Ligand uracil

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Basic Ligand Information

Molecular Structure

C₄H₄N₂O₂

uracil

ISAKRJDGNUQOIC-UHFFFAOYSA-N

Synonyms:

6-hydroxy-1H-pyrimidin-2-one

Show all BRENDA pathways known for uracil

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (32 results)

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alpha-D-ribose 1-phosphate + uracil = phosphate + uridine

uracil + 2-deoxy-alpha-D-ribose 1-phosphate = 2'-deoxyuridine + phosphate

2 O3-acetyl-L-serine + 2 uracil = 3-(uracil-1-yl)-L-alanine + 3-(uracil-3-yl)-L-alanine + 2 acetate

638057

4.2.1.70

4 entries

In Vivo Product in Enzyme-catalyzed Reactions (67 results)

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1.14.11.10

2'-deoxyuridine + 2-oxoglutarate + O2 = uracil + deoxyribonolactone + succinate + CO2

1.3.1.1

5,6-dihydrouracil + NAD+ = uracil + NADH + H+

2'-deoxy-D-ribosyl-uracil + adenine = 2'-deoxy-D-ribosyl-adenine + uracil

uracil-mismatched double-stranded DNA + H2O = uracil + double-stranded DNA with abasic site

3.2.2.29

uracil-mismatched double-stranded DNA + H2O = uracil + double-stranded DNA with abasic site

3.2.2.3

7 entries

3.5.4.1

cytosine + H2O = uracil + NH3

Substrate in Enzyme-catalyzed Reactions (59 results)

uracil + 2-oxoglutarate + O2 = ? + succinate + CO2

uracil + phosphoribose diphosphate = diphosphate + uridine

489714

2.4.2.2

alpha-D-ribose 1-phosphate + uracil = phosphate + uridine

2 O3-acetyl-L-serine + 2 uracil = 3-(uracil-1-yl)-L-alanine + 3-(uracil-3-yl)-L-alanine + 2 acetate

638056, 638057

3.5.2.14

ATP + uracil + H2O = ?

uracil + H2O = ?

Product in Enzyme-catalyzed Reactions (339 results)

2'-methyluridine 5'-diphosphate + reduced dithiothreitol = uracil + H2O + ?

437973

1.2.3.1

2-hydroxypyrimidine + H2O + O2 = uracil + H2O2

1.3.1.1

5,6-dihydrouracil + NAD+ = uracil + NADH + H+

1.3.1.2

6 entries

1.3.3.7

5,6-dihydrouracil + O2 = uracil + H2O2

391073

2.4.2.1

uridine + phosphate = uracil + alpha-D-ribose 1-phosphate

guanine + uridine = guanosine + uracil

639646

2.4.2.57

UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate

uridine + H2O = D-ribose + uracil

3.2.2.27

154 entries

3.2.2.28

uracil-mismatched double-stranded DNA + H2O = uracil + double-stranded DNA with abasic site

3.2.2.29

uracil-mismatched double-stranded DNA + H2O = uracil + double-stranded DNA with abasic site

cytosine + H2O = uracil + NH3

3.5.4.21

cytosine + H2O = uracil + NH3

3.5.4.3

cytosine + H2O = 6-hydroxy-1H-pyrimidin-2-one + NH3

4.1.1.23

orotate = uracil + CO2

4.1.1.66

Uracil-5-carboxylate = Uracil + CO2

Activator in Enzyme-catalyzed Reactions (3 results)

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2.4.1.229

stimulates the purified enzyme at 0.1 mM

639556

3.5.2.2

induces biosynthesis of enzyme

209300

4.1.1.23

1 mM, 1.3fold stimulation

651345

Inhibitor in Enzyme-catalyzed Reactions (99 results)

reversible inhibition

competitive vs. dihydrouracil

391073

1.3.98.1

orotate analogue, 50% inhibition at 2.5 mM

390927

2.4.2.10

489712, 489727, 659903

2.4.2.16

1 mM, about 85% inhibition

strong feedback inhibition

3D Structure of Enzyme-Ligand-Complex (PDB) (85 results)

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (15 results)

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1.3.1.1

0.64

pH 6.0, 30Â°C

K_M Value (54 results)

0.2

0.131

0.038

pH 6.0, 30Â°C

2.63

6.6

K_i Value (8 results)

0.2

0.035

0.1212

pH 8.0, 37Â°C

0.808

0.158

tumor tissue

638462

IC₅₀ Value (2 results)

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6.3.4.2

2 entries

References & Links

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Show Reference (169 entries)

Links to other databases for uracil

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Ligand uracil

Basic Ligand Information

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (32 results)

In Vivo Product in Enzyme-catalyzed Reactions (67 results)

Substrate in Enzyme-catalyzed Reactions (59 results)

Product in Enzyme-catalyzed Reactions (339 results)

Activator in Enzyme-catalyzed Reactions (3 results)

Inhibitor in Enzyme-catalyzed Reactions (99 results)

3D Structure of Enzyme-Ligand-Complex (PDB) (85 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (15 results)

KM Value (54 results)

Ki Value (8 results)

IC50 Value (2 results)

References & Links

Literature References (169)

Links to other databases for uracil

k_cat Value (Turnover Number) (15 results)

K_M Value (54 results)

K_i Value (8 results)

IC₅₀ Value (2 results)