Ligand benzene-1,2,4-triol

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Basic Ligand Information

Molecular Structure
Picture of benzene-1,2,4-triol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H6O3
benzene-1,2,4-triol
GGNQRNBDZQJCCN-UHFFFAOYSA-N
Synonyms:
1,2,4-Benzenetriol, 1,2,4-Trihydroxybenzene, 2,5-dihydroxyphenol, 2-hydroxy-1,4-benzoquinol, benzene-1,2,5-triol, Hydroxyhydroquinone, Hydroxyquinol


Show all pahtways known for Show all BRENDA pathways known for benzene-1,2,4-triol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
resorcinol + NADPH + H+ + O2 = hydroxyquinol + NADP+ + H2O
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resorcinol + NADH + H+ + O2 = hydroxyquinol + NAD+ + H2O
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resorcinol + FADH2 + O2 = hydroxyquinol + FAD + H2O
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Substrate in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,2,4-benzenetriol + O2 = ?
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hydroxyhydroquinone + O2 = hydroxyquinone + H2O
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1,2,4-benzenetriol + NADH + O2 = ?
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hydroxyhydroquinone + O2 = 2-hydroxy-p-benzoquinone + H2O
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UDP-alpha-D-glucose + 1,2,4-benzenetriol = UDP + ?
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Product in Enzyme-catalyzed Reactions (30 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-nitrocatechol + NADH + H+ + O2 = 1,2,4-trihydroxybenzene + nitrite + NAD+ + H2O
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resorcinol + NADPH + H+ + O2 = hydroxyquinol + NADP+ + H2O
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resorcinol + NADH + H+ + O2 = hydroxyquinol + NAD+ + H2O
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resorcinol + NADH + O2 = hydroxyquinol + NAD+ + H2O
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quinol + O2 + NADPH = 1,2,4-trihydroxybenzene + NADP+ + H2O
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quinol + O2 + NADPH = 1,2,4-trihydroxybenzene + NADP+ + H2O
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resorcinol + FADH2 + O2 = hydroxyquinol + FAD + H2O
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2-hydroxy-[1,4]-benzoquinone + NADH = 1,2,4-trihydroxybenzene + NAD+
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2-hydroxy-1,4-benzoquinone + NADH = 2-hydroxy-1,4-benzoquinol + NAD+
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2,3,5-Trihydroxybenzoate = 1,2,4-Trihydroxybenzene + CO2
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Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.2 mM, 9% residual activity
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (5 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.28
-
in 50 mM Tris/HCl, pH 7.2, 25°C
229
-
pH and temperature not specified in the publication

KM Value (7 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.097
-
in 50 mM Tris/HCl, pH 7.2, 25°C
0.4
-
pH and temperature not specified in the publication

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.063
-
pH and temperature not specified in the publication

References & Links

Links to other databases for benzene-1,2,4-triol

ChEBI
PubChem
ChEBI
PubChem