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Ligand 6-beta-iodopenicillanic acid Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C8 H1 0 INO3 S
6-beta-iodopenicillanic acid
XWDSFLSFDJZQTM-NDRTZFFLSA-N
Roles as Enzyme Ligand
Inhibitor in Enzyme-catalyzed Reactions (3 results)
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causes permanent inactivation
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the nature of the interactions of the rearranged inhibitor with conserved active site residues, the position of the inhibitor carboxylate and its interactions with Asn132, Asn104, and Asn170
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Enzyme Kinetic Parameters
References & Links Literature References (3)
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A comparative study of beta-lactamases
1993
Ledent, P.; Raquet, X.; Joris, B.; Van Beeumen, J.; Frere, J.M.
Biochem. J.
292
439-443
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Zinc D-Ala-D-Ala carboxypeptidase (Streptomyces)
2004
Ghuysen, J.
Handbook of Proteolytic Enzymes (Barrett,A. J. ;Rawlings,N. D. ,Woessner)
1
857-858
Structural basis of the inhibition of class A beta-lactamases and penicillin-binding proteins by 6-beta-iodopenicillanate
2009
Sauvage, E.; Zervosen, A.; Dive, G.; Herman, R.; Amoroso, A.; Joris, B.; Fonze, E.; Pratt, R.F.; Luxen, A.; Charlier, P.; Kerff, F.
J. Am. Chem. Soc.
131
15262-15269
Links to other databases for 6-beta-iodopenicillanic acid