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EC Tree
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Release of a C-terminal residue other than proline, by preferential cleavage of a prolyl bond
Synonyms
prolylcarboxypeptidase, carboxypeptidase p, prolyl-carboxypeptidase,
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exo-type carboxypeptidase P
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membrane Pro-Xaa carboxypeptidase
Microsomal carboxypeptidase
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prolyl-carboxypeptidase
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prolylcarboxypeptidase
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Carboxypeptidase P
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membrane Pro-Xaa carboxypeptidase
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membrane Pro-Xaa carboxypeptidase
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Release of a C-terminal residue other than proline, by preferential cleavage of a prolyl bond
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hydrolysis of peptide bond
hydrolysis of peptide bond
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hydrolysis of peptide bond
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hydrolysis of peptide bond
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Ala-Ala-Ala-Ala + H2O
Ala-Ala-Ala + Ala
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?
Benzyloxycarbonyl-Ala-Phe + H2O
Benzyloxycarbonyl-Ala + Phe
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?
Benzyloxycarbonyl-Gly-Pro-Ala + H2O
Benzyloxycarbonyl-Gly-Pro- + Ala
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?
Benzyloxycarbonyl-Gly-Pro-Gly-Gly-Pro-Ala + H2O
Benzyloxycarbonyl-Gly-Pro-Gly-Gly-Pro + Ala
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?
Benzyloxycarbonyl-Leu-Gly-Pro-Ala + H2O
Benzyloxycarbonyl-Leu-Gly-Pro + Ala
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?
Benzyloxycarbonyl-Pro-Ala + H2O
Benzyloxycarbonyl-Pro + Ala
Benzyloxycarbonyl-Pro-Gly + H2O
Benzyloxycarbonyl-Pro + Gly
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?
Benzyloxycarbonyl-Pro-Met + H2O
Benzyloxycarbonyl-Pro + Met
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?
Benzyloxycarbonyl-Pro-Phe + H2O
Benzyloxycarbonyl-Pro + Phe
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?
hirudin variant 3 + H2O
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HPLC-ESI-ITMS is used as atool to confirm the C-terminal sequence of HV3, the degradation of the C-terminal of HV3 is studied using carboxypeptidase P und Y
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Myoglobin + H2O
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prekallikrein + H2O
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the potential PRCP cleavage site on prekallikrein is identified based on molecular modelling
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Val-Ala-Ala-Phe + H2O
Val-Ala-Ala + Phe
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?
additional information
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peptides free of proline are also cleaved, but normally at a rather low rate
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Benzyloxycarbonyl-Pro-Ala + H2O
Benzyloxycarbonyl-Pro + Ala
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?
Benzyloxycarbonyl-Pro-Ala + H2O
Benzyloxycarbonyl-Pro + Ala
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?
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Zn
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each of the two subunits contains one Zn atom, ZnSO4, 0.5 mM, limited activation in absence of MnCl2, strong inhibition above 0.5 mM
Mn2+
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activates
Mn2+
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MnCl2, 1 mM, is necessary for maximal activity
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Zn2+
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0.5 mM activates, inhibition above
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dexamethasone
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up-regulation the gene expression subsequent to 48 h treatment of SH-SY5Y cells with 30 nM dexamethasone plus 1 nM [D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin acetate
[D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin acetate
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up-regulation the gene expression subsequent to 48 h treatment of SH-SY5Y cells with 30 nM dexamethasone plus 1 nM [D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin acetate
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Angioedema
Lisinopril-Induced Angioedema in a Patient with Plasma Prekallikrein Deficiency.
Breast Neoplasms
Prolylcarboxypeptidase regulates proliferation, autophagy, and resistance to 4-hydroxytamoxifen-induced cytotoxicity in estrogen receptor-positive breast cancer cells.
Breast Neoplasms
The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT.
Diabetes Mellitus
Plasma prolylcarboxypeptidase (angiotensinase C) is increased in obesity and diabetes mellitus and related to cardiovascular dysfunction.
Essential Hypertension
Association of polymorphisms in prolylcarboxypeptidase and chymase genes with essential hypertension in the Chinese Han population.
Essential Hypertension
Genetic association study of prolylcarboxypeptidase polymorphisms with susceptibility to essential hypertension in the Yi minority of China: A case-control study based on an isolated population.
Hypertension
Expression, purification and crystallization of human prolylcarboxypeptidase.
Hypertension
Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis.
Hypertension
Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia.
Hypertension
Prolylcarboxypeptidase promotes angiogenesis and vascular repair.
membrane pro-xaa carboxypeptidase deficiency
Prolylcarboxypeptidase deficiency is associated with increased blood pressure, glomerular lesions, and cardiac dysfunction independent of altered circulating and cardiac angiotensin II.
Obesity
Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity.
Obesity
Expression, purification and crystallization of human prolylcarboxypeptidase.
Obesity
Plasma prolylcarboxypeptidase (angiotensinase C) is increased in obesity and diabetes mellitus and related to cardiovascular dysfunction.
Obesity
Prolylcarboxypeptidase (PRCP) as a new target for obesity treatment.
Obesity
Prolylcarboxypeptidase gene expression in the heart and kidney: Effects of obesity and diabetes.
Pre-Eclampsia
Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia.
Thrombosis
Influence of a novel inhibitor (UM8190) of prolylcarboxypeptidase (PRCP) on appetite and thrombosis.
Thrombosis
Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis.
Thrombosis
Prolylcarboxypeptidase promotes angiogenesis and vascular repair.
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4.1
Benzyloxycarbonyl-Pro-Met
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0.1
myoglobin
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Michaelis-Menten kinetics in the bulk solution
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0.13
myoglobin
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transient kinetics CPP on the QCM
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20.5
Benzyloxycarbonyl-Pro-Met
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0.3
myoglobin
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Michaelis-Menten kinetics in the bulk solution
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1.1
myoglobin
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transient kinetics CPP on the QCM
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additional information
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additional information
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7.8
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in presence of 1 mM MnCl2
3.7
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enzyme reaction on the QCM plate
3.7
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hydrolysis of myoglobin in bulk solution
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2 - 6
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enzyme reaction on the QCM plate
2.5 - 5
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hydrolysis of myoglobin in bulk solution
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25
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enzyme reaction on the QCM plate
25
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hydrolysis of myoglobin in bulk solution
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brenda
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brenda
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brenda
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brenda
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brenda
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neuroblastoma cell
brenda
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brenda
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brenda
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brenda
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135000
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2 * 135000, pig, SDS-PAGE
240000
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pig, gel filtration
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dimer
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2 * 135000, pig, SDS-PAGE
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glycoprotein
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0.332 mg carbohydrate per mg of protein including 23% mannose, 29% galactose, 30% N-acetylglucosamine, 7% glucose and 11% uncharacterized sugar
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medicine
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results from the study could provide new therapeutic opportunity for the treatment of infection
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Dehm, P.; Nordwig, A.
The cleavage of prolyl peptides by kidney peptidases. Isolation of a microsomal carboxypeptidase from swine kidney
Eur. J. Biochem.
17
372-377
1970
Sus scrofa
brenda
Hedeager-Sorensen, S.; Kenny, A.J.
Proteins of the kidney microvillar membrane. Purification and properties of carboxypeptidase P from pig kidneys
Biochem. J.
229
251-257
1985
Sus scrofa
brenda
Booth, A.G.; Hubbard, L.M.L.; Kenny, A.J.
Proteins of the kidney microvillar membrane. Immunoelectrophoretic analysis of the membrane hydrolases: identification and resolution of the detergent- and proteinase-solubilized forms
Biochem. J.
179
397-405
1979
Sus scrofa
brenda
Furusawa, H.; Takano, H.; Okahata, Y.
Transient kinetic studies of pH-dependent hydrolyses by exo-type carboxypeptidase P on a 27-MHz quartz crystal microbalance
Anal. Chem.
80
1005-1011
2008
Penicillium janthinellum
brenda
Perkins, R.; Ngo, M.D.; Mahdi, F.; Shariat-Madar, Z.
Identification of lipopolysaccharide binding site on high molecular weight kininogen
Biochem. Biophys. Res. Commun.
366
938-943
2008
Homo sapiens
brenda
Ward, G.R.; Franklin, S.O.; Gerald, T.M.; Dempsey, K.T.; Clodfelter, D.E.; Krissinger, D.J.; Patel, K.M.; Vrana, K.E.; Howlett, A.C.
Glucocorticoids plus opioids up-regulate genes that influence neuronal function
Cell. Mol. Neurobiol.
27
651-660
2007
Homo sapiens
brenda
Huang, X.D.; Tong, W.W.; Fan, X.L.; Li, Z.H.
Application of HPLC-ESI-ITMS in the quality control of carboxyterminal sequence confirmation for the recombinant DNA product Hirudin Variant 3
J. Pharm. Biomed. Anal.
43
533-539
2007
Penicillium janthinellum
brenda
Furusawa, H.; Takano, H.; Okahata, Y.
Transient kinetic studies of protein hydrolyses by endo- and exo-proteases on a 27 MHz quartz-crystal microbalance
Org. Biomol. Chem.
6
727-731
2008
Penicillium janthinellum
brenda
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