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Information on EC 7.1.1.1 - proton-translocating NAD(P)+ transhydrogenase

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IUBMB Comments
The enzyme is a membrane bound proton-translocating pyridine nucleotide transhydrogenase that couples the reversible reduction of NADP by NADH to an inward proton translocation across the membrane. In the bacterium Escherichia coli the enzyme provides a major source of cytosolic NADPH. Detoxification of reactive oxygen species in mitochondria by glutathione peroxidases depends on NADPH produced by this enzyme.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
Synonyms
H+-TH, H+-thase, H+-transhydrogenase, nicotinamide adenine dinucleotide H +-transhydrogenase, nicotinamide nucleotide transhydrogenase, NNT, pntA, PntAB, pntB, proton translocating nicotinamide nucleotide transhydrogenase, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
NADPH + NAD+ + H+[side 1] = NADP+ + NADH + H+[side 2]
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