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(2R)-2-[[(2S)-2-amino-3-cyclohexylpropanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]-2-methylpropanoic acid + H2O
?
-
-
-
-
?
(2R,3S)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]butanoic acid + H2O
?
-
-
-
-
?
(2R,3S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]butanoic acid + H2O
?
-
-
-
-
?
(2R,3S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]butanoic acid + H2O
?
-
-
-
-
?
(2S)-2-[[(2S)-2-amino-3-cyclohexylpropanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]-2-methylpropanoic acid + H2O
?
-
-
-
-
?
(2S)-2-[[(2S)-2-amino-3-cyclohexylpropanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]propanoic acid + H2O
?
-
-
-
-
?
(2S,3S)-2-[[(2S)-2-amino-3-biphenyl-4-ylpropanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]butanoic acid + H2O
?
-
-
-
-
?
(2S,3S)-2-[[(2S)-2-amino-3-cyclohexylpropanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]-4-methylpentanoic acid + H2O
?
-
-
-
-
?
(2S,3S)-2-[[(2S)-2-amino-3-cyclohexylpropanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]butanoic acid + H2O
?
-
-
-
-
?
(2S,3S)-2-[[(2S)-2-amino-3-naphthalen-2-ylpropanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]butanoic acid + H2O
?
-
-
-
-
?
(2S,3S)-2-[[(2S)-3-cyclohexyl-2-(dimethylamino)propanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]butanoic acid + H2O
?
-
-
-
-
?
(2S,3S)-2-[[(2S)-3-cyclohexyl-2-(formylamino)propanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]butanoic acid + H2O
?
-
-
-
-
?
(2S,3S)-2-[[(2S)-3-cyclohexyl-2-(methylamino)propanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]butanoic acid + H2O
?
-
-
-
-
?
Ala-Gln + H2O
Ala + Gln
-
100% activity
-
-
?
Ala-Leu + H2O
Ala + Leu
-
14.0% activity compared to Ala-Gln
-
-
?
Ala-Met + H2O
Ala + Met
-
-
-
-
?
Arg-Phe + H2O
Arg + Phe
-
6.3% activity compared to Ala-Gln
-
-
?
Asp-Phe + H2O
Asp + Phe
-
4.9% activity compared to Ala-Gln
-
-
?
B-type natriuretic peptide 1-32 + H2O
B-type natriuretic peptide 3-32 + ?
-
-
-
-
?
beta-lactam + H2O
?
-
-
-
-
?
D-Ala-D-Ala + H2O
D-Ala + D-Ala
-
assay at 30°C, pH 7.5
-
-
?
D-Ala-L-Ala + H2O
D-Ala + L-Ala
-
assay at 30°C, pH 7.5
-
-
?
gamma-L-glutamyl-L-cysteine + H2O
?
-
-
-
-
?
Gly-Ala + H2O
Gly + Ala
-
L-Ala and D-Ala
-
-
?
Gly-D-Leu + H2O
Gly + D-Leu
-
assay at 30°C, pH 7.5
-
-
?
Gly-D-Phe + H2O
Gly + D-Phe
Gly-Phe + H2O
Gly + Phe
-
-
-
-
?
Gly-Trp + H2O
Gly + Trp
-
-
-
-
?
Gly-Val + H2O
Gly + Val
-
-
-
-
?
glycyldehydrophenylalanine + H2O
?
Hemoglobin + H2O
?
-
-
-
-
?
L-Ala-D-Ala + H2O
L-Ala + D-Ala
-
assay at 30°C, pH 7.5
-
-
?
L-Ala-Gly + H2O
L-Ala + Gly
L-Ala-L-Ala + H2O
L-Ala + L-Ala
-
assay at 30°C, pH 7.5
-
-
?
L-Ala-L-Arg + H2O
L-Ala + L-Arg
-
assay at 30°C, pH 7.5
-
-
?
L-Ala-L-Asp + H2O
L-Ala + L-Asp
-
assay at 30°C, pH 7.5
-
-
?
L-Ala-L-Gln + H2O
L-Ala + L-Gln
-
assay at 30°C, pH 7.5
-
-
?
L-Ala-L-Glu + H2O
L-Ala + L-Glu
-
assay at 30°C, pH 7.5
-
-
?
L-Ala-L-His + H2O
L-Ala + L-His
-
assay at 30°C, pH 7.5
-
-
?
L-Ala-L-Lys + H2O
L-Ala + L-Lys
-
assay at 30°C, pH 7.5
-
-
?
L-Arg-D-Asp + H2O
L-Arg + D-Asp
-
assay at 30°C, pH 7.5
-
-
?
L-Arg-Gly + H2O
L-Arg + Gly
-
assay at 30°C, pH 7.5
-
-
?
L-Arg-L-Asp + H2O
L-Arg + L-Asp
-
assay at 30°C, pH 7.5
-
-
?
L-Asn-D-Glu + H2O
L-Asn + D-Glu
-
assay at 30°C, pH 7.5
-
-
?
L-Cys-Gly + H2O
?
-
-
-
-
?
L-cysteinylglycine + H2O
?
-
-
-
-
?
L-cystinyl-bis-Gly + H2O
L-Cys + Gly-Gly
L-cystinyl-bis-glycine + H2O
?
L-cystinyl-bis-glycine + H2O
L-Cys + Gly-Gly
-
-
-
-
?
L-Leu-D-Ala + H2O
L-Leu + D-Ala
-
assay at 30°C, pH 7.5
-
-
?
L-Leu-D-Glu + H2O
L-Leu + D-Glu
-
assay at 30°C, pH 7.5
-
-
?
L-Leu-D-Leu + H2O
L-Leu + D-Leu
-
assay at 30°C, pH 7.5
-
-
?
L-Leu-D-Ser + H2O
L-Leu + D-Ser
-
assay at 30°C, pH 7.5
-
-
?
L-Leu-L-Asp + H2O
L-Leu + L-Asp
-
assay at 30°C, pH 7.5
-
-
?
L-Leu-L-Leu + H2O
L-Leu + L-Leu
L-Met-D-Glu + H2O
L-Met + D-Glu
-
assay at 30°C, pH 7.5
-
-
?
L-Met-D-Leu + H2O
L-Met + D-Leu
-
assay at 30°C, pH 7.5
-
-
?
L-Met-L-Leu + H2O
L-Met + L-Leu
-
assay at 30°C, pH 7.5
-
-
?
L-Ser-Gly + H2O
L-Ser + Gly
-
-
-
-
?
L-Tyr-D-Leu + H2O
L-Tyr + D-Leu
-
assay at 30°C, pH 7.5
-
-
?
Leu-Phe + H2O
Leu + Phe
-
12.5% activity compared to Ala-Gln
-
-
?
Leu-Trp + H2O
Leu + Trp
-
10.2% activity compared to Ala-Gln
-
-
?
leukotriene D4 + H2O
leukotriene E4
-
-
-
?
Lys-Gly + H2O
Lys + Gly
-
-
-
-
?
N-acylated carbapenems + H2O
?
N-formimidoyl thienamycin + H2O
?
-
-
-
-
?
N-formimidoyl thienamycin derivative MK0787 + H2O
?
N-[([(1S,2R)-2-[(3-cyclohexyl-L-alanyl)amino]-3-hydroxy-1-methylpropyl]oxy)carbonyl]-2'-deoxy-2'-methylidenecytidine + H2O
?
-
-
-
-
?
N-[([(1S,2S)-2-[(3-cyclohexyl-L-alanyl)amino]-1,4-dimethyl-3-oxopentyl]oxy)carbonyl]-2'-deoxy-2'-methylidenecytidine + H2O
?
-
-
-
-
?
nonbasic N-acylated thienamycin + H2O
?
Phe-Ala + H2O
Phe + Ala
-
6.7% activity compared to Ala-Gln
-
-
?
Phe-Tyr + H2O
Phe + Tyr
-
-
-
-
?
pro-B-type natriuretic peptide 1-108 + H2O
pro-B-type natriuretic peptide 3-108 + ?
-
-
-
-
?
S-1-menaphthyl-L-Cys-Gly + H2O
S-1-menaphthyl-L-Cys + Gly
-
-
-
-
?
S-2,4-dinitrophenyl-L-Cys-Gly + H2O
2,4-dinitrophenol + L-Cys-Gly
-
-
-
-
?
S-4-nitrobenzyl-L-Cys-Gly + H2O
4-nitrobenzyl alcohol + L-Cys-Gly
-
-
-
-
?
S-N-ethylmaleimide-L-cysteinyl-glycine + H2O
?
-
-
-
-
?
Trp-Gly + H2O
Trp + Gly
-
-
-
-
?
Tyr-Leu + H2O
Tyr + Leu
-
9.5% activity compared to Ala-Gln
-
-
?
Tyr-Phe + H2O
Tyr + Phe
-
3.8% activity compared to Ala-Gln
-
-
?
Val-Gly + H2O
Val + Gly
-
-
-
-
?
additional information
?
-
Ala-Ala + H2O
Ala + Ala
-
62.5% activity compared to Ala-Gln
-
-
?
Ala-Ala + H2O
Ala + Ala
-
62.5% activity compared to Ala-Gln
-
-
?
Ala-Ala + H2O
Ala + Ala
-
-
-
-
?
Ala-Ala + H2O
Ala + Ala
-
-
-
-
?
Ala-Gly + H2O
Ala + Gly
-
68.9% activity compared to Ala-Gln
-
-
?
Ala-Gly + H2O
Ala + Gly
-
68.9% activity compared to Ala-Gln
-
-
?
Ala-Phe + H2O
Ala + Phe
-
14.0% activity compared to Ala-Gln
-
-
?
Ala-Phe + H2O
Ala + Phe
-
14.0% activity compared to Ala-Gln
-
-
?
Gly-D-Phe + H2O
Gly + D-Phe
-
-
-
-
?
Gly-D-Phe + H2O
Gly + D-Phe
-
-
-
?
Gly-D-Phe + H2O
Gly + D-Phe
-
-
-
-
?
Gly-Gly + H2O
Gly + Gly
-
-
-
-
?
Gly-Gly + H2O
Gly + Gly
-
-
-
-
?
Gly-Gly + H2O
Gly + Gly
-
-
-
-
?
Gly-Leu + H2O
Gly + Leu
-
-
-
-
?
Gly-Leu + H2O
Gly + Leu
-
best substrate
-
-
?
glycyldehydrophenylalanine + H2O
?
-
-
-
-
?
glycyldehydrophenylalanine + H2O
?
-
-
-
-
?
L-Ala-Gly + H2O
L-Ala + Gly
-
-
-
-
?
L-Ala-Gly + H2O
L-Ala + Gly
-
-
-
-
?
L-cystinyl-bis-Gly + H2O
L-Cys + Gly-Gly
-
-
-
-
?
L-cystinyl-bis-Gly + H2O
L-Cys + Gly-Gly
-
-
-
-
?
L-cystinyl-bis-glycine + H2O
?
-
-
-
-
?
L-cystinyl-bis-glycine + H2O
?
-
membrane-bound dipeptidase-2 cleaves leukotriene D4 but not cystinyl-bis-glycine while membrane-bound dipeptidase-3 cleaves cystinyl-bis-glycine but not LTD4
-
-
?
L-cystinyl-bis-glycine + H2O
?
-
-
-
-
?
L-Leu-L-Leu + H2O
L-Leu + L-Leu
-
-
-
-
?
L-Leu-L-Leu + H2O
L-Leu + L-Leu
-
assay at 30°C, pH 7.5
-
-
?
Leu-Gly + H2O
Leu + Gly
-
-
-
-
?
Leu-Gly + H2O
Leu + Gly
-
-
-
-
?
Leu-Leu + H2O
Leu + Leu
-
71% activity compared to Ala-Gln
-
-
?
Leu-Leu + H2O
Leu + Leu
-
-
-
-
?
Leu-Leu + H2O
Leu + Leu
-
-
-
-
?
Leu-Leu + H2O
Leu + Leu
-
-
-
-
?
leukotriene D4 + H2O
?
-
membrane-bound dipeptidase-2 cleaves leukotriene D4 but not cystinyl-bis-glycine while membrane-bound dipeptidase-3 cleaves cystinyl-bis-glycine but not LTD4
-
-
?
leukotriene D4 + H2O
?
-
the enzyme is involved in the reanal metabolism of glutathione and its conjugates such as leukotriene
-
-
?
Met-Met + H2O
Met + Met
-
-
-
-
?
Met-Met + H2O
Met + Met
-
-
-
-
?
N-acylated carbapenems + H2O
?
-
-
-
-
?
N-acylated carbapenems + H2O
?
-
-
-
-
?
N-formimidoyl thienamycin derivative MK0787 + H2O
?
-
hydrolysis of the beta-lactam ring
-
-
?
N-formimidoyl thienamycin derivative MK0787 + H2O
?
-
hydrolysis of the beta-lactam ring
-
-
?
nonbasic N-acylated thienamycin + H2O
?
-
-
-
-
?
nonbasic N-acylated thienamycin + H2O
?
-
-
-
-
?
Phe-Gly + H2O
Phe + Gly
-
74.1% activity compared to Ala-Gln
-
-
?
Phe-Gly + H2O
Phe + Gly
-
74.1% activity compared to Ala-Gln
-
-
?
Phe-Gly + H2O
Phe + Gly
-
-
-
-
?
thienamycin + H2O
?
-
hydrolysis of the beta-lactam ring
-
-
?
thienamycin + H2O
?
-
hydrolysis of the beta-lactam ring
-
-
?
additional information
?
-
-
low activity toward dipeptides containing aromatic amino acids except for Phe-Gly, does not hydrolyze Leu-Asp, Phe-Phe, or N- or C-terminus-blocked dipeptides (N-carbobenzyloxy-Phe-Gly, N-carbobenzyloxy-Ala-Leu, or Leu-Leu-amide), does not hydrolyze tri-, tetra-, or pentapeptides or p-nitroanilide derivatives of dipeptides and peptides
-
-
?
additional information
?
-
-
low activity toward dipeptides containing aromatic amino acids except for Phe-Gly, does not hydrolyze Leu-Asp, Phe-Phe, or N- or C-terminus-blocked dipeptides (N-carbobenzyloxy-Phe-Gly, N-carbobenzyloxy-Ala-Leu, or Leu-Leu-amide), does not hydrolyze tri-, tetra-, or pentapeptides or p-nitroanilide derivatives of dipeptides and peptides
-
-
?
additional information
?
-
-
the enzyme also has beta-lactamase activity
-
-
?
additional information
?
-
-
enzyme prefers substrates with bulky, hydrophobic group of the dipeptide located at the N-terminal position
-
-
?
additional information
?
-
-
the enzyme is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics
-
-
?
additional information
?
-
-
the enzyme might play an important role in the metabolism of glutathione and leukotriene
-
-
?
additional information
?
-
-
does not hydrolyze gamma-L-glutamyl-p-nitroanilide
-
-
?
additional information
?
-
-
no hydrolysis of L-Asp-Gly
-
-
?
additional information
?
-
-
no hydrolysis of proline-containing peptides
-
-
?
additional information
?
-
-
no hydrolysis of glutathione
-
-
?
additional information
?
-
-
no hydrolysis of L-Val-Gly
-
-
?
additional information
?
-
-
no hydrolysis of D-Ala-Gly
-
-
?
additional information
?
-
-
broad specificity
-
-
?
additional information
?
-
-
no esterase activity
-
-
?
additional information
?
-
-
no hydrolysis of proteins
-
-
?
additional information
?
-
-
no hydrolysis of tripeptides
-
-
?
additional information
?
-
-
no hydrolysis of leucinamide
-
-
?
additional information
?
-
-
no hydrolysis of leucinamide
-
-
?
additional information
?
-
-
no hydrolysis of D-leucylglycine
-
-
?
additional information
?
-
-
no hydrolysis of L-alanyl-glycylglycine
-
-
?
additional information
?
-
-
no hydrolysis of L-serylglycylglycine
-
-
?
additional information
?
-
-
no hydrolysis of L-leucylglycylglycine
-
-
?
additional information
?
-
-
the enzyme also has beta-lactamase activity
-
-
?
additional information
?
-
-
no reaction with leucinamide
-
-
?
additional information
?
-
-
no reaction with leucinamide
-
-
?
additional information
?
-
-
requires the N-terminal amino acid of the dipeptide in the L-configuration
-
-
?
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Acute Kidney Injury
Nitric oxide inhibits the shedding of the glycosylphosphatidylinositol-anchored dipeptidase from porcine renal proximal tubules.
Carcinogenesis
CNDP2 Acts as an Activator for Human Ovarian Cancer Growth and Metastasis via the PI3K/AKT Pathway.
Carcinoma
Chronic colitis induces expression of ?-defensins in murine intestinal epithelial cells.
Colorectal Neoplasms
Synthesis and evaluation of aminophosphinic acid derivatives as inhibitors of renal dipeptidase.
Dehydration
Effects of water deprivation on drug pharmacokinetics: correlation between drug metabolism and hepatic CYP isozymes.
Gram-Negative Bacterial Infections
Murine beta-defensin-3 is an inducible peptide with limited tissue expression and broad-spectrum antimicrobial activity.
Infections
?-Defensins Coordinate In Vivo to Inhibit Bacterial Infections of the Trachea.
Infections
Dicationic dithiocarbamate carbapenems with anti-MRSA activity.
Infections
Enhanced expression of murine beta-defensins (MBD-1, -2,- 3, and -4) in upper and lower airway mucosa of influenza virus infected mice.
Infections
Expression and antimicrobial function of beta-defensin 1 in the lower urinary tract.
Infections
Expression of mouse beta-defensin-3 in MDCK cells and its anti-influenza-virus activity.
Infections
Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma.
Infections
Murine beta-defensin-3 is an inducible peptide with limited tissue expression and broad-spectrum antimicrobial activity.
Kidney Failure, Chronic
Behaviour of urinary dipeptidase in patients with chronic renal failure.
Lung Diseases
Mouse beta defensin-1 is a functional homolog of human beta defensin-1.
Malnutrition
Undernutrition and intestinal dipeptide hydrolase activity in the rat.
membrane dipeptidase deficiency
Expression and antimicrobial function of beta-defensin 1 in the lower urinary tract.
Meningitis
Pharmacokinetics of N-formimidoyl thienamycin and influence of a renal dipeptidase inhibitor in experimental meningitis.
Mucopolysaccharidoses
Mucopolysaccharidosis IVA: submicroscopic deletion of 16q24.3 and a novel R386C mutation of N-acetylgalactosamine-6-sulfate sulfatase gene in a classical Morquio disease.
Muscle Cramp
Interleukin-17A (IL-17A) and IL-17F Are Critical for Antimicrobial Peptide Production and Clearance of Staphylococcus aureus Nasal Colonization.
Neoplasm Metastasis
CNDP2 Acts as an Activator for Human Ovarian Cancer Growth and Metastasis via the PI3K/AKT Pathway.
Neoplasms
Administration of vitamin D3 improves antimetastatic efficacy of cancer vaccine therapy of Lewis lung carcinoma.
Neoplasms
CNDP2 Acts as an Activator for Human Ovarian Cancer Growth and Metastasis via the PI3K/AKT Pathway.
Neoplasms
Design and synthesis of novel prodrugs of 2'-deoxy-2'-methylidenecytidine activated by membrane dipeptidase overexpressed in tumor tissues.
Neoplasms
Interleukin-1 receptor-1-deficient mice show attenuated production of ocular surface inflammatory cytokines in experimental dry eye.
Neoplasms
Mechanical and Metabolic Injury to the Skin Barrier Leads to Increased Expression of Murine ?-Defensin-1, -3, and -14.
Neoplasms
Probing the structural and molecular diversity of tumor vasculature.
Ovarian Neoplasms
CNDP2 Acts as an Activator for Human Ovarian Cancer Growth and Metastasis via the PI3K/AKT Pathway.
Peritonitis
Murine beta-defensin-3 is an inducible peptide with limited tissue expression and broad-spectrum antimicrobial activity.
Whooping Cough
Insulin stimulates the release of a subset of GPI-anchored proteins in a G-protein independent manner.
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