Ligand guanine

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Basic Ligand Information

Molecular Structure
Picture of guanine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H5N5O
guanine
UYTPUPDQBNUYGX-UHFFFAOYSA-N
Synonyms:
2-amino-1,9-dihydropurine-6-on, 2-aminohypoxanthine

Show all pahtways known for Show all pathways known for guanine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
guanine + NAD+ + H2O = ? + NADH
show the reaction diagram
guanine + 5-phospho-alpha-D-ribose 1-diphosphate = GMP + diphosphate
show the reaction diagram
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ATP + H2O + guanine/out = ADP + phosphate + guanine/in
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (27 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
guanosine + phosphate = guanine + D-ribose 1-phosphate
show the reaction diagram
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guanosine + phosphate = guanine + D-ribose 1-phosphate
show the reaction diagram
-
-
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate
show the reaction diagram
-
-
guanosine + H2O = D-ribose + guanine
show the reaction diagram
-
-
ATP + H2O + guanine/out = ADP + phosphate + guanine/in
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (45 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
guanine + NAD+ + H2O = ? + NADH
show the reaction diagram
guanine + H2O + O2 = 2-amino-1,7,8-trihydro-6H-purin-8-one + H2O2
show the reaction diagram
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nicotinic acid mononucleotide + guanine = nicotinate + ?
show the reaction diagram
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5-phospho-alpha-D-ribose 1-diphosphate + guanine = GMP + diphosphate
show the reaction diagram
guanine + H2O = xanthine + NH3
show the reaction diagram
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guanine + H2O = xanthine + NH3
show the reaction diagram
-
ATP + H2O + guanine/out = ADP + phosphate + guanine/in
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (127 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
SNAP-Vista Green + [protein]-L-cysteine = guanine + [protein]-S-Vista Green-L-cysteine
show the reaction diagram
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guanosine + phosphate = guanine + D-ribose 1-phosphate
show the reaction diagram
-
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guanosine + phosphate = guanine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate
show the reaction diagram
-
-
GTP + H2O = guanine + D-ribose-5-triphosphate
show the reaction diagram
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guanosine + H2O = 2-amino-1,9-dihydropurine-6-on + D-ribofuranose
show the reaction diagram
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guanosine + H2O = guanine + D-ribose
show the reaction diagram
-
ATP + H2O + guanine/out = ADP + phosphate + guanine/in
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mM, activity: 107%, isoenzyme 2
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Inhibitor in Enzyme-catalyzed Reactions (54 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
48% inhibition
competitive
-
0.1 mM: about 11% inhibition, 1 mM: about 4% inhibition
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0.2 mM, 59% inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (26 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (64 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (187 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.015
-
-

Ki Value (21 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.2
-
above

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0097
-
pH 4.8

References & Links

Links to other databases for guanine

ChEBI
PubChem
ChEBI
PubChem