print visible entries

print all entries

Ligand xylitol

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for xylitol

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (20 results)

top print hide

Show Natural Substrate (20 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.10

xylitol + NADP+ = L-xylulose + NADPH + H+

740206, 721689, 760730, 761647

-

1.1.1.10

xylitol + NADP+ = xylulose + NADPH + H+

761812

-

1.1.1.10

2 entries

1.1.1.12

xylitol + NAD+ = D-xylulose + NADH + H+

761551

-

1.1.1.14

xylitol + NAD+ = D-xylulose + NADH + H+

285884

-

1.1.1.16

xylitol + NAD+ = ? + NADH

389406

-

1.1.1.307

xylitol + NAD(P)+ = D-xylose + NAD(P)H + H+

760714

-

1.1.1.307

xylitol + NAD+ = D-xylose + NADH + H+

721343, 722851, 721848

-

1.1.1.307

xylitol + NADP+ = D-xylose + NADPH + H+

721343, 721848, 740206, 722851

-

1.1.1.307

3 entries

1.1.1.406

xylitol + NAD+ = L-xylulose + NADH + H+

712439, 389404

-

1.1.1.431

xylitol + NAD+ = D-xylose + NADH + H+

740782

-

1.1.1.431

xylitol + NADP+ = D-xylose + NADPH + H+

740782, 760367, 760720

-

1.1.1.9

Xylitol + NAD+ = ?

246420, 246418, 246417

-

1.1.1.9

xylitol + NAD+ = D-xylulose + NADH + H+

722851, 721913, 722437, 760272, 738796, 743029, 737895, 742941, 696889, 700010, 740772, 742925, 742720, 722304, 738797, 743034, 760714, 761562, 742112, 738728, 761551, 742937, 760758, 761832, 761107, 738725, 737866, 667268, 699148, 699368

-

1.1.1.431

2 entries

1.1.1.9

2 entries

1.1.1.B19

xylitol + NAD+ = L-xylulose + NADH + H+

761105, 760875, 742941, 743034, 762303

-

1.1.1.B64

xylitol + NADP+ = D-xylulose + NADPH + H+

742151

-

1.1.3.4

xylitol + O2 = ?

695833

-

1.1.3.41

xylitol + O2 = ?

695833

2vfs, 3D-view

1.1.3.41

xylitol + O2 = xylose + H2O2

740457, 724756

2vfs, 3D-view

1.1.3.41

2 entries

2.7.1.122

xylitol + ? = xylitol 5-phosphate + ?

640692

-

2.7.1.17

ATP + D-xylitol = ADP + D-xylitol-5-phosphate

761563

-

In Vivo Product in Enzyme-catalyzed Reactions (14 results)

top print hide

Show Natural Product (14 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.10

L-xylulose + NADH = L-xylitol + NAD+

0

-

1.1.1.10

L-xylulose + NADPH + H+ = L-xylitol + NADP+

285665, 0

-

1.1.1.10

L-xylulose + NADPH + H+ = xylitol + NADP+

0

-

1.1.1.307

D-xylose + NAD(P)H + H+ = xylitol + NAD(P)+

0

-

1.1.1.307

D-xylose + NADH + H+ = xylitol + NAD+

0

-

1.1.1.307

D-xylose + NADPH + H+ = xylitol + NADP+

0

-

1.1.1.430

D-xylose + NAD(P)H + H+ = xylitol + NAD(P)+

0

-

1.1.1.430

D-xylose + NADH + H+ = xylitol + NAD+

0

-

1.1.1.430

D-xylose + NADPH + H+ = xylitol + NADP+

0

-

1.1.1.431

D-xylose + NAD(P)H + H+ = xylitol + NAD(P)+

0

-

1.1.1.431

D-xylose + NADH + H+ = xylitol + NAD+

0

-

1.1.1.431

D-xylose + NADPH + H+ = xylitol + NADP+

0

-

1.1.1.10

3 entries

1.1.1.307

3 entries

1.1.1.430

3 entries

1.1.1.431

3 entries

1.1.1.9

D-xylulose + NADH + H+ = xylitol + NAD+

0

-

3.1.3.58

D-xylitol-5-phosphate + H2O = D-xylitol + phosphate

646416

-

Substrate in Enzyme-catalyzed Reactions (55 results)

top print hide

Show Substrate (55 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.10

xylitol + NAD+ = L-xylulose + NADH + H+

656049

-

1.1.1.10

xylitol + NADP+ = L-xylulose + NADPH + H+

246414, 246419, 285663, 285664, 670839, 285665, 740206, 246420, 285666, 287033, 721689, 760730, 761647, 285658, 740782

-

1.1.1.10

xylitol + NADP+ = xylulose + NADPH + H+

761812

-

1.1.1.11

Xylitol + NAD+ = ?

285753, 285754, 9566

-

1.1.1.11

xylitol + NAD+ = D-xylulose + NADH + H+

701082, 760713

-

1.1.1.12

Xylitol + NAD+ = ?

684627, 246416, 669541

-

1.1.1.12

xylitol + NAD+ = D-xylulose + NADH + H+

655390, 696988, 711121, 712767, 761551

-

1.1.1.12

xylitol + NADP+ = D-xylulose + NADPH + H+

761551

-

1.1.1.14

D-xylitol + NAD+ = ?

285882, 285887, 285872, 285876, 285879, 285881, 686021, 285895, 285880, 285883, 285901, 285897, 285874, 285888, 285884, 285899, 285890, 285886

-

1.1.1.14

D-xylitol + NAD+ = ? + NADH + H+

736022

-

1.1.1.14

D-xylitol + NADP+ = ? + NADPH + H+

736022

-

1.1.1.14

Xylitol + NAD+ = ?

670513

-

1.1.1.14

xylitol + NAD+ = D-xylulose + NADH + H+

285884

-

1.1.1.16

xylitol + NAD+ = ? + NADH

389406

-

1.1.1.16

xylitol + NAD+ = L-xylulose + NADH + H+

740390

-

1.1.1.10

3 entries

1.1.1.11

2 entries

1.1.1.12

3 entries

1.1.1.14

5 entries

1.1.1.16

2 entries

1.1.1.21

xylitol + NAD(P)+ = D-xylose + NAD(P)H + H+

286249, 286221, 286240, 286241, 286244, 286245, 286247, 286248, 286250, 286251, 286255, 286258, 286260, 286259

-

1.1.1.250

D-xylitol + NAD+ = D-xylulose + NADH + H+

721370, 746873

-

1.1.1.250

Xylitol + NAD+ = ?

9566

-

1.1.1.250

2 entries

1.1.1.287

xylitol + NAD+ = D-xylulose + NADH + H+

701082

-

1.1.1.289

D-xylitol + NADP+ = D-xylose + NADPH + H+

724644

-

1.1.1.307

xylitol + NAD(P)+ = D-xylose + NAD(P)H + H+

760714, 762689

-

1.1.1.307

xylitol + NAD+ = D-xylose + NADH + H+

721343, 722851, 721848, 764945

-

1.1.1.307

xylitol + NADP+ = D-xylose + NADPH + H+

721343, 721848, 740206, 764945, 722851

-

1.1.1.307

3 entries

1.1.1.406

xylitol + NAD+ = L-xylulose + NADH + H+

712439, 389404

-

1.1.1.431

xylitol + NAD+ = D-xylose + NADH + H+

740782, 760720

-

1.1.1.431

xylitol + NADP+ = D-xylose + NADPH + H+

764945, 740782, 760367, 760720

-

1.1.1.56

D-xylitol + NAD+ = ? + NADH + H+

763625

-

1.1.1.56

xylitol + NAD+ = D-xylulose + NADH + H+

287125, 287121, 287123, 287126, 287115, 287120

-

1.1.1.9

D-xylitol + NAD+ = D-xylulose + NADH + H+

655894, 656363, 656741, 655053, 655092, 654231, 655221

-

1.1.1.9

Xylitol + NAD+ = ?

246420, 246418, 246417

-

1.1.1.9

xylitol + NAD+ = D-xylulose + NADH + H+

246419, 246414, 246428, 722851, 684974, 246416, 246415, 246420, 699368, 246423, 246426, 246421, 721913, 722437, 760272, 246425, 738796, 743029, 246422, 687872, 688749, 737895, 742941, 246427, 246417, 246424, 684600, 696889, 700010, 740772, 742925, 670911, 742720, 667227, 710975, 669305, 722304, 738797, 743034, 760714, 761562, 742112, 738728, 761551, 742937, 760758, 761832, 761107, 738725, 737866, 667268, 699148

-

1.1.1.9

xylitol + NAD+ = L-xylulose + NADH + H+

686433, 740782

-

1.1.1.9

xylitol + NADP+ = D-xylulose + NADPH + H+

688749, 669305, 670911, 737866, 761551

-

1.1.1.B19

xylitol + NAD+ = L-xylulose + NADH + H+

761105, 760875, 742941, 743034, 762303, 711517

-

1.1.1.B19

xylitol + NAD+ = xylulose + NADH + H+

760329

-

1.1.1.431

2 entries

1.1.1.56

2 entries

1.1.1.9

5 entries

1.1.1.B19

2 entries

1.1.1.B64

xylitol + NADP+ = D-xylulose + NADPH + H+

742151, 742112

-

1.1.3.4

xylitol + O2 = ?

695833, 695424

-

1.1.3.41

xylitol + O2 = ?

695833, 695424

2vfs, 3D-view

1.1.3.41

xylitol + O2 = D-xylose + H2O2

695424

2vfs, 3D-view

1.1.3.41

xylitol + O2 = xylose + H2O2

740457, 440251, 724072, 724756

2vfs, 3D-view

1.1.3.41

3 entries

1.1.5.2

xylitol + phenazine methosulfate = ?

746918

-

1.1.5.5

xylitol + 2,6-dichlorophenolindophenol = ? + reduced 2,6-dichlorophenolindophenol

741374

-

2.4.1.162

sucrose + xylitol = ?

692116

-

2.4.1.162

sucrose + xylitol = D-glucose + beta-D-fructofuranosyl-(2->1)-xylitol

488677

-

2.4.1.7

D-xylitol + alpha-D-glucose 1-phosphate = ? + phosphate

657623

-

2.4.1.7

alpha-D-glucose-1-phosphate + xylitol = 4-O-alpha-D-glucopyranosyl-xylitol + phosphate

637847

-

2.4.1.7

sucrose + xylitol = ?

679550

-

2.4.1.162

2 entries

2.4.1.7

3 entries

2.7.1.122

xylitol + ? = xylitol 5-phosphate + ?

640692

-

2.7.1.17

ATP + D-xylitol = ADP + ?

674223

-

2.7.1.17

ATP + D-xylitol = ADP + D-xylitol-1-phosphate

688820

-

2.7.1.17

ATP + D-xylitol = ADP + D-xylitol-5-phosphate

761563, 688820

-

2.7.1.17

ATP + xylitol = ADP + ?

675423, 645051

-

2.7.1.17

4 entries

3.1.1.17

xylitol + H2O = ?

730719

4gna, 3D-view

3.2.1.52

di-N-acetylchitobiose + xylitol = ?

655769

-

3.2.1.52

N,N'-diacetylchitobiose + xylitol = 1-O-beta-D-N-acetylglucosaminyl xylitol

751231

-

3.2.1.52

2 entries

Product in Enzyme-catalyzed Reactions (38 results)

top print hide

Show Product (38 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.10

D-xylulose + NADPH + H+ = D-xylitol + NADP+

0

-

1.1.1.10

L-xylulose + NADH = L-xylitol + NAD+

0

-

1.1.1.10

L-xylulose + NADPH + H+ = L-xylitol + NADP+

285663, 285664, 0, 285665, 287033

-

1.1.1.10

D-xylulose + NADPH + H+ = xylitol + NADP+

0

-

1.1.1.10

L-xylulose + NADH + H+ = xylitol + NAD+

0

-

1.1.1.10

L-xylulose + NADPH + H+ = xylitol + NADP+

0

-

1.1.1.10

6 entries

1.1.1.138

xylose + NADPH + H+ = xylitol + NADP+

0

-

1.1.1.19

D-xylose + NADPH + H+ = D-xylitol + NADP+

0

-

1.1.1.21

D-xylose + NADPH + H+ = D-xylitol + NADP+

0

-

1.1.1.21

D-xylulose + NADPH + H+ = D-xylitol + NADP+

0

-

1.1.1.21

L-xylose + NAD(P)H = L-xylitol + NAD(P)+

0

-

1.1.1.21

D-xylose + NAD(P)H = xylitol + NAD(P)+

0

-

1.1.1.21

D-xylose + NADPH + H+ = xylitol + NADP+

0

-

1.1.1.21

D-xylose + NADPH = xylitol + NADP+

0

-

1.1.1.21

L-xylose + NADP+ = xylitol + NADPH + H+

0

-

1.1.1.21

7 entries

1.1.1.250

D-xylulose + NADH + H+ = D-xylitol + NAD+

0

-

1.1.1.307

D-xylose + NAD(P)H + H+ = xylitol + NAD(P)+

0

-

1.1.1.307

D-xylose + NADH + H+ = xylitol + NAD+

0

-

1.1.1.307

D-xylose + NADPH + H+ = xylitol + NADP+

0

-

1.1.1.307

DL-glyceraldehyde + NADH + H+ = xylitol + NAD+

0

-

1.1.1.430

D-xylose + NAD(P)H + H+ = xylitol + NAD(P)+

0

-

1.1.1.430

D-xylose + NADH + H+ = xylitol + NAD+

0

-

1.1.1.430

D-xylose + NADPH + H+ = xylitol + NADP+

0

-

1.1.1.431

D-xylose + NAD(P)H + H+ = xylitol + NAD(P)+

0

-

1.1.1.431

D-xylose + NADH + H+ = xylitol + NAD+

0

-

1.1.1.431

D-xylose + NADPH + H+ = xylitol + NADP+

0

-

1.1.1.307

4 entries

1.1.1.430

3 entries

1.1.1.431

3 entries

1.1.1.67

D-xylose + NADH + H+ = D-xylitol + NAD+

0

-

1.1.1.72

D-xylose + NADPH = xylitol + NADP+

0

-

1.1.1.9

D-xylulose + NADH + H+ = D-xylitol + NAD+

0

-

1.1.1.9

L-xylulose + NADH = L-xylitol + NAD+

0

-

1.1.1.9

D-xylulose + NAD+ = xylitol + NADH + H+

0

-

1.1.1.9

D-xylulose + NADH + H+ = xylitol + NAD+

246414, 246428, 246416, 246415, 246420, 246426, 246417, 0

-

1.1.1.9

4 entries

1.1.1.B19

D-xylulose + NADH + H+ = xylitol + NAD+

0

-

1.1.99.28

D-glucose + D-xylose = D-gluconolactone + D-xylitol

0

-

3.1.3.58

D-xylitol-5-phosphate + H2O = D-xylitol + phosphate

646416

-

3.2.1.139

4-O-methyl-D-glucuronosyl-xylitol + H2O = 4-O-methyl-D-glucuronate + xylitol

0

-

3.2.1.37

xylobiosylxylitol + H2O = xylose + xylitol

136315

-

3.2.1.37

xylosylxylitol + H2O = xylose + xylitol

136315

-

3.2.1.37

2 entries

Activator in Enzyme-catalyzed Reactions (19 results)

top print hide

Show Activating Compound (19 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.11

increase of activity

488450

-

3.1.1.72

slightly induces enzyme expression, gene axeII

650507

-

5.3.1.5

-

671399

1s5n, 3D-view

5.3.1.5

-

671399

1xig, 3D-view

5.3.1.5

-

671399

1xim, 3D-view

5.3.1.5

-

671399

1xin, 3D-view

5.3.1.5

-

671399

1xlc, 3D-view

5.3.1.5

-

671399

1xld, 3D-view

5.3.1.5

-

671399

1xlg, 3D-view

5.3.1.5

-

671399

1xlj, 3D-view

5.3.1.5

-

671399

1xlm, 3D-view

5.3.1.5

-

671399

2xim, 3D-view

5.3.1.5

-

671399

2xis, 3D-view

5.3.1.5

-

671399

3gnx, 3D-view

5.3.1.5

-

671399

4duo, 3D-view

5.3.1.5

-

671399

5nh6, 3D-view

5.3.1.5

-

671399

5xia, 3D-view

5.3.1.5

-

671399

5y4j, 3D-view

5.3.1.5

-

671399

7dfk, 3D-view

5.3.1.5

17 entries

Inhibitor in Enzyme-catalyzed Reactions (79 results)

top print hide

Show Inhibitors (79 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.430

non-competitive against NADH and D-xylose

695731

-

2.4.1.7

-

637847

-

3.2.1.1

competitive

393371

-

3.2.1.26

inhibitory action at 35 and 40% solution

701080

-

5.1.3.3

competitive

2369

-

5.3.1.25

-

2685, 2686

-

5.3.1.3

-

2685, 2686

-

5.3.1.4

-

2718, 2720

-

5.3.1.4

46% residual activity at 10 mM

726893

-

5.3.1.4

remaining activity 50.0%

662489

-

5.3.1.4

weak inhibitor

674224, 677266

-

5.3.1.5

-

2736, 2738, 2746, 2771, 2772

1s5n, 3D-view

5.3.1.5

-

2736, 2738, 2746, 2771, 2772

1xig, 3D-view

5.3.1.5

-

2736, 2738, 2746, 2771, 2772

1xim, 3D-view

5.3.1.5

-

2736, 2738, 2746, 2771, 2772

1xin, 3D-view

5.3.1.5

-

2736, 2738, 2746, 2771, 2772

1xlc, 3D-view

5.3.1.5

-

2736, 2738, 2746, 2771, 2772

1xld, 3D-view

5.3.1.5

-

2736, 2738, 2746, 2771, 2772

1xlg, 3D-view

5.3.1.5

-

2736, 2738, 2746, 2771, 2772

1xlj, 3D-view

5.3.1.5

-

2736, 2738, 2746, 2771, 2772

1xlm, 3D-view

5.3.1.5

-

2736, 2738, 2746, 2771, 2772

2xim, 3D-view

5.3.1.5

-

2736, 2738, 2746, 2771, 2772

2xis, 3D-view

5.3.1.5

-

2736, 2738, 2746, 2771, 2772

3gnx, 3D-view

5.3.1.5

-

2736, 2738, 2746, 2771, 2772

4duo, 3D-view

5.3.1.5

-

2736, 2738, 2746, 2771, 2772

5nh6, 3D-view

5.3.1.5

-

2736, 2738, 2746, 2771, 2772

5xia, 3D-view

5.3.1.5

-

2736, 2738, 2746, 2771, 2772

5y4j, 3D-view

5.3.1.5

-

2736, 2738, 2746, 2771, 2772

7dfk, 3D-view

5.3.1.5

competitive

2731, 2751, 2754, 2773

1s5n, 3D-view

5.3.1.5

competitive

2731, 2751, 2754, 2773

1xig, 3D-view

5.3.1.5

competitive

2731, 2751, 2754, 2773

1xim, 3D-view

5.3.1.5

competitive

2731, 2751, 2754, 2773

1xin, 3D-view

5.3.1.5

competitive

2731, 2751, 2754, 2773

1xlc, 3D-view

5.3.1.5

competitive

2731, 2751, 2754, 2773

1xld, 3D-view

5.3.1.5

competitive

2731, 2751, 2754, 2773

1xlg, 3D-view

5.3.1.5

competitive

2731, 2751, 2754, 2773

1xlj, 3D-view

5.3.1.5

competitive

2731, 2751, 2754, 2773

1xlm, 3D-view

5.3.1.5

competitive

2731, 2751, 2754, 2773

2xim, 3D-view

5.3.1.5

competitive

2731, 2751, 2754, 2773

2xis, 3D-view

5.3.1.5

competitive

2731, 2751, 2754, 2773

3gnx, 3D-view

5.3.1.5

competitive

2731, 2751, 2754, 2773

4duo, 3D-view

5.3.1.5

competitive

2731, 2751, 2754, 2773

5nh6, 3D-view

5.3.1.5

competitive

2731, 2751, 2754, 2773

5xia, 3D-view

5.3.1.5

competitive

2731, 2751, 2754, 2773

5y4j, 3D-view

5.3.1.5

competitive

2731, 2751, 2754, 2773

7dfk, 3D-view

5.3.1.5

-

651118, 661142, 701788

1s5n, 3D-view

5.3.1.5

-

651118, 661142, 701788

1xig, 3D-view

5.3.1.5

-

651118, 661142, 701788

1xim, 3D-view

5.3.1.5

-

651118, 661142, 701788

1xin, 3D-view

5.3.1.5

-

651118, 661142, 701788

1xlc, 3D-view

5.3.1.5

-

651118, 661142, 701788

1xld, 3D-view

5.3.1.5

-

651118, 661142, 701788

1xlg, 3D-view

5.3.1.5

-

651118, 661142, 701788

1xlj, 3D-view

5.3.1.5

-

651118, 661142, 701788

1xlm, 3D-view

5.3.1.5

-

651118, 661142, 701788

2xim, 3D-view

5.3.1.5

-

651118, 661142, 701788

2xis, 3D-view

5.3.1.5

-

651118, 661142, 701788

3gnx, 3D-view

5.3.1.5

-

651118, 661142, 701788

4duo, 3D-view

5.3.1.5

-

651118, 661142, 701788

5nh6, 3D-view

5.3.1.5

-

651118, 661142, 701788

5xia, 3D-view

5.3.1.5

-

651118, 661142, 701788

5y4j, 3D-view

5.3.1.5

-

651118, 661142, 701788

7dfk, 3D-view

5.3.1.5

inhibits in vitro xylose isomerase activity severely and competitively

713924

1s5n, 3D-view

5.3.1.5

inhibits in vitro xylose isomerase activity severely and competitively

713924

1xig, 3D-view

5.3.1.5

inhibits in vitro xylose isomerase activity severely and competitively

713924

1xim, 3D-view

5.3.1.5

inhibits in vitro xylose isomerase activity severely and competitively

713924

1xin, 3D-view

5.3.1.5

inhibits in vitro xylose isomerase activity severely and competitively

713924

1xlc, 3D-view

5.3.1.5

inhibits in vitro xylose isomerase activity severely and competitively

713924

1xld, 3D-view

5.3.1.5

inhibits in vitro xylose isomerase activity severely and competitively

713924

1xlg, 3D-view

5.3.1.5

inhibits in vitro xylose isomerase activity severely and competitively

713924

1xlj, 3D-view

5.3.1.5

inhibits in vitro xylose isomerase activity severely and competitively

713924

1xlm, 3D-view

5.3.1.5

inhibits in vitro xylose isomerase activity severely and competitively

713924

2xim, 3D-view

5.3.1.5

inhibits in vitro xylose isomerase activity severely and competitively

713924

2xis, 3D-view

5.3.1.5

inhibits in vitro xylose isomerase activity severely and competitively

713924

3gnx, 3D-view

5.3.1.5

inhibits in vitro xylose isomerase activity severely and competitively

713924

4duo, 3D-view

5.3.1.5

inhibits in vitro xylose isomerase activity severely and competitively

713924

5nh6, 3D-view

5.3.1.5

inhibits in vitro xylose isomerase activity severely and competitively

713924

5xia, 3D-view

5.3.1.5

inhibits in vitro xylose isomerase activity severely and competitively

713924

5y4j, 3D-view

5.3.1.5

inhibits in vitro xylose isomerase activity severely and competitively

713924

7dfk, 3D-view

5.3.1.4

4 entries

5.3.1.5

68 entries

3D Structure of Enzyme-Ligand-Complex (PDB) (57 results)

top print hide

Show 3D Structure of Enzyme-Ligand-Complex (PDB) (57 entries)

EC NUMBER

ENZYME 3D STRUCTURE

1.1.3.41

2vfs, 3D-view

3.1.1.17

4gna, 3D-view

3.2.1.50

4xwh, 3D-view

3.6.3.17

4rs3, 3D-view

4.2.2.1

1w3y, 3D-view

5.3.1.5

1s5n, 3D-view

5.3.1.5

1xig, 3D-view

5.3.1.5

1xim, 3D-view

5.3.1.5

1xin, 3D-view

5.3.1.5

1xlc, 3D-view

5.3.1.5

1xld, 3D-view

5.3.1.5

1xlg, 3D-view

5.3.1.5

1xlj, 3D-view

5.3.1.5

1xlm, 3D-view

5.3.1.5

2xim, 3D-view

5.3.1.5

2xis, 3D-view

5.3.1.5

3gnx, 3D-view

5.3.1.5

4duo, 3D-view

5.3.1.5

5nh6, 3D-view

5.3.1.5

5xia, 3D-view

5.3.1.5

5y4j, 3D-view

5.3.1.5

7dfk, 3D-view

5.3.1.5

1s5n, 3D-view

5.3.1.5

1xig, 3D-view

5.3.1.5

1xim, 3D-view

5.3.1.5

1xin, 3D-view

5.3.1.5

1xlc, 3D-view

5.3.1.5

1xld, 3D-view

5.3.1.5

1xlg, 3D-view

5.3.1.5

1xlj, 3D-view

5.3.1.5

1xlm, 3D-view

5.3.1.5

2xim, 3D-view

5.3.1.5

2xis, 3D-view

5.3.1.5

3gnx, 3D-view

5.3.1.5

4duo, 3D-view

5.3.1.5

5nh6, 3D-view

5.3.1.5

5xia, 3D-view

5.3.1.5

5y4j, 3D-view

5.3.1.5

7dfk, 3D-view

5.3.1.5

1s5n, 3D-view

5.3.1.5

1xig, 3D-view

5.3.1.5

1xim, 3D-view

5.3.1.5

1xin, 3D-view

5.3.1.5

1xlc, 3D-view

5.3.1.5

1xld, 3D-view

5.3.1.5

1xlg, 3D-view

5.3.1.5

1xlj, 3D-view

5.3.1.5

1xlm, 3D-view

5.3.1.5

2xim, 3D-view

5.3.1.5

2xis, 3D-view

5.3.1.5

3gnx, 3D-view

5.3.1.5

4duo, 3D-view

5.3.1.5

5nh6, 3D-view

5.3.1.5

5xia, 3D-view

5.3.1.5

5y4j, 3D-view

5.3.1.5

7dfk, 3D-view

5.3.1.5

51 entries

5.4.99.9

3mj4, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (50 results)

top print hide

Show Turnover Number (50 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.1.1.10

0.6

-

pH 7.0, 25°C

656049

1.1.1.10

1

-

pH 7.0, 30°C, recombinant enzyme

721689

1.1.1.10

2

8

pH 7.0, 25°C

656049

1.1.1.10

5.6

-

-

684552

1.1.1.10

10

-

pH 7.0, 25°C

656049

1.1.1.10

17

-

pH 7.0, 25°C

656049

1.1.1.10

20

-

pH 7.0, 25°C

656049

1.1.1.11

177.2

-

-

701082

1.1.1.11

177.2

-

pH 8.5, 25°C

701082

1.1.1.12

3.25

-

pH 9, 30°C

711121

1.1.1.12

15

-

pH 8.0, 25°C

684627

1.1.1.12

18

-

pH 7.0, 30°C, native enzyme

761551

1.1.1.12

19.67

-

wild-type, pH 9.6, 20°C

696988

1.1.1.12

36.8

-

mutant Y318F, pH 9.6, 20°C

696988

1.1.1.12

1180

-

wild-type

696988

1.1.1.12

2208

-

mutant Y318F

696988

1.1.1.10

7 entries

1.1.1.11

2 entries

1.1.1.12

7 entries

1.1.1.14

0.63

-

wild-type, pH 10.0

686021

1.1.1.250

11.2

-

85°C, pH 8.5, Strep-tagged enzyme

746873

1.1.1.250

11.2

-

pH 8.5, 85°C, recombinant Strep-tagged enzyme

721370

1.1.1.250

16.6

-

85°C, pH 8.5, tag-less enzyme

746873

1.1.1.250

16.6

-

pH 8.5, 85°C, recombinant detagged enzyme

721370

1.1.1.250

4 entries

1.1.1.287

177.2

-

pH 8.5, 25°C

701082

1.1.1.307

0.87

-

pH 7, 25°C

286260

1.1.1.430

0.92

-

pH 7.0, 25°C

696196

1.1.1.431

0.6

-

pH 7, 25°C

764945

1.1.1.56

36

-

-

287120

1.1.1.9

1.12

-

recombinant enzyme, pH 7.0, 30°C

738728

1.1.1.9

2

3.7

recombinant mutant D205A/I206R, pH 9.0, 35°C, with NAD+

742112

1.1.1.9

11.1

-

recombinant wild-type enzyme, pH 9.0, 35°C, with NAD+

742112

1.1.1.9

13.28

-

pH 7.0, 30°C, recombinant enzyme

761562

1.1.1.9

15.015

-

pH 7.0, 30°C, recombinant enzyme

761562

1.1.1.9

17.9

-

pH 7.0, cofactor: NADP+mutant enzyme D38S/M39R

670911

1.1.1.9

18

-

at pH 7.0 and 30°C

738728

1.1.1.9

18

-

pH 7.0, 30°C, native enzyme

761551

1.1.1.9

19.62

-

pH 7.0, 30°C, recombinant enzyme

761562

1.1.1.9

19.7

-

recombinant mutant D205A, pH 9.0, 35°C, with NAD+

742112

1.1.1.9

24.6

-

pH 7.0, cofactor: NAD+, wild-type enzyme

670911

1.1.1.9

143

-

25°C, pH 7.5, Tris-HCl

655221

1.1.1.9

170

-

25°C, pH 7.5, potassium phosphate

655221

1.1.1.9

2115

-

35°C, pH 7.5, recombinant enzyme

667227

1.1.1.9

2644

-

35°C, pH 7.5, native enzyme

667227

1.1.1.9

15 entries

1.1.1.B19

2.75

-

pH 10.0, 40°C

711517

1.1.3.4

13

-

pH 7.5, 30°C

695424

1.1.3.41

1.9

-

pH 7.5, 25°C, recombinant enzyme

724072

1.1.3.41

9.1

12.2

recombinant oxidase-peroxidase fusion mutant enzyme, pH 7.5, temperature not specified in the publication

724756

1.1.3.41

13

-

in 50 mM sodium phosphate buffer, at pH 7.5 and 30°C

695424

1.1.3.41

13

-

pH 7.5, 25°C, recombinant enzyme

724072

1.1.3.41

13

-

pH 7.5, 30°C

695424

1.1.3.41

5 entries

1.1.5.2

15

-

pH 7.5, 70°C, wild-type enzyme

746918

2.7.1.17

237

-

wild type enzyme

675423

K_M Value (121 results)

top print hide

Show KM Value (121 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.1.10

0.0099

-

pH 7.0, 25°C, mutant Y149F

655222

1.1.1.10

0.011

-

pH 7.0, 25°C, wild-type enzyme

655222

1.1.1.10

0.013

-

pH 7.0, 25°C, mutant S136A

655222

1.1.1.10

0.085

-

pH 7.0, 25°C, mutant K153M

655222

1.1.1.10

7.2

-

pH 9.0, 30°C, purified recombinant enzyme

656206

1.1.1.10

10

-

pH 7.0, 25°C

656049

1.1.1.10

11

-

pH 7.0, 25°C

656049

1.1.1.10

15

-

pH 7.0, 25°C

656049

1.1.1.10

25

-

pH 7.0, 25°C

656049

1.1.1.10

40

-

pH 7.0, 25°C

656049

1.1.1.10

48

-

-

285658

1.1.1.10

72

-

-

246420

1.1.1.10

100

-

pH 7.0, 30°C, recombinant enzyme

721689

1.1.1.10

225

-

pH 9.6, 25°C, recombinant enzyme

760730

1.1.1.10

253

-

pH 9.6, 25°C, native enzyme

760730

1.1.1.10

925

-

-

285665

1.1.1.10

1239

-

-

684552

1.1.1.11

18.5

-

-

701082

1.1.1.11

177.2

-

pH 8.5, 25°C

701082

1.1.1.12

0.218

-

mutant Y318F

696988

1.1.1.12

0.218

-

mutant Y318F, pH 9.6, 20°C

696988

1.1.1.12

0.25

-

wild-type

696988

1.1.1.12

0.25

-

wild-type, pH 9.6, 20°C

696988

1.1.1.12

16

-

pH 7.0, 30°C, recombinant enzyme

761551

1.1.1.12

16.1

-

pH 7.0, 30°C, native enzyme

761551

1.1.1.12

23.3

-

pH 9, 30°C

711121

1.1.1.12

290

-

pH 8.0, 25°C

684627

1.1.1.14

0.17

-

wild-type, pH 10.0

686021

1.1.1.14

0.18

-

-

285880

1.1.1.14

0.4

-

-

285879

1.1.1.14

3.2

-

-

285895

1.1.1.14

14

-

-

285887

1.1.1.14

26

-

-

285884

1.1.1.14

37

-

-

285874

1.1.1.21

179.5

-

in 50 mM sodium phosphate at pH 7.0 and 30°C

700796

1.1.1.21

530

-

-

286249

1.1.1.250

20

-

85°C, pH 8.5, Strep-tagged enzyme

746873

1.1.1.250

20

-

pH 8.5, 85°C, recombinant Strep-tagged enzyme

721370

1.1.1.250

21.7

-

85°C, pH 8.5, tag-less enzyme

746873

1.1.1.250

21.7

-

pH 8.5, 85°C, recombinant detagged enzyme

721370

1.1.1.10

17 entries

1.1.1.11

2 entries

1.1.1.12

8 entries

1.1.1.14

7 entries

1.1.1.21

2 entries

1.1.1.250

4 entries

1.1.1.287

18.5

-

pH 8.5, 25°C

701082

1.1.1.307

0.8

-

cosubstrate NADP+, pH 7, 25°C

764945

1.1.1.307

0.9

-

cosubstrate NAD+, pH 7, 25°C

764945

1.1.1.307

257

-

pH 7, 25°C

286260

1.1.1.430

209

-

pH 7.0, 25°C

696196

1.1.1.430

326.3

-

pH 6.0

695731

1.1.1.431

334

-

pH 7.0, 25°C, wild-type enzyme

696083

1.1.1.431

480

-

pH 7, 25°C

764945

1.1.1.431

537

-

pH 7.0, 25°C, mutant enzyme D50A

696083

1.1.1.56

77

-

pH 9, 30°C

287125

1.1.1.56

273

-

pH 9, 30°C

287126

1.1.1.56

579

-

pH 7

287120

1.1.1.56

1000

-

pH 11

287121

1.1.1.9

0.039

-

-

684600

1.1.1.9

0.1

-

recombinant enzyme, pH 7.0, 30°C

738728

1.1.1.9

0.11

-

native enzyme, pH 7.0, 30°C

738728

1.1.1.9

0.638

-

pH 9.0, 35°C, cofactor: NADP+, mutant enzyme D207A/I208R/F209T

669305

1.1.1.9

0.731

-

pH 9.0, 35°C, cofactor: NADP+, mutant enzyme D207A/I208R/F209Y

669305

1.1.1.9

0.897

-

pH 9.0, 35°C, cofactor: NADP+, mutant enzyme D207A/I208R/F209S

669305

1.1.1.9

1.04

-

pH 9.0, 35°C, cofactor: NADP+, mutant enzyme S96C/S99C/Y102C/D207A/I208R/F209S/N211R

669305

1.1.1.9

1.18

-

pH 9.0, 35°C, cofactor: NADP+, mutant enzyme S96C/S99C/Y102C/D207A/I208R/F209S

669305

1.1.1.9

1.38

-

pH 9.0, 35°C, cofactor: NADP+, mutant enzyme D207A/I208R/F209S/N211R

669305

1.1.1.9

4

-

35°C, pH 7.5, native enzyme

667227

1.1.1.9

4

5.4

pH 9.0, 35°C, cofactor: NAD+, mutant enzyme I208R/F209S

669305

1.1.1.9

5.2

-

35°C, pH 7.5, recombinant enzyme

667227

1.1.1.9

7.1

-

-

246420

1.1.1.9

7.83

-

native enzyme, at pH 7.0 and 30°C

737866

1.1.1.9

7.83

-

native enzyme, pH 9.0, 35°C, with NAD+

742112

1.1.1.9

9.56

-

pH 9.0, 35°C, cofactor: NADP+, mutant enzyme S96C/S99CY102C

669305

1.1.1.9

9.96

-

pH 9.0, 35°C, cofactor: NADP+, mutant enzyme D207A/F209S

669305

1.1.1.9

10.1

-

recombinant enzyme, at pH 7.0 and 30°C

737866

1.1.1.9

10.1

-

recombinant wild-type enzyme, pH 9.0, 35°C, with NAD+

742112

1.1.1.9

10.38

-

pH 7.0, 30°C, recombinant enzyme

761562

1.1.1.9

11

-

-

246421

1.1.1.9

12

-

pH 8.2, 22°C

656363

1.1.1.9

12.1

-

pH 9.5, 25°C

710975

1.1.1.9

12.6

-

-

246420

1.1.1.9

13.7

-

pH 7.0, cofactor: NAD+, wild-type enzyme

670911

1.1.1.9

15.4

-

recombinant enzyme, pH 7.0, 30°C

738728

1.1.1.9

16

-

native enzyme, pH 7.0, 30°C

738728

1.1.1.9

16

-

pH 7.0, 30°C, recombinant enzyme

761551

1.1.1.9

16.1

-

at pH 7.0 and 30°C

738728

1.1.1.9

16.1

-

pH 7.0, 30°C, native enzyme

761551

1.1.1.9

16.4

-

-

246420

1.1.1.9

17.64

-

pH 7.0, 30°C, recombinant enzyme

761562

1.1.1.9

18.5

-

-

246417

1.1.1.9

20.96

-

pH 7.0, 30°C, recombinant enzyme

761562

1.1.1.9

21.7

-

pH 9.0, 35°, cofactor: NAD+, wild-type enzyme

669305

1.1.1.9

21.7

-

wild-type XDH: kcat/Km (NAD+): 2760 l/min/mmol, kcat/Km (NADP+): 2790 l/min/mmol

688749

1.1.1.9

22.2

-

pH 9.0, 35°C, cofactor: NAD+, mutant enzyme D207A

669305

1.1.1.9

24.2

-

pH 9.0, 35°C, cofactor: NAD+, mutant enzyme D207A/I208R

669305

1.1.1.9

25

-

-

246428

1.1.1.9

27.4

-

pH 9.0, 35°C, cofactor: NAD+, mutant enzyme N211R

669305

1.1.1.9

29.5

-

pH 9.0, 35°C, cofactor: NAD+, mutant enzyme I208R

669305

1.1.1.9

30.3

-

pH 9.0, 35°C, cofactor: NAD+, mutant enzyme S96C/S99CY102C

669305

1.1.1.9

31.1

-

mutant D207A/I208R/F209S: kcat/Km (NAD+): 181 l/min/mmol, kcat/Km (NADP+): 0.65 l/min/mmol

688749

1.1.1.9

34.1

-

pH 9.0, 35°C, cofactor: NAD+, mutant enzyme F209S

669305

1.1.1.9

45.2

-

pH 9.0, 35°C, cofactor: NAD+, mutant enzyme D207A/F209S

669305

1.1.1.9

49.8

-

-

246426

1.1.1.9

50.1

-

pH 9.0, 35°C, cofactor: NAD+, mutant enzyme D207A/I208R/F209Y

669305

1.1.1.9

55.7

-

pH 9.0, 35°C, cofactor: NAD+, mutant enzyme D207A/I208R/F209S

669305

1.1.1.9

66.7

-

mutant enzyme D205A, with NAD+ as cosubstrate, at pH 7.0 and 30°C

737866

1.1.1.9

66.7

-

recombinant mutant D205A, pH 9.0, 35°C, with NAD+

742112

1.1.1.9

86

-

recombinant enzyme, pH 9.0, 35°C

761107

1.1.1.9

94

-

-

655092

1.1.1.9

97.8

-

pH 9.0, 35°C, cofactor: NAD+, mutant enzyme D207A/I208R/F209T

669305

1.1.1.9

100

-

pH 7.0, cofactor: NADP+ mutant enzyme D38S/M39R

670911

1.1.1.9

111

-

mutant S96C/S99C/Y102C/D207A/I208R/F209S: kcat/Km (NADP+): 10700 l/min/mmol

688749

1.1.1.9

130

-

mutant enzyme D205A/I206R, with NADP+ as cosubstrate, at pH 7.0 and 30°C

737866

1.1.1.9

175.5

-

at pH 7.0 and 30°C

738725

1.1.1.B19

2.06

-

pH 10.0, 40°C

711517

1.1.1.B19

18.71

-

recombinant enzyme, pH 11.0, 45°C

762303

1.1.1.307

3 entries

1.1.1.430

2 entries

1.1.1.431

3 entries

1.1.1.56

4 entries

1.1.1.9

57 entries

1.1.1.B19

2 entries

1.1.1.B64

130

-

recombinant mutant D205A/I206R, pH 9.0, 35°C, with NADP+

742112

1.1.3.4

0.32

-

pH 7.5, 30°C

695424

1.1.3.41

0.007

-

pH 7.5, 25°C, recombinant enzyme

724072

1.1.3.41

0.29

0.35

recombinant oxidase-peroxidase fusion mutant enzyme, pH 7.5, temperature not specified in the publication

724756

1.1.3.41

0.32

-

in 50 mM sodium phosphate buffer, at pH 7.5 and 30°C

695424

1.1.3.41

0.32

-

pH 7.5, 25°C, recombinant enzyme

724072

1.1.3.41

0.32

-

pH 7.5, 30°C

695424

1.1.3.41

5 entries

1.1.5.2

0.00009

-

pH 7.5, 70°C, wild-type enzyme

746918

2.7.1.17

127

-

wild type enzyme

675423

K_i Value (5 results)

top print hide

Show KI Value (5 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

5.3.1.5

4.6

-

60°C, pH 7, wild-type

651118

5.3.1.5

5.1

-

in 100 mM Tris-HCl buffer (pH 7.5), 10 mM MgCl2, at 30°C

713924

5.3.1.5

33.2

-

60°C, pH 7, mutant E372G/V379A

651118

5.3.1.5

68.7

-

60°C, pH 7, mutant E372G

651118

5.3.1.5

1174

-

60°C, pH 7, mutant E372G/F163L

651118

5.3.1.5

5 entries

References & Links

Literature References (204)

top print hide

Show Reference (204 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

2369

1092963

Mutarotase (aldose 1-epimerase) from kidney cortex

1975

Bailey, J.M.; Fishman, P.H.; Kusiak, J.W.; Mulhern, S.; Pentchev, P.G.

Methods Enzymol.

41

471-484

2685

-

Purification and crystallization of D-arabinose (L-fucose) isomerase from Aerobacter aerogenes by polyethylene glycol

1974

Izumori, K.; Yamanaka, K.

Agric. Biol. Chem.

38

267-273

2686

236476

D-Arabinose (L-fucose) isomerase from Aerobacter aerogenes

1975

Yamanaka, K.; Izumori, K.

Methods Enzymol.

41B

462-465

2718

5773448

Crystallization and properties of L-arabinose isomerase from Lactobacillus gayonii

1969

Nakamatu, T.; Yamanaka, K.

Biochim. Biophys. Acta

178

156-165

2720

-

Purification and properties of L-arabinose isomerase from Streptomyces sp.

1973

Yamanka, K.; Izumori, K.

Agric. Biol. Chem.

37

521-526

2731

-

Studies on the D-glucose-isomerizing enzyme from Bacillus coagulans, strain HN-68. Part V. Comparative study on the three activities of D-glucose, D-xylose and D-ribose isomerization of the crystalline enzyme

1970

Danno, G.

Agric. Biol. Chem.

34

1805-1814

2736

236477

D-Xylose isomerase from Lactobacillus brevis

1975

Yamanaka, K.

Methods Enzymol.

41B

466-471

2738

-

Purification and properties of D-xylose isomerase from Lactobacillus xylosus

1977

Yamanaka, K.; Takahara, N.

Agric. Biol. Chem.

41

1909-1915

2746

-

Catalytic properties of D-xylose isomerase from Streptomyces violaceoruber

1986

Callens, M.; Kersters-Hilderson, H.; van Opstal, O.; de Bruyne, C.K.

Enzyme Microb. Technol.

8

696-700

2751

-

Characterization of the purified extracellular D-xylose isomerase devoid of D-glucose isomerase from Chainia sp.

1990

Khire, J.M.; Lachke, A.H.; Srinivasan, M.C.; Vartak, H.G.

Appl. Biochem. Biotechnol.

23

41-52

2754

-

Isolation and characterization of a D-glucose/xylose isomerase from a new thermophilic strain Streptomyces sp. (PLC)

1995

Inyang, C.U.; Gebhart, U.; Obi, S.K.C.; Bisswanger, H.

Appl. Microbiol. Biotechnol.

43

632-638

2771

2769749

Structures of D-xylose isomerase from Arthrobacter strain B3728 containing the inhibitor xylitol and D-sorbitol at 2.5 A and 2.3 A resolution, respectively

1989

Henrick, K.; Collyer, C.A.; Blow, D.M.

J. Mol. Biol.

208

129-157

2772

2390219

Comparative kinetics of D-xylose and D-glucose isomerase activities of the D-xylose isomerase from Thermus aquaticus HB8

1990

Lehmacher, A.; Bisswanger, H.

Biol. Chem. Hoppe-Seyler

371

527-536

2773

1854338

D-Xylose (D-glucose) isomerase from Arthrobacter strain N.R.R.L. B3728

1991

Smith, C.A.; Rangarajan, M.; Hartley, B.S.

Biochem. J.

277

255-261

9566

8250887

Identification, purification, and characterization of a D-arabinitol-specific dehydrogenase from Candida tropicalis

1993

Quong, M.W.; Miyada, C.G.; Switchenko, A.C.; Goodman, T.C.

Biochem. Biophys. Res. Commun.

196

1323-1329

136315

4709621

Studies on hemicellulases IV. Purification and properties of the beta-xylosidase produced by Aspergillus niger van Tieghem

1973

Takenishi, S.; Tsujisaka, Y.; Fukumoto, J.

J. Biochem.

73

335-343

246414

13654257

A sensitive and stereospecific enzymatic assay for xylulose

1959

Hickman, J.; Ashwell, G.

J. Biol. Chem.

234

758-761

246415

13789254

Erythritol dehydrogenase from Aerobacter aerogenes

1961

Jakoby, W.B.; Fredericks, J.

Biochim. Biophys. Acta

48

26-32

246416

13692998

A new pathway of pentose metabolism

1960

Chiang, C.; Knight, S.G.

Biochem. Biophys. Res. Commun.

3

554-559

246417

-

Purification and properties of xylitol dehydrogenase from the xylose-fermenting yeast Candida shehatae

1990

Yang, V.W.; Jeffries, T.W.

Appl. Biochem. Biotechnol.

26

197-206

246418

16347161

Affinity purifications of aldose reductase and xylitol dehydrogenase from the xylose-fermenting yeast Pachysolen tannophilus

1986

Bolen, P.L.; Roth, K.A.; Freer, S.N.

Appl. Environ. Microbiol.

52

660-664

246419

8339

Chirality of xylitol-oxidizing enzymes from mammalian liver

1976

Alizade, M.A.; Brendel, K.; Gaede, K.

FEBS Lett.

67

41-44

246420

3886639

Inducible xylitol dehydrogenases in enteric bacteria

1985

Doten, R.C.; Mortlock, R.P.

J. Bacteriol.

162

845-848

246421

-

Purification and properties of D-xylulose reductase from Pachysolen tannophilus

1986

Morimoto, S.; Matsuo, M.; Azuma, K.; Sinskey, A.J.

J. Ferment. Technol.

64

219-225

246422

8504864

Dual relationships of xylitol and alcohol dehydrogenases in families of two protein types

1993

Persson, B.; Hallborn, J.; Walfridsson, M.; Hahn-Haegerdal, B.; Keraenen, S.; Penttilae, M.; Joernvall, H.

FEBS Lett.

324

9-14

246423

10957958

Effect of D-glucose on induction of xylose reductase and xylitol dehydrogenase in Candida tropicalis in the presence of NaCl

2000

Ikeuchi, T.; Kiritani, R.; Azuma, M.; Ooshima, H.

J. Basic Microbiol.

40

167-175

246424

9103975

Induction of aldose reductase and xylitol dehydrogenase activities in Candida tenuis CBS 4435

1997

Kern, M.; Haltrich, D.; Nidetzky, B.; Kulbe, K.D.

FEMS Microbiol. Lett.

149

31-37

246425

1482390

Induction and regulation of D-xylose catabolizing enzymes in Fusarium oxysporum

1992

Singh, A.; Schuegerl, K.

Biochem. Int.

28

481-488

246426

10779871

Development of a xylitol biosensor composed of xylitol dehydrogenase and diaphorase

2000

Takamizawa, K.; Uchida, S.; Hatsu, M.; Suzuki, T.; Kawai, K.

Can. J. Microbiol.

46

350-357

246427

1393828

Effect of nitrogen sources on oxidoreductive enzymes and ethanol production during D-xylose fermentation by Candida shehatae

1992

Palnitkar, S.; Lachke, A.

Can. J. Microbiol.

38

258-260

246428

10486580

Evidence that the gene YLR070c of Saccharomyces cerevisiae encodes a xylitol dehydrogenase

1999

Richard, P.; Toivari, M.H.; Penttilae, M.

FEBS Lett.

457

135-138

285658

2981816

Characterization of xylitol-utilizing mutants of Erwinia uredovora

1985

Doten, R.C.; Mortlock, R.P.

J. Bacteriol.

161

529-533

285663

13416220

The L-xylulose-xylitol enzyme and other polyol dehydrogenases of guinea pig liver mitochondria

1957

Hollmann, S.; Touster, O.

J. Biol. Chem.

225

87-102

285664

13357463

The reduction of L-xylulose to xylitol by guinea pig liver mitochondria

1954

Touster, O.; Reynolds, V.H.; Hutcheson, R.M.

J. Biol. Chem.

221

697-709

285665

-

Isolation and characterization of two xylitol dehydrogenases from Aspergillus niger

1994

Witteveen, C.F.B.; Weber, F.; Busink, R.; Visser, J.

Microbiology

140

1679-1685

285666

7883010

Amino acid substitutions in the yeast Pichia stipitis xylitol dehydrogenase coenzyme-binding domain affect the coenzyme specificity

1995

Metzger, M.H.; Hollenberg, C.P.

Eur. J. Biochem.

228

50-54

285753

7698655

Isolation, characterization and expression of the gene that encodes D-arabinitol dehydrogenase in Candida tropicalis

1995

Murray, J.S.; Wong, M.L.; Miyada, C.G.; Switchenko, A.C.; Goodman, T.C.; Wong, B.

Gene

155

123-128

285754

7483848

A short-chain dehydrogenase gene from Pichia stipitis having D-arabinitol dehydrogenase activity

1995

Hallborn, J.; Walfridsson, M.; Penttilae, M.; Keraenen, S.; Hahn-Haegerdal, B.

Yeast

11

839-847

285872

7144570

Sorbitol dehydrogenase from rat liver

1982

Leissing, N.; McGuinness, E.T.

Methods Enzymol.

89

135-140

285874

16660917

Detection and characterization of sorbitol dehydrogenase from apple callus tissue

1979

Negm, F.B.; Loescher, W.H.

Plant Physiol.

64

69-73

285876

667078

Rapid affinity purification and properties of rat liver sorbitol dehydrogenase

1978

Leissing, N.; Mc Guinness, E.T.

Biochim. Biophys. Acta

524

254-261

285879

16089

Partial purification and characterization of sorbitol dehydrogenase from rat brain

1977

Rehg, J.E.; Torack, R.M.

J. Neurochem.

28

655-660

285880

13914358

Polyol dehydrogenase

1962

Smith, M.G.

Biochem. J.

83

135-144

285881

13479132

Oxidation of polyhydric alcohols by the prostate gland and seminal vesicle

1957

Williams-Ashman, H.G.; Banks, J.; Wolfson, S.K.

Arch. Biochem. Biophys.

72

485-494

285882

-

Sorbitol metabolism in spermatozoa

1959

King, T.E.; Mann, T.

Proc. R. Soc. Lond. B Biol. Sci.

151

226-243

285883

-

Sorbitol dehydrogenase from horse liver: Purification, characterization and comparative properties

1981

Bailey, J.P.; Renz, C.; McGuinness, E.T.

Comp. Biochem. Physiol. B

69

909-914

285884

-

Purification and properties of the NAD+-xylitol-dehydrogenase from the yeast Pichia stipitis

1989

Rizzi, M.; Harwart, K.; Erlemann, P.; Bui-Thanh, N.A.; Dellweg, H.

J. Ferment. Bioeng.

67

20-24

285886

-

Sorbitol dehydrogenase from Pseudomonas sp.: Purification, characterization and application to quantitative determination of sorbitol

1991

Schneider, K.H.; Giffhorn, F.

Enzyme Microb. Technol.

13

332-337

285887

1460002

Sorbitol dehydrogenase from Bacillus subtilis, purification, characterization and gene cloning

1992

Ng, K.; Ye, R.; Wu, X.C.; Wong, S.L.

J. Biol. Chem.

267

24989-24994

285888

-

Purification and properties of NAD-dependent sorbitol dehydrogenase from apple fruit

1994

Yamaguchi, H.; Kanayama, Y.; Yamaki, S.

Plant Cell Physiol.

35

887-892

285890

7551049

Polyol metabolism of Rhodobacter sphaeroides: biochemical characterization of a short-chain sorbitol dehydrogenase

1995

Schauder, S.; Schneider, K.H.; Giffhorn, F.

Microbiology

141

1857-1863

285895

9143345

Sorbitol dehydrogenase from bovine lens: purification and properties

1997

Marini, I.; Bucchioni, L.; Borella, P.; Del Corso, A.; Mura, U.

Arch. Biochem. Biophys.

340

383-391

285897

27389646

Crystallization and properties of NAD-dependent D-sorbitol dehydrogenase from Gluconobacter suboxydans IFO 3257

1999

Adachi, O.; Toyama, H.; Theeragool, G.; Lotong, N.; Matsushita, K.

Biosci. Biotechnol. Biochem.

63

1589-1595

285899

10963448

Purification and characterization of NAD+-dependent sorbitol dehydrogenase from Japanese pear fruit

2000

Oura, Y.; Yamada, K.; Shiratake, K.; Yamaki, S.

Phytochemistry

54

567-572

285901

-

Characterization of D-sorbitol dehydrogenase involved in D-sorbitol production of a methanol yeast, Candida boidinii (Kloeckera sp.) No. 2201

1988

Vongsuvanlert, V.; Tani, Y.

Agric. Biol. Chem.

52

419-426

286221

1901806

Purification and characterization of human testis aldose and aldehyde reductase

1991

Tanimoto, T.; Ohta, M.; Tanaka, A.; Ikemoto, I.; Machida, T.

Int. J. Biochem.

23

421-428

286240

6815419

Aldose reductase from human tissues

1982

Wermuth, B.; von Wartburg, J.P.

Methods Enzymol.

89

181-186

286241

6814912

Purification and characterization of human-brain aldose reductase

1982

Wermuth, B.; Burgisser, H.; Bohren, K.; von Wartburg, J.P.

Eur. J. Biochem.

127

279-284

286244

4402695

Purification of alditol: NADP oxidoreductase from human placenta

1972

Clements, R.S.; Winegrad, A.I.

Biochem. Biophys. Res. Commun.

47

1473-1479

286245

6402510

Purification and characterization of two aldose reductase isoenzymes from rabbit muscle

1983

Cromlish, J.A.; Flynn, T.G.

J. Biol. Chem.

258

3416-3424

286247

14275148

Isolation and properties of lens aldose reductase

1965

Hayman, S.; Kinoshita, J.H.

J. Biol. Chem.

240

877-882

286248

4216364

Purification and properties of calf liver aldose reductase

1974

Attwood, M.A.; Doughty, C.C.

Biochim. Biophys. Acta

370

358-368

286249

4381350

Pentose metabolism in Candida utilis

1966

Scher, B.M.; Horecker, B.I.

Arch. Biochem. Biophys.

116

117-128

286250

6426471

Bovine lens aldehyde reductase (aldose reductase)

1984

Halder, A.B.; Crabbe, M.J.C.

Biochem. J.

219

33-39

286251

6391552

Purification and properties of low-KM aldehyde reductase from ox brain

1984

Ryle, C.M.; Dowling, T.G.; Tipton, K.F.

Biochim. Biophys. Acta

791

155-163

286255

12223702

Characterization and purification of an aldose from the acidophilic and thermophilic red algae Galdiera sulphuraria

1997

Gross, W.; Seipold, P.; Schnarrenberger, C.

Plant Physiol.

114

231-236

286258

11306077

Structural and functional properties of alsode xylose reductase from the D-xylose-metabolizing Candida tenuis

2001

Nidetzky, B.; Mayr, P.; Neuhauser, W.; Puchberger, M.

Chem. Biol. Interact.

130-132

583-595

286259

10681056

D-Xylose metabolism by Candida intermedia: isolation and characterization of two forms of aldose reductase with different coenzyme specificities

2000

Mayr, P.; Bruggler, K.; Kulbe, K.D.; Nidetzky, B.

J. Chromatogr.

737

195-202

286260

9307017

NAD(P)H-dependent aldose reductase from the xylose-assimilating yeast Candida tenuis

1997

Neuhauser, W.; Haltrich, D.; Kulbe, K.D.; Nidetzky, B.

Biochem. J.

326

683-692

287033

11306103

Molecular cloning, expression and tissue distribution of hamster diacetyl reductase. Identity with L-xylulose reductase

2001

Ishikura, S.; Isaji, T.; Usami, N.; Kitahara, K.; Nakagawa, J.; Hara, A.

Chem. Biol. Interact.

130-132

879-889

287115

3904726

Ribitol dehydrogenase of Klebsiella aerogenes. Sequence and properties of wild-type and mutant strains

1985

Dothie, J.M.; Giglio, J.R.; Moore, C.B.; Tayler, S.S.; Hartley, B.S.

Biochem. J.

230

569-578

287120

4376942

A comparison of wild-type and mutant ribitol dehydrogenases from Klebsiella aerogenes

1974

Burleigh, B.D.; Rigby, P.W.J.; Hartley, B.S.

Biochem. J.

143

341-352

287121

4618776

Ribitol dehydrogenase from Klebsiella aerogenes. Purification and subunit structure

1974

Taylor, S.S.; Rigby, P.W.J.; Hartley, B.S.

Biochem. J.

141

693-700

287123

-

Pentitol dehydrogenases of Aerobacter aerogenes

1966

Fossitt, D.D.; Wood, W.A.

Methods Enzymol.

9

180-184

287125

1527498

Pentitol metabolism of Rodobacter sphaeroides Si4: purification and characterization of a ribitol dehydrogenase

1992

Kahle, C.; Schneider, K.H.; Giffhorn, F.

J. Gen. Microbiol.

138

1277-1281

287126

-

Purification and characterization of a ribitol dehydrogenase from Enterobacter agglomerans strain 221e

1995

Muniruzzaman, S.; Kunisha, Y.; Ichiraku K.; Izumori, K.

J. Ferment. Bioeng.

79

496-498

389404

7551050

Enzyme evolution in Rhodobacter sphaeroides: Selection of a mutant expressing a new galactitol dehydrogenase and biochemical characterization of the enzyme

1995

Schneider, K.H.; Jäkel, G.; Hoffmann, R.; Giffhorn, F.

Microbiology

141

1865-1873

389406

6767702

Polyol metabolism by Rhizobium trifolii

1980

Primrose, S.B.; Ronson, C.W.

J. Bacteriol.

141

1109-1114

393371

2515679

Physico-chemical properties of Aspergillus flavus var. columnaris alpha-amylase

1989

Ali, F.S.; Abdel-Moneim, A.A.

Zentralbl. Mikrobiol.

144

615-621

440251

16232758

Isolation, characterization, and molecular cloning of a thermostable xylitol oxidase from Streptomyces sp. IKD472

2000

Yamashita, M.; Omura, H.; Okamoto, E.; Furuya, Y.; Yabuuchi, M.; Fukahi, K.; Murooka, Y.

J. Biosci. Bioeng.

89

350-360

488450

8569754

Regulation of glycogen synthase activation in isolated hepatocytes

1995

Pugazhenthi, S.; Khandelwal, R.L.

Mol. Cell. Biochem.

149-150

95-101

488677

-

Trihalo-trideoxy galactosucrose compounds

1985

Rathbone, E.B.; Hacking, A.J.; Cheetham, P.S.J.

UK Patent Application

GB21

45080 A

637847

-

Transglucosylation catalyzed by sucrose phosphorylase from Leuconostoc mesenteroides and production of glycosyl-xylitol

1992

Kitao, S.; Sekine, H.

Biosci. Biotechnol. Biochem.

56

2011-2014

640692

6730972

Evidence for presence of a xylitol phosphotransferase system in Streptococcus mutans OMZ 176

1984

Assev, S.; Rölla, G.

Acta Pathol. Microbiol. Immunol. Scand. B

92

89-92

645051

-

D-Xylulokinase

1966

Simpson, F.J.

Methods Enzymol.

9

454-458

646416

2993253

Characterization of a membrane-regulated sugar phosphate phosphohydrolase from Lactobacillus casei

1985

London, J.; Hausman, S.Z.; Thompson, J.

J. Bacteriol.

163

951-956

650507

15174310

The acetyl xylan esterase II gene from Penicillium purpurogenum is differentially expressed in several carbon sources, and tightly regulated by pH

2004

Chavez, R.; Schachter, K.; Navarro, C.; Peirano, A.; Bull, P.; Eyzaguirre, J.

Biol. Res.

37

107-113

651118

11784309

Cold adaptation of xylose isomerase from Thermus thermophilus through random PCR mutagenesis. Gene cloning and protein characterization

2002

Lonn, A.; Gardonyi, M.; van Zyl, W.; Hahn-Hagerdal, B.; Otero, R.C.

Eur. J. Biochem.

269

157-163

654231

12018283

Utilization of xylitol dehydrogenase in a combined microbial/enzymatic process for production of xylitol from D-glucose

2002

Mayer, G.; Kulbe, K.D.; Nidetzky, B.

Appl. Biochem. Biotechnol.

98-100

577-589

655053

12723607

Cloning of the xylitol dehydrogenase gene from Gluconobacter oxydans and improved production of xylitol from D-arabitol

2003

Sugiyama, M.; Suzuki, S.; Tonouchi, N.; Yokozeki, K.

Biosci. Biotechnol. Biochem.

67

584-591

655092

100148847

Purification and characterisation of NAD+-dependent xylitol dehydrogenase from Fusarium oxysporum.

2002

Panagiotou, G.; Kekos, D.; Macris, B.J.; Christakopoulos, P.

Biotechnol. Lett.

24

2089-2092

655221

12604239

Characterization of recombinant xylitol dehydrogenase from Galactocandida mastotermitis expressed in Escherichia coli

2003

Nidetzky, B.; Helmer, H.; Klimacek, M.; Lunzer, R.; Mayer, G.

Chem. Biol. Interact.

143-144

533-542

655222

12604240

Identification of amino acid residues involved in substrate recognition of L-xylulose reductase by site-directed mutagenesis

2003

Ishikura, S.; Isaji, T.; Usami, N.; Nakagawa, J.; El-Kabbani, O.; Hara, A.

Chem. Biol. Interact.

143-144

543-550

655390

14555469

D-xylose metabolism in Hypocrea jecorina: loss of the xylitol dehydrogenase step can be partially compensated for by lad1-encoded L-arabinitol-4-dehydrogenase

2003

Seiboth, B.; Hartl, L.; Pail, M.; Kubicek, C.P.

Eukaryot. Cell

2

867-875

655769

12617608

Synthesis of new glycosides by transglycosylation of N-acetylhexosaminidase from Serratia marcescens YS-1

2003

Kurakake, M.; Goto, T.; Ashiki, K.; Suenaga, Y.; Komaki, T.

J. Agric. Food Chem.

51

1701-1705

655894

12111747

Influence of pH on the xylose reductase activity of Candida guilliermondii during fed-batch xylitol bioproduction

2002

Godoy de Andrade Rodrigues, D.C.; Silverio da Silva, S.; Vitolo, M.

J. Basic Microbiol.

42

201-206

656049

11882650

Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney

2002

Nakagawa, J.; Ishikura, S.; Asami, J.; Isaji, T.; Usami, N.; Hara, A.; Sakurai, T.; Tsuritani, K.; Oda, K.; Takahashi, M.; Yoshimoto, M.; Otsuka, N.; Kitamura, K.

J. Biol. Chem.

277

17888-17891

656206

14736891

A novel NADH-linked L-xylulose reductase in the L-arabinose catabolic pathway of yeast

2004

Verho, R.; Putkonen, M.; Londesborough, J.; Penttilä, M.; Richard, P.

J. Biol. Chem.

279

14746-14751

656363

15177159

Optimized extraction by cetyl trimethyl ammonium bromide reversed micelles of xylose reductase and xylitol dehydrogenase from Candida guilliermondii homogenate

2004

Cortez, E.V.; Pessoa, A.Jr.; das Gracas de Almeida Felipe, M.; Roberto, I.C.; Vitolo, M.

J. Chromatogr. B

807

47-54

656741

14526534

The activity of xylose reductase and xylitol dehydrogenase in yeasts

2003

Yablochkova, E.N.; Bolotnikova, O.I.; Mikhailova, N.P.; Nemova, N.N.; Ginak, A.I.

Microbiology

72

414-417

657623

14740189

Physico-chemical and transglucosylation properties of recombinant sucrose phosphorylase from Bifidobacterium adolescentis DSM20083

2004

van den Broek, L.A.; van Boxtel, E.L.; Kievit, R.P.; Verhoef, R.; Beldman, G.; Voragen, A.G.

Appl. Microbiol. Biotechnol.

65

219-227

661142

15157080

Xylose isomerase in substrate and inhibitor michaelis states: atomic resolution studies of a metal-mediated hydride shift

2004

Fenn, T.D.; Ringe, D.; Petsko, G.A.

Biochemistry

43

6464-6474

662489

16084621

Purification and characterization of an L-arabinose isomerase from an isolated strain of Geobacillus thermodenitrificans producing D-tagatose

2005

Kim, H.J.; Oh, D.K.

J. Biotechnol.

120

162-173

667227

15803389

Characterization of the AXDH gene and the encoded xylitol dehydrogenase from the dimorphic yeast Arxula adeninivorans

2005

Böer, E.; Wartmann, T.; Schmidt, S.; Bode, R.; Gellissen, G.; Kunze, G.

Antonie van Leeuwenhoek

87

233-243

667268

16751533

Production of xylitol from D-xylose by a xylitol dehydrogenase gene-disrupted mutant of Candida tropicalis

2006

Ko, B.S.; Kim, J.; Kim, J.H.

Appl. Environ. Microbiol.

72

4207-4213

669305

15623532

Complete reversal of coenzyme specificity of xylitol dehydrogenase and increase of thermostability by the introduction of structural zinc

2005

Watanabe, S.; Kodaki, T.; Makino, K.

J. Biol. Chem.

280

10340-10349

669541

16310740

Cloning and expression of NAD+-dependent L-arabinitol 4-dehydrogenase gene (ladA) of Aspergillus oryzae

2005

Suzuki, T.; Tran, L.H.; Yogo, M.; Idota, O.; Kitamoto, N.; Kawai, K.; Takamizawa, K.

J. Biosci. Bioeng.

100

472-474

670513

16289145

Molecular evidence of sorbitol dehydrogenase in tomato, a non-Rosaceae plant

2005

Ohta, K.; Moriguchi, R.; Kanahama, K.; Yamaki, S.; Kanayama, Y.

Phytochemistry

66

2822-2828

670839

15906319

Structure of the tetrameric form of human L-xylulose reductase: probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis

2005

El-Kabbani, O.; Carbone, V.; Darmanin, C.; Ishikura, S.; Hara, A.

Proteins

60

424-432

670911

16531240

Structure-guided engineering of xylitol dehydrogenase cosubstrate specificity

2006

Ehrensberger, A.H.; Elling, R.A.; Wilson, D.K.

Structure

14

567-575

671399

16878542

Biosynthetic features and properties of xylose isomerases from Arthrobacter nicotianae, Escherichia coli, and Erwinia carotovora subsp. atroseptica

2006

Sapunova, L.I.; Lobanok, A.G.; Kazakevich, I.O.; Shlyakhotko, E.A.; Evtushenkov, A.N.

Appl. Biochem. Microbiol.

42

246-251

674223

16834601

Cloning and molecular characterization of a gene coding D-xylulokinase (CmXYL3) from Candida maltosa

2006

Guo, C.; He, P.; Lu, D.; Shen, A.; Jiang, N.

J. Appl. Microbiol.

101

139-150

674224

16834609

Characterization of a mutated Geobacillus stearothermophilus L-arabinose isomerase that increases the production rate of D-tagatose

2006

Kim, H.J.; Kim, J.H.; Oh, H.J.; Oh, D.K.

J. Appl. Microbiol.

101

213-221

675423

17123542

Structural and kinetic studies of induced fit in xylulose kinase from Escherichia coli

2007

Di Luccio, E.; Petschacher, B.; Voegtli, J.; Chou, H.T.; Stahlberg, H.; Nidetzky, B.; Wilson, D.K.

J. Mol. Biol.

365

783-798

677266

100100911

Purification and characterization of L-arabinose isomerase from Lactobacillus plantarum producing D-tagatose

2007

Zhang, H.; Jiang, B.; Pan, B.

World J. Microbiol. Biotechnol.

23

641-646

679550

-

Molecular cloning of a gene encoding the sucrose phosphorylase from Leuconostoc mesenteroides B-1149 and the expression in Escherichia coli

2006

Lee, J.; Yoon, S.; Nam, S.; Moon, Y.; Moon, Y.; Kim, D.

Enzyme Microb. Technol.

39

612-620

684552

17261518

Biochemical characterization of an L-Xylulose reductase from Neurospora crassa

2007

Nair, N.; Zhao, H.

Appl. Environ. Microbiol.

73

2001-2004

684600

17216457

A rare sugar xylitol. Part I: The biochemistry and biosynthesis of xylitol

2007

Granstroem, T.B.; Izumori, K.; Leisola, M.

Appl. Microbiol. Biotechnol.

74

277-281

684627

17938906

Cloning, characterization, and mutational analysis of a highly active and stable L-arabinitol 4-dehydrogenase from Neurospora crassa

2007

Sullivan, R.; Zhao, H.

Appl. Microbiol. Biotechnol.

77

845-852

684974

17343568

Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-Cys forms of yeast xylitol dehydrogenase

2007

Klimacek, M.; Hellmer, H.; Nidetzky, B.

Biochem. J.

404

421-429

686021

17952367

A hydrogen-bonding network in mammalian sorbitol dehydrogenase stabilizes the tetrameric state and is essential for the catalytic power

2007

Hellgren, M.; Kaiser, C.; de Haij, S.; Norberg, A.; Hoeoeg, J.O.

Cell. Mol. Life Sci.

64

3129-3138

686433

-

Production of L-xylulose from xylitol by a newly isolated strain of Bacillus pallidus Y25 and characterization of its relevant enzyme xylitol dehydrogenase

2007

Poonperm, W.; Takata, G.; Morimoto, K.; Granstroem, T.B.; Izumori, K.

Enzyme Microb. Technol.

40

1206-1212

687872

17350704

Thermostabilization of Pichia stipitis xylitol dehydrogenase by mutation of structural zinc-binding loop

2007

Annaluru, N.; Watanabe, S.; Pack, S.P.; Saleh, A.A.; Kodaki, T.; Makino, K.

J. Biotechnol.

129

717-722

688749

17651216

Effect of the reversal of coenzyme specificity by expression of mutated Pichia stipitis xylitol dehydrogenase in recombinant Saccharomyces cerevisiae

2007

Hou, J.; Shen, Y.; Li, X.P.; Bao, X.M.

Lett. Appl. Microbiol.

45

184-189

688820

18723107

Heterologous expression of d-xylulokinase from Pichia stipitis enables high levels of xylitol production by engineered Escherichia coli growing on xylose

2009

Akinterinwa, O.; Cirino, P.C.

Metab. Eng.

11

48-55

692116

-

Synthesis of novel disaccharides by a newly isolated fructosyl transferase from Bacillus subtilis

1989

Cheetham, P.S.; Hacking, A.J.; Vlitos, M.

Enzyme Microb. Technol.

11

212-219

695424

-

Exploring the biocatalytic scope of alditol oxidase from Streptomyces coelicolor

2009

Van Hellemond, E.; Vermote, L.; Koolen, W.; Sonke, T.; Zandvoort, E.; Heuts, D.; Janssen, D.; Fraaije, M.

Adv. Synth. Catal.

351

1523-1530

695731

14532079

Cloning and characterization of the xyl1 gene, encoding an NADH-preferring xylose reductase from Candida parapsilosis, and its functional expression in Candida tropicalis

2003

Lee, J.K.; Koo, B.S.; Kim, S.Y.

Appl. Environ. Microbiol.

69

6179-6188

695833

19224207

Export of functional Streptomyces coelicolor alditol oxidase to the periplasm or cell surface of Escherichia coli and its application in whole-cell biocatalysis

2009

van Bloois, E.; Winter, R.T.; Janssen, D.B.; Fraaije, M.W.

Appl. Microbiol. Biotechnol.

83

679-687

696083

16336198

Probing the substrate binding site of Candida tenuis xylose reductase (AKR2B5) with site-directed mutagenesis

2006

Kratzer, R.; Leitgeb, S.; Wilson, D.K.; Nidetzky, B.

Biochem. J.

393

51-58

696196

11513616

Transient-state and steady-state kinetic studies of the mechanism of NADH-dependent aldehyde reduction catalyzed by xylose reductase from the yeast Candida tenuis

2001

Nidetzky, B.; Klimacek, M.; Mayr, P.

Biochemistry

40

10371-10381

696889

19452479

Engineering of a matched pair of xylose reductase and xylitol dehydrogenase for xylose fermentation by Saccharomyces cerevisiae

2009

Krahulec, S.; Klimacek, M.; Nidetzky, B.

Biotechnol. J.

4

684-694

696988

19674460

A single amino acid change (Y318F) in the L-arabitol dehydrogenase (LadA) from Aspergillus niger results in a significant increase in affinity for D-sorbitol

2009

Rutten, L.; Ribot, C.; Trejo-Aguilar, B.; Woesten, H.A.; de Vries, R.P.

BMC Microbiol.

9

166

699148

-

Profiles of xylose reductase, xylitol dehydrogenase and xylitol production under different oxygen transfer volumetric coefficient values

2009

Branco, R.; dos Santos, J.; Sarrouh, B.; Rivaldi, J.; Pessoa Jr., A.; da Silva, S.

J. Chem. Technol. Biotechnol.

84

326-330

699368

18830730

The behavior of key enzymes of xylose metabolism on the xylitol production by Candida guilliermondii grown in hemicellulosic hydrolysate

2009

Gurpilhares, D.B.; Hasmann, F.A.; Pessoa, A.; Roberto, I.C.

J. Ind. Microbiol. Biotechnol.

36

87-93

700010

18346277

Altering the coenzyme preference of xylose reductase to favor utilization of NADH enhances ethanol yield from xylose in a metabolically engineered strain of Saccharomyces cerevisiae

2008

Petschacher, B.; Nidetzky, B.

Microb. Cell Fact.

7

9

700796

19056286

Structural and kinetic characterization of a maize aldose reductase

2009

de Sousa, S.M.; Rosselli, L.K.; Kiyota, E.; da Silva, J.C.; Souza, G.H.; Peroni, L.A.; Stach-Machado, D.R.; Eberlin, M.N.; Souza, A.P.; Koch, K.E.; Arruda, P.; Torriani, I.L.; Yunes, J.A.

Plant Physiol. Biochem.

47

98-104

701080

19020964

Influence of polyols on the stability and kinetic parameters of invertase from Candida utilis: correlation with the conformational stability and activity

2008

Gangadhara, A.R.; Ramesh Kumar, P.; Prakash, V.

Protein J.

27

440-449

701082

19629658

Cloning, purification and characterization of an NAD-dependent D-arabitol dehydrogenase from acetic acid bacterium, Acetobacter suboxydans

2009

Cheng, H.; Li, Z.; Jiang, N.; Deng, Z.

Protein J.

28

263-272

701788

19218403

Functional expression of a bacterial xylose isomerase in Saccharomyces cerevisiae

2009

Brat, D.; Boles, E.; Wiedemann, B.

Appl. Environ. Microbiol.

75

2304-2311

710975

20177886

Cloning and characterization of a thermostable xylitol dehydrogenase from Rhizobium etli CFN42

2010

Tiwari, M.K.; Moon, H.J.; Jeya, M.; Lee, J.K.

Appl. Microbiol. Biotechnol.

87

571-581

711121

20111899

Cloning, heterologous expression, and characterization of the xylitol and L-arabitol dehydrogenase genes, Texdh and Telad, from the thermophilic fungus Talaromyces emersonii

2010

Fernandes, S.; Tuohy, M.G.; Murray, P.G.

Biochem. Genet.

48

480-495

711517

20834176

Cloning and overexpression of the xylitol dehydrogenase gene from Bacillus pallidus and its application to L-xylulose production

2010

Takata, G.; Poonperm, W.; Morimoto, K.; Izumori, K.

Biosci. Biotechnol. Biochem.

74

1807-1813

712439

20410293

Structural insight into substrate differentiation of the sugar-metabolizing enzyme galactitol dehydrogenase from Rhodobacter sphaeroides D

2010

Carius, Y.; Christian, H.; Faust, A.; Zander, U.; Klink, B.U.; Kornberger, P.; Kohring, G.W.; Giffhorn, F.; Scheidig, A.J.

J. Biol. Chem.

285

20006-20014

712767

20655316

Structure and engineering of L-arabinitol 4-dehydrogenase from Neurospora crassa

2010

Bae, B.; Sullivan, R.P.; Zhao, H.; Nair, S.K.

J. Mol. Biol.

402

230-240

713924

21655987

Xylitol does not inhibit xylose fermentation by engineered Saccharomyces cerevisiae expressing xylA as severely as it inhibits xylose isomerase reaction in vitro

2011

Ha, S.J.; Kim, S.R.; Choi, J.H.; Park, M.S.; Jin, Y.S.

Appl. Microbiol. Biotechnol.

92

77-84

721343

20889775

Increased ethanol productivity in xylose-utilizing Saccharomyces cerevisiae via a randomly mutagenized xylose reductase

2010

Runquist, D.; Hahn-Haegerdal, B.; Bettiga, M.

Appl. Environ. Microbiol.

76

7796-7802

721370

21347726

Properties of recombinant Strep-tagged and untagged hyperthermophilic D-arabitol dehydrogenase from Thermotoga maritima

2011

Kallnik, V.; Schulz, C.; Schultz, C.; Schweiger, P.; Deppenmeier, U.

Appl. Microbiol. Biotechnol.

90

1285-1293

721689

23506391

A novel L-xylulose reductase essential for L-arabinose catabolism in Trichoderma reesei

2013

Metz, B.; Mojzita, D.; Herold, S.; Kubicek, C.P.; Richard, P.; Seiboth, B.

Biochemistry

52

2453-2460

721848

21922311

Xylitol production is increased by expression of codon-optimized Neurospora crassa xylose reductase gene in Candida tropicalis

2012

Jeon, W.Y.; Yoon, B.H.; Ko, B.S.; Shim, W.Y.; Kim, J.H.

Bioprocess Biosyst. Eng.

35

191-198

721913

23436125

NAD+-dependent xylitol dehydrogenase (xdhA) and L-arabitol-4-dehydrogenase (ladA) deletion mutants of Aspergillus oryzae for improved xylitol production

2013

Mahmud, A.; Hattori, K.; Hongwen, C.; Kitamoto, N.; Suzuki, T.; Nakamura, K.; Takamizawa, K.

Biotechnol. Lett.

35

769-777

722304

23398717

Feasibility of xylose fermentation by engineered Saccharomyces cerevisiae overexpressing endogenous aldose reductase (GRE3), xylitol dehydrogenase (XYL2) and xylulokinase (XYL3) from Scheffersomyces stipitis

2013

Kim, S.R.; Kwee, N.R.; Kim, H.; Jin, Y.S.

FEMS Yeast Res.

13

312-321

722437

-

Purification of xylitol dehydrogenase and improved production of xylitol by increasing XDH activity and NADH supply in Gluconobacter oxydans

2013

Zhang, J.; Li, S.; Xu, H.; Zhou, P.; Zhang, L.; Ouyang, P.

J. Agric. Food Chem.

61

2861-2867

722851

21903144

Analysis and prediction of the physiological effects of altered coenzyme specificity in xylose reductase and xylitol dehydrogenase during xylose fermentation by Saccharomyces cerevisiae

2012

Krahulec, S.; Klimacek, M.; Nidetzky, B.

J. Biotechnol.

158

192-202

724072

22231860

Hot or not? Discovery and characterization of a thermostable alditol oxidase from Acidothermus cellulolyticus 11B

2012

Winter, R.T.; Heuts, D.P.; Rijpkema, E.M.; van Bloois, E.; Wijma, H.J.; Fraaije, M.W.

Appl. Microbiol. Biotechnol.

95

389-403

724644

22918792

Development of a substrate-coupled biocatalytic process driven by an NADPH-dependent sorbose reductase from Candida albicans for the asymmetric reduction of ethyl 4-chloro-3-oxobutanoate

2012

Cai, P.; An, M.; Xu, L.; Xu, S.; Hao, N.; Li, Y.; Guo, K.; Yan, M.

Biotechnol. Lett.

34

2223-2227

724756

22213198

Functionalization of oxidases with peroxidase activity creates oxiperoxidases: a new breed of hybrid enzyme capable of cascade chemistry

2012

Winter, R.T.; van den Berg, T.E.; Colpa, D.I.; van Bloois, E.; Fraaije, M.W.

ChemBioChem

13

252-258

726893

-

Characterization of a thermophilic L-arabinose isomerase from Thermoanaerobacterium saccharolyticum NTOU1

2014

Hung, X.; Tseng, W.; Liu, S.; Tzou, W.; Fang, T.

Biochem. Eng. J.

83

121-128

730719

23349732

Structural basis of the gamma-lactone-ring formation in ascorbic acid biosynthesis by the senescence marker protein-30/gluconolactonase

2013

Aizawa, S.; Senda, M.; Harada, A.; Maruyama, N.; Ishida, T.; Aigaki, T.; Ishigami, A.; Senda, T.

PLoS ONE

8

e53706

736022

22883556

Protein engineering of a thermostable polyol dehydrogenase

2012

Wulf, H.; Mallin, H.; Bornscheuer, U.

Enzyme Microb. Technol.

51

217-224

737866

25082263

Molecular analysis of NAD+-dependent xylitol dehydrogenase from the zygomycetous fungus Rhizomucor pusillus and reversal of the coenzyme preference

2014

Yamasaki-Yashiki, S.; Komeda, H.; Hoshino, K.; Asano, Y.

Biosci. Biotechnol. Biochem.

78

1943-1953

737895

27245615

Effects of xylitol dehydrogenase (XYL2) on xylose fermentation by engineered Candida glycerinogenes

2017

Zong, H.; Zhang, C.; Zhuge, B.; Lu, X.; Fang, H.; Sun, J.

Biotechnol. Appl. Biochem.

64

590-599

738725

26975753

Enhanced xylitol production: Expression of xylitol dehydrogenase from Gluconobacter oxydans and mixed culture of resting cell

2016

Qi, X.H.; Zhu, J.F.; Yun, J.H.; Lin, J.; Qi, Y.L.; Guo, Q.; Xu, H.

J. Biosci. Bioeng.

122

257-262

738728

27506274

Purification and characterization of xylitol dehydrogenase with L-arabitol dehydrogenase activity from the newly isolated pentose-fermenting yeast Meyerozyma caribbica 5XY2

2016

Sukpipat, W.; Komeda, H.; Prasertsan, P.; Asano, Y.

J. Biosci. Bioeng.

123

20-27

738796

24570325

Point mutation of the xylose reductase (XR) gene reduces xylitol accumulation and increases citric acid production in Aspergillus carbonarius

2014

Weyda, I.; Luebeck, M.; Ahring, B.K.; Luebeck, P.S.

J. Ind. Microbiol. Biotechnol.

41

733-739

738797

25363139

Integrative expression vectors for overexpression of xylitol dehydrogenase (XYL2) in osmotolerant yeast, Candida glycerinogenes WL2002-5

2015

Zhang, C.; Zong, H.; Zhuge, B.; Lu, X.; Fang, H.; Zhuge, J.

J. Ind. Microbiol. Biotechnol.

42

113-124

740206

25342968

Induction of D-xylose uptake and expression of NAD(P)H-linked xylose reductase and NADP+-linked xylitol dehydrogenase in the oleaginous microalga Chlorella sorokiniana

2014

Zheng, Y.; Yu, X.; Li, T.; Xiong, X.; Chen, S.

Biotechnol. Biofuels

7

125

740390

24731824

Cloning and characterization of a galactitol 2-dehydrogenase from Rhizobium legumenosarum and its application in D-tagatose production

2014

Jagtap, S.S.; Singh, R.; Kang, Y.C.; Zhao, H.; Lee, J.K.

Enzyme Microb. Technol.

58-59

44-51

740457

28144940

Production of alkenes and novel secondary products by P450 OleTJE using novel H2O2-generating fusion protein systems

2017

Matthews, S.; Tee, K.L.; Rattray, N.J.; McLean, K.J.; Leys, D.; Parker, D.A.; Blankley, R.T.; Munro, A.W.

FEBS Lett.

591

737-750

740772

23287496

Xylitol production by NAD+-dependent xylitol dehydrogenase (xdhA)- and L-arabitol-4-dehydrogenase (ladA)-disrupted mutants of Aspergillus oryzae

2013

Mahmud, A.; Hattori, K.; Hongwen, C.; Kitamoto, N.; Suzuki, T.; Nakamura, K.; Takamizawa, K.

J. Biosci. Bioeng.

115

353-359

740782

23578809

Boost in bioethanol production using recombinant Saccharomyces cerevisiae with mutated strictly NADPH-dependent xylose reductase and NADP+-dependent xylitol dehydrogenase

2013

Khattab, S.M.; Saimura, M.; Kodaki, T.

J. Biotechnol.

165

153-156

741374

26440996

Crystal structure of quinone-dependent alcohol dehydrogenase from Pseudogluconobacter saccharoketogenes. A versatile dehydrogenase oxidizing alcohols and carbohydrates

2015

Rozeboom, H.J.; Yu, S.; Mikkelsen, R.; Nikolaev, I.; Mulder, H.J.; Dijkstra, B.W.

Protein Sci.

24

2044-2054

742112

25082263

Molecular analysis of NAD+-dependent xylitol dehydrogenase from the zygomycetous fungus Rhizomucor pusillus and reversal of the coenzyme preference

2014

Yamasaki-Yashiki, S.; Komeda, H.; Hoshino, K.; Asano, Y.

Biosci. Biotechnol. Biochem.

78

1943-1953

742151

25342968

Induction of D-xylose uptake and expression of NAD(P)H-linked xylose reductase and NADP+-linked xylitol dehydrogenase in the oleaginous microalga Chlorella sorokiniana

2014

Zheng, Y.; Yu, X.; Li, T.; Xiong, X.; Chen, S.

Biotechnol. Biofuels

7

125-132

742720

23432201

Purification of xylitol dehydrogenase and improved production of xylitol by increasing XDH activity and NADH supply in Gluconobacter oxydans

2013

Zhang, J.; Li, S.; Xu, H.; Zhou, P.; Zhang, L.; Ouyang, P.

J. Agric. Food Chem.

61

2861-2867

742925

23287496

Xylitol production by NAD+-dependent xylitol dehydrogenase (xdhA)- and L-arabitol-4-dehydrogenase (ladA)-disrupted mutants of Aspergillus oryzae

2013

Mahmud, A.; Hattori, K.; Hongwen, C.; Kitamoto, N.; Suzuki, T.; Nakamura, K.; Takamizawa, K.

J. Biosci. Bioeng.

115

353-359

742937

26975753

Enhanced xylitol production expression of xylitol dehydrogenase from Gluconobacter oxydans and mixed culture of resting cell

2016

Qi, X.H.; Zhu, J.F.; Yun, J.H.; Lin, J.; Qi, Y.L.; Guo, Q.; Xu, H.

J. Biosci. Bioeng.

122

257-262

742941

28126230

Analysis of metabolisms and transports of xylitol using xylose- and xylitol-assimilating Saccharomyces cerevisiae

2017

Tani, T.; Taguchi, H.; Akamatsu, T.

J. Biosci. Bioeng.

123

613-620

743029

24570325

Point mutation of the xylose reductase (XR) gene reduces xylitol accumulation and increases citric acid production in Aspergillus carbonarius

2014

Weyda, I.; Luebeck, M.; Ahring, B.K.; Luebeck, P.S.

J. Ind. Microbiol. Biotechnol.

41

733-739

743034

28070721

Enhanced xylose fermentation by engineered yeast expressing NADH oxidase through high cell density inoculums

2017

Zhang, G.C.; Turner, T.L.; Jin, Y.S.

J. Ind. Microbiol. Biotechnol.

44

387-395

746873

21347726

Properties of recombinant Strep-tagged and untagged hyperthermophilic D-arabitol dehydrogenase from Thermotoga maritima

2011

Kallnik, V.; Schultz, C.; Schweiger, P.; Deppenmeier, U.

Appl. Microbiol. Biotechnol.

90

1285-1293

746918

27592307

Biochemical and structural characterization of quinoprotein aldose sugar dehydrogenase from Thermus thermophilus HJ6 Mutational analysis of Tyr156 in the substrate-binding site

2016

Kim, H.; Wang, J.; Lee, J.; Park, A.; Park, H.; Jeon, S.

Arch. Biochem. Biophys.

608

20-26

751231

29624688

Characteristics of an beta-N-acetylhexosaminidase from Bacillus sp. CH11, including its transglycosylation activity

2018

Kurakake, M.; Amai, Y.; Konishi, M.; Ikehira, K.

J. Food Sci.

83

1208-1214

760272

31552350

Identification of NAD-dependent xylitol dehydrogenase from Gluconobacter oxydans WSH-003

2019

Liu, L.; Zeng, W.; Du, G.; Chen, J.; Zhou, J.

ACS omega

4

15074-15080

760329

31599368

Systematic improvement of isobutanol production from D-xylose in engineered Saccharomyces cerevisiae

2019

Promdonkoy, P.; Siripong, W.; Downes, J.J.; Tanapongpipat, S.; Runguphan, W.

AMB Express

9

160

760367

30175383

Efficient biosynthesis of xylitol from xylose by coexpression of xylose reductase and glucose dehydrogenase in Escherichia coli

2019

Jin, L.Q.; Xu, W.; Yang, B.; Liu, Z.Q.; Zheng, Y.G.

Appl. Biochem. Biotechnol.

187

1143-1157

760713

28364633

Improved xylitol production by expressing a novel D-arabitol dehydrogenase from isolated Gluconobacter sp. JX-05 and co-biotransformation of whole cells

2017

Qi, X.; Zhang, H.; Magocha, T.A.; An, Y.; Yun, J.; Yang, M.; Xue, Y.; Liang, S.; Sun, W.; Cao, Z.

Biores. Technol.

235

50-58

760714

28550778

Construction of efficient xylose-fermenting Saccharomyces cerevisiae through a synthetic isozyme system of xylose reductase from Scheffersomyces stipitis

2017

Jo, J.H.; Park, Y.C.; Jin, Y.S.; Seo, J.H.

Biores. Technol.

241

88-94

760720

30831517

A unique xylose reductase from Thermomyces lanuginosus effect of lignocellulosic substrates and inhibitors and applicability in lignocellulosic bioconversion

2019

Zhang, M.; Puri, A.K.; Wang, Z.; Singh, S.; Permaul, K.

Biores. Technol.

281

374-381

760730

28471330

Characterization and gene cloning of L-xylulose reductase involved in L-arabinose catabolism from the pentose-fermenting fungus Rhizomucor pusillus

2017

Yamasaki-Yashiki, S.; Komeda, H.; Hoshino, K.; Asano, Y.

Biosci. Biotechnol. Biochem.

81

1612-1618

760758

30705706

Xylose fermentation efficiency of industrial Saccharomyces cerevisiae yeast with separate or combined xylose reductase/xylitol dehydrogenase and xylose isomerase pathways

2019

Cunha, J.T.; Soares, P.O.; Romani, A.; Thevelein, J.M.; Domingues, L.

Biotechnol. Biofuels

12

20

760875

-

Xylose enhances furfural tolerance in Candida tropicalis by improving NADH recycle

2017

Wang, S.; He, Z.; Yuan, Q.

Chem. Eng. Sci.

158

37-40

761105

31073598

Physiological and comparative genomic analysis of new isolated yeasts Spathaspora sp. JA1 and Meyerozyma caribbica JA9 reveal insights into xylitol production

2019

Trichez, D.; Steindorff, A.S.; Soares, C.E.V.F.; Formighieri, E.F.; Almeida, J.R.M.

FEMS Yeast Res.

19

foz034

761107

-

Combining xylose reductase from Spathaspora arborariae with xylitol dehydrogenase from Spathaspora passalidarum to promote xylose consumption and fermentation into xylitol by Saccharomyces cerevisiae

2020

Mouro, A.; Santos, A.; Agnolo, D.; Gubert, G.; Bon, E.; Rosa, C.; Fonseca, C.; Stambuk, B.

Fermentation

6

72

761551

27506274

Purification and characterization of xylitol dehydrogenase with L-arabitol dehydrogenase activity from the newly isolated pentose-fermenting yeast Meyerozyma caribbica 5XY2

2017

Sukpipat, W.; Komeda, H.; Prasertsan, P.; Asano, Y.

J. Biosci. Bioeng.

123

20-27

761562

32171656

Cloning and functional characterization of xylitol dehydrogenase genes from Issatchenkia orientalis and Torulaspora delbrueckii

2020

Han, X.; Hu, X.; Zhou, C.; Wang, H.; Li, Q.; Ouyang, Y.; Kuang, X.; Xiao, D.; Xiang, Q.; Yu, X.; Li, X.; Gu, Y.; Zhao, K.; Chen, Q.; Ma, M.

J. Biosci. Bioeng.

130

29-35

761563

27297548

Formation of xylitol and xylitol-5-phosphate and its impact on growth of D-xylose-utilizing Corynebacterium glutamicum strains

2016

Radek, A.; Mueller, M.F.; Gaetgens, J.; Eggeling, L.; Krumbach, K.; Marienhagen, J.; Noack, S.

J. Biotechnol.

231

160-166

761647

31025135

Efficient production of xylitol by the integration of multiple copies of xylose reductase gene and the deletion of Embden-Meyerhof-Parnas pathway-associated genes to enhance NADPH regeneration in Escherichia coli

2019

Yuan, X.; Wang, J.; Lin, J.; Yang, L.; Wu, M.

J. Ind. Microbiol. Biotechnol.

46

1061-1069

761812

33460820

Dynamic control over feedback regulatory mechanisms improves NADPH flux and xylitol biosynthesis in engineered E. coli

2021

Li, S.; Ye, Z.; Moreb, E.A.; Hennigan, J.N.; Castellanos, D.B.; Yang, T.; Lynch, M.D.

Metab. Eng.

64

26-40

761832

29712559

Heterologous expression of Spathaspora passalidarum xylose reductase and xylitol dehydrogenase genes improved xylose fermentation ability of Aureobasidium pullulans

2018

Guo, J.; Huang, S.; Chen, Y.; Guo, X.; Xiao, D.

Microb. Cell Fact.

17

64

762303

-

Characterization of xylitol 4-dehydrogenase from Erwinia aphidicola and its co-expression with NADH oxidase in Bacillus subtilis

2021

Li, M.; Zhu, W.; Meng, Q.; Miao, M.; Zhang, T.

Process Biochem.

104

92-100

762689

-

In silico and in vitro comparison of nicotinamide adenine dinucleotide phosphate dependent xylose reductase Rossmann fold in Debaryomycetaceae yeast family

2020

Arumugam, N.; Boobalan, T.; Saravanan, S.; Jothi Basu, M.; Arun, A.; Suganya Devi, T.; Kavitha, T.

Biocatal. Agricult. Biotechnol.

24

101508

763625

32639976

Purification and characterization of a novel medium-chain ribitol dehydrogenase from a lichen-associated bacterium Sphingomonas sp.

2020

Tran, K.N.; Pham, N.; Jang, S.H.; Lee, C.

PLoS ONE

15

e0235718

764945

14690376

Multiple forms of xylose reductase in Candida intermedia comparison of their functional properties using quantitative structure-activity relationships, steady-state kinetic analysis, and pH studies

2003

Nidetzky, B.; Brueggler, K.; Kratzer, R.; Mayr, P.

J. Agric. Food Chem.

51

7930-7935