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BRENDA support

Ligand (2E,6E)-farnesal

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Basic Ligand Information

Molecular Structure
Picture of (2E,6E)-farnesal (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C15H24O
(2E,6E)-farnesal
YHRUHBBTQZKMEX-YFVJMOTDSA-N
Synonyms:
(2E,6E)-farnesyl aldehyde, 2-trans,6-trans-farnesal, 3,7,11-trimethyl-2,6,10-dodecatrien-1-al, farnesal, farnesyl aldehyde, trans,trans-farnesal

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
farnesol + NADP+ = farnesal + NADPH
show the reaction diagram
-
(2E,6E)-farnesol + NAD+ = (2E,6E)-farnesal + NADH + H+
show the reaction diagram
-
S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O = (2E,6E)-farnesal + L-cysteine + H2O2
show the reaction diagram
-
S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O = (2E,6E)-farnesal + L-cysteine + H2O2
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
farnesal + NADPH + H+ = trans,trans-farnesol + NADP+
show the reaction diagram
-
farnesyl aldehyde + NAD(P)H = farnesol + NAD(P)+
show the reaction diagram
-
farnesal + NAD+ + H2O = farnesoic acid + NADH + H+
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
farnesol + NADP+ = farnesal + NADPH
show the reaction diagram
-
farnesol + NAD+ = farnesal + NADH + H+
show the reaction diagram
-
farnesol + NADP+ = farnesal + NADPH + H+
show the reaction diagram
-
(2E,6E)-farnesol + NAD+ = (2E,6E)-farnesyl aldehyde + NADH + H+
show the reaction diagram
-
(2E,6E)-farnesol + NAD+ = (2E,6E)-farnesal + NADH + H+
show the reaction diagram
-
farnesol + NAD+ = farnesal + NADH + H+
show the reaction diagram
-
farnesol + NAD+ = 3,7,11-trimethyl-2,6,10-dodecatrien-1-al + NADH
show the reaction diagram
-
farnesol + phenazine methosulfate = farnesal + reduced phenazine methosulfate
show the reaction diagram
-
farnesol + O2 = farnesal + H2O2
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
massive accumulation of the potentially toxic farnesal can stimulate the activity of a farnesal reductase or another enzyme that could convert farnesal back into farnesol
-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
non-competitive versus farnesyl-L-cysteine
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.93
-
-

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.023
-
-
0.13
-
pH 9.5, 35°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.05
-
recombinant enzyme, pH 7.5, 30°C

References & Links

Links to other databases for (2E,6E)-farnesal

ChEBI
PubChem
ChEBI
PubChem