Ligand view of dTDP-4-dehydro-beta-L-rhamnose (16449 - PSXWNITXWWECNY-LPVGZGSHSA-N)

C₁₆H₂₄N₂O₁₅P₂

dTDP-4-dehydro-beta-L-rhamnose

PSXWNITXWWECNY-LPVGZGSHSA-N

BRENDA

KEGG

Biosynthesis of nucleotide sugars, Biosynthesis of secondary metabolites, O-Antigen nucleotide sugar biosynthesis, Polyketide sugar unit biosynthesis, Streptomycin biosynthesis

MetaCyc

dTDP-4-O-demethyl-beta-L-noviose biosynthesis, dTDP-beta-L-rhamnose biosynthesis, dTDP-L-daunosamine biosynthesis, dTDP-sibirosamine biosynthesis, superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis

1.1.1.133

dTDP-4-dehydro-beta-L-rhamnose + NADPH + H+ = dTDP-beta-L-rhamnose + NADP+

-

dTDP-4-dehydro-beta-L-rhamnose + NADPH + H+ = dTDP-beta-L-rhamnose + NADP+

762573

-

1.1.1.339

dTDP-4-dehydro-6-deoxy-beta-L-mannose + NADH + H+ = dTDP-6-deoxy-beta-L-talose + NAD+

285845

-

1.1.1.344

dTDP-6-deoxy-beta-L-lyxo-4-hexulose + NADH + H+ = dTDP-6-deoxy-beta-L-talose + NAD+

711680

-

2.6.1.33

dTDP-4-dehydro-6-deoxy-D-mannose + L-glutamate = dTDP-4-amino-6-deoxy-D-mannose + 2-oxoglutarate

658427

-

2.6.1.59

dTDP-4-dehydro-6-deoxy-D-mannose + L-glutamate = ? + 2-oxoglutarate

-

Biosynthesis of streptomycin. dTDP-dihydrostreptose synthase from Streptomyces griseus and dTDP-4-keto-L-rhamnose 3,5-epimerase from S. griseus and Escherichia coli Y10

1979

Wahl, H.P.; Grisebach, H.

Biochim. Biophys. Acta

568

243-252

2253

238519

Two enzymes in Streptomyces griseus for the synthesis of dTDP-L-dihydrostreptose from dTFP-6-deoxy-D-xylo-4-hexosulose

1975

Wahl, H.P.; Matern, U.; Grisebach, H.

Biochem. Biophys. Res. Commun.

64

1041-1045

2256

1541269

Enzymatic synthesis and isolation of thymidine diphosphate-6-deoxy-D-xylo-4-hexulose and thymidine diphosphate-L-rhamnose

1992

Mamuro, K.; Lindqvist, L.; Verma, N.; Weintraub, A.; Reeves, P.R.; Lindberg, A.A.

Eur. J. Biochem.

204

539-545

285845

10702238

Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans

2000

Nakano, Y.; Suzuki, N.; Yoshida, Y.; Nezu, T.; Yamashita, Y.; Koga, T.

J. Biol. Chem.

275

6806-6812

658427

15271350

Characterization and investigation of substrate specificity of the sugar aminotransferase WecE from E. coli K12

2004

Hwang, B.Y.; Lee, H.J.; Yang, Y.H.; Joo, H.S.; Kim, B.G.

Chem. Biol.

11

915-925

711680

20667525

Cloning and in vitro characterization of dTDP-6-deoxy-L-talose biosynthetic genes from Kitasatospora kifunensis featuring the dTDP-6-deoxy-L-lyxo-4-hexulose reductase that synthesizes dTDP-6-deoxy-L-talose

2010

Karki, S.; Yoo, H.G.; Kwon, S.Y.; Suh, J.W.; Kwon, H.J.

Carbohydr. Res.

345

1958-1962

762573

29199984

Structure of the Bacillus anthracis dTDP-L-rhamnose-biosynthetic enzyme dTDP-4-dehydrorhamnose reductase (RfbD)

2017

Law, A.; Stergioulis, A.; Halavaty, A.S.; Minasov, G.; Anderson, W.F.; Kuhn, M.L.

Acta Crystallogr. Sect. F

73

644-650

Ligand dTDP-4-dehydro-beta-L-rhamnose

Basic Ligand Information

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

Substrate in Enzyme-catalyzed Reactions (5 results)

Product in Enzyme-catalyzed Reactions (5 results)

Enzyme Kinetic Parameters

References & Links

Literature References (7)

Links to other databases for dTDP-4-dehydro-beta-L-rhamnose