Ligand adenosylcobalamin

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Basic Ligand Information

Molecular Structure
Picture of adenosylcobalamin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C72H102CoN18O17P
adenosylcobalamin
ZIHHMGTYZOSFRC-CXGXMSGESA-L
Synonyms:
5'-deoxy-5'-adenosylcobalamin, 5'-deoxyadenosylcobalamin, 5'-deoxyadenosylcobinamide, adenosyl-B12, adenosylcob(I)alamine, adenosylcob(III)alamin, adenosylcobalamine, adenylcobamide, alpha-(5,6-dimethylbenzimidazolyl)deoxyadenosylcobamide, alpha-(adenyl)-Co-5'-deoxyadenosyl cobamide, coenzyme B12, deoxyadenosylcobalamin, vitamin B12 coenzyme


Show all pahtways known for Show all BRENDA pathways known for adenosylcobalamin

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5'-deoxyadenosylcobalamin + [alkylcobalamin reductase] + glutathione = cob(I)alamin-[alkylcobalamin reductase] + S-5'-deoxyadenosylglutathione
show the reaction diagram
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ATP + 5'-deoxyadenosylcobinamide = 5'-deoxyadenosylcobinamide phosphate + ADP
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (28 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
NADPH + hydroxycobalamin = NADP+ + 5'-deoxyadenosylcobalamin
show the reaction diagram
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NADPH + hydroxycobalamin = NADP+ + 5'-deoxyadenosylcobalamin
show the reaction diagram
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adenosylcobalamin 5'-phosphate + H2O = adenosylcobalamin + phosphate
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (92 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
required as methyl acceptor for the methyl transfer activity of recombinant enzyme from E. coli
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dependent on
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dependent on
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Activator in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
i.e. adenosylcob(III)alamin, is required for stimulation of eut operon expression
-
required
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Inhibitor in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.174
-
pH 8.0, 20°C
0.251
-
pH 8.8, 37°C

KM Value (16 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.066
-
pH 8.8, 37°C

References & Links

Links to other databases for adenosylcobalamin

ChEBI
PubChem
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PubChem