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Information on EC 5.6.2.1 - DNA topoisomerase

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IUBMB Comments
These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.2 DNA topoisomerase (ATP-hydrolysing).
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining
Synonyms
topoisomerase, topoisomerase i, topo i, dna topoisomerase i, topoisomerase iv, dna topoisomerase, human topoisomerase i, topoisomerase 1, reverse gyrase, topoisomerase-i, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining
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