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Ligand propionyl-CoA

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

aclacinomycin biosynthesis, alanine metabolism, androgen and estrogen metabolism, bile acid biosynthesis, neutral pathway, CO2 fixation in Crenarchaeota, ethylmalonyl-CoA pathway, isoleucine metabolism, macrolide antibiotic biosynthesis, methylaspartate cycle, propanol degradation, propionate fermentation, threonine metabolism, valine metabolism more

KEGG

beta-Alanine metabolism, Biosynthesis of 12-, 14- and 16-membered macrolides, Biosynthesis of secondary metabolites, Biosynthesis of type II polyketide backbone, C5-Branched dibasic acid metabolism, Carbon fixation pathways in prokaryotes, Carbon metabolism, Degradation of aromatic compounds, Glyoxylate and dicarboxylate metabolism, Microbial metabolism in diverse environments, Propanoate metabolism, Valine, leucine and isoleucine degradation, Xylene degradation more

MetaCyc

(S)-lactate fermentation to propanoate, acetate and hydrogen, (S)-propane-1,2-diol degradation, 2,4-dinitrotoluene degradation, 2-methyl-branched fatty acid beta-oxidation, 2-methylcitrate cycle I, 2-methylcitrate cycle II, 2-oxobutanoate degradation I, 2-oxobutanoate degradation II, 3,3'-disulfanediyldipropannoate degradation, 3,3'-thiodipropanoate degradation, 3-hydroxypropanoate cycle, 3-hydroxypropanoate/4-hydroxybutanate cycle, 4-oxopentanoate degradation, aclacinomycin biosynthesis, acrylate degradation II, anaerobic energy metabolism (invertebrates, mitochondrial), androstenedione degradation I (aerobic), androstenedione degradation II (anaerobic), beta-alanine biosynthesis II, bile acid biosynthesis, neutral pathway, cholesterol degradation to androstenedione I (cholesterol oxidase), cholesterol degradation to androstenedione II (cholesterol dehydrogenase), cholesterol degradation to androstenedione III (anaerobic), conversion of succinate to propanoate, crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered), daunorubicin biosynthesis, erythromycin D biosynthesis, ethylmalonyl-CoA pathway, formaldehyde assimilation I (serine pathway), glyoxylate assimilation, L-isoleucine biosynthesis IV, L-isoleucine degradation I, L-threonine degradation I, L-threonine degradation V, L-valine degradation I, methylaspartate cycle, platensimycin biosynthesis, propanoate fermentation to 2-methylbutanoate, propanoyl CoA degradation I, propanoyl-CoA degradation II, pyruvate fermentation to propanoate I, pyruvate fermentation to propanoate II (acrylate pathway), sitosterol degradation to androstenedione, valproate beta-oxidation, volatile esters biosynthesis (during fruit ripening) more

Show all BRENDA pathways known for propionyl-CoA

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (35 results)

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Show Natural Substrate (35 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.10

propanoyl-CoA + NADH + H+ = propanal + CoA + NAD+

742372

-

1.2.1.87

propanoyl-CoA + NADH + H+ = propanal + CoA + NAD+

742372

-

2.1.3.1

propionyl-CoA + oxaloacetate = (S)-methylmalonyl-CoA + pyruvate

485816

-

2.3.1.137

propionyl-CoA + L-carnitine = CoA + propionyl-carnitine

686028

-

2.3.1.167

propionyl-CoA + 10-deacetylbaccatin III = CoA + 10-deacetyl-10-propionylbaccatin III

672726

-

2.3.1.176

3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA

685342

-

2.3.1.180

propionyl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2

486934

-

2.3.1.222

propanoyl-CoA + phosphate = CoA + propanoyl phosphate

719708

-

2.3.1.36

propionyl-CoA + D-alanine = CoA + N-propionyl-D-alanine

486807

-

2.3.1.36

propionyl-CoA + D-allo-isoleucine = CoA + N-propionyl-D-allo-isoleucine

486807

-

2.3.1.36

propionyl-CoA + D-glutamine = CoA + N-propionyl-D-glutamine

486807

-

2.3.1.36

propionyl-CoA + D-leucine = CoA + N-propionyl-D-leucine

486807

-

2.3.1.36

propionyl-CoA + D-serine = CoA + N-propionyl-D-serine

486807

-

2.3.1.36

propionyl-CoA + D-tryptophan = CoA + N2-propionyl-D-tryptophan

486807

-

2.3.1.94

propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ = 6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+

701714, 702545, 702843, 705513, 705525, 706566, 706754, 702385

-

2.3.1.94

6 methylmalonyl-CoA + propionyl-CoA + 6 NADPH + 6 H+ = 6-deoxyerythronolide b + 7 CoA + 6 CO2 + H2O + 6 NADP+

487722

-

2.3.1.B34

propionyl-CoA + [AcsA]-L-Lys = CoA + [AcsA]-N6-propionyl-L-Lys

755801

-

2.3.1.B34

propionyl-CoA + [PprE]-L-Lys = CoA + [PprE]-N6-propionyl-L-Lys

756044

-

2.3.1.36

6 entries

2.3.1.94

2 entries

2.3.1.B34

2 entries

2.3.3.11

propanoyl-CoA + glyoxylate = 2-hydroxyglutarate + CoA

488127, 488124, 488125

-

2.3.3.16

propanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA

747131

-

2.3.3.16

propionyl-CoA + H2O + oxaloacetate = (2S,3S)-2-methylcitrate + CoA

747131

-

2.3.3.5

propanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA

735795, 735578, 747131, 757604, 757102, 756131

-

2.3.3.5

propanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-methylcitrate + CoA

488089

-

2.3.3.5

propanoyl-CoA + H2O + oxaloacetate = 2-methylcitrate + CoA

488171, 488172, 488175, 488173, 488174, 488176, 5348, 488087, 488165, 488170, 488168, 488166, 5344

-

2.3.3.5

propionyl-CoA + H2O + oxaloacetate = (2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA

705770, 705576, 703115

-

2.8.3.1

acetate + propanoyl-CoA = acetyl-CoA + propanoate

724088

-

2.8.3.1

propionyl-CoA + succinate = propanoate + succinoyl-CoA

738980

-

2.3.3.16

2 entries

2.3.3.5

4 entries

2.8.3.1

2 entries

2.8.3.27

propanoyl-CoA + succinate = propanoate + succinyl-CoA

764127, 764526

-

3.1.2.18

propionyl-CoA + H2O = CoA + propionate

646112

-

4.1.3.24

propionyl-CoA + glyoxylate = (2S)-4-(beta-methyl)-malyl-CoA

746671

4l80, 3D-view

4.1.3.24

propionyl-CoA + glyoxylate = (2S)-4-(beta-methyl)-malyl-CoA

746671

4l9y, 3D-view

6.4.1.2

ATP + propionyl-CoA + HCO3- + H+ = ADP + succinyl-CoA + phosphate

662786

-

6.4.1.2

ATP + propionyl-CoA + HCO3- = ADP + phosphate + methylmalonyl-CoA

745205

-

6.4.1.3

ATP + propanoyl-CoA + HCO3- = ?

1879

1xny, 3D-view

6.4.1.3

ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

651169, 651638, 653148, 649502, 651406, 652691, 653242, 653246, 653247, 651459

1xny, 3D-view

4.1.3.24

2 entries

6.4.1.2

2 entries

6.4.1.3

2 entries

In Vivo Product in Enzyme-catalyzed Reactions (22 results)

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Show Natural Product (22 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.10

propanal + CoA + NAD+ = propionyl-CoA + NADH

390177, 390166

-

1.2.1.10

propionaldehyde + CoA + NAD+ = propionyl-CoA + NADH + H+

0

-

1.2.1.27

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH

0

-

1.2.1.27

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH + H+

0

-

1.2.1.27

2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH

0

-

1.2.1.27

methylmalonate-semialdehyde + CoA + NAD+ = propionyl-CoA + NADH + H+ + HCO3-

0

-

1.2.1.10

2 entries

1.2.1.27

4 entries

1.2.1.87

propanal + CoA + NAD+ = propanoyl-CoA + NADH + H+

0

-

1.3.1.84

acrylyl-CoA + NADPH + H+ = propanoyl-CoA + NADP+

0

-

1.3.1.84

acrylyl-CoA + NADPH + H+ = propionyl-CoA + NADP+

0

-

1.3.1.84

2 entries

1.3.8.1

2-propenoyl-CoA + reduced electron transfer flavoprotein = propanoyl-CoA + electron transfer protein

391284

-

2.1.3.1

(S)-methylmalonyl-CoA + pyruvate = propanoyl-CoA + oxaloacetate

0

-

2.3.1.9

2-methylacetoacetyl-CoA + CoA = acetyl-CoA + propionyl-CoA

0

-

2.8.3.1

acetyl-CoA + propanoate = acetate + propanoyl-CoA

0

-

2.8.3.1

acetyl-CoA + propionate = acetate + propanoyl-CoA

0

-

3.13.1.4

3-sulfinopropanoyl-CoA + H2O = propanoyl-CoA + sulfite

0

-

3.13.1.4

3-sulfinopropionyl-CoA + H2O = propionyl-CoA + sulfite

0

-

4.1.3.24

(2R,3S)-2-methylmalyl-CoA = propanoyl-CoA + glyoxylate

0

4l80, 3D-view

4.1.3.24

(2R,3S)-2-methylmalyl-CoA = propanoyl-CoA + glyoxylate

0

4l9y, 3D-view

2.8.3.1

2 entries

3.13.1.4

2 entries

4.1.3.24

2 entries

6.2.1.1

ATP + propionate + CoA = AMP + diphosphate + propionyl-CoA

0

-

6.2.1.17

ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA

0

-

6.2.1.17

ATP + 3-hydroxypropionate + CoA + NADPH = AMP + diphosphate + NADP+ + propionyl-CoA

0

-

6.2.1.17

2 entries

7.2.4.3

(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2] = propanoyl-CoA + CO2 + Na+[side 2]

0

-

Substrate in Enzyme-catalyzed Reactions (142 results)

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Show Substrate (142 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.10

propanoyl-CoA + NADH + H+ = propanal + CoA + NAD+

742372

-

1.2.1.87

propanoyl-CoA + NADH + H+ = propanal + CoA + NAD+

742372

-

1.2.7.4

propionyl-SCoA + CoASH = propionyl-SCoA + CoASH

390469

-

1.3.8.1

propionyl-CoA + 2,6-dichlorophenolindophenol = 2-propenoyl-CoA + reduced acceptor

391269, 391300, 391308

-

1.3.8.1

propionyl-CoA + electron transfer flavoprotein = 2-propenoyl-CoA + reduced acceptor

391201

-

1.3.8.1

propionyl-CoA + phenazine methosulfate = 2-propenoyl-CoA + reduced acceptor

391201

-

1.3.8.1

3 entries

2.1.3.1

propionyl-CoA + oxaloacetate = (S)-methylmalonyl-CoA + pyruvate

485817, 485818, 485819, 485822, 4552, 485833, 485816, 485825, 485823, 485826, 485827, 485828, 485829, 485830, 485831, 485832, 485834

-

2.3.1.1

n-propionyl-CoA + L-glutamate = CoA + N-propionyl-L-glutamate

661651

-

2.3.1.1

propionyl-CoA + L-glutamate = CoA + N-propionyl-L-glutamate

486062, 486068, 486071, 486067, 486061, 735706

-

2.3.1.1

2 entries

2.3.1.107

propionyl-CoA + 17-O-deacetylvindoline = CoA + 17-O-deacetyl-17-O-propionylvindoline

486111

-

2.3.1.118

propionyl-CoA + 2-hydroxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole = CoA + N-propionyloxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole

486156

-

2.3.1.136

Neisseria meningitidis serogroup C capsular polysaccharide + propionyl-CoA = ?

702229

-

2.3.1.136

propionyl-CoA + colominic acid = CoA + O-(propionyl)-colominic acid

687583

-

2.3.1.137

propionyl-CoA + L-carnitine = CoA + propionyl-carnitine

686028

-

2.3.1.137

propionyl-CoA + L-carnitine = propionyl-L-carnitine + CoA

486290, 486292

-

2.3.1.136

2 entries

2.3.1.137

2 entries

2.3.1.150

n-Propionyl-CoA + salutaridinol = ?

16324

-

2.3.1.157

n-propionyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + N-propionyl-alpha-D-glucosamine 1-phosphate

756049

-

2.3.1.157

propionyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + N-propionyl-alpha-D-glucosamine 1-phosphate

756049

-

2.3.1.157

2 entries

2.3.1.16

propionyl-CoA + H2O = propionate + CoA

664215

-

2.3.1.165

propionyl-CoA + malonyl-CoA + NADPH = 6-ethylsalicylate + CoA + CO2 + NADP+

486445

-

2.3.1.165

propionyl-CoA + malonyl-CoA = 6-ethyl triacetic acid lactone + CoA

486451

-

2.3.1.165

propionyl-CoA + pantetheine = propionyl pantetheine + CoA

486445

-

2.3.1.167

propionyl-CoA + 10-deacetylbaccatin III = CoA + 10-deacetyl-10-propionylbaccatin III

672726

-

2.3.1.167

propionyl-CoA + 10-deacetylbaccatin III = CoA + 10-propionyl-10-deacetylbaccatin III

673024

-

2.3.1.165

3 entries

2.3.1.167

2 entries

2.3.1.176

3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA

685342

-

2.3.1.178

propionyl-CoA + L-2,4-diaminobutanoate = CoA + N4-propionyl-L-2,4-diaminobutanoate

661224

-

2.3.1.18

propionyl-CoA + p-nitrophenyl-beta-D-galactopyranoside = CoA + p-nitrophenyl 6-O-propionyl-beta-D-galactopyranoside

486466

-

2.3.1.180

propanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxopentanoyl-[acyl-carrier-protein] + CoA + CO2

761373

-

2.3.1.180

propionyl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2

660466, 486937, 486934, 665468

-

2.3.1.180

2 entries

2.3.1.186

n-propionyl-CoA + pseudotropine = CoA + O-n-propionylpseudotropine

682287

-

2.3.1.19

n-propionyl-CoA + phosphate = n-propionylphosphate + CoA

486470

-

2.3.1.19

propionyl-CoA + phosphate = CoA + propionyl phosphate

756087

-

2.3.1.19

propionyl-CoA + phosphate = propionyl phosphate + CoA

756087

-

2.3.1.19

3 entries

2.3.1.2

propanoyl-CoA + imidazole = CoA + N-propanoylimidazole

486478

-

2.3.1.222

propanoyl-CoA + phosphate = CoA + propanoyl phosphate

719708, 758101, 756682

-

2.3.1.222

propionyl-CoA + phosphate = CoA + propionyl phosphate

756682

-

2.3.1.222

2 entries

2.3.1.280

propionyl-CoA + (S)-1-aminoethylphosphonic acid = CoA + ?

749881

-

2.3.1.29

n-propionyl-CoA + glycine = CoA + 2-amino-3-oxopentanoate

486740

-

2.3.1.30

propionyl-CoA + L-serine = CoA + O-propionyl-L-serine

657835

-

2.3.1.31

propionyl-CoA + L-homoserine = CoA + O-propionyl-L-homoserine

486788, 671984, 673497

-

2.3.1.36

propionyl-CoA + D-alanine = CoA + N-propionyl-D-alanine

486807

-

2.3.1.36

propionyl-CoA + D-allo-isoleucine = CoA + N-propionyl-D-allo-isoleucine

486807

-

2.3.1.36

propionyl-CoA + D-glutamine = CoA + N-propionyl-D-glutamine

486807

-

2.3.1.36

propionyl-CoA + D-leucine = CoA + N-propionyl-D-leucine

486807

-

2.3.1.36

propionyl-CoA + D-serine = CoA + N-propionyl-D-serine

486807

-

2.3.1.36

propionyl-CoA + D-tryptophan = CoA + N2-propionyl-D-tryptophan

486807

-

2.3.1.36

6 entries

2.3.1.37

propionyl-CoA + glycine = ?

486819

-

2.3.1.38

propionyl-CoA + [acyl-carrier protein] = CoA + propionyl-[acyl-carrier protein]

486863, 486865

-

2.3.1.39

propionyl-CoA + acyl-carrier protein = CoA + propionyl-[acyl-carrier protein]

4866

-

2.3.1.39

propionyl-CoA + an [acyl-carrier protein] = CoA + propionyl-[acyl carrier protein]

755871

-

2.3.1.39

2 entries

2.3.1.4

propionyl-CoA + D-glucosamine 6-phosphate = CoA + N-propionyl-D-glucosamine 6-phosphate

755991, 486901

-

2.3.1.47

propionyl-CoA + L-arginine = N-[(4S)-4-amino-5-oxoheptyl]guanidine + CO2 + CoA

758497

-

2.3.1.48

histone + propionyl-CoA = propionyl-histone + CoA

672263

5h84, 3D-view

2.3.1.48

histone + propionyl-CoA = propionyl-histone + CoA

672263

5lkx, 3D-view

2.3.1.48

histone + propionyl-CoA = propionyl-histone + CoA

672263

5wci, 3D-view

2.3.1.48

histone + propionyl-CoA = propionyl-histone + CoA

672263

7d0p, 3D-view

2.3.1.48

piccoloNuA4 peptide + propionyl-CoA = propionyl-piccoloNuA4 peptide + CoA

672263

5h84, 3D-view

2.3.1.48

piccoloNuA4 peptide + propionyl-CoA = propionyl-piccoloNuA4 peptide + CoA

672263

5lkx, 3D-view

2.3.1.48

piccoloNuA4 peptide + propionyl-CoA = propionyl-piccoloNuA4 peptide + CoA

672263

5wci, 3D-view

2.3.1.48

piccoloNuA4 peptide + propionyl-CoA = propionyl-piccoloNuA4 peptide + CoA

672263

7d0p, 3D-view

2.3.1.48

8 entries

2.3.1.5

propionyl-CoA + 5-aminosalicylate = CoA + N-propionyl-5-aminosalicylate

758541

-

2.3.1.66

propionyl-CoA + L-leucine = CoA + propionyl-L-leucine

487374

-

2.3.1.67

propionyl-CoA + alkyl-lyso-glycero-phosphocholine = CoA + 2-propionyl-1-alkyl-sn-glycero-3-phosphocholine

487375, 487377

-

2.3.1.7

propionyl-CoA + carnitine = CoA + O-propionylcarnitine

756901

-

2.3.1.7

propionyl-CoA + L-(-)carnitine = propionylcarnitine + CoASH

486295, 487422, 487423, 487416, 487427, 487404, 487406, 487407, 487410, 487417, 487405

-

2.3.1.7

propionyl-CoA + L-carnitine = CoA + O-propionyl-L-carnitine

487423

-

2.3.1.7

propionyl-CoA + L-carnitine = CoA + O-propionylcarnitine

735697, 736607

-

2.3.1.7

4 entries

2.3.1.71

propionyl-CoA + glycine = CoA + N-propionylglycine

486269, 486265

-

2.3.1.8

propionyl-CoA + phosphate = CoA + propionyl phosphate

487527, 704759, 487537, 487513, 756682

-

2.3.1.81

N-propionyl-CoA + amikacin = CoA + N3'-propionyl-amikacin

703205

-

2.3.1.81

N-propionyl-CoA + gentamicin = CoA + N3'-propionyl-gentamicin

703205

-

2.3.1.81

n-propionyl-CoA + kanamycin A = CoA + N3'-n-propionylkanamycin A

718871

-

2.3.1.81

N-propionyl-CoA + kanamycin A = CoA + N3'-propionyl-kanamycin A

703205

-

2.3.1.81

N-propionyl-CoA + neomycin B = CoA + N3-propionylneomycin B

703205

-

2.3.1.81

N-propionyl-CoA + paromomycin = CoA + N3'-propionyl-paromomycin

703205

-

2.3.1.81

N-propionyl-CoA + sisomicin = CoA + N3'-propionyl-sisomicin

703205

-

2.3.1.81

N-propionyl-CoA + tobramycin = CoA + N3'-propionyl-tobramycin

703205

-

2.3.1.81

propionyl-CoA + ribostamycin = CoA + ?

672007

-

2.3.1.82

n-propionyl-CoA + sisomycin = CoA + ?

659093

-

2.3.1.82

propionyl-CoA + kanamycin A = CoA + N6'-propionylkanamycin A

636910

-

2.3.1.82

propionyl-CoA + tobramycin = CoA + N6'-propionyltobramycin

636913

-

2.3.1.81

9 entries

2.3.1.82

3 entries

2.3.1.84

propionyl-CoA + cinnamyl alcohol = CoA + cinnamyl propionate

720138

-

2.3.1.87

propionyl-CoA + histamine = CoA + N-propionylhistamine

758432

-

2.3.1.87

propionyl-CoA + tyramine = CoA + N-propionyltyramine

758432

-

2.3.1.87

2 entries

2.3.1.9

acetyl-CoA + propionyl-CoA = CoA + 3-oxopentanoyl-CoA

726744

-

2.3.1.93

propionyl-CoA + 13-hydroxylupanine = CoA + 13-propionyloxylupanine

487720

-

2.3.1.94

propanoyl-CoA + (2S)-methylmalonyl-CoA + NADPH = (3R,4S,5R,6R)-6-ethyl-4-hydroxy-3,5-dimethyloxan-2-one + ?

756037

-

2.3.1.94

propanoyl-CoA + 5 (2S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 6 NADPH + 6 H+ = (3R,4S,5R,6R)-6-ethyl-4-hydroxy-3,5-dimethyltetrahydro-2H-pyran-2-one + ?

736307

-

2.3.1.94

propanoyl-CoA + 5 (2S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 6 NADPH + 6 H+ = (3R,5R,6S)-6-[(2S,3R)-3-hydroxypentan-2-yl]-3,5-dimethyldihydro-2H-pyran-2,4(3H)-dione + ?

736307

-

2.3.1.94

propanoyl-CoA + 5 (2S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 6 NADPH + 6 H+ = 8-ethyl-8-desmethyl-6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+

736307

-

2.3.1.94

propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ = 6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+

701714, 702545, 702843, 705513, 705525, 706566, 706754, 702385, 735679, 736307

-

2.3.1.94

6 methylmalonyl-CoA + propionyl-CoA + 6 NADPH + 6 H+ = 6-deoxyerythronolide b + 7 CoA + 6 CO2 + H2O + 6 NADP+

487722

-

2.3.1.B34

propionyl-CoA + [AcsA]-L-Lys = CoA + [AcsA]-N6-propionyl-L-Lys

755801

-

2.3.1.B34

propionyl-CoA + [PprE]-L-Lys = CoA + [PprE]-N6-propionyl-L-Lys

756044

-

2.3.3.11

propanoyl-CoA + glyoxylate + H2O = 2-hydroxyglutarate + CoA

488124, 488125, 488126, 488127

-

2.3.3.11

propanoyl-CoA + glyoxylate = 2-hydroxyglutarate + CoA

488127, 488124, 488125

-

2.3.3.13

2-oxo-3-methylbutanoate + propanoyl-CoA + H2O = 2-hydroxy-2-isopropyl-3-methylsuccinic acid + CoA

636517

-

2.3.3.13

propionyl-CoA + H2O = propanoate + CoA

672203

-

2.3.3.16

propanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA

747131

-

2.3.3.16

propionyl-CoA + H2O + oxaloacetate = (2S,3S)-2-methylcitrate + CoA

747131

-

2.3.3.16

propionyl-CoA + oxaloacetate + H2O = 2-methylcitrate + CoA

488084, 488087, 488089

-

2.3.3.5

propanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA

757102, 735795, 735578, 755708, 756131, 757604, 747131

-

2.3.3.5

propanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-methylcitrate + CoA

671529, 488089, 661700

-

2.3.3.5

propanoyl-CoA + H2O + oxaloacetate = 2-methylcitrate + CoA

488087, 488166, 488171, 488172, 488173, 488174, 488175, 488176, 5348, 488170, 488168, 5344, 488165, 704332, 720336

-

2.3.3.5

propionyl-CoA + H2O + oxaloacetate = (2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA

705770, 705576, 703115

-

2.3.1.94

6 entries

2.3.1.B34

2 entries

2.3.3.11

2 entries

2.3.3.13

2 entries

2.3.3.16

3 entries

2.3.3.5

4 entries

2.3.3.9

glyoxylate + propionyl-CoA + H2O = 2-oxopentanedioic acid + CoA

638478

-

2.8.3.1

acetate + propanoyl-CoA = acetyl-CoA + propanoate

724088

-

2.8.3.1

(R)-lactate + propionyl-CoA = propionate + (R)-lactoyl-CoA

645949

-

2.8.3.1

propionyl-CoA + acetate = propanoate + acetyl-CoA

661640

-

2.8.3.1

propionyl-CoA + propanoate = ?

737535

-

2.8.3.1

propionyl-CoA + succinate = propanoate + succinoyl-CoA

738980

-

2.8.3.1

5 entries

2.8.3.10

propionyl-CoA + citrate = propionate + (3S)-citryl-CoA

643831

-

2.8.3.14

propionyl-CoA + (Z)-5-hydroxy-2-pentenoate = propionate + (Z)-5-hydroxy-2-pentenoyl-CoA

643835

-

2.8.3.14

propionyl-CoA + acetate = acetyl-CoA + propanoate

643835

-

2.8.3.14

2 entries

2.8.3.27

propanoyl-CoA + succinate = propanoate + succinyl-CoA

764127, 765011, 765332, 764526, 765369, 763982

-

2.8.3.3

propionyl-CoA + malonate = malonyl-CoA + propanoate

4864

-

3.1.2.1

propionyl-CoA + H2O = CoA + propionate

94468, 94472, 94470, 94488, 94487

-

3.1.2.17

propionyl-CoA + H2O = propionate + CoA

643853, 643854

-

3.1.2.18

propionyl-CoA + H2O = CoA + propionate

646115, 646112, 646111

-

3.1.2.2

propionyl-CoA + H2O = CoA + propionate

646115, 646200, 646202

-

3.1.2.20

n-propionyl-CoA + H2O = CoA + n-propionate

707486

-

3.1.2.20

propionyl-CoA + H2O = CoA + propionate

646115, 646200, 646202, 690932, 698975

-

3.1.2.20

2 entries

3.5.1.51

propionyl-CoA + H2O = ?

209188

-

4.1.3.24

propionyl-CoA + glyoxylate = (2S)-4-(beta-methyl)-malyl-CoA

746671

4l80, 3D-view

4.1.3.24

propionyl-CoA + glyoxylate = (2S)-4-(beta-methyl)-malyl-CoA

746671

4l9y, 3D-view

4.1.3.24

propionyl-CoA + glyoxylate = erythro-beta-methylmalyl-CoA

665383, 651711

4l80, 3D-view

4.1.3.24

propionyl-CoA + glyoxylate = erythro-beta-methylmalyl-CoA

665383, 651711

4l9y, 3D-view

6.2.1.13

ADP + phosphate + propanoyl-CoA = ATP + propanoate + CoA

651644

-

6.2.1.13

ADP + phosphate + propionyl-CoA = ATP + propionate + CoA

625, 624, 744820

-

4.1.3.24

4 entries

6.2.1.13

2 entries

6.2.1.B11

ADP + phosphate + propionyl-CoA = ATP + propionate + CoA

744820

-

6.4.1.2

ATP + propionyl-CoA + HCO3- + H+ = ADP + succinyl-CoA + phosphate

662786, 661098

-

6.4.1.2

ATP + propionyl-CoA + HCO3- = ADP + methylmalonyl-CoA + phosphate

714212

-

6.4.1.2

ATP + propionyl-CoA + HCO3- = ADP + phosphate + methylmalonyl-CoA

37593, 37580, 745205, 37573, 37578, 37605, 37576, 37591, 37614, 37582, 37600, 651169

-

6.4.1.3

ATP + propanoyl-CoA + HCO3- = ?

1879

1xny, 3D-view

6.4.1.3

ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (2S)-methylmalonyl-CoA

702794

1xny, 3D-view

6.4.1.3

ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

662786, 651406, 651459, 652691, 653246, 653247, 662392, 653242, 649502, 653148, 651169, 651638, 716328, 725234

1xny, 3D-view

6.4.1.3

ATP + propanoyl-CoA + HCO3- = ADP + phosphate + methylmalonyl-CoA

1863, 1867, 1868, 1876, 1880, 1881, 1870, 1873, 1878, 1865, 1866, 1869, 1875, 1872, 1874, 1871, 1864, 1877, 679922, 1879

1xny, 3D-view

6.4.1.3

GTP + propanoyl-CoA + HCO3- = GDP + phosphate + (S)-methylmalonyl-CoA

651169

1xny, 3D-view

6.4.1.3

UTP + propanoyl-CoA + HCO3- = UDP + phosphate + (S)-methylmalonyl-CoA

651169

1xny, 3D-view

6.4.1.3

ATP + propionyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

726557

1xny, 3D-view

6.4.1.3

propionyl-CoA + CO2 = (2S)-methylmalonyl-CoA

704957, 713913

1xny, 3D-view

6.4.1.3

propionyl-CoA + CO2 = (S)-methylmalonyl-CoA

714212, 715895, 716328

1xny, 3D-view

6.4.1.2

3 entries

6.4.1.3

9 entries

Product in Enzyme-catalyzed Reactions (78 results)

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Show Product (78 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.10

propionaldehyde + CoA + NAD+ = propanoyl-CoA + NADH

0

-

1.2.1.10

propanal + CoA + NAD+ = propionyl-CoA + NADH

0, 390177, 390166

-

1.2.1.10

propionaldehyde + CoA + NAD+ = propionyl-CoA + NADH + H+

0

-

1.2.1.104

2-oxobutanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH

0

-

1.2.1.104

2-oxobutyrate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+

0

-

1.2.1.10

3 entries

1.2.1.104

2 entries

1.2.1.18

2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH

288055

-

1.2.1.27

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH

0

-

1.2.1.27

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH + H+

0

-

1.2.1.27

2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH

0, 390218, 390219, 390220, 288055

-

1.2.1.27

methylmalonate semialdehyde + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH

0

-

1.2.1.27

propanal + CoA + NAD+ = propanoyl-CoA + NADH

0, 390220

-

1.2.1.27

propionaldehyde + CoA + NAD+ = propanoyl-CoA + NADH

0

-

1.2.1.27

methylmalonate-semialdehyde + CoA + NAD+ = propionyl-CoA + NADH + H+ + HCO3-

0

-

1.2.1.27

7 entries

1.2.1.51

2-oxobutyrate + CoA + NADP+ = propionyl-CoA + CO2 + NADPH

0

-

1.2.1.57

propionaldehyde + NAD+ = propanoyl-CoA + NADH

0

-

1.2.1.87

propanal + CoA + NAD+ = propanoyl-CoA + NADH + H+

0

-

1.2.1.87

propionaldehyde + CoA + NAD+ = propanoyl-CoA + NADH + H+

0

-

1.2.7.1

2-oxobutyrate + CoA + 2 oxidized benzyl viologen = propanoyl-CoA + CO2 + 2 reduced benzyl viologen

0

-

1.2.7.1

2-oxobutyrate + CoA + 2 oxidized methyl viologen = propanoyl-CoA + CO2 + 2 reduced methyl viologen

0

-

1.2.7.1

2-oxobutyrate + CoA + oxidized methyl viologen = propanoyl-CoA + CO2 + reduced methyl viologen

0

-

1.2.7.11

2-oxobutanoate + CoA + 2 oxidized cytochrome c = propanoyl-CoA + CO2 + 2 reduced cytochrome c + 2 H+

0

-

1.2.7.11

2-oxobutyrate + CoA + 2 oxidized methyl viologen = propanoyl-CoA + CO2 + 2 reduced methyl viologen

0

-

1.2.7.11

2-oxobutyrate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin

0

-

1.2.1.87

2 entries

1.2.7.1

3 entries

1.2.7.11

3 entries

1.2.7.4

propionyl-SCoA + CoASH = propionyl-SCoA + CoASH

390469

-

1.2.7.7

2-ketobutyrate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin

0

-

1.3.1.84

acryloyl-CoA + NADPH + H+ = propanoyl-CoA + NADP+

0

-

1.3.1.84

acrylyl-CoA + NADH + H+ = propanoyl-CoA + NAD+

0

-

1.3.1.84

acrylyl-CoA + NADPH + H+ = propanoyl-CoA + NADP+

0

-

1.3.1.84

acrylyl-CoA + NADPH + H+ = propionyl-CoA + NADP+

0

-

1.3.1.95

acryloyl-CoA + NADH + H+ = propanoyl-CoA + NAD+

0

-

1.3.1.95

acryloyl-CoA + NADPH + H+ = propanoyl-CoA + NADP+

0

-

1.3.8.1

2-propenoyl-CoA + reduced electron transfer flavoprotein = propanoyl-CoA + electron transfer protein

0, 391284

-

1.3.8.1

acryloyl-CoA + benzyl viologen = propanoyl-CoA + reduced benzyl viologen

0

-

1.3.8.1

acryloyl-CoA + reduced methylviologen = propanoyl-CoA + oxidized methylviologen

0

-

1.3.1.84

4 entries

1.3.1.95

2 entries

1.3.8.1

3 entries

2.1.3.1

(S)-methylmalonyl-CoA + pyruvate = propanoyl-CoA + oxaloacetate

0

-

2.3.1.137

propionyl-L-carnitine + CoA = propionyl-CoA + L-carnitine

0

-

2.3.1.16

CoA + 3-oxopentanoyl-CoA = acetyl-CoA + propanoyl-CoA

0

-

2.3.1.222

CoA + propanoyl phosphate = propanoyl-CoA + phosphate

0

-

2.3.1.54

2-oxobutyrate + CoA = propionyl-CoA + formate

0

-

2.3.1.7

propionylcarnitine + CoASH = propionyl-CoA + L-(-)carnitine

0

-

2.3.1.9

2-methylacetoacetyl-CoA + CoA = acetyl-CoA + propionyl-CoA

0

-

2.8.3.1

acetyl-CoA + propanoate = acetate + propanoyl-CoA

0, 645947, 33928

-

2.8.3.1

acetyl-CoA + propionate = acetate + propanoyl-CoA

0

-

2.8.3.1

acrylate + acrylyl-CoA = acetate + propionyl-CoA

0

-

2.8.3.1

propionate + acetyl-CoA = acetate + propionyl-CoA

0

-

2.8.3.1

4 entries

2.8.3.12

glutaconyl-CoA + propionate = propanoyl-CoA + glutaconate

0

-

2.8.3.14

acetyl-CoA + propionate = acetate + propanoyl-CoA

643835

-

2.8.3.18

acetyl-CoA + propionate = propionyl-CoA + acetate

0

-

2.8.3.18

succinyl-CoA + propionate = propionyl-CoA + succinate

0

-

2.8.3.18

2 entries

2.8.3.27

propanoate + succinyl-CoA = propanoyl-CoA + succinate

0

-

2.8.3.9

propionate + acetoacetyl-CoA = propionyl-CoA + acetoacetate

643839, 643838

-

3.13.1.4

3-sulfinopropanoyl-CoA + H2O = propanoyl-CoA + sulfite

0

-

3.13.1.4

3-sulfinopropionyl-CoA + H2O = propionyl-CoA + sulfite

0

-

3.13.1.4

2 entries

4.1.1.9

methylmalonyl-CoA = propionyl-CoA + CO2

0, 4856, 651816

-

4.1.1.94

methylmalonyl-CoA = propanoyl-CoA + CO2

0

-

4.1.3.24

(2R,3S)-2-methylmalyl-CoA = propanoyl-CoA + glyoxylate

0

4l80, 3D-view

4.1.3.24

(2R,3S)-2-methylmalyl-CoA = propanoyl-CoA + glyoxylate

0

4l9y, 3D-view

4.1.3.24

beta-methylmalyl-CoA = glyoxylate + propionyl-CoA

0

4l80, 3D-view

4.1.3.24

beta-methylmalyl-CoA = glyoxylate + propionyl-CoA

0

4l9y, 3D-view

6.2.1.1

ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA

0

-

6.2.1.1

ATP + propionate + CoA = AMP + diphosphate + propionyl-CoA

550, 0

-

4.1.3.24

4 entries

6.2.1.1

2 entries

6.2.1.12

ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA

0

-

6.2.1.13

ATP + propionate + CoA = ADP + phosphate + propionyl-CoA

0

-

6.2.1.17

ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA

0, 654, 658, 653

-

6.2.1.17

propionyl-AMP + CoA = AMP + propanoyl-CoA

0

-

6.2.1.17

ATP + 3-hydroxypropionate + CoA + NADPH = AMP + diphosphate + NADP+ + propionyl-CoA

0

-

6.2.1.17

ATP + acrylate + CoA + NADPH = AMP + diphosphate + NADP+ + propionyl-CoA

0

-

6.2.1.17

GTP + 3-hydroxypropionate + CoA + NADPH = GMP + diphosphate + NADP+ + propionyl-CoA

0

-

6.2.1.17

UTP + 3-hydroxypropionate + CoA + NADPH = UMP + diphosphate + NADP+ + propionyl-CoA

0

-

6.2.1.2

ATP + propionate + CoA = AMP + diphosphate + propionyl-CoA

0, 650950

-

6.2.1.2

ATP + propionic acid + CoA = AMP + diphosphate + propionyl-CoA

0

-

6.2.1.30

ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA

0

-

6.2.1.30

ATP + propionic acid + CoA = AMP + diphosphate + propionyl-CoA

0

-

6.2.1.17

6 entries

6.2.1.2

2 entries

6.2.1.30

2 entries

6.2.1.36

propionate + ATP + coenzyme A = propionyl-CoA + AMP + diphosphate

0

-

6.2.1.44

ATP + propionate + CoA = AMP + diphosphate + propionyl-CoA

0

-

6.2.1.5

ATP + propionate + CoA = ADP + phosphate + propionyl-CoA

0

-

6.2.1.B11

ATP + propionate + CoA = ADP + phosphate + propionyl-CoA

0

-

7.2.4.3

(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2] = propanoyl-CoA + CO2 + Na+[side 2]

4545, 0, 4544

-

Enzyme Cofactor/Cosubstrate (1 result)

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Show Cofactor (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.B34

-

755801, 756044

-

Activator in Enzyme-catalyzed Reactions (6 results)

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Show Activating Compound (6 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.7.11.2

slight activation at low concentrations, synergism with NADH plus NAD+

642139

-

4.1.1.31

absolute requirement for acetyl-CoA or propionyl-CoA

4293

-

4.1.1.31

activates

4337

-

6.4.1.1

activation in decreasing order: acetyl-CoA, n-propanyl-CoA, n-butanoyl-CoA, malonyl-CoA/ CoA, acetoacetyl-CoA, oleoyl-CoA

1760

-

6.4.1.1

activates less efficiently than acetyl-CoA

649509

-

6.4.1.1

can replace acetyl-CoA with little efficiency

650301

-

4.1.1.31

2 entries

6.4.1.1

3 entries

Inhibitor in Enzyme-catalyzed Reactions (28 results)

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Show Inhibitors (28 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.35

-

739840

-

1.2.7.4

-

390468

-

1.3.8.1

-

391269

-

2.1.3.1

-

485816

-

2.3.1.1

-

486061

-

2.3.1.1

about 20% residual activity at 2.5 mM

735706

-

2.3.1.1

2 entries

2.3.1.17

weak

486456

-

2.3.1.21

CPT I, inhibition is not affected by proteinase treatment

486572

-

2.3.1.39

inhibition of both isozymes at 0.1 mM

486887

-

2.3.1.5

-

487115

-

2.3.3.10

-

488091

-

2.3.3.16

competitive against acetyl-CoA

488059

-

2.3.3.5

competitive to CoA

661700

-

2.7.1.33

-

641390

-

3.1.2.17

competitive inhibition

643853

-

3.1.2.4

competitive

94558

-

3.1.2.4

competitive inhibition

653127

-

3.1.2.4

2 entries

3.1.3.16

-

134616

-

4.1.1.9

-

4845, 4846, 4849, 4851, 4852, 4854, 4856

-

4.1.1.9

insensitive

4852

-

4.1.3.24

in direction of malyl-CoA synthesis: uncompetitive with respect to glyoxylate and competitive with respect to acetyl-CoA. In direction of malyl-CoA cleavage: noncompetitive with respect to malyl-CoA

33263

4l80, 3D-view

4.1.3.24

in direction of malyl-CoA synthesis: uncompetitive with respect to glyoxylate and competitive with respect to acetyl-CoA. In direction of malyl-CoA cleavage: noncompetitive with respect to malyl-CoA

33263

4l9y, 3D-view

4.2.1.17

0.1 mM, 60% inhibition

752454

-

4.2.1.17

0.1 mM, 60% inhibition

746710

-

4.1.1.9

2 entries

4.1.3.24

2 entries

4.2.1.17

2 entries

5.1.3.13

i.e. SID 7975595, a competitive, fast-on rate, fully reversible inhibitor of RmlC. Increases the Km for TDP-6-deoxy-D-xylo-hexopyranosid-4-ulose. Cytotoxic SID 7975595 has an IC50 of approximately 0.075 mM in HAE cells

702695

-

5.1.99.1

-

2434

-

6.4.1.2

below 0.1 mM almost as effective as substrate as acetyl-CoA, inhibitory at higher concentrations

37576

-

6.4.1.4

competitive with respect to 3-methylcrotonoyl-CoA

1884

-

3D Structure of Enzyme-Ligand-Complex (PDB) (43 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (43 entries)

EC NUMBER

ENZYME 3D STRUCTURE

2.3.1.48

5h84, 3D-view

2.3.1.48

5lkx, 3D-view

2.3.1.48

5wci, 3D-view

2.3.1.48

7d0p, 3D-view

2.3.1.48

5h84, 3D-view

2.3.1.48

5lkx, 3D-view

2.3.1.48

5wci, 3D-view

2.3.1.48

7d0p, 3D-view

2.3.1.48

5h84, 3D-view

2.3.1.48

5lkx, 3D-view

2.3.1.48

5wci, 3D-view

2.3.1.48

7d0p, 3D-view

2.3.1.48

5h84, 3D-view

2.3.1.48

5lkx, 3D-view

2.3.1.48

5wci, 3D-view

2.3.1.48

7d0p, 3D-view

2.3.1.48

5h84, 3D-view

2.3.1.48

5lkx, 3D-view

2.3.1.48

5wci, 3D-view

2.3.1.48

7d0p, 3D-view

2.3.1.48

5h84, 3D-view

2.3.1.48

5lkx, 3D-view

2.3.1.48

5wci, 3D-view

2.3.1.48

7d0p, 3D-view

2.3.1.48

5h84, 3D-view

2.3.1.48

5lkx, 3D-view

2.3.1.48

5wci, 3D-view

2.3.1.48

7d0p, 3D-view

4.1.3.24

4l80, 3D-view

4.1.3.24

4l9y, 3D-view

4.1.3.24

4l80, 3D-view

4.1.3.24

4l9y, 3D-view

4.1.3.24

4l80, 3D-view

4.1.3.24

4l9y, 3D-view

4.1.3.24

4l80, 3D-view

4.1.3.24

4l9y, 3D-view

4.1.3.24

4l80, 3D-view

4.1.3.24

4l9y, 3D-view

4.1.3.24

4l80, 3D-view

4.1.3.24

4l9y, 3D-view

4.1.3.24

4l80, 3D-view

4.1.3.24

4l9y, 3D-view

2.3.1.48

28 entries

4.1.3.24

14 entries

6.4.1.3

1xny, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (51 results)

top print hide

Show Turnover Number (51 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.3.8.1

0.03

-

-

391269

1.3.8.1

0.0333

-

-

391279

1.3.8.1

2 entries

2.3.1.136

0.09

-

mutant NeuO + 36 hepta-nucleotide repeats

687583

2.3.1.157

0.5

-

pH 7.5, 30°C

756049

2.3.1.157

0.5

-

pH 7.5, 30°C

756049

2.3.1.19

518.8

-

pH 7.5, 23°C

756087

2.3.1.19

518.8

-

pH 7.5, 25°C

756087

2.3.1.222

0.21

-

pH 7.6, 55°C

756682

2.3.1.222

0.21

-

pH 7.6, 55°C

756682

2.3.1.222

1.14

-

pH 7.6, 55°C

756682

2.3.1.222

1.14

-

pH 7.6, 55°C

756682

2.3.1.157

2 entries

2.3.1.19

2 entries

2.3.1.222

4 entries

2.3.1.280

14.7

-

cosubstrate: (S)-1-aminoethylphosphonic acid, pH 7.5, 25°C

749881

2.3.1.31

2.6

-

25°C, pH 7.5

673497

2.3.1.31

16.1

-

21°C, pH 8.0, wild-type enzyme

671984

2.3.1.31

30

-

-

486788

2.3.1.31

3 entries

2.3.1.8

0.21

-

pH 7.6, 55°C

756682

2.3.1.81

10.2

-

cosubstrate kanamycin A, pH 7.6, 25°C

718871

2.3.1.81

33

-

in 50 mM HEPES, pH 7.5 and 0.1 mM 4,4'-dithiodipyridine, at pH 7.8 and 25°C

672007

2.3.1.81

2 entries

2.3.1.82

0.317

-

pH 6.0, 37°C

636910

2.3.1.87

0.6

-

cosubstrate histamine, pH 7.0, 25°C

758432

2.3.1.87

2.3

-

cosubstrate octopamine, pH 7.0, 25°C

758432

2.3.1.87

2.7

-

cosubstrate tyramine, pH 7.0, 25°C

758432

2.3.1.94

0.0067

-

mutant H384A, pH 7.2, temperature not specified in the publication

756037

2.3.1.94

0.028

-

mutant Q386E, pH 7.2, temperature not specified in the publication

756037

2.3.1.94

0.032

-

mutant H457A, pH 7.2, temperature not specified in the publication

756037

2.3.1.94

0.038

-

mutant N381A, pH 7.2, temperature not specified in the publication

756037

2.3.1.94

0.038

-

mutant N455L, pH 7.2, temperature not specified in the publication

756037

2.3.1.94

0.04

-

mutant S315A, pH 7.2, temperature not specified in the publication

756037

2.3.1.94

0.042

-

wild-type, pH 7.2, temperature not specified in the publication

756037

2.3.1.94

0.048

-

mutant T209A, pH 7.2, temperature not specified in the publication

756037

2.3.1.87

3 entries

2.3.1.94

8 entries

2.3.3.13

0.04

-

hydrolysis, absence of MgCl2, pH 7.4, 25°C

672203

2.3.3.16

4

-

mutant loop/K313L/A361R

488084

2.3.3.16

6

-

mutant A361R

488084

2.3.3.16

8

-

wild-type

488084

2.3.3.16

12

-

dimeric enzyme form

488087

2.3.3.5

8.25

-

in 50 mM HEPES pH 8.0, at 30°C

720336

2.3.3.5

12.2

-

pH 8.0, temperature not specified in the publication, mutant enzyme G352A

756131

2.3.3.5

12.5

-

-

705576

2.3.3.5

15.9

-

-

705576

2.3.3.5

23

-

pH 8.0, 25°C, purified native enzyme

488089

2.3.3.5

30.1

-

pH 8.0, temperature not specified in the publication, wild-type enzyme

756131

2.3.3.16

4 entries

2.3.3.5

6 entries

2.8.3.27

0.72

-

at pH 7.0 and 25°C

764127

3.1.2.20

0.036

-

wild-type protein, pH7.5, 25°C

707486

3.1.2.20

25

-

pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay

690932

3.1.2.20

2 entries

4.1.3.24

12

-

at 30°C

704322

6.2.1.13

21

-

at pH 7.3 and 37°C

744820

6.2.1.B11

21

-

pH 7.3, 37°C, acetate-forming direction, with propionyl-CoA

744820

6.4.1.3

0.47

-

pH 8, 30°C, mutant A431I

726557

6.4.1.3

1.46

-

pH 8, 30°C, mutant A431C

726557

6.4.1.3

2

8

pH 7.5, 65°C

651169

6.4.1.3

2.86

-

pH 8, 30°C, wild-type

726557

6.4.1.3

4 entries

K_M Value (104 results)

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Show KM Value (104 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.2.7.4

5

-

-

390469

1.3.8.1

0.13

0.15

-

391269, 391274

2.1.3.1

0.034

-

-

485816

2.3.1.136

0.22

-

mutant NeuO + 36 hepta-nucleotide repeats

687583

2.3.1.150

0.068

-

-

16324

2.3.1.157

0.06

-

pH 7.5, 30°C

756049

2.3.1.157

0.06

-

pH 7.5, 30°C

756049

2.3.1.157

2 entries

2.3.1.18

0.098

-

p-nitrophenyl-beta-D-galactopyranoside

486466

2.3.1.19

0.1906

-

pH 7.5, 23°C

756087

2.3.1.19

0.1906

-

pH 7.5, 25°C

756087

2.3.1.222

0.04

-

pH 7.6, 55°C

756682

2.3.1.222

0.04

-

pH 7.6, 55°C

756682

2.3.1.222

0.12

-

pH 7.6, 55°C

756682

2.3.1.222

0.12

-

pH 7.6, 55°C

756682

2.3.1.19

2 entries

2.3.1.222

4 entries

2.3.1.280

0.07

-

cosubstrate: (S)-1-aminoethylphosphonic acid, pH 7.5, 25°C

749881

2.3.1.29

0.08

-

-

486740

2.3.1.31

0.044

-

25°C, pH 7.5

673497

2.3.1.31

0.0484

-

21°C, pH 8.0, wild-type enzyme

671984

2.3.1.31

0.09

-

-

486788

2.3.1.31

3 entries

2.3.1.36

0.263

-

-

486807

2.3.1.4

0.13

-

pH 7.6, 37°C

755991

2.3.1.67

0.128

-

-

487377

2.3.1.7

0.014

-

-

487407

2.3.1.7

0.0173

-

-

487423

2.3.1.7

0.028

-

-

487416, 487423, 487427

2.3.1.7

0.034

-

peroxisomal enzyme

487427

2.3.1.7

0.037

-

-

487423

2.3.1.7

0.1

-

peroxisomal enzyme

487406, 487427

2.3.1.7

0.162

-

mitochondrial enzyme

487406, 487427

2.3.1.7

0.185

-

mitochondrial enzyme

487427

2.3.1.8

0.04

-

pH 7.6, 55°C

756682

2.3.1.8

0.15

-

-

487527

2.3.1.81

0.0886

-

cosubstrate kanamycin A, pH 7.6, 25°C

718871

2.3.1.81

0.499

-

in 50 mM HEPES, pH 7.5 and 0.1 mM 4,4'-dithiodipyridine, at pH 7.8 and 25°C

672007

2.3.1.82

0.0161

-

pH 8.0, 30°C, cosubstrate: sisomycin

659093

2.3.1.82

0.0195

-

pH 6.0, 37°C

636910

2.3.1.82

0.27

-

reaction with tobramycin, wild-type enzyme

636913

2.3.1.87

0.066

-

cosubstrate octopamine, pH 7.0, 25°C

758432

2.3.1.87

0.098

-

cosubstrate tyramine, pH 7.0, 25°C

758432

2.3.1.87

0.47

-

cosubstrate histamine, pH 7.0, 25°C

758432

2.3.3.13

0.1

-

-

636517

2.3.3.13

0.22

-

hydrolysis, absence of MgCl2, pH 7.4, 25°C

672203

2.3.3.16

0.0017

-

methylcitrate synthase exhibiting also citrate synthase activity

488089

2.3.3.16

0.003

-

dimeric enzyme form

488087

2.3.3.16

0.004

-

mutant A361R

488084

2.3.3.16

0.008

-

mutant loop/K313L/A361R

488084

2.3.3.16

0.016

-

wild-type

488084

2.3.3.5

0.0017

-

pH 8.0, 25°C, purified native enzyme

488089

2.3.3.5

0.00188

-

-

705576

2.3.3.5

0.0019

-

pH 8.0, 25°C, purified native enzyme

661700

2.3.3.5

0.00194

-

-

705576

2.3.3.5

0.003

-

-

488087

2.3.3.5

0.0039

-

pH 8.0, temperature not specified in the publication, mutant enzyme G352A

756131

2.3.3.5

0.0047

-

pH 8.0, temperature not specified in the publication, wild-type enzyme

756131

2.3.3.5

0.0053

-

-

488166

2.3.3.5

0.016

-

-

488172

2.3.3.5

0.017

-

-

488171

2.3.3.5

0.037

-

completed mutant strain W620

488172

2.3.3.5

0.045

-

in 50 mM HEPES pH 8.0, at 30°C

720336

2.3.3.5

0.061

-

-

671529

2.3.1.7

8 entries

2.3.1.8

2 entries

2.3.1.81

2 entries

2.3.1.82

3 entries

2.3.1.87

3 entries

2.3.3.13

2 entries

2.3.3.16

5 entries

2.3.3.5

13 entries

2.8.3.1

0.3

-

at pH 7.4 and 30°C

737535

2.8.3.10

1.3

-

pH 8.0, 25°C, isolated transferase

643831

2.8.3.10

3.3

-

pH 8.0, 25°C, integrated into deacetyl citrate lyase

643831

2.8.3.14

0.009

-

pH 8.0, 25°C, cosubstrate (Z)-5-hydroxy-2-pentenoate

643835

2.8.3.14

0.12

-

pH 8.0, 25°C, acetate

643835

2.8.3.10

2 entries

2.8.3.14

2 entries

2.8.3.27

0.0071

-

at pH 7.0 and 25°C

764127

2.8.3.9

0.205

-

pH 7.0, 25°C, cosubstrate acetoacetate

643838

3.1.2.17

1.9

-

pH 6.0, 30°C

643853

3.1.2.20

0.006

-

pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay

690932

3.1.2.20

0.19

-

wild-type protein, pH7.5, 25°C

707486

3.1.2.20

2 entries

3.5.1.51

0.005

0.012

estimated from rates at lower and higher substrate concentration

209188

4.1.3.24

0.2

-

at 30°C

704322

4.1.3.24

1.2

-

pH 7.1, 55°C

651711

4.1.3.24

2 entries

6.2.1.13

0.032

-

at pH 7.3 and 37°C

744820

6.2.1.B11

0.032

-

pH 7.3, 37°C, propionate-forming direction, with propionyl-CoA

744820

6.4.1.2

0.045

-

-

37591

6.4.1.2

0.092

-

wild type subunit AccB, in 100 mM potassium phosphate, pH 7.6, at 30°C

714212

6.4.1.2

0.1

-

at pH 7.5 and 70°C

745205

6.4.1.2

0.144

-

pH 8.0

662786

6.4.1.3

0.032

-

pH 7.2, 30°C

649502

6.4.1.3

0.035

-

-

1869

6.4.1.3

0.056

-

mutant enzyme D422C, in 100 mM potassium phosphate, pH 7.6, at 30°C

714212

6.4.1.3

0.064

-

-

662786

6.4.1.3

0.07

-

pH 7.5, 65°C

651169

6.4.1.3

0.076

-

wild type enzyme, in 100 mM potassium phosphate, pH 7.6, at 30°C

714212

6.4.1.3

0.077

-

mutant enzyme D422V, in 100 mM potassium phosphate, pH 7.6, at 30°C

714212

6.4.1.3

0.1

-

-

1872

6.4.1.3

0.1

-

pH 7.5, 70°C

725234

6.4.1.3

0.1

1

pH 8, 30°C, wild-type

726557

6.4.1.3

0.123

-

mutant enzyme D422N, in 100 mM potassium phosphate, pH 7.6, at 30°C

714212

6.4.1.3

0.159

-

mutant enzyme D422L, in 100 mM potassium phosphate, pH 7.6, at 30°C

714212

6.4.1.3

0.2

-

-

1873

6.4.1.3

0.24

-

pH 8, 30°C, mutant A431C

726557

6.4.1.3

0.262

-

mutant enzyme D422A, in 100 mM potassium phosphate, pH 7.6, at 30°C

714212

6.4.1.3

0.28

-

37°C, pH 8.0, mutant enzyme E168K

662392

6.4.1.3

0.29

-

-

1868

6.4.1.3

0.315

-

mutant enzyme D422I, in 100 mM potassium phosphate, pH 7.6, at 30°C

714212

6.4.1.3

0.32

-

crude extract

1864

6.4.1.3

0.33

-

37°C, pH 8.0, mutant enzyme R165W

662392

6.4.1.3

0.41

-

37°C, pH 8.0, wild-type enzyme

662392

6.4.1.3

0.54

-

37°C, pH 8.0, mutant enzyme R410W

662392

6.4.1.3

0.59

-

37°C, pH 8.0, mutant enzyme A497V

662392

6.4.1.3

1.3

-

pH 8, 30°C, mutant A431I

726557

6.4.1.3

2.6

-

-

1878

6.4.1.2

4 entries

6.4.1.3

25 entries