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Ligand reduced ferredoxin

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Basic Ligand Information

Molecular Structure
Picture of reduced ferredoxin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
Fe2R4S6
reduced ferredoxin
Synonyms:
adrenodoxin, reduced adrenal ferredoxin
Pathway Source
Pathways
MetaCyc
(7Z,10Z,13Z)-hexadecatrienoate biosynthesis, 1,3-dimethylbenzene degradation to 3-methylbenzoate, 1,4-dimethylbenzene degradation to 4-methylbenzoate, 11-oxyandrogens biosynthesis, 2-oxobutanoate degradation II more


Show all pahtways known for Show all BRENDA pathways known for reduced ferredoxin

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (99 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
NADH + H+ + reduced ferredoxin = H2 + NAD+ + oxidized ferredoxin
show the reaction diagram
-
(+)-camphor + reduced ferredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized ferredoxin + H2O
show the reaction diagram
-
cyclo(L-leucyl-L-leucyl) + reduced ferredoxin + O2 = pulcherriminic acid + oxidized ferredoxin + H2O
show the reaction diagram
-
corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O
show the reaction diagram
-
spheroidene + reduced ferredoxin + O2 = spheroiden-2-one + oxidized ferredoxin + H2O
show the reaction diagram
-
4-methoxybenzoate + reduced ferredoxin + O2 = 4-hydroxybenzoate + formaldehyde + ferredoxin + H2O
show the reaction diagram
-
2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin
show the reaction diagram
-
reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+
show the reaction diagram
-
reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H
show the reaction diagram
-
12 reduced ferredoxin + 12 H+ + N2 + 40 ATP + 40 H2O = 12 oxidized ferredoxin + 3 H2 + 2 NH3 + 40 ADP + 40 phosphate
show the reaction diagram
-
reduced ferredoxin + H+ + N2 + ATP = oxidized ferredoxin + H2 + NH3 + ADP + phosphate
show the reaction diagram
-
CO2 + methanofuran + reduced ferredoxin = formylmethanofuran + H2O + oxidized ferredoxin
show the reaction diagram
-
acetate + H+ + reduced ferredoxin = acetaldehyde + H2O + oxidized ferredoxin
show the reaction diagram
-
protochlorophyllide + reduced ferredoxin = chlorophyllide + oxidized ferredoxin
show the reaction diagram
-
biliverdin IXalpha + reduced ferredoxin = 15,16-dihydrobiliverdin + oxidized ferredoxin
show the reaction diagram
-
15,16-dihydrobiliverdin + reduced ferredoxin = (3Z)-phycoerythrobilin + oxidized ferredoxin
show the reaction diagram
-
biliverdin IXalpha + 2 reduced ferredoxin = (3Z)-phycoerythrobilin + 2 oxidized ferredoxin
show the reaction diagram
-
5,10-methylenetetrahydrofolate + reduced ferredoxin = 5-methyltetrahydrofolate + oxidized ferredoxin
show the reaction diagram
-
7,8-dihydromethanopterin + reduced ferredoxin = 5,6,7,8-tetrahydromethanopterin + ferredoxin
show the reaction diagram
-
coenzyme B-coenzyme M disulfide + reduced ferredoxin = coenzyme B + coenzyme M + ferredoxin
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (54 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
H2 + oxidized ferredoxin = H+ + reduced ferredoxin
show the reaction diagram
-
H2 + NAD+ + oxidized ferredoxin = H+ + NADH + reduced ferredoxin
show the reaction diagram
-
11-deoxycortisol + adrenal ferredoxin + H2O = cortisol + reduced adrenal ferredoxin + O2
show the reaction diagram
-
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced ferredoxin
show the reaction diagram
-
NADPH + oxidized ferredoxin = NADP+ + reduced ferredoxin
show the reaction diagram
-
oxalate + oxidized ferredoxin = CO2 + reduced ferredoxin
show the reaction diagram
-
formaldehyde + H2O + oxidized ferredoxin = formate + H+ + reduced ferredoxin
show the reaction diagram
-
1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin
show the reaction diagram
-
15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin
show the reaction diagram
-
(3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin
show the reaction diagram
-
protochlorophyllide + oxidized ferredoxin + ADP + phosphate = chlorophyllide a + reduced ferredoxin + ATP
show the reaction diagram
-
2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+
show the reaction diagram
-
5,10-methylenetetrahydrofolate + ferredoxin = 5-methyltetrahydrofolate + reduced ferredoxin
show the reaction diagram
-
reduced coenzyme F420 + 2 oxidized ferredoxin = oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+
show the reaction diagram
-
hydrogen sulfide + oxidized ferredoxin + H2O = sulfite + reduced ferredoxin + H+
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (206 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
H+ + NADH + reduced ferredoxin = H2 + NAD+ + oxidized ferredoxin
show the reaction diagram
-
reduced ferredoxin = H2 + oxidized ferredoxin
show the reaction diagram
-
(+)-camphor + reduced ferredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized ferredoxin + H2O
show the reaction diagram
-
corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O
show the reaction diagram
-
pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+ = pentalenolactone + 2 oxidized ferredoxin + 2 H2O
show the reaction diagram
-
4-methoxybenzoate + reduced ferredoxin + O2 = 4-hydroxybenzoate + formaldehyde + ferredoxin + H2O
show the reaction diagram
-
2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin
show the reaction diagram
-
reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+
show the reaction diagram
-
12 reduced ferredoxin + 12 H+ + N2 + 40 ATP + 40 H2O = 12 oxidized ferredoxin + 3 H2 + 2 NH3 + 40 ADP + 40 phosphate
show the reaction diagram
-
reduced ferredoxin + H+ + N2 + ATP = oxidized ferredoxin + H2 + NH3 + ADP + phosphate
show the reaction diagram
-
acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+ = pyruvate + CoA + 2 oxidized ferredoxin
show the reaction diagram
-
acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+ = pyruvate + CoA + 2 oxidized ferredoxin
show the reaction diagram
-
CO2 + methanofuran + reduced ferredoxin = formylmethanofuran + H2O + oxidized ferredoxin
show the reaction diagram
-
CO2 + 2 reduced ferredoxin + 2 H+ = CO + H2O + 2 oxidized ferredoxin
show the reaction diagram
-
acetate + H+ + reduced ferredoxin = acetaldehyde + H2O + oxidized ferredoxin
show the reaction diagram
-
protochlorophyllide + reduced ferredoxin = chlorophyllide + oxidized ferredoxin
show the reaction diagram
-
geranylgeraniol + reduced ferredoxin = 14,15-dihydrogeranylgeraniol + oxidized ferredoxin
show the reaction diagram
-
15,16-dihydrobiliverdin + reduced ferredoxin = (3Z)-phycoerythrobilin + oxidized ferredoxin
show the reaction diagram
-
biliverdin IXalpha + 2 reduced ferredoxin = (3Z)-phycoerythrobilin + 2 oxidized ferredoxin
show the reaction diagram
-
5,10-methylenetetrahydrofolate + reduced ferredoxin = 5-methyltetrahydrofolate + oxidized ferredoxin
show the reaction diagram
-
5,10-methylenetetrahydrofolate + reduced ferredoxin = 5-methyltetrahydrofolate + ferredoxin
show the reaction diagram
-
oxidized coenzyme F420 + reduced ferredoxin = reduced coenzyme F420 + oxidized ferredoxin
show the reaction diagram
-
7,8-dihydromethanopterin + reduced ferredoxin = 5,6,7,8-tetrahydromethanopterin + ferredoxin
show the reaction diagram
-
sulfite + a [DsrC protein]-dithiol + 2 reduced ferredoxin + 2 H+ = hydrogen sulfide + a [DsrC protein]-disulfide + 2 oxidized ferredoxin + 3 H2O
show the reaction diagram
-
2 reduced ferredoxin + NAD+ + H+ + Na+in = 2 oxidized ferredoxin + NADH + Na+out
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (131 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
H2 + oxidized ferredoxin = H+ + reduced ferredoxin
show the reaction diagram
-
H2 + ferredoxin = H+ + reduced ferredoxin
show the reaction diagram
-
H2 + oxidized ferredoxin = reduced ferredoxin
show the reaction diagram
-
xanthine + ferredoxin + H2O = urate + reduced ferredoxin
show the reaction diagram
-
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced ferredoxin
show the reaction diagram
-
NADPH + oxidized ferredoxin = NADP+ + reduced ferredoxin
show the reaction diagram
-
hexanal + H2O + 2 oxidized ferredoxin = hexanoate + 2 reduced ferredoxin + 2 H+
show the reaction diagram
-
1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin
show the reaction diagram
-
15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin
show the reaction diagram
-
(3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin
show the reaction diagram
-
(3Z)-phycocyanobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin
show the reaction diagram
-
protochlorophyllide + oxidized ferredoxin + ADP + phosphate = chlorophyllide a + reduced ferredoxin + ATP
show the reaction diagram
-
2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+
show the reaction diagram
-
5,10-methylenetetrahydrofolate + ferredoxin = 5-methyltetrahydrofolate + reduced ferredoxin
show the reaction diagram
-
5-methyltetrahydrofolate + 2 oxidized ferredoxin = 5,10-methylenetetrahydrofolate + 2 reduced ferredoxin + 2 H+
show the reaction diagram
-
reduced coenzyme F420 + 2 oxidized ferredoxin = oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+
show the reaction diagram
-
NH3 + H2O + oxidized ferredoxin = nitrite + reduced ferredoxin + H+
show the reaction diagram
-
nitrite + H2O + oxidized ferredoxin = nitrate + reduced ferredoxin + H+
show the reaction diagram
-
Adrenodoxin precursor + H2O = Adrenodoxin
show the reaction diagram
-

Enzyme Cofactor/Cosubstrate (18 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
required for activity of the recombinant enzyme
-
mouse and bovine adrenodoxin display similar abilities to support CYP27B1 activity
-
organized complexes consisting of adrenodoxin reductase and adrenodoxin are more active in the presence of free adrenodoxin than in its absence
-
reduced flavodoxin is te better cofactor
-
reactivation after purification
-
required
-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
oxidized form, high affinity to P-450scc, inhibits side chain cleavage by competition with reduced form
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (43 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
3.3
-
pH 7.4, 30°C, wild-type ferredoxin from the cyanobacterium Anabaena PCC 7119
0.51
-
wild-type, pH 7.0, temperature not specified in the publication
37
-
pH 7.5, 37°C

KM Value (93 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00025
-
pH and temperature not specified in the publication
0.0075
-
-
0.00314
-
pH 7.4, 30°C, wild-type ferredoxin from the cyanobacterium Anabaena PCC 7119
0.016
-
-
0.002
-
pH 7.5, 37°C
0.0005
-
pH 7.0, temperature not specified in the publication

References & Links