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2-aminobenzoyl-ALRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
best substrate
-
-
?
2-aminobenzoyl-EE-epsilon-amino-caproic acid-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
-
-
-
?
2-aminobenzoyl-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
-
-
-
?
2-aminobenzoyl-KK-epsilon-amino-caproic acid-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
-
-
-
?
2-aminobenzoyl-KLRSIKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-KLR + SIKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
best substrate
-
-
?
2-aminobenzoyl-KLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
-
-
-
?
2-aminobenzoyl-KLRSXKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-KLR + SXKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
X is varied with diverse amino acids, highest activity with Ile, kinetics, detailed overview
-
-
?
2-aminobenzoyl-KLRVSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
-
-
-
?
2-aminobenzoyl-KLRXSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-KLR + XSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
X is varied with diverse amino acids, highest activity with Val, kinetics, detailed overview
-
-
?
2-aminobenzoyl-KLXSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-KLX + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
X is varied with diverse amino acids, highest activity with Arg, kinetics, detailed overview
-
-
?
2-aminobenzoyl-KPPVVLLPDQ-N-[2,4-dinitrophenyl]ethylenediamine + H2O
2-aminobenzoyl-KPPVV + LLPDQ-N-[2,4-dinitrophenyl]ethylenediamine
-
-
-
-
?
2-aminobenzoyl-KPVSTEQLAQ-N-[2,4-dinitrophenyl]ethylenediamine + H2O
2-aminobenzoyl-KPVS + TEQLAQ-N-[2,4-dinitrophenyl]ethylenediamine
-
-
-
-
?
2-aminobenzoyl-KXRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
X is varied with diverse amino acids, highest activity with Leu, kinetics, detailed overview
-
-
?
2-aminobenzoyl-LFEKQ-N-[2,4-dinitrophenyl]ethylenediamine + H2O
2-aminobenzoyl-LF + EKQ-N-[2,4-dinitrophenyl]ethylenediamine
-
-
-
-
?
2-aminobenzoyl-VLFEKKQ-N-[2,4-dinitrophenyl]ethylenediamine + H2O
2-aminobenzoyl-VLF + EKKQ-N-[2,4-dinitrophenyl]ethylenediamine
-
selective substrate for cathepsin V when compared with cathepsins B, L, and S
-
-
?
2-aminobenzoyl-VLFEKKVYLQ-N-[2,4-dinitrophenyl]ethylenediamine + H2O
2-aminobenzoyl-VLF + EKKVY + LQ-N-[2,4-dinitrophenyl]ethylenediamine
-
-
-
-
?
2-aminobenzoyl-VLFEKQ-N-[2,4-dinitrophenyl]ethylenediamine + H2O
2-aminobenzoyl-VLF + EKQ-N-[2,4-dinitrophenyl]ethylenediamine
-
-
-
-
?
2-aminobenzoyl-XLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
X is varied with diverse amino acids, highest activity with Ala, kinetics, detailed overview
-
-
?
Albumin + H2O
?
-
-
-
-
?
benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Val-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Boc-Gly-Lys-Arg-7-amido-4-methylcoumarin + H2O
Boc-Gly-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Bovine serum albumin + H2O
?
-
-
-
-
?
Cbz-Phe-Arg-7-amido-4-methylcoumarin + H2O
Cbz-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Gelatin + H2O
?
-
-
-
-
?
kininogen fragments + H2O
?
-
kininogenase activity with high and low molecular weight kininogens
Lys-bradykinin is the major product
-
?
MHC class II-associated invariant chain + H2O
?
-
-
-
-
?
N-benzyloxycarbonyl-L-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-Arg + 7-amino-4-methylcoumarin
-
very low activity
-
?
N-benzyloxycarbonyl-L-Arg-L-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin
-
very low activity
-
?
N-benzyloxycarbonyl-L-Phe-L-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
neuropeptide Y + H2O
?
-
-
-
?
proenkephalin + H2O
(Met)enkephalin + ?
-
-
-
?
Type I collagen + H2O
?
-
cleavage of telopeptide region
-
-
?
Z-Arg-Arg-4-methoxy-2-nitroanilide + H2O
Z-Arg-Arg + 4-methoxy-2-nitroaniline
-
-
-
-
?
Z-Arg-Arg-7-amido-4-methylcoumarin + H2O
Z-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Z-Leu-Arg-7-amido-4-methylcoumarin + H2O
Z-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Z-Phe-Arg-4-methylcoumarin-7-amide + H2O
Z-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O
Z-Phe-Arg + 7-amino-4-methylcoumarin
additional information
?
-
benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Elastin + H2O
?
-
-
-
-
?
Elastin + H2O
?
-
elastin degradation activity leading to loss of elasticity in atherosclerosis
-
-
?
Elastin + H2O
?
-
the enzyme exhibits high elastolytic cysteine protease activity
-
-
?
N-benzyloxycarbonyl-L-Phe-L-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
N-benzyloxycarbonyl-L-Phe-L-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
?
N-benzyloxycarbonyl-L-Phe-L-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
Cbz-Phe-Arg-AMC, 25 microM used for protease inhibition assay, inhibitory conditions of cathepsin V propeptide analyzed
-
-
?
N-benzyloxycarbonyl-L-Phe-L-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
mechanisms of interaction between serpins, human cathepsin V and DNA analyzed, kinetic constants for substrate cleavage in the presence and absence of cofactors determined, final concentrations of cathepsin V and ds65mer DNA at 0.1 and 10 nM, final substrate concentrations ranging from 5 to 200 microM in cathepsin V buffer
-
-
?
plasminogen + H2O
?
-
-
-
?
plasminogen + H2O
?
capability of recombinant human cathepsin V to hydrolyze plasminogen analyzed, physiological role for cathepsin V related to the control of neovascularization in cornea suggested
-
-
?
plasminogen + H2O
?
4.5 microM human plasminogen and 30 nM of recombinant human cathepsins V used for plasminogen digestion assay, three major products of 60, 50 and 40 kDa obtained, SDS-PAGE
-
-
?
plasminogen + H2O
?
-
cathepsin V hydrolyzes plasminogen at Phe94-Glu95, Ser358-Thr359, and Val468-Leu469 generating angiostatin-related fragments
-
-
?
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O
Z-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O
Z-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O
Z-Phe-Arg + 7-amino-4-methylcoumarin
role of cathepsis V and the endogenous inhibitor cystatin C in adverse extracellular matrix remodeling of stenotic aortic valves analyzed
-
-
?
additional information
?
-
-
the corneal enzyme stays within cells and is not secreted, suggesting that components of the corneal epithelium are likely substrates
-
-
?
additional information
?
-
-
the predominant expression in thymus suggests a role in the immune system, the expression in testes suggests a role in fertilization processes, the expression in cancer cells together with its absence in normal cells suggests a role in tumor processes
-
-
?
additional information
?
-
-
the enzyme and inhibitor cystatin M/E are involved in regulation of epidermal differentiation
-
-
?
additional information
?
-
-
the enzyme can stimulate H2O2 production, enzyme expression is increased in keratoconus corneas compared to healthy ones, oxidative stress might be involved in the disorder
-
-
?
additional information
?
-
-
substrate and cleavage site specificity of activated recombinant enzyme, comparison to cathepsin L, overview
-
-
?
additional information
?
-
-
the enzyme prefers hydrophobic residues in its S2-binding pocket, the substrate specificity is similar to cathepsin L, no cleavage of the triple-helical region of native collagen
-
-
?
additional information
?
-
-
the human transglutaminase zymogen is no substrate for the enzyme
-
-
?
additional information
?
-
direct interaction of cathepsin V with TLR4 and its adaptor protein MyD88
-
-
?
additional information
?
-
-
direct interaction of cathepsin V with TLR4 and its adaptor protein MyD88
-
-
?
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(1R)-1-{2-[butyl(dichloro)-l4-tellanyl]phenyl}ethyl methyl ether
-
less than 10% residual activity at 0.001 mM
(1R)-1-{2-[dibromo(butyl)-l4-tellanyl]phenyl}ethyl methyl ether
-
less than 10% residual activity at 0.001 mM
(1S)-1-{2-[butyl(dichloro)-l4-tellanyl]phenyl}ethyl methyl ether
-
less than 10% residual activity at 0.001 mM
(1S)-1-{2-[dibromo(butyl)-l4-tellanyl]phenyl}ethyl methyl ether
-
less than 10% residual activity at 0.001 mM
1,3,5-trihydroxy-2,8-bis(3-methylbut-2-enyl)-10-methyl-9-acridone
-
-
1,3,5-trihydroxy-4-methoxy-10-methyl-2,8-bis(3-methylbut-2-enyl)acridin-9(10H)-one
-
-
2,3-dihydro-4,9-dihydroxy-2-(2-hydroxy-propan-2-yl)-11-methoxy-10-methylfuro[3,2-b]acridin-5(10H)-one
-
-
2-[butyl(dichloro)-l4-tellanyl]benzyl methyl ether
-
about 10% residual activity at 0.001 mM
2-[dibromo(butyl)-l4-tellanyl]benzyl methyl ether
-
less than 10% residual activity at 0.001 mM
3,4-dihydro-3,5,8-trihydroxy-6-methoxy-2,2,7-trimethyl-2H-pyrano[2,3-a]acridin-12(7H)-one
-
-
4-fluoro-N-prop-2-yn-1-yl-N2-[(1S)-2,2,2-trifluoro-1-[4'-(methanesulfonyl)[1,1'-biphenyl]-4-yl]ethyl]-L-leucinamide
-
4-methylpiperazine-1-carboxylic acid [1-[(3-benzenesulfonyl-1-phenethylallyl)carbamoyl]-2-phenylethyl]amide
-
i.e. APC-3316
4-morpholincarbonyl-Leu-homophenylalaninevinyl sulfone-phenyl
-
5-hydroxynoracronycine
-
-
cathepsin V propeptide
CatV PP, tight-binding inhibitor
-
chondroitin 4-sulfate
-
specific inhibition of elastolytic activity, formation of specific complexes with the enzyme, no inhibition of the activity with Z-Phe-Arg-4-methyl-7-coumaryl amide
cystatin C
endogenous inhibitor of cathepsin V analyzed, expression of cystatin C increased in stenotic valves, cystatin C protein particularly found in areas with infiltrates of inflammatory cells
-
fragment p41 of major histocompatibility complex class II-associated invariant chain
-
inhibitory to human cathepsin V, cathepsin L, cathepsin K, cathepsin F with Ki values in the low nanomolar range. Ki values are sufficiently low to ensure complex formation at physiological concentrations. Regulation of the proteolytic activity of most of the cysteine cathepsins by the p41 fragment is an important and widespread control mechanism of antigen presentation
-
morpholineurea-leucyl-homophenylalanine-vinylsulfone phenyl
-
-
morpholineurea-naphthyl-homophenylalanine-vinylsulfone naphthyl
-
-
-
N-(3-bromoprop-2-yn-1-yl)-4-fluoro-N2-[(1S)-2,2,2-trifluoro-1-[4'-(methanesulfonyl)[1,1'-biphenyl]-4-yl]ethyl]-L-leucinamide
-
N-(cyanomethyl)-4-fluoro-N2-[(1S)-2,2,2-trifluoro-1-[4'-(methanesulfonyl)[1,1'-biphenyl]-4-yl]ethyl]-L-leucinamide
-
N-but-3-yn-2-yl-4-fluoro-N2-[(1S)-2,2,2-trifluoro-1-[4'-(methanesulfonyl)[1,1'-biphenyl]-4-yl]ethyl]-L-leucinamide
-
N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide
peptidl vinyl sulfones
-
-
-
saquinavir
SQV, the HIV protease inhibitor Inhibits the interaction between cathepsin V and the TLR4-MyD88 receptor complex, also blocks disulfide HMGB1-induced TLR4 activation
serpin
cofactors fine tuning serpin activity in the extracellular milieu analyzed, DNA accelerate the rate at which the model serpin MENT inhibit cathepsin V up to 50-fold, primarily effected via the protease and secondarily by the recruitment of the DNA as a template onto which cathepsin V and MENT are bound, altered substrate turnover and conformational change within the protease observed, enzyme concentration constant at 0.1 nM, serpin concentration varying between 0.5 and 60 nM with a maximum of 5 nM serpin in the presence of DNA
-
STO33438
334, a mammalian protease inhibitor, inhibits cathepsin V, also blocks disulfide HMGB1-induced TLR4 activation
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
VBY-825
-
reversible cathepsin inhibitor with high potency against cathepsins V
calpeptin
-
cystatin
-
-
cystatin
cystatin inhibition relies on occlusion of the active site rather than the substrate-like behavior of serpins, unaltered by addition of DNA
-
cystatin M/E
-
cystatin M/E wild-type and mutant N64A show high affinity for cathepsin V, but not cystatin M/E mutant W135A
-
cystatin M/E
-
regulatory role, two distinct binding sites for cysteine proteases of the C1 peptidase family, the endogenous inhibitor is co-localized with the enzyme in lamellar granules and corneodesmosomes
-
cystatin M/E
-
the antiprotease activity of cystatin M/E inhibits the activity of cathepsin V
-
cystatin M/E
-
high-affinity inhibitor of cathepsin V, directly controls the activity of cathepsin V
-
E-64
-
-
leupeptin
-
N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide
SID, suppresses the activity of cathepsin V and reverses the upregulation of inflammatory cytokines (IL-6, IL-8 and TNF-alpha), adhesion and chemotaxis of leukocytes and vascular inflammation induced by L-homocysteine (L-Hcy) in vivo and in vitro. SID also inhibits the monocyte-endothelial adhesion and neutrophil chemotaxis induced by L-Hcy. SID reverses this increased phosphorylation of ERK1/2 and STAT1, which is similar to the results obtained in vitro
N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide
SID, inhibits the enzyme and also blocks HMGB1-induced TNF-alpha production
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
i.e. E-64
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
-
-
additional information
inhibitor screening, overview
-
additional information
-
inhibitor screening, overview
-
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Alopecia
Evaluation of the CTSL2 Gene as a Candidate Gene For Alopecia X in Pomeranians and Keeshonden.
Arthritis
Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis.
Arthritis, Juvenile
Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis.
Arthritis, Rheumatoid
Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis.
Atherosclerosis
Solution phase synthesis of a combinatorial library of chalcones and flavones as potent cathepsin V inhibitors.
Autoimmune Diseases
Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis.
Breast Neoplasms
An exploratory study of host polymorphisms in genes that clinically characterize breast cancer tumors and pretreatment cognitive performance in breast cancer survivors.
Breast Neoplasms
Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer.
Carcinogenesis
Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer.
Carcinoma
Significance of nuclear cathepsin V in normal thyroid epithelial and carcinoma cells.
Carcinoma, Ductal
Prognostic significance of cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ.
Carcinoma, Hepatocellular
Elevated CTSL2 expression is associated with an adverse prognosis in hepatocellular carcinoma.
Carcinoma, Intraductal, Noninfiltrating
Prognostic significance of cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ.
Colorectal Neoplasms
Cathepsin V Mediates the Tazarotene-induced Gene 1-induced Reduction in Invasion in Colorectal Cancer Cells.
Dermatitis, Atopic
The cystatin M / E-controlled pathway of skin barrier formation: expression of its key components in psoriasis and atopic dermatitis.
Endometrial Neoplasms
Expression of cysteine protease cathepsin L is increased in endometrial cancer and correlates with expression of growth regulatory genes.
Goiter
Significance of nuclear cathepsin V in normal thyroid epithelial and carcinoma cells.
Hyperhomocysteinemia
HMGB1 mediates homocysteine-induced endothelial cells pyroptosis via cathepsin V-dependent pathway.
Keratoconus
Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder.
Lung Neoplasms
Manipulating substrate and pH in zymography protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissues.
Mucopolysaccharidoses
The abnormal accumulation of heparan sulfate in patients with mucopolysaccharidosis prevents the elastolytic activity of cathepsin V.
Myasthenia Gravis
Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis.
Neoplasm Metastasis
Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer.
Neoplasm Metastasis
Determination of cathepsin V activity and intracellular trafficking by N-glycosylation.
Neoplasms
An exploratory study of host polymorphisms in genes that clinically characterize breast cancer tumors and pretreatment cognitive performance in breast cancer survivors.
Neoplasms
Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer.
Neoplasms
CTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis.
Neoplasms
Determination of cathepsin V activity and intracellular trafficking by N-glycosylation.
Neoplasms
Elevated CTSL2 expression is associated with an adverse prognosis in hepatocellular carcinoma.
Neoplasms
Expression of cysteine protease cathepsin L is increased in endometrial cancer and correlates with expression of growth regulatory genes.
Neoplasms
Manipulating substrate and pH in zymography protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissues.
Neuroblastoma
Human cathepsin V protease participates in the production of enkephalin and NPY neurotransmitters.
Placenta Accreta
Possible Association between Cathepsin V and the Development of Placenta Accreta Spectrum Disorders.
Psoriasis
The cystatin M / E-controlled pathway of skin barrier formation: expression of its key components in psoriasis and atopic dermatitis.
Sarcoidosis, Pulmonary
Endostatin and cathepsin-V in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis.
Scleroderma, Systemic
Decreased cathepsin V expression due to Fli1 deficiency contributes to the development of dermal fibrosis and proliferative vasculopathy in systemic sclerosis.
Thyroid Cancer, Papillary
Significance of nuclear cathepsin V in normal thyroid epithelial and carcinoma cells.
Vascular Diseases
l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia.
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0.0039
1,3,5-trihydroxy-2,8-bis(3-methylbut-2-enyl)-10-methyl-9-acridone
Homo sapiens
-
in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C
0.0025
1,3,5-trihydroxy-4-methoxy-10-methyl-2,8-bis(3-methylbut-2-enyl)acridin-9(10H)-one
Homo sapiens
-
in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C
0.0052
2,3-dihydro-4,9-dihydroxy-2-(2-hydroxy-propan-2-yl)-11-methoxy-10-methylfuro[3,2-b]acridin-5(10H)-one
Homo sapiens
-
in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C
0.0028
3,4-dihydro-3,5,8-trihydroxy-6-methoxy-2,2,7-trimethyl-2H-pyrano[2,3-a]acridin-12(7H)-one
Homo sapiens
-
in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C
0.024
4-fluoro-N-prop-2-yn-1-yl-N2-[(1S)-2,2,2-trifluoro-1-[4'-(methanesulfonyl)[1,1'-biphenyl]-4-yl]ethyl]-L-leucinamide
Homo sapiens
50 mM MES pH 5.5, 25 mM EDTA and 2.5 mM DTT. 0.05% Tween 20 (v/v), 37°C
0.048
5-hydroxynoracronycine
Homo sapiens
-
in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C
0.0012
citibrasine
Homo sapiens
-
in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C
0.0022
citrusinine-I
Homo sapiens
-
in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C
0.01
citrusinine-II
Homo sapiens
-
in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C
0.025
glycocitrine-I
Homo sapiens
-
in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C
0.0022
glycocitrine-IV
Homo sapiens
-
in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C
0.000016
N-(3-bromoprop-2-yn-1-yl)-4-fluoro-N2-[(1S)-2,2,2-trifluoro-1-[4'-(methanesulfonyl)[1,1'-biphenyl]-4-yl]ethyl]-L-leucinamide
Homo sapiens
50 mM MES pH 5.5, 25 mM EDTA and 2.5 mM DTT. 0.05% Tween 20 (v/v), 37°C
0.00091
N-(cyanomethyl)-4-fluoro-N2-[(1S)-2,2,2-trifluoro-1-[4'-(methanesulfonyl)[1,1'-biphenyl]-4-yl]ethyl]-L-leucinamide
Homo sapiens
50 mM MES pH 5.5, 25 mM EDTA and 2.5 mM DTT. 0.05% Tween 20 (v/v), 37°C
0.046
N-but-3-yn-2-yl-4-fluoro-N2-[(1S)-2,2,2-trifluoro-1-[4'-(methanesulfonyl)[1,1'-biphenyl]-4-yl]ethyl]-L-leucinamide
Homo sapiens
50 mM MES pH 5.5, 25 mM EDTA and 2.5 mM DTT. 0.05% Tween 20 (v/v), 37°C
0.0006
odanacatib
Homo sapiens
50 mM MES pH 5.5, 25 mM EDTA and 2.5 mM DTT. 0.05% Tween 20 (v/v), 37°C
0.044
pyranofoline
Homo sapiens
-
in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C
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Brmme, D.; Li, Z.; Barnes, M.; Mehler, E.
Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization
Biochemistry
38
2377-2385
1999
Homo sapiens (O60911), Homo sapiens
brenda
Adachi, W.; Kawamoto, S.; Ohno, I.; Nishida, K.; Kinoshita, S.; Matsubara, K.; Okubo, K.
Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium
Invest. Ophthalmol. Vis. Sci.
39
1789-1796
1998
Homo sapiens
brenda
Santamaria, I.; Velasco, G.; Cazorla, M.; Fueyo, A.; Campo, E.; Lopez-Otin, C.
Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas
Cancer Res.
58
1624-1630
1998
Homo sapiens
brenda
Somoza, J.R.; Zhan, H.; Bowman, K.K.; Yu, L.; Mortara, K.D.; Palmer, J.T.; Clark, J.M.; McGrath, M.E.
Crystal structure of human cathepsin V
Biochemistry
39
12543-12551
2000
Homo sapiens
brenda
Puzer, L.; Cotrin, S.S.; Alves, M.F.; Egborge, T.; Araujo, M.S.; Juliano, M.A.; Juliano, L.; Broemme, D.; Carmona, A.K.
Comparative substrate specificity analysis of recombinant human cathepsin V and cathepsin L
Arch. Biochem. Biophys.
430
274-283
2004
Homo sapiens
brenda
Hagemann, S.; Guenther, T.; Dennemaerker, J.; Lohmueller, T.; Broemme, D.; Schuele, R.; Peters, C.; Reinheckel, T.
The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles
Eur. J. Cell Biol.
83
775-780
2004
Homo sapiens
brenda
Broemme, D.
Cathepsin V
Handbook of Proteolytic Enzymes (Barrett, A.J., Rawlings, N.D., Woessner, J.F., eds)
2nd Ed.
1107-1109
2004
Homo sapiens
-
brenda
Kenney, M.C.; Chwa, M.; Atilano, S.R.; Tran, A.; Carballo, M.; Saghizadeh, M.; Vasiliou, V.; Adachi, W.; Brown, D.J.
Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder
Invest. Ophthalmol. Vis. Sci.
46
823-832
2005
Homo sapiens
brenda
Yasuda, Y.; Li, Z.; Greenbaum, D.; Bogyo, M.; Weber, E.; Broemme, D.
Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages
J. Biol. Chem.
279
36761-36770
2004
Homo sapiens
brenda
Cheng, T.; Hitomi, K.; van Vlijmen-Willems, I.M.; de Jongh, G.J.; Yamamoto, K.; Nishi, K.; Watts, C.; Reinheckel, T.; Schalkwijk, J.; Zeeuwen, P.L.
Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification
J. Biol. Chem.
281
15893-15899
2006
Homo sapiens
brenda
Zeeuwen, P.L.; Ishida-Yamamoto, A.; van Vlijmen-Willems, I.M.; Cheng, T.; Bergers, M.; Iizuka, H.; Schalkwijk, J.
Colocalization of cystatin M/E and cathepsin V in lamellar granules and corneodesmosomes suggests a functional role in epidermal differentiation
J. Invest. Dermatol.
127
120-128
2006
Homo sapiens
brenda
Helske, S.; Syvaeranta, S.; Lindstedt, K.A.; Lappalainen, J.; Oeoerni, K.; Maeyraenpaeae, M.I.; Lommi, J.; Turto, H.; Werkkala, K.; Kupari, M.; Kovanen, P.T.
Increased Expression of Elastolytic Cathepsins S, K, and V and Their Inhibitor Cystatin C in Stenotic Aortic Valves
Arterioscler. Thromb. Vasc. Biol.
26
1791-1798
2006
Homo sapiens (O60911)
brenda
Burden, R.E.; Snoddy, P.; Jefferies, C.A.; Walker, B.; Scott, C.J.
Inhibition of cathepsin L-like proteases by cathepsin V propeptide
Biol. Chem.
388
541-545
2007
Homo sapiens (O60911)
brenda
Puzer, L.; Barros, N.M.; Paschoalin, T.; Hirata, I.Y.; Tanaka, A.S.; Oliveira, M.C.; Broemme, D.; Carmona, A.K.
Cathepsin V, but not cathepsins L, B and K, may release angiostatin-like fragments from plasminogen
Biol. Chem.
389
195-200
2008
Homo sapiens (O60911), Homo sapiens
brenda
Ong, P.C.; McGowan, S.; Pearce, M.C.; Irving, J.A.; Kan, W.T.; Grigoryev, S.A.; Turk, B.; Silverman, G.A.; Brix, K.; Bottomley, S.P.; Whisstock, J.C.; Pike, R.N.
DNA accelerates the inhibition of human cathepsin V by serpins
J. Biol. Chem.
282
36980-36986
2007
Homo sapiens (O60911), Homo sapiens
brenda
Mihelic, M.; Dobersek, A.; Guncar, G.; Turk, D.
Inhibitory fragment from the p41 form of invariant chain can regulate activity of cysteine cathepsins in antigen presentation
J. Biol. Chem.
283
14453-14460
2008
Homo sapiens
brenda
Elie, B.T.; Gocheva, V.; Shree, T.; Dalrymple, S.A.; Holsinger, L.J.; Joyce, J.A.
Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model
Biochimie
92
1618-1624
2010
Homo sapiens
brenda
Sevenich, L.; Hagemann, S.; Stoeckle, C.; Tolosa, E.; Peters, C.; Reinheckel, T.
Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice
Biochimie
92
1674-1680
2010
Homo sapiens
brenda
Coppini, L.P.; Barros, N.M.; Oliveira, M.; Hirata, I.Y.; Alves, M.F.; Paschoalin, T.; Assis, D.M.; Juliano, M.A.; Puzer, L.; Broemme, D.; Carmona, A.K.
Plasminogen hydrolysis by cathepsin S and identification of derived peptides as selective substrate for cathepsin V and cathepsin L inhibitor
Biol. Chem.
391
561-570
2010
Homo sapiens
brenda
Cheng, T.; Tjabringa, G.S.; van Vlijmen-Willems, I.M.; Hitomi, K.; van Erp, P.E.; Schalkwijk, J.; Zeeuwen, P.L.
The cystatin M/E-controlled pathway of skin barrier formation: expression of its key components in psoriasis and atopic dermatitis
Br. J. Dermatol.
161
253-264
2009
Homo sapiens
brenda
Renko, M.; Sabotic, J.; Mihelic, M.; Brzin, J.; Kos, J.; Turk, D.
Versatile loops in mycocypins inhibit three protease families
J. Biol. Chem.
285
308-316
2010
Homo sapiens (O60911)
brenda
Zeeuwen, P.L.; Cheng, T.; Schalkwijk, J.
The biology of cystatin M/E and its cognate target proteases
J. Invest. Dermatol.
129
1327-1338
2009
Homo sapiens
brenda
Wilder, C.L.; Park, K.Y.; Keegan, P.M.; Platt, M.O.
Manipulating substrate and pH in zymography protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissues
Arch. Biochem. Biophys.
516
52-57
2011
Homo sapiens
brenda
Severino, R.P.; Guido, R.V.; Marques, E.F.; Broemme, D.; da Silva, M.F.; Fernandes, J.B.; Andricopulo, A.D.; Vieira, P.C.
Acridone alkaloids as potent inhibitors of cathepsin V
Bioorg. Med. Chem.
19
1477-1481
2011
Homo sapiens
brenda
Piovan, L.; Alves, M.F.; Juliano, L.; Broemme, D.; Cunha, R.L.; Andrade, L.H.
Structure-activity relationships of hypervalent organochalcogenanes as inhibitors of cysteine cathepsins V and S
Bioorg. Med. Chem.
19
2009-2014
2011
Homo sapiens
brenda
McCarthy, E.; Cunningham, E.; Copley, L.; Jackson, D.; Johnston, D.; Dalton, J.; Mulcahy, G.
Cathepsin L proteases of the parasitic copepod, Lepeophtheirus salmonis
Aquaculture
356-357
264-271
2012
Lepeophtheirus salmonis (A7TZ36)
-
brenda
Skrzypczak, M.; Springwald, A.; Lattrich, C.; Haering, J.; Schueler, S.; Ortmann, O.; Treeck, O.
Expression of cysteine protease cathepsin L is increased in endometrial cancer and correlates with expression of growth regulatory genes
Cancer Invest.
30
398-403
2012
Homo sapiens (O60911), Homo sapiens
brenda
Funkelstein, L.; Lu, W.D.; Koch, B.; Mosier, C.; Toneff, T.; Taupenot, L.; O'Connor, D.T.; Reinheckel, T.; Peters, C.; Hook, V.
Human cathepsin V protease participates in production of enkephalin and NPY neuropeptide neurotransmitters
J. Biol. Chem.
287
15232-15241
2012
Homo sapiens (O60911), Homo sapiens
brenda
Keegan, P.M.; Wilder, C.L.; Platt, M.O.
Tumor necrosis factor alpha stimulates cathepsin K and V activity via juxtacrine monocyte-endothelial cell signaling and JNK activation
Mol. Cell. Biochem.
367
65-72
2012
Homo sapiens (O60911), Homo sapiens
brenda
Wong, C.H.; Wu, Z.; Yu, Q.
CTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis
Oncogene
33
1249-1257
2014
Homo sapiens (O60911), Homo sapiens
brenda
Novinec, M.; Pavsic, M.; Lenarcic, B.
A simple and efficient protocol for the production of recombinant cathepsin V and other cysteine cathepsins in soluble form in Escherichia coli
Protein Expr. Purif.
82
1-5
2012
Homo sapiens (O60911)
brenda
Naumnik, W.; Ossolinska, M.; Plonska, I.; Chyczewska, E.; Niklinski, J.
Endostatin and cathepsin-V in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis
Adv. Exp. Med. Biol.
833
55-61
2015
Homo sapiens (O60911), Homo sapiens
brenda
Homma, T.; Kageyama, S.; Nishikawa, A.; Nagata, K.
Melanosome degradation in epidermal keratinocytes related to lysosomal protease cathepsin V
Biochem. Biophys. Res. Commun.
500
339-343
2018
Homo sapiens (O60911)
brenda
Leng, Y.P.; Ma, Y.S.; Li, X.G.; Chen, R.F.; Zeng, P.Y.; Li, X.H.; Qiu, C.F.; Li, Y.P.; Zhang, Z.; Chen, A.F.
L-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia
Br. J. Pharmacol.
175
1157-1172
2018
Homo sapiens (O60911), Homo sapiens
brenda
Huang, K.; Gao, L.; Yang, M.; Wang, J.; Wang, Z.; Wang, L.; Wang, G.; Li, H.
Exogenous cathepsin V protein protects human cardiomyocytes HCM from angiotensin II-induced hypertrophy
Int. J. Biochem. Cell Biol.
89
6-15
2017
Homo sapiens (O60911), Homo sapiens
brenda
Mons, E.; Jansen, I.D.C.; Loboda, J.; van Doodewaerd, B.R.; Hermans, J.; Verdoes, M.; van Boeckel, C.A.A.; van Veelen, P.A.; Turk, B.; Turk, D.; Ovaa, H.
The Alkyne moiety as a latent electrophile in irreversible covalent small molecule inhibitors of cathepsin K
J. Am. Chem. Soc.
141
3507-3514
2019
Homo sapiens (P07711)
brenda
Pribis, J.P.; Al-Abed, Y.; Yang, H.; Gero, D.; Xu, H.; Montenegro, M.F.; Bauer, E.M.; Kim, S.; Chavan, S.S.; Cai, C.; Li, T.; Szoleczky, P.; Szabo, C.; Tracey, K.J.; Billiar, T.R.
The HIV protease inhibitor saquinavir inhibits HMGB1-driven inflammation by targeting the interaction of cathepsin V with TLR4/MyD88
Mol. Med.
21
749-757
2015
Homo sapiens (O60911), Homo sapiens
brenda