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BRENDA support

Ligand glutathione

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Basic Ligand Information

Molecular Structure
Picture of glutathione (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H17N3O6S
glutathione
RWSXRVCMGQZWBV-WDSKDSINSA-N
Synonyms:
5-L-glutamyl-Cys-Gly, gamma-Glu-Cys-Gly, gamma-Glu-L-Cys-Gly, gamma-glutathione, gamma-L-Glu-L-Cys-Gly, gamma-L-glutamyl-L-cysteinyl-glycine, glutathione-SH, glutathione/cytoplasm, glutathione/vacuole, glutathione[side 1], glutathione[side 2], GS-, GSH, L-gamma-Glu-L-Cys-Gly, L-glutathione, reduced glutathione, reduced L-glutathione, S-glutathione[side 1]
Pathway Source
Pathways
BRENDA
arachidonic acid metabolism, cysteine metabolism, formaldehyde oxidation, glutathione metabolism, methylglyoxal degradation more
KEGG
ABC transporters, Bile secretion, Biosynthesis of cofactors, Chemical carcinogenesis - reactive oxygen species, Cysteine and methionine metabolism more
MetaCyc
4-hydroxy-2-nonenal detoxification, 5-oxo-L-proline metabolism, alliin metabolism, alpha-linolenate metabolites biosynthesis, arachidonate metabolites biosynthesis more


Show all pahtways known for Show all BRENDA pathways known for glutathione

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3426 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
an (E)-omega-(methylthio)alkanal oxime + O2 + glutathione + [reduced NADPH-hemoprotein reductase] = an (E)-1-(glutathione-S-yl)-omega-(methylthio)alkylhydroximate + 2 H2O + [oxidized NADPH-hemoprotein reductase]
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glutathione + ascorbate + O2 = gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O
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arsenate + reduced glutathione = arsenite + glutathione
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glutathione + H2O + O2 = ?
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2 GSH + NADP+ = GSSG + NADPH + H+
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glutathione + O2 = glutathione disulfide + H2O2
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GSH + homocystine = GSSG + homocysteine
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CoA-glutathione + GSH = CoA + GSSG
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cystine + GSH = cysteine + GSSG
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sulfide + glutathione = sulfur + reduced glutathione
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glutathione + 2-(glutathione-S-yl)-hydroquinone = glutathione disulfide + hydroquinone
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glutathione + [Glu(-Cys)]n-Gly = Gly + [Glu(-Cys)]n+1-Gly
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an alkylcobalamin + [alkylcobalamin reductase] + glutathione = cob(I)alamin-[alkylcobalamin reductase] + an S-alkylglutathione
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