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BRENDA support

Ligand 5'-adenylyl sulfate

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Basic Ligand Information

Molecular Structure
Picture of 5'-adenylyl sulfate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H14N5O10PS
5'-adenylyl sulfate
IRLPACMLTUPBCL-KQYNXXCUSA-N
Synonyms:
5'-adenylylsulfate, 5'-AMP sulfate, 5'-O-[hydroxy(sulfooxy)phosphoryl]adenosine, adenosine-5'-phosphosulfate, adenosine 5'-O-phosphosulfate, adenosine 5'-phosphate 5'-sulfate, adenosine 5'-phosphate sulfate, adenosine 5'-phosphosulfate, adenosine 5-phosphosulfate, adenylyl sulfate, adenylylsulfate


Show all pahtways known for Show all BRENDA pathways known for 5'-adenylyl sulfate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (71 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phosphate + adenosine 5'-phosphosulfate = ADP + SO42-
show the reaction diagram
-
adenylylsulfate + NH3 = adenosine 5'-phosphoramidate + sulfate
show the reaction diagram
-
adenosine 5'-phosphosulfate + dithiothreitol = AMP + ?
show the reaction diagram
-
adenosine 5'-phosphosulfate + H2O = AMP + sulfate
show the reaction diagram
-
adenosine 5'-phosphosulfate + H2O = AMP + SO42-
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
AMP + sulfite + glutathione disulfide = adenylyl sulfate + 2 glutathione
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (194 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phosphate + adenosine 5'-phosphosulfate = ADP + SO42-
show the reaction diagram
-
adenosine 5'-phosphosulfate + H2O = ?
show the reaction diagram
-
adenosine 5'-phosphosulfate + H2O = ?
show the reaction diagram
-
adenosine 5'-phosphosulfate + H2O = AMP + SO42-
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (74 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
AMP + sulfite + glutathione disulfide = adenylyl sulfate + 2 glutathione
show the reaction diagram
-
AMP + 4-nitrophenyl sulfate = adenosine 5'-phosphate 5'-sulfate + 4-nitrophenol
show the reaction diagram
-
5'-AMP + luciferyl sulfate = 5'-AMP sulfate + luciferin
show the reaction diagram
-
3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 5'-phosphosulfate + phosphate
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation, can replace ADP to some extent
-
choline sulfate formation is increased 2.8fold by 10 mM
-

Inhibitor in Enzyme-catalyzed Reactions (248 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate inhibition above 1 mM
-
i.e. APS, strong, reversible by higher PAPS-concentrations
-
above 0.05 mM
-
slight
-
substrate inhibition
-
5 mM: 10-30% inhibition
-
slight
-

3D Structure of Enzyme-Ligand-Complex (PDB) (267 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (43 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (126 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (31 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.3
-
pH 8.5
1.49
-
pH 7.5, 37°C

References & Links

Links to other databases for 5'-adenylyl sulfate