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2-chloro-5,5-dimethyl-1,3-cyclohexanedimedon + Br- + acetic acid + H2O2
2-chloro-2-bromo-5,5-dimethyl-1,3-cyclohexanedimedon + acetic acid + H2O
2-chloro-5,5-dimethyl-1,3-cyclohexanedimedon + Br- + peracetic acid
2-chloro-2-bromo-5,5-dimethyl-1,3-cyclohexanedimedon + acetic acid + H2O
3,4-dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
3,4-dihydrocoumarin + H2O
?
3,4-dihydrocoumarin + H2O
melilotate
3H-benzofuran-2-one + H2O
2-hydroxyphenylacetic acid
-
16% of the activity compared to 7-hydroxydihydrocoumarin
-
-
?
5-hydroxy-3H-benzofuran-2-one + H2O
homogentisic acid
-
82% of the activity compared to 7-hydroxydihydrocoumarin
-
-
?
6,7-dihydroxydihydrocoumarin + H2O
3-(2,3,6-trihydroxyphenyl)propionic acid
7,8-dihydroxydihydrocoumarin + H2O
3-(3,4,6-trihydroxyphenyl)propionic acid
-
8% of the activity compared to 7-hydroxydihydrocoumarin
-
-
?
7-hydroxy-6-methoxydihydrocoumarin + H2O
3-(2,3-dihydroxy-3-methoxyphenyl)propionic acid
-
43% of the activity compared to 7-hydroxydihydrocoumarin
-
-
?
7-hydroxydihydrocoumarin + H2O
?
-
most rapidly hydrolyzed
-
-
?
delta-D-gluconolactone + H2O
D-gluconate
-
0.8% of the activity compared to 7-hydroxydihydrocoumarin
-
-
?
delta-valerolactone + H2O
5-hydroxypentanoate
-
0.3% of the activity compared to 7-hydroxydihydrocoumarin
-
-
?
dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
dihydrocoumarin + H2O
melilotate
dimethyl-(R)-methylsuccinate + H2O
(R)-methylsuccinate + methanol
DL-beta-acetylthioisobutyrate methyl ester + H2O
D-beta-acetylthioisobutyrate + methanol
DL-methyl-2-chloropropionate + H2O
2-chloropropionate + methanol
gentisic acid gamma-lactone
?
methyl cetraxate hydrochloride + H2O
cetraxate hydrochloride + methanol
methyl-(R)-3-bromo-2-methylpropionate + H2O
(R)-3-bromomethylpropionate + methanol
methyl-3(4-hydroxyphenyl)-propionate + H2O
3-(4-hydroxyphenyl)-propionate + methanol
-
18.5% of activity with methyl-DL-beta-acetylthioisobutyrate
-
?
methyl-DL-beta-acetylthioisobutyrate + H2O
D-beta-acetylthioisobutyrate + methanol
peracetic acid
acetic acid + H2O
peracetic acid is likely a natural substrate in vivo, enzyme may play a role in oxidative stress defense system
-
?
additional information
?
-
-
no hydrolysis with gamma-butyrolactone as substrate
-
-
?
2-chloro-5,5-dimethyl-1,3-cyclohexanedimedon + Br- + acetic acid + H2O2
2-chloro-2-bromo-5,5-dimethyl-1,3-cyclohexanedimedon + acetic acid + H2O
-
-
-
?
2-chloro-5,5-dimethyl-1,3-cyclohexanedimedon + Br- + acetic acid + H2O2
2-chloro-2-bromo-5,5-dimethyl-1,3-cyclohexanedimedon + acetic acid + H2O
-
-
-
?
2-chloro-5,5-dimethyl-1,3-cyclohexanedimedon + Br- + peracetic acid
2-chloro-2-bromo-5,5-dimethyl-1,3-cyclohexanedimedon + acetic acid + H2O
-
-
-
?
2-chloro-5,5-dimethyl-1,3-cyclohexanedimedon + Br- + peracetic acid
2-chloro-2-bromo-5,5-dimethyl-1,3-cyclohexanedimedon + acetic acid + H2O
-
-
?
2-chloro-5,5-dimethyl-1,3-cyclohexanedimedon + Br- + peracetic acid
2-chloro-2-bromo-5,5-dimethyl-1,3-cyclohexanedimedon + acetic acid + H2O
-
-
-
?
2-chloro-5,5-dimethyl-1,3-cyclohexanedimedon + Br- + peracetic acid
2-chloro-2-bromo-5,5-dimethyl-1,3-cyclohexanedimedon + acetic acid + H2O
-
-
?
2-coumaranone
?
-
low activity
-
-
?
2-coumaranone
?
-
low activity
-
-
?
3,4-dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
-
-
-
?
3,4-dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
-
-
-
?
3,4-dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
-
-
?
3,4-dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
-
-
trivial name melilotate
?
3,4-dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
-
-
trivial name melilotate
?
3,4-dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
-
-
-
?
3,4-dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
-
-
-
?
3,4-dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
-
-
?
3,4-dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
-
-
-
-
?
3,4-dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
-
-
-
-
?
3,4-dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
-
-
-
-
?
3,4-dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
-
-
-
-
?
3,4-dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
-
-
-
-
?
3,4-dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
-
60% of the activity compared to 7-hydroxydihydrocoumarin
-
-
?
3,4-dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
-
-
-
-
?
3,4-dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
-
-
-
-
?
3,4-dihydrocoumarin + H2O
?
-
key enzyme in the metabolism in the degradation of fluorene. The product could be a substrate for a beta oxidation cycle, to give salicylate
-
-
?
3,4-dihydrocoumarin + H2O
?
-
key enzyme in the metabolism in the degradation of fluorene. The product could be a substrate for a beta oxidation cycle, to give salicylate
-
-
?
3,4-dihydrocoumarin + H2O
?
-
coumarin is converted to dihydrocoumarin by hydrogenation
-
-
?
3,4-dihydrocoumarin + H2O
melilotate
-
the enzyme is specific for 3,4-dihydrocoumarin
-
-
?
3,4-dihydrocoumarin + H2O
melilotate
-
the enzyme is specific for 3,4-dihydrocoumarin
-
-
?
6,7-dihydroxydihydrocoumarin + H2O
3-(2,3,6-trihydroxyphenyl)propionic acid
-
6% of the activity compared to 7-hydroxydihydrocoumarin
-
-
?
6,7-dihydroxydihydrocoumarin + H2O
3-(2,3,6-trihydroxyphenyl)propionic acid
-
i.e. escelutin
-
-
?
dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
-
-
trivial name melilotate
?
dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
-
-
trivial name melilotate
?
dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
-
-
trivial name melilotate
?
dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propionic acid
-
-
trivial name melilotate
?
dihydrocoumarin + H2O
melilotate
-
-
-
?
dihydrocoumarin + H2O
melilotate
-
-
?
dihydrocoumarin + H2O
melilotate
-
-
?
dimethyl-(R)-methylsuccinate + H2O
(R)-methylsuccinate + methanol
-
20.7% of activity with methyl-DL-beta-acetylthioisobutyrate
-
?
dimethyl-(R)-methylsuccinate + H2O
(R)-methylsuccinate + methanol
-
20.7% of activity with methyl-DL-beta-acetylthioisobutyrate
-
?
DL-beta-acetylthioisobutyrate methyl ester + H2O
D-beta-acetylthioisobutyrate + methanol
stereospecific hydrolysis
-
?
DL-beta-acetylthioisobutyrate methyl ester + H2O
D-beta-acetylthioisobutyrate + methanol
-
stereospecific hydrolysis
99% enatiomeric excess
?
DL-beta-acetylthioisobutyrate methyl ester + H2O
D-beta-acetylthioisobutyrate + methanol
-
stereospecific hydrolysis, 3.8% of activity with 3,4-dihydrocoumarin
99% enatiomeric excess
?
DL-beta-acetylthioisobutyrate methyl ester + H2O
D-beta-acetylthioisobutyrate + methanol
-
stereospecific hydrolysis, 3.8% of activity with 3,4-dihydrocoumarin
99% enatiomeric excess
?
DL-beta-acetylthioisobutyrate methyl ester + H2O
D-beta-acetylthioisobutyrate + methanol
-
stereospecific hydrolysis
99% enatiomeric excess
?
DL-beta-acetylthioisobutyrate methyl ester + H2O
D-beta-acetylthioisobutyrate + methanol
stereospecific hydrolysis
-
?
DL-methyl-2-chloropropionate + H2O
2-chloropropionate + methanol
-
1.6% of activity with methyl-DL-beta-acetylthioisobutyrate
-
?
DL-methyl-2-chloropropionate + H2O
2-chloropropionate + methanol
-
1.6% of activity with methyl-DL-beta-acetylthioisobutyrate
-
?
gentisic acid gamma-lactone
?
-
low activity
-
-
?
gentisic acid gamma-lactone
?
-
low activity
-
-
?
methyl cetraxate hydrochloride + H2O
cetraxate hydrochloride + methanol
-
-
-
?
methyl cetraxate hydrochloride + H2O
cetraxate hydrochloride + methanol
-
-
-
?
methyl cetraxate hydrochloride + H2O
cetraxate hydrochloride + methanol
-
-
-
?
methyl-(R)-3-bromo-2-methylpropionate + H2O
(R)-3-bromomethylpropionate + methanol
-
3.5% of activity with methyl-DL-beta-acetylthioisobutyrate
-
?
methyl-(R)-3-bromo-2-methylpropionate + H2O
(R)-3-bromomethylpropionate + methanol
-
3.5% of activity with methyl-DL-beta-acetylthioisobutyrate
-
?
methyl-DL-beta-acetylthioisobutyrate + H2O
D-beta-acetylthioisobutyrate + methanol
-
stereospecific hydrolysis
-
?
methyl-DL-beta-acetylthioisobutyrate + H2O
D-beta-acetylthioisobutyrate + methanol
-
stereospecific hydrolysis
-
?
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Kosuge, T.; Conn, E.
The metabolism of aromatic compounds in higher plants
J. Biol. Chem.
237
1653-1656
1962
Anthoxanthum occidentale, Medicago sativa, Melilotus albus, Melilotus officinalis, no activity in Hordeum vulgare, Trifolium pratense, Anthoxanthum occidentale Buckl.
brenda
Casellas, M.; Grifoll, M.; Bayona, J.M.; Solanas, A.M.
New metabolites in the degradation of fluorene by Arthrobacter sp. strain F101
Appl. Environ. Microbiol.
63
819-826
1997
Arthrobacter sp., Arthrobacter sp. F101
brenda
Honda, K.; Kataoka, M.; Shimizu, S.
Enzymatic preparation of D-beta-acetylthioisobutyric acid and cetraxate hydrochloride using a stereo-and/or regioselective hydrolase, 3,4-dihydrocoumarin hydrolase from Acinetobacter calcoaceticus
Appl. Microbiol. Biotechnol.
60
288-292
2002
Acinetobacter calcoaceticus, Acinetobacter calcoaceticus F45
brenda
Kataoka, M.; Honda, K.; Shimizu, S.
3,4-Dihydrocoumarin hydrolase with haloperoxidase activity from Acinetobacter calcoaceticus F46
Eur. J. Biochem.
267
3-10
2000
Acinetobacter calcoaceticus, Acinetobacter calcoaceticus F46
brenda
Honda, K.; Kataoka, M.; Sakuradani, E.; Shimizu, S.
Role of Acinetobacter calcoaceticus 3,4-dihydrocoumarin hydrolase in oxidative stress defence against peroxoacids
Eur. J. Biochem.
270
486-494
2003
Acinetobacter calcoaceticus (Q83WC8), Acinetobacter calcoaceticus, Acinetobacter calcoaceticus F46 (Q83WC8), Acinetobacter calcoaceticus F46
brenda
Kataoka, M.; Honda, K.; Shimizu, S.
A novel dihydrocoumarin hydrolase from Acinetobacter calcoaceticus: application to the production of useful compounds
J. Mol. Catal. B
19-20
231-235
2002
Acinetobacter calcoaceticus, Acinetobacter calcoaceticus F46
-
brenda
Giedraityte, G.; Kalediene, L.
3,4-Dihydrocoumarin hydrolase from thermophilic Geobacillus sp. strain
Rom. Biotechnol. Lett.
17
7104-7113
2012
Geobacillus sp., Geobacillus sp. G27
-
brenda