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1,2-didecanoyl-sn-glycerol + H2O
?
1,2-dioctanoyl-sn-glycerol + H2O
?
1,2-dioctanoylethyleneglycol + H2O
?
1-acetyl-2-hexadecyl-sn-glycero-3-phosphocholine + H2O
2-hexadecyl-sn-glycero-3-phosphocholine + acetate
1-acyl-2-linoleoyl-glycero-phosphocholine + H2O
2-linoleoyl-glycero-phosphocholine + acylic acid
-
-
-
?
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
1-decanoyl-rac-glycerol + H2O
?
-
-
-
?
1-decanoyl-rac-glycerol + H2O
decanoate + glycerol
-
-
-
?
1-hexadecyl-2-acetyl-sn-glycerol-3-phosphocholine + H2O
1-hexadecyl-sn-glycerol-3-phosphocholine + acetate
1-hexadecyl-2-butyryl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-glycero-3-phosphocholine + butanoate
-
-
-
?
1-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-glycero-3-phosphocholine + glutarate
1-hexadecyl-2-propionyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-glycero-3-phosphocholine + propionate
-
-
-
?
1-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-glycero-3-phosphocholine + succinate
1-myristoyl-2-(4-nitrophenyl succinyl)phosphatidylcholine + H2O
1-myristoyl-phosphatidylcholine + 4-nitrophenyl succinate
-
artificial substrate
4-nitrophenyl succinate spontaneously degrades and liberates 4-nitrophenol
?
1-myristoyl-2-(4-nitrophenylsuccinyl)-3-phosphatidylcholine + H2O
1-myristoyl-3-phosphatidylcholine + 4-nitrophenylsuccinate
-
-
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
preferred substrate for the alpha1/alpha1 homodimer and the alpha1/alpha2 heterodimer
-
?
1-O-alkyl-2-butyryl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + butanoate
-
-
-
?
1-O-alkyl-2-propionyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + propanoate
-
-
-
?
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-hexadecyl-sn-glycerol-3-phosphocholine + acetate
1-O-hexadecyl-2-N-methylcarbamoyl-sn-glycero-3-phospho(N,N,N-trimethyl)hexanolamine
?
-
-
-
-
?
1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
-
-
-
?
1-octanoyl-rac-glycerol + H2O
?
-
-
-
?
1-octanoyl-rac-glycerol + H2O
octanoate + glycerol
-
-
-
?
1-oleoyl-2-acetyl-sn-glycerol + H2O
1-oleoyl-sn-glycerol + acetate
1-palmitoyl-2(5-oxovaleroyl)-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate
-
plasma isozyme
-
?
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine + H2O
5-oxopentanoate + 1-palmitoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + arachidonate
-
plasma isozyme
-
?
1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + glutarate
-
plasma isozyme
-
?
1-palmitoyl-2-oxopentanoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + 2-oxopentanoate
-
-
-
?
1-palmitoyl-2-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sn-glycero-3-phosphocholine + H2O
?
-
substrate activity assay
-
-
?
1-palmitoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycero-3-phosphocholine + H2O
?
-
substrate activity assay
-
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecanoyl-sn-glycero-3-phosphocholine
1-hexadecyl-sn-glycero-3-phosphocholine + 2-acetyl-1-hexadecanoyl-sn-glycero-3-phosphocholine
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine
1-hexadecyl-sn-glycero-3-phosphocholine + 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
2-acetyl-1-O-alkyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, hydrolysis of sn-2 ester bond of platelet-activating factor PAF and related inflammatory phospholipids, no activity with the erythrocyte isozyme
-
?
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O
1-O-alkyl-sn-glycero-3-phosphoethanolamine + acetate
-
-
-
?
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine + H2O
1-octadecyl-sn-glycero-3-phosphocholine + acetate
2-acetyl-3-octadecyl-sn-glycero-1-phosphocholine + H2O
3-octadecyl-sn-glycero-1-phosphocholine + acetate
2-butanoyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine
1-hexadecyl-sn-glycero-3-phosphocholine + 2-butanoyl-1-hexadecyl-sn-glycero-3-phosphocholine
-
transacetylase activity, 40% of the activity with PAF
-
?
2-hexadecyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
2-propionyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine
1-hexadecyl-sn-glycero-3-phosphocholine + 2-propionyl-1-hexadecyl-sn-glycero-3-phosphocholine
-
transacetylase activity, 73% of the activity with PAF
-
?
2-thio platelet-activating factor + H2O
?
-
substrate activity assay
-
-
?
2-thio-[platelet activating factor] + H2O
acetate + deacetylated 2-thio-[platelet activating factor]
-
-
-
-
?
2-valeroyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine
1-hexadecyl-sn-glycero-3-phosphocholine + 2-valeroyl-1-hexadecyl-sn-glycero-3-phosphocholine
-
transacetylase activity, 17% of the activity with PAF
-
?
3-O-hexadecyl-2-acetyl-sn-glycero-1-phosphocholine + H2O
3-O-hexadecyl-sn-glycero-1-phosphocholine + acetate
4-(phenylthio)-N-(4-phenyl-2-oxobutyl)azetidin-2-one + H2O
thiophenol + 3-oxopropanoic acid + 1-amino-4-phenyl-2-butanone
-
-
-
?
acetylated platelet-activation factor + H2O
?
-
-
-
?
azelaoyl phosphatidylcholine + H2O
?
-
-
-
-
?
butyl acetate + H2O
butanol + acetate
dibutanoyl-phosphocholine + H2O
?
-
-
-
-
?
dibutyryl-phosphocholine + H2O
?
didecanoyl-phosphocholine + H2O
?
dioctanoyl-phosphocholine + H2O
?
F2-isoprostane phospholipid + H2O
F2-isoprostane + phospholipid
-
plays key roles in the hydrolysis of F2-isoprostanes esterified on phospholipids in vivo, involved in oxidative stress response
-
-
?
F2-isoprostane-phosphocholine + H2O
?
-
-
-
-
?
lipoteichoic acid + H2O
?
-
PAF-AH removes one acyl chain at the sn-2 position of pneumococcal lipoteichoic acid and produces a monoacyl-LTA that is inactive against mouse cells
-
-
?
methyl butyrate + H2O
methanol + butyrate
octyl acetate + H2O
octanol + acetate
oxidized phosphatidylcholine + H2O
?
-
-
-
?
oxidized phospholipids + H2O
?
phospholipid + H2O
?
-
degradation of phospholipids produced by oxidative stress
-
-
?
platelet activating factor + H2O
acetate + deacetylated platelet activating factor
platelet-activating factor + H2O
?
platelet-activating factor + H2O
lyso-platelet-activating factor + acetate
-
-
-
-
?
triacetylglycerol + H2O
diacetylglycerol + acetate
tributyrylglycerol + H2O
dibutyrylglycerol + butyrate
trioctanoylglycerol + H2O
dioctanoylglycerol + octanoate
additional information
?
-
1,2-didecanoyl-sn-glycerol + H2O
?
-
-
-
?
1,2-didecanoyl-sn-glycerol + H2O
?
-
-
-
?
1,2-dioctanoyl-sn-glycerol + H2O
?
-
-
-
?
1,2-dioctanoyl-sn-glycerol + H2O
?
-
-
-
?
1,2-dioctanoylethyleneglycol + H2O
?
-
-
-
?
1,2-dioctanoylethyleneglycol + H2O
?
-
-
-
?
1-acetyl-2-hexadecyl-sn-glycero-3-phosphocholine + H2O
2-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
-
-
?
1-acetyl-2-hexadecyl-sn-glycero-3-phosphocholine + H2O
2-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
-
-
?
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
-
-
-
?
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
-
-
-
?
1-hexadecyl-2-acetyl-sn-glycerol-3-phosphocholine + H2O
1-hexadecyl-sn-glycerol-3-phosphocholine + acetate
-
i.e. PAF
-
?
1-hexadecyl-2-acetyl-sn-glycerol-3-phosphocholine + H2O
1-hexadecyl-sn-glycerol-3-phosphocholine + acetate
-
i.e. PAF
-
?
1-hexadecyl-2-acetyl-sn-glycerol-3-phosphocholine + H2O
1-hexadecyl-sn-glycerol-3-phosphocholine + acetate
-
i.e. PAF
-
?
1-hexadecyl-2-acetyl-sn-glycerol-3-phosphocholine + H2O
1-hexadecyl-sn-glycerol-3-phosphocholine + acetate
-
i.e. PAF
-
?
1-hexadecyl-2-acetyl-sn-glycerol-3-phosphocholine + H2O
1-hexadecyl-sn-glycerol-3-phosphocholine + acetate
-
i.e. PAF
-
?
1-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-glycero-3-phosphocholine + glutarate
-
-
-
?
1-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-glycero-3-phosphocholine + glutarate
-
-
-
?
1-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-glycero-3-phosphocholine + glutarate
-
-
-
?
1-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-glycero-3-phosphocholine + glutarate
-
-
-
?
1-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-glycero-3-phosphocholine + succinate
-
-
-
?
1-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-glycero-3-phosphocholine + succinate
-
-
-
?
1-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-glycero-3-phosphocholine + succinate
-
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. PAF
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. PAF
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
preferred substrate for alpha2/alpha2 homodimer of brain isoform I
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor, protection against toxic effects of platelet-activating factor
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
platelet-activating factor
lyso-platelet-activating factor
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
regulation of platelet-activating factor, essential for epithelial morphogenesis
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. PAF
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. PAF
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. PAF
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
inactivation of platelet-activating factor, up-regulation of enzyme by pioglitazone reduces cell elongation
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor, anti-inflammatory enzyme
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor, enzyme could play an important role in the development or down regulation of inflammation in acute respiratory distress syndrome
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor, important role in inflammation and in atherosclerotic processes related to the metabolic syndrome
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
platelet-activating factor
lyso-platelet-activating factor
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. PAF
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
-
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. PAF
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
regulation of platelet-activating factor, anti apoptotic protein
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
enzyme from red blood cells is not involved in the degradation of platelet-activating factor accumulated in blood
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
-
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
the substrate is a potent inflammatory mediator
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
inactivation of the substrate which represents a wide variety of bioactivities, including hypotension, platelat activation, bronchoconstriction
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
-
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
i.e. PAF
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
the enzyme abolishes the inflammatory effects of the substrate on leukocytes and the vasculature
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
the substrate mediates a wide spectrum of actions, including hypotension, changes in smooth muscle tone, vascular permeability, signalling in inflammation and allergy. The intracelluar form of the enzyme regulates the accumulation of the substrate, e.g. in macrophages and platelets
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
the substrate is a potent lipid mediator, involved in pathological responses, particularly in inflammation and allergy. Its level is regulated by hydrolysis
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
i.e. PAF
-
-
?
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-hexadecyl-sn-glycerol-3-phosphocholine + acetate
-
-
-
-
?
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-hexadecyl-sn-glycerol-3-phosphocholine + acetate
-
-
-
-
?
1-oleoyl-2-acetyl-sn-glycerol + H2O
1-oleoyl-sn-glycerol + acetate
-
-
-
?
1-oleoyl-2-acetyl-sn-glycerol + H2O
1-oleoyl-sn-glycerol + acetate
-
-
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
biological inactivation of the platelet-activation factor by hydrolysis of the acetyl group at sn-2 position which is essential for activity of PAF
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
-
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor PAF, hydrolysis of the acetyl ester at the sn-2 position, conversion to the inactive lysoPAF
i.e. lysoPAF
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibits the initiation of inflammation processes
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
-
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor PAF, hydrolysis of the acetyl ester at the sn-2 position, conversion to the inactive lysoPAF
i.e. lysoPAF
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
enzyme plays an important role in inflammatory diseases and artherosclerosis, and is involved in non-insulin dependent diabetes mellitus, the level of free, LDL- and/or HDL-associated enzyme is important, overview
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, a mediator of several vascular and inflammatory diseases
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, hydrolysis of sn-2 ester bond of platelet-activating factor PAF and related inflammatory phospholipids, attenuation of their bioactivity, the beta-subunit of intracellular isozyme type II is encoded by gene LIS1, mutations of which cause Miller-Dieker lissencephaly
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, the enzyme converts the proinflammatory autocoid platelet-activating factor PAF into biologically inactive lyso-PAF, by the removal of the sn-2 acetyl group
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
the enzyme is essential for metabolism of platelet-activation factor and phospholipids, i.e. bioactive lipids that are involved in the pathophysiology of arherosclerosis
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, a mediator of several vascular and inflammatory diseases
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibitsthe initiation of inflammation processes
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibitsthe initiation of inflammation processes
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
-
-
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, hyperoxemic rats show reduced enzyme activity in bronchoalveolar lavage and slightly increased levels in the plasma
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibitsthe initiation of inflammation processes
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, the enzyme hydrolyzes and inactivates platelet-activating factor PAF and PAF-like phospholipids which are implicated in numerous pathological situations including bacterial endotoxemia and injury-induced oxidative damage
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecanoyl-sn-glycero-3-phosphocholine
1-hexadecyl-sn-glycero-3-phosphocholine + 2-acetyl-1-hexadecanoyl-sn-glycero-3-phosphocholine
-
transacetylase activity
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecanoyl-sn-glycero-3-phosphocholine
1-hexadecyl-sn-glycero-3-phosphocholine + 2-acetyl-1-hexadecanoyl-sn-glycero-3-phosphocholine
-
transacetylation
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine
1-hexadecyl-sn-glycero-3-phosphocholine + 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine
-
transacetylase activity
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine
1-hexadecyl-sn-glycero-3-phosphocholine + 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine
-
the transacetylase activity may acetylate extracellular lyso-PAF into biologically active PAF
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
-
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
-
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor PAF
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, biological inactivation by deacetylation
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
-
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
-
-
?
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
-
-
?
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
-
-
?
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
-
-
?
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
-
-
?
2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine + H2O
1-octadecyl-sn-glycero-3-phosphocholine + acetate
-
-
-
?
2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine + H2O
1-octadecyl-sn-glycero-3-phosphocholine + acetate
-
-
-
?
2-acetyl-3-octadecyl-sn-glycero-1-phosphocholine + H2O
3-octadecyl-sn-glycero-1-phosphocholine + acetate
-
-
-
?
2-acetyl-3-octadecyl-sn-glycero-1-phosphocholine + H2O
3-octadecyl-sn-glycero-1-phosphocholine + acetate
-
-
-
?
2-hexadecyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-hexadecyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, substrate and enzyme play important roles in inflammation processes
-
?
3-O-hexadecyl-2-acetyl-sn-glycero-1-phosphocholine + H2O
3-O-hexadecyl-sn-glycero-1-phosphocholine + acetate
-
-
-
-
?
3-O-hexadecyl-2-acetyl-sn-glycero-1-phosphocholine + H2O
3-O-hexadecyl-sn-glycero-1-phosphocholine + acetate
-
-
-
-
?
butyl acetate + H2O
butanol + acetate
-
-
-
?
butyl acetate + H2O
butanol + acetate
-
-
-
?
dibutyryl-phosphocholine + H2O
?
-
-
-
?
dibutyryl-phosphocholine + H2O
?
-
-
-
?
didecanoyl-phosphocholine + H2O
?
-
-
-
?
didecanoyl-phosphocholine + H2O
?
-
-
-
?
dioctanoyl-phosphocholine + H2O
?
-
-
-
?
dioctanoyl-phosphocholine + H2O
?
-
-
-
?
methyl butyrate + H2O
methanol + butyrate
-
-
-
?
methyl butyrate + H2O
methanol + butyrate
-
-
-
?
octyl acetate + H2O
octanol + acetate
-
-
-
?
octyl acetate + H2O
octanol + acetate
-
-
-
?
oxidized phospholipids + H2O
?
-
protection against toxic effects of oxidized phospholipids
-
-
?
oxidized phospholipids + H2O
?
-
-
-
-
?
oxidized phospholipids + H2O
?
-
degradation of oxidized phospholipids formed during the oxidative modification of low-density lipoprotein
-
-
?
phospholipids + H2O
?
-
hydrolyzes sn-2-ester bonds of fragmented or oxidized phospholipids, enzyme deficiency results in an increased risk of stroke, coronary artery disease, atherosclerotic occlusive disease, and abdominal aortic aneurysm
-
-
?
phospholipids + H2O
?
-
hydrolyzes sn-2-ester bonds of fragmented or oxidized phospholipids
-
-
?
platelet activating factor + H2O
acetate + deacetylated platelet activating factor
-
erythrocyte and plasma PAF acetylhydrolases
-
-
?
platelet activating factor + H2O
acetate + deacetylated platelet activating factor
-
-
-
-
?
platelet-activating factor + H2O
?
-
-
-
-
?
platelet-activating factor + H2O
?
-
-
-
?
platelet-activating factor + H2O
?
-
-
-
-
?
platelet-activating factor + H2O
?
-
-
-
-
?
triacetylglycerol + H2O
diacetylglycerol + acetate
-
-
-
?
triacetylglycerol + H2O
diacetylglycerol + acetate
-
-
-
?
tributyrylglycerol + H2O
dibutyrylglycerol + butyrate
-
-
-
?
tributyrylglycerol + H2O
dibutyrylglycerol + butyrate
-
-
-
?
trioctanoylglycerol + H2O
dioctanoylglycerol + octanoate
-
-
-
?
trioctanoylglycerol + H2O
dioctanoylglycerol + octanoate
-
-
-
?
additional information
?
-
-
no activity against phosphatidylcholine or phosphatidylethanolamine, but hydrolysis of a phosphatidylcholine with an oxidatively fragmented acyl chain at the sn-2 position
-
-
?
additional information
?
-
-
substrate specificity, mammalian isozyme II possesses transacetylase activity as well
-
?
additional information
?
-
enzyme plays a critical role in control of neuronal migration during cortex development
-
?
additional information
?
-
-
enzyme plays a critical role in control of neuronal migration during cortex development
-
?
additional information
?
-
-
one of the physiological roles of isozyme II is to diversify the biological function of PAF by producing different lipid mediators such as analogues of PAF and C2-ceramide, mutations of the gene encoding the enzyme lead to severe diseases, e.g. brain impairment, mental retardation, or lymphoma development
-
?
additional information
?
-
selectively hydrolyzes oxidatively modified phosphatidylcholine. The purified enzyme does not degrade phospholipids with a long chain fatty acyl group at the sn-2 position
-
-
?
additional information
?
-
-
selectively hydrolyzes oxidatively modified phosphatidylcholine. The purified enzyme does not degrade phospholipids with a long chain fatty acyl group at the sn-2 position
-
-
?
additional information
?
-
-
PAF-like oxidatively fragmented phospholipids produced during oxidative stress
-
-
?
additional information
?
-
-
hydrolyzes also propionyl and butyloyl groups from phosphoglycerides, and truncated acyl chains derived from oxidative cleavage of long-chain polyunsaturated fatty acyl groups, suggesting that they have a role in scavenging selectively oxidized phospholipid species without acting on structural membrane phospholipids
-
-
?
additional information
?
-
hydrolyzes also propionyl and butyloyl groups from phosphoglycerides, and truncated acyl chains derived from oxidative cleavage of long-chain polyunsaturated fatty acyl groups, suggesting that they have a role in scavenging selectively oxidized phospholipid species without acting on structural membrane phospholipids
-
-
?
additional information
?
-
-
hydrolyzes also propionyl and butyryl groups from phosphoglycerides, and truncated acyl chains derived from oxidative cleavage of long-chain polyunsaturated fatty acyl groups, suggesting that they have a role in scavenging selectively oxidized phospholipid species without acting on structural membrane phospholipids
-
-
?
additional information
?
-
hydrolyzes also propionyl and butyryl groups from phosphoglycerides, and truncated acyl chains derived from oxidative cleavage of long-chain polyunsaturated fatty acyl groups, suggesting that they have a role in scavenging selectively oxidized phospholipid species without acting on structural membrane phospholipids
-
-
?
additional information
?
-
-
no hydrolysis of long acyl chains attached to phosphatidylcholine
-
-
?
additional information
?
-
no hydrolysis of long acyl chains attached to phosphatidylcholine
-
-
?
additional information
?
-
-
substrate specificity of the enzyme forms and isoenzyme types
-
?
additional information
?
-
-
physiological functions of isozymes, overview
-
?
additional information
?
-
-
the erythrocyte enzyme has a marked selectivity for short-chain acyl chains at sn-2 position, the linkage at the sn-1 postion may be of the ester or ether type and does not influence the catalytic effeciency
-
-
?
additional information
?
-
-
cholesteryl acetate is inactive as acetyl donor in the transacetylation reaction
-
?
additional information
?
-
-
enzyme of sarcoma cell line inhibits neoangiogenesis and endothelial tubulogenesis in vitro, overview
-
?
additional information
?
-
-
isozyme II from cerebrospinal fluid does not degrade phospholipids with a long chain fatty acyl group at sn-2 position
-
?
additional information
?
-
-
lipoprotein-associated enzyme does not hydrolyse native phospholipids
-
?
additional information
?
-
-
lipoprotein-associated phospholipase A2 activity
-
?
additional information
?
-
-
plasma isozyme and isozyme II shows also transacetylase activity, broad substrate specificity, plasma isozyme and isozyme II prefer PAF analogues with sn-2 propionyl and butyroyl moieties, while isozyme Ib hardly hydrolyzes these phospholipids, plasma isozyme hydrolyzes preferentially phosphatidylcholine with C9 acyl chain, activity is increased in the presence of an aldehyde group at the omega-end of the acyl chain
-
?
additional information
?
-
-
substrate specificity of isozymes, overview
-
?
additional information
?
-
-
substrate specificity of the enzyme forms and isoenzyme types, the isozyme Ib interacts with some plekstrin domains in vitro
-
?
additional information
?
-
-
substrate specificity, mammalian isozyme II possesses transacetylase activity as well
-
?
additional information
?
-
-
enzyme level in vivo is linked to the LDL-level, physiological functions of isozymes, overview, the beta-subunit of isozyme Ib interacts with tubulin and with microtubule-associated proteins
-
?
additional information
?
-
-
HDL-associated plasma isozyme may be involved in the protective role of HDL in artherosclerosis, plasma enzyme is associated to LDL, preferably LDL-5 and VLDL-1 particles, the enzyme contributes to the oxidation of LDL in increasing the content of lysoPAF, inflammatory and vascular diseases alter the plasma isozyme activity, enzyme is involved in several diseases and deficiencies, overview
-
?
additional information
?
-
-
individuals with primary heterozygous or homozygous familial hypercholesterolemia show enhanced plasma enzyme activity compared to normolipidemic controls, thereby the level of plasma LDL, to which the enzyme is associated, is increased as well as the enzyme activity per LDL particle, level and activity of HDL-associated enzyme is unaltered
-
?
additional information
?
-
-
isozyme II activity is 3fold increased insubjects suffering meningitis
-
?
additional information
?
-
-
plasma isozyme is bound to LDL and HDL particles
-
?
additional information
?
-
-
the enzyme is associated mainly with LDL containing apolipoprotein B, a small portion is also associated with HDL particles which play a predominantly antiatherogenic role
-
?
additional information
?
-
-
the enzyme is associated to low-density lipoprotein LDL particles, both enzyme activities, acetylhydrolase and transacetylase, decrease during LDL oxidation
-
?
additional information
?
-
-
the plasma isozyme is associated with LDL, 80%, and HDL, 15-20%, and VLDL, below 5%, particles, where it seems to be independently regulated and to have distinct roles in artherosclerosis, LDL-associated enzyme has a protective role in artheriosclerosis, regulation of lipoprotein-associated enzyme in vivo, overview
-
?
additional information
?
-
-
enzyme activity is suggested to be an important marker for atherogenicity
-
-
?
additional information
?
-
-
blood plasma PAF-AH plays an antiinflammatory role in the pathogenesis of human diseases such as asthma and septic shock
-
-
?
additional information
?
-
-
PAF acetylhydrolases play key roles in the hydrolysis of F2-isoprostanes esterified on phospholipids in vivo
-
-
?
additional information
?
-
PAF-AH II exerts strong neuroprotective effects against ischemic injury
-
-
?
additional information
?
-
-
PAF-AH II exerts strong neuroprotective effects against ischemic injury
-
-
?
additional information
?
-
-
platelet activating factor acetylhydrolase (paf-ah), a potent regulator of platelet activating factor activity, plays an important role in various physiological and pathophysiological functions including development, reproduction, inflammation, hemostasis, and apoptosis
-
-
?
additional information
?
-
platelet activating factor acetylhydrolase (paf-ah), a potent regulator of platelet activating factor activity, plays an important role in various physiological and pathophysiological functions including development, reproduction, inflammation, hemostasis, and apoptosis
-
-
?
additional information
?
-
-
platelet-activating factor acetylhydrolase serves as a decapacitation factor
-
-
?
additional information
?
-
-
PAF-AH does not deacylate 1,2-dipalmitoyl-phosphatidylcholine (DPPC) or lipoprotein
-
-
?
additional information
?
-
-
catalyzes the removal of the acyl group at the sn-2 position of platelet-activating factor and truncated phospholipids
-
-
?
additional information
?
-
-
Lp-PLA2 generates oxidized nonesterified fatty acids and lysophosphatidylcholine, both of which have demonstrated proinflammatory and proapoptotic activities
-
-
?
additional information
?
-
-
Lp-PLA2 generates the proinflammatory mediators lysophosphatidylcholine and oxidized fatty acid
-
-
?
additional information
?
-
-
Lp-PLA2 hydrolyzes oxidized phospholipids into oxidized fatty acids and lysophosphatidylcholine products
-
-
?
additional information
?
-
-
the type 1 PAF acetylhydrolase is one of three mammalian family members of the group 7 phospholipase A2 family, a family that is unique in that all members require a short sn-2 ester such as the acetyl ester of PAF
-
-
?
additional information
?
-
-
recombinant PAFAH1B2, but not its family member plasma PAF acetylhydrolase, hydrolyzes acetylsalicylic acid to acetate and salicylate, activity of EC 3.1.1.55
-
-
?
additional information
?
-
-
group VII plasma and type II enzymes also hydrolyze unmodified sn-2 fatty acyl residues up to 5 or 6 carbon atoms long, but this length restriction is greatly relaxed when the omega-end of the sn-2 residue contains oxidized functions
-
-
?
additional information
?
-
-
enzyme of melanoma cell line inhibits neoangiogenesis and endothelial tubulogenesis in vitro, overview
-
?
additional information
?
-
-
substrate specificity of the enzyme forms and isoenzyme types
-
?
additional information
?
-
-
substrate specificity, mammalian isozyme II possesses transacetylase activity as well
-
?
additional information
?
-
-
physiological functions of isozymes, overview
-
?
additional information
?
-
PAF-AH (II) is involved in the metabolism of esterified 8-isoprostaglandin F2alpha and protects tissue from oxidative stress-induced injury
-
-
?
additional information
?
-
-
PAF-AH (II) is involved in the metabolism of esterified 8-isoprostaglandin F2alpha and protects tissue from oxidative stress-induced injury
-
-
?
additional information
?
-
-
the PAF-AH (I) catalytic subunits induces centrosomal amplification and microtubule disorganization by disturbing intracellular localization of LIS1 (a causative gene product for type I lissencephaly)
-
-
?
additional information
?
-
-
PAF-AH catalyzes the hydrolysis of the acetyl group esterifying the sn-2 position of PAF, thereby abolishing its biological activity
-
-
?
additional information
?
-
-
PAF-AH catalyzes the hydrolysis of the acetyl group esterifying the sn-2 position of PAF, thereby abolishing its biological activity
-
-
?
additional information
?
-
-
substrate specificity of the enzyme forms and isoenzyme types
-
?
additional information
?
-
-
physiological functions of isozymes, overview
-
?
additional information
?
-
-
substrate specificity, overview
-
?
additional information
?
-
-
substrate specificity of the enzyme forms and isoenzyme types
-
?
additional information
?
-
-
substrate specificity, mammalian isozyme II possesses transacetylase activity as well
-
?
additional information
?
-
-
physiological functions of isozymes, overview
-
?
additional information
?
-
recombinant platelet-activating factor-acetylhydrolase attenuates paracetamol-induced liver oxidative stress, injury, and regeneration
-
-
?
additional information
?
-
-
recombinant platelet-activating factor-acetylhydrolase attenuates paracetamol-induced liver oxidative stress, injury, and regeneration
-
-
?
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1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
-
-
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecanoyl-sn-glycero-3-phosphocholine
1-hexadecyl-sn-glycero-3-phosphocholine + 2-acetyl-1-hexadecanoyl-sn-glycero-3-phosphocholine
-
transacetylation
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine
1-hexadecyl-sn-glycero-3-phosphocholine + 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine
-
the transacetylase activity may acetylate extracellular lyso-PAF into biologically active PAF
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
2-hexadecyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, substrate and enzyme play important roles in inflammation processes
-
?
3-O-hexadecyl-2-acetyl-sn-glycero-1-phosphocholine + H2O
3-O-hexadecyl-sn-glycero-1-phosphocholine + acetate
F2-isoprostane phospholipid + H2O
F2-isoprostane + phospholipid
-
plays key roles in the hydrolysis of F2-isoprostanes esterified on phospholipids in vivo, involved in oxidative stress response
-
-
?
oxidized phospholipids + H2O
?
phospholipid + H2O
?
-
degradation of phospholipids produced by oxidative stress
-
-
?
phospholipids + H2O
?
-
hydrolyzes sn-2-ester bonds of fragmented or oxidized phospholipids, enzyme deficiency results in an increased risk of stroke, coronary artery disease, atherosclerotic occlusive disease, and abdominal aortic aneurysm
-
-
?
platelet activating factor + H2O
acetate + deacetylated platelet activating factor
platelet-activating factor + H2O
?
platelet-activating factor + H2O
lyso-platelet-activating factor + acetate
-
-
-
-
?
additional information
?
-
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
-
-
-
?
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
-
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor, protection against toxic effects of platelet-activating factor
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
platelet-activating factor
lyso-platelet-activating factor
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
regulation of platelet-activating factor, essential for epithelial morphogenesis
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
inactivation of platelet-activating factor, up-regulation of enzyme by pioglitazone reduces cell elongation
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor, anti-inflammatory enzyme
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor, enzyme could play an important role in the development or down regulation of inflammation in acute respiratory distress syndrome
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor, important role in inflammation and in atherosclerotic processes related to the metabolic syndrome
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
platelet-activating factor
lyso-platelet-activating factor
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
regulation of platelet-activating factor, anti apoptotic protein
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
enzyme from red blood cells is not involved in the degradation of platelet-activating factor accumulated in blood
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
-
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
the substrate is a potent inflammatory mediator
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
inactivation of the substrate which represents a wide variety of bioactivities, including hypotension, platelat activation, bronchoconstriction
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
-
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
i.e. PAF
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
the enzyme abolishes the inflammatory effects of the substrate on leukocytes and the vasculature
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
the substrate mediates a wide spectrum of actions, including hypotension, changes in smooth muscle tone, vascular permeability, signalling in inflammation and allergy. The intracelluar form of the enzyme regulates the accumulation of the substrate, e.g. in macrophages and platelets
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
the substrate is a potent lipid mediator, involved in pathological responses, particularly in inflammation and allergy. Its level is regulated by hydrolysis
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
i.e. PAF
-
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
biological inactivation of the platelet-activation factor by hydrolysis of the acetyl group at sn-2 position which is essential for activity of PAF
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
-
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibits the initiation of inflammation processes
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
-
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
enzyme plays an important role in inflammatory diseases and artherosclerosis, and is involved in non-insulin dependent diabetes mellitus, the level of free, LDL- and/or HDL-associated enzyme is important, overview
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, a mediator of several vascular and inflammatory diseases
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, hydrolysis of sn-2 ester bond of platelet-activating factor PAF and related inflammatory phospholipids, attenuation of their bioactivity, the beta-subunit of intracellular isozyme type II is encoded by gene LIS1, mutations of which cause Miller-Dieker lissencephaly
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, the enzyme converts the proinflammatory autocoid platelet-activating factor PAF into biologically inactive lyso-PAF, by the removal of the sn-2 acetyl group
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
the enzyme is essential for metabolism of platelet-activation factor and phospholipids, i.e. bioactive lipids that are involved in the pathophysiology of arherosclerosis
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, a mediator of several vascular and inflammatory diseases
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibitsthe initiation of inflammation processes
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibitsthe initiation of inflammation processes
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, hyperoxemic rats show reduced enzyme activity in bronchoalveolar lavage and slightly increased levels in the plasma
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibitsthe initiation of inflammation processes
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, the enzyme hydrolyzes and inactivates platelet-activating factor PAF and PAF-like phospholipids which are implicated in numerous pathological situations including bacterial endotoxemia and injury-induced oxidative damage
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, biological inactivation by deacetylation
-
?
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
-
-
?
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
-
-
?
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
-
-
?
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
-
-
?
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
-
-
?
3-O-hexadecyl-2-acetyl-sn-glycero-1-phosphocholine + H2O
3-O-hexadecyl-sn-glycero-1-phosphocholine + acetate
-
-
-
-
?
3-O-hexadecyl-2-acetyl-sn-glycero-1-phosphocholine + H2O
3-O-hexadecyl-sn-glycero-1-phosphocholine + acetate
-
-
-
-
?
oxidized phospholipids + H2O
?
-
protection against toxic effects of oxidized phospholipids
-
-
?
oxidized phospholipids + H2O
?
-
-
-
-
?
oxidized phospholipids + H2O
?
-
degradation of oxidized phospholipids formed during the oxidative modification of low-density lipoprotein
-
-
?
platelet activating factor + H2O
acetate + deacetylated platelet activating factor
-
erythrocyte and plasma PAF acetylhydrolases
-
-
?
platelet activating factor + H2O
acetate + deacetylated platelet activating factor
-
-
-
-
?
platelet-activating factor + H2O
?
-
-
-
-
?
platelet-activating factor + H2O
?
-
-
-
?
platelet-activating factor + H2O
?
-
-
-
-
?
additional information
?
-
enzyme plays a critical role in control of neuronal migration during cortex development
-
?
additional information
?
-
-
enzyme plays a critical role in control of neuronal migration during cortex development
-
?
additional information
?
-
-
one of the physiological roles of isozyme II is to diversify the biological function of PAF by producing different lipid mediators such as analogues of PAF and C2-ceramide, mutations of the gene encoding the enzyme lead to severe diseases, e.g. brain impairment, mental retardation, or lymphoma development
-
?
additional information
?
-
-
hydrolyzes also propionyl and butyloyl groups from phosphoglycerides, and truncated acyl chains derived from oxidative cleavage of long-chain polyunsaturated fatty acyl groups, suggesting that they have a role in scavenging selectively oxidized phospholipid species without acting on structural membrane phospholipids
-
-
?
additional information
?
-
hydrolyzes also propionyl and butyloyl groups from phosphoglycerides, and truncated acyl chains derived from oxidative cleavage of long-chain polyunsaturated fatty acyl groups, suggesting that they have a role in scavenging selectively oxidized phospholipid species without acting on structural membrane phospholipids
-
-
?
additional information
?
-
-
hydrolyzes also propionyl and butyryl groups from phosphoglycerides, and truncated acyl chains derived from oxidative cleavage of long-chain polyunsaturated fatty acyl groups, suggesting that they have a role in scavenging selectively oxidized phospholipid species without acting on structural membrane phospholipids
-
-
?
additional information
?
-
hydrolyzes also propionyl and butyryl groups from phosphoglycerides, and truncated acyl chains derived from oxidative cleavage of long-chain polyunsaturated fatty acyl groups, suggesting that they have a role in scavenging selectively oxidized phospholipid species without acting on structural membrane phospholipids
-
-
?
additional information
?
-
-
physiological functions of isozymes, overview
-
?
additional information
?
-
-
substrate specificity, mammalian isozyme II possesses transacetylase activity as well
-
?
additional information
?
-
-
enzyme level in vivo is linked to the LDL-level, physiological functions of isozymes, overview, the beta-subunit of isozyme Ib interacts with tubulin and with microtubule-associated proteins
-
?
additional information
?
-
-
HDL-associated plasma isozyme may be involved in the protective role of HDL in artherosclerosis, plasma enzyme is associated to LDL, preferably LDL-5 and VLDL-1 particles, the enzyme contributes to the oxidation of LDL in increasing the content of lysoPAF, inflammatory and vascular diseases alter the plasma isozyme activity, enzyme is involved in several diseases and deficiencies, overview
-
?
additional information
?
-
-
individuals with primary heterozygous or homozygous familial hypercholesterolemia show enhanced plasma enzyme activity compared to normolipidemic controls, thereby the level of plasma LDL, to which the enzyme is associated, is increased as well as the enzyme activity per LDL particle, level and activity of HDL-associated enzyme is unaltered
-
?
additional information
?
-
-
isozyme II activity is 3fold increased insubjects suffering meningitis
-
?
additional information
?
-
-
plasma isozyme is bound to LDL and HDL particles
-
?
additional information
?
-
-
the enzyme is associated mainly with LDL containing apolipoprotein B, a small portion is also associated with HDL particles which play a predominantly antiatherogenic role
-
?
additional information
?
-
-
the enzyme is associated to low-density lipoprotein LDL particles, both enzyme activities, acetylhydrolase and transacetylase, decrease during LDL oxidation
-
?
additional information
?
-
-
the plasma isozyme is associated with LDL, 80%, and HDL, 15-20%, and VLDL, below 5%, particles, where it seems to be independently regulated and to have distinct roles in artherosclerosis, LDL-associated enzyme has a protective role in artheriosclerosis, regulation of lipoprotein-associated enzyme in vivo, overview
-
?
additional information
?
-
-
enzyme activity is suggested to be an important marker for atherogenicity
-
-
?
additional information
?
-
-
blood plasma PAF-AH plays an antiinflammatory role in the pathogenesis of human diseases such as asthma and septic shock
-
-
?
additional information
?
-
-
PAF acetylhydrolases play key roles in the hydrolysis of F2-isoprostanes esterified on phospholipids in vivo
-
-
?
additional information
?
-
PAF-AH II exerts strong neuroprotective effects against ischemic injury
-
-
?
additional information
?
-
-
PAF-AH II exerts strong neuroprotective effects against ischemic injury
-
-
?
additional information
?
-
-
platelet activating factor acetylhydrolase (paf-ah), a potent regulator of platelet activating factor activity, plays an important role in various physiological and pathophysiological functions including development, reproduction, inflammation, hemostasis, and apoptosis
-
-
?
additional information
?
-
platelet activating factor acetylhydrolase (paf-ah), a potent regulator of platelet activating factor activity, plays an important role in various physiological and pathophysiological functions including development, reproduction, inflammation, hemostasis, and apoptosis
-
-
?
additional information
?
-
-
platelet-activating factor acetylhydrolase serves as a decapacitation factor
-
-
?
additional information
?
-
-
the type 1 PAF acetylhydrolase is one of three mammalian family members of the group 7 phospholipase A2 family, a family that is unique in that all members require a short sn-2 ester such as the acetyl ester of PAF
-
-
?
additional information
?
-
-
substrate specificity, mammalian isozyme II possesses transacetylase activity as well
-
?
additional information
?
-
-
physiological functions of isozymes, overview
-
?
additional information
?
-
PAF-AH (II) is involved in the metabolism of esterified 8-isoprostaglandin F2alpha and protects tissue from oxidative stress-induced injury
-
-
?
additional information
?
-
-
PAF-AH (II) is involved in the metabolism of esterified 8-isoprostaglandin F2alpha and protects tissue from oxidative stress-induced injury
-
-
?
additional information
?
-
-
the PAF-AH (I) catalytic subunits induces centrosomal amplification and microtubule disorganization by disturbing intracellular localization of LIS1 (a causative gene product for type I lissencephaly)
-
-
?
additional information
?
-
-
PAF-AH catalyzes the hydrolysis of the acetyl group esterifying the sn-2 position of PAF, thereby abolishing its biological activity
-
-
?
additional information
?
-
-
PAF-AH catalyzes the hydrolysis of the acetyl group esterifying the sn-2 position of PAF, thereby abolishing its biological activity
-
-
?
additional information
?
-
-
physiological functions of isozymes, overview
-
?
additional information
?
-
-
substrate specificity, mammalian isozyme II possesses transacetylase activity as well
-
?
additional information
?
-
-
physiological functions of isozymes, overview
-
?
additional information
?
-
recombinant platelet-activating factor-acetylhydrolase attenuates paracetamol-induced liver oxidative stress, injury, and regeneration
-
-
?
additional information
?
-
-
recombinant platelet-activating factor-acetylhydrolase attenuates paracetamol-induced liver oxidative stress, injury, and regeneration
-
-
?
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Blank, M.L.; Lee, T.; Fitzgerald, V.; Snyder, F.
A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid)
J. Biol. Chem.
256
175-178
1981
Rattus norvegicus
brenda
Stafforini, D.M.; Rollins, E.N.; Prescott, S.M.; McIntyre, T.M.
The platelet-activating factor acetylhydrolase from human erythrocytes. Purification and properties
J. Biol. Chem.
268
3857-3865
1993
Homo sapiens
brenda
Hattori, M.; Inoue, K.
Purification and characterization of bovine brain platelet-activating factor acetylhydrolase
J. Biol. Chem.
268
18748-18753
1993
Bos taurus
brenda
Jarvi, K.; Langlais, J.; Gagnon, C.; Roberts, K.D.
Platelet-activating factor acetylhydrolase in the male reproductive tract: origin and properties
Int. J. Androl.
16
121-127
1993
Homo sapiens
brenda
Tsaoussis, V.; Vakirtzi-Lemonias, C.
The mouse plasma PAF acetylhydrolase: I. Characterization and properties
J. Lipid Mediat. Cell Signal.
9
301-315
1994
Mus musculus
brenda
Karasawa, K.; Yato, M.; Setaka, M.; Nojima, S.
Purification and characterization of platelet-activating factor acetylhydrolase from peritoneal fluid obtained from guinea pigs after endotoxin shock
J. Biochem.
116
374-379
1994
Cavia porcellus
brenda
Yamada, Y.; Stafforini, D.M.; Imaizumi, T.A.; Zimmermann, G.A.; McIntyre, T.M.; Prescott, S.M.
Characterization of the platelet-activating factor acetylhydrolase from human plasma by heterologous expression in Xenopus laevis oocytes
Proc. Natl. Acad. Sci. USA
91
10320-10324
1994
Homo sapiens
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Bos taurus
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Bos taurus (Q29460), Bos taurus
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Homo sapiens
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Bos taurus
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Homo sapiens
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Sus scrofa
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Rattus norvegicus (P83006)
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Homo sapiens
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Homo sapiens
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Homo sapiens
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Homo sapiens
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Type II platelet-activating factor-acetylhydrolase is essential for epithelial morphogenesis in Caenorhabditis elegans
Proc. Natl. Acad. Sci. USA
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Caenorhabditis elegans, Caenorhabditis elegans (Q22943)
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Lipoprotein-associated PAF-acetylhydrolase activity in subjects with the metabolic syndrome
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Homo sapiens
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Quistad, G.B.; Fisher, K.J.; Owen, S.C.; Klintenberg, R.; Casida, J.E.
Platelet-activating factor acetylhydrolase: selective inhibition by potent n-alkyl methylphosphonofluoridates
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Homo sapiens, Mus musculus
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Mitsios, J.V.; Vini, M.P.; Stengel, D.; Ninio, E.; Tselepis, A.D.
Human platelets secrete the plasma type of platelet-activating factor acetylhydrolase primarily associated with microparticles
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Homo sapiens
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Karabina, S.; Ninio, E.
Plasma PAF-acetylhydrolase: An unfulfilled promise?
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Homo sapiens
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Clinical aspects of plasma platelet-activating factor-acetylhydrolase
Biochim. Biophys. Acta
1761
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Homo sapiens
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Purification and characterization of 45 kDa PAF acetylhydrolase from bovine colostrum
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Bos taurus (Q29460 and P68401), Bos taurus
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Platelet-activating factor-acetylhydrolase can monodeacylate and inactivate lipoteichoic acid
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Homo sapiens
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Grypioti, A.D.; Mykoniatis, M.; Demopoulos, C.A.; Kostopanagiotou, G.
Recombinant platelet-activating factor-acetylhydrolase attenuates paracetamol-induced liver oxidative stress, injury, and regeneration
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Rattus norvegicus (O35264 and O35263), Rattus norvegicus
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Molecular basis for susceptibility of plasma platelet-activating factor acetylhydrolase to oxidative inactivation
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Homo sapiens, Mus musculus (A0JNU3 and Q61206 and Q61205)
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Zhu, J.; Massey, J.B.; Mitchell-Leef, D.; Elsner, C.W.; Kort, H.I.; Roudebush, W.E.
Platelet-activating factor acetylhydrolase activity affects sperm motility and serves as a decapacitation factor
Fertil. Steril.
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Homo sapiens
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Yamaguchi, N.; Koizumi, H.; Aoki, J.; Natori, Y.; Nishikawa, K.; Natori, Y.; Takanezawa, Y.; Arai, H.
Type I platelet-activating factor acetylhydrolase catalytic subunits over-expression induces pleiomorphic nuclei and centrosome amplification
Genes Cells
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Mus musculus
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Kono, N.; Inoue, T.; Yoshida, Y.; Sato, H.; Matsusue, T.; Itabe, H.; Niki, E.; Aoki, J.; Arai, H.
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Mus musculus (Q8VDG7), Mus musculus
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Davis, B.; Koster, G.; Douet, L.J.; Scigelova, M.; Woffendin, G.; Ward, J.M.; Smith, A.; Humphres, J.; Burnand, K.G.; Macphee, C.H.; Postle, A.D.
Electrospray ionization mass spectrometry identifies substrates and products of lipoprotein-associated phospholipase A2 in oxidized human low density lipoprotein
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Homo sapiens
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Chen, J.; Yang, L.; Foulks, J.M.; Weyrich, A.S.; Marathe, G.K.; McIntyre, T.M.
Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis
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Homo sapiens
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Caini, P.; Guerra, C.T.; Giannini, C.; Giannelli, F.; Gragnani, L.; Petrarca, A.; Solazzo, V.; Monti, M.; Laffi, G.; Zignego, A.L.
Modifications of plasma platelet-activating factor (PAF)-acetylhydrolase/PAF system activity in patients with chronic hepatitis C virus infection
J. Viral Hepat.
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Homo sapiens
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Scott, B.T.; Olson, N.; Long, G.L.; Bovill, E.G.
Novel isoforms of intracellular platelet activating factor acetylhydrolase (PAFAH1b2) in human testis; encoded by alternatively spliced mRNAs
Prostaglandins Other Lipid Mediat.
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2007
Homo sapiens, Homo sapiens (P68402)
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Umemura, K.; Kato, I.; Hirashima, Y.; Ishii, Y.; Inoue, T.; Aoki, J.; Kono, N.; Oya, T.; Hayashi, N.; Hamada, H.; Endo, S.; Oda, M.; Arai, H.; Kinouchi, H.; Hiraga, K.
Neuroprotective role of transgenic PAF-acetylhydrolase II in mouse models of focal cerebral ischemia
Stroke
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Homo sapiens (Q99487), Homo sapiens
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Lerman, A.; McConnell, J.P.
Lipoprotein-associated phospholipase A2: a risk marker or a risk factor?
Am. J. Cardiol.
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Homo sapiens
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Anderson, J.L.
Lipoprotein-associated phospholipase A2: an independent predictor of coronary artery disease events in primary and secondary prevention
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Homo sapiens
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Turk, R.; Juretic, D.; Geres, D.; Bacic, G.; Milesevic, M.; Flegar-Mestric, Z.; Turk, N.; Svetina, A.
Bovine platelet-activating factor acetylhydrolase (PAF-AH) activity related to fertility
Anim. Reprod. Sci.
105
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2008
Bos taurus
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Schmidt, E.B.; Koenig, W.; Khuseyinova, N.; Christensen, J.H.
Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids
Atherosclerosis
196
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2008
Homo sapiens
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Rosenson, R.S.; Vracar-Grabar, M.; Helenowski, I.
Lipoprotein associated phospholipase A2 inhibition reduces generation of oxidized fatty acids: Lp-LPA2 reduces oxidized fatty acids
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22
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Homo sapiens
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Stafforini, D.M.
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Homo sapiens
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Brilakis, E.S.; Khera, A.; Saeed, B.; Banerjee, S.; McGuire, D.K.; Murphy, S.A.; de Lemos, J.A.
Association of lipoprotein-associated phospholipase A2 mass and activity with coronary and aortic atherosclerosis: findings from the Dallas Heart Study
Clin. Chem.
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Homo sapiens
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Lavi, S.; Herrmann, J.; Lavi, R.; McConnell, J.P.; Lerman, L.O.; Lerman, A.
Role of lipoprotein-associated phospholipase A2 in atherosclerosis
Curr. Atheroscler. Rep.
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2008
Homo sapiens
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Foulks, J.M.; Weyrich, A.S.; Zimmerman, G.A.; McIntyre, T.M.
A yeast PAF acetylhydrolase ortholog suppresses oxidative death
Free Radic. Biol. Med.
45
434-442
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Schizosaccharomyces pombe
brenda
Gardner, A.A.; Reichert, E.C.; Topham, M.K.; Stafforini, D.M.
Identification of a domain that mediates association of platelet-activating factor acetylhydrolase with high density lipoprotein
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283
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Homo sapiens, Mus musculus
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Samanta, U.; Bahnson, B.J.
Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis
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283
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Homo sapiens (Q13093), Homo sapiens
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Figueiredo, M.B.; Genta, F.A.; Garcia, E.S.; Azambuja, P.
Lipid mediators and vector infection: Trypanosoma rangeli inhibits Rhodnius prolixus hemocyte phagocytosis by modulation of phospholipase A2 and PAF-acetylhydrolase activities
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54
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Rhodnius prolixus
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Tsoukatos, D.C.; Brocheriou, I.; Moussis, V.; Panopoulou, C.P.; Christofidou, E.D.; Koussissis, S.; Sismanidis, S.; Ninio, E.; Siminelakis, S.
Platelet-activating factor acetylhydrolase and transacetylase activities in human aorta and mammary artery
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Homo sapiens
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McIntyre, T.M.; Prescott, S.M.; Stafforini, D.M.
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Mammalia
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Gomes, M.d.e..B.; Cobas, R.A.; Nunes, E.; Nery, M.; Castro-Faria-Neto, H.C.; Tibirica, E.
Serum platelet-activating factor acetylhydrolase activity: a novel potential inflammatory marker in type 1 diabetes
Prostaglandins Other Lipid Mediat.
87
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Homo sapiens
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Samanta, U.; Wilder, C.; Bahnson, B.J.
Crystallization and preliminary X-ray crystallographic analysis of human plasma platelet activating factor acetylhydrolase
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Homo sapiens
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Turk, R.; Habus, J.; Flegar-Mestric, Z.; Svetina, A.; Mojcec, V.; Perkov, S.; Belis, M.; Staresina, V.; Turk, N.
Serum platelet-activating factor acetylhydrolase and paraoxonase-1 activity in horses infected with Leptospira spp
Acta Trop.
118
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2011
Equus caballus
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Gardner, A.A.; Reichert, E.C.; Alexander, T.S.; Topham, M.K.; Stafforini, D.M.
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Homo sapiens, Mus musculus
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Pande, A.H.; Tillu, V.A.
Membrane lipid composition differentially modulates the function of human plasma platelet activating factor-acetylhydrolase
Biochim. Biophys. Acta
1811
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2011
Homo sapiens
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Liu, J.; Chen, R.; Marathe, G.K.; Febbraio, M.; Zou, W.; McIntyre, T.M.
Circulating platelet-activating factor is primarily cleared by transport, not intravascular hydrolysis by lipoprotein-associated phospholipase A2/PAF acetylhydrolase
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Mus musculus, Mus musculus BL6
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Howard, K.M.; Abdel-Al, M.; Ditmyer, M.; Patel, N.
Lipopolysaccharide and platelet-activating factor stimulate expression of platelet-activating factor acetylhydrolase via distinct signaling pathways
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2011
Homo sapiens
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Zhou, G.; Marathe, G.K.; Willard, B.; McIntyre, T.M.
Intracellular erythrocyte PAF acetylhydrolase 1 inactivates aspirin in blood
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Homo sapiens
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Corte-Real, R.; Gomes, R.N.; Castro-Faria-Neto, H.C.; Azambuja, P.; Garcia, E.S.
The activity of platelet activating factor-acetyl hydrolase (PAF-AH) in the salivary glands of Rhodnius prolixus
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57
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Rhodnius prolixus
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Wojcicka, G.; Jamroz-Wisniewska, A.; Marciniak, A.; Lowicka, E.; Beltowski, J.
The differentiating effect of glimepiride and glibenclamide on paraoxonase 1 and platelet-activating factor acetylohydrolase activity
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Rattus norvegicus
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Lu, J.; Pierce, M.; Franklin, A.; Jilling, T.; Stafforini, D.M.; Caplan, M.
Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis
Pediatr. Res.
68
225-230
2010
Mus musculus, Mus musculus C57/BL6J
brenda