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Information on EC 5.4.4.5 - 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase

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EC Tree
IUBMB Comments
The enzyme contains heme . The bifunctional enzyme from Aspergillus nidulans uses different heme domains to catalyse two separate reactions. Linoleic acid is oxidized within the N-terminal heme peroxidase domain to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (cf. EC 1.13.11.60, linoleate 8R-lipoxygenase), which is subsequently isomerized to (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate within the C-terminal P-450 heme thiolate domain .
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The enzyme appears in viruses and cellular organisms
Synonyms
5,8-LDS, 5,8-linoleate diol synthase, PpoA, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate
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PATHWAY SOURCE
PATHWAYS
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