Ligand 5-Iodouracil

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Basic Ligand Information

Molecular Structure
Picture of 5-Iodouracil (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H3IN2O2
5-Iodouracil
HDYANYHVCAPMJV-LXQIFKJMSA-N
Synonyms:
5-Iodo-uracil, iodouracil

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2'-deoxyuridine + 5-iodouracil = 5-iodo-2'-deoxyuridine + uracil
show the reaction diagram
-
deoxyadenosine + 5-iodouracil = adenine + deoxy-5-iodouridine
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
uracil + I- + H2O2 = 5-iodouracil + H2O
show the reaction diagram
-
I- + H2O2 + uracil = 5-iodouracil + H2O
show the reaction diagram
-
iododeoxyuridine + phosphate = iodouracil + 2-deoxy-D-ribose
show the reaction diagram
5-iodouridine + H2O = 5-iodouracil + D-ribose
show the reaction diagram
-
5-iodocytosine + H2O = 5-iodouracil + NH3
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive vs. dihydrouracil
-
IC50: 0.071 mM
-
His116 directly interacts with the inhibitor via its NE2 group, enzyme binding structure, overview
84% inhibition at 1 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (7 results)

Enzyme Kinetic Parameters

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.088
-
-
0.48
-
-

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.071
-
IC50: 0.071 mM

References & Links

Links to other databases for 5-Iodouracil

ChEBI
PubChem
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PubChem