibited by phenylmethylsulfonyl fluoride, (1 mM)
-
additional information
-
pKi values of cardiovascular drug inhibitors such as lovastatin, simvastatin, amlodipine, besylate, nifedipine, and hydralazine hydrochloride correlate with their molecular weight
-
additional information
benzoflavones as cholesterol esterase inhibitors, synthesis, biological evaluation, and molecular protein-ligand docking studies using the active site structure of the human CEase (PDB ID 1F6W), overview. 7,8-benzoflavone derivatives are synthesized and evaluated for their inhibitory potential against cholesterol esterase
-
additional information
omega-phthalimidoalkyl aryl ureas as potent and selective inhibitors of cholesterol esterase, synthesis and inhibitory potencies. The urea motif with an attached 3,5-bis(trifluoromethyl)phenyl group and the aromatic character of the omega-phthalimide residue are most important for inhibitory activity. In addition, an alkyl chain composed of three or four methylene groups, connecting the urea and phthalimide moieties, is an optimal spacer for inhibitors. Structure-activity relationships depending on the spacer length and urea/amide motif, overview
-
additional information
bitter melon aqueous extracts inhibits pancreatic cholesterol esterase in vitro and reduces cholesterol micellar solubility, decrease of alpha-helix contents, increase of beta-sheet and exposure of aromatic amino acid residuals
-
additional information
5,6-benzoflavones as cholesterol esterase inhibitors, synthesis, biological evaluation, and molecular docking studies. NMR structure analysis of the compounds. In silico absorption, distribution, metabolism, and excretion (ADME) properties of 5,6-benzoflavone derivatives, overview
-
additional information
-
substituted 6-chloro-2-pyrones can be simple reversible inhibitors or irreversible active site inhibitors where an active site nucleophile attacks the 6-postion of the pyrone with release of chloride
-
additional information
not inhibited by orlistat and benzil
-
additional information
-
not inhibited by orlistat and benzil
-
additional information
omega-phthalimidoalkyl aryl ureas as potent and selective inhibitors of cholesterol esterase, synthesis and inhibitory potencies. The urea motif with an attached 3,5-bis(trifluoromethyl)phenyl group and the aromatic character of the omega-phthalimide residue are most important for inhibitory activity. In addition, an alkyl chain composed of three or four methylene groups, connecting the urea and phthalimide moieties, is an optimal spacer for inhibitors, Structure-activity relationships depending on the spacer length and urea/amide motif, overview
-
additional information
-
no inhibition by Na+, Ag+, NH4+, Mg2+, Ca2+, Zn2+, Pb2+, NaN3, KCN, 2-mercaptoethanol, and PMSF
-
additional information
-
no inhibition by iodoacetic acid, DTNB, EDTA and tetranitromethane
-
additional information
-
inactivation of the hormone-sensitive lipase HSL by homologous recombination leads to 98% reduction of cholesteryl esterase activity
-
additional information
-
not inhibitory: phenylmethylsulfonylfluoride
-
additional information
-
not inhibited by 2-(4-methoxyphenyl)-6-nitro-4-phenylquinoline
-
additional information
-
not inhibited by 4-oxo-2-phenyl-4H-1-benzopyran-6-yl phosphoric acid dimethyl ester
-
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0.0002
(1R, alphaR)-2'-N-alpha-methylbenzylcarbamyl-1,1'-bi-2-naphthol
-
pH 7.0, 25°C
0.0005
(1R, alphaS)-2'-N-alpha-methylbenzylcarbamyl-1,1'-bi-2-naphthol
-
pH 7.0, 25°C
0.002
(1S, alphaR)-2'-N-alpha-methylbenzylcarbamyl-1,1'-bi-2-naphthol
-
pH 7.0, 25°C
0.006
(1S, alphaS)-2'-N-alpha-methylbenzylcarbamyl-1,1'-bi-2-naphthol
-
pH 7.0, 25°C
0.0008
(R)-2'-N-butylcarbamyl-1,1'-bi-naphthol
-
pH 7.0, 25°C
0.009
(R)-endo-2-norbornyl-N-n-butyl-carbamate
-
in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C
0.0004
(R)-exo-2-norbornyl-N-n-butylcarbamate
-
in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C
0.0013
(S)-2'-N-butylcarbamyl-1,1'-bi-naphthol
-
pH 7.0, 25°C
0.0013
(S)-endo-2-norbornyl-N-n-butyl-carbamate
-
in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C
0.0025
(S)-exo-2-norbornyl-N-n-butylcarbamate
-
in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C
0.0075
2-(diethylamino)-4H-(1)benzothieno(2,3-d)(1,3)oxazin-4-one
-
pH 7.0
0.053
2-(diethylamino)-4H-3,1-benzoxazin-4-one
-
pH 7.0, 25°C
0.0019
2-(diethylamino)-5,6,7,8-tetrahydro-4H-[1]benzothieno[2,3-d][1,3]oxazin-4-one
-
pH 7.0, 25°C
0.0043
2-(diethylamino)-5,6-dimethyl-4H-thieno(2,3-d)(1,3)oxazin-4-one
-
pH 7.0
0.0064
2-(diethylamino)-5-isopropyl-4H-thieno(2,3-d)(1,3)oxazin-4-one
-
pH 7.0
0.00164
2-(diethylamino)-5-methyl-5,6,7,8-tetrahydro-4H-(1)benzothieno(2,3-d)(1,3)oxazin-4-one
-
pH 7.0
0.006
2-(diethylamino)-6,7,8,9-tetrahydro-4H,5H-cyclohepta(4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
pH 7.0
0.00058
2-(diethylamino)-6,7-dihydro-4H,5H-cyclopenta[4,5]thieno[2,3-d][1,3]oxazin-4-one
-
pH 7.0, 25°C
0.00215
2-(dimethylamino)-1,2,5,6,7,8-hexahydro-4H-(1)benzothieno(2,3-d)(1,3)oxazin-4-one
-
pH 7.0
0.00063
2-(dimethylamino)-1,5,6,7-tetrahydro-2H,4H-cyclopenta(4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
pH 7.0
0.00576
2-(dimethylamino)-1,5,6,8-tetrahydro-2H,4H-thiopyrano(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
pH 7.0
0.000262 - 0.00431
2-(dimethylamino)-5,6,7,8-tetrahydro-4H-[1]benzothieno[2,3-d][1,3]oxazin-4-one
0.0000341 - 0.00434
2-(dimethylamino)-6,7-dihydro-4H,5H-cyclopenta[4,5]thieno[2,3-d][1,3]oxazin-4-one
0.0057
2-morpholin-4-yl-5,6,7,8-tetrahydro-4H-1-benzothieno(2,3-d)(1,3)oxazin-4-one
-
pH 7.0
0.073
3-(2-cyclohexylethoxy)-4-trifluoroacetylisocoumarin
-
-
0.1
3-(2-cyclohexylethoxy)-7-nitroisocoumarin
-
Ki above 0.1 mM
0.0065
3-butoxy-4-chloroisocoumarin
-
-
0.054
3-cyclohexylmethoxy-7-nitroisocoumarin
-
-
0.1
3-cyclohexylmethyl-4-(trifluoroacetyl)isocoumarin
-
Ki above 0.1 mM
0.025
3-propoxy-4-(trifluoroacetyl)isocoumarin
-
Ki above 0.025 mM
0.0007
4-chloro-3-(2-cyclohexylethoxy)-7-nitroisocoumarin
-
-
0.0012
4-chloro-3-(2-cyclohexylethoxy)isocoumarin
-
-
0.00026
4-chloro-3-(2-cyclopentylethoxy)isocoumarin
-
-
0.00018
4-chloro-3-(3-cyclohexylpropoxy)isocoumarin
-
-
0.000019
4-chloro-3-(3-cyclopentylpropoxy)isocoumarin
-
-
0.000011 - 0.0012
4-chloro-3-(4-cyclohexylbutoxy)isocoumarin
0.00019
4-chloro-3-(4-cyclohexylcyclohexyloxy)isocoumarin
-
-
0.062
4-chloro-3-(5-cyclohexylpentoxy)isocoumarin
-
-
0.0018
4-chloro-3-(cyclohexylmethoxy)isocoumarin
-
-
0.00036
4-chloro-3-(cyclopentylmethoxy)isocoumarin
-
-
0.00095
4-chloro-3-(cyclopentyloxy)isocoumarin
-
-
0.0057
4-chloro-3-cyclohexylmethoxy-7-nitroisocoumarin
-
-
0.019
4-chloro-3-methoxy-7-nitroisocoumarin
-
-
0.0036
4-chloro-3-propoxyisocoumarin
-
-
0.025
4-chloro-7-cyclohexanecarboxamide-3-methoxyisocoumarin
-
Ki above 0.025 mM
0.0038
4-nitrophenyl-N-allyl carbamate
-
pH 7.0, 25°C, pre-steady-state kinetic
0.0026
4-nitrophenyl-N-butyl carbamate
-
pH 7.0, 25°C, pre-steady-state kinetic
0.0058
4-nitrophenyl-N-chloroethyl carbamate
-
pH 7.0, 25°C, pre-steady-state kinetic
0.0032
4-nitrophenyl-N-hexyl carbamate
-
pH 7.0, 25°C, pre-steady-state kinetic
0.0044
4-nitrophenyl-N-methylphenyl carbamate
-
pH 7.0, 25°C, pre-steady-state kinetic
0.0036
4-nitrophenyl-N-octyl carbamate
-
pH 7.0, 25°C, pre-steady-state kinetic
0.000025 - 0.11
6-chloro-3-(2-cyclohexylethyl)-2H-pyran-2-one
0.0008 - 0.24
6-chloro-3-(2-cyclopentylethyl)-2H-pyran-2-one
0.0005 - 0.9
6-chloro-3-(2-cyclopentylethyl)-5-methyl-2H-pyran-2-one
0.00013 - 0.12
6-chloro-3-(2-phenylethyl)-2H-pyran-2-one
0.000063 - 0.011
6-chloro-3-(3-cyclohexylpropyl)-2H-pyran-2-one
0.00021 - 0.0044
6-chloro-3-(4-cyclohexylbutyl)-2H-pyran-2-one
0.0022 - 0.12
6-chloro-3-(cyclohexylmethyl)-2H-pyran-2-one
0.0023 - 0.11
6-chloro-3-cyclohexyl-2H-pyran-2-one
0.00004 - 0.96
6-chloro-3-cyclopentyl-2H-pyran-2-one
0.000058 - 0.16
6-chloro-5-(2-cyclohexylethyl)-3-methyl-2H-pyran-2-one
0.00051
6-chloro-5-methyl-3-(2-phenylethyl)-2H-pyran-2-one
-
pH 7.4, 25°C
0.1
7-amino-3-(2-bromoethoxy)isocoumarin
-
Ki above 0.1 mM
0.017
7-amino-4-chloro-3-methoxyisocoumarin
-
-
0.25
7-benzamido-4-chloro-3-methoxyisocoumarin
-
Ki above 0.25 mM
0.004
benzene-1,2-di-N-benzylcarbamate
-
in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C
0.027
benzene-1,2-di-N-n-butylcarbamate
-
in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C
0.02
benzene-1,2-di-N-n-hexylcarbamate
-
in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C
0.007
benzene-1,2-di-N-n-octylcarbamate
-
in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C
0.03
benzene-1,2-di-N-t-butylcarbamate
-
in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C
0.0017
benzene-1,3-di-N-benzylcarbamate
-
in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C
0.0012
benzene-1,3-di-N-n-butylcarbamate
-
in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C
0.001
benzene-1,3-di-N-n-hexylcarbamate
-
in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C
0.0004
benzene-1,3-di-N-n-octylcarbamate
-
in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C
0.0016
benzene-1,3-di-N-t-butylcarbamate
-
in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C
0.005
benzene-1,4-di-N-benzylcarbamate
-
in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C
0.0018
benzene-1,4-di-N-n-butylcarbamate
-
in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C
0.0012
benzene-1,4-di-N-n-hexylcarbamate
-
in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C
0.0007
benzene-1,4-di-N-n-octylcarbamate
-
in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C
-
0.002
benzene-1,4-di-N-t-butylcarbamate
-
in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C
0.0031
bisphenol A methacrylate
-
pH 7.0, 22°C room temperature
1
dodecylboronic acid
-
-
0.025
heparin
-
for CEase-ISF II
0.00119 - 0.01
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
0.0118 - 0.0187
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]urea
10
phenylboronic acid
-
-
0.1
Phenylmethylsulfonylfluoride
-
-
additional information
additional information
-
inhibition kinetics
-
0.000262
2-(dimethylamino)-5,6,7,8-tetrahydro-4H-[1]benzothieno[2,3-d][1,3]oxazin-4-one
pH 7.0, 30°C, recombinant enzyme
0.00431
2-(dimethylamino)-5,6,7,8-tetrahydro-4H-[1]benzothieno[2,3-d][1,3]oxazin-4-one
pH 7.0, 30°C, recombinant enzyme
0.0000341
2-(dimethylamino)-6,7-dihydro-4H,5H-cyclopenta[4,5]thieno[2,3-d][1,3]oxazin-4-one
pH 7.0, 30°C, recombinant enzyme
0.00434
2-(dimethylamino)-6,7-dihydro-4H,5H-cyclopenta[4,5]thieno[2,3-d][1,3]oxazin-4-one
pH 7.0, 30°C, recombinant enzyme
0.000011
4-chloro-3-(4-cyclohexylbutoxy)isocoumarin
-
-
0.0012
4-chloro-3-(4-cyclohexylbutoxy)isocoumarin
-
-
0.000025
6-chloro-3-(2-cyclohexylethyl)-2H-pyran-2-one
-
pH 7.4, 25°C
0.00073
6-chloro-3-(2-cyclohexylethyl)-2H-pyran-2-one
-
CRL3, pH 7.4, 25°C
0.11
6-chloro-3-(2-cyclohexylethyl)-2H-pyran-2-one
-
CRL1, pH 7.4, 25°C
0.0008
6-chloro-3-(2-cyclopentylethyl)-2H-pyran-2-one
-
pH 7.4, 25°C
0.045
6-chloro-3-(2-cyclopentylethyl)-2H-pyran-2-one
-
CRL3, pH 7.4, 25°C
0.24
6-chloro-3-(2-cyclopentylethyl)-2H-pyran-2-one
-
CRL1, pH 7.4, 25°C
0.0005
6-chloro-3-(2-cyclopentylethyl)-5-methyl-2H-pyran-2-one
-
pH 7.4, 25°C
0.016
6-chloro-3-(2-cyclopentylethyl)-5-methyl-2H-pyran-2-one
-
CRL3, pH 7.4, 25°C
0.053
6-chloro-3-(2-cyclopentylethyl)-5-methyl-2H-pyran-2-one
-
CRL3, pH 7.4, 25°C
0.225
6-chloro-3-(2-cyclopentylethyl)-5-methyl-2H-pyran-2-one
-
CRL1, pH 7.4, 25°C
0.9
6-chloro-3-(2-cyclopentylethyl)-5-methyl-2H-pyran-2-one
-
above, CRL1, pH 7.4, 25°C
0.00013
6-chloro-3-(2-phenylethyl)-2H-pyran-2-one
-
pH 7.4, 25°C
0.096
6-chloro-3-(2-phenylethyl)-2H-pyran-2-one
-
CRL3, pH 7.4, 25°C
0.12
6-chloro-3-(2-phenylethyl)-2H-pyran-2-one
-
CRL1, pH 7.4, 25°C
0.000063
6-chloro-3-(3-cyclohexylpropyl)-2H-pyran-2-one
-
pH 7.4, 25°C
0.00023
6-chloro-3-(3-cyclohexylpropyl)-2H-pyran-2-one
-
CRL3, pH 7.4, 25°C
0.011
6-chloro-3-(3-cyclohexylpropyl)-2H-pyran-2-one
-
CRL1, pH 7.4, 25°C
0.00021
6-chloro-3-(4-cyclohexylbutyl)-2H-pyran-2-one
-
CRL3, pH 7.4, 25°C
0.00058
6-chloro-3-(4-cyclohexylbutyl)-2H-pyran-2-one
-
pH 7.4, 25°C
0.0044
6-chloro-3-(4-cyclohexylbutyl)-2H-pyran-2-one
-
CRL1, pH 7.4, 25°C
0.0022
6-chloro-3-(cyclohexylmethyl)-2H-pyran-2-one
-
pH 7.4, 25°C
0.012
6-chloro-3-(cyclohexylmethyl)-2H-pyran-2-one
-
CRL3, pH 7.4, 25°C
0.12
6-chloro-3-(cyclohexylmethyl)-2H-pyran-2-one
-
CRL1, pH 7.4, 25°C
0.0023
6-chloro-3-cyclohexyl-2H-pyran-2-one
-
pH 7.4, 25°C
0.084
6-chloro-3-cyclohexyl-2H-pyran-2-one
-
CRL3, pH 7.4, 25°C
0.11
6-chloro-3-cyclohexyl-2H-pyran-2-one
-
CRL1, pH 7.4, 25°C
0.00004
6-chloro-3-cyclopentyl-2H-pyran-2-one
-
pH 7.4, 25°C
0.058
6-chloro-3-cyclopentyl-2H-pyran-2-one
-
CRL3, pH 7.4, 25°C
0.96
6-chloro-3-cyclopentyl-2H-pyran-2-one
-
CRL1, pH 7.4, 25°C
0.000058
6-chloro-5-(2-cyclohexylethyl)-3-methyl-2H-pyran-2-one
-
pH 7.4, 25°C
0.013
6-chloro-5-(2-cyclohexylethyl)-3-methyl-2H-pyran-2-one
-
CRL3, pH 7.4, 25°C
0.16
6-chloro-5-(2-cyclohexylethyl)-3-methyl-2H-pyran-2-one
-
CRL1, pH 7.4, 25°C
0.00119
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
pH 7.0, 30°C, recombinant enzyme
0.01
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]urea
pH 7.0, 30°C, recombinant enzyme
0.0118
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]urea
pH 7.0, 30°C, recombinant enzyme
0.0187
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]urea
pH 7.0, 30°C, recombinant enzyme
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0003
(+)-AS115
Mus musculus
pH and temperature not specified in the publication
0.0001
(-)-AS115
Mus musculus
pH and temperature not specified in the publication
0.0794
(1-ethoxy-7-methoxy-1-oxido-1H-2,1-benzoxaphosphinin-3-yl)methanol
Sus scrofa
-
-
0.0636
1-ethoxy-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.0023
1-ethoxy-3-phenyl-4-(phenylethynyl)-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.0303
1-ethoxy-4-iodo-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.0545
1-ethoxy-4-iodo-7-methoxy-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.0774
1-ethoxy-7-methoxy-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.00198
2-(1H-indol-3-yl)-6-nitro-4-phenylquinoline
Sus scrofa
-
at pH 7.0 and 25°C
0.00001085
2-(2,3-dichlorophenyl)-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.00000143
2-(2,4-difluorophenyl)-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.00000681
2-(2,5-difluorophenyl)-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.00000199
2-(2,6-difluorophenyl)-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.00001101
2-(2-bromophenyl)-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.00000322
2-(2-fluorophenyl)-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.00001612
2-(2-iodophenyl)-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.00001408
2-(3,4-difluorophenyl)-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.00472
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one
Sus scrofa
-
at pH 7.0 and 25°C
0.0281
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
Sus scrofa
-
at pH 7.0 and 25°C
0.00000078
2-(3,5-difluorophenyl)-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.00003004
2-(3,5-dinitrophenyl)-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.00002609
2-(3-bromophenyl)-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.02
2-(3-bromophenyl)-6-chloro-4-phenylquinoline
Sus scrofa
-
IC50 above or equal 0.02 mM, at pH 7.0 and 25°C
0.00198
2-(3-bromophenyl)-6-nitro-4-phenylquinoline
Sus scrofa
-
at pH 7.0 and 25°C
0.00000699
2-(3-chlorophenyl)-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.00000524
2-(3-fluorophenyl)-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.00002514
2-(3-nitrophenyl)-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.00002851
2-(4-bromophenyl)-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.0000201
2-(4-fluorophenyl)-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.02
2-(4-hydroxyphenyl)-6-nitro-4-phenylquinoline
Sus scrofa
-
IC50 above or equal 0.02 mM, at pH 7.0 and 25°C
0.00003415
2-(4-iodophenyl)-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.02
2-(4-methylphenyl)-6-nitro-4-phenylquinoline
Sus scrofa
-
IC50 above or equal 0.02 mM, at pH 7.0 and 25°C
0.00003733
2-(4-nitrophenyl)-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.00003898
2-[2-fluoro-4-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.00003889
2-[2-fluoro-6-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.0000404
2-[3,4-bis[(diethoxyphosphinyl)oxy]phenyl]-4-oxo-4H-1-benzopyran-3,5,7-triyl phosphoric acid hexaethyl ester
Sus scrofa
-
at pH 7.0 and 25°C
0.0000367
2-[3,4-bis[(diethoxyphosphinyl)oxy]phenyl]-5-hydroxy-4-oxo-4H-1-benzopyran-3,7-diyl phosphoric acid tetraethyl ester
Sus scrofa
-
at pH 7.0 and 25°C
0.00000389
2-[3,4-bis[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-5,7-diyl tetraethyl bis(phosphate)
Sus scrofa
-
at pH 7.0 and 25°C
0.00004003
2-[3-(chloromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.00004299
2-[3-fluoro-5-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.000206
2-[3-[(diethoxyphosphinyl)oxy]-4-methoxy-phenyl]-4-oxo-4H-1-benzopyran-5,7-diyl phosphoric acid tetraethyl ester
Sus scrofa
-
at pH 7.0 and 25°C
0.00003923
2-[4-(chloromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.00003908
2-[4-fluoro-2-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.00004303
2-[4-fluoro-3-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.0000261
2-[4-[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-5,7-diyl tetraethyl bis(phosphate)
Sus scrofa
-
at pH 7.0 and 25°C
0.00004128
2-[5-fluoro-2-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one
Homo sapiens
at pH 7.0 and 25°C
0.0051
2-[7-chloro-1-ethoxy-3-(4-ethylphenyl)-1-oxido-1H-2,1-benzoxaphosphinin-4-yl]-1-phenylethanone
Sus scrofa
-
-
0.00000418
2-[[4-(diethoxyphosphinyl)oxy]phenyl]-5-hydroxy-4-oxo-4H-1-benzopyran-7-yl phosphoric acid diethyl ester
Sus scrofa
-
at pH 7.0 and 25°C
0.00000073
3-(2,3-dichlorophenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00000146
3-(2,4-difluorophenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00000108
3-(2,5-difluorophenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00000119
3-(2,6-difluorophenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00003135
3-(2-(trifluoromethyl)phenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00000469
3-(2-bromophenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00002311
3-(2-fluoro-4-(trifluoromethyl)phenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00002917
3-(2-fluoro-6-(trifluoromethyl)phenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00000259
3-(2-fluorophenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00000955
3-(2-iodophenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00000115
3-(3,4-difluorophenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00000099
3-(3,5-difluorophenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.0000098
3-(3,5-dinitrophenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00002005
3-(3-(chloromethyl)phenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00000601
3-(3-bromophenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00000083
3-(3-chlorophenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00002911
3-(3-fluoro-5-(trifluoromethyl)phenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.0000039
3-(3-fluorophenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00001644
3-(3-nitrophenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00002223
3-(4-(chloromethyl)phenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00000815
3-(4-bromophenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.0000045
3-(4-fluorophenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00001311
3-(4-iodophenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00001801
3-(4-nitrophenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00002779
3-(5-fluoro-2-(trifluoromethyl)phenyl)-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.0626
3-butyl-1H-2,1-benzoxaphosphinin-1-ol 1-oxide
Sus scrofa
-
-
0.0431
3-butyl-7-chloro-1-ethoxy-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.0963
3-phenyl-1H-2,1-benzoxaphosphinin-1-ol 1-oxide
Sus scrofa
-
-
0.00005106
3-phenyl-1H-benzo[f]chromen-1-one
Homo sapiens
pH and temperature not specified in the publication
0.00000462
3-[[4-(diethoxyphosphinyl)oxy]phenyl]-4-oxo-4H-1-benzopyran-5,7-diyl phosphoric acid tetraethyl ester
Sus scrofa
-
at pH 7.0 and 25°C
0.0000257
3-[[4-(diethoxyphosphinyl)oxy]phenyl]-4-oxo-4H-1-benzopyran-7-yl phosphoric acid diethyl ester
Sus scrofa
-
at pH 7.0 and 25°C
0.00000185
3-[[4-(diethoxyphosphinyl)oxy]phenyl]-5-hydroxy-4-oxo-4H-1-benzopyran-7-yl phosphoric acid diethyl ester
Sus scrofa
-
at pH 7.0 and 25°C
0.0089
4,7-dichloro-1-ethoxy-3-(4-ethylphenyl)-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.0348
4,7-dichloro-1-ethoxy-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.1
4,7-dichloro-3-cyclopropyl-1-ethoxy-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
value above
0.0146
4,7-dichloro-3-phenyl-1H-2,1-benzoxaphosphinin-1-ol 1-oxide
Sus scrofa
-
-
0.0189
4-bromo-1-ethoxy-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.0344
4-bromo-1-ethoxy-7-methoxy-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.0141
4-bromo-3-phenyl-1H-2,1-benzoxaphosphinin-1-ol 1-oxide
Sus scrofa
-
-
0.0064
4-bromo-7-chloro-1-ethoxy-3-(4-ethylphenyl)-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.0479
4-bromo-7-chloro-1-ethoxy-3-(4-methoxyphenyl)-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.0512
4-bromo-7-chloro-1-ethoxy-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.0574
4-bromo-7-methoxy-3-phenyl-1H-2,1-benzoxaphosphinin-1-ol 1-oxide
Sus scrofa
-
-
0.0127
4-chloro-1-ethoxy-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.0896
4-chloro-1-ethoxy-7-methoxy-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.15
4-chloro-3-cyclopropyl-1-ethoxy-7-methoxy-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
value above
0.0019
4-chloro-3-phenyl-1H-2,1-benzoxaphosphinin-1-ol 1-oxide
Sus scrofa
-
-
0.00134
4-oxo-2-phenyl-4H-1-benzopyran-5,6,7-triyl phosphoric acid hexaethyl ester
Sus scrofa
-
at pH 7.0 and 25°C
0.00069
4-oxo-2-phenyl-4H-1-benzopyran-7-yl phosphoric acid dimethyl ester
Sus scrofa
-
at pH 7.0 and 25°C
0.0123
5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one
Sus scrofa
-
at pH 7.0 and 25°C
0.0357
5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
Sus scrofa
-
at pH 7.0 and 25°C
0.0209
5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
Sus scrofa
-
at pH 7.0 and 25°C
0.43
5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-6,7-diyl phosphoric acid tetraethyl ester
Sus scrofa
-
at pH 7.0 and 25°C
0.00000072
5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl phosphoric acid diethyl ester
Sus scrofa
-
at pH 7.0 and 25°C
0.17
5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl phosphoric acid dimethyl ester
Sus scrofa
-
at pH 7.0 and 25°C
0.02
6-chloro-2,4-diphenylquinoline
Sus scrofa
-
IC50 above or equal 0.02 mM, at pH 7.0 and 25°C
0.00133
6-chloro-2-(1H-indol-3-yl)-4-phenylquinoline
Sus scrofa
-
at pH 7.0 and 25°C
0.02
6-chloro-2-(4-hydroxyphenyl)-4-phenylquinoline
Sus scrofa
-
IC50 above or equal 0.02 mM, at pH 7.0 and 25°C
0.02
6-chloro-2-(4-methoxyphenyl)-4-phenylquinoline
Sus scrofa
-
IC50 above or equal 0.02 mM, at pH 7.0 and 25°C
0.02
6-chloro-2-(4-methylphenyl)-4-phenylquinoline
Sus scrofa
-
IC50 above or equal 0.02 mM, at pH 7.0 and 25°C
0.02
6-nitro-2,4-diphenylquinoline
Sus scrofa
-
IC50 above or equal 0.02 mM, at pH 7.0 and 25°C
0.0403
7-chloro-1-ethoxy-3-(4-ethylphenyl)-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.0085
7-chloro-1-ethoxy-3-(4-ethylphenyl)-4-(phenylethynyl)-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.0048
7-chloro-1-ethoxy-3-(4-ethylphenyl)-4-iodo-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.1
7-chloro-1-ethoxy-3-(4-nitrophenyl)-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
value above
0.0569
7-chloro-1-ethoxy-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.0262
7-chloro-1-ethoxy-4-iodo-3-(4-methoxyphenyl)-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.0479
7-chloro-1-ethoxy-4-iodo-3-phenyl-1H-2,1-benzoxaphosphinine 1-oxide
Sus scrofa
-
-
0.0584
7-chloro-3-(4-ethylphenyl)-1H-2,1-benzoxaphosphinin-1-ol 1-oxide
Sus scrofa
-
-
0.0387
7-chloro-3-phenyl-1H-2,1-benzoxaphosphinin-1-ol 1-oxide
Sus scrofa
-
-
0.1025
7-methoxy-3-phenyl-1H-2,1-benzoxaphosphinin-1-ol 1-oxide
Sus scrofa
-
-
0.0023
76-0079
Mus musculus
pH and temperature not specified in the publication
-
0.00039
diethyl 4-oxo-2-phenyl-4H-chromen-6-yl phosphate
Sus scrofa
-
at pH 7.0 and 25°C
0.00000244
diethyl 4-oxo-2-phenyl-4H-chromen-7-yl phosphate
Sus scrofa
-
at pH 7.0 and 25°C
0.00027
dimethyl 5-hydroxy-4-oxo-2-phenyl-4H-chromen-4',7-yl phosphate
Sus scrofa
-
at pH 7.0 and 25°C
0.000003
paraoxon
Mus musculus
pH and temperature not specified in the publication
0.00000376
tetraethyl 4-oxo-2-phenyl-4H-chromene-5,7-diyl bis(phosphate)
Sus scrofa
-
at pH 7.0 and 25°C
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