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Disease on EC 3.6.1.23 - dUTP diphosphatase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Expression of deoxyuridine triphosphatase (dUTPase) in colorectal tumours.
Adenoma
Expression of deoxyuridine triphosphatase (dUTPase) in colorectal tumours.
African Swine Fever
African swine fever virus dUTPase is a highly specific enzyme required for efficient replication in swine macrophages.
Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target.
Orf virus encodes a functional dUTPase gene.
Structural Insight into African Swine Fever Virus dUTPase Reveals a Novel Folding Pattern in the dUTPase Family.
Alzheimer Disease
[Molecular cloning and identification and biological activity of GIF-interacting protein(s)]
Anemia
"Hidden" dUTPase sequence in human immunodeficiency virus type 1 gp120.
Characterization and mutational studies of equine infectious anemia virus dUTPase.
Characterization of equine infectious anemia virus dUTPase: growth properties of a dUTPase-deficient mutant.
Crystal structure of dUTPase from equine infectious anaemia virus; active site metal binding in a substrate analogue complex.
dUTPase from the retrovirus equine infectious anemia virus: high-level expression in Escherichia coli and purification.
dUTPase from the retrovirus equine infectious anemia virus: specificity, turnover and inhibition.
Incorporation of uracil into viral DNA correlates with reduced replication of EIAV in macrophages.
Replication in vitro and in vivo of an equine infectious anemia virus mutant deficient in dUTPase activity.
Specific derivatization of the active site tyrosine in dUTPase perturbs ligand binding to the active site.
The dUTPase-related gene of bovine immunodeficiency virus is critical for viral replication, despite the lack of dUTPase activity of the encoded protein.
The role of retroviral dUTPases in replication and virulence.
Transient kinetics of ligand binding and role of the C-terminus in the dUTPase from equine infectious anemia virus.
Anemia, Megaloblastic
Elevated deoxyuridine triphosphate nucleotidohydrolase (dUTPase) activity in the cobalamin-deficient megaloblastic bone marrow cells.
Astrocytoma
Immunohistochemical detection of dUTPase in intracranial tumors.
Bone Marrow Failure Disorders
dUTPase (DUT) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure.
Breast Neoplasms
Novel opportunities for thymidylate metabolism as a therapeutic target.
The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells.
Burkitt Lymphoma
Expression of viral and human dUTPase in Epstein-Barr virus-associated diseases.
Carcinogenesis
Epstein-Barr virus encoded dUTPase containing exosomes modulate innate and adaptive immune responses in human dendritic cells and peripheral blood mononuclear cells.
Carcinoma
CKS2 modulates cell-cycle progression of tongue squamous cell carcinoma cells partly via modulating the cellular distribution of DUTPase.
Expression of deoxyuridine triphosphatase (dUTPase) in colorectal tumours.
Immunohistochemical detection of dUTPase in intracranial tumors.
Phosphorylation of herpes simplex virus 1 dUTPase upregulated viral dUTPase activity to compensate for low cellular dUTPase activity for efficient viral replication.
Synergy between the NAMPT inhibitor GMX1777(8) and pemetrexed in non-small cell lung cancer cells is mediated by PARP activation and enhanced NAD consumption.
Carcinoma, Hepatocellular
Characterization and functional studies of fowl adenovirus 9 dUTPase.
Deoxyuridine triphosphatase in human hepatoma.
dUTP pyrophosphatase and uracil-DNA glycosylase in rat liver and hepatomas.
dUTP pyrophosphatase expression correlates with a poor prognosis in hepatocellular carcinoma.
The reduction of uridine 5'-diphosphate and uridine 5'-triphosphate in some transplantable rat hepatomas.
Carcinoma, Non-Small-Cell Lung
Inhibition of dUTPase Induces Synthetic Lethality with Thymidylate Synthase-Targeted Therapies in Non-Small Cell Lung Cancer.
Synergy between the NAMPT inhibitor GMX1777(8) and pemetrexed in non-small cell lung cancer cells is mediated by PARP activation and enhanced NAD consumption.
Carcinoma, Squamous Cell
CKS2 modulates cell-cycle progression of tongue squamous cell carcinoma cells partly via modulating the cellular distribution of DUTPase.
Chagas Disease
The crystal structure of Trypanosoma cruzi dUTPase reveals a novel dUTP/dUDP binding fold.
Chickenpox
Nationwide distribution of varicella-zoster virus clades in China.
The simian varicella virus uracil DNA glycosylase and dUTPase genes are expressed in vivo, but are non-essential for replication in cell culture.
Colonic Neoplasms
dUTP nucleotidohydrolase isoform expression in normal and neoplastic tissues: association with survival and response to 5-fluorouracil in colorectal cancer.
Lack of dependence of 5-fluorodeoxyuridine-mediated radiosensitization on cytotoxicity.
Macrophages from cancer patients: analysis of TRAIL, TRAIL receptors, and colon tumor cell apoptosis.
The role of dUTPase and uracil-DNA repair in cancer chemotherapy.
Colorectal Neoplasms
dUTP nucleotidohydrolase isoform expression in normal and neoplastic tissues: association with survival and response to 5-fluorouracil in colorectal cancer.
Expression of deoxyuridine triphosphatase (dUTPase) in colorectal tumours.
Higher expression of deoxyuridine triphosphatase (dUTPase) may predict the metastasis potential of colorectal cancer.
Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase.
The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis.
Communicable Diseases
Keeping Uracil Out of DNA: Physiological Role, Structure and Catalytic Mechanism of dUTPases.
Cysticercosis
Taenia solium dUTPase: A potential target for anti-human cysticercosis.
dutp diphosphatase deficiency
Description of a novel eukaryotic deoxyuridine 5'-triphosphate nucleotidohydrolase in Leishmania major.
Pyrimidine requirements in deoxyuridine triphosphate nucleotidohydrolase deficient Trypanosoma brucei mutants.
Ectromelia
The genome of swinepox virus.
Encephalitis
"Hidden" dUTPase sequence in human immunodeficiency virus type 1 gp120.
Enteritis
Identification and characterization of duck enteritis virus dUTPase gene.
Ependymoma
Immunohistochemical detection of dUTPase in intracranial tumors.
Epstein-Barr Virus Infections
Expression of viral and human dUTPase in Epstein-Barr virus-associated diseases.
The EBV-encoded dUTPase activates NF-kappa B through the TLR2 and MyD88-dependent signaling pathway.
Equine Infectious Anemia
"Hidden" dUTPase sequence in human immunodeficiency virus type 1 gp120.
Characterization and mutational studies of equine infectious anemia virus dUTPase.
Characterization of equine infectious anemia virus dUTPase: growth properties of a dUTPase-deficient mutant.
Crystal structure of dUTPase from equine infectious anaemia virus; active site metal binding in a substrate analogue complex.
dUTPase from the retrovirus equine infectious anemia virus: high-level expression in Escherichia coli and purification.
dUTPase from the retrovirus equine infectious anemia virus: specificity, turnover and inhibition.
Incorporation of uracil into viral DNA correlates with reduced replication of EIAV in macrophages.
Replication in vitro and in vivo of an equine infectious anemia virus mutant deficient in dUTPase activity.
Specific derivatization of the active site tyrosine in dUTPase perturbs ligand binding to the active site.
The dUTPase-related gene of bovine immunodeficiency virus is critical for viral replication, despite the lack of dUTPase activity of the encoded protein.
The role of retroviral dUTPases in replication and virulence.
Transient kinetics of ligand binding and role of the C-terminus in the dUTPase from equine infectious anemia virus.
Fatigue Syndrome, Chronic
Antibody to Epstein-Barr virus deoxyuridine triphosphate nucleotidohydrolase and deoxyribonucleotide polymerase in a chronic fatigue syndrome subset.
Fragile X Syndrome
Antifolate-induced misincorporation of deoxyuridine monophosphate into DNA by cells from patients with the fragile X syndrome.
Herpes Simplex
Analysis of cyclin-dependent kinase activity after herpes simplex virus type 2 infection.
Characterization of a herpes simplex virus type 2 deoxyuridine triphosphate nucleotidohydrolase and mapping of a gene conferring type specificity for the enzyme.
Demonstration of a herpes simplex virus type 2-induced deoxyuridine triphosphate nucleotidohydrolase in infected KB cells and in biochemically transformed HeLa cells.
Deoxyuridine triphosphate nucleotidohydrolase induced by herpes simplex virus type 1. Purification and characterization of induced enzyme.
dUTPase from herpes simplex virus type 1; purification from infected green monkey kidney (Vero) cells and from an overproducing Escherichia coli strain.
Effects of mercury (II) compounds on the activity of dUTPases from various sources.
Herpes simplex virus 1 protein kinase Us3 phosphorylates viral dUTPase and regulates its catalytic activity in infected cells.
Herpes simplex virus type 1 dUTPase mutants are attenuated for neurovirulence, neuroinvasiveness, and reactivation from latency.
Herpes simplex virus-induced dUTPase: target site for antiviral chemotherapy.
Identification and deletion mutagenesis of the bovine herpesvirus 1 dUTPase gene and a gene homologous to herpes simplex virus UL49.5.
Identification of the herpes simplex virus type 1 gene encoding the dUTPase.
Induction of uracil-DNA glycosylase and dUTP nucleotidohydrolase activity in herpes simplex virus-infected human cells.
Inhibition of phosphorylation of cellular dUTP nucleotidohydrolase as a consequence of herpes simplex virus infection.
Isolation and characterisation of herpes simplex virus type 1 mutants which fail to induce dUTPase activity.
Kinetic properties and stereospecificity of the monomeric dUTPase from herpes simplex virus type 1.
Mutations in accessory DNA replicating functions alter the relative mutation frequency of herpes simplex virus type 1 strains in cultured murine cells.
Nucleotide sequence of a 55 kbp region from the right end of the genome of a pathogenic African swine fever virus isolate (Malawi LIL20/1).
Phosphorylation of a herpes simplex virus 1 dUTPase by a viral protein kinase, Us3, dictates viral pathogenicity in the central nervous system but not at the periphery.
Phosphorylation of herpes simplex virus 1 dUTPase regulates viral virulence and genome integrity by compensating for low cellular dUTPase activity in the central nervous system.
Phosphorylation of herpes simplex virus 1 dUTPase upregulated viral dUTPase activity to compensate for low cellular dUTPase activity for efficient viral replication.
Purification and properties of the deoxyuridine triphosphate nucleotidohydrolase enzyme derived from HeLa S3 cells. Comparison to a distinct dUTP nucleotidohydrolase induced in herpes simplex virus-infected HeLa S3 cells.
[The relationship between gene function and virulence in alpha-herpesviruses]
HIV Infections
Expression and cytoplasmic localisation of deoxyuridine triphosphate pyrophosphatase encoded by a human endogenous retrovirus.
Structure/function analysis of a dUTPase: catalytic mechanism of a potential chemotherapeutic target.
Hodgkin Disease
Expression of viral and human dUTPase in Epstein-Barr virus-associated diseases.
Hypertension
Monocyte-released HERV-K dUTPase engages TLR4 and MCAM causing endothelial mesenchymal transition.
Hypertension, Pulmonary
Monocyte-released HERV-K dUTPase engages TLR4 and MCAM causing endothelial mesenchymal transition.
Upregulation of HERV-K is Linked to Immunity and Inflammation in Pulmonary Arterial Hypertension.
Infections
African swine fever virus dUTPase is a highly specific enzyme required for efficient replication in swine macrophages.
Analysis of cyclin-dependent kinase activity after herpes simplex virus type 2 infection.
Bacillus subtilis deoxyuridinetriphosphatase and its bacteriophage PBS2-induced inhibitor.
Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism.
Human herpesviruses-encoded dUTPases: a family of proteins that modulate dendritic cell function and innate immunity.
Identification and characterization of a baculovirus structural protein, VP1054, required for nucleocapsid formation.
Identification and characterization of duck enteritis virus dUTPase gene.
Immunological parameters in goats experimentally infected with SRLV genotype E, strain Roccaverano.
Inhibition of phosphorylation of cellular dUTP nucleotidohydrolase as a consequence of herpes simplex virus infection.
Insights into the molecular and biological features of the dUTPase-related gene of bovine immunodeficiency virus.
Murine cytomegalovirus M72 promotes acute virus replication in vivo and is a substrate of the TRiC/CCT complex.
New dUTPase and dUDPase activites after infection of Escherichia coli by T2 bacteriophage.
Nuclear-export-signal-dependent protein translocation of dUTPase encoded by Singapore grouper iridovirus.
Purification and properties of the deoxyuridine triphosphate nucleotidohydrolase enzyme derived from HeLa S3 cells. Comparison to a distinct dUTP nucleotidohydrolase induced in herpes simplex virus-infected HeLa S3 cells.
Structural Insight into African Swine Fever Virus dUTPase Reveals a Novel Folding Pattern in the dUTPase Family.
The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection.
The EBV-encoded dUTPase activates NF-kappa B through the TLR2 and MyD88-dependent signaling pathway.
The properties of a bacteriophage T5 mutant unable to induce deoxyuridine 5'-triphosphate nucleotidohydrolase. Synthesis of uracil-containing T5 deoxyribonucleic acid.
Infectious Mononucleosis
Expression of viral and human dUTPase in Epstein-Barr virus-associated diseases.
Influenza in Birds
Live vaccination with an H5-hemagglutinin-expressing infectious laryngotracheitis virus recombinant protects chickens against different highly pathogenic avian influenza viruses of the H5 subtype.
Leukemia
Human deoxyuridine triphosphate nucleotidohydrolase. Purification and characterization of the deoxyuridine triphosphate nucleotidohydrolase from acute lymphocytic leukemia.
Leukemia, Lymphoid
Human deoxyuridine triphosphate nucleotidohydrolase. Purification and characterization of the deoxyuridine triphosphate nucleotidohydrolase from acute lymphocytic leukemia.
Leukoplakia, Hairy
Expression of viral and human dUTPase in Epstein-Barr virus-associated diseases.
Lung Neoplasms
A randomized, phase 2 study of deoxyuridine triphosphatase inhibitor, TAS-114, in combination with S-1 versus S-1 alone in patients with advanced non-small-cell lung cancer.
A tyrosine kinase inhibitor, beta-hydroxyisovalerylshikonin, induced apoptosis in human lung cancer DMS114 cells through reduction of dUTP nucleotidohydrolase activity.
Inhibition of dUTPase Induces Synthetic Lethality with Thymidylate Synthase-Targeted Therapies in Non-Small Cell Lung Cancer.
Malaria
Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors.
Functional genetic evaluation of DNA house-cleaning enzymes in the malaria parasite: dUTPase and Ap4AH are essential in Plasmodium berghei but ITPase and NDH are dispensable.
Keeping Uracil Out of DNA: Physiological Role, Structure and Catalytic Mechanism of dUTPases.
Kinetic and thermodynamic characterization of dUTP hydrolysis by Plasmodium falciparum dUTPase.
Melanoma
Monocyte-released HERV-K dUTPase engages TLR4 and MCAM causing endothelial mesenchymal transition.
Meningioma
Immunohistochemical detection of dUTPase in intracranial tumors.
Myxoma
The genome of swinepox virus.
Nasopharyngeal Carcinoma
A new lytic antibody, 7D6, detects Epstein-Barr virus dUTPase in nonkeratinizing undifferentiated nasopharyngeal carcinomas.
Expression of viral and human dUTPase in Epstein-Barr virus-associated diseases.
Neoplasm Metastasis
Expression of deoxyuridine triphosphatase (dUTPase) in colorectal tumours.
Higher expression of deoxyuridine triphosphatase (dUTPase) may predict the metastasis potential of colorectal cancer.
Neoplasms
A Human Endogenous Retrovirus K dUTPase Triggers a T(H)1, T(H)17 Cytokine Response: Does It Have a Role in Psoriasis?
A multicenter phase II study of TAS-114 in combination with S-1 in patients with pretreated advanced gastric cancer (EPOC1604).
Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase.
ATP-Linked Chimeric Nucleotide as a Specific Luminescence Reporter of Deoxyuridine Triphosphatase.
Backbone nuclear magnetic resonance assignment of human deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase).
Characterization of an integrated, endogenous mouse mammary tumor virus-like (MMTV) betaretrovirus genome in a black Syrian hamster (Mesocricetus auratus).
Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331.
Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells.
Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions.
dUTP nucleotidohydrolase isoform expression in normal and neoplastic tissues: association with survival and response to 5-fluorouracil in colorectal cancer.
dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA-repair-defective human cancer cells.
Expression and purification of the mouse mammary tumor virus gag-pro transframe protein p30 and characterization of its dUTPase activity.
Expression of deoxyuridine triphosphatase (dUTPase) in colorectal tumours.
Expression of viral and human dUTPase in Epstein-Barr virus-associated diseases.
First-in-human phase 1 study of novel dUTPase inhibitor TAS-114 in combination with S-1 in Japanese patients with advanced solid tumors.
Higher expression of deoxyuridine triphosphatase (dUTPase) may predict the metastasis potential of colorectal cancer.
Identification of potential pharmacogenomic markers of clinical efficacy of 5-fluorouracil in colorectal cancer.
Identification of sequence determinants of human nuclear dUTPase isoform localization.
Immunohistochemical detection of dUTPase in intracranial tumors.
Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase.
Inhibition of dUTPase Induces Synthetic Lethality with Thymidylate Synthase-Targeted Therapies in Non-Small Cell Lung Cancer.
Inhibition of the proliferation of human cancer cells in-vitro by substrate-analogous inhibitors of dUTPase.
Keeping Uracil Out of DNA: Physiological Role, Structure and Catalytic Mechanism of dUTPases.
New Challenges and Inspired Answers for Anticancer Drug Discovery and Development.
Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil.
Novel opportunities for thymidylate metabolism as a therapeutic target.
Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage.
Role of Microglia Autophagy in Microglia Activation After Traumatic Brain Injury.
Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition.
Structural insights into the mechanism defining substrate affinity in Arabidopsis thaliana dUTPase: the role of tryptophan 93 in ligand orientation.
Structural model of human dUTPase in complex with a novel proteinaceous inhibitor.
Targeting nucleotide metabolism enhances the efficacy of anthracyclines and anti-metabolites in triple-negative breast cancer.
TAS-114, a First-in-Class Dual dUTPase/DPD Inhibitor, Demonstrates Potential to Improve Therapeutic Efficacy of Fluoropyrimidine-Based Chemotherapy.
The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition.
The action of Pdcd4 may be cell type specific: evidence that reduction of dUTPase levels might contribute to its tumor suppressor activity in Bon-1 cells.
The contribution of DNA base damage to human cancer is modulated by the base excision repair interaction network.
The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells.
The protein p30, encoded at the gag-pro junction of mouse mammary tumor virus, is a dUTPase fused with a nucleocapsid protein.
The role of deoxyuridine triphosphate nucleotidohydrolase, uracil-DNA glycosylase, and DNA polymerase alpha in the metabolism of FUdR in human tumor cells.
The role of dUTPase and uracil-DNA repair in cancer chemotherapy.
Neuroblastoma
Phosphorylation of herpes simplex virus 1 dUTPase upregulated viral dUTPase activity to compensate for low cellular dUTPase activity for efficient viral replication.
Neuroinflammatory Diseases
Epstein-Barr Virus dUTPase Induces Neuroinflammatory Mediators: Implications for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
Oligodendroglioma
Immunohistochemical detection of dUTPase in intracranial tumors.
Osteosarcoma
Combining Non-reducing SDS-PAGE Analysis and Chemical Crosslinking to Detect Multimeric Complexes Stabilized by Disulfide Linkages in Mammalian Cells in Culture.
Persistent Infection
The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Human deoxyuridine triphosphate nucleotidohydrolase. Purification and characterization of the deoxyuridine triphosphate nucleotidohydrolase from acute lymphocytic leukemia.
Pseudorabies
Identification and characterization of pseudorabies virus dUTPase.
Pseudorabies Virus dUTPase UL50 Induces Lysosomal Degradation of Type I Interferon Receptor 1 and Antagonizes the Alpha Interferon Response.
The UL49.5 gene of pseudorabies virus codes for an O-glycosylated structural protein of the viral envelope.
Psoriasis
A Human Endogenous Retrovirus K dUTPase Triggers a T(H)1, T(H)17 Cytokine Response: Does It Have a Role in Psoriasis?
Haplotype sharing analysis identifies a retroviral dUTPase as candidate susceptibility gene for psoriasis.
Protective effect of human endogenous retrovirus K dUTPase variants on psoriasis susceptibility.
Retinoblastoma
Identification of candidate growth-regulating genes that are overexpressed in late gestation fetal liver in the rat.
Sarcoma, Kaposi
Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) ORF54 encodes a functional dUTPase expressed in the lytic replication cycle.
Sarcoma, Yoshida
A new deoxyuridine-5'-triphosphatase in Yoshida sarcoma cells involved in deoxyuridine 5'-triphosphate metabolism.
Smallpox
The genome of swinepox virus.
Stomach Neoplasms
A multicenter phase II study of TAS-114 in combination with S-1 in patients with pretreated advanced gastric cancer (EPOC1604).
Loss of RUNX3 expression correlates with differentiation, nodal metastasis, and poor prognosis of gastric cancer.
Superinfection
Induction of a deoxyuridine triphosphate nucleotidohydrolase activity in Epstein-Barr virus-infected cells.
Tuberculosis
A Hidden Active Site in the Potential Drug Target Mycobacterium tuberculosis dUTPase Is Accessible through Small Amplitude Protein Conformational Changes.
Active site of mycobacterial dUTPase: structural characteristics and a built-in sensor.
Antimycobacterial activity of peptide conjugate of pyridopyrimidine derivative against Mycobacterium tuberculosis in a series of in vitro and in vivo models.
Cross-species inhibition of dUTPase via the Staphylococcal Stl protein perturbs dNTP pool and colony formation in Mycobacterium.
Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target.
Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism.
Enhanced Cellular Uptake of a New, in Silico Identified Antitubercular Candidate by Peptide Conjugation.
Keeping Uracil Out of DNA: Physiological Role, Structure and Catalytic Mechanism of dUTPases.
Molecular Modeling of Mycobacterium Tuberculosis dUTpase: Docking and Catalytic Mechanism Studies.
Structural insights into the mechanism defining substrate affinity in Arabidopsis thaliana dUTPase: the role of tryptophan 93 in ligand orientation.
The dUTPase enzyme is essential in Mycobacterium smegmatis.
Uterine Cervical Neoplasms
Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions.
Vaccinia
Effects of vaccinia virus uracil DNA glycosylase catalytic site and deoxyuridine triphosphatase deletion mutations individually and together on replication in active and quiescent cells and pathogenesis in mice.
Genomic analysis of a transposition-deletion variant of orf virus reveals a 3.3 kbp region of non-essential DNA.
Orf virus encodes a functional dUTPase gene.
Purification and characterization of the vaccinia virus deoxyuridine triphosphatase expressed in Escherichia coli.
Structures of vaccinia virus dUTPase and its nucleotide complexes.
The genome of swinepox virus.
Vaccinia virus encodes a functional dUTPase.
Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine.
Virus Diseases
Characterization and functional studies of fowl adenovirus 9 dUTPase.
Cloning and expression of the Epstein-Barr virus-encoded dUTPase: patients with acute, reactivated or chronic virus infection develop antibodies against the enzyme.
Inhibition of phosphorylation of cellular dUTP nucleotidohydrolase as a consequence of herpes simplex virus infection.
Vaccinia virus encodes a functional dUTPase.
Visna
"Hidden" dUTPase sequence in human immunodeficiency virus type 1 gp120.
Replication properties of dUTPase-deficient mutants of caprine and ovine lentiviruses.
The role of retroviral dUTPases in replication and virulence.
Visna virus dUTPase is dispensable for neuropathogenicity.