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1-acyl-2-arachidonoylphosphatidylinositol + H2O
?
-
-
-
-
?
1-acyl-2-linoleoylphosphatidylinositol + H2O
?
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
in almost equal amounts with 1D-myo-inositol 1,2-cyclic phosphate
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-triphosphate + diacylglycerol
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
1D-myo-inositol 1,4,5-trisphosphate fluorescent derivative WH-15 + H2O
1D-myo-inositol 1,4,5-trisphosphate + quinomethide + 6-aminoquinoline + ?
-
-
-
-
ir
arachidonoyl-phosphatidylinositol + H2O
1,2-diarachidonoyl-sn-glycerol + 1D-myo-inositol 1-phosphate
-
-
-
-
?
arachidonoylphosphatidylinositol + H2O
myo-inositol 1-phosphate + 1,2-diarachidonoylglycerol
-
-
-
?
butyl-fluorescein myo-inositol phosphate + H2O
?
-
-
-
-
?
diarachidonoylphosphatidylinositol + H2O
1,2-diacylglycerol + 1D-myo-inositol 1-phosphate
-
-
a mixture of 86% myoinositol 1-phosphate and 14% myoinositol 1,2-cyclic phosphate
-
?
dibutyrylphosphatidylinositol + H2O
?
-
-
-
?
glycosylphosphatidylinositol + H2O
?
-
catalytic mechanism
-
?
GPI-renal dipeptidase
?
-
-
-
-
?
phosphatidylinositol + H2O
1,2-diacylglycerol + 1D-myo-inositol 1-phosphate
-
-
1D-myo-inositol 1,2-cyclic phosphate is also formed
-
?
phosphatidylinositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
phosphatidylinositol + H2O
1D-myo-inositol 1-phosphate + glycerophosphoinositol + phosphate + ?
-
-
ratio between products decreased with increasing pH, 1D-myo-inositol 1,2-cyclic phosphate is also formed
-
?
phosphatidylinositol + H2O
1D-myo-inositol-1-phosphate + diacylglycerol
-
-
in vitro 1D-myo-inositol-1,2-cyclic phosphate is also formed
-
?
phosphatidylinositol + H2O
?
phosphatidylinositol + H2O
diacylglycerol + 1D-myo-inositol 1-phosphate
phosphatidylinositol + H2O
diacylglycerol + inositol 1,2-(cyclic)-phosphate
-
-
-
?
phosphatidylinositol + H2O
diacylglycerol + myo-inositol 1-phosphate
-
phosphatidylinositol-specific, catalytic mechanism
-
?
phosphatidylinositol + H2O
myo-inositol 1-phosphate + diacylglycerol
phosphatidylinositol 4,5-bisphosphate
inositol 1,4,5-trisphosphate
-
demonstration of the role of PLC in Ca2+-induced inactivation of TRPV6
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
phosphatidylinositol 4,5-bisphosphate + H2O
diacylglycerol + 1D-myo-inositol 1,4,5-triphosphate
-
PLC4 and PLC6 encode catalytically active enzymes that convert phosphatidylinositol into diacylglycerol
-
-
?
phosphatidylinositol 4-phosphate
?
phosphatidylinositol 4-phosphate + H2O
1D-myo-inositol 4,5-bisphosphate + diacylglycerol
phosphatidylinositol 4-phosphate + H2O
?
soybean oil + H2O
?
-
-
-
?
additional information
?
-
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
in almost equal amounts with 1D-myo-inositol 1,2-cyclic phosphate
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-triphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-triphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-triphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
AtPLC2, preferred substrate, N-terminal EF-hand-like domain is required for catalytic activity but not for lipid binding
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
phosphoinositide-specific, PLC delta structure with EF-hand motif and PH domain
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
PLC-beta1
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes
second messengers
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
plays a role in various signal transduction pathways, DsPLC2 plays a role in an early event in the light induction process of C4 photosynthesis
the products act as second messengers in cell signalling
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Drosophila sp. (in: flies)
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Drosophila sp. (in: flies)
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
products are two second messengers
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
domain structure of PLC-epsilon, contains RasGEF and RA domains
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
domain structure of PLCgamma2, roles of the different domains
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
domain structures of PLC-beta, -gamma and -delta isoenzymes
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
phosphoinositide-specific
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
phosphoinositide-specific
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
phosphoinositide-specific, PLC delta structure with EF-hand motif and PH domain
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
key step in the intracellular transduction of a large number of extracellular signals, including neurotransmitters and hormones modulating diverse developmental and functional aspects of the central nervous system
second messengers
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes
second messengers
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
PI-PLC beta1 could have a role in muscle hypertrophy taking place in human muscular dystrophy
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
domain organization of the PLC isoenzymes beta, gamma, delta and epsilon, distinct regulatory domains
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
regulation of PLC isoenzymes, cellular signaling
intracellular messengers
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
products are two second messengers
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
domain structure of PLCdelta1
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
domain structure of PLCzeta
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
PLCbeta1 is involved in nuclear inositol lipid signaling
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
sperm-specific PLCzeta induces intracellular Ca2+ oscillations and subsequent early embryonic development when expressed in mouse eggs, PLCzeta may be the physiological mammalian egg-activating sperm factor
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
PI-PLC beta1 is essential in the IGF-1 mitogenic signaling pathway
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
part of the phosphoinositide signal transduction pathway
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
products are two second messengers
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
domain structures of PLCbeta, -gamma and -delta isoenzymes
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
phosphoinositide-specific
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
phosphoinositide-specific, PLC delta structure with EF-hand motif and PH domain
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
PLC-delta1, structure of the catalytic domain, His-311 and His-356 act as general acid-base catalysts
4- and 5-phosphoryl groups of inositol 1,4,5-trisphosphate interact with the side chains of Lys-32 and Lys-57 and with those of Lys-30, Arg-40 and Lys-57 of PLC-delta1, respectively
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
key enzyme in signal transduction generating the intracellular second messengers DAG and IP3
second messengers
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes
second messengers
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
amino acids Pro500 and His503 are critical for binding of PLC-gamma1 to one of its substrates, 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate in the membrane
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
PLC beta1b
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
PLC-delta1
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
PLC-gamma1
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
interaction analysis, modeling and binding kinetics of substrate and enzyme PH-PLCdelta1, overview. PH-PLCdelta1 binds specifically to 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, breaking up clusters and expelling nonspecifically associated peptide from the surface
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
PLC-delta1, structure of the catalytic domain, His-311 and His-356 act as general acid-base catalysts
4- and 5-phosphoryl groups of inositol 1,4,5-trisphosphate interact with the side chains of Lys-32 and Lys-57 and with those of Lys-30, Arg-40 and Lys-57 of PLC-delta1, respectively
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
preferred substrate
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
preferred substrate
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
preferred substrate
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
saPLC1 employs a unique catalytic mechanism whereby the cleavage of phosphatidylinositol into inositol 1-phosphate occurs via a trans cyclization mechanism involving formation of inositol 1,6-cyclic phosphate as an intermediate
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
phosphoinositide-specific, preferred substrate to phosphatidylinositol, domain structure
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
inositol phosphate/diacylglycerol signaling pathway, TcPI-PLC is lipid modified in vivo, TcPI-PLC is developmentally regulated, its expression is induced during the differentiation of trypomastigotes into amastigotes at an early stage in the transformation process
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
preferred substrate
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
preferred substrate. With 1-phosphatidyl-1D-myo-inositol 4-phosphate, the enzyme displays a more than 3fold higher hydrolyzing activity compared to 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
phosphatidylinositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
enzyme is phosphatidylinositol specific
-
-
?
phosphatidylinositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
in vitro myo-inositol 1,2-cyclic phosphate also formed
-
?
phosphatidylinositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
phosphatidylinositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
1D-myo-inositol 1,2-cyclic-phosphate is also formed
-
?
phosphatidylinositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
in vitro also 1D-myo-inositol 1,2-cyclic phosphate formed
-
?
phosphatidylinositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
in vitro also inositol cyclic monophosphate formed
-
?
phosphatidylinositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
enzyme hydrolyses both membrane-bound and extracted phosphatidylinositol
in vitro myo-inositol 1,2-cyclic phosphate, myo-inositol 1-phosphate, and glycerophosphoinositol in the molar proportions approx. 2:1:1
-
?
phosphatidylinositol + H2O
?
-
-
-
-
?
phosphatidylinositol + H2O
?
-
-
-
-
?
phosphatidylinositol + H2O
?
-
7% of the activity with phosphatidylinositol 4,5-diphosphate
-
-
?
phosphatidylinositol + H2O
?
-
-
-
-
?
phosphatidylinositol + H2O
?
-
at neutral pH and low Ca2+ concentration the membrane bound enzyme hydrolyzes phosphatidylinositol 4,5-diphosphate in preference to phosphatidylinositol
-
-
?
phosphatidylinositol + H2O
?
-
-
-
-
?
phosphatidylinositol + H2O
?
-
no activity
-
-
?
phosphatidylinositol + H2O
?
-
-
-
-
?
phosphatidylinositol + H2O
?
-
-
-
?
phosphatidylinositol + H2O
?
-
phosphatidylinositol 4,5-bisphosphate is a better substrate
-
-
?
phosphatidylinositol + H2O
?
-
PLC-delta1, structure of the catalytic domain
-
?
phosphatidylinositol + H2O
?
-
low molecular weight PLC hydrolyzes both phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate, high molecular PLC shows much greater activity against phosphatidylinositol than phosphatidylinositol 4,5-bisphosphate
-
-
?
phosphatidylinositol + H2O
?
-
PLC-delta1, structure of the catalytic domain
-
?
phosphatidylinositol + H2O
?
-
-
-
-
?
phosphatidylinositol + H2O
?
-
Ca2+ required. At 0.1 mM the enzyme hydrolyzes phosphatidylinositol 4,5-diphosphate at faster rate than phosphatidylinositol, at 0.005 mM Ca2+ it hydrolyzes phosphatidylinositol 4,5-diphosphate exclusively
-
-
?
phosphatidylinositol + H2O
?
-
-
-
-
?
phosphatidylinositol + H2O
?
-
phosphatidylinositol monolayer at an air/water interface
-
-
?
phosphatidylinositol + H2O
?
-
-
-
?
phosphatidylinositol + H2O
diacylglycerol + 1D-myo-inositol 1-phosphate
-
-
the lipoidal product of hydrolysis is diacylglycerol, the water-soluble products are 1D-myo-inositol 1,2-cyclic phosphate and 1D-myo-inositol 1-phosphate in the approximate proportions of 60% and 40%, respectively
-
?
phosphatidylinositol + H2O
diacylglycerol + 1D-myo-inositol 1-phosphate
-
Pi-PLC (membrane) and Pi-PLC (cytosol) are specific for this substrate
-
-
?
phosphatidylinositol + H2O
diacylglycerol + 1D-myo-inositol 1-phosphate
-
enzyme is specific for phosphatidylinositol
-
-
?
phosphatidylinositol + H2O
myo-inositol 1-phosphate + diacylglycerol
60-350times lower specific activity than with phosphatidylinositol 4,5-bisphosphate
-
?
phosphatidylinositol + H2O
myo-inositol 1-phosphate + diacylglycerol
-
-
-
?
phosphatidylinositol + H2O
myo-inositol 1-phosphate + diacylglycerol
phosphatidylinositol 4,5-bisphosphate is preferred to phosphatidylinositol
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
?
-
-
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
?
-
enzyme activities for phosphatidylinositol 4,5-bisphosphate are strongly dependent on the relative levels of calcium and pH in the assay buffer
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
preferentially hydrolyzed
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
enzyme attacks phosphatidylinositol 4,5-diphosphate and phosphatidylinositol 4-phosphate with equal facility
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
membrane-bound enzyme hydrolyzes phosphatidylinositol 4,5-diphosphate in preference to phosphatidylinositol
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
enzyme attacks phosphatidylinositol 4,5-diphosphate and phosphatidylinositol 4-phosphate with equal facility
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
isoenzyme PLC beta1 produces 21% inositol 1:2,4,5 cyclic trisphosphate at pH 5.5 and 7.5% at pH 7.0
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
enzyme attacks phosphatidylinositol 4,5-diphosphate and phosphatidylinositol 4-phosphate with equal facility
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
Ca2+ required. At 0.1 mM the enzyme hydrolyzes phosphatidylinositol 4,5-diphosphate at faster rate than phosphatidylinositol, at 0.005 mM Ca2+ it hydrolyzes phosphatidylinositol 4,5-diphosphate exclusively
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
the enzyme generates two second messengers: D-myo-inositol 1,4,5-trisphosphate and diacylglycerol
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
phosphatidylinositol 4-phosphate
?
-
enzyme attacks phosphatidylinositol 4,5-diphosphate and phosphatidylinositol 4-phosphate with equal facility
-
-
?
phosphatidylinositol 4-phosphate
?
-
phosphatidylinositol 4,5-bisphosphate is a better substrate
-
-
?
phosphatidylinositol 4-phosphate
?
-
20% of the activity with phosphatidylinositol 4,5-diphosphate
-
-
?
phosphatidylinositol 4-phosphate
?
-
enzyme attacks phosphatidylinositol 4,5-diphosphate and phosphatidylinositol 4-phosphate with equal facility
-
-
?
phosphatidylinositol 4-phosphate
?
-
-
-
-
?
phosphatidylinositol 4-phosphate
?
-
enzyme attacks phosphatidylinositol 4,5-diphosphate and phosphatidylinositol 4-phosphate with equal facility
-
-
?
phosphatidylinositol 4-phosphate
?
-
-
-
-
?
phosphatidylinositol 4-phosphate + H2O
1D-myo-inositol 4,5-bisphosphate + diacylglycerol
-
-
-
?
phosphatidylinositol 4-phosphate + H2O
1D-myo-inositol 4,5-bisphosphate + diacylglycerol
-
-
-
-
?
phosphatidylinositol 4-phosphate + H2O
?
-
-
-
-
?
phosphatidylinositol 4-phosphate + H2O
?
-
PLC-delta1, structure of the catalytic domain
-
?
phosphatidylinositol 4-phosphate + H2O
?
-
PLC-delta1, structure of the catalytic domain
-
?
additional information
?
-
-
no detectable activity against phosphatidylcholine or phosphatidylethanolamine
-
-
?
additional information
?
-
-
AtPLC1S is involved in stress responses, AtPLC2 not
-
?
additional information
?
-
AtPLC2 is constitutively expressed
-
?
additional information
?
-
-
AtPLC2 is constitutively expressed
-
?
additional information
?
-
-
PI-PLC has a high affinity for the glycosylphosphatidylinositol anchor of GPI-anchored proteins, e.g. 5-nucleotidase and alkaline phosphatase, and catalyzes cleavage in vitro to release a soluble protein and diacylglycerol, which remains in the membrane, enzyme structure
-
?
additional information
?
-
-
PI-PLC has a high affinity for the glycosylphosphatidylinositol anchor of GPI-anchored proteins, e.g. 5-nucleotidase and alkaline phosphatase, and catalyzes cleavage in vitro to release a soluble protein and diacylglycerol, which remains in the membrane
-
?
additional information
?
-
-
enzyme is phosphatidylinositol-specific and does not act on phosphatidylethanolamine and phosphatidylcholine
-
-
?
additional information
?
-
-
phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine are no substrates
-
-
?
additional information
?
-
-
PLC eta enzyme influences intracellular Ca 2+ dynamics and protein kinase C activation in the brain and neuroendocrine systems as putative mediation of G-protein-coupled receptor regulationlikely mediates G-protein-coupled receptor signalling pathways
-
-
?
additional information
?
-
-
PI-PLC has a high affinity for the glycosylphosphatidylinositol anchor of GPI-anchored proteins, e.g. 5-nucleotidase and alkaline phosphatase, and catalyzes cleavage in vitro to release a soluble protein and diacylglycerol, which remains in the membrane
-
?
additional information
?
-
-
Isc1 only exerts IPC-PLC activity
-
-
?
additional information
?
-
-
Isc1 only exerts IPC-PLC activity
-
-
?
additional information
?
-
Drosophila sp. (in: flies)
-
PLC plays a key role in photoreceptor response
-
?
additional information
?
-
Drosophila sp. (in: flies)
-
phospholipase C is a key factor determining the photoreceptor sensitivity
-
-
?
additional information
?
-
-
the enzymes acting against [3H] inositol-phosphatidylinositol (PtdIns) and [3H] inositolphosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P2] in the cat carotid bodies (CB) are investigated using labelled phospholipids as a source of the substrate. Analysis of water soluble inositol metabolites indicates that PtdIns is degraded exclusively by the enzyme since the inositolmonophosphate (IP1) is detected as a single product. In case of PtdIns(4,5)P2 hydrolysis by carotid bodies (CB) enzymes there are all 3 inositol phosphates: IP3, IP2, IP1
-
-
?
additional information
?
-
-
phosphatidylinositol-phospholipase C plays a critical role, most likely through activation of protein kinase C pathway, in TLR4 mediated immune responses of avian macrophage cells to lipopolysaccharides
-
-
?
additional information
?
-
-
not: phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl serine
-
?
additional information
?
-
-
plays a critical role in signal transduction in the receptor-activated human platelets
-
-
?
additional information
?
-
-
cellular signaling, regulation of PLC activity
-
?
additional information
?
-
PLCgamma isoforms are regulated through activation of tyrosine kinase-linked receptors, importance of PLCgamma2 in B-cell signal transduction
-
?
additional information
?
-
-
PLCgamma isoforms are regulated through activation of tyrosine kinase-linked receptors, importance of PLCgamma2 in B-cell signal transduction
-
?
additional information
?
-
-
PLCgamma2 regulation, role in B-cell signalling
-
?
additional information
?
-
-
Gi-coupled receptors can inhibit PLC-epsilon, most likely by suppressing formation of cyclic AMP required for Epac-mediated Rap2B activation
-
-
?
additional information
?
-
-
interaction of phospholipase C-beta1 with cell polarity Par proteins may serve as a nexus to transduce extracellular signals to transcriptional reguation through G-protein-mediated signaling pathway in cell polarity and cell asymmetric division
-
-
?
additional information
?
-
-
involvement of phospholipase C signaling in melanoma cell-induced endothelial junction disassembly
-
-
?
additional information
?
-
-
PLC-eta enzymes may function in the membrane-mediated signaling cascade through intracellular Ca2+ and protein kinase C pathways
-
-
?
additional information
?
-
PLC-eta may perform fundamental roles in the brain
-
-
?
additional information
?
-
-
PLC-eta may perform fundamental roles in the brain
-
-
?
additional information
?
-
-
regulatory mechanisms controlling expression of PLCepsilon, broadened by diversity introduced by splice variants, could play important role in PLCepsilon regulation in normal and tumor cells
-
-
?
additional information
?
-
regulatory mechanisms controlling expression of PLCepsilon, broadened by diversity introduced by splice variants, could play important role in PLCepsilon regulation in normal and tumor cells
-
-
?
additional information
?
-
-
wild-type Rac GTPase with guanosine 5'-(3-O-thio)triphosphate causes a marked stimulation of PLCgamma2 but has no effect on the activity of PLCgamma1. The mechanism of PLCgamma2 activation by Rac GTPase involves neither protein phosphorylation nor PI3K-mediated generation of phosphatidylinositol 3,4,5-trisphosphate
-
-
?
additional information
?
-
phospholipase C beta3 is a key component in the Gbetagamma/PKCeta/PKD-mediated regulation of trans-Golgi network to plasma membrane transport
-
-
?
additional information
?
-
-
PLC eta enzyme influences intracellular Ca 2+ dynamics and protein kinase C activation in the brain and neuroendocrine systems as putative mediation of G-protein-coupled receptor regulation likely mediates G-protein-coupled receptor signalling pathways
-
-
?
additional information
?
-
PLC-beta2 may improve some malignant characteristics of tumor cells, like motility and invasion capability, but it fails to induce tumorigenesis in nontransformed breast-derived cells
-
-
?
additional information
?
-
-
PLC-beta2 may improve some malignant characteristics of tumor cells, like motility and invasion capability, but it fails to induce tumorigenesis in nontransformed breast-derived cells
-
-
?
additional information
?
-
-
suppression of Pi-PLC promotes apoptosis of vascular endothelial cells by inhibiting phosphorylation of Akt, elevating P53 expression, and affecting the cell cycle distribution. phosphatidyl-specific phospholipase C and phosphatidylcholine-specific phospholipase C might control the apoptosis by jointly regulating akt phosphorylation, P53 expression and affecting cell cycle in vascular endothelial cells
-
-
?
additional information
?
-
-
no phospholipase A2 activity is found in the purified enzymes
-
-
?
additional information
?
-
-
PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho
-
-
?
additional information
?
-
PI-PLC activity might be regulated by a heterotrimeric G protein
-
-
?
additional information
?
-
PI-PLC activity might be regulated by a heterotrimeric G protein
-
-
?
additional information
?
-
water-soluble synthetic short-chain phosphatidylinositol and inositol 1,2-(cyclic)-phosphate along with PI/detergent mixed micelles and PI/PC vesicles are used as substrates
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-
?
additional information
?
-
-
water-soluble synthetic short-chain phosphatidylinositol and inositol 1,2-(cyclic)-phosphate along with PI/detergent mixed micelles and PI/PC vesicles are used as substrates
-
-
?
additional information
?
-
-
suPLCbeta is activated by G protein betagamma subunits
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-
?
additional information
?
-
-
activation of PLCgamma by GTP during initial stages of formation of nuclear envelope provides a mechanism for temporal control of assembly of nuclear envelope
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?
additional information
?
-
-
the activation of the gamma1 isoenzyme is a biologically important event in zona pellucida-stimulated inositol phospholipid metabolism with a potential role in signal transduction leading to acrosomal exocytosis
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?
additional information
?
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PLC delta1 is required for skin stem cell lineage commitment
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?
additional information
?
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PLC-beta1 is nessecary for the development and/or maintenance of brain inhibitory pathways, the retinal variants of PLC-beta4 function in signal processing within the retina, PLC-beta3 plays a role in the early development
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?
additional information
?
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phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy
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?
additional information
?
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-
PLC-eta enzymes may function in the membrane-mediated signaling cascade through intracellular Ca2+ and protein kinase C pathways
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?
additional information
?
-
PLC-eta may perform fundamental roles in the brain
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?
additional information
?
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PLC-eta may perform fundamental roles in the brain
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?
additional information
?
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PLCgamma2 is crucial for development of the NL cell receptor repertoire and signaling of activating NK cell receptors, mediating optimal NL cell function in vivo
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?
additional information
?
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-
recombinant PLCzeta protein induces Ca2+ oscillations in mouse eggs
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?
additional information
?
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recombinant PLCzeta protein induces Ca2+ oscillations in mouse eggs
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?
additional information
?
-
recombinant PLCzeta protein induces Ca2+ oscillations in mouse eggs
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?
additional information
?
-
-
signaling of myelin phagocytosis mediated by complement-receptor-3 alone and by complement-receptor-3 combined with scavenger-receptor-AI/II involves phosphatidylinositol 3-kinase, phosphoinositide-specific phospholipase-Cgamma and protein kinase-C, the cascade phosphatidylinositol 3-kinase -> phosphoinositide-specific phospholipase-Cgamma -> protein kinase-C, and wide range modulation by protein kinase-C
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?
additional information
?
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the neuron-specific enzyme may be important for the formation and/or maintenance of the neuronal network in the postnatal brain
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?
additional information
?
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absolute requirement for PLC-gamma1 in villin-induced cell migration
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?
additional information
?
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inhibition of phosphatidylinositol 3-kinase may go through phosphoinositide-specific phospholipase C pathway leading to increase of expression of the inducible nitric oxide synthase, indicating that phosphatidylinositol 3-kinase and phosphoinositide-specific phospholipase C may counteract to regulate the metabolism of phosphatidylinositol (4,5)-bisphosphate depending on cell types or their conditions
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-
?
additional information
?
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overview: role of nuclear PI-PLCbeta1 in cell proliferation and differentiation
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?
additional information
?
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PLCepsilon is required for thrombin- but not lysophosphatidic acid-induced sustained ERK activation and DNA synthesis, providing a novel mechanism for G protein-coupled receptor and Rho signaling to cell proliferation. PLCepsilon has a role as a guanine nucleotide exchange factor for Rap1
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?
additional information
?
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PLCgamma2 is essential for RANK (Receptor activator of NF-kB) signaling, and its deficiency leads to defective lymph node organogenesis and osteoclast differentiation
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?
additional information
?
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PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho
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?
additional information
?
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-
PLC is involved in activation of the muscarinic receptor-operated cationic current in guinea pig ileal smooth muscle cells
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?
additional information
?
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enzyme is specific for phosphoinositides
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?
additional information
?
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enzyme is not active with phosphatidylcholine and phosphatidylethanolamine as substrate
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?
additional information
?
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the enzyme displays scarcely any activity towards 1-phosphatidyl-1D-myo-inositol or phosphatidylcholine
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?
additional information
?
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significant role for PpPLC1 in cytokinin signalling and gravitropism
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?
additional information
?
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significant role for PpPLC1 in cytokinin signalling and gravitropism
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?
additional information
?
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the enzyme is involved in cytokinin and gravity responses
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?
additional information
?
-
the enzyme is involved in cytokinin and gravity responses
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?
additional information
?
-
PsPLC delta isoform is regulated by light in a tissue specific manner and may be involved in important functions
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?
additional information
?
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-
PsPLC delta isoform is regulated by light in a tissue specific manner and may be involved in important functions
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?
additional information
?
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-
PIP2-PLC is involved in the signal pathway that leads to the acquisition of heat acclimation
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?
additional information
?
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PLCepsilon contains a GTP exchange factor and two C-terminal Ras-binding domains
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?
additional information
?
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-
regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and betagamma subunits is dependent of enzyme subtype and concentration of Mg2+
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?
additional information
?
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the inositol lipid breakdown is controlled by different phosphoinositidase C isoenzymes in various cell compartments
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?
additional information
?
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the activation of the enzyme by m3-mascarinic acid receptor stimulation is mediated via alpha-subunit of the Gq/11 family of G-proteins
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?
additional information
?
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perturbation in a membrane in vivo equivalent to a non-bilayer configuration is sufficient to induce phosphodiesterase-catalyzed phosphatidylinositol 4,5-diphosphate breakdown
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?
additional information
?
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-
transformation-linked and progression-linked signal transduction enzyme
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?
additional information
?
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-
hepatocyte growth factor can activate phosphoinositidase C in rat hepatocytes
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?
additional information
?
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-
cellular signaling
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?
additional information
?
-
PLCepsilon is a Ras effector, directly regulated by Ras and links two critical signaling pathways
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?
additional information
?
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-
activation of phospholipase C is a vital step in the neuronal protective adenosine-induced signal transduction pathway, conferring protection against iodoacetic acid-induced injury in primary rat neuronal cultures
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?
additional information
?
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-
Galpha12712- and Rho-dependent activation of phospholipase C-epsilon by lysophosphatidic acid and thrombin receptors
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?
additional information
?
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interaction of phospholipase C-beta1 with cell polarity Par proteins may serve as a nexus to transduce extracellular signals to transcriptional reguation through G-protein-mediated signaling pathway in cell polarity and cell asymmetric division
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?
additional information
?
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PLC activity is under tight dynamic control of the Ca2+ concentration. In insulin-secreting beta-cells, this mechanism provides a link between Ca2+ influx and release from intracellular stores that may be important in the regulation of insulin secretion
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?
additional information
?
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reduction in phospholipase C may be critical in the pathophysiology of depression and other stress-related disorders
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?
additional information
?
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-
inositide-dependent phospholipase C signaling mimics insulin in skeletal muscle differentiation by affecting specific regions of the cyclin D3 promoter
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?
additional information
?
-
overview: role of nuclear PI-PLCbeta1 in cell proliferation and differentiation
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?
additional information
?
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PLC eta enzyme influences intracellular Ca 2+ dynamics and protein kinase C activation in the brain and neuroendocrine systems as putative mediation of G-protein-coupled receptor regulation likely mediates G-protein-coupled receptor signalling pathways
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?
additional information
?
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PLC activity in vascular smooth muscle cells can be divided into two types based on their calcium and pH requirements, substrate preferences, and molecular weights
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?
additional information
?
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several different assay conditions for both phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate are tested on samples of crude supernatant for their ability to support PLC activity
-
-
?
additional information
?
-
-
the injection fraction shows no activity against phosphatidylcholine
-
-
?
additional information
?
-
-
PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho
-
-
?
additional information
?
-
PLCepsilon contains a GTP exchange factor and two C-terminal Ras-binding domains
-
?
additional information
?
-
PLCepsilon is a Ras effector, directly regulated by Ras and links two critical signaling pathways
-
?
additional information
?
-
-
PI-PLC has a high affinity for the glycosylphosphatidylinositol anchor of GPI-anchored proteins, e.g. 5-nucleotidase and alkaline phosphatase, and catalyzes cleavage in vitro to release a soluble protein and diacylglycerol, which remains in the membrane
-
?
additional information
?
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synthesis of a short-chain (dihexanoyl) analogues of phosphatidylinositol, which exist as monomers at the concentrations used for the kinetic measurements, the cleavage proceeds with the release of the cyclic phosphorothioate
-
-
?
additional information
?
-
-
activation of PLCgamma by GTP during initial stages of formation of nuclear envelope provides a mechanism for temporal control of assembly of nuclear envelope
-
-
?
additional information
?
-
-
PLC-dsu is unlikely to be directly involved in the process of egg activation but may play a role in mediating extracellular signals transmitted via the phosphatidylinositol 3'-kinase pathway
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?
additional information
?
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-
no activity is detectable towards either phosphatidylcholine or phosphatidylethanolamine
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-
?
additional information
?
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-
the enzyme may participate in signal transduction over the plant plasma membrane
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?
additional information
?
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when expressed in plasma membrane, TcPI-PLC is involved in differentiation of trypomastigotes to amastigotes of Trypanosoma cruzi, an essential step for the intracellular replication of these parasites
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-
?
additional information
?
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the Vr-PLC3 protein is specifically activated by drought and salt stress in an abscisic acid-independent manner, with its induction being faster in roots than in leaf tissue
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?
additional information
?
-
the Vr-PLC3 protein is specifically activated by drought and salt stress in an abscisic acid-independent manner, with its induction being faster in roots than in leaf tissue
-
-
?
additional information
?
-
the Vr-PLC3 protein is specifically activated by drought and salt stress in an abscisic acid-independent manner, with its induction being faster in roots than in leaf tissue
-
-
?
additional information
?
-
the Vr-PLC3 protein is specifically activated by drought and salt stress in an abscisic acid-independent manner, with its induction being faster in roots than in leaf tissue
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-triphosphate + diacylglycerol
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
the enzyme generates two second messengers: D-myo-inositol 1,4,5-trisphosphate and diacylglycerol
-
?
additional information
?
-
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-triphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-triphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-triphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes
second messengers
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
plays a role in various signal transduction pathways, DsPLC2 plays a role in an early event in the light induction process of C4 photosynthesis
the products act as second messengers in cell signalling
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
products are two second messengers
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
key step in the intracellular transduction of a large number of extracellular signals, including neurotransmitters and hormones modulating diverse developmental and functional aspects of the central nervous system
second messengers
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes
second messengers
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
PI-PLC beta1 could have a role in muscle hypertrophy taking place in human muscular dystrophy
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
regulation of PLC isoenzymes, cellular signaling
intracellular messengers
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
products are two second messengers
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
PLCbeta1 is involved in nuclear inositol lipid signaling
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
sperm-specific PLCzeta induces intracellular Ca2+ oscillations and subsequent early embryonic development when expressed in mouse eggs, PLCzeta may be the physiological mammalian egg-activating sperm factor
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
PI-PLC beta1 is essential in the IGF-1 mitogenic signaling pathway
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
part of the phosphoinositide signal transduction pathway
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
products are two second messengers
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
key enzyme in signal transduction generating the intracellular second messengers DAG and IP3
second messengers
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes
second messengers
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
saPLC1 employs a unique catalytic mechanism whereby the cleavage of phosphatidylinositol into inositol 1-phosphate occurs via a trans cyclization mechanism involving formation of inositol 1,6-cyclic phosphate as an intermediate
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
inositol phosphate/diacylglycerol signaling pathway, TcPI-PLC is lipid modified in vivo, TcPI-PLC is developmentally regulated, its expression is induced during the differentiation of trypomastigotes into amastigotes at an early stage in the transformation process
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
preferred substrate. With 1-phosphatidyl-1D-myo-inositol 4-phosphate, the enzyme displays a more than 3fold higher hydrolyzing activity compared to 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O
1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
-
-
-
?
additional information
?
-
-
AtPLC1S is involved in stress responses, AtPLC2 not
-
?
additional information
?
-
AtPLC2 is constitutively expressed
-
?
additional information
?
-
-
AtPLC2 is constitutively expressed
-
?
additional information
?
-
-
enzyme is phosphatidylinositol-specific and does not act on phosphatidylethanolamine and phosphatidylcholine
-
-
?
additional information
?
-
-
PLC eta enzyme influences intracellular Ca 2+ dynamics and protein kinase C activation in the brain and neuroendocrine systems as putative mediation of G-protein-coupled receptor regulationlikely mediates G-protein-coupled receptor signalling pathways
-
-
?
additional information
?
-
-
Isc1 only exerts IPC-PLC activity
-
-
?
additional information
?
-
-
Isc1 only exerts IPC-PLC activity
-
-
?
additional information
?
-
Drosophila sp. (in: flies)
-
PLC plays a key role in photoreceptor response
-
?
additional information
?
-
Drosophila sp. (in: flies)
-
phospholipase C is a key factor determining the photoreceptor sensitivity
-
-
?
additional information
?
-
-
the enzymes acting against [3H] inositol-phosphatidylinositol (PtdIns) and [3H] inositolphosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P2] in the cat carotid bodies (CB) are investigated using labelled phospholipids as a source of the substrate. Analysis of water soluble inositol metabolites indicates that PtdIns is degraded exclusively by the enzyme since the inositolmonophosphate (IP1) is detected as a single product. In case of PtdIns(4,5)P2 hydrolysis by carotid bodies (CB) enzymes there are all 3 inositol phosphates: IP3, IP2, IP1
-
-
?
additional information
?
-
-
phosphatidylinositol-phospholipase C plays a critical role, most likely through activation of protein kinase C pathway, in TLR4 mediated immune responses of avian macrophage cells to lipopolysaccharides
-
-
?
additional information
?
-
-
plays a critical role in signal transduction in the receptor-activated human platelets
-
-
?
additional information
?
-
-
cellular signaling, regulation of PLC activity
-
?
additional information
?
-
PLCgamma isoforms are regulated through activation of tyrosine kinase-linked receptors, importance of PLCgamma2 in B-cell signal transduction
-
?
additional information
?
-
-
PLCgamma isoforms are regulated through activation of tyrosine kinase-linked receptors, importance of PLCgamma2 in B-cell signal transduction
-
?
additional information
?
-
-
PLCgamma2 regulation, role in B-cell signalling
-
?
additional information
?
-
-
Gi-coupled receptors can inhibit PLC-epsilon, most likely by suppressing formation of cyclic AMP required for Epac-mediated Rap2B activation
-
-
?
additional information
?
-
-
interaction of phospholipase C-beta1 with cell polarity Par proteins may serve as a nexus to transduce extracellular signals to transcriptional reguation through G-protein-mediated signaling pathway in cell polarity and cell asymmetric division
-
-
?
additional information
?
-
-
involvement of phospholipase C signaling in melanoma cell-induced endothelial junction disassembly
-
-
?
additional information
?
-
-
PLC-eta enzymes may function in the membrane-mediated signaling cascade through intracellular Ca2+ and protein kinase C pathways
-
-
?
additional information
?
-
PLC-eta may perform fundamental roles in the brain
-
-
?
additional information
?
-
-
PLC-eta may perform fundamental roles in the brain
-
-
?
additional information
?
-
-
regulatory mechanisms controlling expression of PLCepsilon, broadened by diversity introduced by splice variants, could play important role in PLCepsilon regulation in normal and tumor cells
-
-
?
additional information
?
-
regulatory mechanisms controlling expression of PLCepsilon, broadened by diversity introduced by splice variants, could play important role in PLCepsilon regulation in normal and tumor cells
-
-
?
additional information
?
-
-
wild-type Rac GTPase with guanosine 5'-(3-O-thio)triphosphate causes a marked stimulation of PLCgamma2 but has no effect on the activity of PLCgamma1. The mechanism of PLCgamma2 activation by Rac GTPase involves neither protein phosphorylation nor PI3K-mediated generation of phosphatidylinositol 3,4,5-trisphosphate
-
-
?
additional information
?
-
phospholipase C beta3 is a key component in the Gbetagamma/PKCeta/PKD-mediated regulation of trans-Golgi network to plasma membrane transport
-
-
?
additional information
?
-
-
PLC eta enzyme influences intracellular Ca 2+ dynamics and protein kinase C activation in the brain and neuroendocrine systems as putative mediation of G-protein-coupled receptor regulation likely mediates G-protein-coupled receptor signalling pathways
-
-
?
additional information
?
-
PLC-beta2 may improve some malignant characteristics of tumor cells, like motility and invasion capability, but it fails to induce tumorigenesis in nontransformed breast-derived cells
-
-
?
additional information
?
-
-
PLC-beta2 may improve some malignant characteristics of tumor cells, like motility and invasion capability, but it fails to induce tumorigenesis in nontransformed breast-derived cells
-
-
?
additional information
?
-
-
suppression of Pi-PLC promotes apoptosis of vascular endothelial cells by inhibiting phosphorylation of Akt, elevating P53 expression, and affecting the cell cycle distribution. phosphatidyl-specific phospholipase C and phosphatidylcholine-specific phospholipase C might control the apoptosis by jointly regulating akt phosphorylation, P53 expression and affecting cell cycle in vascular endothelial cells
-
-
?
additional information
?
-
-
PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho
-
-
?
additional information
?
-
PI-PLC activity might be regulated by a heterotrimeric G protein
-
-
?
additional information
?
-
PI-PLC activity might be regulated by a heterotrimeric G protein
-
-
?
additional information
?
-
-
suPLCbeta is activated by G protein betagamma subunits
-
-
?
additional information
?
-
-
activation of PLCgamma by GTP during initial stages of formation of nuclear envelope provides a mechanism for temporal control of assembly of nuclear envelope
-
-
?
additional information
?
-
-
the activation of the gamma1 isoenzyme is a biologically important event in zona pellucida-stimulated inositol phospholipid metabolism with a potential role in signal transduction leading to acrosomal exocytosis
-
-
?
additional information
?
-
-
PLC delta1 is required for skin stem cell lineage commitment
-
?
additional information
?
-
-
PLC-beta1 is nessecary for the development and/or maintenance of brain inhibitory pathways, the retinal variants of PLC-beta4 function in signal processing within the retina, PLC-beta3 plays a role in the early development
-
?
additional information
?
-
-
phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy
-
-
?
additional information
?
-
-
PLC-eta enzymes may function in the membrane-mediated signaling cascade through intracellular Ca2+ and protein kinase C pathways
-
-
?
additional information
?
-
PLC-eta may perform fundamental roles in the brain
-
-
?
additional information
?
-
-
PLC-eta may perform fundamental roles in the brain
-
-
?
additional information
?
-
-
PLCgamma2 is crucial for development of the NL cell receptor repertoire and signaling of activating NK cell receptors, mediating optimal NL cell function in vivo
-
-
?
additional information
?
-
-
recombinant PLCzeta protein induces Ca2+ oscillations in mouse eggs
-
-
?
additional information
?
-
recombinant PLCzeta protein induces Ca2+ oscillations in mouse eggs
-
-
?
additional information
?
-
recombinant PLCzeta protein induces Ca2+ oscillations in mouse eggs
-
-
?
additional information
?
-
-
signaling of myelin phagocytosis mediated by complement-receptor-3 alone and by complement-receptor-3 combined with scavenger-receptor-AI/II involves phosphatidylinositol 3-kinase, phosphoinositide-specific phospholipase-Cgamma and protein kinase-C, the cascade phosphatidylinositol 3-kinase -> phosphoinositide-specific phospholipase-Cgamma -> protein kinase-C, and wide range modulation by protein kinase-C
-
-
?
additional information
?
-
the neuron-specific enzyme may be important for the formation and/or maintenance of the neuronal network in the postnatal brain
-
-
?
additional information
?
-
absolute requirement for PLC-gamma1 in villin-induced cell migration
-
-
?
additional information
?
-
-
inhibition of phosphatidylinositol 3-kinase may go through phosphoinositide-specific phospholipase C pathway leading to increase of expression of the inducible nitric oxide synthase, indicating that phosphatidylinositol 3-kinase and phosphoinositide-specific phospholipase C may counteract to regulate the metabolism of phosphatidylinositol (4,5)-bisphosphate depending on cell types or their conditions
-
-
?
additional information
?
-
overview: role of nuclear PI-PLCbeta1 in cell proliferation and differentiation
-
-
?
additional information
?
-
PLCepsilon is required for thrombin- but not lysophosphatidic acid-induced sustained ERK activation and DNA synthesis, providing a novel mechanism for G protein-coupled receptor and Rho signaling to cell proliferation. PLCepsilon has a role as a guanine nucleotide exchange factor for Rap1
-
-
?
additional information
?
-
PLCgamma2 is essential for RANK (Receptor activator of NF-kB) signaling, and its deficiency leads to defective lymph node organogenesis and osteoclast differentiation
-
-
?
additional information
?
-
-
PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho
-
-
?
additional information
?
-
-
PLC is involved in activation of the muscarinic receptor-operated cationic current in guinea pig ileal smooth muscle cells
-
-
?
additional information
?
-
-
enzyme is specific for phosphoinositides
-
-
?
additional information
?
-
-
significant role for PpPLC1 in cytokinin signalling and gravitropism
-
-
?
additional information
?
-
significant role for PpPLC1 in cytokinin signalling and gravitropism
-
-
?
additional information
?
-
-
the enzyme is involved in cytokinin and gravity responses
-
-
?
additional information
?
-
the enzyme is involved in cytokinin and gravity responses
-
-
?
additional information
?
-
PsPLC delta isoform is regulated by light in a tissue specific manner and may be involved in important functions
-
?
additional information
?
-
-
PsPLC delta isoform is regulated by light in a tissue specific manner and may be involved in important functions
-
?
additional information
?
-
-
PIP2-PLC is involved in the signal pathway that leads to the acquisition of heat acclimation
-
-
?
additional information
?
-
-
regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and betagamma subunits is dependent of enzyme subtype and concentration of Mg2+
-
-
?
additional information
?
-
-
the inositol lipid breakdown is controlled by different phosphoinositidase C isoenzymes in various cell compartments
-
-
?
additional information
?
-
-
the activation of the enzyme by m3-mascarinic acid receptor stimulation is mediated via alpha-subunit of the Gq/11 family of G-proteins
-
-
?
additional information
?
-
-
perturbation in a membrane in vivo equivalent to a non-bilayer configuration is sufficient to induce phosphodiesterase-catalyzed phosphatidylinositol 4,5-diphosphate breakdown
-
-
?
additional information
?
-
-
transformation-linked and progression-linked signal transduction enzyme
-
-
?
additional information
?
-
-
hepatocyte growth factor can activate phosphoinositidase C in rat hepatocytes
-
-
?
additional information
?
-
-
cellular signaling
-
?
additional information
?
-
PLCepsilon is a Ras effector, directly regulated by Ras and links two critical signaling pathways
-
?
additional information
?
-
-
activation of phospholipase C is a vital step in the neuronal protective adenosine-induced signal transduction pathway, conferring protection against iodoacetic acid-induced injury in primary rat neuronal cultures
-
-
?
additional information
?
-
-
Galpha12712- and Rho-dependent activation of phospholipase C-epsilon by lysophosphatidic acid and thrombin receptors
-
-
?
additional information
?
-
-
interaction of phospholipase C-beta1 with cell polarity Par proteins may serve as a nexus to transduce extracellular signals to transcriptional reguation through G-protein-mediated signaling pathway in cell polarity and cell asymmetric division
-
-
?
additional information
?
-
-
PLC activity is under tight dynamic control of the Ca2+ concentration. In insulin-secreting beta-cells, this mechanism provides a link between Ca2+ influx and release from intracellular stores that may be important in the regulation of insulin secretion
-
-
?
additional information
?
-
-
reduction in phospholipase C may be critical in the pathophysiology of depression and other stress-related disorders
-
-
?
additional information
?
-
-
inositide-dependent phospholipase C signaling mimics insulin in skeletal muscle differentiation by affecting specific regions of the cyclin D3 promoter
-
-
?
additional information
?
-
overview: role of nuclear PI-PLCbeta1 in cell proliferation and differentiation
-
-
?
additional information
?
-
-
PLC eta enzyme influences intracellular Ca 2+ dynamics and protein kinase C activation in the brain and neuroendocrine systems as putative mediation of G-protein-coupled receptor regulation likely mediates G-protein-coupled receptor signalling pathways
-
-
?
additional information
?
-
-
PLC activity in vascular smooth muscle cells can be divided into two types based on their calcium and pH requirements, substrate preferences, and molecular weights
-
-
?
additional information
?
-
-
several different assay conditions for both phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate are tested on samples of crude supernatant for their ability to support PLC activity
-
-
?
additional information
?
-
-
the injection fraction shows no activity against phosphatidylcholine
-
-
?
additional information
?
-
-
PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho
-
-
?
additional information
?
-
PLCepsilon is a Ras effector, directly regulated by Ras and links two critical signaling pathways
-
?
additional information
?
-
-
activation of PLCgamma by GTP during initial stages of formation of nuclear envelope provides a mechanism for temporal control of assembly of nuclear envelope
-
-
?
additional information
?
-
-
PLC-dsu is unlikely to be directly involved in the process of egg activation but may play a role in mediating extracellular signals transmitted via the phosphatidylinositol 3'-kinase pathway
-
-
?
additional information
?
-
-
the enzyme may participate in signal transduction over the plant plasma membrane
-
-
?
additional information
?
-
-
when expressed in plasma membrane, TcPI-PLC is involved in differentiation of trypomastigotes to amastigotes of Trypanosoma cruzi, an essential step for the intracellular replication of these parasites
-
-
?
additional information
?
-
-
the Vr-PLC3 protein is specifically activated by drought and salt stress in an abscisic acid-independent manner, with its induction being faster in roots than in leaf tissue
-
-
?
additional information
?
-
the Vr-PLC3 protein is specifically activated by drought and salt stress in an abscisic acid-independent manner, with its induction being faster in roots than in leaf tissue
-
-
?
additional information
?
-
the Vr-PLC3 protein is specifically activated by drought and salt stress in an abscisic acid-independent manner, with its induction being faster in roots than in leaf tissue
-
-
?
additional information
?
-
the Vr-PLC3 protein is specifically activated by drought and salt stress in an abscisic acid-independent manner, with its induction being faster in roots than in leaf tissue
-
-
?
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(1 -[6-[[17-beta-3-methoxyestra-1,3,5(10)-trien-17-yl]amino] hexyl]-1H-pyrrole-2,5-dione)
-
-
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid
Drosophila sp. (in: flies)
-
-
1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione
1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine
-
potent inhibitor
1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphorylcholine
-
histamine-induced elevation of plasma noradrenaline and adrenaline is dose-dependently reduced by ET-18-OCH3
3beta,27-dihydroxyurs-12-en-28-oic acid
3beta,7'-diacetoxy-27- 4-(E)-coumaroyloxyurs-12-en-28-oic acid
3beta-4-(E)-coumaroyloxyurs-12-en-28-oic acid
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
3beta-hydroxy-27-4-(E)-2'-dihydrocoumaroyloxyurs-12-en-28-oic acid
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic methyl ester
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
3beta-hydroxyurs-12-en-28-oic 4-(E)-coumaroyl ester
48/80
-
compound 48/80, oligomeric mixture of condensation products of N-methyl-p-methoxyphenethylamine and formaldehyde
aggregated amyloid beta protein
-
full-length Abeta 1-40, aggregated form inhibits Ca2+-regulated phosphoinositide degradation by cytosolic and membrane-bound PLC by 30-40%, inhibitor may interact with the Ca2+-binding site of enzyme, no inhibition by nonaggregated soluble full-length amyloid beta protein
-
anionic amphipathic substances
-
-
-
Blood lipoprotein
-
enzyme is strongly inhibited by blood plasma, serum and blood lipoproteins
-
Blood plasma
-
enzyme is strongly inhibited by blood plasma, serum and blood lipoproteins
-
Blood serum
-
enzyme is strongly inhibited by blood plasma, serum and blood lipoproteins
-
CaCl2
-
above 0.4 mM, pH 7.0
camphor
-
inhibit the phospholipase C signaling
chlorpromazine
-
at pH 7.0
cholic acid
-
inhibits PLC-beta1 activity
cinnamaldehyde
-
inhibit the phospholipase C signaling
CRM-51006
-
i.e. 1-(3-ethyl-2,4-dihydroxyphenyl)-2-methylhexan-1-one
Cu2+
-
is effective only after preincubation, suggesting that the effect of the metal may be derived from lipid peroxidation due to Cu2+-induced oxyradical production
CuCl2
-
0.1 mM, 53% inhibition
dibromo 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid
Drosophila sp. (in: flies)
-
-
diethyl ether
-
25% v/v, 22% inhibition
edelfosine
-
ET-18-OCH3, also inhibits Ca2+-induced inactivation of TRPV6
guanosine 5'-[gamma-thio]triphosphate
-
activity is downregulated by 1-10 mM guanosine 5'-[gamma-thio]triphosphate
iodoacetamide
-
1.0 mM, 16% inhibition
La3+
-
at 0.05-5 mM, inhibition is completely reversed by Ca2+
lysocholine plasmalogen
-
menthol
-
inhibit the phospholipase C signaling
Mn2+
-
at 0.05-5 mM, inhibition is completely reversed by Ca2+
NaCl
-
inhibits phosphatidylinositol hydrolysis of low molecular weight PLC. Conversely, PIP2 hydrolysis is stimulated by increasing concentrations of NaCl
NEM
-
5 mM, 34% inhibition
nod factor
-
activity is decreased by up to 64% in the presence of increasing concentrations of Nod factors
-
Octadecylamine
-
decreases the film pressure of the phosphatidylinositol monolayer at an air/water interface at which cut-off occurs, as well as the rate of hydrolysis below this pressures
Palmitoylcholine
-
decreases the film pressure of the phosphatidylinositol monolayer at an air/water interface at which cut-off occurs, as well as the rate of hydrolysis below this pressures
phosphatidylethanolamine
-
25% inhibition, in presence of 0.001 mM Ca2+
putrescine
-
putrescine is less efficient than divalent cations in reducing isoform PLCbeta1 activity
sodium deoxycholate
-
activates from 0.05% to 0.08%, but severely inhibits activity above 0.08%, no activity at 0.3%
Sr2+
-
at higher concentrations (greater than 0.25 mM) markedly inhibited, inhibition is completely reversed by Ca2+
substance 48/80
inhibition is more pronounced with phosphatidylinositol as substrate than with 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
Triton X-100
-
inhibits PLC-beta1 activity
1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione
-
significant inhibition of PLC-beta with IC50: 0.006 mM, little effect on PLC-beta1, PLC-beta3, or PLC-beta4
1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione
-
U73122, also inhibits Ca2+-induced inactivation of TRPV6
1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione
-
U-73122
3beta,27-dihydroxyurs-12-en-28-oic acid
-
-
3beta,27-dihydroxyurs-12-en-28-oic acid
-
-
3beta,7'-diacetoxy-27- 4-(E)-coumaroyloxyurs-12-en-28-oic acid
-
-
3beta,7'-diacetoxy-27- 4-(E)-coumaroyloxyurs-12-en-28-oic acid
-
-
3beta-4-(E)-coumaroyloxyurs-12-en-28-oic acid
-
-
3beta-4-(E)-coumaroyloxyurs-12-en-28-oic acid
-
-
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
-
-
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
-
-
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
-
-
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
-
-
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
-
-
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
-
-
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
-
-
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
-
-
3beta-hydroxy-27-4-(E)-2'-dihydrocoumaroyloxyurs-12-en-28-oic acid
-
-
3beta-hydroxy-27-4-(E)-2'-dihydrocoumaroyloxyurs-12-en-28-oic acid
-
-
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
-
-
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
-
-
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
-
-
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
-
-
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic methyl ester
-
-
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic methyl ester
-
-
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
-
-
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
-
-
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
-
-
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
-
-
3beta-hydroxyurs-12-en-28-oic 4-(E)-coumaroyl ester
-
-
3beta-hydroxyurs-12-en-28-oic 4-(E)-coumaroyl ester
-
-
4-(E)-coumaric acid
-
-
adriamycin
-
-
amentoflavone
-
-
Ba2+
-
-
Ba2+
-
at 0.05-5 mM, inhibition is completely reversed by Ca2+
Ca2+
-
at high concentrations
Ca2+
-
concentrations above 1 mM are inhibitory
Ca2+
when phosphatidylinositol is used as a substrate, the enzyme activity increases with increasing free Ca2+ concentrations above 1 µM, and the activity decreases when free Ca2+-concentration exceeded 1 mM. When 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is used as substrate, the enzyme is activated at lower Ca2+-concentrations and its activity increases with increasing free Ca2+ concentration. Addition of 3 mM MgCl2 stimulates hydrolysis 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate and inhibites hydrolysis of phosphatidylinositol
choline plasmalogen
-
18.5% of choline plasmalogen is needed for 50% inhibition
choline plasmalogen
-
18.5% of choline plasmalogen is needed for 50% inhibition
Cys
-
5 mM, 58% inhibition
deoxycholate
-
0.1 mM, inhibits basal and phosphatidic acid-stimulated PLC-beta1 activity
deoxycholate
-
weak inhibition. Concentration of 2 mM inhibits the phospholipase C activity in all fractions by 20-30%
deoxycholate
-
weak inhibition. Concentration of 2 mM inhibits the phospholipase C activity in all fractions by 20-30%
EDTA
-
addition of EDTA completely inhibits the activity
EDTA
-
complete inhibition at 1 mM
EDTA
-
2 mM, 70% inhibition
EDTA
-
inhibition by EDTA can be reverted upon the addition of increasing concentrations of Ca2+ and Mg2+ in the assay
EDTA
-
1 mM, 52% inhibition
EDTA
-
at 0.05-5 mM, inhibition is completely reversed by Ca2+
EGTA
-
-
EGTA
-
at 0.05-5 mM, inhibition is completely reversed by Ca2+
Hg2+
-
0.1 mM, 90% inhibition
Hg2+
-
inhibits PLC activity when added directly to the reaction mixture. Toxic effect stronger than that of Cu2+ both in vitro and in vivo, especially for the digestive gland
lysocholine plasmalogen
-
8.5% of choline plasmalogen is needed for 50% inhibition
-
lysocholine plasmalogen
-
8.5% of choline plasmalogen is needed for 50% inhibition
-
lysophosphatidylcholine
-
50% inhibition is produced by 7% molar
lysophosphatidylcholine
-
50% inhibition is produced by 7% molar
lysophosphatidylcholine
-
C12, C14 and C16 lysophosphatidylcholines give progressive inhibition with increasing chain length
Mg2+
-
-
Mg2+
-
at 0.05-5 mM, inhibition is completely reversed by Ca2+
Mg2+
hydrolysis of phosphatidylinositol
MgCl2
-
0.1-1 mM, 20% inhibition
MgCl2
-
1 mM MgCl2, in presence of free Ca2+
MgCl2
-
above 0.4 mM, pH 7.0
neomycin
-
-
neomycin
-
neomycin does not inhibit the enzyme activity completely
neomycin
hydrolysis of phosphatidylinositol and 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
oleoyl sphingomyelin
-
-
PCMB
-
0.5 mM, 78% inhibition
Phenylmercuriacetate
-
0.1 mM, 85% inhibition
phosphatidylcholine
-
slightly inhibited, 30% at concentrations equimolar with phosphatidylinositol
phosphatidylcholine
-
low effect, 50% inhibition is produced by 18% molar egg phosphatidylcholine
phosphatidylcholine
-
little effect, 50% inhibition is produced by 18% molar egg phosphatidylcholine
phosphatidylcholine
-
the enzyme is strongly inhibited when ovophosphatidylcholine and saturated phosphatidylcholines with acyl chain length of more than eight carbon atoms are mixed with its substrate
phosphatidylcholine
-
decreases the film pressure of the phosphatidylinositol monolayer at an air/water interface at which cut-off occurs, as well as the rate of hydrolysis below this pressures
phosphatidylserine
-
30 mol%, slight PLC-beta1 inhibition
phosphatidylserine
-
50% inhibition, in presence of 0.001 mM Ca2+
reduced glutathione
-
6.8 mM, 35% inhibition
sphingomyelin
-
50% inhibition at 6.5% molar, and 97% at 20% molar
sphingomyelin
-
50% inhibition at low concentration, and 97% at high concentration
sphingosylphosphocholine
-
-
sphingosylphosphocholine
-
-
stearoyl sphingomyelin
-
-
stearoyl sphingomyelin
-
-
U-73122
-
-
U-73122
PLC inhibitor, inhibits growth of Cryptococcus neoformans; PLC inhibitor, inhibits growth of Cryptococcus neoformans
U-73122
aminosteroid inhibitor¸ the two recombinant enzymes synthesized from two potential initiation codons differ in the sensitivity
U-73122
-
specific PLC inhibitor
U-73122
-
PLC inhibitor inhibits Ca2+-induced inactivation of TRPV6 in patch-clamp experiments
U-73122
-
histamine-induced elevation of plasma noradrenaline and adrenaline is dose-dependently reduced by U-73122
U-73343
-
-
U-73343
-
inactive analog of U-73122
U73122
-
-
U73122
-
direct activation of PI-PLC though Ca2+ may bypass inhibition by U73122, PI-PLC activity is not sensitive to U73122 when activated by the Ca2+ ionophore A23187. Unphysiologically high Ca2+ levels can overcome PI-PLC inhibition by U73122
U73122
-
effectively blocks the effect of insulin on the release of GPI-renal dipeptidase
U73122
-
i.e. 1-(6-([17beta-3-methoxyestra-1,3,5(10)-trien-17-yl]amino)hexyl)-1H-pyrrole-2,5-dione, one of the isozymes is inhibited
additional information
-
dialysis of the Apium graveolens var. dulce extract against water completely inhibits the activity
-
additional information
-
enzyme is not inhibited by 1.7 mM p-bromophenacylbromide
-
additional information
-
regulation of the PLC delta isoenzymes
-
additional information
inactive analogue control (U73343) has no antifungal activity against Cryptococcus neoformans; inactive analogue control (U-73343) has no antifungal activity against Cryptococcus neoformans. Deltaplc1 is hypersusceptible to flucytosine, azoles and amphotericin B, but not to caspofungin
-
additional information
inactive analogue control (U73343) has no antifungal activity against Cryptococcus neoformans; inactive analogue control (U-73343) has no antifungal activity against Cryptococcus neoformans. Deltaplc1 is hypersusceptible to flucytosine, azoles and amphotericin B, but not to caspofungin
-
additional information
not inhibited by U-73343
-
additional information
-
enzyme is substantially inhibited by all phospholipids containing a phosphocholine head group. The sphingosine-containing phospholipids are the most inhibitory; phosphatidic acid does not inhibit
-
additional information
-
regulation of the PLC delta isoenzymes
-
additional information
-
LY294002 inhibits the BCR-induced PLC activation in Ramos cells in a dose-dependent manner
-
additional information
LY294002 inhibits the BCR-induced PLC activation in Ramos cells in a dose-dependent manner
-
additional information
-
experimental metastasis assays with tetracycline in nude mice show that inducible knockdown of PLCgamma1 strongly inhibits development of MDA-MB-231-derived lung metastasis and reverts metastasis formation
-
additional information
-
SFD-1-mediated inactivation of ERM (ezrin/radixin/moesin) proteins is blocked by phospholipase C inhibitors
-
additional information
-
inactive analog U73343 also used
-
additional information
-
not inhibited by 1-[6-[((17beta)-3-methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-2,5-pyrrolidinedione (i.e. U-73343)
-
additional information
-
treatment of mussels with sublethal concentrations of Hg2+ or Cu2+ in vivo produces significant PLC inhibition after 1 or 4 days, respectively. A recovery is reached after 7 days of in vivo metal incubation. Data indicate that in mussel gills and digestive gland heavy metals impair PLC activity, thereby affecting IP3-dependent Ca2+ signaling
-
additional information
-
enzyme is substantially inhibited by all phospholipids containing a phosphocholine head group. The sphingosine-containing phospholipids are the most inhibitory; phosphatidic acid does not inhibit
-
additional information
-
regulation of the PLC delta isoenzymes, under hyperoxia conditions acrylonitrile decreases PLC delta1 level, PLC delta4 gene is down-regulated after spinal cord injury
-
additional information
-
mepacrine (PLA2 inhibitor) and D609 (phosphatidylcholine-specific PLC inhibitor) have no effect. Histamine-induced elevation of plasma noradrenaline and adrenaline is also dose-dependently reduced by RHC-80267 (diacylglycerol lipase inhibitor)
-
additional information
increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist; increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist; increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist; increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist
-
additional information
increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist; increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist; increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist; increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist
-
additional information
increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist; increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist; increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist; increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist
-
additional information
increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist; increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist; increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist; increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist
-
additional information
-
not inhibited by U-73343
-
additional information
-
D609 has no effect
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2-{4-methoxy-3,5-bis-[2-methoxy-5-(2-methylamino-ethyl)-benzyl]-phenyl}-ethyl)-methyl amine
-
compound 48/80 i.e. (2-{4-methoxy-3,5-bis-[2-methoxy-5-(2-methylamino-ethyl)-benzyl]-phenyl}-ethyl)-methyl amine, CAS REG. NO.: 94724-12-6, the calmodulin antagonists activate at least one form of the rod outer segment enzyme by a calmodulin-independent mechanism
2-nonenal
-
at 1-100 nM: activates PL-C in DMSO-differentiated HL-60 cells, at 1-10 nM: activates PL-C in undifferentiated HL-60 cells
4-hydroxynonenal
-
at 10-1000 nM, activates PL-C in both undifferentiated and DMSO-differentiated HL-60 cells
activated Galpha proteins
-
-
-
albumin
-
maximal activation of hydrolysis of phosphatidylinositol 4,5-diphosphate at 0.0125 mg/ml
-
arachidonic acid
-
enhances hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme and cytosolic enzyme
ARGHAP6
a GTPase-activating protein for RhoA. Activates PLC-gamma1 and increases the Vmax of PLC-beta1 and enhances its response to Ca2+ stimulation. ARHGAP6 protein binds to and up-regulates PLC-beta1 both under in vitro and in vivo conditions
-
B cell antigen receptor
-
induces activation of PLC-gamma2, pathway
-
Calmidazolium
-
the calmodulin antagonists activate at least one form of the rod outer segment enzyme by a calmodulin-independent mechanism
Calmodulin antagonists
-
activate at least one form of the rod outer segment enzyme by a calmodulin-independent mechanism
-
Carbachol
-
small stimulatory effect of about 30% on the enzyme acting on PtdIns(4,5)P2. GTPgammaS enhances this effect
cetyltrimethylammonium bromide
-
stimulates
chlorpromazine
-
stimulates at pH 5.5
Cinchocaine
-
stimulates at pH 5.5
cytochrome c
-
maximal activation of hydrolysis of phosphatidylinositol 4,5-diphosphate at 0.0125 mg/ml
decanoylglycerophosphate
-
only little activating effect
decanoyllysophosphatidylcholine
-
C10 lysophosphatidylcholine activates the reaction
diethyl ether
-
stimulates
dihexanoylglycerophosphocholine
-
-
dopamine
-
small stimulatory effect of about 30% on the enzyme acting on PtdIns(4,5)P2. GTPgammaS enhances this effect
G protein alpha12
-
activates PLC-epsilon
-
G protein qalpha
-
activates PLC-beta isoenzymes, G protein-coupled receptor-mediated activation
-
Gbetagamma
G protein betagamma subunits, the reconstituted enzymes, like wild-type PLC-beta2, are activated by Gbetagamma
-
inositol 1,2-(cyclic)-phosphate
-
Insulin
-
in part, may activate GPI-PLC, via phosphatidylinositol-specific phospholipase C/intracellular Ca2+, which may consequently stimulate the release of GPI-renal dipeptidase
-
insulin-like growth factor 1
-
stimulates nuclear PLCbeta1, through translocation of MAP kinase to the nucleus
-
lysophosphatidic acid
-
slight activation, less effective in stimulating PLC-beta1 activity than phosphatidic acid
mannitol
drought treatment
MAP kinase
-
phosphorylates and activates nuclear PLCbeta1
-
mastoparan
-
activity almost doubled in the presence of 5 microM
Melittin
-
the calmodulin antagonists activate at least one form of the rod outer segment enzyme by a calmodulin-independent mechanism
N-(3-trifluoromethyl-phenyl)-2,4,6-trimethylbenzenesulfonamide
-
-
N-(4-aminobutyl)-5-chloro-1-naphthalenesulfonamide
-
the calmodulin antagonists activate at least one form of the rod outer segment enzyme by a calmodulin-independent mechanism
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide
-
the calmodulin antagonists activate at least one form of the rod outer segment enzyme by a calmodulin-independent mechanism
oleoylglycerophosphate
-
activates the hydrolysis at a physiological pH
oleyl alcohol
-
increases the film pressure of the phosphatidylinositol monolayer at an air/water interface at which cut-off occurs, as well as increases the rate of hydrolysis at lower pressures
palmitoylglycerophosphate
-
activates the hydrolysis at a physiological pH
phosphatidylcholine
-
enhances hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme
phosphatidylglycerol
-
increases the film pressure of the phosphatidylinositol monolayer at an air/water interface at which cut-off occurs, as well as increases the rate of hydrolysis at lower pressures
PTEN
-
ubiquitously expressed tumor suppressor. PTEN overexpression results in changes in cellular phospholipid levels. Increased PTEN expression in unstimulated MCF-7 breast cancer cells results in a 51% increase in phosphatidic acid, with a decrease in phosphatidylcholine, PTEN activates also phospholipase D (PLD). PTEN induces translocation of PLC-gamma from the cytosol to the membrane
-
Q61L H-Ras
constitutively active Q61L H-Ras stimulates PLCepsilon co-expressed in COS-7 cells in parallel with Ras binding
-
Ras
-
activator of PLC-epsilon
-
receptor protein tyrosine kinase
-
activates PLC-gamma, growth factor receptor-mediated activation
-
RhoA
-
PLC-epsilon is a direct downstream efector for RhoA. RhA-dependent activation of PLC-epsilon depends on a unique insert within the catalytic core of the phospholipase
sodium deoxycholate
-
activates from 0.05% to 0.08%, but severely inhibits activity above 0.08%, no activity at 0.3%
soluble amyloid beta protein fragment 25-35
-
activates PI-PLC
-
sphingosine 1-phosphate
sphingosine-1-phosphate stimulates PI-PLC activity of both splice variants
T cell antigen receptor
-
induces activation of PLC-gamma1, pathway
-
Trifluoperazine
-
the calmodulin antagonists activate at least one form of the rod outer segment enzyme by a calmodulin-independent mechanism
xanthurenic acid
-
triggers the hydrolysis of phosphoinositide by PI-PLC in gametocytes
Ca2+
-
requirement of all PLCs, the delta isoenzymes are most sensitive to Ca2+
Ca2+
-
the enzyme acting on PtdIns is Ca2+-dependent, in contrary to that acting on PtdIns(4,5)P2 which remains active in the presence of 10 mM EGTA
Ca2+
-
requirement of all PLCs, the delta isoenzymes are most sensitive to Ca2+
Ca2+
-
requirement of all PLCs, the delta isoenzymes are most sensitive to Ca2+
deoxycholate
-
stimulates activity of enzyme I, II and III at pH 7
deoxycholate
-
required for activity with membrane-bound phosphatidylinositol, slight stimulation with isolated phosphatidylinositol
diacylglycerol
-
at 22°C, diacylglycerol at 33 mol% increases enzyme activity in mixtures of phosphatidylinositol with dimyristoyl phosphatidylcholine, distearoyl phosphatidylcholine, sphingomyelin, or galactosylceramide, but not in pure phosphatidylinositol bilayers
diacylglycerol
-
little activating effect on PLC-beta1
diacylglycerol
-
the addition of choline phospholipids containing two long hydrophobic chains or choline lysophospholipids containing one long hydrophobic chain produced a total inhibition of the activation which had been produced by diacylglycerol
diacylglycerol
-
enhances hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme and cytosolic enzyme
diacylglycerol
-
5-6fold stimulation of rat brain phosphatidylinositol phosphodiesterase. The addition of choline phospholipids containing two long hydrophobic chains or choline lysophospholipids containing one long hydrophobic chain produced a total inhibition of the activation which had been produced by diacylglycerol
Epidermal growth factor
epidermal growth factor stimulates PI-PLC activity of both splice variants
Epidermal growth factor
stimulates PLCepsilon overexpressed in COS-7 cells
G protein betagamma
-
may be the main positive regulator of DdPLC
-
G protein betagamma
-
activates PLC-beta isoenzymes with the exception of PLC-beta4
-
GTPgammaS
-
PtdIns(4,5)P2-PLC is stimulated by GTPgammaS. Enzyme acting on PtdIns is not activated by GTPgS
GTPgammaS
-
one of the isozymes is activated by GTPgammaS in vitro
histone
-
activates
histone
-
maximal activation of hydrolysis of phosphatidylinositol 4,5-diphosphate at 0.0125 mg/ml
oleic acid
-
little activating effect on PLC-beta1
oleic acid
-
causes a marked stimulation of the enzyme activity when the membrane-bound substrate is used
oleic acid
-
markedly increases rate of hydrolysis
phosphatidic acid
-
stimulating
phosphatidic acid
-
PLC-beta1 activation, Ca2+-dependent, relatively independent of acyl chain length, stimulates basal and receptor-G protein-regulated PLC-beta1 activity, activation occurs through an C-terminal-dependent and an independent mechanism
phosphatidic acid
-
enhances hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme and cytosolic enzyme
phosphatidic acid
-
activates the hydrolysis at a physiological pH
phosphatidic acid
-
increases the film pressure of the phosphatidylinositol monolayer at an air/water interface at which cut-off occurs, as well as increases the rate of hydrolysis at lower pressure
phosphatidylethanolamine
-
stimulation in presence of 1 mM Ca2+
phosphatidylethanolamine
-
activates the hydrolysis. Human platelet phosphatidylinositol phosphodiesterase
phosphatidylethanolamine
-
enhances hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme and cytosolic enzyme
phosphatidylethanolamine
-
activates the hydrolysis. Human platelet phosphatidylinositol phosphodiesterase
phosphatidylethanolamine
-
slightly increases rate of hydrolysis
phosphatidylserine
-
stimulation in presence of 1 mM Ca2+
phosphatidylserine
-
enhances hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme
spermine
-
spermine
-
spermine potentiates the activity of isoform PLCgamma1
additional information
AtPLC is induced in response to salt, abscisic acid, cold and dehydration. Relative expression levels of AtPLC gene family in response to environmental stimuli is shown
-
additional information
AtPLC is induced in response to salt, abscisic acid, cold and dehydration. Relative expression levels of AtPLC gene family in response to environmental stimuli is shown
-
additional information
AtPLC is induced in response to salt, abscisic acid, cold and dehydration. Relative expression levels of AtPLC gene family in response to environmental stimuli is shown
-
additional information
AtPLC is induced in response to salt, abscisic acid, cold and dehydration. Relative expression levels of AtPLC gene family in response to environmental stimuli is shown
-
additional information
AtPLC is induced in response to salt, abscisic acid, cold and dehydration. Relative expression levels of AtPLC gene family in response to environmental stimuli is shown
-
additional information
AtPLC is induced in response to salt, abscisic acid, cold and dehydration. Relative expression levels of AtPLC gene family in response to environmental stimuli is shown
-
additional information
AtPLC is induced in response to salt, abscisic acid, cold and dehydration. Relative expression levels of AtPLC gene family in response to environmental stimuli is shown
-
additional information
AtPLC is induced in response to salt, abscisic acid, cold and dehydration. Relative expression levels of AtPLC gene family in response to environmental stimuli is shown
-
additional information
AtPLC is induced in response to salt, abscisic acid, cold and dehydration. Relative expression levels of AtPLC gene family in response to environmental stimuli is shown
-
additional information
-
AtPLC is induced in response to salt, abscisic acid, cold and dehydration. Relative expression levels of AtPLC gene family in response to environmental stimuli is shown
-
additional information
-
cleavage of GPI-anchored proteins by PI-PLC is influenced by bilayer fluidity, higher fluidity activates
-
additional information
-
PLC-beta1 is not activated by phosphatidylserine, anionic and neutral detergents
-
additional information
-
regulation of the PLC delta isoenzymes
-
additional information
-
membrane targeting of PLCgamma2 constructs containing either PLCdelta1 PH domain or the N-terminal tag of Lyn results in enzyme activation, phosphorylation of PLCgamma2 increases enzyme activity, raft targeting is essential for the B-cell antigen receptor and also for the H2O2 stress-induced 1D-myo-inositol 1,4,5-trisphosphate production in DT40 B-cell line
-
additional information
-
regulation of the PLC delta isoenzymes
-
additional information
-
activation of PLC is essential for SDF-1-induced ERM (ezrin/radixin/moesin) protein release from cortical membrane and dephosphorylation
-
additional information
recruitment of PLC-gamma1 to nephrin activated PLC-gamma1, as detected by phosphorylation of PLC-gamma1 Tyr-783 and increase in inositol 1,4,5-trisphosphate level
-
additional information
regulated by G protein subunits
-
additional information
-
treatment with 5-aza-2'deoxycytidine, an inhibitor of DNA methylation, results in an expression of PLCepsilon1b in tumor cells
-
additional information
treatment with 5-aza-2'deoxycytidine, an inhibitor of DNA methylation, results in an expression of PLCepsilon1b in tumor cells
-
additional information
-
spermine does not stimulate the activity of isoform PLCbeta1
-
additional information
activation by amphiphiles occurs with both micellar (phosphatidylinositol dispersed in detergents) and monomeric [dibutroylphosphatidylinositol (diC4PI)] phosphotransferase substrates and inositol 1,2-(cyclic)-phosphate (cIP), the phosphodiesterase substrate
-
additional information
-
activation by amphiphiles occurs with both micellar (phosphatidylinositol dispersed in detergents) and monomeric [dibutroylphosphatidylinositol (diC4PI)] phosphotransferase substrates and inositol 1,2-(cyclic)-phosphate (cIP), the phosphodiesterase substrate
-
additional information
-
modes of activation/activation pathways of the PLC isoenzymes beta, gamma, delta and epsilon
-
additional information
-
the activation of PLCgamma2 is dependent on Syk and Src family kinases
-
additional information
-
the enzyme is not stimulated by sodium deoxycholate
-
additional information
-
extremely low frequency electromagnetic fields affect the phosphoinositide signal transduction pathway by triggering the PI-PLC activation and the consequent phosphatidylinositol 4,5-bisphosphate breakdown
-
additional information
-
assay of the effect of Nod factors on in vitro PLC activity from nodule membrane fractions in the presence of guanosine 5'-[gamma-thio]triphosphate (GTPgammaS) and mastoparan
-
additional information
-
rat brain protein kinase C phosphorylates phosphoinositidase gamma but not phosphoinositidase beta1. Incubation with the kinase increases the activity of both enzymes however, possibly by phosphorylation of another protein in the preparations
-
additional information
-
regulation of the PLC delta isoenzymes, acrylonitrile causes a significant increase in PLC delta1 level in the heart and cytosol of cerebral cortex
-
additional information
study of PLCepsilon activation by several Ras mutants, recombinant purified PLCepsilon is not activated by Galpha-q, Gbetagamma or H-Ras in vitro
-
additional information
norepinephrine increases PLC beta1, beta3, gamma1, and delta1 isozyme gene expression
-
additional information
norepinephrine increases PLC beta1, beta3, gamma1, and delta1 isozyme gene expression
-
additional information
norepinephrine increases PLC beta1, beta3, gamma1, and delta1 isozyme gene expression
-
additional information
norepinephrine increases PLC beta1, beta3, gamma1, and delta1 isozyme gene expression
-
additional information
-
sodium lauryl sulfate, tetradecyl-trimethylammonium bromide, and Triton X-100 do not activate phosphatidylinositol phosphodiesterase in the presence of Ca2+
-
additional information
-
the enzyme is not stimulated by sodium deoxycholate
-
additional information
TcPI-PLC expression is induced during the differentiation of trypomastigotes into amastigotes
-
additional information
-
TcPI-PLC expression is induced during the differentiation of trypomastigotes into amastigotes
-
additional information
-
expression is induced by abiotic stress
-
additional information
expression is induced by abiotic stress
-
additional information
expression is induced by abiotic stress
-
additional information
expression is induced by abiotic stress
-
additional information
-
expression is induced by abiotic stress. The expression of Vr-PLC3 mRNA is unaffected by treatment with exogenous abscisic acid for 24 h. This raises the possibility that water and salt stress induction of Vr-PLC3 is mediated by an abscisic acid-independent pathway
-
additional information
expression is induced by abiotic stress. The expression of Vr-PLC3 mRNA is unaffected by treatment with exogenous abscisic acid for 24 h. This raises the possibility that water and salt stress induction of Vr-PLC3 is mediated by an abscisic acid-independent pathway
-
additional information
expression is induced by abiotic stress. The expression of Vr-PLC3 mRNA is unaffected by treatment with exogenous abscisic acid for 24 h. This raises the possibility that water and salt stress induction of Vr-PLC3 is mediated by an abscisic acid-independent pathway
-
additional information
expression is induced by abiotic stress. The expression of Vr-PLC3 mRNA is unaffected by treatment with exogenous abscisic acid for 24 h. This raises the possibility that water and salt stress induction of Vr-PLC3 is mediated by an abscisic acid-independent pathway
-
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0.006
1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
significant inhibition of PLC-beta with IC50: 0.006 mM, little effect on PLC-beta1, PLC-beta3, or PLC-beta4
0.001 - 0.0666
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
0.0028 - 0.0355
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
0.0021 - 0.0503
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
0.0009 - 0.0441
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
0.0836
3beta-hydroxy-27-4-(E)-2'-dihydrocoumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
pH 7.0, 37°C
0.0008 - 0.0524
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
0.0009 - 0.0737
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
0.1213
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic methyl ester
Homo sapiens
-
pH 7.0, 37°C
0.0017 - 0.059
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
0.0014 - 0.0733
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
0.0001 - 0.0246
adriamycin
0.029
amentoflavone
Homo sapiens
-
pH 7.0, 37°C
0.003
U73122
Plasmodium berghei
-
pH and temperature not specified in the publication
additional information
additional information
-
0.001
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in A549 cells, pH 7.0, 37°C
0.0018
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0021
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0021
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, pH 7.0, 37°C
0.003
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in MCF7 cells, pH 7.0, 37°C
0.0054
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HT-1 197 cells, pH 7.0, 37°C
0.0182
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
Mus musculus
-
in P388 cells, pH 7.0, 37°C
0.0357
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
pH 7.0, 37°C
0.0666
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in CCD-18Co cells, pH 7.0, 37°C
0.0028
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0029
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0029
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, pH 7.0, 37°C
0.0091
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HT-1 197 cells, pH 7.0, 37°C
0.0091
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in MCF7 cells, pH 7.0, 37°C
0.01
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in A549 cells, pH 7.0, 37°C
0.0143
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
pH 7.0, 37°C
0.0229
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
Mus musculus
-
in P388 cells, pH 7.0, 37°C
0.0355
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in CCD-18Co cells, pH 7.0, 37°C
0.0021
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0021
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, pH 7.0, 37°C
0.0027
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in A549 cells, pH 7.0, 37°C
0.0035
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HT-1 197 cells, pH 7.0, 37°C
0.004
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in MCF7 cells, pH 7.0, 37°C
0.0065
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0175
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
Mus musculus
-
in P388 cells, pH 7.0, 37°C
0.0446
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
pH 7.0, 37°C
0.0503
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in CCD-18Co cells, pH 7.0, 37°C
0.0009
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in MCF7 cells, pH 7.0, 37°C
0.0038
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0038
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, pH 7.0, 37°C
0.0041
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0043
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in A549 cells, pH 7.0, 37°C
0.0067
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HT-1 197 cells, pH 7.0, 37°C
0.0229
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
Mus musculus
-
in P388 cells, pH 7.0, 37°C
0.0438
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in CCD-18Co cells, pH 7.0, 37°C
0.0441
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
pH 7.0, 37°C
0.0008
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0008
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, pH 7.0, 37°C
0.0019
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in MCF7 cells, pH 7.0, 37°C
0.002
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0037
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HT-1 197 cells, pH 7.0, 37°C
0.0066
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in A549 cells, pH 7.0, 37°C
0.0186
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
Mus musculus
-
in P388 cells, pH 7.0, 37°C
0.022
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
pH 7.0, 37°C
0.0524
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in CCD-18Co cells, pH 7.0, 37°C
0.0009
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in MCF7 cells, pH 7.0, 37°C
0.0024
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0038
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in A549 cells, pH 7.0, 37°C
0.0045
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0045
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, pH 7.0, 37°C
0.0051
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HT-1 197 cells, pH 7.0, 37°C
0.0095
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
pH 7.0, 37°C
0.0226
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Mus musculus
-
in P388 cells, pH 7.0, 37°C
0.0614
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
sulforhodamine B, cytotoxic effects of 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid on the HCT-15 cell line by the sulforhodamine B (SRB) and colony forming assays, pH 7.0, 37°C
0.065
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in CCD-18Co cells, pH 7.0, 37°C
0.0737
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
colony-forming, cytotoxic effects of 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid on the HCT-15 cell line by the sulforhodamine B (SRB) and colony forming assays, pH 7.0, 37°C
0.0017
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HT-1 197 cells, pH 7.0, 37°C
0.0021
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0021
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0021
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, pH 7.0, 37°C
0.0021
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in MCF7 cells, pH 7.0, 37°C
0.0032
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in A549 cells, pH 7.0, 37°C
0.0174
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
Mus musculus
-
in P388 cells, pH 7.0, 37°C
0.0277
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
pH 7.0, 37°C
0.059
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in CCD-18Co cells, pH 7.0, 37°C
0.0014
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in MCF7 cells, pH 7.0, 37°C
0.0043
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0043
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, pH 7.0, 37°C
0.0047
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0072
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HT-1 197 cells, pH 7.0, 37°C
0.0076
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in A549 cells, pH 7.0, 37°C
0.0245
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
pH 7.0, 37°C
0.0245
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
Mus musculus
-
in P388 cells, pH 7.0, 37°C
0.0733
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in CCD-18Co cells, pH 7.0, 37°C
0.0001
adriamycin
Homo sapiens
-
in HT-1 197 cells, pH 7.0, 37°C
0.0004
adriamycin
Homo sapiens
-
colony-forming, cytotoxic effects of 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid on the HCT-15 cell line by the sulforhodamine B (SRB) and colony forming assays, pH 7.0, 37°C
0.0007
adriamycin
Homo sapiens
-
colony-forming, cytotoxic effects of 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid on the A549 cell line by the sulforhodamine B (SRB) and colony forming assays, pH 7.0, 37°C
0.0013
adriamycin
Homo sapiens
-
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0013
adriamycin
Homo sapiens
-
in A549 cells, pH 7.0, 37°C
0.0101
adriamycin
Homo sapiens
-
in CCD-18Co cells, pH 7.0, 37°C
0.0246
adriamycin
Homo sapiens
-
in HCT-15 cells, pH 7.0, 37°C
0.0246
adriamycin
Homo sapiens
-
in HT-1 197 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0246
adriamycin
Homo sapiens
-
sulforhodamine B, cytotoxic effects of 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid on the HCT-15 cell line by the sulforhodamine B (SRB) and colony forming assays, pH 7.0, 37°C
0.006
neomycin
Homo sapiens
-
isoform PLCdelta1, at pH 7.3 and 25°C
0.011
neomycin
Homo sapiens
-
isoform PLCbeta1, at pH 7.3 and 25°C
0.024
neomycin
Homo sapiens
-
isoform PLCgamma1, at pH 7.3 and 25°C
0.4
spermine
Homo sapiens
-
isoform PLCbeta1, at pH 7.3 and 25°C
1.7
spermine
Homo sapiens
-
isoform PLCdelta1, at pH 7.3 and 25°C
4
spermine
Homo sapiens
-
isoform PLCgamma1, at pH 7.3 and 25°C
additional information
additional information
Mus musculus
-
IC50 value is less than 0.1 microM for adriamycin in in P388 cells, pH 7.0, 37°C
-
additional information
additional information
Homo sapiens
-
IC50 value is less than 0.1 microM for adriamycin in MCF7 cells, pH 7.0, 37°C
-
additional information
additional information
Homo sapiens
-
the IC50 values for 3beta,7'-diacetoxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid, 3beta-hydroxyurs-12-en-28-oic 4-(E)-coumaroyl ester, 3beta,27-dihydroxyurs-12-en-28-oic acid, 3beta-4-(E)-coumaroyloxyurs-12-en-28-oic acid, and 4-(E)-coumaric acidare above 0.250 mM, pH 7.0, 37°C
-
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