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(2E)-hexadecenal + semicarbazide
(2E)-hexadecenal semicarbazone
(2S,3R,4E)-2-ammonio-3-hydroxy-7-((2-oxo-2H-chromen-7-yl)oxy)hept-4-en-1-yl hydrogenphosphate
?
i.e. RBM77
-
-
?
(2S,3R,5E)-2-ammonio-3-hydroxy-7-((2-oxo-2H-chromen-7-yl)oxy)hept-5-en-1-yl hydrogenphosphate
?
i.e. RBM148
-
-
?
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled sphinganine 1-phosphate
phosphoethanolamine + 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled palmitaldehyde
-
i.e. BODIPY-label, allows fluorescent product detection by HPLC
major aldehyde product is confirmed by reaction with 2,4-dinitrophenylhydrazine
-
?
4D-Hydroxysphinganine 1-phosphate
Phosphoethanolamine + 2-hydroxyhexadecanal
7-nitrobenz-2-oxa-1,3-diazole-sphingosine 1-phosphate
phosphoethanolamine + 7-nitrobenz-2-oxa-1,3-diazole-hexadec-2-enal
boron dipyrromethene difluoride-sphingosine 1-phosphate
phosphoethanolamine + boron dipyrromethene difluoride-hexadec-2-enal
C17-sphinganine-1-phosphate
phosphoethanolamine + pentadecanal
-
-
-
-
?
D-(+)-erythro-dihydrosphingosine 1-phosphate
?
-
-
-
-
?
D-(+)-erythro-sphingosine 1-phosphate
phosphoethanolamine + (2E)-hexadecenal
dihydrosphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
?
Dihydrosphingosine 1-phosphonate
Aminoethylphosphonate + palmidaldehyde
eicosadihydrosphingosine 1-phosphate + H2O
hexadecanal + 2-(icosanoylamino)ethyl phosphate
-
-
-
?
omega-(7-nitro-2-1,3-benzoxadiazol-4-yl)-D-erythro-sphingosine 1-phosphate
phosphoethanolamine + omega-(7-nitro-2-1,3-benzoxadiazol-4-yl)-D-erythro-(2E)-hexadecenal
-
-
-
-
ir
phytosphingosine 1-phosphate
?
-
-
-
-
?
phytosphingosine-1-phosphate
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
sphingosine 1-phosphate
phosphoethanolamine + (2E)-hexadecenal
sphingosine 1-phosphate
phosphoethanolamine + hexadecanal
-
-
?
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
sphingosine-1-phosphate
phosphoethanolamine + (2E)-hexadecenal
-
-
-
-
ir
umbelliferone-labled sphinganine 1-phosphate
phosphoethanolamine + 3-[(2-oxo-2H-chromen-7-yl)oxy]propanal
additional information
?
-
(2E)-hexadecenal + semicarbazide
(2E)-hexadecenal semicarbazone
-
-
-
?
(2E)-hexadecenal + semicarbazide
(2E)-hexadecenal semicarbazone
-
-
-
?
4D-Hydroxysphinganine 1-phosphate
Phosphoethanolamine + 2-hydroxyhexadecanal
-
-
-
?
4D-Hydroxysphinganine 1-phosphate
Phosphoethanolamine + 2-hydroxyhexadecanal
-
-
-
?
4D-Hydroxysphinganine 1-phosphate
Phosphoethanolamine + 2-hydroxyhexadecanal
-
-
-
?
7-nitrobenz-2-oxa-1,3-diazole-sphingosine 1-phosphate
phosphoethanolamine + 7-nitrobenz-2-oxa-1,3-diazole-hexadec-2-enal
-
-
-
-
?
7-nitrobenz-2-oxa-1,3-diazole-sphingosine 1-phosphate
phosphoethanolamine + 7-nitrobenz-2-oxa-1,3-diazole-hexadec-2-enal
-
-
-
?
7-nitrobenz-2-oxa-1,3-diazole-sphingosine 1-phosphate
phosphoethanolamine + 7-nitrobenz-2-oxa-1,3-diazole-hexadec-2-enal
-
-
-
-
?
boron dipyrromethene difluoride-sphingosine 1-phosphate
phosphoethanolamine + boron dipyrromethene difluoride-hexadec-2-enal
-
-
-
-
?
boron dipyrromethene difluoride-sphingosine 1-phosphate
phosphoethanolamine + boron dipyrromethene difluoride-hexadec-2-enal
-
-
-
?
boron dipyrromethene difluoride-sphingosine 1-phosphate
phosphoethanolamine + boron dipyrromethene difluoride-hexadec-2-enal
-
-
-
-
?
D-(+)-erythro-sphingosine 1-phosphate
phosphoethanolamine + (2E)-hexadecenal
-
-
-
-
ir
D-(+)-erythro-sphingosine 1-phosphate
phosphoethanolamine + (2E)-hexadecenal
-
-
-
ir
D-(+)-erythro-sphingosine 1-phosphate
phosphoethanolamine + (2E)-hexadecenal
-
-
-
-
ir
D-erythrosphingosine
?
8% activity compared to sphinganine 1-phosphate
-
-
?
D-erythrosphingosine
?
8% activity compared to sphinganine 1-phosphate
-
-
?
Dihydrosphingosine 1-phosphonate
Aminoethylphosphonate + palmidaldehyde
-
-
-
-
?
Dihydrosphingosine 1-phosphonate
Aminoethylphosphonate + palmidaldehyde
-
-
-
-
?
Dihydrosphingosine 1-phosphonate
Aminoethylphosphonate + palmidaldehyde
-
-
-
-
?
Dihydrosphingosine 1-phosphonate
Aminoethylphosphonate + palmidaldehyde
-
1-deoxysphinganine 1-phosphonate
-
?
phytosphingosine-1-phosphate
?
-
-
-
-
?
phytosphingosine-1-phosphate
?
-
-
-
-
?
RBM13
?
-
-
-
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
dihydrosphingosine-1-phosphate
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
ir
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
ir
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
ir
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
ir
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
ir
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
ir
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
ir
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
dihydrosphingosine-1-phosphate
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
ir
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
D-erythro-(2S,3R)-sphinganine 1-phosphate
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
D-erythro-(2S,3R)-sphinganine 1-phosphate
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
D(+)-erythro-dihydrosphingosine-1-phosphate
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
dihydrosphingosine-1-phosphate
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
dihydrosphingosine-1-phosphate
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
erythro-DL-dihydrosphingosine 1-phosphate
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
erythro-sphinganine 1-phosphate
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
threo-dihydrosphingosine 1-phosphate
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
ir
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
D(+)-erythro-dihydrosphingosine-1-phosphate
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
dihydrosphingosine-1-phosphate
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
ir
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
dihydrosphingosine-1-phosphate
-
?
sphingosine 1-phosphate
phosphoethanolamine + (2E)-hexadecenal
-
-
-
-
?
sphingosine 1-phosphate
phosphoethanolamine + (2E)-hexadecenal
-
-
-
-
ir
sphingosine 1-phosphate
phosphoethanolamine + (2E)-hexadecenal
-
-
-
ir
sphingosine 1-phosphate
phosphoethanolamine + (2E)-hexadecenal
-
-
-
-
ir
sphingosine 1-phosphate
phosphoethanolamine + (2E)-hexadecenal
-
-
-
-
ir
sphingosine 1-phosphate
phosphoethanolamine + (2E)-hexadecenal
-
-
-
-
ir
sphingosine 1-phosphate
phosphoethanolamine + (2E)-hexadecenal
-
-
-
-
ir
sphingosine 1-phosphate
phosphoethanolamine + (2E)-hexadecenal
-
-
-
ir
sphingosine 1-phosphate
phosphoethanolamine + (2E)-hexadecenal
-
SPL from Symbiobacterium thermophilum degrades extracellular sphingosine 1-phosphate in vitro and in blood
-
-
?
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
?
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
ir
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
sphingenine-phosphate
-
?
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
sphingenine-phosphate
-
?
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
ir
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
pathway of sphingomyelin degradation, sphingosine 1-phosphate is an important element of signal transduction pathways that regulate cell proliferation and cell death
-
ir
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
ir
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
?
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
?
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
?
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
ir
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
sphingenine-phosphate
-
?
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
ir
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
?
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
ir
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
sphingenine-phosphate
-
?
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
?
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
sphingenine-phosphate
-
?
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
-
-
-
ir
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
sphingenine-phosphate
-
?
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
4t-sphingosine 1-phosphate
-
?
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
sphingenine-phosphate
-
?
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
-
sphingenine-phosphate
-
?
umbelliferone-labled sphinganine 1-phosphate
phosphoethanolamine + 3-[(2-oxo-2H-chromen-7-yl)oxy]propanal
-
-
-
-
?
umbelliferone-labled sphinganine 1-phosphate
phosphoethanolamine + 3-[(2-oxo-2H-chromen-7-yl)oxy]propanal
-
-
-
?
umbelliferone-labled sphinganine 1-phosphate
phosphoethanolamine + 3-[(2-oxo-2H-chromen-7-yl)oxy]propanal
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
critical role in maintenance of intestinal integrity and normal reproduction
-
?
additional information
?
-
-
metabolic pathways of the enzyme substrates
-
-
?
additional information
?
-
-
metabolic pathways of the enzyme substrates
-
-
?
additional information
?
-
-
acts on 1-phosphorylated derivatives of sphingoid bases, products are an aliphatic fatty aldehyde and phosphoethanolamine
-
?
additional information
?
-
-
metabolic pathways of the enzyme substrates
-
-
?
additional information
?
-
role in ceramide metabolism and cell fate
-
?
additional information
?
-
-
role in ceramide metabolism and cell fate
-
?
additional information
?
-
-
acts on 1-phosphorylated derivatives of sphingoid bases, products are an aliphatic fatty aldehyde and phosphoethanolamine
-
?
additional information
?
-
-
acts on 1-phosphorylated derivatives of sphingoid bases, products are an aliphatic fatty aldehyde and phosphoethanolamine
-
?
additional information
?
-
-
no substrate: sphinganine
-
?
additional information
?
-
-
metabolic pathways of the enzyme substrates
-
-
?
additional information
?
-
-
metabolic pathways of the enzyme substrates
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
phosphoethanolamine is characterized by various forms of chromatography
-
-
?
additional information
?
-
-
metabolic pathways of the enzyme substrates
-
-
?
additional information
?
-
-
enzyme is responsible for the ultimate step in sphingolipid breakdown, converting phosphorylated long chain bases into ethanolamine phosphate and fatty aldehyde
-
-
?
additional information
?
-
-
metabolic relationship between substrates and products of biosynthesis and degradation of sphingosine bases
-
-
?
additional information
?
-
-
enzyme catalyzes a rate-limiting step in sphingolipid catabolism
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
metabolic pathways of the enzyme substrates
-
-
?
additional information
?
-
-
metabolic pathways of the enzyme substrates
-
-
?
additional information
?
-
-
-
-
-
?
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(1R,2S,3R)-1-(1H,1'H-2,2'-biimidazol-4-yl)butane-1,2,3,4-tetraol
-
inhibitory to sphinganine 1-phosphate lyase. 53% decrease in circulating lymphocytes after 30 mg/kg oral dose
(1R,2S,3R)-1-(2-(1-benzyl-1H-1,2,4-triazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol
-
inhibitory to sphinganine 1-phosphate lyase. 41% decrease in circulating lymphocytes after 30 mg/kg oral dose
(1R,2S,3R)-1-(2-(thiazol-4-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol
-
inhibitory to sphinganine 1-phosphate lyase. 33% decrease in circulating lymphocytes after 30 mg/kg oral dose
(2R,3R)-2-azido-3-hydroxyoctadecyl phosphate
(2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
(2R,3S)-2-azido-3-hydroxyoctadecyl phosphate
(2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
(2S,3R)-2-azido-3-hydroxyoctadecyl phosphate
(2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
(2S,3S)-2-azido-3-hydroxyoctadecyl phosphate
(2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
(R)-1-benzyl-4-(3-methyl-4-(5-(trifluoromethyl)pyridin-2-yl)-piperazin-1-yl)phthalazine
-
-
(R)-1-benzyl-4-(3-methyl-4-(5-nitropyridin-2-yl)piperazin-1-yl)-phthalazine
-
-
(R)-1-benzyl-4-(4-(5-cyanopyridin-2-yl)-3-methylpiperazin-1-yl)phthalazine-6-carbonitrile
-
-
(R)-4-benzyl-1-(4-(5-cyanopyridin-2-yl)-3-methylpiperazin-1-yl)phthalazine-6-carbonitrile
-
-
(R)-6-(2-methyl-4-(4-phenethylphthalazin-1-yl)piperazin-1-yl)nicotinonitrile
-
-
(R)-6-(2-methyl-4-(4-phenylphthalazin-1-yl)piperazin-1-yl)-nicotinonitrile
-
-
(R)-6-(4-(4-benzyl-6-(trifluoromethyl)phthalazin-1-yl)-2-methylpiperazin-1-yl)nicotinonitrile
-
-
(R)-6-(4-(4-benzyl-6-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl)nicotinonitrile
-
-
(R)-6-(4-(4-benzyl-7-(trifluoromethyl)phthalazin-1-yl)-2-methylpiperazin-1-yl)nicotinonitrile
-
-
(R)-6-(4-(4-benzyl-7-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl)nicotinonitrile
-
-
(R)-6-(4-(4-benzylphthalazin-1-yl)-2-ethylpiperazin-1-yl)nicotinonitrile
-
-
(R)-6-(4-(4-benzylphthalazin-1-yl)-2-isopropylpiperazin-1-yl)-nicotinonitrile
-
-
(R)-6-(4-(4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl)-nicotinic acid
-
-
(R)-6-(4-(4-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl)-nicotinonitrile
-
-
(S)-6-(4-(4-benzylphthalazin-1-yl)-2-(hydroxymethyl)piperazin-1-yl)nicotinonitrile
-
-
1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone
-
inhibitory to sphinganine 1-phosphate lyase. 25% decrease in circulating lymphocytes after 30 mg/kg oral dose
1-benzyl-4-[(3R)-4-(5-cyanopyridin-2-yl)-3-methylpiperazin-1-yl]phthalazine-6-carbonitrile
-
-
1-deoxydihydrosphingosine 1-phosphonate
1-deoxysphinganine 1-phosphonate
1-desoxysphinganine 1-phosphonate
1-{5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-imidazol-2-yl}ethanone
-
when given overnight at 25 mg/l in drinking water, tetrahydroxybutylimidazole raises sphingosine 1-phosphate levels and reduces SPL activity
2-acetyl-4(5)-tetrahydroxybutyl imidazole
-
inhibitory. Following the oral administration of 10 and 100 mg/kg 2-acetyl-4(5)-tetrahydroxybutyl imidazole to male rats, 2-acetyl-4(5)-tetrahydroxybutyl imidazole is rapidly absorbed and reaches a plasma peak level at 1 h post-dosing. Splenic S1P increases and reaches the peak level at 24 h. Blood lymphocyte count decreases as the splenic S1P level increases. 2-Acetyl-4(5)-tetrahydroxybutyl imidazole plasma concentration is linked to splenic S1P concentration using an indirect model incorporated with a four-step signal transduction model. In turn, the S1P level is directly coupled with blood lymphocyte number
2-acetyl-4-(1R,2S,3R,4-tetrahydroxybutyl)-1H-imidazole
-
-
2-acetyl-4-(1R,2S,3R,4-tetrahydroxybutyl)-imidazole
2-acetyl-4-(tetrahydroxybutyl)imidazole
-
the enzyme is inhibited indirectly by 2-acetyl-4-(tetrahydroxybutyl)imidazole under conditions of vitamin B6 deficiency
2-acetyl-4-tetrahydroxybutyl-imidazole
2-acetyl-4-tetrahydroxybutylimidazole
2-vinyl dihydrosphingosine
2-vinyl sphinganine phosphate
-
50% inhibition at 0.0024 mM
2-vinyldihydro-sphingosine 1-phosphate
2-vinyldihydrosphingosine 1-phosphate
2-vinylsphinganine 1-phosphate
-
-
2D,3L-sphinganine-phosphate
-
competitive
4-amino-N-[4-(1H-imidazol-1-yl)benzyl]-5-oxo-2-(piperidin-1-yl)-8-(tetrahydrofuran-2-ylmethyl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
-
-
4-chloromercuribenzoate
-
alkylates a cysteine residue
5-cyclopropyl-N-[2-[(4-ethoxy-2,5-dimethylbenzyl)amino]-1-(4-fluorophenyl)ethyl]-1,2-oxazole-3-carboxamide
-
-
5-cyclopropyl-N-[2-[(4-methoxy-2,5-dimethylbenzyl)amino]-1-phenylethyl]-1,2-oxazole-3-carboxamide
-
-
5-methoxy-N-[2-[(4-methoxy-2,5-dimethylbenzyl)amino]-1-phenylethyl]-1,2-oxazole-3-carboxamide
-
-
6-[(2R)-4-(4-benzyl-7-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrile
-
-
6-[(2R)-4-(4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrile
6-[4-(4-benzylphthalazin-1-yl)piperazin-1-yl]pyridine-3-carbonitrile
-
carboplatin
-
cells overexpressing enzyme show increased sensitivity
cisplatin
-
cells overexpressing enzyme show increased sensitivity, mediated by death kinase p38
deoxypyridoxin phosphate
-
inhibits
Deoxypyridoxine phosphate
deoxysphinganine 1-phosphonate
-
competitive
doxorubicin
-
cells overexpressing enzyme show increased sensitivity
ethyl 6-[(2R)-4-(4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carboxylate
-
FTY720 phosphate
-
less potent inhibitor than FTY720, effects only at 0.03 mM
fumonisin B1
-
10 mg/kg inhibits the expression of sphingosine 1-phosphate lyase
N,N-dimethyldodecylamine N-oxide
-
50% inhibition at 0.05 mM
N-(2-[[2,5-dimethyl-4-(2,2,2-trifluoroethoxy)benzyl]amino]-1-phenylethyl)-5-methyl-1,2-oxazole-3-carboxamide
-
-
N-(2-[[2,5-dimethyl-4-(pyridin-4-ylmethoxy)benzyl]amino]-1-phenylethyl)-5-methyl-1,2-oxazole-3-carboxamide
-
-
N-(2-[[4-methoxy-2-methyl-5-(trifluoromethyl)benzyl]amino]-1-phenylethyl)-5-methyl-1,2-oxazole-3-carboxamide
-
-
N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopentenyl)ethyl]octanamide
N-[1-(4-fluorophenyl)-2-[(4-methoxy-2,5-dimethylbenzyl)amino]ethyl]-5-methyl-1,2-oxazole-3-carboxamide
-
-
N-[1-[3-(4-amino-4-oxobutyl)phenyl]-2-[(4-methoxy-2,5-dimethylbenzyl)amino]ethyl]-5-methyl-1,2-oxazole-3-carboxamide
-
-
N-[1-[4-(3-hydroxyprop-1-yn-1-yl)phenyl]-2-[(4-methoxy-2,5-dimethylbenzyl)amino]ethyl]-5-methyl-1,2-oxazole-3-carboxamide
-
-
N-[1-[4-(4-amino-4-oxobutyl)phenyl]-2-[(4-methoxy-2,5-dimethylbenzyl)amino]ethyl]-5-methyl-1,2-oxazole-3-carboxamide
-
-
N-[2-[(4-butoxy-2,5-dimethylbenzyl)amino]-1-phenylethyl]-5-methyl-1,2-oxazole-3-carboxamide
-
-
N-[2-[(4-ethoxy-2,5-dimethylbenzyl)amino]-1-phenylethyl]-5-methyl-1,2-oxazole-3-carboxamide
-
-
N-[2-[(4-methoxy-2,5-dimethylbenzyl)amino]-1-(2-methoxyphenyl)ethyl]-5-methyl-1,2-oxazole-3-carboxamide
-
-
N-[2-[(4-methoxy-2,5-dimethylbenzyl)amino]-1-(3-methoxyphenyl)ethyl]-5-methyl-1,2-oxazole-3-carboxamide
-
-
N-[2-[(4-methoxy-2,5-dimethylbenzyl)amino]-1-(4-methoxyphenyl)ethyl]-5-methyl-1,2-oxazole-3-carboxamide
-
-
N-[2-[(4-methoxy-2,5-dimethylbenzyl)amino]-1-phenylethyl]-1,2-oxazole-3-carboxamide
-
-
N-[2-[(4-methoxy-2,5-dimethylbenzyl)amino]-1-phenylethyl]-3-methyl-1,2-oxazole-5-carboxamide
-
-
N-[2-[(4-methoxy-2,5-dimethylbenzyl)amino]-1-phenylethyl]-5-methyl-1,2-oxazole-3-carboxamide
-
-
N-[2-[(4-methoxy-2,5-dimethylbenzyl)amino]-1-[4-(pyridin-4-yl)phenyl]ethyl]-5-methyl-1,2-oxazole-3-carboxamide
-
-
N-[2-[(4-methoxybenzyl)amino]-1-phenylethyl]-5-methyl-1,2-oxazole-3-carboxamide
-
-
p-chloromercuribenzoate
-
complete inhibition
phosphopyridoxyl sphinganine 1-phosphate
phosphopyridoxyl sphingosine 1-phosphate
sphinganine 1-phosphonate
-
competitive inhibitor
sphinganine phosphate
-
2D,3L-isomer is a competitive inhibitor, but 2L,3L-isomer does not influence the enzyme
threo-dihydro-sphingosine 1-phosphate
[(4-benzyl-phthalazin-1-yl)-2-methylpiperazin-1-yl]-nicotinonitrile
[(4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitrile
-
[2-amino-2[2-(4-octylphenyl)ethyl]-3-hydroxypropyl]dihydrogen phosphate
(2R,3R)-2-azido-3-hydroxyoctadecyl phosphate
-
-
(2R,3R)-2-azido-3-hydroxyoctadecyl phosphate
-
-
(2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
-
(2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
-
(2R,3S)-2-azido-3-hydroxyoctadecyl phosphate
-
-
(2R,3S)-2-azido-3-hydroxyoctadecyl phosphate
-
-
(2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
-
(2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
-
(2S,3R)-2-azido-3-hydroxyoctadecyl phosphate
-
-
(2S,3R)-2-azido-3-hydroxyoctadecyl phosphate
-
-
(2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
-
(2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
-
(2S,3S)-2-azido-3-hydroxyoctadecyl phosphate
-
-
(2S,3S)-2-azido-3-hydroxyoctadecyl phosphate
-
-
(2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
-
(2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
-
1-deoxydihydrosphingosine 1-phosphonate
-
-
1-deoxydihydrosphingosine 1-phosphonate
-
competitive inhibitor
1-deoxydihydrosphingosine 1-phosphonate
-
-
1-deoxydihydrosphingosine 1-phosphonate
-
-
1-deoxydihydrosphingosine 1-phosphonate
-
-
1-deoxysphinganine 1-phosphonate
-
-
1-deoxysphinganine 1-phosphonate
-
-
1-desoxysphinganine 1-phosphonate
-
competitive inhibitor
1-desoxysphinganine 1-phosphonate
competitive inhibitor
1-desoxysphinganine 1-phosphonate
-
competitive inhibitor
2-acetyl-4-(1R,2S,3R,4-tetrahydroxybutyl)-imidazole
-
-
2-acetyl-4-(1R,2S,3R,4-tetrahydroxybutyl)-imidazole
-
2-acetyl-4-(1R,2S,3R,4-tetrahydroxybutyl)-imidazole
-
-
2-acetyl-4-tetrahydroxybutyl-imidazole
-
-
2-acetyl-4-tetrahydroxybutyl-imidazole
-
-
2-acetyl-4-tetrahydroxybutyl-imidazole
-
-
2-acetyl-4-tetrahydroxybutyl-imidazole
-
-
2-acetyl-4-tetrahydroxybutylimidazole
-
-
2-acetyl-4-tetrahydroxybutylimidazole
-
-
2-acetyl-4-tetrahydroxybutylimidazole
-
-
2-acetyl-4-tetrahydroxybutylimidazole
-
2-acetyl-4-tetrahydroxybutylimidazole
-
-
2-acetyl-4-tetrahydroxybutylimidazole
-
-
2-acetyl-4-tetrahydroxybutylimidazole
-
-
2-acetyl-4-tetrahydroxybutylimidazole
-
-
2-acetyl-4-tetrahydroxybutylimidazole
-
2-vinyl dihydrosphingosine
-
-
2-vinyl dihydrosphingosine
-
2-vinyl dihydrosphingosine
-
-
2-vinyldihydro-sphingosine 1-phosphate
-
-
2-vinyldihydro-sphingosine 1-phosphate
-
-
2-vinyldihydro-sphingosine 1-phosphate
-
-
2-vinyldihydro-sphingosine 1-phosphate
-
-
2-vinyldihydrosphingosine 1-phosphate
-
-
2-vinyldihydrosphingosine 1-phosphate
-
-
4'-deoxypyridoxine
-
a pyridoxal 5'-phosphate analog
4'-deoxypyridoxine
a pyridoxal 5'-phosphate analog
4'-deoxypyridoxine
-
a pyridoxal 5-phosphate analog
4-deoxypyridoxine
-
-
6-[(2R)-4-(4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrile
-
-
6-[(2R)-4-(4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrile
-
bisulfite
-
-
Ca2+
-
-
cyanide
-
-
cysteine
-
-
deoxypyridoxine
-
competitive inhibitor
deoxypyridoxine
-
competitive inhibitor
deoxypyridoxine
-
competitive inhibitor
deoxypyridoxine
-
competitive inhibitor
deoxypyridoxine
-
competitive inhibitor
Deoxypyridoxine phosphate
-
-
Deoxypyridoxine phosphate
-
50% inhibition at a concentration of 1.5 mM
FTY720
-
-
FTY720
-
in vitro inhibition of enzyme, effects occurring from 300 nM concentrations on, maximal effects at 0.03 mM
FTY720
-
inhibits at 0.03 mM
FTY720
-
also called fingolimod
FTY720
-
in vivo enzyme inhibition concommitantly with lymphopenia, neither enzyme gene expression nor tissue enzyme protein expression is affected by inhibior
FTY720
-
40% inhibition at 0.03 mM
FTY720
-
produces an 82% inhibition at equimolar concentration with C17-sphinganine-1-phosphate
FTY720
-
also called fingolimod
FTY720
-
also called fingolimod
FTY720
-
also called fingolimod
iodoacetamide
-
alkylates a cysteine residue
iodoacetamide
-
complete inhibition
LX2931
-
-
N-ethylmaleimide
-
alkylates a cysteine residue
N-ethylmaleimide
-
complete inhibition
N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopentenyl)ethyl]octanamide
-
-
N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopentenyl)ethyl]octanamide
-
N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopentenyl)ethyl]octanamide
-
-
phosphopyridoxyl sphinganine 1-phosphate
-
-
phosphopyridoxyl sphinganine 1-phosphate
-
-
phosphopyridoxyl sphingosine 1-phosphate
-
-
phosphopyridoxyl sphingosine 1-phosphate
-
-
Semicarbazide
-
-
Semicarbazide
-
nonspecific SPL inhibitor, reduces SPL activity in vitro by about 70% at 2 mM
threo-dihydro-sphingosine 1-phosphate
-
-
threo-dihydro-sphingosine 1-phosphate
-
-
threo-dihydro-sphingosine 1-phosphate
-
-
threo-dihydro-sphingosine 1-phosphate
-
-
Zn2+
-
-
[(4-benzyl-phthalazin-1-yl)-2-methylpiperazin-1-yl]-nicotinonitrile
-
-
[(4-benzyl-phthalazin-1-yl)-2-methylpiperazin-1-yl]-nicotinonitrile
-
-
[2-amino-2[2-(4-octylphenyl)ethyl]-3-hydroxypropyl]dihydrogen phosphate
-
-
[2-amino-2[2-(4-octylphenyl)ethyl]-3-hydroxypropyl]dihydrogen phosphate
-
[2-amino-2[2-(4-octylphenyl)ethyl]-3-hydroxypropyl]dihydrogen phosphate
-
-
additional information
-
not inhibited by D-erythro-sphingosine
-
additional information
-
not inhibited by D-erythro-sphingosine
-
additional information
-
overexpression of enzyme, no change in sensitivity to vincristine, chlorambucil
-
additional information
-
not inhibited by (S)-FTY720P
-
additional information
-
enzyme is sensitive toward neutral detergents
-
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0.0243 - 0.0283
(2R,3R)-2-azido-3-hydroxyoctadecyl phosphate
0.0117 - 0.0229
(2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
0.0108 - 0.025
(2R,3S)-2-azido-3-hydroxyoctadecyl phosphate
0.0052 - 0.0138
(2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
0.0257
(2S,3R)-2-azido-3-hydroxyoctadecyl phosphate
0.0101 - 0.0129
(2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
0.0218 - 0.0272
(2S,3S)-2-azido-3-hydroxyoctadecyl phosphate
0.016 - 0.0288
(2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
0.03
(R)-1-benzyl-4-(3-methyl-4-(5-(trifluoromethyl)pyridin-2-yl)-piperazin-1-yl)phthalazine
Homo sapiens
at pH 7.4 and 25°C
-
0.00074
(R)-1-benzyl-4-(3-methyl-4-(5-nitropyridin-2-yl)piperazin-1-yl)-phthalazine
Homo sapiens
at pH 7.4 and 25°C
-
0.000024
(R)-1-benzyl-4-(4-(5-cyanopyridin-2-yl)-3-methylpiperazin-1-yl)phthalazine-6-carbonitrile
Homo sapiens
at pH 7.4 and 25°C
-
0.0013
(R)-4-benzyl-1-(4-(5-cyanopyridin-2-yl)-3-methylpiperazin-1-yl)phthalazine-6-carbonitrile
Homo sapiens
at pH 7.4 and 25°C
-
0.03
(R)-6-(2-methyl-4-(4-phenethylphthalazin-1-yl)piperazin-1-yl)nicotinonitrile
Homo sapiens
at pH 7.4 and 25°C
-
0.03
(R)-6-(2-methyl-4-(4-phenylphthalazin-1-yl)piperazin-1-yl)-nicotinonitrile
Homo sapiens
IC50 above 0.03 mM, at pH 7.4 and 25°C
-
0.012
(R)-6-(4-(4-benzyl-6-(trifluoromethyl)phthalazin-1-yl)-2-methylpiperazin-1-yl)nicotinonitrile
Homo sapiens
at pH 7.4 and 25°C
-
0.0023
(R)-6-(4-(4-benzyl-6-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl)nicotinonitrile
Homo sapiens
at pH 7.4 and 25°C
-
0.0001
(R)-6-(4-(4-benzyl-7-(trifluoromethyl)phthalazin-1-yl)-2-methylpiperazin-1-yl)nicotinonitrile
Homo sapiens
at pH 7.4 and 25°C
-
0.00021
(R)-6-(4-(4-benzyl-7-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl)nicotinonitrile
Homo sapiens
at pH 7.4 and 25°C
-
0.0017
(R)-6-(4-(4-benzylphthalazin-1-yl)-2-ethylpiperazin-1-yl)nicotinonitrile
Homo sapiens
at pH 7.4 and 25°C
-
0.0025
(R)-6-(4-(4-benzylphthalazin-1-yl)-2-isopropylpiperazin-1-yl)-nicotinonitrile
Homo sapiens
at pH 7.4 and 25°C
-
0.03
(R)-6-(4-(4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl)-nicotinic acid, (R)-6-(4-(4-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl)-nicotinonitrile
Homo sapiens
IC50 above 0.03 mM, at pH 7.4 and 25°C
-
0.03
(R)-6-(4-(4-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl)-nicotinonitrile
Homo sapiens
-
IC50 above 0.03 mM, at pH 7.4 and 25°C
-
0.03
(S)-6-(4-(4-benzylphthalazin-1-yl)-2-(hydroxymethyl)piperazin-1-yl)nicotinonitrile
Homo sapiens
IC50 above 0.03 mM, at pH 7.4 and 25°C
-
0.0024
2-vinyldihydrosphingosine 1-phosphate
0.0024
2-vinylsphinganine 1-phosphate
Homo sapiens
-
pH and temperature not specified in the publication
0.0046
5-cyclopropyl-N-[2-[(4-ethoxy-2,5-dimethylbenzyl)amino]-1-(4-fluorophenyl)ethyl]-1,2-oxazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00073
5-cyclopropyl-N-[2-[(4-methoxy-2,5-dimethylbenzyl)amino]-1-phenylethyl]-1,2-oxazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0092
5-methoxy-N-[2-[(4-methoxy-2,5-dimethylbenzyl)amino]-1-phenylethyl]-1,2-oxazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0024 - 0.03
6-[(2R)-4-(4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrile
0.03
6-[4-(4-benzylphthalazin-1-yl)piperazin-1-yl]pyridine-3-carbonitrile
Homo sapiens
IC50 above 0.03 mM, at pH 7.4 and 25°C
0.0034
ethyl 6-[(2R)-4-(4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carboxylate
Homo sapiens
at pH 7.4 and 25°C
0.00059
N-(2-[[2,5-dimethyl-4-(2,2,2-trifluoroethoxy)benzyl]amino]-1-phenylethyl)-5-methyl-1,2-oxazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.001
N-(2-[[2,5-dimethyl-4-(pyridin-4-ylmethoxy)benzyl]amino]-1-phenylethyl)-5-methyl-1,2-oxazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0012
N-(2-[[4-methoxy-2-methyl-5-(trifluoromethyl)benzyl]amino]-1-phenylethyl)-5-methyl-1,2-oxazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00072
N-[1-(4-fluorophenyl)-2-[(4-methoxy-2,5-dimethylbenzyl)amino]ethyl]-5-methyl-1,2-oxazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0096
N-[1-[3-(4-amino-4-oxobutyl)phenyl]-2-[(4-methoxy-2,5-dimethylbenzyl)amino]ethyl]-5-methyl-1,2-oxazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00015
N-[1-[4-(3-hydroxyprop-1-yn-1-yl)phenyl]-2-[(4-methoxy-2,5-dimethylbenzyl)amino]ethyl]-5-methyl-1,2-oxazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00015
N-[1-[4-(4-amino-4-oxobutyl)phenyl]-2-[(4-methoxy-2,5-dimethylbenzyl)amino]ethyl]-5-methyl-1,2-oxazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00012
N-[2-[(4-butoxy-2,5-dimethylbenzyl)amino]-1-phenylethyl]-5-methyl-1,2-oxazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00026
N-[2-[(4-ethoxy-2,5-dimethylbenzyl)amino]-1-phenylethyl]-5-methyl-1,2-oxazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.05
N-[2-[(4-methoxy-2,5-dimethylbenzyl)amino]-1-(2-methoxyphenyl)ethyl]-5-methyl-1,2-oxazole-3-carboxamide
Homo sapiens
-
IC50 above 0.05 mM, pH and temperature not specified in the publication
0.0073
N-[2-[(4-methoxy-2,5-dimethylbenzyl)amino]-1-(3-methoxyphenyl)ethyl]-5-methyl-1,2-oxazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.005
N-[2-[(4-methoxy-2,5-dimethylbenzyl)amino]-1-(4-methoxyphenyl)ethyl]-5-methyl-1,2-oxazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0064
N-[2-[(4-methoxy-2,5-dimethylbenzyl)amino]-1-phenylethyl]-1,2-oxazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0038
N-[2-[(4-methoxy-2,5-dimethylbenzyl)amino]-1-phenylethyl]-3-methyl-1,2-oxazole-5-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.001
N-[2-[(4-methoxy-2,5-dimethylbenzyl)amino]-1-phenylethyl]-5-methyl-1,2-oxazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00085
N-[2-[(4-methoxy-2,5-dimethylbenzyl)amino]-1-[4-(pyridin-4-yl)phenyl]ethyl]-5-methyl-1,2-oxazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.05
N-[2-[(4-methoxybenzyl)amino]-1-phenylethyl]-5-methyl-1,2-oxazole-3-carboxamide
Homo sapiens
-
IC50 above 0.05 mM, pH and temperature not specified in the publication
0.047 - 0.0811
phosphopyridoxyl sphinganine 1-phosphate
0.0534 - 0.089
phosphopyridoxyl sphingosine 1-phosphate
0.0243
(2R,3R)-2-azido-3-hydroxyoctadecyl phosphate
Symbiobacterium thermophilum
-
at pH 10.6 and 37°C
0.0283
(2R,3R)-2-azido-3-hydroxyoctadecyl phosphate
Homo sapiens
-
at pH 10.6 and 37°C
0.0117
(2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
Symbiobacterium thermophilum
-
at pH 10.6 and 37°C
0.0229
(2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
Homo sapiens
-
at pH 10.6 and 37°C
0.0108
(2R,3S)-2-azido-3-hydroxyoctadecyl phosphate
Homo sapiens
-
at pH 10.6 and 37°C
0.025
(2R,3S)-2-azido-3-hydroxyoctadecyl phosphate
Symbiobacterium thermophilum
-
at pH 10.6 and 37°C
0.0052
(2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
Homo sapiens
-
at pH 10.6 and 37°C
0.0138
(2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
Symbiobacterium thermophilum
-
at pH 10.6 and 37°C
0.0257
(2S,3R)-2-azido-3-hydroxyoctadecyl phosphate
Homo sapiens
-
at pH 10.6 and 37°C
0.0257
(2S,3R)-2-azido-3-hydroxyoctadecyl phosphate
Symbiobacterium thermophilum
-
at pH 10.6 and 37°C
0.0101
(2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
Homo sapiens
-
at pH 10.6 and 37°C
0.0129
(2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
Symbiobacterium thermophilum
-
at pH 10.6 and 37°C
0.0218
(2S,3S)-2-azido-3-hydroxyoctadecyl phosphate
Homo sapiens
-
at pH 10.6 and 37°C
0.0272
(2S,3S)-2-azido-3-hydroxyoctadecyl phosphate
Symbiobacterium thermophilum
-
at pH 10.6 and 37°C
0.016
(2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
Symbiobacterium thermophilum
-
at pH 10.6 and 37°C
0.0288
(2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
Homo sapiens
-
at pH 10.6 and 37°C
0.0024
2-vinyldihydrosphingosine 1-phosphate
Homo sapiens
-
at pH 10.6 and 37°C
0.0024
2-vinyldihydrosphingosine 1-phosphate
Symbiobacterium thermophilum
-
at pH 10.6 and 37°C
0.0024
6-[(2R)-4-(4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrile
Homo sapiens
at pH 7.4 and 25°C
0.03
6-[(2R)-4-(4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrile
Homo sapiens
IC50 above 0.03 mM, at pH 7.4 and 25°C
0.0524
FTY720
Homo sapiens
-
pH and temperature not specified in the publication
0.0524
FTY720
Mus musculus
-
in 35 mM potassium phosphate buffer (pH 7.4), 0.6 mM EDTA, 70 mM sucrose, 36 mM sodium fluoride, 0.57 mM pyridoxal 5'-phosphate, at 37°C
0.0524
FTY720
Homo sapiens
-
at pH 10.6 and 37°C
0.0524
FTY720
Symbiobacterium thermophilum
-
at pH 10.6 and 37°C
0.047
phosphopyridoxyl sphinganine 1-phosphate
Symbiobacterium thermophilum
-
at pH 10.6 and 37°C
0.0811
phosphopyridoxyl sphinganine 1-phosphate
Homo sapiens
-
at pH 10.6 and 37°C
0.0534
phosphopyridoxyl sphingosine 1-phosphate
Symbiobacterium thermophilum
-
at pH 10.6 and 37°C
0.089
phosphopyridoxyl sphingosine 1-phosphate
Homo sapiens
-
at pH 10.6 and 37°C
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malfunction
-
downregulation/inhibition of SPL prevents premature cell cycle progression and mitotic death. Oral administration of an SPL inhibitor to mice prolonges their survival after exposure to a lethal dose (10Gy) of total body ionizing radiation
malfunction
-
hearts of heterozygous SPL knockout mice exhibit reduced SPL activity, elevated sphingosine 1-phosphate levels, smaller infarct size, and increased functional recovery after ischemia-reperfusion injury compared with littermate controls
malfunction
-
inhibition of S1PL with 4-deoxypyridoxine or knockdown of S1PL with siRNA increases intracellular sphingosine-1-phosphate 3fold, potentiates motility of HPAEC cells to extracellular sphingosine-1-phosphate or serum, and augments activated Rac1 as well as stimulates Rac1 and IQGAP1 translocation to the cell periphery
malfunction
-
enzyme inhibition causes protein-losing glomerulopathy due to podocyte dysfunction, skin irritation, and platelet activation and may also be associated with pathological alterations in other tissues such as lung, liver, thymus, and the red blood cell system
malfunction
-
enzyme inhibition causes protein-losing glomerulopathy due to podocyte dysfunction, skin irritation, and platelet activation and may also be associated with pathological alterations in other tissues such as lung, liver, thymus, and the red blood cell system
malfunction
-
enzyme-deficient mutants display impaired intracellular replication in murine macrophages (associated with an inability to evade the maturing phagosome)
malfunction
-
enzyme-deficient mutants display impaired intracellular replication in murine macrophages (associated with an inability to evade the maturing phagosome)
malfunction
-
the absence of the enzyme is associated with reduced NF-kappaB activation and atypical morphology of mitochondria
malfunction
-
the absence of the enzyme is associated with reduced NF-kappaB activation and atypical morphology of mitochondria
-
malfunction
-
enzyme-deficient mutants display impaired intracellular replication in murine macrophages (associated with an inability to evade the maturing phagosome)
-
metabolism
-
S1P lyase catalyzes the irreversible degradation of sphingosine 1-phosphate in the final step of sphingolipid metabolism
metabolism
-
sphingosine-1-phosphate lyase is a key enzyme of sphingolipid metabolism
metabolism
sphingosine-1-phosphate lyase is a key enzyme of sphingolipid metabolism
metabolism
sphingosine-1-phosphate lyase is a key enzyme of sphingolipid metabolism
metabolism
-
SPL functions as the exit gate of the sphingolipid metabolism
metabolism
-
SPL functions as the exit gate of the sphingolipid metabolism
metabolism
-
SPL functions as the exit gate of the sphingolipid metabolism
metabolism
-
SPL functions as the exit gate of the sphingolipid metabolism
physiological function
-
all S1PL-deficient genetic models used display lymphopenia, with sequestration of mature T-cells in the thymus and lymph nodes. In addition to the lymphoid phenotypes, S1PL KO mice also develop myeloid cell hyperplasia and significant lesions in the lung, heart, urinary tract, and bone, and have a markedly reduced life span. Complete absence of S1PL affects both maturation/development and egress of mature T cells from the thymus, whereas low level S1PL activity affects T-cell egress more than differentiation
physiological function
all S1PL-deficient genetic models used display lymphopenia, with sequestration of mature T-cells in the thymus and lymph nodes. In addition to the lymphoid phenotypes, S1PL KO mice also develop myeloid cell hyperplasia and significant lesions in the lung, heart, urinary tract, and bone, and have a markedly reduced life span. Complete absence of S1PL affects both maturation/development and egress of mature T cells from the thymus, whereas low level S1PL activity affects T-cell egress more than differentiation
physiological function
-
complete loss of SPL activity leads to upregulation of the antiapoptotic proteins Bcl-2 and Bcl-xL and consequently protects against apoptosis induced by chemotherapy and nutrient starvation but not against autophagy. Disruption of the gene encoding SPL is accompanied by concomitant accumulation of sphingosine and ceramide. SPL deficiency blocks the apoptotic cascade upstream of mitochondrial damage and leads to upregulation of the antiapoptotic proteins Bcl-2 and Bcl-xL without affecting the levels of the proapoptotic members Bax and Bid. Whereas starvation-induced apoptosis is reduced in Sgpl1-/- compared to Sgpl1+/+ cells, autophagy is similar in both cell types
physiological function
-
in mice with an inactive S1P lyase gene, in addition to the expected increase of sphingoid base phosphates, other sphingolipids including sphingosine, ceramide, and sphingomyelin are substantially elevated in the serum and/or liver. The S1P lyase deficiency results in changes in the levels of serum and liver lipids not directly within the sphingolipid pathway, including phospholipids, triacyglycerol, diacylglycerol, and cholesterol. Lipids in serum and lipid storage are elevated in liver, but adiposity is reduced in the S1P lyase-deficient mice. The S1P lyase deficiency causes widespread changes in the expression pattern of lipid metabolism genes, with a significant increase in the expression of PPAR, a master transcriptional regulator of lipid metabolism. The mRNA expression of the genes encoding the sphingosine kinases and S1P phosphatases, which directly control the levels of S1P, are not significantly changed in liver of the S1P lyase-deficient mice
physiological function
-
in mouse embryonic fibroblasts deficient in S1P lyase, sphingosine 1-phosphate and sphingosine concentrations are elevated about 6fold and 2fold, respectively. Resting intracellular Ca2+ is elevated and agonist-induced intracellular Ca2+ increases are augmented in S1P lyase-deficient cells both in the presence and absence of extracellular Ca2+. Intracellular Ca2+ increases and Ca2+ mobilization induced by the SERCA inhibitor, thapsigargin, are augmented. At least two cell types can be distinguished, one with a rapid and transient intracellular Ca2+-increase and the other with a slower and prolonged intracellular Ca2+ elevation upon stimulation with thapsigargin. Intracellular Ca2+ increases upon thapsigargin stimulation, reflecting overall Ca2+ release, by more than 50% in both rapidly and slowly responding S1P lyase-deficient cells
physiological function
-
incubation of lyase-deficient neurons with either sphingosine or S1P results in a similar elevation in cellular S1P, but only S1P addition to the culture medium induces apoptosis. This is not due to S1P acting on the S1P receptor but to hydrolysis of S1P to sphingosine that is phosphorylated by the cells. Although the cells produce S1P from both exogenously added sphingosine as well as sphingosine derived from exogenous S1P, the S1P from these two sources are not equivalent, because the former is primarily produced by SK1, whereas the latter is mainly formed by sphingosine kinase-2
physiological function
-
thymocyte development in SGPL1-deficient mice which exhibit postnatal discontinuation of early thymocytopoies is starting at 2 weeks after birth. SGPL-/- thymi show a loss of developing thymocytes in the thymic cortex between 2 and 4 weeks of age, whereas mature thymocytes accumulate in the medulla. Increased ceramide levels in the thymus of SGPL1-/- mice abrogates thymic development postnatally by enhanced thymocyte apoptosis and depletion of thymic ETP. Potentially therapeutic immunosuppression by SGPL1 inhibition should benefit from monitoring ceramides to prevent their increase to apoptosis-inducing levels
physiological function
-
in renal mesangial cells, endothelial cells, breast (MCF-7) and colon (HCT 116) carcinoma cells, wild type SPL from Symbiobacterium thermophilum disrupts MAPK phosphorylation stimulated by exogenous sphingosine 1-phosphate. Under in vivo conditions SPL from Symbiobacterium thermophilum inhibits tumor cell-induced angiogenesis as an sphingosine 1-phosphate-dependent process
physiological function
-
SPL contributes to oxidative stress by depleting sphingosine 1-phosphate pools available for cardioprotective signaling
physiological function
-
SPL is the final enzyme in the sphingolipid degradative pathway and an important regulator of sphingosine 1-phosphate as well as the levels of other sphingolipid intermediates which influence various aspects of cell growth, proliferation and death. SPL is necessary for maintaining lipid homeostasis and appropriate cell fate responses. SPL serves as a therapeutic target for immune modulation
physiological function
-
SPL is the final enzyme in the sphingolipid degradative pathway and an important regulator of sphingosine 1-phosphate as well as the levels of other sphingolipid intermediates which influence various aspects of cell growth, proliferation and death. SPL is necessary for maintaining lipid homeostasis and appropriate cell fate responses. SPL serves as a therapeutic target for immune modulation
physiological function
SPL is the final enzyme in the sphingolipid degradative pathway and an important regulator of sphingosine 1-phosphate as well as the levels of other sphingolipid intermediates which influence various aspects of cell growth, proliferation and death. SPL is necessary for maintaining lipid homeostasis and appropriate cell fate responses. SPL serves as a therapeutic target for immune modulation
physiological function
-
SPL modulates the kinetics of DNA repair, speed of recovery from G2 cell cycle arrest and the extent of apoptosis after ionizing radiation. SPL expression affects the Cdk1-cyclin B complex
physiological function
-
SPL plays a crucial role in the migration of T-cells from lymphoid tissues by maintaining the sphingosine 1-phosphate gradient necessary for T-cells to egress from the lymph nodes into the blood stream. SPL plays a central role in neutrophil egress from blood to tissues. SPL is a central and crucial regulator of lipid homeostasis. SPL activity is linked to an increase in CER levels in response to stress factors and is involved in apoptosis
physiological function
a myoblast sphingosine-1-phosphate lyase-knockdown cell accumulates intracellular and extracellular sphingosine-1-phosphate and fails to form myotubes under conditions that normally stimulate myogenic differentiation. Under differentiation conditions, knockdown cells also demonstrate delayed induction of myogenic microRNAs, miR-1, miR-206, and miR-486. Knockdown cells successfully differentiate when treated with an S1P1 agonist, S1P2 antagonist, and combination treatments, which also increase myogenic miRNA levels. Knockdown cells transfected with mimics for miR-1 or miR-206 also overcome the differentiation block
physiological function
-
in C4-2B and PC-3 cells, silencing of sphingosine 1-phosphate lyase enhances survival after irradiation or chemotherapy by decreasing expression of proteins involved in sensing and repairing DNA damage or apoptosis, respectively. Enforced expression of sphingosine 1-phosphate lyase sensitizes cancer cells to irradiation or docetaxel by tilting the ceramide/sphingosine 1-phosphate balance toward cell death
physiological function
-
inducible sphingosine-1-phosphate lyase knockout mice featuring partial reduction of sphingosine-1-phosphate lyase activity are viable but feature profound reduction of peripheral T cells, similar to the constitutive knockout mice. While thymic T cell development in these mice appears normal, mature T cells are retained in thymus and lymph nodes, leading to reduced T cell numbers in spleen and blood, with a skewing towards increased proportions of memory T cells and T regulatory cells. The inducible knockout mice are protected in experimental autoimmune encephalomyelitis. T cell immigration into the CNS is profoundly reduced
physiological function
-
silencing or inhibition of sphingosine-1-phosphate lyase with short interfering RNA or active site-directed inhibitors in cultured mammalian cells does not cause a relevant increase of sphingosine-1-phosphate in the cells. The addition of sphingosine to cultures of cell lines or primary cells provides a source of intracellular sphingosine-1-phosphate that is susceptible to degradation by the lyase and, hence, increases on inhibition or silencing of the enzyme
physiological function
-
sphingosine phosphate lyase knockdown via short hairpin RNA in embryonic stem cells shows a 5fold increase in cellular sphingosine 1-phosphate levels, increased proliferation rates and high expression of cell surface pluripotency markers SSEA1 and OCT4 compared to vector control cells. Knockdown cells show robust activation of STAT3 and a 10fold increase in S1P2 expression. Inhibition of S1P2 or STAT3 reverses the proliferation and pluripotency phenotypes of knockdown cells. Inhibition of S1P2 attenuates, in a dose-dependent fashion, the high levels of OCT4 and STAT3 activation. Knockdown cells are capable of generating embryoid bodies from which muscle stem cells, called satellite cells, can be isolated
physiological function
-
enzyme expression in mature T cells contributes to efficient thymic egress
physiological function
-
enzyme overexpression reduces cytokine-induced endoplasmic reticulum stress, regulates Ca2+ homeostasis and Bcl2-associated death promotor phosphorylation in INS1E cells, and protects against cytokine-mediated inhibition of cell proliferation and caspase-3 activation in insulin-secreting INS1E cells
physiological function
-
the enzyme plays a critical role in virulence and is required for intracellular survival
physiological function
-
the enzyme plays a critical role in virulence and is required for intracellular survival
physiological function
-
the enzyme plays a critical role in virulence and is required for intracellular survival
-
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Stoffel, W.; Lekim, D; Stich, G.
Distribution and properties of dihydrosphingosine-1-phosphate aldolase (Sphinganine-1-phosphate alkanal-lyase)
Hoppe-Seyler's Z. Physiol. Chem.
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Bos taurus, Wickerhamomyces ciferrii, Rattus norvegicus, Sus scrofa
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Chemistry and biochemistry of 1-desoxysphinganine 1-phosphonate (dihydrosphingosine-1-phosphonate)
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Rattus norvegicus, Tetrahymena pyriformis
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Canis lupus familiaris, Cavia porcellus, Homo sapiens, Platyrrhini, Mus musculus, Rattus norvegicus, Sus scrofa, Tetrahymena pyriformis
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Canis lupus familiaris, Homo sapiens
brenda
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The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase
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Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q221
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Homo sapiens (O95470), Homo sapiens
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Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum
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128
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2001
Dictyostelium discoideum (Q54RV9), Dictyostelium discoideum
brenda
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Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5'-phosphate binding domain exposed to the cytosol
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2004
Mus musculus
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Homo sapiens, Mus musculus
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Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38-dependent manner
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2005
Homo sapiens
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2007
Mus musculus
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2007
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S1P-lyase independent clearance of extracellular sphingosine 1-phosphate after dephosphorylation and cellular uptake
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2008
Homo sapiens
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Molecular and functional characterization of sphingosine-1-phosphate lyase homolog from higher plants
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2007
Oryza sativa, Arabidopsis thaliana (Q9C509)
-
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A rapid fluorescence assay for sphingosine-1-phosphate lyase enzyme activity
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Homo sapiens, Mus musculus
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Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer
Proc. Natl. Acad. Sci. USA
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2006
Homo sapiens, Mus musculus
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Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren
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13
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2007
Caenorhabditis elegans, Dictyostelium discoideum, Drosophila melanogaster, Homo sapiens, Leishmania major, Mus musculus, Rattus norvegicus
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Identifying key residues of sphinganine-1-phosphate lyase for function in vivo and in vitro
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283
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Saccharomyces cerevisiae (Q05567)
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Regulation of cell death by sphingosine 1-phosphate lyase
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380
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Homo sapiens
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Homo sapiens
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Mus musculus
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Mus musculus
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Mus musculus
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Mus musculus
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Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions
PLoS ONE
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Homo sapiens, Mus musculus (Q8R0X7), Mus musculus
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Rattus norvegicus
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Serra, M.; Saba, J.
Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function
Adv. Enzyme Regul.
50
349-362
2010
Homo sapiens, Rattus norvegicus, Mus musculus (Q8R0X7)
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Bandhuvula, P.; Honbo, N.; Wang, G.Y.; Jin, Z.Q.; Fyrst, H.; Zhang, M.; Borowsky, A.D.; Dillard, L.; Karliner, J.S.; Saba, J.D.
S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart
Am. J. Physiol. Heart Circ. Physiol.
300
H1753-H1761
2011
Mus musculus
brenda
Berdyshev, E.V.; Goya, J.; Gorshkova, I.; Prestwich, G.D.; Byun, H.S.; Bittman, R.; Natarajan, V.
Characterization of sphingosine-1-phosphate lyase activity by electrospray ionization-liquid chromatography/tandem mass spectrometry quantitation of (2E)-hexadecenal
Anal. Biochem.
408
12-18
2011
Mus musculus
brenda
Ito, H.; Yoshida, K.; Murakami, M.; Hagiwara, K.; Sasaki, N.; Kobayashi, M.; Takagi, A.; Kojima, T.; Sobue, S.; Suzuki, M.; Tamiya-Koizumi, K.; Nakamura, M.; Banno, Y.; Nozawa, Y.; Murate, T.
Heterogeneous sphingosine-1-phosphate lyase gene expression and its regulatory mechanism in human lung cancer cell lines
Biochim. Biophys. Acta
1811
119-128
2011
Homo sapiens
brenda
Kumar, A.; Oskouian, B.; Fyrst, H.; Zhang, M.; Paris, F.; Saba, J.D.
S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism
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2
e119
2011
Mus musculus
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Berdyshev, E.V.; Gorshkova, I.; Usatyuk, P.; Kalari, S.; Zhao, Y.; Pyne, N.J.; Pyne, S.; Sabbadini, R.A.; Garcia, J.G.; Natarajan, V.
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Homo sapiens
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Saccharomyces cerevisiae, Homo sapiens (O95470), Homo sapiens, Symbiobacterium thermophilum (Q67PY4), Symbiobacterium thermophilum
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Park, S.M.; Angel, C.E.; McIntosh, J.D.; Brooks, A.E.; Middleditch, M.; Chen, C.J.; Ruggiero, K.; Cebon, J.; Dunbar, P.R.
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Homo sapiens
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Homo sapiens
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Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis
PLoS ONE
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Mus musculus
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Homo sapiens
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Homo sapiens (O95470)
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Homo sapiens, Mus musculus
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Homo sapiens
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Homo sapiens, Symbiobacterium thermophilum
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Orally active 7-substituted [(4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis
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Mus musculus
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Burkholderia pseudomallei, Burkholderia thailandensis, Burkholderia pseudomallei K96243
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Oryza sativa
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The sphingosine-1-phosphate lyase (LegS2) contributes to the restriction of Legionella pneumophila in murine macrophages
PLoS ONE
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Legionella pneumophila, Legionella pneumophila JR32
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Schuemann, J.; Grevot, A.; Ledieu, D.; Wolf, A.; Schubart, A.; Piaia, A.; Sutter, E.; Cote, S.; Beerli, C.; Pognan, F.; Billich, A.; Moulin, P.; Walker, U.J.
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Mus musculus, Rattus norvegicus
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