Ligand (10E,12Z)-9-hydroperoxy-10,12-octadecadienoate

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Basic Ligand Information

Molecular Structure

C₁₈H₃₂O₄

(10E,12Z)-9-hydroperoxy-10,12-octadecadienoate

JGUNZIWGNMQSBM-ZJHFMPGASA-N

Synonyms:

(8R,9Z,12Z)-9-hydroperoxy-10,12-octadecadienoate, 9-hydroperoxy-(10E,12Z)-octadecadienoic acid, 9-hydroperoxy-10E,12Z-octadecadienoic acid, 9-hydroperoxyoctadecadienoic acid, 9-hydroperoxy octadecadienoic acid

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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1.13.11.12

linoleate + O2 = 9-hydroperoxy octadecadienoic acid + 13-hydroperoxy octadecadienoic acid

1.13.11.58

linoleate + O2 = (10E,12Z)-9-hydroperoxy-10,12-octadecadienoate

Substrate in Enzyme-catalyzed Reactions (1 result)

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5.4.4.5

(8R,9Z,12Z)-9-hydroperoxy-10,12-octadecadienoate = (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate

711024

Product in Enzyme-catalyzed Reactions (6 results)

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1.13.11.12

linoleate + O2 = 9-hydroperoxy octadecadienoic acid + 13-hydroperoxy octadecadienoic acid

1.13.11.34

linoleic acid + O2 = 9-hydroperoxyoctadecadienoic acid

0, 439454

1.13.11.45

alpha-linolenic acid + O2 = (13R)-hydroperoxy octadecadienoic acid + 9-hydroperoxyoctadecadienoic acid

1.13.11.58

linoleate + O2 = (10E,12Z)-9-hydroperoxy-10,12-octadecadienoate

1.13.11.B6

2 entries

Activator in Enzyme-catalyzed Reactions (1 result)

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1.11.1.12

9-HpODE, induces a dose-dependent intracellular increase in GSH oxidation that is independent of intracellular H2O2 production and is mediated by glutathione peroxidase 4 (GPx4) in BEAS-2B cells. Glucose deprivation potentiates the oxidative effect of 9-HpODE on GSH and inhibits its recovery

764204