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(3-Me-His2)thyrotropin-releasing hormone + H2O
?
-
-
-
-
?
acid-thyroliberin + H2O
?
-
-
-
-
?
L-5-oxoprolyl 2-naphthylamide + H2O
2-naphthylamine + 5-oxoproline
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + 2-naphthylamine
-
-
-
?
L-pyroglutamyl-L-Tyr-L-Pro-NH2 + H2O
L-pyroglutamate + L-Tyr-L-Pro-NH2
-
-
-
-
?
luliberin N-terminal tripeptide + H2O
?
-
pyroglutamyl-His-Trp
-
-
?
pyroglutamyl-7-amido-4-methylcoumarin + H2O
pyroglutamate + 7-amino-4-methylcoumarin
-
-
-
-
?
pyroglutamyl-Asn(N-benzyl)-ProNH2 + H2O
L-pyroglutamate + Asn(N-benzyl)-ProNH2
-
-
-
-
?
pyroglutamyl-Asn(N-methyl)-ProNH2 + H2O
L-pyroglutamate + Asn(N-methyl)-ProNH2
-
-
-
-
?
pyroglutamyl-His-Gly + H2O
pyroglutamate + His-Gly
-
slight
-
-
?
pyroglutamyl-His-Pro-7-amido-4-methylcoumarin + H2O
pyroglutamate + His-Pro-7-amido-4-methylcoumarin
pyroglutamyl-His-Pro-NH2 + H2O
pyroglutamate + His-Pro-NH2
-
-
-
-
?
pyroglutamyl-His-Pro-OH + H2O
pyroglutamate + His-Pro-OH
-
-
-
-
?
pyroglutamyl-His-tripeptidyl naphthylamides + H2O
pyroglutamate + His-tripeptidyl naphthylamides
-
-
-
-
?
pyroglutamyl-histidyl-prolyl-7-amido-4-methylcoumarin + H2O
pyroglutamic acid + histidyl-prolyl-7-amido-4-methylcoumarin
-
-
-
-
?
pyroglutamyl-Phe-Pro-NH2 + H2O
pyroglutamate + Phe-Pro-NH2
-
-
-
-
?
pyroglutamyl-Phe-Pro-OH + H2O
pyroglutamate + Phe-Pro-OH
-
-
-
-
?
pyroglutamyl-thienylalanyl-Pro-NH2 + H2O
pyroglutamate + thienylalanyl-Pro-NH2
-
-
-
-
?
pyroglutamyl-Tyr-Pro-OH + H2O
pyroglutamate + Tyr-Pro-OH
-
-
-
-
?
thyroliberin + H2O
pyroglutamic acid + His-Pro-NH2
thyrotrophin-releasing hormone + H2O
L-pyroglutamate + ?
-
-
-
?
thyrotropin releasing hormone + H2O
?
thyrotropin releasing hormone-beta-naphthylamine + H2O
?
-
substrate activity assay
-
-
?
thyrotropin-releasing hormone + H2O
?
-
-
-
-
?
thyrotropin-releasing hormone-beta-naphthylamide + H2O
?
-
essential role of Glu408 within the exopeptidase motif for aminopeptidase activity. Ser269 and Lys463 are implicated in the generation of omegapeptidase specificity. Lys463 creates a putative salt bridge with Glu408
-
-
?
TRH-like peptide + H2O
L-pyroglutamate + ?
-
-
-
?
additional information
?
-
L-5-oxoprolyl 2-naphthylamide + H2O
2-naphthylamine + 5-oxoproline
-
very poor substrate
-
?
L-5-oxoprolyl 2-naphthylamide + H2O
2-naphthylamine + 5-oxoproline
-
very poor substrate
-
?
pyroglutamyl-His-Pro-7-amido-4-methylcoumarin + H2O
pyroglutamate + His-Pro-7-amido-4-methylcoumarin
-
-
-
-
?
pyroglutamyl-His-Pro-7-amido-4-methylcoumarin + H2O
pyroglutamate + His-Pro-7-amido-4-methylcoumarin
-
-
-
-
?
thyroliberin + H2O
?
-
thyroliberin may act as neurotransmitter
-
-
?
thyroliberin + H2O
?
-
may control the biological activity of the neuronally released thyrotropin
-
-
?
thyroliberin + H2O
?
-
involved in the conversion of thyrotropin-releasing hormone into histidyl-proline diketopiperazine
-
-
?
thyroliberin + H2O
pyroglutamic acid + His-Pro-NH2
-
-
-
-
?
thyroliberin + H2O
pyroglutamic acid + His-Pro-NH2
-
-
-
-
?
thyroliberin + H2O
pyroglutamic acid + His-Pro-NH2
-
-
-
-
?
thyroliberin + H2O
pyroglutamic acid + His-Pro-NH2
-
i.e. pyroglutamyl-His-Pro-NH2, thyrotropin-releasing hormone
-
-
?
thyroliberin + H2O
pyroglutamic acid + His-Pro-NH2
-
i.e. pyroglutamyl-His-Pro-NH2, thyrotropin-releasing hormone
pyroglutamic acid + histidyl-proline diketopiperazine
?
thyroliberin + H2O
pyroglutamic acid + His-Pro-NH2
-
-
-
-
?
thyroliberin + H2O
pyroglutamic acid + His-Pro-NH2
-
rapid stereospecific cleavage only of the pyroglutamyl-histidine bond of thyroliberin and closely related peptides
-
?
thyroliberin + H2O
pyroglutamic acid + His-Pro-NH2
-
cleavage at the pyroglutamyl-histidine bond
-
-
?
thyroliberin + H2O
pyroglutamic acid + His-Pro-NH2
-
i.e. pyroglutamyl-His-Pro-NH2, thyrotropin-releasing hormone
-
-
?
thyrotropin releasing hormone + H2O
?
-
-
-
-
?
thyrotropin releasing hormone + H2O
?
-
-
-
-
?
additional information
?
-
-
overview: substrate specificity
-
-
?
additional information
?
-
-
no hydrolysis of pyroglutamyl peptides containing more than three amino acids
-
-
?
additional information
?
-
-
specific for tripeptides, tripeptide-amides, and tetrapeptides possessing the N-terminal sequence pyroglutamyl-His and as such is specific for thyrotropin releasing hormone or only very closely related peptides
-
-
?
additional information
?
-
-
no hydrolysis of dipeptides containing N-terminal pyroglutamic acid
-
-
?
additional information
?
-
-
no hydrolysis of pyroglutamyl-His decapeptide LHRH
-
-
?
additional information
?
-
-
no hydrolysis of pyroglutamyl-His
-
-
?
additional information
?
-
-
no hydrolysis of Phe3-thyrotropin
-
-
?
additional information
?
-
-
no hydrolysis of ring opened Glu1-thyrotropin
-
-
?
additional information
?
-
-
no hydrolysis of pyroglutamyl-His-Pro-Ala naphthylamide
-
-
?
additional information
?
-
-
no hydrolysis of pyroglutamyl-His bond of the dipeptide pyroglutamyl-His naphthylamide
-
-
?
additional information
?
-
-
detection of a RNA species derived from an alternative processing at the exon 14intron 14 boundary. The alternatively processed RNA encodes a shorter version of PPII (PPII*), lacking part of the C-terminal domain. PPII* is expressed in COS-7 (or C6 glioma) cells but it does not exhibit any PPII activity. Co-transfection of PPII and increasing amounts of PPII* expression vectors results in a dose-dependent reduction in PPII activity and the formation of covalent PPIIPPII* heterodimers. PPII* is therefore a powerful dominant-negative isoform of PPII, and heterodimerization may be its mechanism of action. Natural expression of shortened versions of M1 aminopeptidases may constitute a new mode of regulation of their activity
-
-
?
additional information
?
-
-
hydrolyzing of substrates with the general structure pGlu-X-Y, X being a moderately bulky and uncharged residue and Y, either Pro, Ala, Trp, Pro-Gly, ProNH2, Pro-beta-naphthylamine, or Pro-7-amino-4-methyl coumarin
-
-
?
additional information
?
-
-
moderately bulky, uncharged P1' residues preferentially bind to the enzyme
-
-
?
additional information
?
-
-
no hydrolysis of pyroglutamyl-His
-
-
?
additional information
?
-
-
no hydrolysis of pyroglutamyl-Ala or pyroglutamyl 2-naphthylamide (known substrates of the serum enzyme)
-
-
?
additional information
?
-
-
no hydrolysis of neurotensin
-
-
?
additional information
?
-
-
no hydrolysis of thyroliberin analogues LLD-thyroliberin, pyroglutamyl-His-Pro-NHCH3, pyroglutamyl-His-Pro-Gly-NHCH3 or pyroglutamyl-Phe-Pro-NH2
-
-
?
additional information
?
-
-
no hydrolysis of luliberin
-
-
?
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1,3-benzodioxol-5-amine
-
-
1,7-phenanthroline
-
10 mM, 67% inhibition
2-Aminobenzyl alcohol
-
-
3-(trifluoromethoxy)aniline
-
-
3-phenyl-1-propylamine
-
-
4,7-phenanthroline
-
10 mM, 56% inhibition
4-(2-aminoethyl)-benzenesulfonylfluoride
-
66% inhibition at 1 mM, 97% inhibition at 10 mM
4-(trifluoromethyl)aniline
-
-
4-amino-N-methylphthalamide
-
-
5,6,7,8-tetrahydro-1-naphthylamine
-
-
5-amino-2-chloropyridine
-
-
5-amino-2-methoxyphenol
-
-
5-chloro-2-methoxyaniline
-
-
5-oxoproline
-
product inhibition at high concentration
6-amino-1,3-dihydroisobenzofuran-1-one
-
-
6-amino-2-mercaptobenzothiazole
-
-
6-amino-3,4-benzocoumarin
-
-
7-amino-4-methylcoumarin
-
-
8-hydroxyquinoline
-
10 mM, 68% inhibition
CDTA
-
10 mM, 10% inhibition
Glp-Asn-Pro-D-Tyr-D-Trp-7-amido-4-methyl-coumarin
-
-
Glp-Asn-Pro-D-Tyr-D-Trp-D-Trp-7-amido-4-methyl-coumarin
-
-
Glp-Asn-Pro-D-Tyr-D-TrpNH2
-
potent inhibitor of TRH-DE. Competetive, fully reversible and not time dependent inhibition
Glp-Asn-Pro-Tyr-Trp-7-amido-4-methyl-coumarin
-
-
Glp-Asn-Pro-Tyr-Trp-Trp-7-amido-4-methyl-coumarin
-
-
Glp-Asn-Pro-Tyr-TrpNH2
-
-
Glp-PSI[P(O)(OH)CH2]-His-Pro-NH2
Hermodice carunculata inhibitor
-
Hermodice carunculata peptidase inhibitor
-
HcPI
-
His-Pro-NH2
-
product inhibition at high concentration
L-pyroglutamyl-Asn-Pro-NH2
-
inhibition is fully reversible
Luteinizing hormone releasing hormone
-
-
NEM
-
10 mM, 22% inhibition
p-Glu-Asn-Pro-7-amido-4-methylcoumarin
-
Peptides containing N-terminal pyroglutamyl residues
-
-
-
puromycin
-
1 mM, 17% inhibition
pyroglutamyl-7-amido-4-methylcoumarin
-
-
pyroglutamyl-Asn(N-benzyl)-ProNH2
-
-
pyroglutamyl-Asn(N-hydroxyl)-ProNH2
-
-
pyroglutamyl-Asn(N-methyl)-ProNH2
-
-
pyroglutamyl-Asn(N-phenyl)-ProNH2
-
-
pyroglutamyl-Asn-Pro-7-amido-4-methyl coumarin
-
-
pyroglutamyl-Asn-Pro-7-amido-4-methylcoumarin
-
-
pyroglutamyl-Asn-Pro-NH2
-
-
pyroglutamyl-Asn-Pro-Ser-TyrNH2
-
-
pyroglutamyl-Asn-Pro-Trp-7-amido-4-methylcoumarin
-
-
pyroglutamyl-Asn-Pro-Trp-Trp-7-amido-4-methylcoumarin
-
-
pyroglutamyl-Asn-Pro-Trp-TyrNH2
-
-
pyroglutamyl-Asn-Pro-TrpNH2
-
-
pyroglutamyl-Asn-Pro-Tyr-Trp-7-amido-4-methylcoumarin
-
-
pyroglutamyl-Asn-Pro-Tyr-Trp-Trp-7-amido-4-methylcoumarin
-
-
pyroglutamyl-Asn-Pro-Tyr-Trp-TrpNH2
-
-
pyroglutamyl-Asn-Pro-Tyr-TrpNH2
-
-
pyroglutamyl-Asn-Pro-TyrNH2
-
-
pyroglutamyl-Asn-ProNH2
-
-
pyroglutamyl-Gln-Pro-NH2
-
-
pyroglutamyl-Gly-Pro-NH2
-
inhibition is fully reversible
pyroglutamyl-His-Gly-NH2
-
-
pyroglutamyl-His-Pro-7-amido-4-methylcoumarin
-
-
pyroglutamyl-His-Pro-Gly
-
-
pyroglutamyl-His-Pro-Gly-NH2
-
-
pyroglutamyl-His-Pro-NH2
-
-
pyroglutamyl-His-Trp-Ser-Tyr-Gly
-
-
pyroglutamyl-His-Trp-Ser-Tyr-Gly-Leu
-
-
pyroglutamyl-His-Trp-Ser-Tyr-Gly-Leu-Arg
-
-
pyroglutamyl-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly
-
-
pyroglutamyl-homoprolyl-Pro-NH2
-
-
pyroglutamyl-L-alpha-phenylglycyl-Pro-NH2
-
-
pyroglutamyl-Phe-Pro-NH2
-
-
pyroglutamyl-Trp-Pro-NH2
-
-
Thyroliberin analogues
-
LLD-thyroliberin, pyroglutamyl-His-Pro-NHCH3, pyroglutamyl-His-Pro-Gly-NHCH3, pyroglutamyl-Phe-Pro-NH2
-
Cd2+
-
50% inhibition at 0.1 mM CsSO4, 98% inhibition at 1 mM
CuSO4
-
0.1 mM
EDTA
-
10 mM, 29% inhibition
Glp-PSI[P(O)(OH)CH2]-His-Pro-NH2
-
phosphinic analogue of thyrotropin releasing hormone, ED50 170 nM
Glp-PSI[P(O)(OH)CH2]-His-Pro-NH2
-
phosphinic analogue of thyrotropin releasing hormone
Glp-PSI[P(O)(OH)CH2]-His-Pro-NH2
-
Hermodice carunculata inhibitor
-
-
-
Hermodice carunculata inhibitor
-
the inhibitor is found in Hermodice carunculata and purified, MW below 1000 Da, the inhibitor is not a peptide
-
Hg2+
-
1 mM HgSO4, 76% inhibition
Luliberin
-
inhibits hydrolysis of thyroliberin competitively
metal chelators
-
-
-
ZnSO4
-
1 mM ZnSO4, 61% inhibition
additional information
-
no inhibition by aspartyl protease inhibitors; no inhibition by cysteine protease inhibitors; no inhibition by serine protease inhibitors
-
additional information
-
no inhibition by bacitracin; no inhibition by puromycin
-
additional information
-
PPII inhibitory activity als detected in Phallusia nigra, Palythoa caribaeorum and Mycale microsigmatosa
-
additional information
-
expression of PPII is downregulated in amygdala of yoked rats (immersed in a tank with no platform or spatial cues) and rats trained to find a hidden platform in water after 5 min of day 1 and 5. In hippocampus, no significant variations are observed for PPII expression at any time
-
additional information
-
no inhibition by NEM; no inhibition by serine protease inhibitors; no inhition by 2-iodoacetamide
-
additional information
-
no inhibition by chlordiazepoxide; no inhibition by DTNB; no inhibition by NEM; no inhibition by pepstatin; no inhition by 2-iodoacetamide
-
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0.00124
1,3-benzodioxol-5-amine
-
-
0.02187
2-Aminobenzyl alcohol
-
-
0.00742
2-hydroxyaniline
-
-
0.00398
2-Phenylethylamine
-
-
0.00318
3,4-dimethoxyaniline
-
-
0.00085
3,5-dimethoxyaniline
-
-
0.00125
3-(trifluoromethoxy)aniline
-
-
0.00498
3-phenyl-1-propylamine
-
-
0.00097
4-(trifluoromethyl)aniline
-
-
0.0089
4-amino-N-methylphthalamide
-
-
0.00345
4-phenylbutylamine
-
-
0.01014
5,6,7,8-tetrahydro-1-naphthylamine
-
-
0.00163
5-amino-2-chloropyridine
-
-
0.00254
5-amino-2-methoxyphenol
-
-
0.01085
5-chloro-2-methoxyaniline
-
-
0.00278
6-amino-1,3-dihydroisobenzofuran-1-one
-
-
0.00362
6-amino-2-mercaptobenzothiazole
-
-
0.0019
6-amino-3,4-benzocoumarin
-
-
0.000047
7-amino-4-methylcoumarin
-
-
0.01529
benzyl alcohol
-
-
0.000096
Glp-Asn-Pro-D-Tyr-D-Trp-7-amido-4-methyl-coumarin
-
-
0.000029
Glp-Asn-Pro-D-Tyr-D-Trp-D-Trp-7-amido-4-methyl-coumarin
-
-
0.000151
Glp-Asn-Pro-D-Tyr-D-TrpNH2
-
-
0.000038
Glp-Asn-Pro-Tyr-Trp-7-amido-4-methyl-coumarin
-
-
0.000001
Glp-Asn-Pro-Tyr-Trp-Trp-7-amido-4-methyl-coumarin
-
-
0.00064
Glp-Asn-Pro-Tyr-TrpNH2
-
-
0.000051
Hermodice carunculata inhibitor
-
37°C
-
0.008
Luteinizing hormone releasing hormone
-
-
0.00167
m-phenethidine
-
-
0.08416
methyl alcohol
-
-
0.0996
pyroglutamyl-Asn(N-benzyl)-ProNH2
-
37°C, pH 7.5
0.115
pyroglutamyl-Asn(N-hydroxyl)-ProNH2
-
37°C, pH 7.5
0.103
pyroglutamyl-Asn(N-methyl)-ProNH2
-
37°C, pH 7.5
0.133
pyroglutamyl-Asn(N-phenyl)-ProNH2
-
37°C, pH 7.5
0.00097
pyroglutamyl-Asn-Pro-7-amido-4-methyl coumarin
-
pH 7.5, 37°C, hydrolysis of pyroglutamyl-His-Pro-7-amido-4-methylcoumarin
0.000458
pyroglutamyl-Asn-Pro-7-amido-4-methylcoumarin
-
-
0.0175
pyroglutamyl-Asn-Pro-NH2
-
pH 7.5, 37°C, hydrolysis of pyroglutamyl-His-Pro-7-amido-4-methylcoumarin
0.00811
pyroglutamyl-Asn-Pro-Ser-TyrNH2
-
-
0.000083
pyroglutamyl-Asn-Pro-Trp-7-amido-4-methylcoumarin
-
-
0.000072
pyroglutamyl-Asn-Pro-Trp-Trp-7-amido-4-methylcoumarin
-
-
0.00591
pyroglutamyl-Asn-Pro-Trp-TyrNH2
-
-
0.00517
pyroglutamyl-Asn-Pro-TrpNH2
-
-
0.000038
pyroglutamyl-Asn-Pro-Tyr-Trp-7-amido-4-methylcoumarin
-
-
0.000001
pyroglutamyl-Asn-Pro-Tyr-Trp-Trp-7-amido-4-methylcoumarin
-
-
0.000734
pyroglutamyl-Asn-Pro-Tyr-Trp-TrpNH2
-
-
0.000639
pyroglutamyl-Asn-Pro-Tyr-TrpNH2
-
-
0.0103
pyroglutamyl-Asn-Pro-TyrNH2
-
-
0.0161
pyroglutamyl-Asn-ProNH2
0.069
pyroglutamyl-Gln-Pro-NH2
-
pH 7.5, 37°C, hydrolysis of pyroglutamyl-His-Pro-7-amido-4-methylcoumarin
1.67
Pyroglutamyl-His-Gly
-
37°C
0.582
pyroglutamyl-His-Gly-NH2
-
37°C
0.236
pyroglutamyl-His-Pro
-
37°C
0.0588
pyroglutamyl-His-Pro-Gly
-
37°C
0.0296
pyroglutamyl-His-Pro-Gly-NH2
-
37°C
0.0403
pyroglutamyl-His-Pro-NH2
-
37°C
0.0081
pyroglutamyl-His-Trp-Ser-Tyr-Gly
-
37°C
0.0194
pyroglutamyl-His-Trp-Ser-Tyr-Gly-Leu
-
37°C
0.0603
pyroglutamyl-His-Trp-Ser-Tyr-Gly-Leu-Arg
-
37°C
0.0108
pyroglutamyl-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly
-
37°C
0.5
pyroglutamyl-homoprolyl-Pro-NH2
-
pH 7.5, 37°C, hydrolysis of pyroglutamyl-His-Pro-7-amido-4-methylcoumarin
0.356
pyroglutamyl-L-alpha-phenylglycyl-Pro-NH2
-
pH 7.5, 37°C, hydrolysis of pyroglutamyl-His-Pro-7-amido-4-methylcoumarin
0.0731
pyroglutamyl-Phe-Pro-NH2
-
37°C
0.232
pyroglutamyl-Trp-Pro-NH2
-
pH 7.5, 37°C, hydrolysis of pyroglutamyl-His-Pro-7-amido-4-methylcoumarin
0.0161
pyroglutamyl-Asn-ProNH2
-
-
0.0161
pyroglutamyl-Asn-ProNH2
-
37°C, pH 7.5
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O'Connor, B.; O'Cuinn, G.
Purification of and kinetic studies on a narrow specificity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain
Eur. J. Biochem.
150
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Rattus norvegicus
brenda
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Rattus norvegicus
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Mus musculus (Q9UKU6)
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brenda
Lazcano, I.; Cabral, A.; Uribe, R.M.; Jaimes-Hoy, L.; Perello, M.; Joseph-Bravo, P.; Sanchez-Jaramillo, E.; Charli, J.L.
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Rattus norvegicus (Q10836)
brenda
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Rattus norvegicus (Q10836)
brenda