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107364096
T1KH75; A0A1D8X822
49 kDa subunit, gene name
13 kDa differentiation-associated protein
-
-
-
-
AIF-homologous mitochondrion-associated inducer of death
-
alternative complex I
-
-
alternative NADH oxidoreductase
-
-
alternative NADH: ubiquinone oxidoreductase
-
-
alternative NADH:ubiquinone oxidoreductase
apoptosis-inducing factor 1
-
artificial mediator accepting pyridine nuclöeotide oxidoreductase
-
-
Cell adhesion protein SQM1
-
-
-
-
Cell death-regulatory protein GRIM-19
-
-
-
-
coenzyme Q reductase
-
-
-
-
complex I (electron transport chain)
-
-
-
-
complex I (mitochondrial electron transport)
-
-
-
-
complex I (NADH:Q1 oxidoreductase)
-
-
-
-
complex I dehydrogenase
-
-
-
-
dihydronicotinamide adenine dinucleotide-coenzyme Q reductase
-
-
-
-
DPNH-coenzyme Q reductase
-
-
-
-
DPNH-ubiquinone reductase
-
-
-
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EC 1.6.2.1
-
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formerly
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EC 1.6.5.3
-
-
formerly
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EC 1.6.99.3
-
-
formerly
-
electron transfer complex I
-
-
-
-
energy-converting NADPH:ubiquinone oxidoreductase
-
-
external alternative NAD(P)H dehydrogenase
-
-
Gene associated with retinoic-interferon-induced mortality 19 protein
-
-
-
-
Hypothetical protein Walter
-
-
-
-
Internal NADH dehydrogenase
mitochondrial electron transport complex 1
-
-
-
-
mitochondrial electron transport complex I
-
-
-
-
mitochondrial NADH dehydrogenase
-
-
mitochondrial NADH dehydrogenase complex
-
mitochondrial NADH:ubiquinone oxidoreductase
mitochondrial proton-pumping NADH-ubiquinone oxidoreductase
-
NADH coenzyme Q dehydrogenase
-
-
NADH coenzyme Q1 reductase
-
-
-
-
NADH dehydrogenase 1 alpha subcomplex 5
-
NDUFA5
NADH dehydrogenase subunit 5
-
-
NADH dehydrogenase [ubiquinone] 1
alpha subcomplex subunit 10
NADH-coenzyme Q oxidoreductase
-
-
-
-
NADH-coenzyme Q reductase
-
-
-
-
NADH-CoQ reductase
-
-
-
-
NADH-ferricyanide reductase
-
-
-
-
NADH-Q1 oxidoreductase
-
-
NADH-Q6 oxidoreductase
-
-
-
-
NADH-quinone (NADH-ferricyanide) reductase
-
-
NADH-quinone oxidoreductase
NADH-ubiquinone oxidoreductase
NADH-ubiquinone oxidoreductase (complex I)
-
-
NADH-ubiquinone reductase
NADH-ubiquinone-1 reductase
-
-
-
-
NADH: n-decylubiquinone oxidoreductase
-
-
NADH: ubiquinone oxidoreductase
-
-
NADH: ubiquinone reductase
-
-
NADH:caldariella quinone oxidoreductase
-
-
NADH:coenzyme Q oxidoreductase
-
-
NADH:CoQ1 oxidoreductase
-
-
NADH:cytochrome c reductase
-
-
NADH:DBQ oxidoreductase
-
-
NADH:external quinone reductase
-
-
NADH:HAR (III) reductase
-
-
NADH:quinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
NADH:ubiquinone oxidoreductase complex
-
-
-
-
NADH:ubiquinone-1 oxidoreductase
-
-
NADHubiquinone Q1 oxidoreductase
-
-
Ndh/NdhAtype II NADH:(mena)quinone oxidoreductase
-
-
nicotinamide adenine dinucleotide-ubiquinone oxidoreductase
-
-
NQR2
O67392; O67334; O66826; O66842; O66841; O66748; O67384; O67386; O67338; O67339; O67027; O67390; O67391
-
NuoA1
O67392; O67334; O66826; O66842; O66841; O66748; O67384; O67386; O67338; O67339; O67027; O67390; O67391
-
NuoB
O67333; O67334; O67335; O66841; O66748; O67336; O67338; O67339; O67340; O67341; O67342, O67392; O67334; O66826; O66842; O66841; O66748; O67384; O67386; O67338; O67339; O67027; O67390; O67391 -
NuoD1
O67392; O67334; O66826; O66842; O66841; O66748; O67384; O67386; O67338; O67339; O67027; O67390; O67391
-
NuoE
O67333; O67334; O67335; O66841; O66748; O67336; O67338; O67339; O67340; O67341; O67342, O67392; O67334; O66826; O66842; O66841; O66748; O67384; O67386; O67338; O67339; O67027; O67390; O67391 -
NuoF
O67333; O67334; O67335; O66841; O66748; O67336; O67338; O67339; O67340; O67341; O67342, O67392; O67334; O66826; O66842; O66841; O66748; O67384; O67386; O67338; O67339; O67027; O67390; O67391 -
NuoG
O67333; O67334; O67335; O66841; O66748; O67336; O67338; O67339; O67340; O67341; O67342, O67392; O67334; O66826; O66842; O66841; O66748; O67384; O67386; O67338; O67339; O67027; O67390; O67391 -
NuoH2
O67392; O67334; O66826; O66842; O66841; O66748; O67384; O67386; O67338; O67339; O67027; O67390; O67391
-
NuoI2
O67392; O67334; O66826; O66842; O66841; O66748; O67384; O67386; O67338; O67339; O67027; O67390; O67391
-
NuoJ1
O67333; O67334; O67335; O66841; O66748; O67336; O67338; O67339; O67340; O67341; O67342, O67392; O67334; O66826; O66842; O66841; O66748; O67384; O67386; O67338; O67339; O67027; O67390; O67391 -
NuoK1
O67333; O67334; O67335; O66841; O66748; O67336; O67338; O67339; O67340; O67341; O67342, O67392; O67334; O66826; O66842; O66841; O66748; O67384; O67386; O67338; O67339; O67027; O67390; O67391 -
NuoL2
O67392; O67334; O66826; O66842; O66841; O66748; O67384; O67386; O67338; O67339; O67027; O67390; O67391
-
NuoM2
O67392; O67334; O66826; O66842; O66841; O66748; O67384; O67386; O67338; O67339; O67027; O67390; O67391
-
NuoN2
O67392; O67334; O66826; O66842; O66841; O66748; O67384; O67386; O67338; O67339; O67027; O67390; O67391
-
proton-pumping NADH-ubiquinone oxidoreductase
proton-pumping NADH:ubiquinone oxidoreductase
proton-translocating NADH-quinone oxidoreductase
-
-
proton-translocating NADH: ubiquinone oxidoreductase
-
-
proton-translocating NADH:ubiquinone oxidoreductase
-
-
PSST
T1KH75; A0A1D8X822
-
reduced nicotinamide adenine dinucleotide-coenzyme Q reductase
-
-
-
-
reductase, ubiquinone
-
-
-
-
respiratory chain complex I
type 2 NADH:quinone oxidoreductase
-
-
type I dehydrogenase
-
-
-
-
type I NADH dehydrogenase
type II NADH dehydrogenase
type II NADH-quinone oxidoreductase
-
-
type II NADH:dehydrogenase
-
-
type II NADH:quinone oxidoreductase
-
-
type-2 NADH:quinone oxidoreductase
-
-
type-II calcium-dependent NADH dehydrogenase
-
type-II NADH dehydrogenase
-
-
type-II NADH dehydrogenase TgNDH2-I
-
-
type-II NADH-menaquinone oxidoreductase
-
-
ubiquinone reductase
-
-
-
-
Ubiquinone-binding protein
-
-
-
-
alternative NADH:ubiquinone oxidoreductase
-
-
alternative NADH:ubiquinone oxidoreductase
-
-
-
complex 1
-
-
complex I
-
-
complex I
-
-
658174, 671827, 671882, 672013, 672126, 672129, 672176, 672291, 672597, 674694, 675345, 676868, 696270, 696288, 696312, 696510, 696745, 711290, 714281, 714993, 724383, 724564, 725003, 725491
complex I
Chlamydomonas sp.
-
-
complex I
-
-
659331, 672041, 672043, 672349, 673620, 674624, 675494, 690948, 696380, 698799, 725005, 725142, 725443, 725517
complex I
-
in mitochondria
complex I
-
in mitochondria
-
complex I
-
-
672974, 675345, 691039, 691049, 692447, 692992, 693815, 694192, 694352, 694936, 695189, 726174
complex I
-
in mitochondria
complex I
-
-
657845, 659387, 659946, 690886, 691037, 691058, 692231, 693532, 693720, 693745, 693773, 695063
Internal NADH dehydrogenase
-
-
-
-
Internal NADH dehydrogenase
-
-
mitochondrial complex I
-
mitochondrial complex I
-
-
mitochondrial NADH:ubiquinone oxidoreductase
-
-
mitochondrial NADH:ubiquinone oxidoreductase
-
-
Nad1
-
NADH dehydrogenase
-
-
NADH-CoQ oxidoreductase
-
-
-
-
NADH-CoQ oxidoreductase
-
-
NADH-CoQ oxidoreductase
-
-
NADH-quinone oxidoreductase
-
-
NADH-quinone oxidoreductase
-
-
NADH-quinone oxidoreductase
-
-
NADH-quinone reductase
-
-
-
-
NADH-quinone reductase
-
-
NADH-ubiquinone oxidoreductase
-
-
-
-
NADH-ubiquinone oxidoreductase
-
-
NADH-ubiquinone oxidoreductase
-
NADH-ubiquinone oxidoreductase
-
-
NADH-ubiquinone oxidoreductase
-
-
NADH-ubiquinone oxidoreductase
-
-
NADH-ubiquinone oxidoreductase
-
-
NADH-ubiquinone oxidoreductase
-
-
NADH-ubiquinone oxidoreductase
-
-
NADH-ubiquinone oxidoreductase
-
-
NADH-ubiquinone oxidoreductase
Vitis vinifera x Vitis vinifera
-
-
NADH-ubiquinone reductase
-
-
-
-
NADH-ubiquinone reductase
-
-
NADH:HAR reductase
-
-
NADH:Q oxidoreductase
-
-
-
-
NADH:Q oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
658135, 658174, 671827, 671882, 672126, 672291, 672348, 674694, 675345, 676868, 696288, 696312, 696745, 724383, 725003, 725491
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
Chlamydomonas sp.
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
659331, 671940, 672008, 672041, 672349, 674624, 675494, 690948, 696147, 724310, 725142
NADH:ubiquinone oxidoreductase
-
-
-
NADH:ubiquinone oxidoreductase
-
-
-
NADH:ubiquinone oxidoreductase
-
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase
-
-
ND1
-
-
NDH
-
-
NDH-1
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-
NDH-1
-
proton-pumping NADH-ubiquinone oxidoreductase
NDH-1
-
the NuoG subunit of the type I NADH dehydrogenase
NDH-1
-
the NuoG subunit of the type I NADH dehydrogenase
-
NDH-1
-
prokaryotic complex I homolog
NDH-2
-
-
NDH-2
-
non-proton-pumping NADH-ubiquinone oxidoreductase
NDH-2
-
non-proton-pumping NADH-ubiquinone oxidoreductase
NDH-2A
-
NDH2
-
-
Ndi1p
-
-
NrcN
-
PAI
-
-
PAI
Vitis vinifera x Vitis vinifera
-
-
proton-pumping NADH-ubiquinone oxidoreductase
-
-
proton-pumping NADH-ubiquinone oxidoreductase
-
-
-
proton-pumping NADH-ubiquinone oxidoreductase
-
-
proton-pumping NADH:ubiquinone oxidoreductase
-
-
proton-pumping NADH:ubiquinone oxidoreductase
-
-
RCC-I
-
-
respiratory chain complex I
-
-
respiratory chain complex I
-
-
respiratory chain complex I
-
-
respiratory complex I
-
-
respiratory complex I
-
-
respiratory complex I
-
-
-
respiratory complex I
-
-
respiratory complex I
-
-
respiratory complex I
-
-
TT_C1484
-
type I NADH dehydrogenase
-
-
type I NADH dehydrogenase
-
-
-
type I NADH dehydrogenase
-
-
type II NADH dehydrogenase
-
-
type II NADH dehydrogenase
-
-
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2 ferricyanide + deamino-NADH
2 ferrocyanide + deamino-NAD+ + H+
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
2 ferricyanide + NADPH
2 ferrocyanide + NADP+ + H+
2 ferricytochrome c + NADH
2 ferrocytochrome c + NAD+ + H+
2,3-dimethyl-1,4-naphthoquinone + NADH + H+
2,3-dimethyl-1,4-hydronaphthoquinol + NAD+
-
-
-
-
?
2-methyl-1,4-naphthoquinone + NADH + H+
2-methyl-1,4-naphthoquinol + NAD+
amplex red + NADH + O2
resorufin + NAD+ + H2O2
-
the rate of H2O2 formation by complex I strongly depends upon the NAD+/NADH ratio
-
-
?
benzoquinone + NADH + H+
benzohydroquinone + NAD+
-
-
-
-
?
deamino-NADH + dimethoxy-5-methyl-6-decyl-1,4-benzoquinone
deamino-NAD+ + reduced dimethoxy-5-methyl-6-decyl-1,4-benzoquinone
-
-
-
-
?
deamino-NADH + ubiquinone
deamino-NAD+ + ubiquinol
-
-
-
-
?
deamino-NADH + ubiquinone + H+[side 1]
deamino-NAD+ + ubiquinol + H+[side 2]
-
-
-
-
?
deamino-nicotinamide-adeninedinucleotide + n-decylubiquinone
? + n-decylubiquinol
-
-
-
-
?
decyl-ubiquinone + NADH
decyl-ubiquinol + NAD+
-
-
-
-
?
decyl-ubiquinone + NADH + H+
decyl-ubiquinol + NAD+
-
-
-
-
?
dihydroethidium + O2
ethidium + H2O2
-
dihydroethidium reduction shows that, upon reducing O2, it produces approximately 20% superoxide and 80% H2O2
-
-
?
malate + pyruvate + O2
?
-
-
-
-
?
NADH + 1,1'-carbamoylmethylviologen
NAD+ + reduced 1,1'-carbamoylmethylviologen
-
-
-
-
r
NADH + 2,3-dimethoxy-5-methyl-6-isoprenyl-1,4-benzoquinone
NAD+ + ?
-
-
-
-
?
NADH + 2,3-dimethoxy-5-methyl-6-[(6-methyl-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-yl)methyl]benzo-1,4-quinone
NAD+ + ?
NADH + 2,3-dimethoxy-5-methyl-6-[(6-methylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]benzo-1,4-quinone
NAD+ + 2,3-dimethoxy-5-methyl-6-[(6-methylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]benzene-1,4-diol
-
-
-
-
?
NADH + 2,3-dimethoxy-5-methyl-6-[(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]benzo-1,4-quinone
NAD+ + 2,3-dimethoxy-5-methyl-6-[(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]benzene-1,4-diol
-
-
-
-
?
NADH + 2-methyl-1,4-naphthoquinone
NAD+ + 2-methyl-1,4-naphthoquinol
-
-
-
-
?
NADH + 2-methylnaphthoquinone
NAD+ + 2-methylnaphthalene-1,4-diol
NADH + 2-[(2,6-dimethylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzo-1,4-quinone
NAD+ + 2-[(2,6-dimethylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzene-1,4-diol
-
-
-
-
?
NADH + 2-[(2-chloro-6-methylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzo-1,4-quinone
NAD+ + 2-[(2-chloro-6-methylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzene-1,4-diol
-
-
-
-
?
NADH + 2-[(2-chloro-6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzo-1,4-quinone
NAD+ + 2-[(2-chloro-6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzene-1,4-diol
-
-
-
-
?
NADH + 2-[(6-chloro-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzo-1,4-quinone
NAD+ + 2-[(6-chloro-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzene-1,4-diol
-
-
-
-
?
NADH + 2-[(6-chloro-2-methylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzo-1,4-quinone
NAD+ + 2-[(6-chloro-2-methylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzene-1,4-diol
-
-
-
-
?
NADH + 2-[(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzo-1,4-quinone
NAD+ + 2-[(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzene-1,4-diol
-
-
-
-
?
NADH + 3'-acetyl pyridine adenine dinucleotide
NAD+ + ?
-
-
-
-
?
NADH + 6-decyl-ubiquinone
NAD+ + 6-decyl-ubiquinol
-
-
-
-
?
NADH + anthraquinone-2,6-disulfonate
NAD+ + ?
-
-
-
-
?
NADH + benzoquinone
NAD+ + benzoquinol
-
-
-
-
?
NADH + benzoquinone + H+
NAD+ + benzoquinol
-
-
-
-
?
NADH + caldariellaquinone
NAD+ + caldariellaquinol
NADH + coenzyme Q0
NAD+ + ?
-
-
-
-
?
NADH + coenzyme Q1
NAD+ + ?
-
-
-
-
?
NADH + coenzyme Q1 + H+
NAD+ + reduced coenzyme Q1
-
-
-
-
?
NADH + coenzyme Q2
NAD+ + ?
-
-
-
-
?
NADH + decyl-ubiquinone
NAD+ + decyl-ubiquinol
-
-
-
-
?
NADH + decyl-ubiquinone + H+
NAD+ + decyl-ubiquinol
-
-
-
-
?
NADH + decylubiquinone
NAD+ + decylubiquinol
NADH + decylubiquinone + H+
NAD+ + decylubiquinol
-
-
-
-
?
NADH + duroquinone
NAD+ + ?
-
-
-
-
?
NADH + duroquinone
NAD+ + duroquinol
NADH + FAD
NAD+ + FADH2
-
-
-
-
?
NADH + Fe(CN)63-
?
-
-
-
-
?
NADH + ferricyanide
NAD+ + H+ + ferrocyanide
-
-
-
-
?
NADH + ferricytochrome c
NAD+ + H+ + ferrocytochrome c
NADH + H+ + 1,4-benzoquinone
NAD+ + 1,4-benzoquinol
-
-
-
-
?
NADH + H+ + 1,4-naphthoquinone
NAD+ + 1,4-naphthoquinol
NADH + H+ + 2,5-dimethyl-1,4-benzoquinone
NAD+ + 2,5-dimethyl-1,4-benzoquinol
-
-
-
-
?
NADH + H+ + 2-methyl-1,4-benzoquinone
NAD+ + 2-methyl-1,4-benzoquinol
-
-
-
-
?
NADH + H+ + 2-methyl-1,4-naphthoquinone
NAD+ + 2-methyl-1,4-naphthoquinol
-
-
-
-
?
NADH + H+ + 4-nitroacetophenone
NAD+ + ?
-
-
-
-
?
NADH + H+ + 4-nitrobenzaldehyde
NAD+ + ?
-
-
-
-
?
NADH + H+ + 4-nitrobenzoic acid
NAD+ + ?
-
-
-
-
?
NADH + H+ + 5,8-dioxo-1,4-naphthoquinone
NAD+ + 5,8-dioxo-1,4-naphthoquinol
-
-
-
-
?
NADH + H+ + 5-oxo-1,4-naphthoquinone
NAD+ + 5-oxo-1,4-naphthoquinol
-
-
-
-
?
NADH + H+ + 9,10-phenanthrenequinone
NAD+ + 9,10-phenanthrenequinol
-
-
-
-
?
NADH + H+ + adriamycin
NAD+ + ?
-
-
-
-
?
NADH + H+ + coenzyme Q1
NAD+ + reduced coenzyme Q1
NADH + H+ + coenzyme Q2
NAD+ + reduced coenzyme Q2
-
-
-
-
?
NADH + H+ + decylubiquinone
NAD+ + decylubiquinol
NADH + H+ + duroquinone
NAD+ + duroquinol
NADH + H+ + idebenone
NAD+ + ?
-
studies of ubiquinone reduction by isolated complex I are problematic because the extremely hydrophobic natural substrate, ubiquinone-10, must be substituted with a relatively hydrophilic analogue (such as ubiquinone-1). Hydrophilic ubiquinones are reduced by an additional, non-energy-transducing pathway. Inhibitor-insensitive ubiquinone reduction occurs by a ping-pong type mechanism, catalyzed by the flavin mononucleotide cofactor in the active site for NADH oxidation. Moreover, semiquinones produced at the flavin site initiate redox cycling reactions with molecular oxygen, producing superoxide radicals and hydrogen peroxide. The ubiquinone reactant is regenerated, so the NADH:Q reaction becomes superstoichiometric. Idebenone, an artificial ubiquinone, reacts at the flavin site
-
-
?
NADH + H+ + menadione
NAD+ + menadiol
NADH + H+ + menaquinone
NAD+ + menaquinol
NADH + H+ + nifuroxime
NAD+ + ?
-
-
-
-
?
NADH + H+ + nitrobenzene
NAD+ + ?
-
-
-
-
?
NADH + H+ + nitrofurantoin
NAD+ + ?
-
-
-
-
?
NADH + H+ + oxidized dichlorophenolindophenol
NAD+ + reduced dichlorophenolindophenol
-
-
-
-
?
NADH + H+ + tetramethyl-1,4-benzoquinone
NAD+ + tetramethyl-1,4-benzoquinol
-
-
-
-
?
NADH + H+ + ubiquinone
NAD+ + ubiquinol
NADH + H+ + ubiquinone-0
NAD+ + ubiquinol-0
NADH + H+ + ubiquinone-1
NAD+ + ubiquinol-1
NADH + H+ + ubiquinone-10
NAD+ + ubiquinol-10
NADH + H+ + ubiquinone-2
NAD+ + ubiquinol-2
-
-
-
-
?
NADH + H+ + vitamin K2
NAD+ + reduced vitamin K2
NADH + hexaamineruthenium(III) chloride
NAD+ + ?
-
-
-
-
?
NADH + hexaammineruthenium-(III)-chloride
NAD+ + ?
-
-
-
-
?
NADH + hexaammineruthenium-III-chloride
NAD+ + ?
NADH + hexamineruthenium(III)-chloride
NAD+ + ?
-
-
-
-
?
NADH + hexammineruthenium-(III)-chloride
NAD+ + ?
NADH + menadione
NAD+ + menadiol
NADH + menadione
NAD+ + reduced menadione
-
-
-
-
?
NADH + menaquinone
NAD+ + menaquinol
-
-
-
-
?
NADH + menaquinone + H+
NAD+ + menaquinol
-
-
-
-
?
NADH + n-decylubiquinone + 5 H+[side1]
NAD+ + n-decylubiquinol + 4 H+[side2]
NADH + n-decylubiquinone + H+
NAD+ + n-decylubiquinol
NADH + naphthoquinone
NAD+ + naphthoquinol
-
-
-
-
?
NADH + nitroblue tetrazolium
NAD+ + reduced nitroblue tetrazolium
-
-
-
-
?
NADH + O2
NAD+ + superoxide radical
NADH + oxidized 2,6-dichlorophenolindophenol
NAD+ + reduced 2,6-dichlorophenolindophenol
NADH + oxidized 2,6-dichlorophenolindophenol + H+
NAD+ + reduced 2,6-dichlorophenolindophenol
NADH + oxidized coenzyme Q1 + 5 H+[side1]
NAD+ + reduced coenzyme Q1 + 4 H+[side2]
-
-
-
?
NADH + phylloquinone
NAD+ + phylloquinol
-
-
-
-
?
NADH + plastoquinone
NAD+ + plastoquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
NADH + ubiquinone + 6 H+[side 1]
NAD+ + ubiquinol + 7 H+[side 2]
NADH + ubiquinone + H+
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone-0
NAD+ + ubiquinol-0
NADH + ubiquinone-1
NAD+ + reduced ubiquinone-1
-
-
-
-
?
NADH + ubiquinone-1
NAD+ + ubiquinol-1
NADH + ubiquinone-1 + 5 H+[side 1]
NAD+ + ubiquinol-1 + 4 H+[side 2]
NADH + ubiquinone-1 + H+
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone-10
NAD+ + ubiquinol-10
NADH + ubiquinone-10 + 5 H+[side 1]
NAD+ + ubiquinol-10 + 4 H+[side 2]
-
-
-
-
?
NADH + ubiquinone-2
NAD+ + reduced ubiquinol-2
NADH + ubiquinone-2
NAD+ + ubiquinol-2
NADH + ubiquinone-6
NAD+ + ubiquinol-6
NADH + ubiquinone-8
NAD+ + ubiquinol-8
NADH + ubiquinone-9
NAD+ + ubiquinol-9
-
-
-
-
?
NADPH + 2-methylnaphthoquinone
NADP+ + ?
-
about 1% of the activity with NADH
-
-
?
NADPH + H+ + ubiquinone
NADP+ + ubiquinol
NADPH + H+ + ubiquinone-1
NADP+ + ubiquinol-1
-
at a slow rate
-
-
?
NADPH + ubiquinone + 6 H+[side 1]
NADP+ + ubiquinol + 7 H+[side 2]
-
NADPH is a poor substrate of the complex
-
-
?
oxidized 2,6-dichlorophenolindophenol + NADH + H+
reduced 2,6-dichlorophenolindophenol + NAD+
-
-
-
-
?
succinate + O2 + NAD+
NADH + ?
-
-
-
-
?
ubiquinone + NADH + H+
ubiquinol + NAD+
-
-
-
-
?
ubiquinone-1 + NADH + H+
ubiquinol-1 + NAD+
additional information
?
-
2 ferricyanide + deamino-NADH
2 ferrocyanide + deamino-NAD+ + H+
-
-
-
-
?
2 ferricyanide + deamino-NADH
2 ferrocyanide + deamino-NAD+ + H+
-
-
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
-
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
-
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
-
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
232.7% of the activity with ubiquinone-1
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
-
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
-
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
activity is 27.4fold of the activity with ubiquinone-1
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
-
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
-
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
-
-
-
?
2 ferricyanide + NADPH
2 ferrocyanide + NADP+ + H+
-
0.13% of the activity with NADH and ferricyanide
-
-
?
2 ferricyanide + NADPH
2 ferrocyanide + NADP+ + H+
-
about 1% of the activity with NADH
-
-
?
2 ferricytochrome c + NADH
2 ferrocytochrome c + NAD+ + H+
-
8.3% of the activity with ubiquinone-1
-
-
?
2 ferricytochrome c + NADH
2 ferrocytochrome c + NAD+ + H+
-
-
-
-
?
2 ferricytochrome c + NADH
2 ferrocytochrome c + NAD+ + H+
-
12%-16% of the activity with ubiquinone-1
-
-
?
2 ferricytochrome c + NADH
2 ferrocytochrome c + NAD+ + H+
-
-
-
-
?
2 ferricytochrome c + NADH
2 ferrocytochrome c + NAD+ + H+
-
-
-
-
?
2 ferricytochrome c + NADH
2 ferrocytochrome c + NAD+ + H+
-
-
-
-
?
2-methyl-1,4-naphthoquinone + NADH + H+
2-methyl-1,4-naphthoquinol + NAD+
-
specific for NADH
-
-
?
2-methyl-1,4-naphthoquinone + NADH + H+
2-methyl-1,4-naphthoquinol + NAD+
-
i.e. menadione
-
-
?
NADH + 2,3-dimethoxy-5-methyl-6-[(6-methyl-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-yl)methyl]benzo-1,4-quinone
NAD+ + ?
-
-
-
-
?
NADH + 2,3-dimethoxy-5-methyl-6-[(6-methyl-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-yl)methyl]benzo-1,4-quinone
NAD+ + ?
-
-
-
-
?
NADH + 2-methylnaphthoquinone
NAD+ + 2-methylnaphthalene-1,4-diol
-
-
-
-
?
NADH + 2-methylnaphthoquinone
NAD+ + 2-methylnaphthalene-1,4-diol
-
7.6% of the activity with ubiquinone-1
-
-
?
NADH + caldariellaquinone
NAD+ + caldariellaquinol
-
-
-
-
?
NADH + caldariellaquinone
NAD+ + caldariellaquinol
-
-
-
-
?
NADH + caldariellaquinone
NAD+ + caldariellaquinol
-
-
-
-
?
NADH + coenzyme Q10
?
-
-
-
-
?
NADH + coenzyme Q10
?
-
-
-
-
?
NADH + decylubiquinone
NAD+ + decylubiquinol
-
-
-
-
?
NADH + decylubiquinone
NAD+ + decylubiquinol
-
no activity with the enzymatically active subcomplexes Ilambda, IS, and IlamdaS at similar rates to complex I
-
-
?
NADH + decylubiquinone
NAD+ + decylubiquinol
-
ordered sequential mechanism in which the order of substrate bindings and product release is: NADH, decylubiquinone, decylubiquinol, NAD+
-
-
?
NADH + decylubiquinone
NAD+ + decylubiquinol
-
-
-
-
?
NADH + decylubiquinone
NAD+ + decylubiquinol
-
-
-
-
?
NADH + decylubiquinone
NAD+ + decylubiquinol
-
-
-
-
?
NADH + decylubiquinone
NAD+ + decylubiquinol
-
-
-
-
?
NADH + decylubiquinone
NAD+ + decylubiquinol
-
-
-
-
?
NADH + decylubiquinone
NAD+ + decylubiquinol
-
-
-
-
?
NADH + decylubiquinone
NAD+ + decylubiquinol
-
n-decylubiquinone
-
-
?
NADH + duroquinone
NAD+ + duroquinol
-
-
-
-
?
NADH + duroquinone
NAD+ + duroquinol
-
64.5% of the activity with ubiquinone-1
-
-
?
NADH + duroquinone
NAD+ + duroquinol
-
-
-
?
NADH + ferricytochrome c
NAD+ + H+ + ferrocytochrome c
-
-
-
-
?
NADH + ferricytochrome c
NAD+ + H+ + ferrocytochrome c
-
-
-
-
?
NADH + H+ + 1,4-naphthoquinone
NAD+ + 1,4-naphthoquinol
-
-
-
-
?
NADH + H+ + 1,4-naphthoquinone
NAD+ + 1,4-naphthoquinol
-
-
-
-
?
NADH + H+ + coenzyme Q1
NAD+ + reduced coenzyme Q1
-
-
-
-
?
NADH + H+ + coenzyme Q1
NAD+ + reduced coenzyme Q1
-
ordered sequential mechanism in which the order of substrate binding and product release is coenzyme Q1, NADH, NAD+ and reduced coenzyme coenzyme Q1
-
-
?
NADH + H+ + coenzyme Q1
NAD+ + reduced coenzyme Q1
-
-
-
-
?
NADH + H+ + coenzyme Q1
NAD+ + reduced coenzyme Q1
-
-
-
-
?
NADH + H+ + decylubiquinone
NAD+ + decylubiquinol
-
-
-
-
?
NADH + H+ + decylubiquinone
NAD+ + decylubiquinol
-
decylubiquinone is slightly better than ubiquinone-1 as electron acceptor
-
-
?
NADH + H+ + decylubiquinone
NAD+ + decylubiquinol
-
-
-
-
?
NADH + H+ + decylubiquinone
NAD+ + decylubiquinol
-
the enzyme is selective for NADH
-
-
?
NADH + H+ + decylubiquinone
NAD+ + decylubiquinol
-
-
-
?
NADH + H+ + decylubiquinone
NAD+ + decylubiquinol
-
-
-
?
NADH + H+ + duroquinone
NAD+ + duroquinol
-
-
-
?
NADH + H+ + duroquinone
NAD+ + duroquinol
-
-
-
?
NADH + H+ + menadione
NAD+ + menadiol
-
-
-
-
?
NADH + H+ + menadione
NAD+ + menadiol
-
-
-
?
NADH + H+ + menadione
NAD+ + menadiol
-
-
-
?
NADH + H+ + menaquinone
NAD+ + menaquinol
-
-
-
-
?
NADH + H+ + menaquinone
NAD+ + menaquinol
-
the enzyme plays an essential role in maintaining a reduced ubiquinone-pool during infection (Mycobacterium tuberculosis is the causative agents of tuberculosis). The enzyme is not only essential to parasite survival in vivo but may also contribute to the severity and outcome of disease. Type II NADH:quinone oxidoreductase the membrane-bound respiratory enzyme differs from the canonical NADH:dehydrogenase (complex I), because it is not involved in the vectorial transfer of protons across membranes. Mycobacterium tuberculosis contains a branched respiratory chain terminating in a cytochrome bd (quinol) oxidase and an aa3-type cytochrome c oxidase. Both chains are fed by a menaquinol (MQH2) pool that is generated by four dehydrogenases; one succinate menaquinone oxidoreductase (SQR), one multimeric type I NADH: dehydrogenase (complex I), and two type II NADH: menaquinone oxidoreductases (ndh and ndhA). Transposon insertion knockout strategy reveals that disruption of the ndh gene is lethal
-
-
?
NADH + H+ + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + H+ + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + H+ + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + H+ + ubiquinone
NAD+ + ubiquinol
-
conserved lysine residues of the membrane subunit NuoM are involved in energy conversion by the proton-pumping NADH:ubiquinone oxidoreductase
-
-
?
NADH + H+ + ubiquinone
NAD+ + ubiquinol
-
the energy-converting NADH:ubiquinone oxidoreductase (respiratory complex I), couples the transfer of electrons from NADH to ubiquinone with the translocation of protons across the membrane
-
-
?
NADH + H+ + ubiquinone
NAD+ + ubiquinol
-
NADH:ubiquinone oxidoreductase or complex I is a large multisubunit assembly of the mitochondrial inner membrane that channels high-energy electrons from metabolic NADH into the electron transport chain. Its dysfunction is associated with a range of progressive neurological disorders, often characterized by a very early onset and short devastating course. Reduction in cellular complex I activity leads to a depolarization of the mitochondrial membrane potential, resulting in a decreased supply of mitochondrial ATP to the Ca2+-ATPases of the intracellular stores and thus to a reduced Ca2+ content of these stores
-
-
?
NADH + H+ + ubiquinone-0
NAD+ + ubiquinol-0
-
-
-
-
?
NADH + H+ + ubiquinone-0
NAD+ + ubiquinol-0
-
-
-
-
?
NADH + H+ + ubiquinone-0
NAD+ + ubiquinol-0
-
prefers ubiquinol-0 as an acceptor substrate, and can also use the artificial electron acceptors, menadione and dichlorophenolindophenol
-
-
?
NADH + H+ + ubiquinone-1
NAD+ + ubiquinol-1
-
-
-
-
?
NADH + H+ + ubiquinone-1
NAD+ + ubiquinol-1
-
-
-
?
NADH + H+ + ubiquinone-1
NAD+ + ubiquinol-1
-
formation of the semiquinone signals during steady state electron transfer from NADH to ubiquinone-1
-
-
?
NADH + H+ + ubiquinone-1
NAD+ + ubiquinol-1
-
studies of ubiquinone reduction by isolated complex I are problematic because the extremely hydrophobic natural substrate, ubiquinone-10, must be substituted with a relatively hydrophilic analogue (such as ubiquinone-1). Hydrophilic ubiquinones are reduced by an additional, non-energy-transducing pathway. Inhibitor-insensitive ubiquinone reduction occurs by a ping-pong type mechanism, catalyzed by the flavin mononucleotide cofactor in the active site for NADH oxidation. Moreover, semiquinones produced at the flavin site initiate redox cycling reactions with molecular oxygen, producing superoxide radicals and hydrogen peroxide. The ubiquinone reactant is regenerated, so the NADH:Q reaction becomes superstoichiometric. Idebenone, an artificial ubiquinone, reacts at the flavin site
-
-
?
NADH + H+ + ubiquinone-1
NAD+ + ubiquinol-1
-
-
-
-
?
NADH + H+ + ubiquinone-1
NAD+ + ubiquinol-1
-
-
-
-
?
NADH + H+ + ubiquinone-1
NAD+ + ubiquinol-1
-
-
-
-
?
NADH + H+ + ubiquinone-1
NAD+ + ubiquinol-1
-
-
-
?
NADH + H+ + ubiquinone-1
NAD+ + ubiquinol-1
-
-
-
?
NADH + H+ + ubiquinone-10
NAD+ + ubiquinol-10
-
the natural substrate ubiquinone-10 is extremely hydrophobic
-
-
?
NADH + H+ + ubiquinone-10
NAD+ + ubiquinol-10
-
studies of ubiquinone reduction by isolated complex I are problematic because the extremely hydrophobic natural substrate, ubiquinone-10, must be substituted with a relatively hydrophilic analogue (such as ubiquinone-1). Hydrophilic ubiquinones are reduced by an additional, non-energy-transducing pathway. Inhibitor-insensitive ubiquinone reduction occurs by a ping-pong type mechanism, catalyzed by the flavin mononucleotide cofactor in the active site for NADH oxidation. Moreover, semiquinones produced at the flavin site initiate redox cycling reactions with molecular oxygen, producing superoxide radicals and hydrogen peroxide. The ubiquinone reactant is regenerated, so the NADH:Q reaction becomes superstoichiometric. Idebenone, an artificial ubiquinone, reacts at the flavin site
-
-
?
NADH + H+ + vitamin K2
NAD+ + reduced vitamin K2
-
-
-
?
NADH + H+ + vitamin K2
NAD+ + reduced vitamin K2
-
-
-
?
NADH + hexaammineruthenium-III-chloride
NAD+ + ?
-
-
-
-
?
NADH + hexaammineruthenium-III-chloride
NAD+ + ?
-
-
-
-
?
NADH + hexammineruthenium-(III)-chloride
NAD+ + ?
-
-
-
-
?
NADH + hexammineruthenium-(III)-chloride
NAD+ + ?
-
-
-
-
?
NADH + hexammineruthenium-(III)-chloride
NAD+ + ?
-
-
-
-
?
NADH + menadione
NAD+ + menadiol
-
menadione is a poor electron acceptor
-
?
NADH + menadione
NAD+ + menadiol
-
-
-
-
?
NADH + n-decylubiquinone + 5 H+[side1]
NAD+ + n-decylubiquinol + 4 H+[side2]
-
-
-
?
NADH + n-decylubiquinone + 5 H+[side1]
NAD+ + n-decylubiquinol + 4 H+[side2]
-
-
-
?
NADH + n-decylubiquinone + H+
NAD+ + n-decylubiquinol
-
-
-
-
?
NADH + n-decylubiquinone + H+
NAD+ + n-decylubiquinol
-
-
-
-
?
NADH + O2
NAD+ + superoxide radical
-
addition of NADH, but not decylubiquinol, leads to superoxide production
-
-
?
NADH + O2
NAD+ + superoxide radical
-
-
-
?
NADH + O2
NAD+ + superoxide radical
-
-
-
-
?
NADH + oxidized 2,6-dichlorophenolindophenol
NAD+ + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
NADH + oxidized 2,6-dichlorophenolindophenol
NAD+ + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
NADH + oxidized 2,6-dichlorophenolindophenol
NAD+ + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
NADH + oxidized 2,6-dichlorophenolindophenol + H+
NAD+ + reduced 2,6-dichlorophenolindophenol
-
41.7% of the activity with ubiquinone-1
-
-
?
NADH + oxidized 2,6-dichlorophenolindophenol + H+
NAD+ + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
NADH + oxidized 2,6-dichlorophenolindophenol + H+
NAD+ + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
NADH + oxidized 2,6-dichlorophenolindophenol + H+
NAD+ + reduced 2,6-dichlorophenolindophenol
-
2,6-dichlorophenolindophenol is a poor electron acceptor
-
?
NADH + oxidized 2,6-dichlorophenolindophenol + H+
NAD+ + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
NADH + oxidized 2,6-dichlorophenolindophenol + H+
NAD+ + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
NADH + oxidized 2,6-dichlorophenolindophenol + H+
NAD+ + reduced 2,6-dichlorophenolindophenol
-
2,6-dichlorophenol indophenol as electron acceptor
-
-
?
NADH + oxidized 2,6-dichlorophenolindophenol + H+
NAD+ + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
NADH + oxidized 2,6-dichlorophenolindophenol + H+
NAD+ + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
NADH + ubiquinone
?
-
enzyme is involved in respiratory chain
-
-
?
NADH + ubiquinone
?
-
NADH-ubiquinone reductase complex I is involved in the respiratory chain
-
-
?
NADH + ubiquinone
?
-
proton-translocating enzyme
-
-
?
NADH + ubiquinone
?
-
vectorial electron translocation is coupled to electron transfer
-
-
?
NADH + ubiquinone
?
-
-
-
-
?
NADH + ubiquinone
?
-
mutations in NADH:ubiquinone oxidoreductase NADH of Escherichia coli affect growth on mixed amino acids, because the large NADH/NAD+ ratio inhibits enzymes, e.g. citrate synthase and malate dehydrogenase, shared by the tricarboxylic acid cycle and the glyoxylate shunt
-
-
?
NADH + ubiquinone
?
-
-
-
-
?
NADH + ubiquinone
?
-
proton-translocating enzyme
-
-
?
NADH + ubiquinone
?
-
the enzyme catalyzes the transfer of electrons without translocation of protons across the membrane
-
-
?
NADH + ubiquinone
?
-
proton-translocating enzyme
-
-
?
NADH + ubiquinone
?
-
proton-translocating NADH-ubiquinone oxidoreductase is the largest multiprotein complex of the respiratory chain
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
391082, 392676, 392677, 392684, 392691, 392699, 392703, 392717, 392718, 392721, 671827, 671993, 672129, 672176, 672291, 672348, 672597, 675345, 676868 -
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
proton-translocating enzyme
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
392678, 392681, 392682, 392692, 392718, 671940, 672008, 672041, 673620, 673940, 674624, 675494 -
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
proton-translocating enzyme
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
proton-translocating enzyme
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone
NAD+ + ubiquinol
-
-
-
-
?
NADH + ubiquinone + 6 H+[side 1]
NAD+ + ubiquinol + 7 H+[side 2]
-
-
-
-
?
NADH + ubiquinone + 6 H+[side 1]
NAD+ + ubiquinol + 7 H+[side 2]
-
-
-
-
?
NADH + ubiquinone + 6 H+[side 1]
NAD+ + ubiquinol + 7 H+[side 2]
-
-
-
-
?
NADH + ubiquinone + 6 H+[side 1]
NAD+ + ubiquinol + 7 H+[side 2]
-
-
-
-
?
NADH + ubiquinone + 6 H+[side 1]
NAD+ + ubiquinol + 7 H+[side 2]
-
-
-
-
?
NADH + ubiquinone + 6 H+[side 1]
NAD+ + ubiquinol + 7 H+[side 2]
-
-
-
-
?
NADH + ubiquinone + 6 H+[side 1]
NAD+ + ubiquinol + 7 H+[side 2]
-
electron transfer path from FMN to ubiquinone through the FeS cluster chain. Upon the oxidation of one NADH molecule 4H+ are translocated across the membrane from N-side (cytoplasm, equivalent to the mitochondrial matrix) to P-side (periplasm, equivalent to the mitochondrial intermembrane space)
-
-
?
NADH + ubiquinone + 6 H+[side 1]
NAD+ + ubiquinol + 7 H+[side 2]
-
-
-
-
?
NADH + ubiquinone-0
NAD+ + ubiquinol-0
-
-
-
-
?
NADH + ubiquinone-0
NAD+ + ubiquinol-0
-
-
-
-
?
NADH + ubiquinone-0
NAD+ + ubiquinol-0
-
-
-
-
?
NADH + ubiquinone-1
NAD+ + ubiquinol-1
-
-
-
-
?
NADH + ubiquinone-1
NAD+ + ubiquinol-1
-
-
-
-
?
NADH + ubiquinone-1
NAD+ + ubiquinol-1
-
-
-
-
?
NADH + ubiquinone-1
NAD+ + ubiquinol-1
-
reaction is catalyzed by the enzymatically active subcomplexes Ilambda, IS, and IlamdaS at similar rates to complex I
-
-
?
NADH + ubiquinone-1
NAD+ + ubiquinol-1
-
-
-
-
?
NADH + ubiquinone-1
NAD+ + ubiquinol-1
-
-
-
?
NADH + ubiquinone-1
NAD+ + ubiquinol-1
-
-
-
-
?
NADH + ubiquinone-1
NAD+ + ubiquinol-1
-
-
-
?
NADH + ubiquinone-1
NAD+ + ubiquinol-1
-
-
-
-
?
NADH + ubiquinone-1
NAD+ + ubiquinol-1
-
-
-
-
?
NADH + ubiquinone-1
NAD+ + ubiquinol-1
-
-
-
-
?
NADH + ubiquinone-1
NAD+ + ubiquinol-1
-
-
-
-
?
NADH + ubiquinone-1
NAD+ + ubiquinol-1
-
-
-
-
?
NADH + ubiquinone-1
NAD+ + ubiquinol-1
-
-
-
-
?
NADH + ubiquinone-1 + 5 H+[side 1]
NAD+ + ubiquinol-1 + 4 H+[side 2]
-
-
-
-
?
NADH + ubiquinone-1 + 5 H+[side 1]
NAD+ + ubiquinol-1 + 4 H+[side 2]
-
-
-
-
?
NADH + ubiquinone-1 + 5 H+[side 1]
NAD+ + ubiquinol-1 + 4 H+[side 2]
-
-
-
?
NADH + ubiquinone-10
NAD+ + ubiquinol-10
-
-
-
-
?
NADH + ubiquinone-10
NAD+ + ubiquinol-10
-
-
-
-
?
NADH + ubiquinone-2
NAD+ + reduced ubiquinol-2
-
-
-
-
?
NADH + ubiquinone-2
NAD+ + reduced ubiquinol-2
-
-
-
-
?
NADH + ubiquinone-2
NAD+ + reduced ubiquinol-2
-
-
-
-
?
NADH + ubiquinone-2
NAD+ + reduced ubiquinol-2
-
-
-
-
?
NADH + ubiquinone-2
NAD+ + reduced ubiquinol-2
-
-
-
-
?
NADH + ubiquinone-2
NAD+ + ubiquinol-2
-
-
-
-
?
NADH + ubiquinone-2
NAD+ + ubiquinol-2
-
-
-
-
?
NADH + ubiquinone-2
NAD+ + ubiquinol-2
-
-
-
-
?
NADH + ubiquinone-2
NAD+ + ubiquinol-2
-
-
-
-
?
NADH + ubiquinone-2
NAD+ + ubiquinol-2
-
-
-
-
?
NADH + ubiquinone-6
NAD+ + ubiquinol-6
-
86% of the activity with ubiquinone-1
-
-
?
NADH + ubiquinone-6
NAD+ + ubiquinol-6
-
-
-
-
?
NADH + ubiquinone-8
NAD+ + ubiquinol-8
-
-
-
-
?
NADH + ubiquinone-8
NAD+ + ubiquinol-8
-
-
-
-
?
NADPH + H+ + ubiquinone
NADP+ + ubiquinol
-
the enzyme has a lower affinity to NADPH than to NADH
-
-
?
NADPH + H+ + ubiquinone
NADP+ + ubiquinol
-
-
-
-
?
ubiquinone-1 + NADH + H+
ubiquinol-1 + NAD+
-
the protein shows NADH-ubiquinone-1 oxidoreductase activity, NADPH oxidase (EC 1.6.3.1) and NADPH-ubiquinone-1 oxidoreductase (EC 1.6.5.2) activities
-
-
?
ubiquinone-1 + NADH + H+
ubiquinol-1 + NAD+
-
-
-
-
?
additional information
?
-
-
no transhydrogenase activity with NADPH
-
-
?
additional information
?
-
-
NADH-NADP transhydrogenation at a very slow rate
-
-
?
additional information
?
-
-
complex I also shows NADH oxidase activity
-
-
?
additional information
?
-
-
no redox-coupled Na+ transport, but the deactive form of complex I, which is formed spontaneously when enzyme turnover is precluded by lack of substrates, is a Na+/H+ antiporter. The antiporter activity is Na+-specific and is abolished upon reactivation by the addition of substrates and by the complex I inhibitor rotenone. It is specific for Na+ over K+
-
-
?
additional information
?
-
-
the enzyme shows also rotenone-insensitive NADH:hexaammineruthenium III (HAR) oxidoreductase activity
-
-
?
additional information
?
-
-
the positively-charged electron acceptors paraquat and hexaammineruthenium(III) react with the nucleotide-bound reduced flavin in complex I, by an unusual ternary mechanism, overview. The mechanism for paraquat reduction defines another mechanism for superoxide production by complex I by redox cycling
-
-
?
additional information
?
-
-
no activity with coenzyme Q10
-
-
?
additional information
?
-
-
complex I is a primary electrogenic proton pump and may be capable of secondary sodium antiport. The magnitude of the pH-gradient depends on the sodium concentration
-
-
?
additional information
?
-
-
FMN-dependent NADH-quinone reductase induced by menadione
-
-
?
additional information
?
-
-
midpoint potentials for the redox transitions of the quinone radicals in complex I are -37 and -235 mV at pH 6 with an absorption around 325 nm and a fluorescence emission at 460/475 nm
-
-
?
additional information
?
-
-
NADH:ubiquinone oxidoreductase (EC 1.6.5.3) constitutes the entry point of electrons in the electron transport chain. Mitochondrial NADH:ubiquinone oxidoreductase or complex I (CI) is a frequently affected enzyme in cases of mitochondrial disorders
-
-
?
additional information
?
-
-
computational model of mammalian complex I for catalysis. The fully reduced FMN and semiquinone are the primary sources of superoxide, and the iron-sulfur cluster N2 produces none. The FMN radical only produces reactive oxygen species when the quinone reductase site is blocked. Reaxtive oxygen species generation is maximized during reverse electron transport with both the FMN and semiquinone producing similar amounts of superoxide. The model successfully predicts the increase in reactive oxygen species generation when the membrane potential is high and matrix pH is alkaline
-
-
?
additional information
?
-
-
the enzyme mediates electron transfer to particulate methane monooxygenase
-
-
?
additional information
?
-
-
does not react with NADPH or oxygen
-
-
?
additional information
?
-
-
enzyme catalyzes the transfer electrons from NADH to quinone substrates by a nonclassical, two-site pingpong kinetic mechanism whereby substrate quinones bind to a site that is distinct from the NADH-binding site. Presence of two binding sites for quinone ligands, one favoring the reduced form and the other favoring the oxidized form
-
-
?
additional information
?
-
-
the enzyme shows also rotenone-insensitive NADH:hexaammineruthenium III (HAR) oxidoreductase activity. The enzyme NDH-1 catalyzes a number of the NADH:artificial electron acceptor oxidoreductase activities showing particularly high turnover numbers with ferricyanide and hexaammineruthenium(III), kinetic patterns of the steady-state NADH oxidation with these two electron acceptors, overview
-
-
?
additional information
?
-
-
no activity with coenzyme Q4 and coenzyme QD
-
-
?
additional information
?
-
-
superoxide production from complex I is large under conditions of reverse electron transport. Production of superoxide by complex I during reverse electron transport is at least 3fold more sensitive to the pH gradient than to the membrane potential
-
-
?
additional information
?
-
-
superoxide production rates by complex I during reverse electron transfer are much greater than during forwards electron transfer. The major site of superoxide production in complex I is the quinpone-binding site, it is most likely a semiquinone
-
-
?
additional information
?
-
-
hexaammineruthenium (III) chloride, i.e. HAR, can act as artificial electron acceptor. The rate of NADH oxidation by the artificial electron acceptor HAR is about 10fold higher than NADH oxidase activity and is insensitive to rotenone and piericidin
-
-
?
additional information
?
-
-
no redox-coupled Na+ transport and no Na+/H+ antiporter function by the enzyme from Yarrowia lipolytica
-
-
?
additional information
?
-
-
the enzyme shows also rotenone-insensitive NADH:hexaammineruthenium III (HAR) oxidoreductase activity
-
-
?
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(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxy-5-propyloctyl]octahydro-2,2'-bifuran-5-yl]-5-propylnonan-1-ol
-
IC50: 870 nM
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyethyl]octahydro-2,2'-bifuran-5-yl]undecan-1-ol
-
IC50: 280 nM
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyheptyl]octahydro-2,2'-bifuran-5-yl]pentadecan-1-ol
-
IC50: 34 nM
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyheptyl]octahydro-2,2'-bifuran-5-yl]undecan-1-ol
-
IC50: 3.2 nM
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxynonyl]octahydro-2,2'-bifuran-5-yl]tridecan-1-ol
-
IC50: 7.5 nM
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxypropyl]octahydro-2,2'-bifuran-5-yl]undecan-1-ol
-
IC50: 45 nM
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundec-3-yn-1-yl]octahydro-2,2'-bifuran-5-yl]dodec-4-yn-1-ol
-
-
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]dodecan-1-ol
-
-
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]undeca-3,5,7,9-tetrayn-1-ol
-
IC50: 0.000172 mM
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-5-ethyl-1-hydroxyoctyl]octahydro-2,2'-bifuran-5-yl]undecan-1-ol
-
IC50: 27 nM
(1R)-5-ethyl-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxy-5-propyloctyl]octahydro-2,2'-bifuran-5-yl]octan-1-ol
-
IC50: 1500 nM
(1R,1'R)-1,1'-((2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyl)-bis-(6-(4-n-butylphenoxy)hex-3-yn-1-ol)
-
-
(1R,1'R)-1,1'-((2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyl)-bis-(6-(4-n-butylphenoxy)hexan-1-ol)
-
-
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diylbis(5-[4-[(E)-(4-butylphenyl)diazenyl]phenoxy]pentan-1-ol)
-
48 nM, 70% inhibition
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diylbis(5-[4-[(Z)-(4-butylphenyl)diazenyl]phenoxy]pentan-1-ol)
-
48 nM, 70% inhibition
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diylbis[6-(2-butylphenoxy)hexan-1-ol]
-
IC50: 1000 nM
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diylbis[6-(4-butylphenoxy)hexan-1-ol]
-
IC50: 0.83 nM
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyldihexan-1-ol
-
IC50: 4500 nM
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyldioctan-1-ol
-
IC50: 45 nM
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyldiundecan-1-ol
(1R,1'S)-1,1'-(2R,5R)-tetrahydrofuran-2,5-diylditridecan-1-ol
(5S)-3-[(10R)-10-hydroxy-10-[(2R,2'R,5R,5'R)-5'-[(1R)-1 hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]decyl]-5-methylfuran-2(5H)-one
-
IC50: 0.0000012 mM
(5S)-3-[(13R)-13-hydroxy-13-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]tridec-8-yn-1-yl]-5-methylfuran-2(5H)-one
-
IC50: 0.00000083 mM
(5S)-3-[(13R)-13-hydroxy-13-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]trideca-4,6,8,10-tetrayn-1-yl]-5-methylfuran-2(5H)-one
-
IC50: 0.0000017 mM
(5S)-3-[(13R)-13-hydroxy-13-[(2R,2'R,5R,5'R)-5'-[(1S)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]tridec-10-yn-1-yl]-5-methylfuran-2(5H)-one
-
IC50: 0.000001 mM
(5S)-3-[(13R)-13-hydroxy-13-[(2R,2'R,5R,5'R)-5'-[(1S)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]tridec-4-yn-1-yl]-5-methylfuran-2(5H)-one
-
IC50: 0.00000085 mM
(5S)-3-[(13R)-13-hydroxy-13-[(2R,5R)-5-[(1S)-1-hydroxytridecyl]tetrahydrofuran-2-yl]trideca-4,6,8,10-tetrayn-1-yl]-5-methylfuran-2(5H)-one
-
IC50: 0.00028 mM
(5S)-3-[(13R)-13-hydroxy-13-[(2R,5R)-5-[(1S)-1-hydroxytridecyl]tetrahydrofuran-2-yl]tridecyl]-5-methylfuran-2(5H)-one
-
IC50: 0.0000023 mM
(5S)-3-[(13S)-13-hydroxy-13-[(2R,5R)-5-[(1S)-1-hydroxytriecyl]tetrahydrofuran-2-yl]tridecyl]-5-methylfuran-2(5H)-one
-
IC50: 0.0000051 mM
(5S)-3-[(16R)-16-hydroxy-16-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]hexadecyl]-5-methylfuran-2(5H)-one
-
IC50: 0.000013 mM
(5S)-3-[(19R)-19-hydroxy-19-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]nonadecyl]-5-methylfuran-2(5H)-one
-
IC50: 0.000271 mM
(5S)-3-[(2E,13R)-13-hydroxy-13-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]tridec-2-en-4-yn-1-yl]-5-methylfuran-2(5H)-one
-
IC50: 0.0000011 mM
(5S)-3-[(5R)-5-hydroxy-5-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]pentyl]-5-methylfuran-2(5H)-one
-
IC50: 0.000014 mM
(5S)-3-[(7E,13S)-13-hydroxy-13-[(2R,5R)-5-[(1S)-1-hydroxytridecyl]tetrahydrofuran-2-yl]tridec-7-en-9-yn-1-yl]-5-methylfuran-2(5H)-one
-
IC50: 0.0000052 mM
(5S)-3-[(8E,13R)-13-hydroxy-13-[(2R,2'R,5R,5'R)-5'-[(1S)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]tridec-8-en-10-yn-1-yl]-5-methylfuran-2(5H)-one
-
IC50: 0.00000092 mM
(5S)-3-[(8R)-8-hydroxy-8-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]octyl]-5-methylfuran-2(5H)-one
-
IC50: 0.0000016 mM
(5S)-3-[4-[(E)-(4-[[(4R)-4-hydroxy-4-[(2R,5R)-5-[(1R)-1-hydroxytridecyl]tetrahydrofuran-2-yl]butyl]oxy]phenyl)diazenyl]benzyl]-5-methylfuran-2(5H)-one
-
-
(5S)-3-[4-[(E)-(4-[[(7R)-7-hydroxy-7-[(2R,5R)-5-[(1R)-1-hydroxytridecyl]tetrahydrofuran-2-yl]heptyl]oxy]phenyl)diazenyl]benzyl]-5-methylfuran-2(5H)-one
-
-
(5S)-3-[4-[(Z)-(4-[[(4R)-4-hydroxy-4-[(2R,5R)-5-[(1R)-1-hydroxytridecyl]tetrahydrofuran-2-yl]butyl]oxy]phenyl)diazenyl]benzyl]-5-methylfuran-2(5H)-one
-
-
(5S)-3-[4-[(Z)-(4-[[(7R)-7-hydroxy-7-[(2R,5R)-5-[(1R)-1-hydroxytridecyl]tetrahydrofuran-2-yl]heptyl]oxy]phenyl)diazenyl]benzyl]-5-methylfuran-2(5H)-one
-
-
1-(4-(4-nitrophenyl)piperazin-1-yl)-4-(thiophen-2-yl)butan-1-one
-
compound inhibits NADH:ubiquinone oxidoreductase, does stimulate glucose uptake in vitro
-
1-Geranyl-2-methylbenzimidazole
-
0.001 mM, 87% inhibition
1-hydroxy-2-octyl-4(1H)quinolone
-
-
1-methyl-4-phenylpyridinium
-
complex I inhibitor, which has no effect on mediobasal hypothalamic tuberoinfundibular dopamine neurons, but significantly increases the percentage of apoptag immunoreactive neurons in midbrain primary nigrostriatal dopamine and mesolimbic dopamine cultures
1-methyl-4-phenylpyridinium ion
-
inhibition of mitochondrial complex I. Neuroprotective effects of caffeine in the MPP+ model of apoptosis are mediated through activation of the ataxia telangiectasia mutated enzyme/p53 pathway. Caffeine decreases the expression of cyclin D and the transcription factor E2F-1, a regulator of apoptosis in neurons. Caffeine-mediated neuroprotection is not mediated through blockade of adenosine receptors because DPCPX and CGS-15943, two antagonists of these receptors, fail to attenuate apoptosis produced by 1-methyl-4-phenylpyridinium ion treatment
2',3'-dideoxycytidine
-
0.001 mM prevents the phosphorylation of the NDUFB11 subunit of complex I
2,3-dimethoxy-5-methyl-6-[(6-methylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]benzo-1,4-quinone
-
0.00028 mM, NADH-coenzyme Q1 activity
2,6-dichlorophenolindophenol
-
-
2-(4-butylbenzylamino)-3-methylchromen-4-one
-
-
2-(4-butylbenzyloxy)-3-methylchromen-4-one
-
-
2-decyl-4-quinazolinyl amine
2-n-decyl-4-quinazolinylamine
-
0.001 mM, 73% inhibition
2-n-decyl-quinazolin-4-yl-amine
transport is completely sensitive to 2-n-decyl-quinazolin-4-yl-amine
2-n-decyl-quinazoline-4-yl-amine
-
IC50: 0.0004 mM
2-n-heptyl-4-hydroxyquinoline-N-oxide
-
2-[(2,6-dimethylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzo-1,4-quinone
-
0.00077 mM, NADH-coenzyme Q1 activity
2-[(4-butylbenzyl)sulfanyl]-3-methyl-4H-chromen-4-one
-
-
2-[(6-chloro-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzo-1,4-quinone
-
0.00065 mM, NADH-coenzyme Q1 activity
2-[(6-chloro-2-methylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzo-1,4-quinone
-
0.00025 mM, NADH-coenzyme Q1 activity
2-[(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzo-1,4-quinone
-
0.00096 mM, NADH-coenzyme Q1 activity
2-[4-(4-fluorobutyl)benzylamino]-3-methylchromen-4-one
-
-
2-[4-(4-fluorobutyl)benzyloxy]-3-methylchromen-4-one
-
-
2-[4-(4-fluorobutyl)benzylsulfanyl]-3-methylchromen-4-one
-
most potent inhibitor. 30 min after high uptake of the radiotracer from the blood pool into the myocardium, kidney, and liver. After 2 h about 66% of the activity in the myocardium at 30 min has been retained, whereas ca. 70% has been cleared from the liver and kidney
3'-azido-3'-deoxythymidine
-
0.01 and 0.05 mM prevent the phosphorylation of the NDUFB11 subunit of complex I. This is associated with a decrease in complex I activity
3'-azido-3'-deoxythymidine monophosphate
-
0.15 mM prevents the phosphorylation of the NDUFB11 subunit of complex I. This is associated with a decrease in complex I activity
3,3'-methylene-bis(4-hydroxycoumarin)
-
-
3-(thiophen-2-ylthio)-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)propan-1-one
-
compound effectively stimulates glucose uptake in vitro and inhibits NADH:ubiquinone oxidoreductase
-
37-methoxyquinoxalinone
-
IC50: 10 nM
39-pyridopyrazinone
-
IC50: 17 nM
4-(4-benzyl-phenoxy)-N-(3,4-dimethoxy-benzyl)-benzamide
-
-
4-(4-tert-butyl-phenoxy)-N-(3,4-dimethoxy-benzyl)-benzamide
4-(thiophen-2-yl)-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)butan-1-one
-
compound effectively stimulates glucose uptake in vitro 2.57fold and inhibits NADH:ubiquinone oxidoreductase. Compound will not provoke adverse drug-drug interactions, yet be readily metabolised, avoid rapid excretion, with a short half-life, and have good tissue distribution
-
4-(thiophen-2-yl)-1-(4-(4-(trifluoromethyl)phenyl)piperidin-1-yl)butan-1-one
-
compound effectively stimulates glucose uptake in vitro and inhibits NADH:ubiquinone oxidoreductase
-
5-(N-ethyl)-N-isopropylamiloride
-
IC50 : 0.1 mM
5-(N-ethyl-N-isopropyl)-amiloride
-
0.015 mM, up to 40% decrease in the proton pumping activity of the wild-type and subunit NuoL mutants D303A, D400A, D400E, no significant change in mutant D178N
5-(N-ethyl-N-isopropyl)amiloride
5-fluoro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)-phenyl)quinolin-4(1H)-one
inhibitor exhibits potency against both drug-resistant strains in vitro and parasite-infected mice in vivo via a potential allosteric mechanism. Inhibitor can be used in combination with dihydroartemisinin synergistically
5-phenyl-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)pentan-1-one
-
compound effectively stimulates glucose uptake in vitro and inhibits NADH:ubiquinone oxidoreductase
-
5BM-GX
-
inhibits transhydrogenation reaction with NADH and 3'-acetyl pyridine adenine dinucleotide
6-amino-4-(4-tert-butylphenethylamino)quinazoline
6-azido-4-(4-iodophenethylamino)quinazoline
6-azido-N-[2-(4-tert-butylphenyl)ethyl]-6,7-dihydroquinazolin-4-amine
-
9-amino-6-chloro-2-methoxyacridine
-
0.0005 mM
AMP
-
dead-end inhibitor, linear competitive inhibitor of NADH, linear uncompetitive inhibitor of oxidized 2,6-dichlorophenol indophenol
AMS-GX
-
inhibits transhydrogenation reaction with NADH and 3'-acetyl pyridine adenine dinucleotide
Amytal
-
0.5 mM, 50% inhibition
arylazido-beta-alanyl-NAD+
-
competitive inhibition towards NADH and ferricyanide
atovaquone
-
20 nM, complete inhibition of partially purified enzyme. Inhibition of complex I represents a likely mechanism of the known antileishmanial activity of the drug
benzimidazole
-
0.001 mM, 72% inhibition
benzo (1,2,3) thiadiazole-7-carbothioic acid S-methyl ester
-
0.075 mM, strong inhibition
benzoxazinone
-
0.001 mM, 76% inhibition
bis-tetrahydrofuran acetogenin
-
the additional methylenes enhance the hydrophobicity of the spacer region, which may be thermodynamically advantageous for bringing the polar gamma-lactone ring into the membrane-embedded segment of complex I
-
carbonyl-cyanide-p-trifluoro-methoxy-phenylhydrazone
-
0.001 mM
carvedilol
-
decreases mitochondrial complex I activity, which is associated with an increase in mitochondrial H2O2 production, total glutathione and protein thiols content
Cd2+
-
1 mM, potent inhibitor
dicyclohexylcarbodi-imide
-
90% inhibition, IC50: 0.25 mM
Dicyclohexylcarbodiimide
-
-
diphenyl iodonium
-
maximal inhibition after preincubation with NADH, more complete inhibition with the more hydrophobic electron acceptors such as ubiquinone-1 or ubiquinone-2 as electron acceptor compared to the more hydrophilic ones, such as ubiquinone-0 or dichloroindophenol
diphenyl iodonium chloride
-
0.001 mM and above
diphenyleineiodonium
-
does not inhibit superoxide generation
diphenylene iodinium chloride
-
-
diphenylene iodonium
-
75% inhibition, IC50: 0.013 mM
diphenylene iodonium chloride
-
0.001 mM and above
diphenyleneiodonium
-
strongly inhibits superoxide production by complex I driven by reverse electron transport from succinate. Inhibition of superoxide production is not dependent on changes in the pH gradient. The inhibitor does not react with the flavin of complex I
DL-homocysteic acid
-
marked (ca. 64%) decrease of respiratory chain complex I activity in the cerebral cortex of immature rats following seizures induced by bilateral intracerebroventricular infusion of DL-homocysteic acid (600 nanomol/side). Decrease is already evident during the acute phase of seizures (60-90 min after infusion) and persists for at least 20 h after the seizures. Inhibition is selective for complex I since activities of complex II and IV and citrate synthase remain unaffected. Inhibition of complex I activity is not associated with changes in complex I content. Enhanced production of reactive oxygen species by inhibited complex I in mitochondria from DL-homocysteic acid-treated animals. Competitive NMDA receptor antagonist AP7, a selective and potent group II mGluR agonist (2R,4R)-APDC and a highly selective group III mGluR, subtype 8, agonist (S)-3,4-DCPG, significantly reduce the extent of complex I inhibition. The superoxide dismutase mimetic Tempol and a selective peroxynitrite scavenger and decomposition catalyst FeTPPS provide a significant attenuation of complex I inhibition associated with DL-homocysteic acid-induced seizures
dodecyl-beta-D-maltoside
-
leads to immediate loss of activity
doxorubicin
-
maximal inhibition at 0.001 mM
ferricyanide
-
inhibits the interaction of the oxidized enzyme with NADH
flutamide
-
inhibits complex I of the electron transport chain to a greater extent than a nitro to cyano analogue of flutamide. As compared to the nitro to cyano analogue of flutamide, the nitroaromatic group of flutamide enhances cytotoxicity to hepatocytes, likely through mechanisms involving mitochondrial dysfunction and ATP depletion that include complex I inhibition
imidazole
-
0.001 mM, 75% inhibition
liponox DCH
-
inhibitory at concentrations higher than 0.02%
Mersalyl
-
0.3 mM, 77% inhibition of NADH-ubiquinone-1 reductase activity, 96% inhibition of NADH-potassium ferricyanide reductase activity
Mg2+
-
inhibition of the enzyme in its inactive form, in its active form the enzyme complex is not sensitive
N,N'-dicyclohexylcarbodiimide
-
2 mM, 71% inhibition
N-(3,4-dimethoxy-benzyl)-4-[4-(1,1-dimethyl-propyl)-phenoxy]-benzamide
-
-
NEM
-
inhibition of the enzyme in its inactive form, in its active form the enzyme complex is not sensitive
Ni2+
-
1 mM, potent inhibitor
oxygen
-
O2 induces self-inactivation of the enzyme via the formation of protein radicals
p-chloromercuriphenyl sulfonic acid
-
0.1 mM, 50% inhibition
palmitate
-
IC50: 0.009 mM, at 25°C and pH 8.0
quinoxalinone
-
0.001 mM, 79% inhibition
reduced 2,6-dichlorophenolindophenol
-
-
reduced coenzyme Q1
-
product inhibition
Rhein
-
i.e. 4,5-dioxy-anthraquinone-z-carbonic acid, competes for a NADH-binding site
salicylic acid
-
0.5 mM, 45% inhibition
squamocin M
-
IC50: 0.00000085 mM
squamocin-quinoxalinone
-
-
Trifluoperazine
-
0.05 mM
vanillylnonanamide
-
0.4 mM
YLVCGERGFFYTPKA
-
hypoxia causes prolonged inhibition of maximal complex I activity and ultrastructural phenotypes associated with swelling, namely, fading of cristae, intracristal dilations and membrane disruption. Administration of the selective neuronal nitric oxide synthase inhibitor 7-nitroindazole 20 min before hypoxia prevents complex I inhibition in a dose-dependent manner and most ultrastructural damage
[2-(4-butyl)benzylsulfanyl]-3-methylchromen-4-one
-
-
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyldiundecan-1-ol
-
IC50: 0.0000016 mM
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyldiundecan-1-ol
-
IC50: 1.6 nM
(1R,1'S)-1,1'-(2R,5R)-tetrahydrofuran-2,5-diylditridecan-1-ol
-
IC50: 0.025 mM
(1R,1'S)-1,1'-(2R,5R)-tetrahydrofuran-2,5-diylditridecan-1-ol
-
IC50: 9.0 nM
2-decyl-4-quinazolinyl amine
-
the compound is both a complex I inhibitor and an uncoupler
2-decyl-4-quinazolinyl amine
-
-
2-decyl-4-quinazolinyl amine
-
0.00022 mM
2-decyl-4-quinazolinyl amine
-
0.002 mM, strong inhibitor
3-azido-ubiquinone-2
-
4-(4-tert-butyl-phenoxy)-N-(3,4-dimethoxy-benzyl)-benzamide
-
-
4-(4-tert-butyl-phenoxy)-N-(3,4-dimethoxy-benzyl)-benzamide
-
-
5-(N-ethyl-N-isopropyl)amiloride
-
-
5-(N-ethyl-N-isopropyl)amiloride
inhibits of complex I and increases the membrane conductivity
6-amino-4-(4-tert-butylphenethylamino)quinazoline
-
6-amino-4-(4-tert-butylphenethylamino)quinazoline
-
-
6-azido-4-(4-iodophenethylamino)quinazoline
the compound specifically binds to the 49000 Da and ND1 subunits with a frequency of about 4:1
6-azido-4-(4-iodophenethylamino)quinazoline
-
the compound specifically binds to the 49000 Da and ND1 subunits with a frequency of about 4:1
ADP-ribose
-
competitive with NADH
ADP-ribose
-
ADP-ribose acts as mixed-type inhibitors for NADH, ferricyanide and 5,8-dioxy-1,4-naphthoquinone
ADP-ribose
-
competitive with NADH
benzamil
-
-
bullatacin
-
IC50: 0.00000083 mM
bullatacin
-
potent inhibitor
Ca2+
-
1 mM
Ca2+
-
inhibits complex I activity in a concentration-dependent manner. Ca2+ acts specifically on complex I. Complex I inactivation by Ca2+ results in reduction of NADH-supported electron transport activity and suppression of the rate of O2- production
capsaicin
-
no inhibition of enzymes where the energy couling site is absent
capsaicin
-
and synthetic capsaicin analogue. Several synthetic capsaicins discriminate between NDH-1 and NDH-2 much better than natural capsaicin
capsaicin
-
inhibition of enzymes involved in energy coupling site
capsaicin
-
and synthetic capsaicin analogue. Several synthetic capsaicins discriminate between NDH-1 and NDH-2 much better than natural capsaicin
capsaicin
-
inhibition of enzymes involved in energy coupling site
capsaicin
-
0.3 mM, 88% inhibition
capsaicin
-
inhibition of enzymes involved in energy coupling site
capsaicin
-
no inhibition of enzymes where the energy couling site is absent
capsaicin
-
and synthetic capsaicin analogue. Several synthetic capsaicins discriminate between NDH-1 and NDH-2 much better than natural capsaicin
capsaicin
-
inhibition of enzymes involved in energy coupling site
colistin
-
-
fenpyroximate
-
fenpyroximate
-
deactive but not active complex I is a Na+/H+ antiporter that can be inhibited by fenpyroximate
flavone
-
0.165 mM, 50% reduction of activity with duroquinone
flavone
-
dead-end inhibitor; partial inhibitor displaying a hyperbolic uncompetitive inhibition with respect to oxidized 2,6-dichlorophenol indophenol
metformin
-
inhibits complex I activity, associated with LPS-induced neutrophil activation. Metformin prevents LPS-induced acute lung injury
metformin
-
inhibits the activity of NADH:ubiquinone oxidoreductase (complex I) and decreases production of the pro-form of the inflammatory cytokine IL-1beta in response to lipopolysaccharide in macrophages. Metformin specifically inhibits pro-IL-1beta production, having no effect on TNF-alpha
Myxothiazol
-
IC50: 170 nM
Myxothiazol
-
complex I Q-reduction site inhibitor
N-ethylmaleimide
-
0.5 mM, strong inhibition
N-ethylmaleimide
-
0.5 mM, strong inhibition
NAD+
-
4 mM, 19% inhibition of NADH-ubiquinone-1 reductase activity
NAD+
-
product inhibition
NAD+
-
NAD+ acts as a mixed-type inhibitor for both substrates in the NADH: ferricyanide reductase reaction of complex I
NAD+
-
NAD+ acts as mixed-type inhibitors for NADH, ferricyanide and 5,8-dioxy-1,4-naphthoquinone. At saturating concentrations of oxidizer, NAD+ acts as a competitive inhibitor for NADH
NADH
-
inhibits the interaction of the reduced enzyme with ferricyanide
NADH
-
NADH acts as a competitive inhibitor for ferricyanide, the reactions of with quinones and nitro compounds are not inhibited by NADH
NADH
-
NADH acts as a competitive inhibitor for 5,8-dioxy-1,4-naphthoquinone, NADH acts as a linear competitive inhibitor for ferricyanide
piercidin A
-
-
piericidin
-
the residual activity in the presence of saturating palmitate is completely (>90%) inhibited by piericidin
piericidin
-
complex I Q-reduction site inhibitor
piericidin
-
specific inhibitor of ubiquinone reduction
Piericidin A
-
0.0023 mM
Piericidin A
-
IC50: 0.0000013 mM
Piericidin A
-
degree of inhibition for the reaction with decylubiquinone is higher than for the reaction with ubiquinone-1 as electron acceptor
Polymyxin B
-
-
Polymyxin B
-
mixed inhibition with respect to ubiquinone-1 and non-competitive inhibition with respect to NADH
Polymyxin B
-
in the presence of polymyxin B, enzyme kinetics changes from the MichaelisMenten type to substrate inhibition kinetics with the substrate inhibition
pyridaben
-
-
pyridabene
-
rolliniastatin
-
strong inhibitor
rolliniastatin-2
-
-
rolliniastatin-2
-
0.001 mM, 92% inhibition
rotenone
-
IC50: 0.002 mM
rotenone
-
150 nM, 85% inhibition in presence of 0.01 mM NADH, inhibition is independent of coenzyme Q1 concentration below 0.05 mM, rotenone sensitivity decreases significantly with coenzyme Q1 concentration above 0.1 mM
rotenone
-
0.001 mM, 90% inhibition
rotenone
-
0.001 mM, 90% inhibition
rotenone
-
0.01 mM, complete inhibition
rotenone
-
0.002 mM rotenone diminishes the bimolecular rate constant value for tetramethyl-1,4-benzoquinone and for 2,5-dimethyl-1,4-benzoquinone by 30 and 10%, respectively
rotenone
-
deactive but not active complex I is a Na+/H+ antiporter that can be inhibited by rotenone
rotenone
-
RCC-I inactivation causes a dramatic decrease in mitochondrial NO that is not affected by Mn (III) porphyrin 5,10,15,20-tetrakis(benzoic acid) porphyrin. RCC-I inactivation drastically increases mitochondrial reactive oxygen species, which is prevented when mitochondrial nitric oxide synthase is inhibited or cells are treated with Mn (III) porphyrin 5,10,15,20-tetrakis(benzoic acid) porphyrin. Inactivation of RCC-I in SHSY cells dramatically increases tyrosine nitration of mitochondrial proteins that is fully prevented when mitochondrial nitric oxide synthase is inactivated. RCC-I inactivation leads cytochrome c to diffuse into the cytoplasm indicating its release from the mitochondria
rotenone
-
when complex I activity is chronically reduced by 80% using 100 nanomol rotenone, the percentage of moving mitochondria decreases from 79% to 50% and reduce their velocity by 30%
rotenone
-
reduces complex I activity, which is accompanied by increasing production of cellular superoxide
rotenone
-
inhibits complex I followed by apoptosis. 40% decrease of dopamine content suppresses rotenone-induced apoptosis. 30% increase of dopamine content by inhibition of dopamine metabolism enhances rotenone-induced apoptosis. Depletion of intracellular dopamine using reserpine (0.0001-0.01 mM) also prevents rotenone-induced apoptosis, and this effect is counteracted by dopamine (0.01-0.1 mM) replenishment. Inhibition of dopamine reverse transport increases cytosolic dopamine and enhances rotenone-induced apoptosis. Rotenone induces dopamine redistribution from vesicles to the cytosol. Rotenone stimulates reactive oxygen species and protein carbonylation and decreases the antioxidant glutathione. Addition of the antioxidant N-acetylcysteine (3 mM), prevents dopamine being expelled from vesicles and inhibits rotenone-induced apoptosis
rotenone
-
inhibits complex I, which is associated with increased ROS generation, LPS-induced nuclear translocation of NF-kappaB and cytokine production in neutrophils. Rotenone pretreatment attenuates LPS-induced acute lung injury
rotenone
-
is a more potent inhibitor of complex I than flutamide. Inhibits complex I of the electron transport chain to a greater extent than a nitro to cyano analogue of flutamide
rotenone
-
completely obstructs electron transfer through complex I
rotenone
-
complex I inhibitor, which has no effect on mediobasal hypothalamic tuberoinfundibular dopamine neurons, but significantly increases the percentage of apoptag immunoreactive neurons in midbrain primary nigrostriatal dopamine and mesolimbic dopamine cultures
rotenone
-
inhibits the activity of NADH:ubiquinone oxidoreductase (complex I) and decreases production of the pro-form of the inflammatory cytokine IL-1beta in response to lipopolysaccharide in macrophages
rotenone
-
mitochondria contain two different NADH:ubiquinone reductases. One enzyme oxidizes endogenous NADH, couples electron transfer to proton translocation and is inhibited by rotenone, the other enzyme oxidizes exogenous NADH without proton tranlocation and is insensitive to rotenone. The activity of the rotenone-insensitive enzyme highly exceeds the activity of the rotenone-sensitive enzyme
rotenone
-
100 nM, complete inhibition
rotenone
-
inhibition of NADH oxidation, NAD+ reduction is not inhibited by 0.001 mM rotenone
rotenone
-
0.001-0.01 mM, 50-75% inhibitio in mitochondrial lysate. Inhibition of complex I represents a likely mechanism of the known antileishmanial activity of the drug
rotenone
-
when RCC-I is inactivated, mitochondrial nitric oxide synthase stimulation dramatically augments the superoxide signal, whereas augmented superoxide signal is prevented when mitochondrial nitric oxide synthase is inhibited and abolished by superoxide dismutase. RCC-I inactivation dramatically increases S-nitrosoglutathione decomposition that is prevented when mitochondrial nitric oxide synthase is inhibited. RCC-I inactivation increases tyrosine-nitrated mitochondrial proteins, causes cytochrome c release and aggregation of mitochondria
rotenone
-
decreases complex I activity by 25%, 27% and 48% in the presence of 0.005, 0.01 and 0.02 mM carvedilol, respectively
rotenone
-
strongly inhibits superoxide production by complex I
rotenone
-
rotenone-induced increment of H2O2 production is 2fold higher upon DL-homocysteic acid-treatment, thus clearly indicating elevated production of reactive oxygen species at complex I
rotenone
-
rotenone-insensitive enzyme
rotenone
-
specific inhibitor of ubiquinone reduction
rotenone
-
rotenone-insensitive enzyme
rotenone
-
does not inhibit superoxide generation
squamocin
-
-
squamocin
-
0.001 mM, 88% inhibition
Triton X-100
-
specific inhibitor of ubiquinone reduction by complex I
Triton X-100
-
leads to immediate loss of activity
Zn2+
-
pH-dependent potent inhibitor, IC50: 0.01-0.05 mM at pH 7.5, depending on the enzyme state, Zn2+ does not inhibit NADH oxidation or intramolecular electron transfer, so it probably inhibits either proton transfer to bound quinone or proton translocation.
Zn2+
-
at 2 mM Zn2+, proton pumping of the wild-type is selectively inhibited without affecting electron transfer, no inhibition in proton pumping of mutants D178N and D400A
Zn2+
0.1 mM, reversible stabilization of inactive form
additional information
-
insensitive to 0.5 mM 5,5-dithiobis-(2-nitrobenzoate) and 10 mM oxidized glutathione at pH 8.0
-
additional information
-
not inhibited by ferricyanide above 1 mM
-
additional information
-
the oxidation of NADH by 5,8-dioxy-1,4-naphthoquinone, catalyzed by complex I is completely insensitive to 0.002 mM rotenone
-
additional information
-
inhibition of flavin-site reactions by NADH analogues and fragments, overview
-
additional information
-
when NADH, ADP, ATP and ADP-ribose bind to the reduced flavin they stimulate paraquat and HAR reduction, but inhibit FeCN, APAD+ and O2 reduction
-
additional information
-
capsaicin, the DELTAlac-acetogenin, 1-methyl-4-phenyl-pyridinium, piericidin A, ranolazine, and stigmatellin have no effect on the antiporter activity, whereas fenpyroximate (as well as rotenone) inhibited it
-
additional information
-
in m.1627A animals, the enzyme activity value under normal oxygen is significantly higher than that under simulated hypoxia
-
additional information
-
COX I mutant cybrids show a 80% reduction in complex I enzymatic activity in isolated mitochondria as compared with control cybrids
-
additional information
-
no inhibition by rotenone up to 0.25 mM and flavone
-
additional information
-
mouse cell lines with suppressed expression of the nuclearly encoded subunit 4 of complex IV associated with a loss of assembly of complex IV show significantly reduced level of assembled complex I and activity, whereas levels and activity of complex III are normal or up-regulated
-
additional information
-
insensitive to rotenone
-
additional information
-
no inhibition: dibenziodolium chloride, diphenyliodonium chloride, 1-hydroxy-2-dodecyl-4(1H)quinolone, atovaquone, antimycin A, rotenone, flavone, artemisinin
-
additional information
-
insensitive to 0.5 mM 5,5-dithiobis-(2-nitrobenzoate) and 10 mM oxidized glutathione at pH 8.0
-
additional information
-
inhibition of mitochondrial complex I by serum and potassium deprivation. Caffeine does not exert neuroprotective effects after serum and potassium withdrawal, a p53-independent model of apoptosis
-
additional information
not inhibitory: rotenone; not inhibitory: rotenone
-
additional information
not inhibitory: rotenone; not inhibitory: rotenone
-
additional information
-
not inhibitory: rotenone; not inhibitory: rotenone
-
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0.55 - 1
1,1'-carbamoylmethylviologen
0.4
1,4-benzoquinone
-
pH 7.0, 25°C
0.0434
2,3-dimethoxy-5-methyl-6-[(6-methyl-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-yl)methyl]benzo-1,4-quinone
-
-
0.3598
2,3-dimethoxy-5-methyl-6-[(6-methylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]benzo-1,4-quinone
-
-
0.0417
2,3-dimethoxy-5-methyl-6-[(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]benzo-1,4-quinone
-
-
0.4
2,5-dimethyl-1,4-benzoquinone
-
pH 7.0, 25°C
0.03348
2-[(2,6-dimethylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzo-1,4-quinone
-
-
0.221
2-[(2-chloro-6-methylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzo-1,4-quinone
-
-
0.01683
2-[(2-chloro-6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzo-1,4-quinone
-
-
0.4144
2-[(6-chloro-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzo-1,4-quinone
-
-
0.417
2-[(6-chloro-2-methylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzo-1,4-quinone
-
-
0.227
2-[(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-5,6-dimethoxy-3-methylbenzo-1,4-quinone
-
-
0.125
3'-acetyl pyridine adenine dinucleotide
-
pH 8.0, 26°C
0.08
5,8-dioxo-1,4-naphthoquinone
-
pH 7.0, 25°C
0.12
5-oxo-1,4-naphthoquinone
-
pH 7.0, 25°C
0.09
9,10-phenanthrenequinone
-
pH 7.0, 25°C
0.0004
deamino-NADH
-
pH 8.0, 26°C
0.024 - 43
decylubiquinone
0.012 - 0.0684
ferricytochrome c
0.007 - 0.039
n-decylubiquinone
0.0062 - 0.55
oxidized 2,6-dichlorophenolindophenol
0.0046
oxidized dichlorophenolindophenol
-
pH 8.0, 25°C
-
0.104 - 0.35
ubiquinone-0
0.0032 - 0.083
ubiquinone-2
additional information
additional information
-
0.55
1,1'-carbamoylmethylviologen
-
-
1
1,1'-carbamoylmethylviologen
-
-
0.01
coenzyme Q1
-
pH 8.0, 25°C
0.015
coenzyme Q1
-
pH 8.0, 25°C
0.02
coenzyme Q1
-
pH 8.0, 25°C
0.024
decylubiquinone
-
using 0.1 mM NADH at pH 7.5
0.066
decylubiquinone
-
-
2 - 3
decylubiquinone
-
mutant enzyme V206E
2 - 3
decylubiquinone
-
mutant enzyme Y229H
25
decylubiquinone
-
mutant enzyme H210T
33
decylubiquinone
-
mutant enzyme D213E
34
decylubiquinone
-
mutant enzyme D213N
37
decylubiquinone
-
mutant enzyme R209F
40
decylubiquinone
-
mutant enzyme E228D
43
decylubiquinone
-
wild type enzyme
43
decylubiquinone
-
mutant enzyme E216A
0.055
ferricyanide
-
-
0.012
ferricytochrome c
-
-
0.036
ferricytochrome c
-
in the presence of 0.1 mM daunorubicin
0.0571
ferricytochrome c
-
in the presence of 0.1 mM mitoxantrone
0.0684
ferricytochrome c
-
in the presence of 0.1 mM ametantrone
0.002
menadione
-
pH 7.5, 30°C
0.017
menadione
pH 7.5, 60°C
0.032
menadione
pH 7.5, 60°C
0.239
menadione
-
pH 8.0, 25°C
0.1
menaquinone
-
-
0.1
menaquinone
-
pH 7.0, temperature not specified in the publication
0.007
n-decylubiquinone
-
mutant P232G (49000 Da subunit)
0.012
n-decylubiquinone
-
mutant T157I (30000 Da subunit)
0.014
n-decylubiquinone
-
mutant R211W (30000 Da subunit)
0.016
n-decylubiquinone
-
mutant D228Q (49000 Da subunit)
0.017
n-decylubiquinone
-
mutant S416P (49000 Da subunit)
0.021
n-decylubiquinone
-
mutant F87L (49000 Da subunit)
0.029
n-decylubiquinone
-
mutant R231E (49000 Da subunit)
0.039
n-decylubiquinone
-
mutant S416A (49000 Da subunit)
0.007
NAD+
-
pH 8.0, 25°C, succinate supported NAD+ reduction
0.27
NAD+
-
pH 8.0, 25°C, succinate supported NAD+ reduction
0.00005
NADH
-
apparent value, for superoxide production, at 32°C and pH 7.5
0.0014
NADH
-
coupled oxidase reaction, pH 8.0, 25°C
0.00172
NADH
-
with 0.01 mM coenzyme Q1
0.00195
NADH
-
with 0.025 mM coenzyme Q1
0.002
NADH
-
coupled oxidase reaction, pH 8.0, 25°C
0.002
NADH
-
with 0.05 mM coenzyme Q1
0.0022
NADH
-
uncoupled oxidase reaction, pH 8.0, 25°C
0.0027
NADH
-
pH 8.0, 26°C
0.005
NADH
-
in the presence of 1 mM ferricyanide
0.0051
NADH
-
using decylubiquinone as substrate
0.0057
NADH
-
mutant E183H, pH 6.0, 30°C
0.0058
NADH
-
mutant E183D, pH 6.0, 30°C
0.006
NADH
-
uncoupled oxidase reaction, pH 8.0, 25°C
0.007
NADH
-
reaction with ferricyanide
0.007
NADH
-
uncoupled oxidase reaction, pH 8.0, 25°C
0.012
NADH
-
mutant E183Q, pH 6.0, 30°C
0.013
NADH
-
wild-type enzyme, pH 6.0, 30°C
0.014
NADH
-
reaction with cytochrome c
0.014
NADH
-
mutant E183N, pH 6.0, 30°C
0.0167
NADH
-
using ubiquinone-1 as substrate
0.019
NADH
-
reaction with ubiquinone-1
0.031
NADH
-
with ubiquinone-6 as acceptor
0.0438
NADH
-
enzyme activated before assay, electron acceptor: ferricyanide
0.0452
NADH
-
electron acceptor: ferricyanide
0.0483
NADH
-
enzyme activated before assay, electron acceptor: ubiquinone-1
0.094
NADH
-
pH 7.6, 32°C, cosubstrate: ubiquinone-1, ubiquinone-0 or idebenone
0.0965
NADH
-
electron acceptor: ubiquinone-1
0.12
NADH
-
cosubstrate ubiquinone-2, pH 7.0, temperature not specified in the publication
0.132
NADH
-
pH 7.5, 30°C
0.14
NADH
-
cosubstrate ubiquinone-0, pH 7.0, temperature not specified in the publication
0.23
NADH
-
cosubstrate menaquinone, pH 7.0, temperature not specified in the publication
0.025
NADPH
-
mutant E183H, pH 6.0, 30°C
0.045
NADPH
-
mutant E183Q, pH 6.0, 30°C
0.39
NADPH
-
mutant E183D, pH 6.0, 30°C
0.48
NADPH
-
mutant E183N, pH 6.0, 30°C
1.87
NADPH
-
wild-type enzyme, pH 6.0, 30°C
0.0062
oxidized 2,6-dichlorophenolindophenol
-
-
0.016
oxidized 2,6-dichlorophenolindophenol
-
-
0.55
oxidized 2,6-dichlorophenolindophenol
-
-
0.104
ubiquinone-0
-
pH 8.0, 25°C
0.35
ubiquinone-0
-
pH 7.0, temperature not specified in the publication
0.002
ubiquinone-1
-
pH 8.0, 25°C
0.0041
ubiquinone-1
-
at pH 7.0
0.015
ubiquinone-1
-
pH 7.4, 25°C
0.0349
ubiquinone-1
pH 7.0, 25°C
0.0032
ubiquinone-2
-
at pH 7.0
0.02
ubiquinone-2
-
pH 7.0, temperature not specified in the publication
0.0204
ubiquinone-2
-
using 0.1 mM NADH at pH 7.5
additional information
additional information
-
Km-value for NADH, decylubiquinone, coenzyme Q1 and coenzyme Q2 are measured at different concentrations of the cosubstrate
-
additional information
additional information
-
Km-values for decylubiquinone are measured at pH-values 6.5 and 9.0 at different concentrations of the cosubstrate NADH. Km-values for NADH are measured at pH values 6.5, 7.0, 7.5, 8.0, 8.5 and 9.0 and at different concentrations of the cosubstrate decylubiquinone
-
additional information
Ubiquinone-10
-
KM value for complex I is 3.9 nmol/mg phospholipid
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0.00087
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxy-5-propyloctyl]octahydro-2,2'-bifuran-5-yl]-5-propylnonan-1-ol
Bos taurus
-
IC50: 870 nM
0.00028
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyethyl]octahydro-2,2'-bifuran-5-yl]undecan-1-ol
Bos taurus
-
IC50: 280 nM
0.000034
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyheptyl]octahydro-2,2'-bifuran-5-yl]pentadecan-1-ol
Bos taurus
-
IC50: 34 nM
0.0000032
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyheptyl]octahydro-2,2'-bifuran-5-yl]undecan-1-ol
Bos taurus
-
IC50: 3.2 nM
0.0000075
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxynonyl]octahydro-2,2'-bifuran-5-yl]tridecan-1-ol
Bos taurus
-
IC50: 7.5 nM
0.000045
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxypropyl]octahydro-2,2'-bifuran-5-yl]undecan-1-ol
Bos taurus
-
IC50: 45 nM
0.000048
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundec-3-yn-1-yl]octahydro-2,2'-bifuran-5-yl]dodec-4-yn-1-ol
Bos taurus
-
-
0.0104
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]dodecan-1-ol
Bos taurus
-
-
0.000172
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]undeca-3,5,7,9-tetrayn-1-ol
Bos taurus
-
IC50: 0.000172 mM
0.000027
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-5-ethyl-1-hydroxyoctyl]octahydro-2,2'-bifuran-5-yl]undecan-1-ol
Bos taurus
-
IC50: 27 nM
0.0015
(1R)-5-ethyl-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxy-5-propyloctyl]octahydro-2,2'-bifuran-5-yl]octan-1-ol
Bos taurus
-
IC50: 1500 nM
0.0017
(1R,1'R)-1,1'-((2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyl)-bis-(6-(4-n-butylphenoxy)hex-3-yn-1-ol)
Bos taurus
-
-
0.001
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diylbis[6-(2-butylphenoxy)hexan-1-ol]
Bos taurus
-
IC50: 1000 nM
0.00000083
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diylbis[6-(4-butylphenoxy)hexan-1-ol]
Bos taurus
-
IC50: 0.83 nM
0.0045
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyldihexan-1-ol
Bos taurus
-
IC50: 4500 nM
0.000045
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyldioctan-1-ol
Bos taurus
-
IC50: 45 nM
0.0000016
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyldiundecan-1-ol
0.000009 - 0.025
(1R,1'S)-1,1'-(2R,5R)-tetrahydrofuran-2,5-diylditridecan-1-ol
0.0000012
(5S)-3-[(10R)-10-hydroxy-10-[(2R,2'R,5R,5'R)-5'-[(1R)-1 hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]decyl]-5-methylfuran-2(5H)-one
Bos taurus
-
IC50: 0.0000012 mM
0.00000083
(5S)-3-[(13R)-13-hydroxy-13-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]tridec-8-yn-1-yl]-5-methylfuran-2(5H)-one
Bos taurus
-
IC50: 0.00000083 mM
0.0000017
(5S)-3-[(13R)-13-hydroxy-13-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]trideca-4,6,8,10-tetrayn-1-yl]-5-methylfuran-2(5H)-one
Bos taurus
-
IC50: 0.0000017 mM
0.000001
(5S)-3-[(13R)-13-hydroxy-13-[(2R,2'R,5R,5'R)-5'-[(1S)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]tridec-10-yn-1-yl]-5-methylfuran-2(5H)-one
Bos taurus
-
IC50: 0.000001 mM
0.00000085
(5S)-3-[(13R)-13-hydroxy-13-[(2R,2'R,5R,5'R)-5'-[(1S)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]tridec-4-yn-1-yl]-5-methylfuran-2(5H)-one
Bos taurus
-
IC50: 0.00000085 mM
0.00028
(5S)-3-[(13R)-13-hydroxy-13-[(2R,5R)-5-[(1S)-1-hydroxytridecyl]tetrahydrofuran-2-yl]trideca-4,6,8,10-tetrayn-1-yl]-5-methylfuran-2(5H)-one
Bos taurus
-
IC50: 0.00028 mM
0.0000023
(5S)-3-[(13R)-13-hydroxy-13-[(2R,5R)-5-[(1S)-1-hydroxytridecyl]tetrahydrofuran-2-yl]tridecyl]-5-methylfuran-2(5H)-one
Bos taurus
-
IC50: 0.0000023 mM
0.0000051
(5S)-3-[(13S)-13-hydroxy-13-[(2R,5R)-5-[(1S)-1-hydroxytriecyl]tetrahydrofuran-2-yl]tridecyl]-5-methylfuran-2(5H)-one
Bos taurus
-
IC50: 0.0000051 mM
0.000013
(5S)-3-[(16R)-16-hydroxy-16-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]hexadecyl]-5-methylfuran-2(5H)-one
Bos taurus
-
IC50: 0.000013 mM
0.000271
(5S)-3-[(19R)-19-hydroxy-19-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]nonadecyl]-5-methylfuran-2(5H)-one
Bos taurus
-
IC50: 0.000271 mM
0.0000011
(5S)-3-[(2E,13R)-13-hydroxy-13-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]tridec-2-en-4-yn-1-yl]-5-methylfuran-2(5H)-one
Bos taurus
-
IC50: 0.0000011 mM
0.000014
(5S)-3-[(5R)-5-hydroxy-5-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]pentyl]-5-methylfuran-2(5H)-one
Bos taurus
-
IC50: 0.000014 mM
0.0000052
(5S)-3-[(7E,13S)-13-hydroxy-13-[(2R,5R)-5-[(1S)-1-hydroxytridecyl]tetrahydrofuran-2-yl]tridec-7-en-9-yn-1-yl]-5-methylfuran-2(5H)-one
Bos taurus
-
IC50: 0.0000052 mM
0.00000092
(5S)-3-[(8E,13R)-13-hydroxy-13-[(2R,2'R,5R,5'R)-5'-[(1S)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]tridec-8-en-10-yn-1-yl]-5-methylfuran-2(5H)-one
Bos taurus
-
IC50: 0.00000092 mM
0.0000016
(5S)-3-[(8R)-8-hydroxy-8-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]octyl]-5-methylfuran-2(5H)-one
Bos taurus
-
IC50: 0.0000016 mM
0.017
1-(4-(4-nitrophenyl)piperazin-1-yl)-4-(thiophen-2-yl)butan-1-one
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
-
0.057
2-(4-butylbenzylamino)-3-methylchromen-4-one
Rattus norvegicus
-
-
0.06
2-(4-butylbenzyloxy)-3-methylchromen-4-one
Rattus norvegicus
-
-
0.0004
2-n-decyl-quinazoline-4-yl-amine
Aquifex aeolicus
-
IC50: 0.0004 mM
0.052
2-[(4-butylbenzyl)sulfanyl]-3-methyl-4H-chromen-4-one
Rattus norvegicus
-
-
0.133
2-[4-(4-fluorobutyl)benzylamino]-3-methylchromen-4-one
Rattus norvegicus
-
-
0.033
2-[4-(4-fluorobutyl)benzyloxy]-3-methylchromen-4-one
Rattus norvegicus
-
-
0.009
2-[4-(4-fluorobutyl)benzylsulfanyl]-3-methylchromen-4-one
Rattus norvegicus
-
-
0.014
3-(thiophen-2-ylthio)-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)propan-1-one
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
-
0.00001
37-methoxyquinoxalinone
Bos taurus
-
IC50: 10 nM
0.000017
39-pyridopyrazinone
Bos taurus
-
IC50: 17 nM
0.027
4-(thiophen-2-yl)-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)butan-1-one
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
-
0.015
4-(thiophen-2-yl)-1-(4-(4-(trifluoromethyl)phenyl)piperidin-1-yl)butan-1-one
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
-
0.1
5-(N-ethyl)-N-isopropylamiloride
Escherichia coli
-
IC50 : 0.1 mM
0.0000037
5-fluoro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)-phenyl)quinolin-4(1H)-one
Plasmodium falciparum
pH 7.0, 25°C
0.006
5-phenyl-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)pentan-1-one
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
-
0.0000045
6-amino-4-(4-tert-butylphenethylamino)quinazoline
0.0000023
6-azido-N-[2-(4-tert-butylphenyl)ethyl]-6,7-dihydroquinazolin-4-amine
Bos taurus
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.07
benzamil
Escherichia coli
-
IC50: 0.07 mM
0.00000083
bullatacin
Bos taurus
-
IC50: 0.00000083 mM
0.25
dicyclohexylcarbodi-imide
Escherichia coli
-
90% inhibition, IC50: 0.25 mM
0.013
diphenylene iodonium
Agrobacterium tumefaciens
-
75% inhibition, IC50: 0.013 mM
0.09
fenazaquin
Rattus norvegicus
-
-
0.15
flutamide
Mus musculus
-
-
0.00017
Myxothiazol
Bos taurus
-
IC50: 170 nM
0.009
palmitate
Bos taurus
-
IC50: 0.009 mM, at 25°C and pH 8.0
0.0000013
Piericidin A
Bos taurus
-
IC50: 0.0000013 mM
0.045
polymyxin B1
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.057
polymyxin B2
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.008
pyridaben
Rattus norvegicus
-
-
0.00000085
squamocin M
Bos taurus
-
IC50: 0.00000085 mM
0.01 - 0.05
Zn2+
Bos taurus
-
pH-dependent potent inhibitor, IC50: 0.01-0.05 mM at pH 7.5, depending on the enzyme state, Zn2+ does not inhibit NADH oxidation or intramolecular electron transfer, so it probably inhibits either proton transfer to bound quinone or proton translocation.
0.052
[2-(4-butyl)benzylsulfanyl]-3-methylchromen-4-one
Rattus norvegicus
-
-
additional information
(1R,1'R)-1,1'-((2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyl)-bis-(6-(4-n-butylphenoxy)hexan-1-ol)
0.0000016
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyldiundecan-1-ol
Bos taurus
-
IC50: 1.6 nM
0.0000016
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyldiundecan-1-ol
Bos taurus
-
IC50: 0.0000016 mM
0.000009
(1R,1'S)-1,1'-(2R,5R)-tetrahydrofuran-2,5-diylditridecan-1-ol
Bos taurus
-
IC50: 9.0 nM
0.025
(1R,1'S)-1,1'-(2R,5R)-tetrahydrofuran-2,5-diylditridecan-1-ol
Bos taurus
-
IC50: 0.025 mM
0.0000045
6-amino-4-(4-tert-butylphenethylamino)quinazoline
Mycobacterium tuberculosis
-
pH and temperature not specified in the publication
0.0000045
6-amino-4-(4-tert-butylphenethylamino)quinazoline
Bos taurus
pH and temperature not specified in the publication
0.251
colistin
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.356
colistin
Acinetobacter baumannii
-
pH not specified in the publication, temperature not specified in the publication
0.376
colistin
Klebsiella pneumoniae
-
pH not specified in the publication, temperature not specified in the publication
0.05
Polymyxin B
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.167
Polymyxin B
Acinetobacter baumannii
-
pH not specified in the publication, temperature not specified in the publication
0.168
Polymyxin B
Klebsiella pneumoniae
-
pH not specified in the publication, temperature not specified in the publication
0.002
rotenone
Aquifex aeolicus
-
IC50: 0.002 mM
0.016
rotenone
Rattus norvegicus
-
-
additional information
(1R,1'R)-1,1'-((2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyl)-bis-(6-(4-n-butylphenoxy)hexan-1-ol)
Bos taurus
-
IC50: above 15 mM
additional information
additional information
Mycolicibacterium smegmatis
-
IC50 for polymyxin B is 0.0014 mg/ml, IC50 for nanaomycin A is 0.031 mg/ml
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0098
-
mutant enzyme E234Q, using ubiquinone-1 as substrate
0.04
-
mutant enzyme E36A, using deamino-NADH as electron donor
0.042
-
mutant enzyme E36Q, using deamino-NADH as electron donor
0.08
-
mutant enzyme R25A/R26A, using deamino-NADH as electron donor
0.149
-
mutant enzyme E72Q, using deamino-NADH as electron donor
0.15
-
mutant enzyme E234Q, using hexammineruthenium-(III)-chloride as substrate
0.151
-
mutant enzyme R25A, using deamino-NADH as electron donor
0.161
-
wild type enzyme, using ubiquinone-1 as substrate
0.163
-
mutant enzyme E228Q, using hexammineruthenium-(III)-chloride as substrate
0.175
-
mutant enzyme E234D, using ubiquinone-1 as substrate
0.176
-
mutant enzyme R25K, using deamino-NADH as electron donor
0.186
-
NADH-ubiquinone-0 oxidoreductase activity
0.211
-
mutant enzyme R209H, using NADH as substrate
0.213
-
mutant enzyme E228K, using hexammineruthenium-(III)-chloride as substrate
0.222
-
mutant enzyme R26A, using deamino-NADH as electron donor
0.229
-
mutant enzyme R209F, using hexammineruthenium-(III)-chloride as substrate
0.245
-
mutant enzyme D213E, using hexammineruthenium-(III)-chloride as substrate
0.249
-
mutant enzyme R209H, using hexammineruthenium-(III)-chloride as substrate
0.256
-
mutant enzyme R209F, using NADH as substrate
0.259
-
mutant enzyme V206E, using hexammineruthenium-(III)-chloride as substrate
0.265
-
mutant enzyme R209K, using hexammineruthenium-(III)-chloride as substrate
0.273
-
mutant enzyme E72A, using deamino-NADH as electron donor
0.305
-
mutant enzyme E228D, using hexammineruthenium-(III)-chloride as substrate
0.31
-
mutant enzyme H210F, using NADH as substrate
0.313
-
mutant enzyme V206E, using NADH as substrate
0.316
-
mutant enzyme H210T, using hexammineruthenium-(III)-chloride as substrate
0.32
-
mutant enzyme E228Q, using NADH as substrate
0.324
-
mutant enzyme D213E, using NADH as substrate
0.329
-
mutant enzyme H210F, using hexammineruthenium-(III)-chloride as substrate
0.341
-
mutant enzyme D213N, using NADH as substrate
0.348
-
mutant enzyme Y229H, using NADH as substrate
0.351
-
mutant enzyme G21V, using deamino-NADH as electron donor
0.354
-
mutant enzyme E216A, using hexammineruthenium-(III)-chloride as substrate
0.368
-
mutant enzyme D213N, using hexammineruthenium-(III)-chloride as substrate
0.424
-
mutant enzyme E228D, using NADH as substrate
0.442
-
mutant enzyme E216A, using NADH as substrate
0.514
-
mutant enzyme F15A, using deamino-NADH as electron donor
0.556
-
mutant enzyme R85K, using deamino-NADH as electron donor
0.564
-
mutant enzyme R85A, using deamino-NADH as electron donor
0.568
-
mutant enzyme R87A, using deamino-NADH as electron donor
0.57
-
in 50 mM MOPS containing 10 mM MgCl2 at pH 7.3, using 0.25 mM deamino-NADH as substrate
0.571
-
wild type enzyme, using deamino-NADH as electron donor
0.603
-
mutant enzyme R87K, using deamino-NADH as electron donor
0.63
-
wild type enzyme, using NADH as substrate
0.8
-
wild type enzyme, using hexammineruthenium-(III)-chloride as substrate
0.84
-
wild type enzyme, using hexamineruthenium(III)-chloride as substrate
1.144
-
wild type enzyme, using hexammineruthenium-(III)-chloride as substrate
1.17
60°C, pH 7.5, recombinant protein expressed in Escherichia coli, presence of FAD
1.2
-
NADH:duroquinone reductase activity
1.23
60°C, pH 7.5, recombinant protein expressed in Escherichia coli, presence of FAD
1.3
-
50°C, 0.02 mM ubiquinone-2 as substrate
1.34
-
mutant enzyme E234D, using hexammineruthenium-(III)-chloride as substrate
11.5
-
activity with ubiquinone-2
13.2
-
reduction of Coenzyme Q10
16.1
-
mutant enzyme R141M, NADH-dependent activity of complex 1 containing proteoliposomes using hexaammineruthenium-(III)-chloride as substrate
1671
-
reaction with ubiquinone-2
18.6
-
pH not specified in the publication, temperature not specified in the publication
195
-
NADH + ubiquinone-2, 60°C
2.2
-
membrane extract, using hexaammineruthenium-III-chloride as substrate
2.3
-
mutant enzyme R141M, NADH-dependent activity of complex 1 containing proteoliposomes using n-decylubiquinone as substrate
20
60°C, pH 7.5, recombinant protein expressed in Thermus thermopilus, presence of FAD
23
-
wild type enzyme, NADH-dependent activity of complex 1 containing proteoliposomes using hexaammineruthenium-(III)-chloride as substrate
273
-
after 6.2fold purification
35.91
-
ca. 20 h survival after seizures
36.28
-
acute phase of seizures
39.1
-
in 20 mM MOPS containing 50 mM KCl at pH 7.4, using hexamineruthenium(III)-chloride as substrate
4.1
-
in 20 mM MOPS containing 50 mM KCl at pH 7.4, using n-decylubiquinone as substrate
5.5
-
wild type enzyme, NADH-dependent activity of complex 1 containing proteoliposomes using n-decylubiquinone as substrate
6.77
pH 7.0, 30°C, N-terminally tagged protein
61.9
-
reaction with ubiquinone-6
64
-
NADH:hexamineruthenium(III)-chloride oxidoreductase activity
7.52
pH 7.0, 30°C, N-terminally tagged protein
90
-
after purification, using hexaammineruthenium-III-chloride as substrate
0.268
-
mutant enzyme H210T, using NADH as substrate
0.268
-
mutant enzyme R209K, using NADH as substrate
0.274
-
mutant enzyme E228K, using NADH as substrate
0.274
-
mutant enzyme Y229H, using hexammineruthenium-(III)-chloride as substrate
0.62
-
mutant enzyme R26K, using deamino-NADH as electron donor
0.62
-
mutant enzyme H129A, using hexamineruthenium(III)-chloride as substrate
10.3
-
NADH-ferricyanide oxidoreductase activity
10.3
-
reduction of K3Fe(CN)6
4.8
-
-
4.8
-
in 20 mM MOPS containing 50 mM KCl at pH 7.4, using ubiquinone-1 as substrate
additional information
-
-
additional information
-
-
additional information
-
NADH/ferricyanide oxidoreductase activity (measured as ferricyanide reduction) and NAD(P)H oxidase activity (measured as oxygen consumption) of cytoplasmic membranes from Escherichia coli recombinantly expressing the enzyme
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10.01
-
subunit NDUFA2, calculation from nucleotide sequence
10.04
-
subunit NDUFB6, calculation from nucleotide sequence
10.1
-
subunit NDUFA6, calculation from nucleotide sequence
10.15
-
subunit NDUFA6, calculation from nucleotide sequence
10.17
-
subunit NDUFA7, calculation from nucleotide sequence
10.3
-
subunit B17.2, calculation from nucleotide sequence
10.48
-
subunit NDUFA7, calculation from nucleotide sequence
3.67
-
subunit ND 6, calculation from nucleotide sequence
3.84
-
subunit ND 6, calculation from nucleotide sequence
4.17
-
subunit NDUFAB1, calculation from nucleotide sequence
4.44
-
subunit NDUFB2, calculation from nucleotide sequence
4.48
-
subunit NDUFB2, calculation from nucleotide sequence
4.71
-
subunit NDUFAB1, calculation from nucleotide sequence
4.92
-
subunit NDUFB8, calculation from nucleotide sequence
5.07
-
subunit NDUFV2, calculation from nucleotide sequence
5.13
-
subunit NDUFS8, calculation from nucleotide sequence
5.24
-
subunit NDUFS1, calculation from nucleotide sequence
5.26
-
subunit NDUFB8, calculation from nucleotide sequence
5.28
-
subunit NDUFS1, calculation from nucleotide sequence
5.31
-
subunit NDUFV2, calculation from nucleotide sequence
5.45
-
subunit NDUFS3, calculation from nucleotide sequence
5.55
-
subunit NDUFS3, calculation from nucleotide sequence
5.86
-
subunit NDUFS2, calculation from nucleotide sequence
5.95
-
subunit NDUFS2, calculation from nucleotide sequence
6.2
-
isoelectric focusing
6.25
-
subunit NDUFV3, calculation from nucleotide sequence
6.31
-
subunit NDUFB5, calculation from nucleotide sequence
6.39
-
subunit NDUFV3, calculation from nucleotide sequence
6.64
-
subunit NDUFS6, calculation from nucleotide sequence
6.84
-
subunit NDUFA5, calculation from nucleotide sequence
7.53
-
subunit NDUFV1, calculation from nucleotide sequence
7.57
-
subunit NDUFB10, calculation from nucleotide sequence
7.82
-
subunit NDUFA5, calculation from nucleotide sequence
7.92
-
subunit NDUFV1, calculation from nucleotide sequence
7.93
-
subunit NDUFS6, calculation from nucleotide sequence
8.03
-
subunit NDUFA3, calculation from nucleotide sequence
8.19
-
subunit NDUFB10, calculation from nucleotide sequence
8.29
-
subunit B14.7, calculation from nucleotide sequence
8.34
-
subunit NDUFC1, calculation from nucleotide sequence
8.35
-
subunit NDUFB7, calculation from nucleotide sequence
8.39
-
subunit NDUFA8, calculation from nucleotide sequence
8.69
-
subunit NDUFB7, calculation from nucleotide sequence
8.76
-
subunit NDUFA8, calculation from nucleotide sequence
9
-
subunit NDUFA3, calculation from nucleotide sequence
9.15
-
subunit ND 5, calculation from nucleotide sequence
9.34
-
subunit ND 5, calculation from nucleotide sequence
9.38
-
subunit NDUFC2, calculation from nucleotide sequence
9.41
-
subunit NDUFC2, calculation from nucleotide sequence
9.42
-
subunit ND 4, calculation from nucleotide sequence
9.47
-
subunit B16.6, calculation from nucleotide sequence
9.48
-
subunit NDUFA9, calculation from nucleotide sequence
9.49
-
subunit NDUFS4, calculation from nucleotide sequence
9.51
-
subunit NDUFA1, calculation from nucleotide sequence
9.64
-
subunit NDUFA9, calculation from nucleotide sequence
9.65
-
subunit NDUFS4, calculation from nucleotide sequence
9.75
-
subunit NDUFA2, calculation from nucleotide sequence
9.79
-
subunit NDUFB6, calculation from nucleotide sequence
9.89
-
subunit NDUFB4, calculation from nucleotide sequence
9.93
-
subunit ND 2, calculation from nucleotide sequence
4.5
-
subunit ND 3, calculation from nucleotide sequence
4.5
-
subunit ND 3, calculation from nucleotide sequence
4.6
-
subunit ESSS, calculation from nucleotide sequence
4.6
-
subunit ESSS, calculation from nucleotide sequence
5.1
-
subunit NDUFA1, calculation from nucleotide sequence
5.1
-
subunit NDUFS8, calculation from nucleotide sequence
5.43
-
subunit ND 4L, calculation from nucleotide sequence
5.43
-
subunit ND 4L, calculation from nucleotide sequence
5.96
-
subunit NDUFA10, calculation from nucleotide sequence
5.96
-
subunit NDUFA10, calculation from nucleotide sequence
6.42
-
subunit ND 1, calculation from nucleotide sequence
6.42
-
subunit NDUFB5, calculation from nucleotide sequence
6.42
-
subunit ND 1, calculation from nucleotide sequence
7.68
-
subunit NDUFB9, calculation from nucleotide sequence
7.68
-
subunit NDUFB9, calculation from nucleotide sequence
8.3
-
subunit B16.6, calculation from nucleotide sequence
8.3
-
subunit B14.7, calculation from nucleotide sequence
9.01
-
subunit NDUFB3, calculation from nucleotide sequence
9.01
-
subunit NDUFB3, calculation from nucleotide sequence
9.1
-
subunit NDUFS5, calculation from nucleotide sequence
9.1
-
subunit NDUFS5, calculation from nucleotide sequence
9.45
-
subunit NDUFB1, calculation from nucleotide sequence
9.45
-
subunit ND 4, calculation from nucleotide sequence
9.52
-
subunit B17.2, calculation from nucleotide sequence
9.52
-
subunit NDUFA4, calculation from nucleotide sequence
9.71
-
subunit NDUFS7, calculation from nucleotide sequence
9.71
-
subunit NDUFS7, calculation from nucleotide sequence
9.82
-
subunit ND 2, calculation from nucleotide sequence
9.82
-
subunit NDUFB4, calculation from nucleotide sequence
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evolution
-
bacterial Complex I is about half the size of the mitochondrial enzyme and is composed of only 13, in Escherichia coli, subunits representing a minimum functional version of the mitochondrial enzyme and performing the same function of coupling redox reaction to proton translocation. Prokaryotic Complex I is much more fragile than the eukaryotic mitochondrial enzyme
evolution
-
bacterial Complex I is about half the size of the mitochondrial enzyme and is composed of only 13, in Escherichia coli, subunits representing a minimum functional version of the mitochondrial enzyme and performing the same function of coupling redox reaction to proton translocation. Prokaryotic Complex I is much more fragile than the eukaryotic mitochondrial enzyme
evolution
-
bacterial Complex I is about half the size of the mitochondrial enzyme and is composed of only 13, in Escherichia coli, subunits representing a minimum functional version of the mitochondrial enzyme of eukaryotes and performing the same function of coupling redox reaction to proton translocation. Prokaryotic Complex I is much more fragile than the eukaryotic mitochondrial enzyme
evolution
-
complex I has been subject to a phenomenal increase in size that predates the diversification of extant eukaryotes, followed by very few lineage-specific additions/losses of subunits
evolution
-
the complex I subunits NuoL, NuoM and NuoN are homologous to two proteins, MrpA and MrpD, from one particular class of Na+/H+ antiporters. In many bacteria MrpA and MrpD are encoded by an operon comprising 6-7 conserved genes
malfunction
-
defects in complex I are the most frequent cause of human respiratory disorders. Substitution L158P does not lead to any respiratory enzyme defects when present in the heteroplasmic state in a patient with chronic progressive external ophthalmoplegia
malfunction
-
deletion of either mrpA or mrpD from the Bacillus subtilis chromosome resulted in a Na+ and pH sensitive growth phenotype. NuoL can rescue Bacillus subtilis DELTAmrpA, but improved the growth of Bacillus subtilis DELTAmrpD only slightly. NuoN can restore the wild type properties of Bacillus subtilis DELTAmrpD, but has no effect on the ?mrpA strain. Expression of NuoM does not result in any growth improvement under these conditions. This reveals that the complex I subunits NuoL, NuoM and NuoN also demonstrate functional specializations
malfunction
-
electron transfer and proton translocation activity of complex I variants lacking either NuoL or parts of the C-terminal domain, overview
malfunction
Chlamydomonas sp.
-
when present in the homoplasmic state in the alga, the mutation does not prevent assembly of the whole complex I, the NADH dehydrogenase activity of the peripheral arm of the complex is mildly affected. The NADH:duroquinone oxidoreductase activity is strongly reduced, suggesting that the substitution could affect binding of ubiquinone to the membrane domain. The membrane potential is not affected in mutant mitochondria. The in vitro defects correlate with a decrease in dark respiration and growth rate in vivo, phenotype, overview
malfunction
-
electron transfer and proton translocation activity of complex I variants lacking either NuoL or parts of the C-terminal domain, overview
-
physiological function
Vitis vinifera x Vitis vinifera
-
involved in aromatic amino acid metabolism
physiological function
-
involved in aromatic amino acid metabolism
physiological function
-
the NuoG subunit of the type I NADH dehydrogenase, NDH-1, is important in Mycobacterium tuberculosis-mediated inhibition of host macrophage apoptosis, the NDH-1 complex is important for NOX2 neutralization in host macrophages
physiological function
-
NDE2 is the main external dehydrogenase responsible for the oxidation of cytosolic NADH and NADPH under physiological conditions
physiological function
-
Ndi1p functionally interacts with the nematode respiratory chain and contributes to the formation of the mitochondrial membrane potential in vivo. Ndi1p expression results in significantly improved reproductive success, better survival under conditions of oxidative stress, fewer signs of premature aging, increased respiration rates and a complete restoration of the in vivo mitochondrial membrane potential in Caenorhabditis elegans nuo-1 mutants. However, Ndi1p is not able to fully replace complex I and cannot support larval development when complex I is missing
physiological function
-
Complex I catalyzes two-electron NADH oxidation and ubiquinone reduction coupled to the transmembrane translocation of 3 or 4 H+ from negatively charged side (N-side, cytoplasm or mitochondrial matrix) to positively charged side (P-side, periplasm or mitochondrial intermembrane space) of the membrane per 2 electrons
physiological function
-
Complex I catalyzes two-electron NADH oxidation and ubiquinone reduction coupled to the transmembrane translocation of 3 or 4H+ from negatively charged side (N-side, cytoplasm or mitochondrial matrix) to positively charged side (P-side, periplasm or mitochondrial intermembrane space) of the membrane per 2 electrons
physiological function
-
Complex I catalyzes two-electron NADH oxidation and ubiquinone reduction coupled to the transmembrane translocation of 3 or 4H+ from negatively charged side (N-side, cytoplasm or mitochondrial matrix) to positively charged side (P-side, periplasm or mitochondrial intermembrane space) of the membrane per 2 electrons
physiological function
-
complex I is one of the respiratory complexes that generate the proton-motive force required for the synthesis of ATP in mitochondria. The electron transfer from NADH to ubiquinone through protein-bound prosthetic groups, which is coupled to the translocation of protons across the inner mitochondrial membrane
physiological function
-
in mitochondria, complex I (NADH:ubiquinone oxidoreductase) uses the redox potential energy from NADH oxidation by ubiquinone to transport protons across the inner membrane, contributing to the proton-motive force
physiological function
-
MrpA transports Na+ whereas MrpD transports H+ in opposite directions, resulting in antiporter activity, besides one Na+ channel, NuoL, and two H+ channels, NuoM and NuoN, are present.
physiological function
-
NADH:ubiquinone oxidoreductase (complex I) is a complicated respiratory enzyme that conserves the energy from NADH oxidation, coupled to ubiquinone reduction, as a proton motive force across the mitochondrial inner membrane. During catalysis, NADH oxidation by a flavin mononucleotide is followed by electron transfer to a chain of iron-sulfur clusters. Alternatively, the flavin may be reoxidized by hydrophilic electron acceptors, by artificial electron acceptors in kinetic studies, or by oxygen and redox-cycling molecules to produce reactive oxygen species
physiological function
-
NADH:ubiquinone oxidoreductase (complex I) pumps protons across the membrane using downhill redox energy
physiological function
-
respiratory complex I couples the transfer of electrons from NADH to ubiquinone with a translocation of protons across the membrane
physiological function
The enzyme's major function is the transfer of two electrons from NADH (matrix side) to ubiquinone (inner mitochondrial membrane), biochemical function and physiological role of diverse plant specific complex I subunits, overview
physiological function
-
the flavin mononucleotide in complex I catalyzes NADH oxidation, O2 reduction to superoxide, and the reduction of several artificial electron acceptors
physiological function
-
the respiratory complex I couples the electron transfer from NADH to ubiquinone with a translocation of protons across the membrane
physiological function
after reconstituting isolated AIFM1 into bacterial or mitochondrial membranes, N-terminally tagged AIFM1 displays substantial NADH:O2 activity and supports NADH-linked proton pumping activities in the host membranes. Overexpressing N-terminally tagged AIFM1 and AIF-homologous mitochondrion-associated inducer of death AMID enhances the growth of a double knock-out Escherichia coli strain lacking complex I and NDH-2. C-terminally tagged AIFM1 and NADH-binding site mutants of N-terminally tagged AIFM1 and AMID fail to show both NADH:O2 activity and the growth-enhancing effect
physiological function
after reconstituting isolated AIFM2 into bacterial or mitochondrial membranes, N-terminally tagged AIFM2 displays substantial NADH:O2 activity and supports NADH-linked proton pumping activities in the host membranes. Overexpressing N-terminally tagged AIFM1 and AIFM2 enhances the growth of a double knock-out Escherichia coli strain lacking complex I and NDH-2. NADH-binding site mutants of N-terminally tagged AIFM1 and AIFM2 fail to show both NADH:O2 activity and the growth-enhancing effect
physiological function
-
complex I is invovled in in lipopolysaccharide action in macrophages
physiological function
improper splicing of Nad1 transcripts leads to the absence of mitochondrial complex I and alteration of the nuclear transcriptome
physiological function
-
inducible knockdown of NDH2 has a modest growth effect in bloodstream forms, but NDH2 null mutants, as well as inducible knockdowns in a complex I deficient back-ground, show a greater reduction in growth. Loss of NDH2 leads to reduced levels of acetate, which is required for several essential pathways in bloodstream form Trypanosoma brucei
physiological function
protein NrcN functions independently of other components of the putative Nrc complex
physiological function
rerouting electrons through the NDA2 catalytic hub in response to photoautotrophic N deprivation sustains cell viability while promoting the dissipation of excess excitation energy through quenching and chlororespiratory processes. The type II NADPH dehydrogenase is key to acclimation of cells to N deprivation. NDA2 drives cyclic electron flow, chlororespiration, and the generation of an H+ gradient across the thylakoid membranes. N deprivation elicits a doubling of the rate of NDA2-dependent cyclic electron flow, with little contribution from PGR5/PGRL1-dependent cyclic electron flow. Stimulation of NDA2-dependent chlororespiration affords additional relief from the elevated reduction state associated with N deprivation through plastid terminal oxidase-dependent water synthesis
physiological function
-
subunit NuoL is involved in the high efficiency pumping mechanism in complex I
physiological function
O67333; O67334; O67335; O66841; O66748; O67336; O67338; O67339; O67340; O67341; O67342, O67392; O67334; O66826; O66842; O66841; O66748; O67384; O67386; O67338; O67339; O67027; O67390; O67391 presence of two different complex I isoforms. Isoform NQOR1 consists of subunits NuoA2, NuoB, NuoD2, NuoE, NuoF, NuoG, NuoI1, NuoH1, NuoJ1, NuoK1,NuoL1, NuoM1 and NuoN1, with an entire mass of 504.17 kDa
physiological function
O67333; O67334; O67335; O66841; O66748; O67336; O67338; O67339; O67340; O67341; O67342, O67392; O67334; O66826; O66842; O66841; O66748; O67384; O67386; O67338; O67339; O67027; O67390; O67391 presence of two different complex I isoforms. Isoform NQOR2 comprises subunits NuoA1, NuoB, NuoD1, NuoE, NuoF, NuoG, NuoH2, NuoI2, NuoJ1, NuoK1, NuoL2, NuoM2 and NuoN2, with a total mass of 523.99 kDa
physiological function
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protein NrcN functions independently of other components of the putative Nrc complex
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physiological function
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respiratory complex I couples the transfer of electrons from NADH to ubiquinone with a translocation of protons across the membrane
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physiological function
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improper splicing of Nad1 transcripts leads to the absence of mitochondrial complex I and alteration of the nuclear transcriptome
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physiological function
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the NuoG subunit of the type I NADH dehydrogenase, NDH-1, is important in Mycobacterium tuberculosis-mediated inhibition of host macrophage apoptosis, the NDH-1 complex is important for NOX2 neutralization in host macrophages
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physiological function
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Ndi1p functionally interacts with the nematode respiratory chain and contributes to the formation of the mitochondrial membrane potential in vivo. Ndi1p expression results in significantly improved reproductive success, better survival under conditions of oxidative stress, fewer signs of premature aging, increased respiration rates and a complete restoration of the in vivo mitochondrial membrane potential in Caenorhabditis elegans nuo-1 mutants. However, Ndi1p is not able to fully replace complex I and cannot support larval development when complex I is missing
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additional information
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mechanism of NADH oxidation by complex I, the adenosine moiety of NADH is crucial for binding, overview
additional information
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NuoA is a small membrane spanning subunit of respiratory chain NADH:quinone oxidoreductase (complex I). Unlike the other complex I core protein subunits, the NuoA protein has no known homologue in other enzyme systems
additional information
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potential energy profile for the Complex I substrates and cofactors, overview
additional information
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potential energy profile for the Complex I substrates and cofactors, overview
additional information
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potential energy profile for the Complex I substrates and cofactors, overview. Redox potentials of mitochondrial respiratory complexes, overview. Two domains, hydrophilic and hydrophobic, constitute Complex I. The hydrophilic domain of Complex I contains noncovalently bound FMN and 8-9 FeS clusters, 8 of which are organized as a continuous eT chain connecting FMN and a UQ binding site. One or two UQ-binding sites are located at the interface between the hydrophilic and membrane Complex I domains or in the membrane domain close to the interface area. The hydrophilic domain is composed of 6 or 7 core subunits and protrudes to cytoplasm or mitochondrial matrix. The substrate binding site is located in the open cleft on the surface of the protein. The conserved residues aligning this solvent-accessible cavity form an unusual Rossmann fold, which provides tight packing of the substrate, ensures the planar condensed system of the nicotinamide and the FMN isoalloxazine rings and therefore determines high affinity to NADH, substrate specificity and high rate of hydride transfer to FMN. Structure-function modeling, different mechanistic models, detailed overview
additional information
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the accessory subunits of eukaryotic complex I bear an allosteric ATP binding site
additional information
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the accessory subunits of eukaryotic complex I bear an allosteric ATP binding site
additional information
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the accessory subunits of eukaryotic complex I bear an allosteric ATP binding site
additional information
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the complex consists of a peripheral arm catalyzing the electron transfer reaction and a membrane arm involved in proton translocation. The energy released by the redox reaction is transmitted to the membrane arm via a conformational change in the horizontal helix. The helix corresponds to the C-terminal part of the most distal subunit NuoL. The C-terminal domain of NuoL is essential for the translocation of 2H+/2e-
additional information
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the deactive state of complex I is formed during hypoxia, when respiratory chain turnover is slowed, and may contribute to determining the outcome of ischemia-reperfusion injury
additional information
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the complex consists of a peripheral arm catalyzing the electron transfer reaction and a membrane arm involved in proton translocation. The energy released by the redox reaction is transmitted to the membrane arm via a conformational change in the horizontal helix. The helix corresponds to the C-terminal part of the most distal subunit NuoL. The C-terminal domain of NuoL is essential for the translocation of 2H+/2e-
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10124
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
10130
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
10598
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
10777
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
10845
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
10916
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
11267
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
11482
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
11690
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
12500
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
12576
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
12648
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
12700
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
13071
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
13360
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
13412
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
14322
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
14359
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
15064
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
15081
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
15215
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
15224
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
15283
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
15356
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
15515
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
15638
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
16331
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
16568
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
16858
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
16870
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
17000
-
12 * 17000, SDS-PAGE
18816
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
18851
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
19992
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
200000
-
non-denaturing PAGE
20248
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
20280
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
20406
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
20442
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
20859
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
21024
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
21396
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
21966
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
21984
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
23847
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
23933
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
24000
-
2 * 24000, SDS-PAGE
25000
-
SDS-PAGE, NuoE subunit
250000
-
soluble subcomplex
26452
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
26479
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
300000
-
membrane subcomplex
33000
-
2 * 33000, SDS-PAGE
35651
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
36000
-
1 * 36000, SDS-PAGE
36133
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
36843
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
36947
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
37000
-
x * 37000, SDS-PAGE
38653
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
38810
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
38872
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
47000
-
1 * 47000, SDS-PAGE
48583
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
48626
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
49230
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
49244
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
51783
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
52000
-
SDS-PAGE, NuoF subunit
520000
-
above, gel filtration
57000
-
x * 57000, SDS-PAGE
570000
-
about, recombinant His-tagged complex I, gel filtration
5753
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
610000
-
calculation from sedimentation data
64660
-
calculated from amino acid sequence
6996
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
76860
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
77183
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
8028
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
8139
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
8148
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
8238
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
8454
-
x * 8148 (subunit NDUFA1) + x * 10845 (subunit NDUFA2) + x * 11482 (subunit NDUFA3) + x * 13412 (subunit NDUFA5) + x * 15224 (subunit NDUFA6) + x * 12500 (subunit NDUFA7) + x * 21966 (subunit NDUFA8) + x * 38872 (subunit NDUFA9) + x * 36843 (subunit NDUFA10) + x * 10124 (subunit NDUFAB1) + x * 8454 (subunit NDUFB2) + x * 11267 (subunit NDUFB3) + x * 15064 (subunit NDUFB4) + x * 16870 (subunit NDUFB5) + x * 15638 (subunit NDUFB6) + x * 16568 (subunit NDUFB7) + x * 18851 (subunit NDUFB8) + x * 21396 (subunit NDUFB9) + x * 20859 (subunit NDUFB10) + x * 14359 (subunit NDUFC2) + x * 76860 (subunit NDUFS1) + x * 49244 (subunit NDUFS2) + x * 26452 (subunit NDUFS3) + x * 15215 (subunit NDUFS4) + x * 12700 (subunit NDUFS5) + x * 10598 (subunit NDUFS6) + x * 20248 (subunit NDUFS7) + x * 20406 (subunit NDUFS8) + x * 48583 (subunit NDUFV1) + x * 23933 (subunit NDUFV2) + x * 8238 (subunit NDUFV3) + x * 36133 (subunit ND 1) + x * 38653 (subunit ND 2) + x * 13071 (subunit ND3) + x * 51783 (subunit N
8491
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
87000
-
disc gel electrophoresis
9327
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
9331
-
x * 8139 (subunit NDUFA1) + x * 10916 (subunit NDUFA2) + x * 9331 (subunit NDUFA3) + x * 9327 (subunit NDUFA4) + x * 13360 (subunit NDUFA5) + x * 15283 (subunit NDUFA6) + x * 12576 (subunit NDUFA7) + x * 19992 (subunit NDUFA8) + x * 38810 (subunit NDUFA9) + x * 36947 (subunit NDUFA10) + x * 10130 (subunit NDUFAB1) + x * 6996 (subunit NDUFB1) + x * 8491 (subunit NDUFB2) + x * 11690 (subunit NDUFB3) + x * 15081 (subunit NDUFB4) + x * 16858 (subunit NDUFB5) + x * 15515 (subunit NDUFB6) + x * 16331 (subunit NDUFB7) + x * 18816 (subunit NDUFB8) + x * 21984 (subunit NDUFB9) + x * 21024 (subunit NDUFB10) + x * 5753 (subunit NDUFC1) + x * 14322 (subunit NDUFC2) + x * 77183 (subunit NDUFS1) + x * 49230 (subunit NDUFS2) + x * 26479 (subunit NDUFS3) + x * 15356 (subunit NDUFS4) + x * 12648 (subunit NDUFS5) + x * 10777 (subunit NDUFS6) + x * 20280 (subunit NDUFS7) + x * 20442 (subunit NDUFS8) + x * 48626 (subunit NDUFV1) + x * 23847 (subunit NDUFV2) + x * 8028 (subunit NDUFV3) + x * 35651 (subuni
950000
-
whole wild type enzyme, SDS-PAGE
46000
-
subunit NdhH
46000
-
1 * 46000, SDS-PAGE
50000
-
gel filtration
50000
-
calculated from sequence of cDNA
50000
-
2 * 50000, SDS-PAGE
51000
-
SDS-PAGE
51000
-
nuo-I subunit of wild type enzyme, SDS-PAGE
53000
-
SDS-PAGE
53000
-
x * 53000, SDS-PAGE
55000
-
SDS-PAGE
55000
-
x * 55000, SDS-PAGE
550000
-
sucrose density gradient centrifugation
550000
-
whole enzyme consisting of membrane and soluble subcomplex, SDS-PAGE
700000
-
about, sucrose density gradient centrifugation
700000
-
about, sucrose density gradient centrifugation
980000
-
-
additional information
-
several molecular mass forms of the purified complex exist
additional information
-
the enzyme exists in two kinetically and structurally distinct slowly interconvertible forms, active form A and de-activated form D. Continous slow cycling between form A and form D occurs during the steady-state operation of complex I in the mitochondria
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A352V
-
mutation in the 51 kDa subunit, shows mildly decreased NADH-dependent respiration and lactic acidosis
A443F
-
mutation in the 51 kDa subunit, shows decreased NADH-dependent respiration and lactic acidosis
T434M
-
mutation in the 51 kDa subunit, shows decreased NADH-dependent respiration and lactic acidosis
L158P
Chlamydomonas sp.
-
site-directed mutagenesis, introducetion of a Leu157Pro substitution into the Chlamydomonas ND4 subunit of complex I in two recipient strains by biolistic transformation
S2A
-
mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity
S2A/S8A
-
double mutant of phosphorylated subunit ESSS, mutant protein causes a complete failure to assemble
S2E
-
mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity
S30A
-
mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity
S30E
-
mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity
S55A
-
mutant of phosphorylated subunit MWFE, functional complex I can be assembled, mutant protein is expressed at a lower level compared to the wild-type protein
S55D
-
mutant of phosphorylated subunit MWFE, assembly of complex I is completely blocked
S55E
-
mutant of phosphorylated subunit MWFE, assembly of complex I is completely blocked
S55Q
-
mutant of phosphorylated subunit MWFE, assembly of complex I is completely blocked
S8A
-
mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity
S8E
-
mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity
T21A
-
mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity
T21E
-
mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity
D115N
-
45% of deamino-NADH oxidase activity of the wild type enzyme
D146N
-
59% of deamino-NADH oxidase activity of the wild type enzyme, one fourth reduced complex 1 content
D152N
-
59% of deamino-NADH oxidase activity of the wild type enzyme, one third reduced complex 1 content
D178N
-
mutant of subunit NuoL, about 80% of electron transfer activity of wild-type
D303A
-
mutant of subunit NuoL, about 60% of electron transfer activity of wild-type
D3400N
-
mutant of subunit NuoL, about 35% of electron transfer activity of wild-type
D400A
-
mutant of subunit NuoL, about 80% of electron transfer activity of wild-type
D400E
-
mutant of subunit NuoL, about 50% of electron transfer activity of wild-type
D77E
-
54% of deamino-NADH oxidase activity of the wild type enzyme
D77N
-
completely abolished electron transfer activity, 12% of deamino-NADH oxidase activity of the wild type enzyme
D94E
-
83% of deamino-NADH oxidase activity of the wild type enzyme
D94N
-
completely abolished electron transfer activity, 12% of deamino-NADH oxidase activity of the wild type enzyme
E119Q
-
88% of deamino-NADH oxidase activity of the wild type enzyme
E144A
-
mutation in subunit NuoM, quinone reductase activity is lost
E144Q
-
mutant of subunit NuoL, about 10% of electron transfer activity of wild-type
E163Q
-
76% of deamino-NADH oxidase activity of the wild type enzyme, one third reduced complex 1 content
E183D
-
site-directed mutagenesis, the mutant shows a 2fold increase in NADH/ferricyanide oxidoreductase activity and a 5fold increase in NADPHoxidase activity compared to the wild-type enzyme
E183H
-
site-directed mutagenesis, the mutant shows a 2fold increase in NADH/ferricyanide oxidoreductase activity and a 2fold increase in NADPHoxidase activitycompared to the wild-type enzyme
E183N
-
site-directed mutagenesis, the mutant shows a 2fold increase in NADH/ferricyanide oxidoreductase activity and a 2fold increase in NADPHoxidase activitycompared to the wild-type enzyme
E183Q
-
site-directed mutagenesis, the mutant shows a similar NADH/ferricyanide oxidoreductase activity and a 2fold increase NADPHoxidase activity compared to the wild-type enzyme
E36A
-
almost no NDH-1 activity
E36Q
-
almost no NDH-1 activity
E67D
-
78% of deamino-NADH oxidase activity of the wild type enzyme
E67Q
-
completely abolished electron transfer activity, one fourth reduced complex 1 content, 10% of deamino-NADH oxidase activity of the wild type enzyme
E72A
-
NDH-1 activity similar to wild type enzyme
E72Q
-
NDH-1 activity similar to wild type enzyme
F15A
-
NDH-1 activity similar to wild type enzyme
G21V
-
reduced NDH-1 activity
H101A
-
the NADH dehydrogenase subcomplex (NuoEFG subcomplex) in the cluster N5 mutant is unstable and dissociates from complex I. Recovery of these mutant NuoCDEFG subcomplexes by expressing the His-tagged NuoCD subunit, which has a high affinity to NuoG. At temperatures around -270°C no cluster N5 signals are found in the cluster N5 mutant
H101A/C114A
-
the NADH dehydrogenase subcomplex (NuoEFG subcomplex) in the cluster N5 mutant is unstable and dissociates from complex I. Recovery of these mutant NuoCDEFG subcomplexes by expressing the His-tagged NuoCD subunit, which has a high affinity to NuoG. At temperatures around -270°C no cluster N5 signals are found in the cluster N5 mutant
H101C
-
the NADH dehydrogenase subcomplex (NuoEFG subcomplex) in the cluster N5 mutant is unstable and dissociates from complex I. Recovery of these mutant NuoCDEFG subcomplexes by expressing the His-tagged NuoCD subunit, which has a high affinity to NuoG. At temperatures around -270°C no cluster N5 signals are found in the cluster N5 mutant
H334Q
-
mutant of subunit NuoL, about 50% of electron transfer activity of wild-type
K234A
-
mutation in subunit NuoM, quinone reductase activity is lost
K234R
-
mutation in subunit NuoM, quinone reductase activity is lost
R25A
-
reduced NDH-1 activity
R25A/R26A
-
strongly reduced NDH-1 activity
R25K
-
reduced NDH-1 activity
R26A
-
reduced NDH-1 activity
R26K
-
NDH-1 activity similar to wild type enzyme
R85A
-
NDH-1 activity similar to wild type enzyme
R85K
-
NDH-1 activity similar to wild type enzyme
R87A
-
NDH-1 activity similar to wild type enzyme
R87K
-
NDH-1 activity similar to wild type enzyme
W221A
-
mutant is used as a control subcomplex carrying wild-type clusters. At temperatures around -270°C a cluster N5 signals is detected in the control
Y229H
-
30% lower activity than wild type enzyme
D146N
-
59% of deamino-NADH oxidase activity of the wild type enzyme, one fourth reduced complex 1 content
-
D152N
-
59% of deamino-NADH oxidase activity of the wild type enzyme, one third reduced complex 1 content
-
D77N
-
completely abolished electron transfer activity, 12% of deamino-NADH oxidase activity of the wild type enzyme
-
E163Q
-
76% of deamino-NADH oxidase activity of the wild type enzyme, one third reduced complex 1 content
-
E67Q
-
completely abolished electron transfer activity, one fourth reduced complex 1 content, 10% of deamino-NADH oxidase activity of the wild type enzyme
-
E214K
-
inactive mutant
-
E216A
-
reduced activity
-
H210F
-
reduced activity
-
V206E
-
reduced activity
-
Y229H
-
30% lower activity than wild type enzyme
-
E234D
-
mutant with slightly reduced activity compared to the wild type enzyme
E234Q
-
mutant with strongly reduced activity compared to the wild type enzyme
H92R
T1KH75; A0A1D8X822
mutation in PSSt subunit, isolated in strains resistant to mitochondrial electron transport inhibitors such as pyridaben, tebufenpyrad and fenpyroximate. Mutation is involved in resistance
E107A
-
mutation in the 49000 Da subunit, no effect on complex I contant, mutant enzyme displays no deamino-nicotinamide-adeninedinucleotide:N-decylubiquinone activity
F87L
-
mutation in the 49000 Da subunit, no effect on complex I content, deamino-nicotinamide-adeninedinucleotide:N-decylubiquinone activity is reduced to aboput 60% of the parental strain value. The KM-value for n-decylubiquinone and the I50 value for rotenone are noemal
H129A
-
fully assembled but destabilized enzyme, without deamino-NADH:ubiquinone oxidoreductase activity
P232Q
-
mutation in thge 49000 Da subunit. Complex I assembly is severly impaired in this mutant. Deamino-nicotinamide-adeninedinucleotide:N-decylubiquinone activity is less than 20% of the normal value
R141M
-
reduced activity compared to wild type enzyme
R199W
-
mutation in the 30000 Da subunit, no significant alterations in complex I content or activity can be abserved in isolated mitochondrial membranes
R231E
-
mutation in the 49000 Da subunit of the complex, mutation has no effect on complex I content. Its deamino-nicotinamide-adeninedinucleotide:N-decylubiquinone activity is slightly reduced and its Km-value is somewhat elevated
R231Q
-
mutation in the 49000 Da subunit of the complex, no difference to wild-type enzyme in activity and stability
S416A
-
mutation in the 49000 Da subunit of the complex, mutation has no effect on complex I content. Its deamino-nicotinamide-adeninedinucleotide:N-decylubiquinone activity is slightly reduced. KM-value and I50 value for rotenone are both significantly higher than in the parental strain
S416P
-
mutation in the 49000 Da subunit of the complex, no difference to wild-type enzyme in activity and stability
T157I
-
mutation in the 30000 Da subunit, no significant alterations in complex I content or activity can be abserved in isolated mitochondrial membranes
E144D
-
mutation in subunit NuoM, mutant has wild type sensitivity to rolliniastatin and complete proton-pumping efficiency of complex I
E144D
-
mutation in subunit NuoM, quinone reductase activity is unchanged
K265A
-
mutation in subunit NuoM, mutant has wild type sensitivity to rolliniastatin and complete proton-pumping efficiency of complex I
K265A
-
mutation in subunit NuoM, quinone reductase activity is decreased
W243A
-
mutation in subunit NuoM, mutant has wild type sensitivity to rolliniastatin and complete proton-pumping efficiency of complex I
W243A
-
mutation in subunit NuoM, quinone reductase activity is decreased
additional information
-
construction of mrpA or mrpD deletion mutant strains, the deletion strains can be complemented in trans by their respective Mrp protein, but expression of MrpA in the Bacillus subtilis DELTAmrpD strain and vice versa does not improve growth at pH 7.4, mutant strains growth phenotypes, overview
additional information
-
deletion of the nuoN gene results in complete loss of activity
additional information
-
cluster N5 knock-out (DELTAN5) mutant: the NADH dehydrogenase subcomplex (NuoEFG subcomplex) in the cluster N5 mutant is unstable and dissociates from complex I. The data confirm that, cluster N5 has a unique coordination with His(Cys)3 ligands in subunit NuoG. Recovery of these mutant NuoCDEFG subcomplexes by expressing the His-tagged NuoCD subunit, which has a high affinity to NuoG. At temperatures around -270°C no cluster N5 signals are found in the cluster N5 mutant
additional information
-
deletion of any of the nuo-genes results in a loss of complex I activity in the membrane, the assembly of subunits is examined
additional information
-
construction of NuoL variants Y544Stop and W592Stop, that contain a stop codon leading to truncations in themiddle and at the end of the horizontal helix. The W592Stop variant is missing the C-terminal TM helix and the Y544Stop variant is missing this helix and approximately half of the amphipathic helix. Proton translocation by the mutant W592Stop variant and the Y544Stop variant after reconstitution in proteoliposomes, overview
additional information
-
construction of several variants with mutations at position 183 exhibiting up to 200fold enhanced catalytic efficiency with NADPH
additional information
-
construction of NuoL variants Y544Stop and W592Stop, that contain a stop codon leading to truncations in themiddle and at the end of the horizontal helix. The W592Stop variant is missing the C-terminal TM helix and the Y544Stop variant is missing this helix and approximately half of the amphipathic helix. Proton translocation by the mutant W592Stop variant and the Y544Stop variant after reconstitution in proteoliposomes, overview
-
additional information
-
mutation in the first intron of the NDUFS7 gene (c.17-1167 C > G), creates a strong donor splice site resulting in the generation of a cryptic exon, shows marked decrease of fully assembled complex I
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