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Disease on EC 7.2.1.3 - ascorbate ferrireductase (transmembrane)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Overexpression of cellular iron import proteins is associated with malignant progression of esophageal adenocarcinoma.
Anemia
Altered expression of intestinal duodenal cytochrome b and divalent metal transporter 1 might be associated with cardio-renal anemia syndrome.
Fermented Goat's Milk Consumption Improves Duodenal Expression of Iron Homeostasis Genes during Anemia Recovery.
Immunolocalization of duodenal cytochrome B: a relationship with circulating markers of iron status.
Anemia, Hypochromic
CIPK23 is involved in iron acquisition of Arabidopsis by affecting ferric chelate reductase activity.
Overexpression of AtFRO6 in transgenic tobacco enhances ferric chelate reductase activity in leaves and increases tolerance to iron-deficiency chlorosis.
Anemia, Sideroblastic
Recent advances in disorders of iron metabolism: mutations, mechanisms and modifiers.
ascorbate ferrireductase (transmembrane) deficiency
Congenital absence of norepinephrine due to CYB561 mutations.
Asthma
Genome-wide association study identifies TNFSF15 associated with childhood asthma.
Brain Diseases
Clonic seizures, continuous spikes-and-waves during slow sleep, choreoathetosis and response to sulthiame in a child with FRRS1L encephalopathy.
Loss of Frrs1l disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities.
Breast Neoplasms
DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms.
Carcinoma
Expression profiling of adrenocortical neoplasms suggests a molecular signature of malignancy.
Celiac Disease
Iron Transporter Protein Expressions in Children with Celiac Disease.
Colorectal Neoplasms
A novel test for gene-ancestry interactions in genome-wide association data.
Duodenal cytochrome b (Cybrd1) ferric reductase functional studies in cells.
Fatty Liver
Association of mRNA expression of iron metabolism-associated genes and progression of non-alcoholic steatohepatitis in rats.
Friedreich Ataxia
Recent advances in disorders of iron metabolism: mutations, mechanisms and modifiers.
Glioblastoma
Highly Expressed CYBRD1 Associated with Glioma Recurrence Regulates the Immune Response of Glioma Cells to Interferon.
Mouse cytochrome b561: cDNA cloning and expression in rat brain, mouse embryos, and human glioma cell lines.
Glioma
Highly Expressed CYBRD1 Associated with Glioma Recurrence Regulates the Immune Response of Glioma Cells to Interferon.
Mouse cytochrome b561: cDNA cloning and expression in rat brain, mouse embryos, and human glioma cell lines.
Hemochromatosis
A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis.
Analysis of genes implicated in iron regulation in individuals presenting with primary iron overload.
Analysis of polymorphism and hepatic expression of duodenal cytochrome b in chronic hepatitis C.
Duodenal cytochrome b (Cybrd1) ferric reductase functional studies in cells.
Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis.
Duodenal Dcytb and hephaestin mRNA expression are not significantly modulated by variations in body iron homeostasis.
Duodenal expression of iron transport molecules in untreated haemochromatosis subjects.
Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis.
Hepatitis C, Chronic
Analysis of polymorphism and hepatic expression of duodenal cytochrome b in chronic hepatitis C.
Hypotension, Orthostatic
Congenital absence of norepinephrine due to CYB561 mutations.
Mutations in CYB561 Causing a Novel Orthostatic Hypotension Syndrome.
Iron Deficiencies
CIPK23 is involved in iron acquisition of Arabidopsis by affecting ferric chelate reductase activity.
Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice.
Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess.
Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis.
Duodenal Dcytb and hephaestin mRNA expression are not significantly modulated by variations in body iron homeostasis.
Duodenal Reductase Activity and Spleen Iron Stores Are Reduced and Erythropoiesis Is Abnormal in Dcytb Knockout Mice Exposed to Hypoxic Conditions.
FIT interacts with AtbHLH38 and AtbHLH39 in regulating iron uptake gene expression for iron homeostasis in Arabidopsis.
Gene expression profiling of Hfe-/- liver and duodenum in mouse strains with differing susceptibilities to iron loading: identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers.
High-fat diet causes iron deficiency via hepcidin-independent reduction of duodenal iron absorption.
Immunolocalization of duodenal cytochrome B: a relationship with circulating markers of iron status.
Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency.
Microbial siderophores exert a subtle role in Arabidopsis during infection by manipulating the immune response and the iron status.
Molecular and functional roles of duodenal cytochrome B (Dcytb) in iron metabolism.
Mutational reconstructed ferric chelate reductase confers enhanced tolerance in rice to iron deficiency in calcareous soil.
Nonclinical Characterization of the Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat, a Novel Treatment of Anemia of Chronic Kidney Disease.
Overexpression of AtFRO6 in transgenic tobacco enhances ferric chelate reductase activity in leaves and increases tolerance to iron-deficiency chlorosis.
Overexpression of the FRO2 ferric chelate reductase confers tolerance to growth on low iron and uncovers posttranscriptional control.
Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis.
Responses to iron deficiency in Arabidopsis thaliana: the Turbo iron reductase does not depend on the formation of root hairs and transfer cells.
The molecular circuitry regulating the switch between iron deficiency and overload in mice.
[Mutational reconstructed ferric chelate reductase confers enhanced tolerance in rice to iron deficiency in calcareous soil]
Iron Overload
Analysis of genes implicated in iron regulation in individuals presenting with primary iron overload.
Analysis of polymorphism and hepatic expression of duodenal cytochrome b in chronic hepatitis C.
Effect of lipopolysaccharide and bleeding on the expression of intestinal proteins involved in iron and haem transport.
Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin.
The molecular circuitry regulating the switch between iron deficiency and overload in mice.
Lymphoma, B-Cell
Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membrane.
Neoplasm Metastasis
DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms.
Neoplasms
DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms.
Dihydrolipoic acid reduces cytochrome b561 proteins.
Electron Transfer Reactions of Candidate Tumor Suppressor 101F6 Protein, a Cytochrome b561 Homologue, with Ascorbate and Monodehydroascorbate Radical.
Elevated expression of the cytochrome b561, a neuroendocrine vesicle protein, in castration resistant prostate tumors.
Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membrane.
Highly Expressed CYBRD1 Associated with Glioma Recurrence Regulates the Immune Response of Glioma Cells to Interferon.
Identification of potential genes in upper tract urothelial carcinoma using next-generation sequencing with bioinformatics and in vitro analyses.
Overexpression of the natural antisense hypoxia-inducible factor-1alpha transcript is associated with malignant phaeochromocytoma/paraganglioma.
Spectral characterization of the recombinant mouse tumor suppressor 101F6 protein.
Porphyria Cutanea Tarda
Iron homeostasis in porphyria cutanea tarda: mutation analysis of promoter regions of CP, CYBRD1, HAMP and SLC40A1.
Porphyrias
Iron homeostasis in porphyria cutanea tarda: mutation analysis of promoter regions of CP, CYBRD1, HAMP and SLC40A1.
Prostatic Neoplasms
Elevated expression of the cytochrome b561, a neuroendocrine vesicle protein, in castration resistant prostate tumors.
Urinary Bladder Neoplasms
Identification of potential genes in upper tract urothelial carcinoma using next-generation sequencing with bioinformatics and in vitro analyses.
Vitamin A Deficiency
Vitamin a modulates the expression of genes involved in iron bioavailability.