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IUBMB CommentsSimultaneously dephosphorylates and activates EC 2.7.1.40 pyruvate kinase, that has been inactivated by protein kinase.
The enzyme appears in viruses and cellular organisms
Synonyms
pyruvate kinase phosphatase,
more
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phosphatase, pyruvate kinase
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pyruvate kinase phosphatase
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[pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate
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hydrolysis of phosphoric ester
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[ATP:pyruvate 2-O-phosphotransferase]-phosphate phosphohydrolase
Simultaneously dephosphorylates and activates EC 2.7.1.40 pyruvate kinase, that has been inactivated by protein kinase.
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ADP + H2O
AMP + phosphate
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ATP + H2O
ADP + phosphate
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GTP + H2O
GDP + phosphate
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[pyruvate kinase] phosphate + H2O
pyruvate kinase + phosphate
[pyruvate kinase] phosphate + H2O
pyruvate kinase + phosphate
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[pyruvate kinase] phosphate + H2O
pyruvate kinase + phosphate
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[pyruvate kinase] phosphate + H2O
pyruvate kinase + phosphate
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[pyruvate kinase] phosphate + H2O
pyruvate kinase + phosphate
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reactivation of pyruvate kinase by dephosphorylation
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[pyruvate kinase] phosphate + H2O
pyruvate kinase + phosphate
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reactivation of pyruvate kinase by dephosphorylation
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Mg2+
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required, Km: 0.0079 mM
Mg2+
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MgCl2, highly dependent on
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Ca2+
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at high concentrations
Mg2+
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at high concentration, IC50: 2.3 mM
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2.3
Mg2+
Busycotypus canaliculatus
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at high concentration, IC50: 2.3 mM
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additional information
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5.5 - 8
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pH 5.5: about 25% of maximal activity, pH 8.0: about 15% of maximal activity
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brenda
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brenda
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brenda
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brenda
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brenda
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A0A7C9AVF4_OPUST
548
0
60109
TrEMBL
Chloroplast (Reliability: 5)
A0A7C9AVU1_OPUST
576
1
63570
TrEMBL
Mitochondrion (Reliability: 5)
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Brooks, S.P.J.; Storey, K.B.
Purification and characterization of a protein phosphatase that dephosphorylates pyruvate kinase in an anoxia tolerant animal
Biochem. Mol. Biol. Int.
38
1223-1234
1996
Busycotypus canaliculatus
brenda
Jett, M.F.; Hue, L.; Hers, H.G.
Pyruvate kinase phosphatase
FEBS Lett.
132
183-186
1981
Rattus norvegicus
brenda
Lopez-Alarcon, L.; Mojena, M.; Monge, L.; Feliu, J.E.
Stimulation of pyruvate kinase phosphatase activity by insulin in isolated rat hepatocytes
Biochem. Biophys. Res. Commun.
134
292-298
1986
Rattus norvegicus
brenda
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